LOCUS       NZ_CP031749            21104 bp    DNA     circular CON 06-NOV-2024
DEFINITION  Bacillus sp. E25 chromosome.
ACCESSION   NZ_CP031749
VERSION     NZ_CP031749.1
KEYWORDS    RefSeq.
SOURCE      Bacillus sp. E25
  ORGANISM  Bacillus sp. E25
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Bacillus.
REFERENCE   1  (bases 1 to 5915788)
  AUTHORS   Equihua,A., Hernandez-Salmeron,J.E. and Santoyo,G.
  TITLE     Draft genome sequence of an endophytic bacterial strain isolated
            from tomato plants
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5915788)
  AUTHORS   Equihua,A., Hernandez-Salmeron,J.E. and Santoyo,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-AUG-2018) IIQB, Unversidad Michoacana de San Nicolas
            de Hidalgo, Santiago Tapia, Morelia, Michoacan 58000, Mexico
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 13-MAY-2018
            Assembly Method                   :: SPAdes v. 3.10.0
            Assembly Name                     :: Bacillus sp. E25
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: Bacillus sp. E25
            Genome Coverage                   :: 358.587x
            Sequencing Technology             :: PacBio; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003429225.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 01:21:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,042
            CDSs (total)                      :: 5,949
            Genes (coding)                    :: 5,722
            CDSs (with protein)               :: 5,722
            Genes (RNA)                       :: 93
            rRNAs                             :: 10, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 227
            CDSs (without protein)            :: 227
            Pseudo Genes (ambiguous residues) :: 0 of 227
            Pseudo Genes (frameshifted)       :: 94 of 227
            Pseudo Genes (incomplete)         :: 145 of 227
            Pseudo Genes (internal stop)      :: 69 of 227
            Pseudo Genes (multiple problems)  :: 62 of 227
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:28:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 899404
            Orig. end                         :: 920508
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031749.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21104
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="3"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21104
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21104
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11104](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11104
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            267..797
                     /locus_tag="DPQ26_RS04600"
                     /old_locus_tag="DPQ26_04780"
     CDS             267..797
                     /GO_process="GO:0030638 - polyketide metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000764204.1"
                     /locus_tag="DPQ26_RS04600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04780"
                     /product="ester cyclase"
                     /protein_id="WP_208730212.1"
                     /sec_met_domain="PF07366 (E-value: 3.3e-23, bitscore: 80.3,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLEKSLIITIISVFILGVVSTLVYQASTGNNKGNSIKSENVASV
                     SKEVKVKENEKNKKMVVDFYNEVFNKHNIDIIPKYVGEEYKQHNPFVADGRKAFMDFFK
                     EDFVKNPNSSAEIKRVVAEGDTVALHVHSRTNSQDKGVAIVDIFRIKDGKIVEHWDVIQ
                     EIPSEAANDNTMF"
     gene            2007..>3046
                     /locus_tag="DPQ26_RS04605"
                     /old_locus_tag="DPQ26_04785"
     CDS             2007..>3046
                     /NRPS_PKS="Domain: AMP-binding (18-346). E-value: 2.3e-86.
                     Score: 281.9. Matches aSDomain:
                     nrpspksdomains_DPQ26_RS04605_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014895184.1"
                     /locus_tag="DPQ26_RS04605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04785"
                     /product="AMP-binding protein"
                     /protein_id="WP_208730213.1"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-81, bitscore:
                     272.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTNLKLSNRPEHTVQKLFEQQVIQNPDSVALVYKDQQLTYKELN
                     EKVNQLAFYLQKRNIGPESMVGVYIERSLEMIVSILGIIKAGGAYVPLDPAYPTKRLEY
                     ILKDANIQVLLTQNHPTQWIPKEIDCINIKEHEMNISREKNINPTIEVKPDNLAYVIYT
                     SGSTGKPKGVLIEQKSLCNFIISSINLTKMNSDSRNIQFASLSFDASVFEIFTSLVSGG
                     TLYVCSQHDIMPVEPLTQFLQKNKITHALLPPTVLNLLDESVFKDLQVVISAGSACSEQ
                     VAKRWMQNHLFINAYGPTETTVYTVAGIYKGDGAPPIGRSIPNVEVYVLNEAKKLVPIG
                     TVGELY"
     aSDomain        2061..3044
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DPQ26_RS04605_AMP-binding.1"
                     /evalue="2.30E-86"
                     /label="DPQ26_RS04605_AMP-binding.1"
                     /locus_tag="DPQ26_RS04605"
                     /protein_end="346"
                     /protein_start="18"
                     /score="281.9"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="FEQQVIQNPDSVALVYKDQQLTYKELNEKVNQLAFYLQKRNIGPE
                     SMVGVYIERSLEMIVSILGIIKAGGAYVPLDPAYPTKRLEYILKDANIQVLLTQNHPTQ
                     WIPKEIDCINIKEHEMNISREKNINPTIEVKPDNLAYVIYTSGSTGKPKGVLIEQKSLC
                     NFIISSINLTKMNSDSRNIQFASLSFDASVFEIFTSLVSGGTLYVCSQHDIMPVEPLTQ
                     FLQKNKITHALLPPTVLNLLDESVFKDLQVVISAGSACSEQVAKRWMQNHLFINAYGPT
                     ETTVYTVAGIYKGDGAPPIGRSIPNVEVYVLNEAKKLVPIGTVGELY"
     CDS_motif       2247..2288
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DPQ26_RS04605_0001"
                     /evalue="3.30E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="DPQ26_RS04605"
                     /protein_end="94"
                     /protein_start="80"
                     /score="20.1"
                     /tool="antismash"
                     /translation="LGIIKAGGAYVPLD"
     CDS_motif       2478..2534
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DPQ26_RS04605_0002"
                     /evalue="7.20E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="DPQ26_RS04605"
                     /protein_end="176"
                     /protein_start="157"
                     /score="33.8"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVLIE"
     CDS_motif       2892..2921
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DPQ26_RS04605_0003"
                     /evalue="7.20E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="DPQ26_RS04605"
                     /protein_end="305"
                     /protein_start="295"
                     /score="9.1"
                     /tool="antismash"
                     /translation="YGPTETTVYT"
     assembly_gap    3047..3096
                     /estimated_length=unknown
                     /gap_type="within scaffold"
                     /linkage_evidence="align genus"
     gene            <3097..4647
                     /locus_tag="DPQ26_RS04610"
                     /old_locus_tag="DPQ26_04790"
     CDS             <3097..4647
                     /NRPS_PKS="Domain: PCP (25-93). E-value: 3e-16. Score:
                     51.4. Matches aSDomain: nrpspksdomains_DPQ26_RS04610_PCP.1"
                     /NRPS_PKS="Domain: NAD_binding_4 (131-378). E-value:
                     3.9e-49. Score: 159.0. Matches aSDomain:
                     nrpspksdomains_DPQ26_RS04610_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014895184.1"
                     /locus_tag="DPQ26_RS04610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04790"
                     /product="thioester reductase domain-containing protein"
                     /protein_id="WP_261795619.1"
                     /sec_met_domain="PP-binding (E-value: 8.8e-11, bitscore:
                     40.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.8e-47, bitscore:
                     159.0, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="DKDALPAWASIIQTNEGYIAPRNRVEQKMVEIWSEVLGIDSSVIG
                     INDNFFDLGGHSLKIMSTLVKTFSEGWNVTIKDYFELKTINNIAKKIQYGYKVNSHSDT
                     LDIKLTTPPKKLKKTKRHEFSNNSKILLTGATGFLGIHLLEQLLDTTECKIYCLVRGEN
                     KQEANNRLLHMLKFYFKNKFVSYQSLVNQRIFIVQGDLAKQNMGLENELYKELHQQIST
                     VIHAAALTKHFGEYSEFERANVQAVKELLAFVGDTKDLHHISTTGVAGQFALNETETIF
                     KESDFYVKQNYKDNVYVKSKFLAEYEIFKAILTETDATIYRVGNLTNRYIDGQHQYNFT
                     ENAFMSKLKFILQYGIVTDVLLSSEVEFTPVDYCSKIITGFVTSNEIHENSKNCVNHIY
                     NHLTLNLNVLVKLLNSMGYPIKVISETEYQQFILELSKDKKKQEDIQNLMTFEEPKDNC
                     YKPINLDSTETQKTLKLLGIQWPIINSEYIQQIINYMTSVTGSNSVAKLFKQSYTLKN"
     aSDomain        3175..3378
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DPQ26_RS04610_PCP.1"
                     /evalue="3.00E-16"
                     /label="DPQ26_RS04610_PCP.1"
                     /locus_tag="DPQ26_RS04610"
                     /protein_end="93"
                     /protein_start="25"
                     /score="51.4"
                     /tool="antismash"
                     /translation="EQKMVEIWSEVLGIDSSVIGINDNFFDLGGHSLKIMSTLVKTFSE
                     GWNVTIKDYFELKTINNIAKKIQ"
     aSModule        3175..4233
                     /domains="nrpspksdomains_DPQ26_RS04610_PCP.1"
                     /domains="nrpspksdomains_DPQ26_RS04610_NAD_binding_4.1"
                     /incomplete
                     /locus_tags="DPQ26_RS04610"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        3493..4233
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DPQ26_RS04610_NAD_binding_4.1"
                     /evalue="3.90E-49"
                     /label="DPQ26_RS04610_NAD_binding_4.1"
                     /locus_tag="DPQ26_RS04610"
                     /protein_end="378"
                     /protein_start="131"
                     /score="159.0"
                     /tool="antismash"
                     /translation="LTGATGFLGIHLLEQLLDTTECKIYCLVRGENKQEANNRLLHMLK
                     FYFKNKFVSYQSLVNQRIFIVQGDLAKQNMGLENELYKELHQQISTVIHAAALTKHFGE
                     YSEFERANVQAVKELLAFVGDTKDLHHISTTGVAGQFALNETETIFKESDFYVKQNYKD
                     NVYVKSKFLAEYEIFKAILTETDATIYRVGNLTNRYIDGQHQYNFTENAFMSKLKFILQ
                     YGIVTDVLLSSEVEFTPVDYCSKII"
     misc_feature    4939..4955
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.72"
                     /tool="antismash"
     gene            5493..6848
                     /gene="purB"
                     /locus_tag="DPQ26_RS04615"
                     /old_locus_tag="DPQ26_04795"
     CDS             5493..6848
                     /EC_number="4.3.2.2"
                     /GO_function="GO:0004018 - N6-(1,2-dicarboxyethyl)AMP
                     AMP-lyase (fumarate-forming) activity [Evidence IEA]"
                     /GO_process="GO:0009152 - purine ribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="purB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001089379.1"
                     /locus_tag="DPQ26_RS04615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04795"
                     /product="adenylosuccinate lyase"
                     /protein_id="WP_151618676.1"
                     /transl_table=11
                     /translation="MNSTPIDSEIFKDQFGTKQMRTNFSDENLIQLWLNSEVALAKAEA
                     KLGIIPQNAATNIANAADQNKLDFNKIREGMKKTGHPFVAFLHEFESLCDEESRKYIHW
                     GATTQDIIDTGLTLQIKGAHELIYNQTQEILKICLRLSQQYKSTVMPGRTLGQHALPIT
                     FGYKISIWSDELGRHLERLQQGADRYLVGQLGGAVGTLASLGAQGLSVRKEYVKNLNLI
                     EPLVSWHTSRDRFAEFSMILNMIGATTAKVAEEIISLQGTEIREVEEGYHSGKVGSSTM
                     PHKRNPMTCSYIVGLTKIVNRKSTLAIDSMIQKHERDVTFWQSEWSYISEICITLSGAL
                     EQLKNVLTNLIVNEEQMKKNLFLTKGLIVSENVMLELGKIIGRTTAHDLLYELTMRAFE
                     EDKDLKDILLEDNEIKKYFSDEEINSLTNPESYTGLSEKFVDDVYNKWLSYT"
     gene            complement(6884..8785)
                     /locus_tag="DPQ26_RS04620"
                     /old_locus_tag="DPQ26_04800"
     CDS             complement(6884..8785)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NpaA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684559.1"
                     /locus_tag="DPQ26_RS04620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04800"
                     /product="FAD/NAD(P)-binding domain-containing protein"
                     /protein_id="WP_000684560.1"
                     /sec_met_domain="NpaA (E-value: 2.9e-186, bitscore: 618.9,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAIVGLGPRGISVFERIVSNILSELKSESYEISLVDPHPPGGA
                     VWRTDQSPQLLMNTVASQITLFTDDSVQCRGPIVNGPSLLEWANELRDKIDTLDMPTVI
                     TEEIYSLEPNSYPTRALYGYYLKDSFNTILEELPSNIKINLIQDTLINLYPNNEDYTLF
                     LNKSLTPIKAEKVIFTTGHSDQKLTSAEEHFFEFANSNNLNYFPPSNPADVNLDSIEPK
                     TPVIIRGLGLNFFDYMSLLTSGRDGKFEEINDKLNYIPSGKEPLLIAGSRRGLPYHSRG
                     QNQKGSSERHIPLFLKNEVIEQLKHKNNLSFKKEIWPFVKLEVESIYYTTLIRNLYGIE
                     KSCQFLYEFVNCAIEYHKDLLINFGVKSELFFDWHKISCPYGDKKFNSITDFHNWLDTY
                     LHNDINEANLGNKNSPLKAALDVLRDIRNEIRILVDHGGINAESYKEELRNWYTPLNAF
                     LSIGPPVQRIKELRALIRAGILVLVGPEATVATSPINKDFKISSNRVKDSIFHAKNLID
                     ARLPSVNINQSKNILISNMLKAGLASEFKIATNNNYIFESGGLAVTPPPNRLIDKNGKV
                     NPNLYSFGIPTEGVHWVTAAGARPGVNSVTLLESDSIARDVLGCNITINNVYKQTIS"
     misc_feature    complement(8852..8867)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.85"
                     /tool="antismash"
     gene            8899..9708
                     /locus_tag="DPQ26_RS04625"
                     /old_locus_tag="DPQ26_04805"
     CDS             8899..9708
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016097814.1"
                     /locus_tag="DPQ26_RS04625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04805"
                     /product="isocitrate lyase/phosphoenolpyruvate mutase
                     family protein"
                     /protein_id="WP_223838112.1"
                     /sec_met_domain="PEP_mutase (E-value: 2.5e-62, bitscore:
                     208.9, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKLEFKEKIKLFRTLHDQNNPLMLPNAWDASSAKIFERNDFQAI
                     GTTSAGIAATLGYPDGEKIPLELMLNSISNISKNTKLPVSADIEGGYAANIFDLRKILN
                     ELEKFEVVGINIEDGRGTYLREINEQKVILDFIKAYSPHLFINARIDSFWLDIGDLKDR
                     IKDVIVRAEEYKKSGADCIFIPGVKDIETIKVLRENIELPINLLQSENLNSMQNIKTLK
                     IERVSLGSSAFRNILTNLDKISSTFKQGKLLHSNGNLTYQDLNLLMD"
     misc_feature    complement(9751..9765)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.5"
                     /tool="antismash"
     aSDomain        10001..10285
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DPQ26_RS04630_Pantocin_Microcin_RRE.1
                     "
                     /evalue="5.20E-30"
                     /identifier="RREFam017.1"
                     /label="DPQ26_RS04630"
                     /locus_tag="DPQ26_RS04630"
                     /protein_end="95"
                     /protein_start="0"
                     /score="94.5"
                     /tool="antismash"
                     /translation="MKPKFKETIPYFFLNKEIQIGEEEGLAGIIPDPTGSISFLINKLD
                     GQRNIPNIVQEVQKEFPDISSNEIIEAIKVLGNEGYLEDNSIVPELNDYT"
     gene            10001..11104
                     /locus_tag="DPQ26_RS04630"
                     /old_locus_tag="DPQ26_04810"
     CDS             10001..11104
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000802791.1"
                     /locus_tag="DPQ26_RS04630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04810"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_098829685.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 1.1e-27,
                     bitscore: 94.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 4.3e-44, bitscore: 149.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPKFKETIPYFFLNKEIQIGEEEGLAGIIPDPTGSISFLINKLD
                     GQRNIPNIVQEVQKEFPDISSNEIIEAIKVLGNEGYLEDNSIVPELNDYTLERYKANIN
                     YFSLFTKFGEDKYKIQEKILETPIALLGVGGLGTQVLYHLAALGFHNIKALDFDNIELS
                     NFNRQLLYSESDIGNSKVEMAKKRISQFNPNVDLQIINKKIESPQDVIEHIEGTELVIC
                     VADKPTLHIANWVNEGVVKCNLPMVYGGVLNTRGRFFSMIPSKTGCVQCHINYARQLND
                     KQDEQLEAMNNMEFTRNNAAISPNVAIVAGTIVNEALKILTQIAQPISLGKVMEVDFLT
                     LETNTVSSWEKMLDCPLCGQVVKSEVK"
     gene            11111..12343
                     /locus_tag="DPQ26_RS04635"
                     /old_locus_tag="DPQ26_04815"
     CDS             11111..12343
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000937089.1"
                     /locus_tag="DPQ26_RS04635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04815"
                     /product="MFS transporter"
                     /protein_id="WP_000937088.1"
                     /transl_table=11
                     /translation="MLPKVFFNKNYVILFSGMTISKLGMWFFTIAIPLIVYDLTHSPSK
                     MAFVLALELGAQVIFSLIGGALADQMSKKKIMIIGDYASALFVLVVPILFLSGYNSIIV
                     IYIAAFTLSALAAFHHPSFESAVPEILSKEDLIQGNSFFRLSETIITFLGPAVAGIAIA
                     LFGNSNVLLITSVAFFLSGTIFLFLKFRDFAEEEKKRPELVKPIVEGLRYVFGTKIILV
                     GSLVIFGINIGFGAVESLFMYYLKDYLGLSPINIGLIFSLQAIGPILAVYFASKFKHIP
                     RGNVIIYSGIVIGLAQMLLYFSQFSLVILVFCQIFIKGSVTLLAINWFTLRQETVPSKL
                     LGRVISSTRMVAFLALPFSAMIAGFLAESINVLSIFLVAGAFAIVSSIVGVSLGLFDRK
                     RLDKIQNDTAL"
     gene            12371..12850
                     /locus_tag="DPQ26_RS04640"
                     /old_locus_tag="DPQ26_04820"
     CDS             12371..12850
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014471322.1"
                     /locus_tag="DPQ26_RS04640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04820"
                     /product="DinB family protein"
                     /protein_id="WP_001033113.1"
                     /transl_table=11
                     /translation="MNKIELIIMNSNEVRRRSLNLWSSIPSEVLFHRVDSSSMTILEQV
                     RHVLEAEYLYLEILKTRKSLPYSDDEPNPFNTRDFTTIQDEVDFAKPYRKNFLDFIMGL
                     NEEDLENIKIDRSDVGYTRNLGDMLMRMAYHEAVHTGQLLRDMRALGLKRPHLWD"
     misc_feature    complement(13076..13089)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.4"
                     /tool="antismash"
     gene            13131..13364
                     /locus_tag="DPQ26_RS04645"
                     /old_locus_tag="DPQ26_04825"
     CDS             13131..13364
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001005923.1"
                     /locus_tag="DPQ26_RS04645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04825"
                     /product="hypothetical protein"
                     /protein_id="WP_001005923.1"
                     /transl_table=11
                     /translation="MNESVRKSEGELKKYEFTASELEMLFSGFYVAVRQLPENIGPKIY
                     EAIRCKSEDVLLKCLEESIRGSEEKKKEKSGF"
     gene            <13446..13779
                     /locus_tag="DPQ26_RS04650"
                     /old_locus_tag="DPQ26_04830"
                     /pseudo=""
     CDS             <13446..13779
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012259899.1"
                     /locus_tag="DPQ26_RS04650"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="DPQ26_04830"
                     /product="DDE-type integrase/transposase/recombinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="KVKGQWI"
     gene            complement(13819..13968)
                     /locus_tag="DPQ26_RS04655"
     CDS             complement(13819..13968)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016097815.1"
                     /locus_tag="DPQ26_RS04655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000473828.1"
                     /transl_table=11
                     /translation="MFKKLVVGALATGISLIVSAFGTPFNNRMQVLAMLHSKFVEDSVL
                     VQKC"
     gene            complement(<14450..>14566)
                     /locus_tag="DPQ26_RS30605"
                     /pseudo=""
     CDS             complement(<14450..14566)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001214170.1"
                     /locus_tag="DPQ26_RS30605"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLPFTIFFGKHSELRERALQDQLPRSSALKLLINAISLF"
     gene            14706..15035
                     /locus_tag="DPQ26_RS04660"
                     /old_locus_tag="DPQ26_04840"
     CDS             14706..15035
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566267.1"
                     /locus_tag="DPQ26_RS04660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04840"
                     /product="hypothetical protein"
                     /protein_id="WP_000566275.1"
                     /transl_table=11
                     /translation="MIDLLNKWMLESTGNFNIVVGITALLFLGSVIALIIIYKKIGKPD
                     ESTNAIYLKITSRMFTTQILMNAIFISLVGKDIENFRQIFILFEAFVFFIGAIYSFKLY
                     RQEYK"
     misc_feature    complement(15076..15089)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.67"
                     /tool="antismash"
     misc_feature    15077..15090
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.94"
                     /tool="antismash"
     gene            15113..16474
                     /locus_tag="DPQ26_RS04665"
                     /old_locus_tag="DPQ26_04845"
                     /pseudo=""
     CDS             15113..16474
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611143.1"
                     /locus_tag="DPQ26_RS04665"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04845"
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTKFTSEDKMNAVIHYQDGSESIKDIAKSLGANHEVVRMWIKQFE
                     YHGILAFEKGYTTYSAQYKLDVLNYMFENGTSPNETAVIFNISSPGLIRKWRIQLHQKG
                     VDALKSKKKGRQSMTKDNQKSIKKQTQTEESVETLQAELERLRMENAYLKKLNALVQNK
                     EKSPNKIRRK"
     gene            <16501..16602
                     /locus_tag="DPQ26_RS30465"
                     /pseudo=""
     CDS             <16501..16602
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006923582.1"
                     /locus_tag="DPQ26_RS30465"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ornithine cyclodeaminase"
                     /pseudo=""
                     /transl_table=11
                     /translation="VSSGMGLSFEGLPFGGLFCIKSCKARKSRILIF"
     gene            16714..17010
                     /locus_tag="DPQ26_RS04670"
                     /old_locus_tag="DPQ26_04850"
     CDS             16714..17010
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016098426.1"
                     /locus_tag="DPQ26_RS04670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04850"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_086413382.1"
                     /transl_table=11
                     /translation="MAGQIRMSPEELKSKAAQYGQGANQIEDILSQLQNLQNELRGEWE
                     GRAFEGFDQQFNELKPKVQNFAQLLQEINMQLNKTAEAVASHDEELSRNFGLK"
     gene            17173..17448
                     /locus_tag="DPQ26_RS04675"
                     /old_locus_tag="DPQ26_04855"
     CDS             17173..17448
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529644.1"
                     /locus_tag="DPQ26_RS04675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04855"
                     /product="TIGR04197 family type VII secretion effector"
                     /protein_id="WP_086413383.1"
                     /transl_table=11
                     /translation="MGQFQSNLQTATQIATKMESASDRIQSVTTRSITKATRTTLSVNF
                     KAQEANQQILDLTKQFSAAFQQAVDNIHSVSNEFERMDNELHNTFR"
     gene            17489..17851
                     /locus_tag="DPQ26_RS04680"
                     /old_locus_tag="DPQ26_04860"
     CDS             17489..17851
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016121984.1"
                     /locus_tag="DPQ26_RS04680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04860"
                     /product="DUF3958 family protein"
                     /protein_id="WP_000076127.1"
                     /transl_table=11
                     /translation="MSQDIEKQINQVNQKLRSVFEEQDRNQSAIQAQEQAEADFYECRS
                     RNRRLFDRILGTWHGDREMSQFFMNTYQDAQHIERKVTFELENKKETLLKERRDLNDLE
                     NALSYQQQQLTREVNA"
     gene            17848..19488
                     /locus_tag="DPQ26_RS04685"
                     /old_locus_tag="DPQ26_04865"
     CDS             17848..19488
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000056148.1"
                     /locus_tag="DPQ26_RS04685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04865"
                     /product="T7SS effector LXG polymorphic toxin"
                     /protein_id="WP_208730214.1"
                     /transl_table=11
                     /translation="MSLNMYLGEVRSQTQSMNAVCTATIQGMEQAIQSIDAFAVDTVLQ
                     GQTYSSAKAFFVQTFRPLAQGIIYLCEELIRQNDAFPSDFQSQVAQADVIEHEILEQIR
                     EIDRMKTSMEAVNQAMPMPGMDAMVNLFIVMRKKLQEKLDHLYQFNQTSSNNYSTAIQL
                     AASIAAGLAEVQSGKGFSPASGTFSMQGLNMEWTTSIQAITEERARQATNSIEEGEICG
                     KLPEKSTGEKIWDGIVDGTGQAVSDTIDGIKALGDWETWENMGNAALHPIDTLSTMYNA
                     LSDSFINDVINGDAESRAKWGSYALTQVGLGLIGDKGLSKVSKVATTANLTKGMSRVTN
                     SATYRNAINVLNNFNLNIGNRFAYAGIGGSSLKSSFIDAYQTAKDKLSPYQYTKRTTDG
                     DIFVGKLYGEDVILKDVKVDEITYSKRTREEAAKLRRVFQNTVKKEFLYSLATNPEKIL
                     ELKKAGIPDFEIENMKKGKNPSGWQVHHNLPLDDGGTNDFENLTLIQNHPYHKAITNTQ
                     KTLTKDLTHGDSIDIDWPIPKYNIYPKGE"
     gene            19510..19962
                     /locus_tag="DPQ26_RS04690"
                     /old_locus_tag="DPQ26_04870"
     CDS             19510..19962
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002069214.1"
                     /locus_tag="DPQ26_RS04690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04870"
                     /product="YrhA family protein"
                     /protein_id="WP_000265345.1"
                     /transl_table=11
                     /translation="MWKDTLLEVEKTMKSFNLKLNKPAKDTEVQRLRERVKESFNIDLP
                     NEYEEFLRIVNGFEFDGLIIYGVDPSLLETERDETVYGLLENNKIWYENEWQQEYLFLG
                     DSDIAWFCKNISEGTYLELDKPSGTVMETYNDFNTMLEEALKPTLL"
     gene            20002..>20115
                     /locus_tag="DPQ26_RS30010"
                     /old_locus_tag="DPQ26_04875"
                     /pseudo=""
     CDS             20002..>20115
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000529641.1"
                     /locus_tag="DPQ26_RS30010"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04875"
                     /product="TIGR04197 family type VII secretion effector"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRQFQSNLQTATKIATKMGSASDRIQSATSRSITKESK"
     gene            20117..20689
                     /locus_tag="DPQ26_RS04695"
                     /old_locus_tag="DPQ26_04880"
     CDS             20117..20689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000707084.1"
                     /locus_tag="DPQ26_RS04695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DPQ26_04880"
                     /product="imm11 family protein"
                     /protein_id="WP_000707085.1"
                     /transl_table=11
                     /translation="MKIWELKSSFDDYESFQLLNLEEDSKKYFEGKIDSAVKASDSWGE
                     IRIKCVEEGNQSDLPHFWGEVGTPMVSGKAKKFLESILGDNVEFLPLIHDVTGEVYYII
                     NVLNALDAINYEKAILKKLRSGLVIDFKKYAFLPNMVKNQTIFKVYLNEILHIPSVFVS
                     DEFRNTVLESDLKGFEFIEVWDSEANM"
     gene            20726..20851
                     /locus_tag="DPQ26_RS30015"
     CDS             20726..20851
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000382634.1"
                     /locus_tag="DPQ26_RS30015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000382634.1"
                     /transl_table=11
                     /translation="MDVKDLKILRMLNNYEGNEKEIFELIQAEAMVKFICGKIWF"
ORIGIN
        1 gctacaggga agccatttgt agcagatttt tgtcatcttt ataagtttga tgagaacgat
       61 aaggttaaga agtttataca aattgtggac agtgcaactg ttaatgaggt attaagttag
      121 agttaatcgt ttctaatatg ccttgtatag ggggaggata aatgaaattc ctaacattac
      181 ccctgacatt acatttttgg gaaggtttct ccttcttcaa actttttata gaagaaaact
      241 tatttaagta gaagaggtag gtatatatga aattagagaa aagtttaatc ataacaatta
      301 tttctgtatt tattttagga gtagtttcga ctttggtata tcaagcttcc accggtaata
      361 acaaagggaa ctcaattaag agcgaaaatg ttgcttctgt atcaaaagaa gtaaaagtaa
      421 aagaaaatga aaagaataaa aagatggtag ttgatttcta taatgaagtt tttaacaaac
      481 ataatatcga tattatccct aaatatgtag gtgaagagta taagcaacat aatccttttg
      541 ttgctgatgg acgaaaagcc ttcatggatt tctttaagga ggattttgtt aaaaatccta
      601 attcctctgc agagattaaa cgtgtagtag ctgaagggga tacggttgct cttcatgtac
      661 attctcgtac taattctcaa gataagggag ttgctatagt ggatatattt cgtatcaagg
      721 atggaaagat tgtcgaacac tgggatgtaa ttcaagagat tccaagtgaa gcagctaatg
      781 ataatacgat gttttagata gaagatatat ttaataattt tttaattgat agtgctgtat
      841 agaatttaga aatttagata attagttatt aaatttggaa atcatttaaa aatagcatat
      901 taaatgatgg cacaaattaa tacgaaatag ctctttaata aaaaatccta ctcagtaaaa
      961 aatgagtagg attttttatt aaagaatagt gctaattttg tggttcggca ccatctaaat
     1021 ttggaaacca tgaaagtata ggtactctat atccacgtaa agtaaaattg taattttttc
     1081 cttcttttat gtttgcttgc agatccactg aattaaactt catcataaga aggctatcct
     1141 cattagaaat aactttttcg gttccatttt tttgctcaac ctagtacaat ctcaccaatt
     1201 taaaaagacc accattactg gcagtctttc tgtggtatcg agtgtagaga tggttagcta
     1261 cttatctgtt taggcataat ctaggatctt tagaattctt aatttgaaca atctattttt
     1321 atattattta aatagtaatc ttttatagac ccactcattt tagttaacct ttgttcaaat
     1381 ataaatgaag tcgcaattgt aactagatgc acaattaatc aaaatagaaa aaagtaccta
     1441 taagagtagg tacttttttc tttgttatat ataaattata cattaattta tatttggaac
     1501 actttaaaaa gaaaagatga tgatggattt attaatagat gcgtataact atatgtatat
     1561 atttaatgca tatattattt ttagataaat atatatatct ttcagtaaga atgcaatatt
     1621 cttcgctatt tacttatatt tataatttaa ctaattcatt ataatatcaa tgttgattta
     1681 aagttttttg tacaaaatga acagatggga tttttttagg gatgcaaata caatgaatca
     1741 ttctgttttc ttaattgact aaatttttaa aatttaaacc ttcaaatgtt aatacttgtt
     1801 atataattga cttattaagg cattgcccct aaaagttaat atgcctaatg agattgttta
     1861 cgttttcctt atggggtagc accaacattt catagattct gtacgctaag gctataatct
     1921 ttataattcc tgagcgtatg aaattcgcgc tttgttgttg ggaccgctat gagtactgtt
     1981 aaatataata ttcaaggagt gatataatga atactaatct taaattatca aacagaccag
     2041 aacacactgt tcaaaaatta tttgaacagc aagtaattca gaatccagat tctgttgcgt
     2101 tggtatataa agatcaacag ttaacttata aggaattaaa tgaaaaagta aatcaattag
     2161 ctttttatct acaaaaacga aacataggcc ctgaaagtat ggtaggggtt tatatagaac
     2221 gttctttaga gatgattgta agtatattag gaataataaa agctggtggc gcatatgtcc
     2281 cactagatcc cgcatatcca acaaagaggc ttgaatatat cttgaaagat gccaacatac
     2341 aagtattgct aacccaaaac catccaacac agtggatacc taaagaaata gactgtatta
     2401 atataaaaga acatgaaatg aatatttcga gagaaaaaaa tataaatcct acaattgaag
     2461 ttaaaccaga taatttggca tatgtaatct atacatctgg atctacagga aaacccaaag
     2521 gggtattaat tgaacaaaaa agcttatgta actttattat ttctagtatt aatttaacaa
     2581 aaatgaattc agacagtaga aatattcaat ttgcctcatt atcatttgat gcttcagtat
     2641 ttgagatatt tactagccta gtttcaggtg gaactttata tgtatgtagt caacacgata
     2701 ttatgccagt tgaaccactt actcagttct tgcaaaaaaa taaaattaca catgcacttt
     2761 taccccctac ggtacttaat ttgttagatg aatctgtatt taaagattta caggttgtta
     2821 tttctgcggg atcagcctgt agtgaacaag tggcaaaacg atggatgcaa aatcaccttt
     2881 ttattaatgc gtatggtcca acagaaacta cagtttatac cgttgcggga atatacaaag
     2941 gagatggagc acctcctatt ggtcggtcca ttcccaatgt agaggtatat gtattaaatg
     3001 aagctaaaaa acttgtccct attgggacag taggtgaact ttatatnnnn nnnnnnnnnn
     3061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngata aagatgcttt acctgcatgg
     3121 gcctctatta tacaaacgaa cgagggatat atagcacctc ggaatagagt agagcaaaaa
     3181 atggtagaaa tttggtcaga ggtattaggg attgactcct ctgtcattgg gataaatgat
     3241 aatttttttg atctaggtgg gcactcttta aaaattatga gtactttagt aaaaacattt
     3301 tctgaaggtt ggaatgtaac tattaaagat tactttgaat taaaaacaat taataatata
     3361 gctaaaaaaa ttcaatatgg atataaagta aattcacatt cagatacatt agatattaaa
     3421 ttgacaactc ctccaaagaa gctaaagaaa acaaaaagac acgaatttag taataatagc
     3481 aaaatacttt taacaggtgc tacaggattc ttaggtattc acctactaga acaactattg
     3541 gatactacag aatgtaagat atattgttta gttcgtgggg aaaataaaca agaggcaaat
     3601 aatcgtttat tacacatgtt aaaattttat tttaaaaata aatttgtaag ctatcaatct
     3661 ttagtaaatc aacgtatctt tattgtacaa ggtgatttag ctaaacaaaa tatgggatta
     3721 gaaaacgaat tatataagga gcttcatcaa caaatatcaa ctgttattca tgctgcagct
     3781 ttaacaaaac attttggcga gtatagtgaa tttgaaagag caaatgtcca ggcggtaaaa
     3841 gaacttcttg catttgttgg tgatactaag gatttacatc atatatctac aactggtgta
     3901 gccggacaat ttgcattaaa tgaaacggaa acaatattta aagaaagcga tttttatgta
     3961 aaacaaaatt acaaagataa tgtatatgtg aaaagtaaat ttttggcgga atatgaaata
     4021 ttcaaggcaa tattaacgga aacagatgct actatttata gagtaggaaa tcttacaaat
     4081 agatatatcg atggacaaca tcaatataac ttcaccgaaa atgcatttat gagcaaatta
     4141 aaatttatat tacaatatgg tatcgtgaca gatgtattat tatcaagtga agttgagttt
     4201 acacctgtag attattgcag caaaattatc acagggtttg taacttcaaa tgaaatacat
     4261 gaaaatagca aaaattgcgt aaatcatata tacaatcatc ttacgttaaa tttaaatgta
     4321 cttgtaaaat tactaaattc aatgggatat ccaattaaag taatttctga aacagagtat
     4381 caacaattta ttttagaact ttctaaagat aaaaagaaac aggaagatat tcaaaacctc
     4441 atgacatttg aagaaccaaa agataattgt tataaaccaa taaatcttga ttcgactgaa
     4501 actcaaaaaa cactaaaatt attaggtatt caatggccta ttattaatag tgaatatata
     4561 caacaaatta ttaattatat gacgagtgtt actggtagta attctgttgc aaagcttttt
     4621 aaacaaagtt acactttaaa aaactgaaca gactcatgag aaatgagaaa ttttaaagga
     4681 acacagttaa aaaaatacgc aaaatttttt agacaaaatc actgaaatag gacaagcttt
     4741 taggcggaat tatatgcata attattgtga ttctatcctt tataaggaaa taatttttaa
     4801 tcagcaaaca catgtaacct tttgaatatt gggtaaaaga caccctagta gagtttttca
     4861 tatcgtatga gacattgctg tcgaaaaatt gcaaacagat gggaaaatac aacaagctat
     4921 tatccaacaa agaaagaaat acccccatag aatacgttag agcgttagat acattagaag
     4981 aatttaatga attgaattta gactatgtag agacgagtat gaaggaataa taacaatata
     5041 acaagtactt tttcagcttt ctacgttata taaggtaagg ggaaaactgt catcgagatt
     5101 acaattttaa gtggattatc tttttcttta tggggaataa catcgttaaa cacgttatat
     5161 gaacaagcta cagtaacaaa aggagatgtg tagccattgg aacagggagt agcggatatt
     5221 taagttgata attgggaaca ggaaatgaat aaatgatagg tgaagtattc ttgggaaccc
     5281 atggttctta caacagataa aagatccctt cgtttgttac gaaaagaatc ttttatctgt
     5341 tgtgtttttt tgttcttttg ttcccgtatt ccttttcatt ttaggtttca aaaatatata
     5401 aaatcaattt taagacaaat tacttacatt aatatgctaa tatcaatagt agatatttta
     5461 tcttaaatta atgaaaaaga aaggtgatac taatgaattc gacaccaatt gattctgaaa
     5521 tctttaagga ccagtttggt acaaaacaaa tgagaacaaa tttttcagac gagaatttaa
     5581 tacaattgtg gcttaattca gaagttgcct tagcaaaagc tgaagctaaa ttaggtatta
     5641 tacctcaaaa tgcagcgact aatattgcaa atgcagctga ccaaaataaa cttgatttta
     5701 ataagattag agaaggaatg aaaaaaactg gacacccctt tgtagcattc ctacatgagt
     5761 tcgagagttt atgtgatgaa gaatcacgta agtacattca ttggggagca acaacacaag
     5821 atataattga cacgggactt accctgcaaa ttaaaggtgc tcatgaactt atttataatc
     5881 aaactcaaga aatattaaag atatgtttga gattaagcca gcaatataag tcaacagtaa
     5941 tgccaggcag aacgttaggt cagcatgcct taccgattac ttttggatat aagatatcta
     6001 tatggtcaga tgaacttggt cgtcacttag aaaggttaca acaaggtgca gaccgatatt
     6061 tagtggggca actgggaggt gcagttggta ctttagcttc attaggagcg caagggttat
     6121 ctgttagaaa agagtatgta aaaaatttaa acctaattga acccttagta tcttggcaca
     6181 cgtctagaga ccgatttgca gaatttagca tgattttaaa tatgattgga gcaactacag
     6241 ctaaagttgc agaagaaata ataagccttc aaggaacaga gattagagaa gtagaagagg
     6301 ggtaccattc tggtaaagta ggaagtagca ctatgccgca taaaagaaat cctatgactt
     6361 gctcttatat tgtgggatta actaaaatag tcaatagaaa atcaacttta gctattgaca
     6421 gtatgattca gaaacacgaa agagatgtta cattttggca atctgaatgg tcttatattt
     6481 cggaaatttg cataacttta agcggcgcat tagaacaact taaaaatgtc ttaacaaact
     6541 taatagtaaa tgaagaacaa atgaaaaaga atctttttct taccaaaggt ttaatagtat
     6601 ctgagaacgt aatgttagaa ttggggaaga taattggtag aactactgcc catgatttat
     6661 tgtacgaatt aacaatgaga gcttttgaag aagacaaaga tttaaaagat attttattag
     6721 aagacaatga aattaagaag tattttagcg atgaagagat aaattccctt actaatccag
     6781 aatcatacac agggttgagt gaaaagtttg ttgatgatgt ttataacaag tggttgagtt
     6841 atacataaaa ccaatttaag accattagct gaggaataat tcctcagcta atggtctgct
     6901 tatacacatt attaattgta atattgcagc ctagaacatc tcttgcaatt gaatcggatt
     6961 caaggagtgt tacagaatta acccctggtc gcgctcccgc agcagttacc caatgaacgc
     7021 cttctgttgg aattccaaag gagtataaat taggattaac tttaccgttt ttatctatta
     7081 atctatttgg ggggggagtc actgctaaac ctccactttc aaaaatataa ttattgttcg
     7141 ttgcaatctt aaattctgag gctagacctg cttttaacat atttgagatt aaaatatttt
     7201 tactttgatt tatattaact gagggtagtc tagcatcaat taggttcttt gcatgaaata
     7261 tcgaatcctt aacacggtta gagctaattt taaaatcttt atttataggt gaagtagcta
     7321 cagttgcttc aggtccaact aaaactaaaa ttccggctct tattaatgcc ctcaattctt
     7381 tgattctttg aacaggaggg ccaattgaaa gaaatgcgtt taaaggtgta taccaattgc
     7441 gtaactcttc tttataagat tcagcattta ttcctccatg atcaacaagt attcttattt
     7501 cgtttcggat atcccttaaa acatctaatg cggcttttag tggactgttt ttattaccca
     7561 ggtttgcttc gttaatatca ttatgtaagt aagtatctaa ccaattatga aagtctgtta
     7621 ttgaattaaa ttttttatca ccataaggac aactaatttt gtgccaatca aaaaatagtt
     7681 ctgattttac tccaaagttg attaaaagat ccttatggta ttctatggca caattaacaa
     7741 actcgtaaag gaactgacaa gatttttcta ttccatagag attgcgaatt aaagttgtat
     7801 aatagatact ttcaacttcc aattttacga aaggccatat ctctttttta aagcttaggt
     7861 tatttttatg ttttaactgc tcgataactt cattttttag aaatagtggg atatgtcttt
     7921 ctgaagaacc tttttgattt tgtcccctag agtgataagg taagcctcgc ctagaacctg
     7981 caattaataa aggttcttta ccagagggaa tgtaatttaa tttgtcatta atttcttcaa
     8041 actttccatc tctcccactt gttaaaagtg acatgtaatc aaaaaaatta aggcctaatc
     8101 cccttattat tacgggagtt ttaggttcta ttgaatctaa attaacatct gctggattgg
     8161 atggtgggaa gtaatttagg ttgttactat tagcaaactc aaagaaatgt tcttcagctg
     8221 aagttaattt ctgatctgag tgcccagttg taaagataac cttttcagct ttaattggtg
     8281 ttaaagactt attaagaaat aaagtataat cttcattgtt cggatagaga ttaattaatg
     8341 tgtcttgaat taagttaatc ttaatatttg agggtaattc ttcaagaata gtattaaatg
     8401 aatctttaag ataatagccg tatagagctc ttgtagggta agagttaggt tctaaggaat
     8461 aaatttcttc tgtaataacg gtgggcatat ccaaagtgtc aattttatcc cttaattcat
     8521 ttgcccattc taatagacta ggcccattaa cgataggacc ccgacactgg acgctatcat
     8581 cagtaaataa agttatttgc gaagccactg tattcattaa aagttgaggt gactggtctg
     8641 ttctccatac agctccacct ggaggatgtg gatcaaccaa ggaaatttca taagattctg
     8701 attttaattc agataaaata ttagagacta ttctttcaaa tactgatata cctcttggtc
     8761 ctaaacctac tatcgcaatt ttcatatact cacacctatc ctttctgcaa gatctaattt
     8821 aatccgttat gtaaaacaac ataactagta ggtgcaaaaa aagtcaagtg taaaactaaa
     8881 aaaataattt actaaagggt gtttaaattg gaatttaaag agaaaattaa gttatttcga
     8941 acgttacatg atcaaaacaa tccattaatg cttccaaatg catgggatgc atcaagtgct
     9001 aagatttttg agagaaacga ttttcaagcg attgggacta ctagtgctgg tatcgcagca
     9061 accttaggtt atccagatgg cgagaagatt cctttagagt taatgttaaa ttccattagt
     9121 aatatctcga aaaataccaa acttcctgtt tcagctgata ttgaaggagg atatgccgct
     9181 aatatttttg atttacgaaa aatattaaat gagttagaaa aatttgaagt ggtaggtata
     9241 aatatagagg atgggagagg tacgtattta agagaaatta atgagcaaaa ggtcatttta
     9301 gactttatta aagcttattc gcctcatctt ttcataaatg caagaattga tagtttttgg
     9361 ctagatattg gcgatttaaa agatcgtatt aaggatgtaa tcgttcgtgc agaagaatat
     9421 aaaaaatccg gagcagattg tatttttatt cctggagtta aggatattga gacaataaaa
     9481 gtacttagag aaaatataga gttacctata aatttgcttc aaagtgaaaa cttaaattcc
     9541 atgcaaaaca taaagacact aaaaattgag agagtgagtc ttggatcttc agcttttagg
     9601 aatattctaa caaaccttga taagataagc agcaccttta aacaggggaa attattacat
     9661 tcaaatggaa acttaaccta tcaagactta aacttgctta tggattgatt ttttacaggt
     9721 gaataaacta ctaaaaatag ttatttctat aattttcaaa aaaaagtttc tcaacctgaa
     9781 actatcagac tattatgtaa tttctctttt ttgtgtgtta tgctagattt atcaaatgta
     9841 ggaggtgatt acatatgatc gttaaagtaa aaaaagcttc taaaaaagta gttgctgcta
     9901 atgcacttac taatgtacca ggttaagtca ttaagaagaa ccggatttcc ggttcttctt
     9961 aattttttaa ttaatcaatt aattaaggag atgttataaa atgaaaccaa aatttaaaga
    10021 aactatccct tattttttcc taaataaaga aattcaaatt ggtgaagaag aaggtttagc
    10081 aggtataatt ccagacccta ctggtagcat ctcatttcta ataaataaat tagatggcca
    10141 gagaaacatt ccaaacatcg ttcaagaagt acaaaaagaa tttcctgata ttagttcaaa
    10201 tgaaattatt gaggctataa aagttttagg aaatgaaggt tatttagaag ataattcaat
    10261 tgtaccagaa ctcaatgatt acaccttaga aagatataaa gcgaatataa attatttttc
    10321 actattcacg aaattcggag aagataaata taaaattcaa gaaaagattt tagaaacgcc
    10381 tattgcactt cttggtgtag gaggacttgg aacacaagta ctgtatcatt tggcagcatt
    10441 aggatttcat aatataaaag ctctggactt tgataatatt gaattaagta attttaatag
    10501 acagttgctt tattcggaat cagatatagg gaatagtaag gttgaaatgg ctaaaaagcg
    10561 aatatcccaa ttcaacccta atgtggatct tcaaattata aataagaaaa tagagtcacc
    10621 tcaagatgtg attgaacata ttgaaggaac tgagcttgtg atatgtgttg cagataagcc
    10681 aacattacat attgcaaact gggtaaacga aggtgtggtt aaatgtaatc tgccaatggt
    10741 ttatggtgga gtattaaata ctcgtggtag attcttttct atgattcctt ctaagacagg
    10801 ttgtgtacaa tgtcacatta attatgcaag acaattaaac gataaacaag acgagcaatt
    10861 agaagctatg aataacatgg agtttactag aaacaatgct gctataagtc caaacgtagc
    10921 tattgtagct ggaacaattg ttaatgaagc attaaaaatt ttaacgcaga ttgcacaacc
    10981 tatttcttta gggaaagtta tggaagtgga ctttttaacc ctagaaacta atactgtttc
    11041 ttcgtgggaa aaaatgttag attgtcctct ctgtggtcaa gtagttaaaa gtgaagtgaa
    11101 gtgatttgat atgctaccta aagttttttt taataagaat tatgtaatac ttttttctgg
    11161 gatgacaata agtaaattag gaatgtggtt cttcactata gcaattccat taattgttta
    11221 tgatttaacc cattctccaa gtaaaatggc cttcgtacta gcattagagc ttggagccca
    11281 agttattttt agtttaatag gtggggcatt agcagaccaa atgtctaaaa agaagataat
    11341 gataatagga gactatgctt cagcgctttt tgtactcgta gttcctatac tttttttaag
    11401 tggttataac agcataatag ttatatatat tgccgctttt accttatctg ctttagcagc
    11461 ttttcatcat cctagttttg aatctgcagt tcctgaaatc ttatctaaag aggatcttat
    11521 tcaaggtaac tcattcttta gactaagcga aacgattatc acattcttgg gacccgccgt
    11581 agcggggatt gcaatagcgc tttttgggaa ttcgaatgtt ttattaataa caagtgtggc
    11641 cttcttttta tcaggaacaa tatttttatt tttaaaattt agagattttg ctgaagaaga
    11701 gaagaaacgc cctgaattag taaaacctat tgttgaagga ctaagatatg tctttggaac
    11761 gaaaattatc ttagttggtt ctctagttat ttttggtatt aatataggat ttggagctgt
    11821 agaatctctt tttatgtatt acttgaaaga ttatctaggc ttgagtccta taaatattgg
    11881 attaattttt tcattacagg caattggacc aattttggct gtttattttg caagtaaatt
    11941 taaacatatt ccaagaggaa atgttattat ttattcaggg attgttatag gacttgccca
    12001 gatgctcctg tacttctctc aattcagctt agtaatttta gtattctgtc aaatttttat
    12061 taaaggatca gttactttat tagctattaa ttggtttaca ttgcgacaag agactgtacc
    12121 tagcaagttg ctcggaagag ttatcagttc tactagaatg gtagcatttt tagctttacc
    12181 ttttagtgct atgatagctg gctttttggc tgagtcaata aatgttttgt caatcttctt
    12241 agttgcaggt gctttcgcga tagtatcatc aatcgtaggt gtaagtcttg gtttatttga
    12301 tagaaaaaga ttagataaga ttcaaaatga tacagcattg taattagtta agtgtaaagg
    12361 gagttatttt atgaacaaaa ttgaactaat aattatgaat tctaatgaag tacgccggag
    12421 aagtttaaat ttatggagtt ctattcccag tgaggtttta tttcataggg ttgattcatc
    12481 ttcaatgact atattagaac aagtacggca tgttttagaa gctgaatatt tatatcttga
    12541 aattttaaag actagaaaaa gtttgcccta tagcgatgat gaaccaaatc ctttcaatac
    12601 acgcgatttt acaaccattc aagatgaggt tgattttgca aaaccttatc gaaaaaattt
    12661 cttagatttt ataatgggat taaatgagga agatcttgaa aatataaaaa tagatcgctc
    12721 agatgtagga tatactagaa accttggaga tatgttaatg agaatggcgt atcatgaagc
    12781 cgtacataca gggcaattat taagagatat gagggcttta ggtttaaaaa gacctcatct
    12841 atgggattaa attaaaaatg gttatccgtt agcattctaa ataaatgttt ctatttctga
    12901 cgagttatac atgttaaaat atataacatg agtatgtagg gggaagagtt atgagcactg
    12961 aagagttttt aacagatatt catgagcaca ctccgagtta tagacagata aaaatggaag
    13021 cgttgagaag atttcctaat gaacgtttgc aagttattga atatatataa gaaaatgcaa
    13081 gtttatacga ttatttaata tgtttgttag atataacaca gaatgctctg gtgaatgaat
    13141 ctgtacgcaa atcggaaggc gagttaaaga agtatgagtt tacagcaagt gaattagaaa
    13201 tgttgtttag tggattctat gttgcagtta ggcaattgcc tgagaacatt ggacctaaaa
    13261 tttatgaagc tattcgatgc aaaagtgaag acgtattatt gaagtgttta gaagaatcaa
    13321 taagagggtc tgaagaaaag aaaaaagaaa aaagcggatt ttaacattga aatttatcgt
    13381 acaaagaatt gacacttaaa tccctcacaa acgttacaga aagatataag acctaagttg
    13441 aaagaaaagt aaaaggtcaa tggatatagt tatattgtgc agttgattca gagggtaata
    13501 caattgattt ttatctaagt aaatcaagag ataaaccagc agtcaagcgc tttttcaaga
    13561 aagccttggc tttttcgcat gtttctaaac ctcgtgtgat aacagtagat aagaaccctg
    13621 cctatcctgt agagattcaa gtcatttaaa acagcaatct ctatattgag tggtgtcgaa
    13681 tctatgcata tgataaaaaa cgggcaactt gttttaccgg acaagtctgt ccaaaatcag
    13741 aaagaattta ttcctaaatg gtttggctta gcttcataag atagaaatga agagaaaatt
    13801 gctattctat gtttccaact aacatttttg caccagaacc gaatcttcaa cgaatttact
    13861 atgtaacatg gctaacacct gcatcctatt attaaacggt gttccaaatg cactaacaat
    13921 taagctaata ccagttgcta atgctccaac tactaatttc ttgaacataa taaatccccc
    13981 ttaatatttt ttataacttg caccttaaat atatcacttt tcttattttg taaatgtttt
    14041 gaatttgtag aaatgtttat ttgaatctta ttaatattgg taattcattt tattaagtgg
    14101 aaaatagagg gatttttata ggtatgtaaa aatacataat aaatgaaccg aatattatga
    14161 tatactctca aagagctgat acaaaacttc tttagattgg aaaactaaag tcttatctac
    14221 ccaattgtgg gggcgcctta tggcgtcttt tttttataag aaacctccaa gcattcatac
    14281 acttgagggt ttatcaattg aaaggtaggg ctgtttggag ttccttaaat taagaacaaa
    14341 gcgggattat tcctaaacca attaatagag ctgcagcaaa cgctggaatt ggcacaggga
    14401 tctcgatact ttctacaact aagaagtatt gtgtccactt actactttaa aacaaactaa
    14461 ttgcattaat taagagtttt agtgcactac tccttggaag ttgatcttgt agcgctcttt
    14521 ctcgtaattc actatgtttt ccaaagaaaa tagtgaaagg caaggcgatg aatacattta
    14581 caaaatgaca aaactgtaag aatacacgaa tgtttgtaag aaagttcgat gttttccttt
    14641 ttcttttttt attatagtga aaaagaagga cgaaatattc tcttatgtag gaaaggaaga
    14701 taataatgat tgatctatta aataaatgga tgttagaaag tacaggcaat ttcaatatcg
    14761 ttgtaggaat tacagcactt ctatttttgg gttcagtaat tgcacttatt attatttaca
    14821 aaaaaattgg taaaccagat gaaagcacaa atgctattta tttaaaaatt acttctcgta
    14881 tgtttactac tcaaattcta atgaatgcta tatttatttc tttagttggt aaagatattg
    14941 agaatttccg tcaaatcttt atattatttg aagcttttgt attttttatt ggagctattt
    15001 attcgtttaa attatataga caggaatata aataatttac ttgcaagaaa caataaaaaa
    15061 actgcacccc aattgttaga cacagtctaa caattggagg tgtagttttt ttatgactaa
    15121 atttacttca gaagacaaaa tgaatgcagt aatacattat caagatggaa gtgagagtat
    15181 aaaagatatt gcgaaatcat tgggagcgaa tcacgaagtg gttcgcatgt ggataaaaca
    15241 atttgaatat catggaatcc tggcctttga aaaaggctat acaacgtatt ctgcacagta
    15301 taaactagac gtactaaatt atatgttcga aaatgggacg tctccaaacg aaacggcagt
    15361 catttttaat atttcttcac ctggacttat tagaaaatgg cgtattcagc tacatcaaaa
    15421 aggagtagac gcccttaaat cgaagaaaaa ggggcgtcaa tctatgacta aggacaatca
    15481 aaaatcaatt aagaaacaaa cacaaacaga agagtcagta gaaacattac aagctgaatt
    15541 ggagcgtttg cgtatggaga atgcttattt aaaaaagttg aatgccttag ttcaaaacaa
    15601 ggaaaaatca ccaaacaaga taaggcgcaa gtaatctatg aactaaggaa agcatttccg
    15661 gtgcaggcac ttttaaaatt agcagaactc ccacgaagta catattatta ctggatacag
    15721 aattctaatc gaccagataa agataaagag ctaaagatcc ttaattcaaa acatttacga
    15781 tgaacaccaa ggtcgttatg gatatcgccg tattcgcgat gagttaatga accaaggaca
    15841 caaaatcaac cataaaaaag ttcaacgaat tatgaaagag ttaggtttaa agagtctagt
    15901 tcgtatgaaa aaatatcgct cgtataaagg acaagtaggt aagattgcgc caaatatttt
    15961 agaacgtaat tttaaagctg aaaagccgaa cgaaaaatgg gttacagaca taacagaatt
    16021 taaattatgt ggcgagaagc tctacttatc accgatgtta gatctattta atggagagat
    16081 aatcgcttat acaattgatt caagaccaac ctattcactt gtatcgaaga tgttggagaa
    16141 gtcttttcaa caattgacag aagaagacga actccttatt cactctgatc aaggctggca
    16201 ttatcaaatg aagaagtatc gtcacgccct aaaggaacgc aagattacgc aaagtatatc
    16261 tcgtaaaggg aactgttacg ataatgcggt tattgaaagt ttctttggta ttatgaaaac
    16321 tgaatttctt tatctaaaag attttgaaag catagaacac tttaaacaag aatttgaaaa
    16381 atatatcgat tattataatc acaaaagaat taaggcaaaa ctaaaaggca tgagtccggt
    16441 acaatatcga actcatgccc taaaggctgc ctaatgaaac gacctgtcta actttatggg
    16501 gtcagttcag ggatgggatt gagttttgag ggactgcctt ttggtggtct tttttgcata
    16561 aaatcttgta aagcaagaaa aagtagaata ttaatattct aatattcaat agaaagataa
    16621 agtgtttaaa agttcaaaat aatacattat aatctattta gtaaaattaa ccaaaatata
    16681 ttttgcttat tatgtattaa aggggaaatg aaaatggctg gacaaattcg tatgtcacca
    16741 gaggagctta aatcaaaagc ggctcaatat ggacaaggtg caaatcaaat tgaggacatt
    16801 ttaagtcaac tacaaaactt gcaaaatgaa ttaagaggag aatgggaagg tcgtgctttc
    16861 gaaggttttg atcaacagtt caatgaatta aagccaaaag tacaaaactt tgcacagcta
    16921 ttacaagaaa ttaatatgca gctgaataaa actgcagaag ctgttgcttc tcatgatgaa
    16981 gaattatcac gtaatttcgg tttgaaataa aaattgtcat actctatata acaagcattt
    17041 caaatgagcc atacagctta tattgtatgg ctcatttgat tgcatgccta gagcgagtga
    17101 tattgatagg gatatatatt ttatgagatt tctttgatgc gtttggaaaa cttatagaaa
    17161 gggtttgaaa gaatgggaca atttcaaagt aatttacaaa cagcaacgca aattgctacg
    17221 aaaatggaat cagcctctga taggattcaa agtgtaacaa ctcgttctat aacaaaggcg
    17281 acgcgtacaa cattatctgt taacttcaaa gcacaagaag cgaatcaaca aatattagac
    17341 ttgacgaaac aattttccgc tgcctttcaa caagcggttg ataatattca ttcggtatct
    17401 aatgaatttg agagaatgga taacgaactt cacaatactt ttcgctaatg tgacaaccta
    17461 cgtaaagtaa aatagtagga ggaaaaagat gagtcaagat attgaaaaac aaattaatca
    17521 agtaaatcaa aagttacgaa gtgtatttga agaacaagac cgaaatcaat ctgcgattca
    17581 agctcaagaa caagcggaag cagattttta tgaatgtaga agtcgaaatc gtcgtttgtt
    17641 tgatcgaatt ttaggaactt ggcatggtga tagagaaatg tcccagtttt ttatgaatac
    17701 gtatcaagat gcacaacata ttgaacgaaa agtcacattt gaattggaaa acaaaaaaga
    17761 aacgttgctt aaagaaagac gagaccttaa tgatttagaa aacgcccttt cctatcaaca
    17821 acaacaatta acaagggagg tcaatgcatg agtttaaata tgtatttggg agaggtacga
    17881 agccaaactc aaagcatgaa tgctgtatgt accgctacta ttcaaggtat ggaacaagcc
    17941 attcagtcga ttgacgcttt tgcagttgat actgttttac aagggcaaac atatagtagt
    18001 gcaaaagcat tttttgtaca aacctttcga cctttggcac aaggaatcat ttatttgtgt
    18061 gaagaattaa tccgtcaaaa tgatgctttt ccaagtgact ttcaatcaca ggtagctcag
    18121 gcagatgtaa ttgaacacga gatattagaa caaattcggg aaattgaccg aatgaaaaca
    18181 agtatggaag ctgtcaatca agctatgcca atgccgggta tggatgccat ggtaaatctt
    18241 tttattgtta tgaggaaaaa actgcaagaa aagctggatc atttgtatca attcaatcag
    18301 acctctagta ataattatag tacagcaatt caattagcag cgagtattgc tgcaggtctt
    18361 gcggaagtcc aaagtgggaa agggtttagt cctgcaagtg gtacatttag tatgcaaggg
    18421 ttgaatatgg aatggacaac ttcaattcaa gcgattacag aagagagggc acgacaagct
    18481 accaattcaa ttgaagaagg tgaaatatgt ggtaagctac ctgaaaaatc tactggtgaa
    18541 aaaatttggg acggtattgt agatggcacg ggacaagcag ttagcgatac aatagacgga
    18601 ataaaagctt taggggattg ggaaacgtgg gaaaacatgg ggaacgctgc tttgcaccct
    18661 attgataccc ttagtaccat gtataatgca ttgtcagatt catttattaa tgatgtaata
    18721 aatggagatg cagaaagtcg ggcaaagtgg ggaagttatg ctttaacaca agttggatta
    18781 ggacttattg gtgataaagg attaagtaaa gtatcgaagg tagcaactac tgcaaatcta
    18841 acaaaaggta tgtccagagt aactaattct gctacatata gaaatgcaat aaacgtatta
    18901 aataatttta atttaaacat tggaaaccgt tttgcttatg ctggtattgg gggaagttct
    18961 ttaaaatcta gctttattga tgcttatcaa acagctaagg ataagctatc accttatcaa
    19021 tatactaaaa ggactacgga tggtgacatt tttgttggta aattatatgg agaagatgta
    19081 attcttaaag atgttaaagt tgatgaaatt acttactcta agagaactcg agaagaagct
    19141 gcaaaactta gaagggtttt tcaaaatact gtaaaaaagg aattccttta cagtttggca
    19201 actaatcctg agaagattct tgaacttaag aaagcgggta taccagattt tgaaatagaa
    19261 aatatgaaaa aaggaaaaaa tccatcaggg tggcaagtac atcataacct ccccttagat
    19321 gatgggggga caaatgactt tgaaaattta actttaatac aaaatcatcc atatcataag
    19381 gctattacta atacacaaaa aacactaact aaagacttga ctcatggaga tagtattgat
    19441 atagattggc ctataccaaa atataatatt tatcctaaag gggaataaat tgagaaagaa
    19501 ggtttttata tgtggaaaga tacgctttta gaagttgaaa aaacaatgaa aagttttaac
    19561 ctcaaactga ataaaccagc aaaagatact gaagttcaaa gattaagaga acgtgttaaa
    19621 gaaagcttta atattgattt gcctaatgag tatgaggaat ttcttagaat tgtaaatggc
    19681 ttcgaatttg atggtctgat aatttatgga gttgaccctt ctttactaga aacagaaaga
    19741 gatgaaacag tttatggact tttagaaaat aataagattt ggtatgagaa tgagtggcaa
    19801 caagagtacc ttttccttgg agattcagat atagcatggt tttgtaaaaa catatctgaa
    19861 ggtacttact tagaacttga taaaccatct ggtacagtga tggaaacata taatgatttc
    19921 aatacaatgc ttgaggaagc attgaaacca actcttcttt agtaaggagg tagtaaaaat
    19981 tatgtttaac tttttgaaag aatgagacaa tttcaaagta atttacaaac agcaacgaaa
    20041 attgctacga aaatgggatc agcctctgat aggattcaaa gtgcaaccag tcgttctata
    20101 acaaaggaga gtaaaaatga aaatttggga attaaagagt tcatttgatg actatgaatc
    20161 ctttcaacta ttgaacttag aagaagattc taaaaagtat tttgaaggga aaattgactc
    20221 ggcagtaaaa gcatctgatt catggggaga aatacgtatt aaatgtgtag aagaaggaaa
    20281 tcaaagtgat ttgcctcatt tttggggaga agttggtacg ccaatggtta gtgggaaagc
    20341 taaaaaattt ttagagtcta tacttggtga taatgtagaa tttcttcccc taattcatga
    20401 tgtgacggga gaagtgtatt atataattaa cgttttaaat gcactagatg ctattaacta
    20461 tgagaaagct atactaaaga aactacgttc tggcttagta atagatttca aaaaatacgc
    20521 attcttacct aatatggtta agaaccaaac aatatttaaa gtttacttaa atgaaatatt
    20581 acatattcct tccgtttttg tatcagatga atttagaaat acagtgttag aaagtgattt
    20641 aaaaggtttt gaatttatcg aggtatggga ttcagaagca aacatgtaaa agaaagtcct
    20701 aaaataattg ataggagtta gtgacatgga tgtaaaggat ttaaaaattc taagaatgtt
    20761 aaacaattat gagggaaatg aaaaagaaat ttttgaactg attcaagctg aagcaatggt
    20821 gaaatttata tgtggaaaaa tatggtttta gaaattgaaa aaatagagaa aagttttaat
    20881 gataaactga atacaccagc aacagatagt gaagttcaga aattaagaga acgcatgaaa
    20941 gagagttata atgttgacct accgagtgaa tatgaggagt ttcttaaaac tgtagatgga
    21001 ttagatttta acgggctagt actttatgga gttgactctt atttgttaga tacagaaagg
    21061 gacgaatcaa tttgcgggct tatagaaacc aatgagattt ggta
//
