LOCUS       NZ_CP030865            22304 bp    DNA     circular CON 14-AUG-2024
DEFINITION  Micromonospora sp. B006 chromosome, complete genome.
ACCESSION   NZ_CP030865
VERSION     NZ_CP030865.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora sp. B006
  ORGANISM  Micromonospora sp. B006
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 7040153)
  AUTHORS   Braesel,J., Crnkovic,C.M., Kunstman,K.J., Green,S.J.,
            Maienschein-Cline,M., Orjala,J., Murphy,B.T. and Eustaquio,A.S.
  TITLE     Complete Genome of Micromonospora sp. Strain B006 Reveals
            Biosynthetic Potential of a Lake Michigan Actinomycete
  JOURNAL   J Nat Prod 81 (9), 2057-2068 (2018)
   PUBMED   30110167
REFERENCE   2  (bases 1 to 7040153)
  AUTHORS   Braesel,J., Crnkovic,C.M., Kunstman,K.J., Green,S.J.,
            Maienschein-Cline,M., Orjala,J., Murphy,B.T. and Eustaquio,A.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2018) Medicinal Chemistry and Pharmacognosy,
            University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL
            60607, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 77.6x
            Sequencing Technology :: Illumina; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003408515.1-RS_2024_08_14
            Annotation Date                   :: 08/14/2024 03:31:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,342
            CDSs (total)                      :: 6,278
            Genes (coding)                    :: 6,199
            CDSs (with protein)               :: 6,199
            Genes (RNA)                       :: 64
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 20 of 79
            Pseudo Genes (incomplete)         :: 62 of 79
            Pseudo Genes (internal stop)      :: 6 of 79
            Pseudo Genes (multiple problems)  :: 7 of 79
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:07:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6824989
            Orig. end                         :: 6847293
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22304
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="25"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..22304
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22304
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12304](+)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12304
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     misc_feature    548..563
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.03"
                     /tool="antismash"
     gene            complement(1610..3340)
                     /locus_tag="MicB006_RS30635"
                     /old_locus_tag="MicB006_6119"
     CDS             complement(1610..3340)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286158.1"
                     /locus_tag="MicB006_RS30635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6119"
                     /product="cellulose binding domain-containing protein"
                     /protein_id="WP_116510782.1"
                     /transl_table=11
                     /translation="MKRHRTTRTAVLSAGAVLLASTAMAAALPAGAAAAGCAVTYAVSS
                     QWQGGFGANVTVTNLGDPVNGWTLTWSYAAGQTVTQAWNATVTQSGAAVSARNVDYNGS
                     IPTNGSTSFGFNGSWTSSNPAPTSFALNGVTCTGGTTPTSPSTSPSTSPTSSPTTSPSS
                     PPPTGAADITVNTASRYQTIDGFGAAVSIWGGAWSTAETQTLVGLGPNQLGLSIVRTGI
                     SPVSGEWGTQVSALRTAKSYGSNVKIMASPWTAPAAWKTNNSRINGGKLRTDYYDDYAN
                     HLNSYVQYMRNQGVTVDVTSVQNEPDWHPDYDSMDWSGTELQTFVREQGAKVQNTKLMV
                     AEAVNLNYSYTDPTLNDAAARNNIGYIGGHLYGTEASGRLKPYTLAQQYNKPVWMTEWN
                     LHEADGGGSNIWGNPANAAAWNETLDDIMRTVHKSMESNWSAYVWWYGKRYYSFIGDGE
                     SAYGTVAGAPLKRGYAFSQYSKYVRPGYQRVALTKSSKASPLEVTAYSGDGKVTLVILN
                     RSTSAVNNAIIQAPQNVSRAEYVATSQNASAASQPVGVNGNQVTVNVGARSISTVVLTL
                     "
     gene            complement(3368..4909)
                     /locus_tag="MicB006_RS30640"
                     /old_locus_tag="MicB006_6120"
     CDS             complement(3368..4909)
                     /GO_function="GO:0046556 - alpha-L-arabinofuranosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046373 - L-arabinose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289089.1"
                     /locus_tag="MicB006_RS30640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6120"
                     /product="non-reducing end alpha-L-arabinofuranosidase
                     family hydrolase"
                     /protein_id="WP_116510783.1"
                     /transl_table=11
                     /translation="MFAFGRSPSTVSPPRRRGWLPRVVATGAAALLVGAGAVAVVSAPA
                     AAASVDTSAWYVLVNRNSGKALDVYNLATNDGARIVQWSRNNGNQQQWQFVDSGGGYYR
                     LKSRLSGKVLDVYNWSTANGGSIVQWSDTNGTNQQFRLADSDSGYIRLINRNSNKVVEV
                     QGASTADGGNIVQYDDWNGANQQWQLVRVDGGGGNPTTAPPTTPPPGGTCNLPSSYRWS
                     STGVLAQPRSGWVSLKDFTVVPYNGQHLVYATTHDTGSSWGSMNFGLFSNWSQMASASQ
                     NAMSSGTVAPTLFYFAPRNIWVLAYQWGPTAFSYRTSNDPTNPNGWSSAQPLFTGSISG
                     SGTGPIDQTLIADDQNMYLFFAGDNGKIYRSSMPIGNFPGSFGSNYTTIMSDSTNNLFE
                     AVQVYKLQGQTRYLMIVEAIGSQGRYFRSFTATSLGGSWTPQAATESNPFAGKANSGAT
                     WTNDISHGELIRTTADQTFTVDPCNLQLLYQGRSPSSGGDYGLLPYRPGLLTLQR"
     misc_feature    4922..4937
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     misc_feature    4935..4950
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.09"
                     /tool="antismash"
     gene            5217..7262
                     /locus_tag="MicB006_RS30645"
                     /old_locus_tag="MicB006_6121"
     CDS             5217..7262
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477424.1"
                     /locus_tag="MicB006_RS30645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6121"
                     /product="hypothetical protein"
                     /protein_id="WP_225980579.1"
                     /transl_table=11
                     /translation="MIRDWFSVPRVSAEDRAAVFGVRTQDPRVEFVALTVKYWMDAHAT
                     RSMTRDRVLTAMSGRITTDNVWDLVAMLAKLRLAEAFFDLAASDVDTDGAFRRHLLGLD
                     PALLDAMRHYAAWNGINPKLFLDGFAVGVGESVATVVVDLGKLVQLIGRLQQEQFTTLI
                     VLTVDPRAGVQRIADQATVVRQALAGIVAALDPTTVPERLLALWRGWAAEFARHLENLD
                     PFAAGRLLGRVAGDLYQVLTGLVHLARLLGGVAVRAAVRYVPLLLAGAREARLLTAQMA
                     ALLVAIGRAAIAATPRVGLAVLRTLFPPKVLDALFRQGRVLLADAELTLSVFTQAAHAE
                     AFAGAGAGTRLGALVSLDGRPVLMASMSETVSSAGRAATRAELNEALDEIIKRVEDLRE
                     LKPPKTPRDIQAAVVRAAIARQLEQRLTTAFNRALQTAAYEEFRALRKAGQAQPWRLGQ
                     QVHRRMAAEVAQLVGRSPGLEAFAEKSLATVVEAVRAAHPELAPALRGSEAVLRQTVAQ
                     MLLGHPDRDLLLRLVGFTGNPAAAGAEKALAGHLAERFRWKASTTVGDLRSDLLLVDPD
                     AARVTNVDWTSSTKLERFEKTWGTVADDLGETFDGRWEAIAEAYQRAAKGGVPAEVVAG
                     LEELTAHAVRETVVRQAALSQLFPGFFVTSHEMTYQGLHSLFTLPL"
     gene            7273..9534
                     /locus_tag="MicB006_RS30650"
                     /old_locus_tag="MicB006_6122"
     CDS             7273..9534
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289091.1"
                     /locus_tag="MicB006_RS30650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6122"
                     /product="hypothetical protein"
                     /protein_id="WP_116510785.1"
                     /transl_table=11
                     /translation="MGRVVVADADPATLGFSTAHSDRYVYSNYFVPVRLTFGGGETPIL
                     PFYVKQALIEAIRYGGLDGDRLPHLLKQLGLYDLWKANEMDAATEALPGADSGMSYREP
                     PARRQTLLGDQQAEFVAGLLQSDVGIAFLDRTRIRPVGFALGEHVYALALAPGEEAVLE
                     QRTYTKRELTLEEQNESEQQTDVELTSALTTELQEGFERQKSLTDTWGLNASHTGQYTS
                     PTGIWGTFNASHTIGFASSVTAASQETSRRAVKDSRTATSKVAARYRTQHKTDFKLVSE
                     TGTESSSKRTVRNPNRATPITLHYFKVLQRLELAHERYGARVCWAPTIKDPAFAFAQKI
                     VDGRQRIRDNAVAALPPMPVKPERPPRGAPAAVETRVVYSPVVTLDKWGFTGDMSADYD
                     VDVPVDAGWEWDGNVDTIRQNLTLITRRPPDAIAARVVGVPVVTEADGRPVLRVRVHVG
                     ARSWLAGPGADVQLAAGFRRTPTVVDQTADDAAYNALVAGYLTDLQEWQDRRDAALAAA
                     QTAGDEFEARLRAGFSPVNEMVSQIVEAHFPASVRDEAWEIDFWHRVFDWERASFVAYP
                     GWWSGGDARAPERDPGDFVNASWAKLYLPVRAGMELTALRWIFGKVVATSLAPQVEHEL
                     KAFVDELTAYRTGHLGTGDEMPELTTECQDVPERVYCLAKWTELMPTDGTHLEVVQGAT
                     TAADAVTAKEISDAEALRAALLDGEVQTNRLRTKAYDQMTEPADVGIHLGTPSGSGPAA
                     "
     misc_feature    complement(9628..9643)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            9821..9994
                     /locus_tag="MicB006_RS32130"
                     /old_locus_tag="MicB006_6123"
     CDS             9821..9994
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289092.1"
                     /locus_tag="MicB006_RS32130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6123"
                     /product="hypothetical protein"
                     /protein_id="WP_184680028.1"
                     /transl_table=11
                     /translation="MTTAPLRQEEPPVSLGKVRAEPLDRLSAADISPIVRRVMAAHLDQ
                     TRIPAAKFGSFI"
     gene            10001..12304
                     /locus_tag="MicB006_RS30655"
                     /old_locus_tag="MicB006_6124"
     CDS             10001..12304
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289093.1"
                     /locus_tag="MicB006_RS30655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6124"
                     /product="FxsB family cyclophane-forming radical SAM/SPASM
                     peptide maturase"
                     /protein_id="WP_116510786.1"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 1.6e-177,
                     bitscore: 588.4, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.8e-65, bitscore:
                     219.9, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.2e-13, bitscore: 48.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.1e-05, bitscore: 22.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPGPARAALTEFVLKVHARCDLACDHCYVYEHADQSWRRRPVRM
                     TPDVLRAAAGRIAEHAAAHGLPDVTVVLHGGEPLLLGPDGLGQVLAELRRVIGPVTRLR
                     MGMQTNGVLLSERFCDLLAEHDVAVGVSLDGDRAANDRHRRFRSGASSYDQVLRALALL
                     RRPAYRRLWSGLLCTVDVRSDPVAVYEALLAQEPPRIDFLLPHGTWDNPPWRPAAGDTA
                     YARWLRAVHDRWRADGRPVPVRLFDSLLSTARGGPSGTEWLGLDPIDLAVIETDGEWEQ
                     ADSLKTAYDGAPATGMTVFSHTADDVAASALLARRRSGRAGLSDECRRCPVVDQCGGGL
                     FAHRYGAGHFDNPSVYCADLKELIVHVNENPPEPVRLDAGLPDDFIDRLAALTGDRVAI
                     GRLVEAQIAIVHALLAEVADPLPTGGAGADGWAALTALDRSAPESVARIAAHPYVRAWA
                     VDCLAGTGTGARQGPDYLSAIAAAAALDAGTPVHLAVPVRGGRLHLPTVGTVLLPEVAD
                     GTARVEIGPDSLRVRAGDVTVAVNPGTAGGPRWWPTRRLVAQDVSVLLEDGDPHRDCHR
                     LPAGDRLGDEGAARWAATFAAAWQVIRDEVPGHAEELRAGLRAVVPLRRSGAGVSEAST
                     ARQAFGGVAATETDAGSLAVLLVHEFQHSKMNALLDVCDLVDGTRPIDITVGWRPDPRP
                     AEAVLHGIYAHAAVADIWRIRTDRQVDGAQAVYRRYRDWTAEAIGALQRADALTPAGSR
                     LVRQVARSMSGWPS"
     gene            12301..13104
                     /locus_tag="MicB006_RS30660"
                     /old_locus_tag="MicB006_6125"
     CDS             12301..13104
                     /codon_start=1
                     /gene_functions="resistance (resist) AAC3"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289094.1"
                     /locus_tag="MicB006_RS30660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6125"
                     /product="aminoglycoside N(3)-acetyltransferase"
                     /protein_id="WP_116511994.1"
                     /transl_table=11
                     /translation="MTAVRTAHPAGTLAADLRALGLGPGDVVLVHCSLRALGPVAGGPA
                     TLAAALRAAVGPSGTVVVPAQTPDNSVSSPAYHAATAGLTDGERLAYEERMPGFDPAVT
                     PSFGVGAFAEHVRRLPGAVRSRHPQTSFSAWGPRAEELMRVHDLDSHLGERSPLAALEA
                     AGARTLLLGVGYATCTALHLAEYRLRRPPQRRPYRCYVVRDGRRERLDFEAPHLDAAPF
                     PAIGAELDRAAFTRHGTVGGAPARLLPISDAVRTAVAWMDAHIGR"
     gene            13234..14424
                     /locus_tag="MicB006_RS30665"
                     /old_locus_tag="MicB006_6126"
     CDS             13234..14424
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788076.1"
                     /locus_tag="MicB006_RS30665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6126"
                     /product="TIR-like protein FxsC"
                     /protein_id="WP_116510787.1"
                     /transl_table=11
                     /translation="MTSERPALPGPPYFFLSYVPPPAHNDRTPGDHWVRRFYHDLNLAI
                     DGRPGDRLRRQGFADFMVRPPEARTERKRIALAEAEVFVPLYSPAYLNRNDSRREREWF
                     RQRLIRAGRQPDGDNILPVLWIPSPAAVHAPDQTRALAMAADVEAYAANGMSALCRLQK
                     FQHAYKEVLGRLAQHIVDTAEQTPLQPAEPPTGPTDLPSSPPSEVPFRAVVIAPEQPGD
                     PGRLNGRSDTHAGRWRPFRGRPPVVDDVADAVQRLRMPIDVRDFVPDAGLFRACPGVLM
                     IDPRVVETPDGAEAVQAAVDCLHSWVGVVLISEDARPGHRSHAAGLLDRAASILSATTR
                     PLMITTWDAWRTEIHDLVRRMRRRYLEAGPNYPPPGPPINKPRLWENPPPDEGVDT"
     misc_feature    13390..13392
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14421..18356
                     /gene="fxsT"
                     /locus_tag="MicB006_RS30670"
                     /old_locus_tag="MicB006_6127"
     CDS             14421..18356
                     /codon_start=1
                     /gene="fxsT"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477426.1"
                     /locus_tag="MicB006_RS30670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6127"
                     /product="FxSxx-COOH system tetratricopeptide repeat
                     protein"
                     /protein_id="WP_116510788.1"
                     /transl_table=11
                     /translation="MTRREGQVVTFYSYKGGTGRTMALANVAWILAANGKRVLAVDWDL
                     ESPGLSRFFAPFIDRDALESTGGVIDLIREYEWATTTKQDKGDDRWHEQYARVHKYSFS
                     LNWSNFPGDGTLDFLGAGQQNNDYAGALAGMNWDEFYERQGGGYFFDALRADMKRNYDY
                     VLIDSRTGFSDVADICTIQLPDVLVTCFTLSEQGITGAAKVARLVEHRYGSRRIRVLPV
                     PMRIDPAEKVKADTGRAVARQRFSGLPSGMSEAERDRYWARMQVPYQAFYAYEELLATF
                     ADQPGVNGSLLSAYEALTREITRGEVESLPSMSSAVRERVNARFTRTSNSVENEILLRH
                     APYDRVWAEWIGHLLVSADVRVTDPWFTDDETPRTARELIIVSEANATEEAVLAAPDRS
                     PDQVPLVVYVADVRRLANVPAAHTVSVAGLEAQTAAARILRLVGREGVSADLELPTGPR
                     FPGRDNTVFEVPGRNKRFTGREADLRELRTLLRSSPKVVLSGTGPVALQGMGGIGKSQL
                     ALEYAHRYRAAYDMVWWIDADQVPFIESAIGDLAPYLGVPSSESNRENARLVLQALRRT
                     DLRWLLIMDNADEIEGVLPYVPDGKGHVLITSRNLQWVERATTVQVDVFKRAESIQHLT
                     ERVPTMRVDQADRIAALLGDLPIAVTAAAAWLADTGHSVDSYLTEIANFGPGAVMEPNS
                     NVSVEATWELSLNHLRTRNPAAYRVLQLCSVFAPEISADLVYSDEFAEALVPFHPQAKE
                     RLVRQQLVQQANRLALVRVDLRAESPSGGERGRGGLVLMHRLLQHAVRSRMTEEELDEA
                     RRQVHLVLAAARPEGEVDDPDGWPRFRVIWPHLEASKAPLSHRVEVRALMIDRVRYLQL
                     RGDLETGRRLGEEVAQTWEQMLAEETDARARDDLRRQLLHLQFNLANILAFLGQFQQSR
                     ALDEEVLAAQRELLGEDHPHTLMTAGGLARDLRGMGKYNEALRLDEITFNAWKRNFTEE
                     HPRTLVALNNLATTQRLMGDFREARKNDEMVLAGRRAILGEDHPDTLASSAYVGIDMRD
                     AGDYEQSIARLRGVHRDLLRTAGAEHLMTLRAQTNLAVSLRSAGHAVEAGKLLEAAYEL
                     LNERFGPDNPETLTCRLSLSVNLLSVDLFQRASRELTEVHRVYQQNLGPEHPLTLVCMV
                     NLAMVARRAGDFAEARQLAGRSADALADVLGSDHPYPLSGWMNQGICIAEQPDPPEGRE
                     AADLEALGLLRRADDGLTRMLGRDHPNTLRSRANLVVMQERMESGRRAELEAVTRELAY
                     RLGENHPAVEAVRENQLQRRIIDPHPI"
     gene            complement(18334..19254)
                     /locus_tag="MicB006_RS30675"
                     /old_locus_tag="MicB006_6128"
     CDS             complement(18334..19254)
                     /NRPS_PKS="Domain: Abhydrolase_1 (30-279). E-value:
                     1.6e-20. Score: 65.7. Matches aSDomain:
                     nrpspksdomains_MicB006_RS30675_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289097.1"
                     /locus_tag="MicB006_RS30675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_6128"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_116510789.1"
                     /sec_met_domain="PF00561 (E-value: 3.8e-17, bitscore: 61.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.7e-10, bitscore:
                     40.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHSPPHREHIVRTGRRNLAVDIAGAKHGWPVFLMHGTPGSRNGP
                     RPRSIVLHRLGVRLISYDRPGYGGSSRLPGRRIADAAADVAAIADDLGLDGFSVVGRSG
                     GGPHALACAALLPERVRRTAVLVGLAPAGAAGLDWFGGMTDANVRDYGAAERAVPVLAE
                     QLRLRAERTMDDPGSLLALLVEQMTAADRRVVAGVPIRRQLTDAYAEALRQGPHGWIDD
                     VLALRADWGVTLADIRMPVRLWHGADDNFAPASHTRWLAEQIPGAQLHVQPRSAHFGAV
                     EVLPEILAWLAGPVERAAVRSDAGR"
     aSDomain        complement(18418..19164)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MicB006_RS30675_Abhydrolase_1.1"
                     /evalue="1.60E-20"
                     /label="MicB006_RS30675_Abhydrolase_1.1"
                     /locus_tag="MicB006_RS30675"
                     /protein_end="279"
                     /protein_start="30"
                     /score="65.7"
                     /tool="antismash"
                     /translation="PVFLMHGTPGSRNGPRPRSIVLHRLGVRLISYDRPGYGGSSRLPG
                     RRIADAAADVAAIADDLGLDGFSVVGRSGGGPHALACAALLPERVRRTAVLVGLAPAGA
                     AGLDWFGGMTDANVRDYGAAERAVPVLAEQLRLRAERTMDDPGSLLALLVEQMTAADRR
                     VVAGVPIRRQLTDAYAEALRQGPHGWIDDVLALRADWGVTLADIRMPVRLWHGADDNFA
                     PASHTRWLAEQIPGAQLHVQPRSAHFG"
     misc_feature    19502..19516
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(21906..21920)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
ORIGIN
        1 ctgcgactcc acgcggcact ggccacggcg gtcgtgggga tcgccgtcgc cgtggcgctc
       61 ccgtccccgc aggcgtcggc ggcggccggc agcgccaccg gctacgccac ccagaacggc
      121 ggcgccaccg gcggcgcggg cgggcagacg gtacgcgcca ccaccggcac cgccatccac
      181 gccgcgctgt gcgggcgggc cagcagcagc accccgatca tcatcgaggt gaccgggacc
      241 atcaaccacg gcaacaccag caaggtctcc ggatcgagct gcaacaccgc cgacggcgtg
      301 atcgagctga agcagatcag caacgtcacc atcatcggcg tgggcagcgg cgccgtcttc
      361 gaccagctcg gcatccacat ccgcgactcg cgcaacatca tcatccgcaa cgtgacggtg
      421 cgcaacgtca agaagtccgg ctcgcccacc tccaacggcg gtgacgcgat cggcatggag
      481 agcagcgtcc gcaacgtctg ggtcgaccac gtgacgctgg aggcgtccgg cggggagtcg
      541 gagggctacg acggcctgtt cgacatgaag gacgacactc agtacgtgac gctgtcgtac
      601 agcatcctgc gcaactccgg ccggggcggc ctcatcgggt ccagcgagag cgaccgcggc
      661 aacggctaca tcacgttcga gcacaacctg tacgagaaca tcgactcccg tacgccgctg
      721 ttgcgtggcg gcatcgccca catgttcaac aaccactaca ccgggctgca cgagtcgggc
      781 atcaactccc gggccggcgc gcgggccaag gtggacaaca actacttccg caactccaag
      841 gacgtgctcg gcacgttcta caccagcgag cgcggcacct ggcaggtcag cggcaacatc
      901 ttcgacaacg tgacctggtc ctcgcccggg agcgacaact acccggcggg gccgaacgtg
      961 acgtccacga ccaccgtcag cgtgccgtac tcgtaccgtc tggacgcggc gagctgcgtg
     1021 ccggacgtcg tgcggcagac ggcgggcccg aacaccggcc tgcgcgtctc cgacggcaac
     1081 tgcacgccgc agtccccgac cccgaccact cccgcaccca ccacgcccgc acccaccacg
     1141 ccgccgcccg ggacgaccac cccgcccccg tccggcggga ccaacctgag cctcctctcc
     1201 ggggccggcg ccgacgggtc cagcaaggcc gacggcacca gctacggcaa cgtgcgcgac
     1261 ggcagcctga gcacctactg gtcgccgtcc ggatccaccg gcaccgtctc gatcaagtgg
     1321 gggtcggcca ccaccgtgtc ccgcgtggtc atccgcgagc cgtccggcac ctcgggctcg
     1381 atcgggtcct ggcagctcgt caacaacgac accggcgcgg tgctggcctc cggcagcggg
     1441 gctggccaga tcaccttcgg cgcgacttcg ctgaagaaga tcaacttcaa gatcaacagc
     1501 tccagcggta cgccgagagt cggcgagttc gagacgtacg ccagttagcg gtcacacacg
     1561 agcgggggcg gccgatccgg ccgcccccgc ccttgtttcg tgtccccggt cagagggtga
     1621 gcacgacggt ggagatgctt cgcgcgccga cgttcacagt gacctggttg ccgttcacgc
     1681 cgaccggctg gctcgccgcg ctggcgttct gcgacgtggc cacgtactcc gcccggctga
     1741 cgttctgcgg cgcctggatg atcgcgttgt tcaccgcgct ggtggaccgg ttgaggatca
     1801 ccagcgtgac cttcccgtca ccggaatagg cggtcacctc cagcggcgac gccttggagc
     1861 tcttggtcag ggcgacccgc tggtagccgg gccgcacgta cttcgagtac tgcgagaacg
     1921 cgtacccgcg cttgagcggc gcgcccgcca cggtgccgta cgcggactcg ccgtcaccga
     1981 tgaacgagta gtagcgcttg ccgtaccacc agacgtacgc gctccagttc gactccatcg
     2041 acttgtgcac ggtgcgcatg atgtcgtcga gcgtctcgtt ccaggccgcg gcgttggccg
     2101 ggttgcccca gatgttggag ccgccgccgt cggcctcgtg caggttccac tcggtcatcc
     2161 acaccggctt gttgtactgc tgcgccagcg tgtacggctt cagccggccg gacgcctcgg
     2221 tgccgtacag gtgaccgccg atgtacccga tgttgttgcg ggccgccgcg tcgttgagcg
     2281 tcgggtcggt gtagctgtag ttcaggttca ccgcctcggc gaccatcagc ttggtgttct
     2341 gcaccttggc gccctgttcc cggacgaagg tctgcagctc ggtgccgctc cagtccatcg
     2401 agtcgtagtc cgggtgccag tccggctcgt tctgcacgga cgtgacgtcg accgttacgc
     2461 cctggttgcg catgtactgg acgtagctgt tgaggtggtt ggcgtagtcg tcgtagtagt
     2521 cggtgcgcag cttgccgccg ttgatccggc tgttgttcgt cttccaggcc gccggagcgg
     2581 tccacggcga cgccatgatc ttcacgttcg acccgtacga tttcgccgtg cgcagcgcgc
     2641 tgacctgggt tccccactcg ccggacaccg gcgagatgcc ggtacgcacg atggacaggc
     2701 cgagctggtt ggggccgagc ccgacgagcg tctgcgtctc ggccgtcgac caggcgccgc
     2761 cccagatcga cacggcggcg ccgaacccgt cgatcgtctg gtagcggctg gcggtgttga
     2821 cggtgatgtc cgccgccccg gtgggcggcg ggctgctcgg cgaggtggtc ggcgaactcg
     2881 tcggcgacgt ggacggcgag gtggacggcg acgtcggcgt cgtgccgccg gtgcaggtca
     2941 cgccgttgag cgcgaagctg gtcggcgcgg ggttgctgct ggtccaggac ccgttgaacc
     3001 cgaacgacgt gctgccgttc gtcgggatgg acccgttgta gtcgacgttg cgggcgctga
     3061 ccgccgcccc gctctgggtg actgtggcgt tccacgcctg ggtgacggtc tggccggcgg
     3121 cgtaggacca ggtgagcgtc cagccgttga ccgggtcacc gaggttggtg accgtgacgt
     3181 tcgcgccgaa gccgccctgc cactgcgacg acacggcgta ggtcaccgcg catccggcgg
     3241 ccgccgcccc ggccggtagc gccgcggcca tcgcggtgga cgccagcagg accgcgccgg
     3301 ccgacaacac cgcggtacgg gtcgttctgt gccttttcat gcgaccttct ctcctcgacg
     3361 gcccggctca gcgctggagg gtgagcagtc cggggcggta gggcaggagg ccgtagtcgc
     3421 cgccggagct gggggaacgg ccctggtaga gcagttggag gttgcagggg tcgacggtga
     3481 aggtctggtc ggcggtggtg cggatcaact caccgtggct gatgtcgttg gtccaggtgg
     3541 cgccgctgtt ggccttgccg gcgaaggggt tggactcggt ggcggcctgc ggggtccagg
     3601 agccgcccag gctggtggcg gtgaacgacc ggaagtagcg gccctgcgag ccgatcgcct
     3661 cgacgatcat caggtagcgg gtctggccct gcagcttgta gacctgcacg gcttcgaaca
     3721 ggttgttcgt cgagtccgac atgatcgtgg tgtagttcga gccgaagctg ccggggaagt
     3781 tcccgatcgg catgctggag cggtagatct tgccgttgtc accggcgaag aacaggtaca
     3841 tgttctggtc gtcggcgatc agggtctggt cgatcgggcc ggtgccggag ccggagatgc
     3901 tgccggtgaa cagcggctgc gccgaggacc atccgttggg gttggtgggg tcgttggagg
     3961 tgcggtagga gaacgcggtg ggtccccact ggtaggccag gacccagatg ttgcgcggcg
     4021 cgaagtagaa cagcgtcggc gcgacagtgc cggaggacat cgcgttctgc gaggcggagg
     4081 ccatctgcga ccagttggag aacagaccga agttcatcga cccccacgac gacccggtgt
     4141 cgtgcgtggt ggcgtagacg aggtgctgcc cgttgtaggg caccactgtg aagtccttga
     4201 gcgacaccca gcccgagcgc ggctgcgcca acacgcccgt ggacgaccac cggtacgacg
     4261 acggcaggtt gcacgtacca cccggcggcg gagtggtggg cggcgccgtg gtggggttgc
     4321 caccgccgcc gtcgacgcgg acgagctgcc actgctggtt ggcgccgttc cagtcgtcgt
     4381 actggacgat gtttccgccg tcggcggtcg aggcgccctg cacctccacc accttgttgc
     4441 tgttgcggtt gatcaggcgg atgtacccgc tgtcggagtc ggccagccgg aactgctggt
     4501 tggtcccgtt ggtgtcggac cactgcacga tgctgccgcc gtttgcggtc gaccagttgt
     4561 agacgtcgag caccttgccg gacagccggg acttcagccg gtagtagccg ccgccggagt
     4621 cgacgaactg ccactgctgc tggttgccgt tgttgcgcga ccactgcacg attcgcgcgc
     4681 cgtcgttcgt ggccaggttg tagacgtcga gcgccttgcc gctgttgcgg ttgaccagga
     4741 cgtaccaggc actcgtgtcg acgctcgcgg cggcggcggg cgcggacacg accgccacgg
     4801 cgccggcgcc gacgaggagc gccgcggcgc ctgtcgcgac gactcgcggc agccatccgc
     4861 gccgtcgtgg cggcgacacc gtcgatgggg atctaccaaa agcaaacatg ttcctccctc
     4921 agatcacatt tgtgagcgct aacaattagc gctggcgcac tgaccccaca cccggcctgc
     4981 cacccggccg cccgcgcccg ctcggcgacc cgtcgctgcc gccgcgctgt gccatcgact
     5041 gtgagcgata acacgtcgtt cgtcaagtcg taacagtcga tggatgccgg gcccgacggc
     5101 cacggaggtc atgtcggctt gtcgacccag cactagcgac gcccgtatcg cggcccgaca
     5161 gtgcacacgg ctggagggcg gtgggggatt tggggcagcc ggcggacgaa tccgtcatga
     5221 tccgggactg gttcagcgtg ccgcgggtgt ccgccgagga ccgggccgcg gtcttcggcg
     5281 tacgcaccca ggacccgcgg gtggagttcg tcgcgctgac cgtcaagtac tggatggacg
     5341 cccacgccac ccggtcgatg acccgcgacc gggtcctgac cgcgatgagc ggccgcatca
     5401 ccaccgacaa cgtctgggac ctggtcgcga tgctcgcgaa actgcggctg gccgaggcgt
     5461 tcttcgacct ggccgcctcc gacgtcgaca ccgacggcgc gttccgccgc cacctgctcg
     5521 gcctcgaccc cgcgctgctc gacgcgatgc ggcactacgc ggcctggaac gggatcaacc
     5581 cgaagctgtt cctcgacggg ttcgcggtgg gtgtcgggga gtccgtcgcg acggtggtgg
     5641 tcgacctcgg caagctcgtg cagttgatcg gccggctcca gcaggaacag ttcaccacgc
     5701 tcatcgtgct gacagtcgat ccccgcgccg gtgtgcagcg catcgccgac caggccacag
     5761 tcgtacgcca ggcgctggcc gggatcgtgg ccgcgctgga cccgacaacc gtcccggaac
     5821 ggctgctggc gctgtggcgc ggctgggcgg ccgagttcgc ccggcacctg gagaacctcg
     5881 acccgttcgc cgccggccgg ctgctcgggc gcgtcgccgg cgacctgtac caggtgctca
     5941 ccggactggt acatctcgcc cggctgctcg gcggcgtcgc ggtgcgcgcc gccgtccggt
     6001 acgtgccgct gctgctcgcg ggcgcccgcg aggcacgcct gctgaccgcc cagatggccg
     6061 cgctgctggt ggcgatcggc cgggccgcga tcgccgccac gccccgggtg gggctggccg
     6121 tcctgcgcac gctcttcccg ccgaaggtgc tcgacgcgct gttccggcag ggccgggtgc
     6181 tgctggccga cgccgaactg acgctgagcg tgttcaccca ggcggcgcac gccgaggcgt
     6241 tcgcgggcgc cggggcgggc acccggctcg gcgcgctggt cagcctcgac ggccggcccg
     6301 tgctgatggc gagcatgtcc gagacggtgt cctcggccgg ccgggcggcg actcgcgccg
     6361 aactgaacga ggcgctggac gagatcatca agcgggtcga ggacctgcgc gagctgaagc
     6421 cgccgaagac accccgggac atccaggccg ccgtcgtgcg cgcggccatc gcccggcaac
     6481 tggagcagcg gctgaccacc gcgttcaacc gggcgctcca gaccgccgcg tacgaggagt
     6541 tccgcgcgct gcgcaaggcc gggcaggcgc agccctggcg gctcgggcag caggtgcacc
     6601 ggcggatggc cgccgaggtc gcccagctcg tcggccggtc accgggcctc gaggcgttcg
     6661 cggagaagtc gctggcgaca gtggtcgagg cggtccgcgc ggcccatccg gaactggcgc
     6721 ccgcgctgcg cggctccgag gcggtgctgc gccagacggt cgcccagatg ctgctcggcc
     6781 acccggaccg ggacctgctg ctgcgcctcg tcgggttcac cggcaacccg gccgcggccg
     6841 gggcggagaa ggccctcgcc ggccacctcg ccgagcggtt ccggtggaag gcgtccacca
     6901 ctgtcgggga cctccgttcc gacctgctgc tcgtcgaccc cgatgcggcc cgcgtcacga
     6961 acgtcgactg gacctcctcg accaagctgg agcgcttcga gaagacctgg ggcaccgtcg
     7021 ccgacgacct cggggagacg ttcgacggtc gctgggaggc gatcgcggag gcgtaccagc
     7081 gggccgccaa gggcggtgtg ccggcagagg tcgtcgccgg tctcgaagag ctgaccgcgc
     7141 acgccgtacg cgagacggtc gtccggcagg ccgccctcag tcagttgttc cccgggttct
     7201 tcgtcacctc gcacgagatg acgtaccagg ggctgcactc cctgttcacc ctgccgctgt
     7261 agaggagcac cgatgggcag agtcgtcgtc gccgacgccg atccggcgac gcttggtttc
     7321 agcaccgcgc attccgaccg gtacgtctac tcgaactact tcgtaccggt ccggctcacg
     7381 ttcggcggtg gcgagacgcc catcctgccg ttctacgtca agcaggcgct gatcgaggcg
     7441 atccgctacg gcgggctcga cggcgaccgg ctgccccacc tgctcaagca actcggcctc
     7501 tacgacctgt ggaaggccaa cgagatggac gccgccaccg aggcactgcc cggcgccgac
     7561 tcgggcatgt cgtaccggga gccgccggcg cggcgccaga cgctcctcgg cgaccagcag
     7621 gcggagttcg tcgccgggct gctccagtcc gacgtgggca tcgcgttcct cgaccgcacc
     7681 cggatccggc cggtgggctt cgcgctcggc gagcacgtct acgcgctggc gctcgccccc
     7741 ggtgaggagg cggtgctgga gcagcgcacc tacaccaagc gcgagctgac cctggaggag
     7801 cagaacgagt cggaacagca gaccgacgtc gagctgacca gcgcgctcac cacggaactc
     7861 caggagggct tcgagcggca gaagtcgctc accgacacct gggggctcaa cgcgagccac
     7921 accggccagt acaccagccc gaccggcatc tggggcacct tcaacgccag ccacacgatc
     7981 ggcttcgcca gcagcgtcac cgcggcgagc caggagacga gccgccgcgc ggtcaaggac
     8041 agccggaccg ccacctcgaa ggtcgccgcg cgctaccgca cccagcacaa gaccgacttc
     8101 aagctggtca gcgagacggg tacggagtcg tcctcgaagc gcaccgtccg caacccgaac
     8161 cgggccacgc cgatcacgct gcactacttc aaggtgctgc aacggctgga gctggcccac
     8221 gagcggtacg gcgcacgggt ctgctgggcc cccacgatca aggatccggc gttcgccttc
     8281 gcccagaaga tcgtcgacgg gcggcagcgg atccgcgaca acgcggtcgc cgcactgccc
     8341 ccgatgccgg tgaagccgga gcgcccgccg cgtggcgcgc ccgcagcggt ggagacgcgc
     8401 gtcgtgtact cccccgtggt cacgctcgac aagtggggat tcacgggtga catgagcgcg
     8461 gactacgacg tcgatgtccc cgtcgacgcc ggctgggagt gggacggcaa cgtcgacacg
     8521 atccggcaga acctcacgct gatcacccgc cgtccgccgg acgcgatcgc cgcccgggtg
     8581 gtgggcgtgc cggtggtcac cgaggcggac ggacggccgg tgctgcgcgt acgcgtgcac
     8641 gtcggcgccc ggagctggct ggcgggtccg ggcgcggacg tgcaactcgc cgccgggttc
     8701 cggcgtaccc cgacggtggt ggaccagacc gccgacgacg cggcgtacaa cgcgctggtc
     8761 gcgggctacc tgaccgacct tcaggagtgg caggaccggc gcgacgcggc gctggcggcg
     8821 gcccagacgg cgggggacga gttcgaggcg cggctacggg ccggcttctc gccggtcaac
     8881 gagatggtct cgcagatcgt ggaggcgcac ttcccggcca gcgtgcggga cgaggcgtgg
     8941 gagatcgact tctggcaccg ggtcttcgac tgggagcgcg cgtcgttcgt ggcgtacccc
     9001 gggtggtggt ccggcggtga tgcccgtgcc ccggagcgcg accccggcga cttcgtcaac
     9061 gccagctggg cgaagctcta cctgccggtg cgggccggca tggagctgac cgcgctgcgg
     9121 tggatcttcg gcaaggtggt ggcgaccagc ctcgcgccgc aggtggagca cgagctgaag
     9181 gcgttcgtgg acgagctgac ggcgtaccgg accggccacc tcggcaccgg cgacgagatg
     9241 cccgagctga ccaccgagtg ccaggacgtg ccggagcggg tgtactgcct ggcgaagtgg
     9301 accgagttga tgcccaccga cggcactcac ctggaggtgg tgcagggcgc caccacggcg
     9361 gccgacgcgg tgaccgccaa ggagatcagc gacgcggagg cgctgcgggc ggcgttgctc
     9421 gacggcgagg tgcagaccaa ccggctccgg accaaggcgt acgaccagat gaccgagccg
     9481 gccgacgtcg gcatccacct cggcacgccg tccgggagcg gcccggccgc ctgagccgcc
     9541 ggacgctacc gctcgtccac cccggtccct cgcctgagca ggggatcggg gtggacgatt
     9601 tctggcaaag tctgaacttt cgattcgtgg cctagatggt caaaaaggcg cataattgat
     9661 cccttacggt cgctcccctg agcgacgacg acgccggccg gcgaaccgtc caaaaagaac
     9721 cgtctcccca ccggtgggtt gatggtgctg gatccccaaa ggcactaggt tggccggggc
     9781 cactgtgctc ggctggcgta cacgaaccta aggaagactc atgactaccg cacccttgcg
     9841 ccaggaagag cccccggtgt cgctgggcaa ggtccgcgcg gagccgctcg accggctctc
     9901 cgccgcggac atatccccca tcgtgcgccg ggtgatggcg gctcacctcg atcagaccag
     9961 gatcccggcg gcgaaattcg gctcgttcat ctgacctgcg atgtccccgg ggccggcccg
    10021 cgcggcgctc accgagttcg tcctcaaggt gcacgccagg tgtgacctgg cgtgcgacca
    10081 ctgctacgtc tacgaacacg ccgaccagag ctggcgccgc cgcccggtgc ggatgacgcc
    10141 ggacgtgctc cgggccgcgg ccggacggat cgccgaacac gcggcggccc acgggctgcc
    10201 ggacgtcaca gtcgtcctgc acggcgggga gccgctgctg ctcggccccg acgggctggg
    10261 ccaggtactc gccgaactgc ggcgcgtcat cggcccggtc acccggctcc gaatgggcat
    10321 gcagacaaac ggcgtgctgc tctccgagcg gttctgcgac ctgctcgccg aacacgacgt
    10381 cgcggtcggt gtctcgctcg acggcgaccg ggccgcgaac gacaggcacc ggcgcttccg
    10441 ctccggtgcc agcagctacg accaggtgct gcgggcgctc gccctgctgc gccgcccggc
    10501 gtaccggcgg ctctggtcgg gtctgctctg cacagtggac gtgcgcagcg atccggtagc
    10561 cgtgtatgag gcgctgctcg cccaggagcc gccccggatc gacttcctgc tcccgcacgg
    10621 cacctgggac aacccgccgt ggcggccggc cgccggggac accgcgtacg cccgctggct
    10681 gcgcgccgtc cacgaccgct ggcgcgcgga cggccgcccg gtcccggtgc gcctgttcga
    10741 ctcgctcctg tccaccgccc gcggcggacc cagcggcacg gaatggctgg gcctcgaccc
    10801 gatcgacctg gccgtgatcg agacggacgg cgaatgggag caggccgact cgctcaagac
    10861 cgcgtacgac ggcgcgcccg ctaccggcat gactgtcttc tcgcacacgg ccgacgacgt
    10921 ggcggcgagc gcgctgctgg cccgccgccg ctccggccgg gccggtctca gcgacgagtg
    10981 ccggcggtgc ccggtggtcg accagtgcgg cggcggactc ttcgcccacc ggtacggcgc
    11041 cgggcacttc gacaatccga gtgtctactg cgccgatctg aaagagctga tcgtgcacgt
    11101 gaacgagaac ccaccggaac ccgtccggct cgacgccggc ctgcccgacg acttcatcga
    11161 ccgcctcgcg gcgctgaccg gcgaccgggt cgccatcggc cggctcgtgg aggcacagat
    11221 cgccatcgtc cacgcgctgc tcgccgaggt ggccgacccc ctgccgaccg gcggggccgg
    11281 agccgacggc tgggccgcgc tgaccgccct ggaccgcagc gcgccggaat cagtggcccg
    11341 gatcgcggcg cacccgtacg tgcgggcgtg ggctgtcgac tgcctcgccg gcaccggcac
    11401 cggcgcccgc caggggccgg actacctgag cgcgatcgcc gccgccgctg cgctcgacgc
    11461 cggcacgccg gtacacctgg ccgtgccggt gcgcggcggc cgcctgcacc tgccgacggt
    11521 gggcaccgtc ctgctgcccg aggtggccga cggcaccgcg cgggtggaga tcggcccgga
    11581 ctcgctgcgg gtgcgggccg gggacgtgac agtggcggtg aatccgggca cggcgggtgg
    11641 gccccgctgg tggccgaccc gccgtctcgt cgcgcaggac gtgtcggtcc tgctggagga
    11701 cggcgacccg caccgcgact gccaccggct gcccgccggt gaccggctcg gcgacgaggg
    11761 cgccgcgcgc tgggccgcca cgttcgcggc ggcatggcag gtgatccggg acgaggtccc
    11821 cggccacgcc gaggagctgc gcgccgggct gcgggccgtg gtgccgttgc ggcgcagcgg
    11881 cgccggtgtg agcgaggcgt cgaccgcccg gcaggcgttc ggcggcgtcg cggcgacgga
    11941 gaccgacgcc gggtcgctgg cggtgctgct cgtgcacgag ttccagcaca gcaagatgaa
    12001 cgcgctgctg gacgtctgcg acctggtcga cggcacccgg ccgatcgaca tcactgtggg
    12061 ctggcggccc gacccgcgtc ccgccgaggc cgttctgcac ggcatctacg cgcacgcggc
    12121 ggtggccgac atctggcgga tccggaccga ccgtcaggtc gacggcgcgc aggcggtcta
    12181 ccggcggtac cgcgactgga cggccgaggc gatcggcgcg ctgcaacggg cggacgcgct
    12241 cactccggcc gggtcgcggc tggtccggca ggtcgcccgc tcgatgtccg ggtggccgtc
    12301 gtgaccgccg tccggaccgc gcacccggcc ggcacgctcg ccgccgacct gcgcgcgctc
    12361 gggctcggcc ccggtgacgt ggtgctcgtg cactgctccc tgcgcgccct cggaccggta
    12421 gccggtgggc cggccaccct ggctgcggcg ctgcgggccg ccgtcggtcc gtccggcacc
    12481 gtcgtggtcc cggcgcagac cccggacaac tcggtgagca gccccgcgta ccacgcggcg
    12541 accgccgggc tgaccgacgg ggaacgcctg gcgtacgagg aacggatgcc cggcttcgac
    12601 ccggccgtca ccccgtcgtt cggggtcggc gcgttcgccg agcacgtacg ccgcctgccc
    12661 ggcgcggtcc gcagccggca cccgcagacg tcgttcagcg cgtgggggcc gcgggcggag
    12721 gagctgatgc gcgtccacga cctggactcc cacctcgggg agcggtcccc gctcgccgcc
    12781 ctggaggcgg ccggtgcccg gacgctgctg ctcggtgtcg gttatgcgac atgcaccgcg
    12841 ctgcacctcg ccgagtaccg gttgcgccgc ccgccgcagc ggcgtccgta ccgctgctac
    12901 gtggtgcgcg acggccgccg ggaacggctc gacttcgagg cgccgcacct ggatgcggcc
    12961 cctttccccg caatcggcgc ggaactcgac cgggcggcgt tcacccggca cgggacggtc
    13021 ggcggcgccc cggcccggct gctgccgata tccgacgcgg tacgcaccgc cgtcgcctgg
    13081 atggacgccc acatcggacg gtgagggcct ggtaacccga gcgcaacctc tctaccctga
    13141 tcgatagacg ccgtatcgtg tcgactgggg agcagcacgt gatcattgac ggttgggggt
    13201 caggcgctct tcccgtggaa cggtcgggtc gtcgtgacct ctgagcggcc cgcgctgccg
    13261 ggcccgccct atttcttcct cagctacgtc cccccgccgg cacacaacga ccgcaccccg
    13321 ggcgaccact gggtccgccg cttctaccac gatctcaacc tggcgatcga cggccggccc
    13381 ggcgaccggt tacgccggca gggcttcgcc gacttcatgg tgcggccgcc ggaggcccgg
    13441 acggaacgaa aacgcatcgc gctggccgag gccgaggtgt tcgtcccgct gtactcaccg
    13501 gcctacctca accggaacga ctcgcgccgg gagcgggagt ggttccggca acggctcatc
    13561 cgggccggcc ggcagcccga cggcgacaac atcctcccgg tcctgtggat cccgtcgccg
    13621 gccgccgtcc acgcgccgga ccagacgcgc gcgctggcga tggccgccga cgtggaggcg
    13681 tacgccgcga acggcatgag cgcgctctgc cggctccaga agttccagca tgcctacaag
    13741 gaggtgctgg gccggctcgc ccagcacatc gtcgacaccg ccgagcagac gccgctgcaa
    13801 ccggccgagc cgccgaccgg cccgaccgac ctgccgtcgt ccccgcccag cgaggtgccg
    13861 ttccgggcgg tggtgatcgc acccgagcag ccgggggacc cgggccggct caacggacgc
    13921 tccgacacgc acgccgggcg gtggcgcccg ttccgcggcc ggccgccggt ggtcgacgac
    13981 gtggccgacg cggtgcagcg gttgcggatg cccatcgacg tgcgcgactt cgtaccggac
    14041 gccgggctgt tccgggcctg tccgggcgtc ctcatgatcg atcctcgggt ggtcgagacg
    14101 ccggacggcg cggaggccgt ccaggccgcc gtcgactgcc tgcacagctg ggtgggcgtc
    14161 gtgctgatca gcgaggacgc ccgccccggc caccgctcgc acgcggcggg actgctcgac
    14221 cgggcggcga gcatcctctc cgccacgacg cgtccgctga tgatcaccac gtgggacgcc
    14281 tggcggaccg agatccacga tctagtccgc cggatgcgac gccgatacct ggaggcggga
    14341 ccgaactacc caccgccggg accccccatc aacaagcccc ggctctggga gaacccgccg
    14401 cccgacgagg gagtggacac atgacccgac gtgagggaca ggtcgtcacc ttctactcct
    14461 acaagggcgg caccggccgg acgatggcgt tggccaacgt cgcctggatc ctcgccgcga
    14521 acggcaagcg ggtgctcgcc gtcgactggg atctggagtc ccccggcctg tcgcgcttct
    14581 tcgcgccgtt catcgaccgg gacgcgctgg agagcaccgg cggggtgatc gacctgatcc
    14641 gggagtacga gtgggcgacc accaccaagc aggacaaggg cgacgaccgc tggcacgagc
    14701 agtacgcccg ggtgcacaag tactcgttct cgctgaactg gtccaacttc cccggtgacg
    14761 ggacgctcga cttcctcggc gccgggcagc agaacaacga ctacgcgggc gcgctcgccg
    14821 ggatgaactg ggacgagttc tacgagcggc agggcggcgg ctacttcttc gacgcgctgc
    14881 gcgccgacat gaagcgcaac tacgactacg tgctcatcga cagccgcacc gggttctccg
    14941 acgtcgccga catctgcacc atccagctgc cggacgtgct cgtcacctgt ttcaccctca
    15001 gcgagcaggg catcaccggc gccgcgaagg tggcgcggct ggtcgagcac cggtacgggt
    15061 cgcggcggat ccgggtgctg ccggtgccga tgcgtatcga cccggcggag aaggtcaagg
    15121 cggacaccgg gcgggccgtg gcgcgacagc gtttcagcgg tctgcccagc ggcatgagcg
    15181 aggccgaacg ggaccggtac tgggcccgga tgcaggtgcc ctaccaggcg ttctacgcgt
    15241 acgaggaact cctcgccacg ttcgccgacc aaccaggcgt caacgggtcg ctgctgtccg
    15301 cgtacgaggc gctgacgcgc gagatcaccc ggggcgaggt ggagtcgctg ccgtcgatga
    15361 gcagcgcggt acgcgaacgg gtcaacgccc ggttcacccg cacctccaac tccgtggaga
    15421 acgagatcct gctccggcac gccccgtacg accgggtgtg ggcggagtgg atcggccacc
    15481 tcctggtctc ggccgacgtg cgggtgaccg acccgtggtt caccgacgac gagacgcccc
    15541 ggacggcccg ggagctgatc atcgtctccg aggcgaacgc caccgaggag gcggtgctcg
    15601 ccgcgccgga ccgctcgccc gaccaggtgc cgctcgtcgt ctacgtggcg gacgtgcggc
    15661 gcctggcgaa cgtgccggcc gcgcacaccg tctcggtggc cgggctggag gcgcagaccg
    15721 ccgccgcgcg gatcctgcgc ctggtcggcc gggagggggt gtcggccgac ctggaactgc
    15781 ccaccggtcc ccggttcccc ggccgggaca acacggtgtt cgaggtgccg ggccgcaaca
    15841 agcgcttcac cggccgcgag gcggacctgc gcgagctgcg gacgctgctg cgcagcagcc
    15901 cgaaagtggt gctctccggc accgggccgg tggcgttgca gggcatgggc ggcatcggca
    15961 agagccagct cgcgctggag tacgcccacc gctaccgcgc cgcgtacgac atggtgtggt
    16021 ggatcgacgc cgaccaggtg ccgttcatcg agtcggccat cggtgacctc gcgccctacc
    16081 tgggcgtgcc ctcctcggag tcgaaccggg agaacgcccg gctggtgctc caggcgctgc
    16141 gccgcaccga cctccgatgg ctgctgatca tggacaacgc cgacgagatc gagggcgtcc
    16201 tgccgtacgt gccggacggc aagggccacg tcctgatcac gtcccggaac ctccagtggg
    16261 tcgagcgggc caccaccgtc caggtcgacg tgttcaagcg cgcggagagc atccagcacc
    16321 tcaccgagcg ggtgccgacc atgcgcgtcg accaggccga ccggatcgcc gccctgctcg
    16381 gcgacctgcc gatcgctgtc accgccgccg cggcctggct ggccgacacc ggccactcgg
    16441 tcgacagcta cctcaccgag atcgccaact tcggtccggg cgcggtgatg gagccgaaca
    16501 gcaacgtctc ggtggaggcg acctgggagc tgtccctgaa ccacctgcgt acccggaacc
    16561 cggcggccta ccgggtgctg caactctgct cggtgttcgc gccggagatc tccgccgacc
    16621 tggtctacag cgacgagttc gccgaggcgc tcgtgccgtt ccacccgcag gccaaggaac
    16681 ggctggtccg tcagcagttg gtgcagcagg cgaaccggct cgcgctggtc cgcgtcgacc
    16741 tgcgggccga gagcccgtcc ggtggcgagc ggggccgggg cggcctggtg ctcatgcacc
    16801 ggctgctcca gcacgccgtc cggtcccgga tgaccgagga ggaactcgac gaggcgcgcc
    16861 gccaggtcca cctggtgctc gccgccgccc ggcccgaggg cgaggtggac gaccccgacg
    16921 gctggccccg gttccgggtc atctggccgc acctggaggc gtcgaaggcg ccgctgagcc
    16981 accgggtgga ggtgcgggcc ctgatgatcg accgggtccg ctacctccag ttgcgcggcg
    17041 acctggagac cggccggcgg ctcggcgagg aggtcgcgca gacctgggag cagatgctgg
    17101 ccgaggagac cgacgcacgg gcgcgcgacg acctgcgccg gcagttgctg cacctccagt
    17161 tcaacctcgc aaacatcctc gccttcctcg ggcagttcca gcagtcccgg gcgctggacg
    17221 aggaggtcct cgcggcccag cgggaactgc tcggcgagga ccacccgcac acgctgatga
    17281 ccgccggcgg gctggcccgc gacctgcgcg gcatgggcaa gtacaacgag gcgctgcgcc
    17341 tggacgagat cacgttcaac gcgtggaaac ggaacttcac cgaggagcac ccacgtacgc
    17401 tcgtcgcgct gaacaacctg gccaccaccc agcgcctgat gggtgacttc cgggaggccc
    17461 gcaagaacga cgagatggtg ctggccgggc gccgcgcgat cctcggggag gaccacccgg
    17521 acacgctcgc ctcgtccgcg tacgtgggca tcgacatgcg cgacgccggc gactacgagc
    17581 agtccatcgc ccggctccgc ggcgtccacc gggacctgct gcgcacggcc ggggcggaac
    17641 acctgatgac cctgcgcgcg cagaccaacc tggcggtgtc gctgcgctcg gccgggcacg
    17701 cggtcgaggc gggcaagctc ctcgaagccg cgtacgagct gctgaacgag cggttcgggc
    17761 cggacaaccc ggagacgctc acctgccggc tgagcctgtc cgtcaacctg ctcagcgtcg
    17821 acctgttcca gcgcgccagc cgcgaactga ccgaggtgca ccgcgtctac cagcagaacc
    17881 tcggcccgga gcacccgctg acgctggtct gcatggtcaa cctcgccatg gtcgcccgcc
    17941 gcgccgggga cttcgccgag gcccggcaac tcgccggccg gtccgccgac gcgctcgccg
    18001 acgtgctggg cagcgatcac ccgtatcccc tctccgggtg gatgaaccag ggcatctgca
    18061 tcgccgagca gccggacccg ccggagggcc gggaggcggc ggacctggag gcgctggggc
    18121 tgttgcggcg cgccgacgac ggcctgaccc ggatgctcgg ccgcgaccac ccgaacacgc
    18181 tgcgctcccg ggcgaatctg gtggtgatgc aggagcggat ggagagcgga cggcgggcgg
    18241 agctggaggc ggtcacccgc gaactggcct accggctggg cgagaaccac ccggcggtcg
    18301 aggccgtccg ggagaaccag ttgcagcggc gcatcatcga cccgcatccg atctgacagc
    18361 ggcgcgctcc accgggccgg ccagccaggc gaggatctcc ggcagcacct cgaccgcgcc
    18421 gaagtgcgcg ctacgcggct gcacgtgcag ttgcgcgccg gggatctgct cggccagcca
    18481 gcgggtgtgg ctggccgggg cgaagttgtc gtccgcgccg tgccacagcc gtaccggcat
    18541 ccggatgtcc gccagcgtga cgccccagtc ggcgcgcagc gcgaggacgt cgtcgatcca
    18601 gccgtgcggc ccctggcgca gcgcctcggc gtaggcgtcg gtcagctgcc ggcggatcgg
    18661 caccccggcc accacccggc ggtcggccgc ggtcatctgc tcgaccagca gcgcgagcag
    18721 cgagcccggg tcgtccatcg tgcgctcggc ccgcagccgc aactgctcgg cgagcaccgg
    18781 cacggcgcgc tcggcggcgc cgtagtcccg cacgttggcg tcggtcatgc cgccgaacca
    18841 gtccagcccg gccgcccccg ccggggcgag gccgaccaga acggccgtgc gccgtacccg
    18901 ctccggcagc agcgcggcgc aggccagggc gtgcgggccg ccgccggatc ggccgaccac
    18961 cgagaacccg tccaggccga ggtcgtcggc gatggccgcg acgtcggcgg cggcgtcggc
    19021 gatccggcgg ccgggcaggc ggctggagcc gccgtagccc ggccggtcgt aggagatcag
    19081 gcgtacgccg aggcggtgta gcacgatcga gcgtggtcgc gggccgttac ggctgcccgg
    19141 cgtgccgtgc atcaggaaca ccggccagcc gtgtttcgcc ccggcgatgt cgaccgccag
    19201 gttcctcctt cccgtccgga cgatgtgctc acgatgcggg ggcgagtgtg ccaatcgggg
    19261 cctccgaacg ggtggtggcg gtgcgggtgg cgcggtcaga ccgcctcggc ggccgggatc
    19321 tggtcggtct gctcgggctg gtcggtccgg tcgggctggt cggtcgctgc gaggacgcgc
    19381 agcgtgtgga gggcggacgc cagcgagacc tcggccggcg cccggtcgtg cgcccgcagg
    19441 tagtccacga gcagccggca caggctcgcc tcgtcgagga actcgtccgg cagccggtgg
    19501 gcgagcagct cggccatcgt ccggggcggg atcttccgcc aggccaggtc gccgtactcg
    19561 gtcaacgcca tgagcagcca cagcgcggtg cggttgtcga cccgcgcggc cgcgaactgc
    19621 tcggccatct cggccgacac cacgccgtcc tccagcggca gctccgcgag ccgcccctcg
    19681 atgtcggcga gcaccgcccg cacccggggc acgtaccgcc ggggcagccg gtcgagcccg
    19741 tgccgcagga tgagcgcgtg cagcaccgcg tggtcgtcgg tcgtgccgag cgagtcgacc
    19801 agctccggga actcgtcgat caggtacggg cacgagatga tcagctccgg tggcgctgtc
    19861 ggtgagctgg gcaaccggct cagcgccacc cgggtcagcc cgcacaccac ctcgcggggc
    19921 aactgcgcgc cgtcctcggc gaggcattcc agcaggaccg tggcactggt gctggacacc
    19981 gcctccggga actcgacggc gcgcgcccac agccgccggt agctgcgctc gtcgtacagg
    20041 atcagctggt gcagtgacgg caccggccag cggcgggtgg ccagctccac cagatccgcg
    20101 tggaaccggc ccgcctcgaa gctggtcggc gcctggccgc gccacgtccg cgcgccggcc
    20161 tgcaactggc tgtaggtggt gacgtcgccg agcagccggg cctcctcggc cgccacgttc
    20221 accttctccc cccggctctc acgccgccgc tcggcgacga tccggccgtc ggcgtcgcgg
    20281 cgcagccagc tgatcatcgc gagctggccc ttctcgtcca gacccgcccg ccacagccgc
    20341 accgtggaca tccaggtctc gtcgtccatc aggtcgctgt gccgcacccc gtccggtgac
    20401 acgagcgcgg ccagcgcgat caggttcgcg gtgtacgcgg cgagcagccg caccgggtcg
    20461 tacggcgcgg gccggtagcc gtccaccccg gccaggttgg tccgctgccg ggcctcggcc
    20521 agcaggccgg cgaccgtctc cacgatcgag tcccgctccc ccgggtggcg ggaggcgagt
    20581 tcccgcgcga agccgaccac cgcctcccgc ttgaccagcg gttggtgcga gagcagcgcc
    20641 cggaactggc cggtgtccag ctgatagccg aacccggccg ggctgcgggt gtgccgccgc
    20701 agctcggcca ggctccgcag cgccccgatg acgtactcgg cgatcaggaa gtcgccgatg
    20761 gtggcgtgca ggaactcgta cgtgcgccgg gcgtcctcgc cctgcacgtc gtccgggccg
    20821 tacaccacga agaaggcggc ggtgaccagt tgctccgggc cgagcacgtc gccgagttcg
    20881 aaccgggagc cgtcgccggc cccgggcccg aaacagccga ggtcggcgcg gagcgcggcg
    20941 cggttcacga gttcccggtt gcggttgaac atggcgaacg cggtgatcgc caggtcgcgc
    21001 cgcagttggt gttcgcgggc ctcccgttcg tggtgcggga gggcggtcgg cgccttctcg
    21061 ctcacctgcc gtctgatgaa cgcggtgagc aggccggtga acaggtcgga cggggagatg
    21121 gcggcgcccg gacggcggtc ggcccagtgc tcgttgtagt agatggcgag cagcgtgagc
    21181 agcagcggct ggcgggccag ctcgccgtgc gacagcagct cgcgggcggc gagccggcgg
    21241 tatccgggcc ggtcctcgtt tgccgcgttg acggcggcca gccaggccgt cacctgggcg
    21301 tcggtcaggt cctccagccg caccagcacg gtgccctgcg gcacgctggc gcggtccatc
    21361 accaggatcc gggacgtgat gatcgggatg acggagtagc ccaggtccca ctgggcctcc
    21421 tggaactcgg ccacccggtc gatgtactga gagtgggcgg tgccggtgac ctggacgagc
    21481 tcgtcgaacc cgtcgaagat caccacgact gtggtgttct cggtggcccg ccgcaggtcc
    21541 gcccagcgga tgcgctcgtc catcacctgc tcgatcgcgg cctcgatctg ttccgtcggc
    21601 gacgtgtccc cggacatccg gcgcagtggc accactatcg cggtgaaccg gctcgccggc
    21661 agccgggccg cgatgacccg ggtcagcaac gtcttgccgg cgcccggctg gccgaggagc
    21721 agcagcggac ggtgcaggct cgccggatcg gtcaggtact cggagaggaa cccgaccagg
    21781 tcgccccggc gcggctggtc gtcccaccag cgctcccgct ccggcgacgt gtgcttgccg
    21841 tactcggcgg cccggaagtc cgggctgatg aatccctcct ccacagtggg caggcgcagg
    21901 tggaagtcga cgtccttgat ccgtagcagc ggctgccgga acaccgcggc cagcgagccg
    21961 gtgagccggt cgagggactc acgcagcagg tcggggcggt cggccgggac cgggccggac
    22021 agctcggcga gattgcggta cagctgcgcc agcgcgtcca gccgggccga gacctcggtg
    22081 gtcaggttcc gattgtcgat caggttgtgc tcgatcgcct gccggagcat ccggaacccg
    22141 aactcgggga ggtccgcggc gaggcggtcg aagcggtcct cgtagtgcca catggcccgg
    22201 cccaccaccc gggaccgcag cgacgtgagg tcgagcccgc gccgcaccga cggccaggcg
    22261 gcgaggccct cgcagaacgc gatggtggcg tcgtagagct tgac
//
