LOCUS       NZ_CP030865            21911 bp    DNA     circular CON 14-AUG-2024
DEFINITION  Micromonospora sp. B006 chromosome, complete genome.
ACCESSION   NZ_CP030865
VERSION     NZ_CP030865.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora sp. B006
  ORGANISM  Micromonospora sp. B006
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 7040153)
  AUTHORS   Braesel,J., Crnkovic,C.M., Kunstman,K.J., Green,S.J.,
            Maienschein-Cline,M., Orjala,J., Murphy,B.T. and Eustaquio,A.S.
  TITLE     Complete Genome of Micromonospora sp. Strain B006 Reveals
            Biosynthetic Potential of a Lake Michigan Actinomycete
  JOURNAL   J Nat Prod 81 (9), 2057-2068 (2018)
   PUBMED   30110167
REFERENCE   2  (bases 1 to 7040153)
  AUTHORS   Braesel,J., Crnkovic,C.M., Kunstman,K.J., Green,S.J.,
            Maienschein-Cline,M., Orjala,J., Murphy,B.T. and Eustaquio,A.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2018) Medicinal Chemistry and Pharmacognosy,
            University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL
            60607, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 77.6x
            Sequencing Technology :: Illumina; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003408515.1-RS_2024_08_14
            Annotation Date                   :: 08/14/2024 03:31:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,342
            CDSs (total)                      :: 6,278
            Genes (coding)                    :: 6,199
            CDSs (with protein)               :: 6,199
            Genes (RNA)                       :: 64
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 20 of 79
            Pseudo Genes (incomplete)         :: 62 of 79
            Pseudo Genes (internal stop)      :: 6 of 79
            Pseudo Genes (multiple problems)  :: 7 of 79
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:07:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6641919
            Orig. end                         :: 6663830
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21911
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /product="RiPP-like"
                     /region_number="24"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..21911
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="interleaved"
                     /product="RRE-containing"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..21911
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11911](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11911)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(107..121)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            complement(540..942)
                     /locus_tag="MicB006_RS29755"
                     /pseudo=""
     CDS             complement(540..942)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286004.1"
                     /locus_tag="MicB006_RS29755"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTPQFDLVGAVVTDMARTLDFYRRLGLPIPAGAETEGHVEVTLPN
                     GVRLAWDTVEMIRSFHPDFDPSGGNNRMSLAFRCADPAEVDRWYAELTAAGHHGELPPW
                     DAFWGQRYAVPARPGRQRRGPVRPAAGGRL"
     gene            1123..1281
                     /locus_tag="MicB006_RS32120"
                     /old_locus_tag="MicB006_5947"
     CDS             1123..1281
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787270.1"
                     /locus_tag="MicB006_RS32120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5947"
                     /product="hypothetical protein"
                     /protein_id="WP_184685639.1"
                     /transl_table=11
                     /translation="MNHLAYLDAGSGSLIVQAVVGGVAGVAVAAKLYWRRLVSRFRRQP
                     SDQGPAA"
     gene            1278..2693
                     /locus_tag="MicB006_RS29760"
                     /old_locus_tag="MicB006_5948"
     CDS             1278..2693
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286006.1"
                     /locus_tag="MicB006_RS29760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5948"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_116510593.1"
                     /transl_table=11
                     /translation="MTVPDTGVRVEPGSFRDPGNRVFHRGEEVLRGLDERSARDWRALS
                     VTDFFRRAAEQGQIVATEELTPVPVDTSWAAVLRHERIPFVSHPYEWSSAMLRDAALLH
                     LDVLRAALEAGFTTKDGSAYNVQWRGARPVFIDVGSFEALRDGEPWAGYRQFCQTLLYP
                     LLIQAHLGLDFQPFLRARVDGVEADQMRRLFGGARRWRAGVPTHVHLHGAMQARNSAAS
                     TTDVRAQLRAAGFSRELALATVRGLTKLVRRLDHRPGGSHWSDYQRTCAYSVPDRQAKE
                     EFVDRAVAATGGGSALDLGANDGRYARIAARHAAHVVAVEQDPAVVDTLYRALRDEGET
                     RILPLVMDLADPSPGGGWRGVERAAFADRARADVVLALAVVHHLAIGRNVPLPEVLNQL
                     TALTATGGSLVVEFVHPDDPMARRLLANKPDGLFPNYRRDAFEALLARRGRVVARTKLP
                     SGTRTLYQVVVGG"
     gene            2686..4749
                     /locus_tag="MicB006_RS29765"
                     /old_locus_tag="MicB006_5949"
     CDS             2686..4749
                     /GO_function="GO:0008484 - sulfuric ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477023.1"
                     /locus_tag="MicB006_RS29765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5949"
                     /product="sulfatase-like hydrolase/transferase"
                     /protein_id="WP_116510595.1"
                     /transl_table=11
                     /translation="MAERTLAPPRDHAAGPDRRERPPWWRSEAARLAEVTALVGLVVTQ
                     PLLDVLGRSPDFFLFHRASRGDVLLLVALIALAPTALFALLGAFALLGALAVPAGRLVR
                     AAVHTAFVGLLLAALAVQVGRHVTPLRGVPLLVVAGVAGAAGAAAHRRWRAPRRVLRVA
                     AAGPLVFVGLFLFASPASAVVLPRGEGGAAGVAGAGAHPPVVMIVLDELPLVSLLGPDG
                     RIDAARYPNFAALAAGSTWYRNATGVSGWTPYALPAMLTGRYPERGVAPHYSQYPDNLF
                     TALGGLYRVKAEESITRLCPPSRCEQATTPEQGLGVLVRESGKLLGRIAAPVDSRVDPE
                     DSYRERTAAEAGLDAAEPVPDDPKFRWDTLDDNQPARFTSFLAGLRPDPRPTLHFLHLL
                     MPHSPWAYLPSGAHYAAPEDLPNDGAGWVDLARARHLAQLGYTDRLIGETLRTLRATGL
                     YDQALVVVTADHGVSFRRDWQGRGMDAIDHAANEVAWVPMFVKKPGQRAGRVDDRNWEH
                     VDLLPTIADETHMRVPWQMDGRSAAAAPRERSDKHFYDHPGQPVTITGGVPAPLPPVPV
                     DPLVGTRVPDMPVGGSATVANRDAFDAVDPARGGLPALVWGTVPDDVPDGTRLAVAVNG
                     TVGAVVPVVPPDAGGRRFAAFLPDDRLFAAGPNRLDLYRVGDDGSLRRLTLS"
     protocluster    3055..15004
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[8054:10004](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(8055..10004)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     misc_feature    complement(4770..4784)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.51"
                     /tool="antismash"
     misc_feature    4813..4831
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.96"
                     /tool="antismash"
     gene            4926..6209
                     /locus_tag="MicB006_RS29770"
                     /old_locus_tag="MicB006_5950"
     CDS             4926..6209
                     /EC_number="2.3.3.16"
                     /GO_function="GO:0046912 - acyltransferase activity, acyl
                     groups converted into alkyl on transfer [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018252835.1"
                     /locus_tag="MicB006_RS29770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5950"
                     /product="citrate synthase"
                     /protein_id="WP_116510596.1"
                     /transl_table=11
                     /translation="MTEVKLDHPGGQLSMPVQSAVEGPAGIGVSKLLKETGMTTYDPGF
                     VNTASCSSAITYIDGDAGILRYRGYPIDQLAEKSSFLEVSYLLIYGELPTQTQLTEFSE
                     RIRRHSLLHEEMRRFFDGFPRDAHPMAVLSSAVSAISTFYQDSLDPFDSEHVEMSTVRL
                     MAKVPTIASYAYKKSIGQPLLYPDNSLGYVENFLRMTFGVPAEPYEVDPVVARVLDMLF
                     VLHADHEQNCSTSTVRLVGSSNANLFASVSAGVNALFGPLHGGANQAVLEMLQKIQADG
                     GDVRSFVRKVKDKQDGVKLMGFGHRVYKNYDPRAAIVKKAAQDVLGRMSKPDPLLDLAV
                     QLEEIALADDFFVSRRLYPNVDFYTGLIYKAMGFPTKMFTVLFALGRLPGWIAQWREMI
                     NDPETKIGRPRQIYTGAVERDYVPADKR"
     gene            complement(6388..7785)
                     /locus_tag="MicB006_RS29775"
                     /old_locus_tag="MicB006_5951"
     CDS             complement(6388..7785)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013477022.1"
                     /locus_tag="MicB006_RS29775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5951"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_116510597.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.5e-39,
                     bitscore: 132.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLRVGAQPATATDRLHRPTLTSRPAPPSPAGAAPRTRRILMLS
                     WEYPPVLVGGLGRHVHALSVALAAAGHEVTVVTRHAEGAPLEEYADGVRIVRAAEDPVT
                     FPLATGSLLAWTMAFNHTLTRAALRAASSGAYDVIHAHDWLVAHTAMTLREHLDVPLVS
                     TIHATEAGRHQGWLPEEMNRTIHGVEHWLAGESGRVIVCSGYMRDEVGALFGVDAARVD
                     VVPNGVEPHRWRVPASAVAAARARFAADGPLVTFAGRLVYEKGVQHLLAGLPRLRDRHP
                     GLRAVIVGDGPYRAELEAEVHRLGLGATVSMPGFLGGTDLPAVMAASDCFAVPSIYEPF
                     GMVALEGAAAGAPLAVARTGGLAEIVEPGVTGMTFAPHDPDGLAEAVHALLSDRDRARA
                     LARRARAMVHERYGWAAIASRTAAAYVAAIAGDPAFTAARAQHRMAHGHPTPRVPEGNL
                     LTAAGLR"
     gene            complement(7846..7971)
                     /locus_tag="MicB006_RS32650"
     CDS             complement(7846..7971)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS32650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255419514.1"
                     /transl_table=11
                     /translation="MTGRFRFPIDVSTLPVARDRYPAQAVVGELVPTPGRPSGRS"
     gene            complement(8055..10004)
                     /locus_tag="MicB006_RS29780"
                     /old_locus_tag="MicB006_5952"
     CDS             complement(8055..10004)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="MicB006_RS29780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5952"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_152037916.1"
                     /sec_met_domain="YcaO (E-value: 1.2e-69, bitscore: 234.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1e-87, bitscore:
                     292.9, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVTTTPAVPASPDVTPRHGLRILGAGALRRAVEQALGAAPVAD
                     VDVFVVDGPPEDVEVAARAAADAGRAFLPVYTTPRGVRIGPFVRPGRPGCHHCLQVRQR
                     RARTTGTPHRSALWQGLYDGSVQPARPVLGPPVRATVAALVADELRRVAQGGDGRCAEA
                     VLEVITASMAVKRHRFVPEPGCPVCGPLPDDGPAAGTFTLTSRPKRAPGDYRARSLPDE
                     HLALLAALHDEETGLLSSITVHHNHPMVLAGAIGGPLCCGELAGYGRTFTYPASVAVAV
                     AEALERLGGNVPRARRTVTRASFRELGPRRAVEPTEFGLPPAPPDDHAVAYDPDRPVEW
                     VYAYSFRRDGPVLVPETFAYYGSHGTGFGPECSNGCALGANLEEAILHGIFEVAERDAF
                     LSTWYARLPVPRVDPMTSADPMTRVLVDWIQRTTGSRLDVFDITMPEGVPAVWLMLVDD
                     EVRPGRPRAFCGAGAHLDPERALWSALVELASVAEATREMVAEDTTAPGLVADPDLVRA
                     MEDHLLAAASPEAWPRFAFLYERDEILSMAEAFPPAARYRPAMDLLDDLRHVTGRYLDE
                     GLDVVVVDQTAREQAAVGLTSVKVLIPGLLPMTFGHRNRRVDLPRLRDLPVRLGHRAEP
                     LTPEEINPHPHPFP"
     gene            complement(10001..11911)
                     /locus_tag="MicB006_RS31910"
                     /old_locus_tag="MicB006_5953"
     CDS             complement(10001..11911)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS31910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MicB006_5953"
                     /product="hypothetical protein"
                     /protein_id="WP_161565978.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 1.8e-19,
                     bitscore: 68.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     9.6e-16, bitscore: 56.0, seeds: 5, tool:
                     rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVKLRDDLMYVPVDDGVYLETGLASTHLAGASAYGLVQRLAPHL
                     DGTRTVQELTDGLPAAQRQLVTDLVGMLVRRGIARDLDSEPPHTLRDWELACYRDSIAF
                     AEHVTDAPLSRFEAFRNGRVLLVGAGAGMLALVQTLFELGLRTASLVETAETGTERDGF
                     RRIVQRRRAEDPTTGLTLLDAAAALDTDEGLAGLLAGYDAVLHCAARPMAGRATRLNRA
                     ARAIGVPVLHAVPGGEEAWIGPTGGGVTGGCWECGLLSRQGAGLPPGDGDEPDTTSEWL
                     SAPVCGLIGAALGFAYLRHRMGAETTATNRMTRVDLETAVTSEHLLDVHPRCRSCRPPV
                     AYADLAAHVDAMAARTPVDVEEFVARMPFLVDARLGPLLAIDTGAHSQISVSCVEATVV
                     DLAGGAPRLLTAVGGSREQALLRAATAALETLAARACADDAATVWWDAGRGALVDAQPD
                     GVVVAGGHTWAEARGRAILKLRRAAATPPEVTTADGGPPGGWLDRTRWPEPTRVMAHEL
                     ALLGHEPRAWHDGSSTPTVFVAAGDRWVAHSCATDTDTALANAMQAAVAVLTGRRPDGA
                     EIGPDVGGGDWDTALPLLLRELARDGRSLLVRPADSLPGAQRVMPFMIRAAWSPRAGSR
                     A"
     aSDomain        complement(11639..11908)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MicB006_RS31910_Heterocycloanthracin_
                     C_RRE.1"
                     /evalue="4.30E-18"
                     /identifier="RREFam011.1"
                     /label="MicB006_RS31910"
                     /locus_tag="MicB006_RS31910"
                     /protein_end="91"
                     /protein_start="1"
                     /score="56.0"
                     /tool="antismash"
                     /translation="RVKLRDDLMYVPVDDGVYLETGLASTHLAGASAYGLVQRLAPHLD
                     GTRTVQELTDGLPAAQRQLVTDLVGMLVRRGIARDLDSEPPHTLR"
     aSDomain        complement(11678..11911)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MicB006_RS31910_Thiopeptide_F_RRE.1"
                     /evalue="8.20E-22"
                     /identifier="RREFam004.1"
                     /label="MicB006_RS31910"
                     /locus_tag="MicB006_RS31910"
                     /protein_end="78"
                     /protein_start="0"
                     /score="68.0"
                     /tool="antismash"
                     /translation="MRVKLRDDLMYVPVDDGVYLETGLASTHLAGASAYGLVQRLAPHL
                     DGTRTVQELTDGLPAAQRQLVTDLVGMLVRRGI"
     gene            complement(11908..12789)
                     /locus_tag="MicB006_RS29790"
                     /old_locus_tag="MicB006_5954"
     CDS             complement(11908..12789)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (14-278). E-value: 3.7e-28. Score:
                     91.0. Matches aSDomain:
                     nrpspksdomains_MicB006_RS29790_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1046: Dioxygenase TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014698.4"
                     /locus_tag="MicB006_RS29790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5954"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_116510600.1"
                     /sec_met_domain="TauD (E-value: 3.9e-26, bitscore: 91.0,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEQDVPALVGTPTPDTVLAAVAEHGAVLLRGGWRHEDYVALGDA
                     LMTASPYQGGFHDERDVIGGDPTTTTVTRGTQGMPLHREASYAPGAPDLLMFRCERPAA
                     DGGATTLCDGLALLAALPAAVRAACEELTLRWESALPTPVWQRMCGTTDPAAAERMLRQ
                     WEPYLRPWESIHIDVDEDAMTVGFGTRCTPPTLFEGVPAFCNSLFISRPQPGEYHDRRL
                     RVRSGTGAPVPEDLVATAADVAARLTVAVPWRSGDVLVVDNSRYLHGRQAFTDAGRAVA
                     VRMGHLRKEVAA"
     aSDomain        complement(11956..12747)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MicB006_RS29790_TauD.1"
                     /evalue="3.70E-28"
                     /label="MicB006_RS29790_TauD.1"
                     /locus_tag="MicB006_RS29790"
                     /protein_end="278"
                     /protein_start="14"
                     /score="91.0"
                     /tool="antismash"
                     /translation="PDTVLAAVAEHGAVLLRGGWRHEDYVALGDALMTASPYQGGFHDE
                     RDVIGGDPTTTTVTRGTQGMPLHREASYAPGAPDLLMFRCERPAADGGATTLCDGLALL
                     AALPAAVRAACEELTLRWESALPTPVWQRMCGTTDPAAAERMLRQWEPYLRPWESIHID
                     VDEDAMTVGFGTRCTPPTLFEGVPAFCNSLFISRPQPGEYHDRRLRVRSGTGAPVPEDL
                     VATAADVAARLTVAVPWRSGDVLVVDNSRYLHGRQAFTDAGR"
     gene            complement(12782..14395)
                     /locus_tag="MicB006_RS29795"
                     /old_locus_tag="MicB006_5955"
     CDS             complement(12782..14395)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS29795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MicB006_5955"
                     /product="hypothetical protein"
                     /protein_id="WP_116510601.1"
                     /transl_table=11
                     /translation="MGASRAGVAGRYLAAVQADTGQPTAYLPPRGKRYPGVARRPLRWP
                     GPGSVPLGDGCLDRLSAMLLGYAPRRAETITLAGLSALTGAPLDTPTPSRLLPGWHTLR
                     RSVPSGGAFHPNEIYLAWAGSPDLAAGVYHYDPPHHCLELLRPGSPAARLDRLLGVAAA
                     PRHALLLTHRPWKNTSKYGAFGYRLGIVDSGVLLAQMLTSPVDATPRLDLDPVLAGELL
                     GLDAELEATYAVIEFPADADVPWTPPASGGPPPATGLDHDRLGHDAAHPSAVALHRATY
                     DRDAAAQPPSADRLPAGCLPADPVPADGSPAQRLPADRLPMGPVAGRALDLPPARPLDL
                     VAVAARRASAANLGPGLTAGQVADILACAAGRAGSPALAALARQPLYPEIWCLARTVDG
                     IPADAYRYRPYHHRLVPTGPPGAADDTAAYPHRVDRRMVTRGATLYLVHAGSRPVDQLS
                     PASFHRLHLLAGVALHLAGLAAAATGAASRALGGLTADAVAARLGLPDGASPLTQLLVG
                     TPAPRPGVLAAHLTEGNPHG"
     gene            complement(14397..15185)
                     /locus_tag="MicB006_RS29800"
                     /old_locus_tag="MicB006_5956"
     CDS             complement(14397..15185)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014690183.1"
                     /locus_tag="MicB006_RS29800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5956"
                     /product="ABC transporter permease"
                     /protein_id="WP_225980572.1"
                     /transl_table=11
                     /translation="MMHEARIYRRLLGAHLRAVLEYRADALLTIGATLLGQLAGLVFVV
                     MVFRQVTALGGWTRWEVLYVCAMVMLAEGVGSLLFEGTWHLGGLVNLGLLDYLLVRPYP
                     VVLQVTGNAVGFNGLGNVGFGAALLGAAAVHLDLAWTPLTVLWAALLLVSGVLVKLAVN
                     LATNAVVFWLLSPSSSLAASVHTLGDLARYPLTLYGTGLRSLLTLVPVAFVGYFPTAAL
                     LDKGASTTAGALTPVVAAACAAGAWAVFRAGLRRYESAGS"
     gene            complement(15193..15987)
                     /locus_tag="MicB006_RS29805"
                     /old_locus_tag="MicB006_5957"
     CDS             complement(15193..15987)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017946.4"
                     /locus_tag="MicB006_RS29805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5957"
                     /product="ABC-2 family transporter protein"
                     /protein_id="WP_116510602.1"
                     /transl_table=11
                     /translation="MRAYLTLARMSWSTLLIYRGEFLLQLTGVVVQTVALFAVWQAVFA
                     GAAGGEVGGLSWEQMKGYLVVAFLTGALLSSFTDAQIAGPVLHGTVALDLVRPIDYQLS
                     RFALSLGYVVGEVLTVAVMAATLVSAFGGAALPAAGQAGLFLLSLLAVVPLKFGLVYLV
                     GLLCFWTGNFHGLSLSRVAITNILSGALVPIALFPGWLQVVCQLSPFPGIVSTPALIYL
                     GQIRGAEAVTLIGVQLLWVVVLWGAARLLWSAGVRRLTAHGG"
     gene            complement(15984..16991)
                     /locus_tag="MicB006_RS29810"
                     /old_locus_tag="MicB006_5958"
     CDS             complement(15984..16991)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072249.1"
                     /locus_tag="MicB006_RS29810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5958"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_116510604.1"
                     /transl_table=11
                     /translation="MPVIEASGLTKRFRIADKQPGLRGSLRHLVRPRHVEHVAVDGVDL
                     SISTGEAVAYVGPNGAGKSTTVKLLTGILHPTAGRVRVCGLDPHRDRHANARNIGVLFG
                     QRSQLWWDLQVRDSLALLRDIHRIPRARYAARLEEFDALLGLGRLLPVVARQLSLGQRM
                     RADLAAALLHSPPVVFLDEPTIGLDIVARQAVRDFLRAQRASGTTVLMTTHDIGDIEQV
                     CRRLVIIDGGRIIFDGSIDAVRRLVADQRTVHLTLGADWHGDLDADLPGVRLVHDGSAR
                     QIAVTFDHGAYGAGEIVSVVARQAPVVDIRIDEPSIEDVVRRAYAGELSPSVPA"
     misc_feature    16981..16995
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            complement(17010..18362)
                     /locus_tag="MicB006_RS29815"
                     /old_locus_tag="MicB006_5959"
     CDS             complement(17010..18362)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025025.4"
                     /locus_tag="MicB006_RS29815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5959"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_116510605.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.3e-23,
                     bitscore: 80.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVEPGRAVELSVVIPTHADAPCLELTLRSLRRQTLDPDRFEVIV
                     VRDGGDGSQYSGIADAGKGLRLHFVERPERGGRAAARNEAARRATAPLLLFLDADSYAT
                     PDLLRRHLDHHRDPSAPAVLMGRRDETGIEHVHAALADQPTMPVPRLRGRGGGDMRFGT
                     EEGPSGDDWLLAGWLFCFTHNASVRRDVFEAVGGFDEGFGLRWGLEDMELFYRVHAHLG
                     VLNHNFAYDDLAAVYHLPHHRNVIQNWNDFMDNLDRVALKYPVVEWEFAGPVDVARAAE
                     RVVHYRRAMDDCVRRSWCRIGPAVQRLAGRLPGDRVLWVGTGSAEAGLPDGALTYDYGA
                     PAGPANFHLVGIRPPVAADSLDAVVSVDFWRYLYWEDLCQFVNVAGGLADEVHLVSTGA
                     ELSARFDPDPASLGYLGRVMGAAFETTLTEVDGLGSVLRLRPHHRAAVAAG"
     misc_feature    18342..18355
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    complement(18452..18467)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.47"
                     /tool="antismash"
     gene            complement(18457..18675)
                     /locus_tag="MicB006_RS29820"
                     /old_locus_tag="MicB006_5960"
     CDS             complement(18457..18675)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS29820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MicB006_5960"
                     /product="hypothetical protein"
                     /protein_id="WP_073829738.1"
                     /transl_table=11
                     /translation="MGESRNASIDLSDLDTTAVSWSGAGDEASAGLYAMPTAGGITLTD
                     PSAMGKGSCGGAACQGRPIQWCCVNCH"
     gene            19220..21340
                     /gene="glgX"
                     /locus_tag="MicB006_RS29825"
                     /old_locus_tag="MicB006_5961"
     CDS             19220..21340
                     /EC_number="3.2.1.196"
                     /GO_function="GO:0004133 - glycogen debranching enzyme
                     activity [Evidence IEA]"
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005980 - glycogen catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glgX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788443.1"
                     /locus_tag="MicB006_RS29825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5961"
                     /product="glycogen debranching protein GlgX"
                     /protein_id="WP_116510607.1"
                     /sec_met_domain="CBM_48 (E-value: 1.6e-19, bitscore: 68.5,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 2.7e-15, bitscore:
                     55.3, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVWPGESYPLGATYDGMGTNFAIFSEVAEKVELCLFDEWDIGTE
                     RRVELREVDAYVWHAYIGGVEPGQRYGYRVHGPWNPAEGLRCNPHKLLLDPYAKAVDGE
                     VTWHPSVYDYEVGGDPDRMNTEDSAPYMPKSVVVNPYFDWGNDRPPRTPYHHSVIYEAH
                     VRGLTMRHPGIPEELRGTYAAIASPVMIEHFKRLGVTAVELMPVHEFVHDHRLADLGLR
                     NYWGYNSIGFFAPHHGYSALGRLGQQVQEFRGMVKALHAAGIEVILDVVYNHTAEGNHL
                     GPSLSFKGIDTPSYYRLSEEDRRYFVDYTGTGNSLNVRSPHSLQLIMDSLRYWVTEMHV
                     DGFRFDLAATLAREFYEVDRLSTFFEVVQQDPVVGRVKLIAEPWDVGPGGYQVGNFPPQ
                     WTEWNGKYRDTVRDFWRGEPATLAEFASRISGSADLYQDDGRRPFHSINFVTCHDGFTL
                     TDLVSYNDKHNDANGEDNRDGESHNRSWNCGVEGETDDPGVRALRARQRRNFLATLMLS
                     QGVPMLGHGDELGRTQRGNNNAYCQDSELAWVDWDRADTELLDFVRRLTEFRNRHQVFR
                     RRRFFTGLPVGGRAAGSGLPDLAWYTPDGREMTGEDWGNDFGRSVALFVNGDGIGERGQ
                     YGQRHRDDSFLLLFNAHDAPLDFTLPGEEFGSRWELVISTAEPDPEKTTLVEAGGTVCV
                     PDRSLLVLERTA"
ORIGIN
        1 cgcctgccgc cggggaccgg cccggccgtg ttcggcgtgc ccgccgagga gctgcgggac
       61 cgccgcgtac cgctcgccga cctgtggggc cgcgccgccg ccgaggtggc cgagcgggtc
      121 gagaccgcgc tgtccgcgcc gaccggcagc gacgggactg acgccgccgc tgccgtgctg
      181 acgcgggtgg cccgggatcg gctgcgcgag gccggcggcc ccgacccgct cggcgcgcgg
      241 atcgccggac gcctgtccgc cggggccact gtcgccgcga ccgccgccga ggtcggcctc
      301 ggcgcgcgtg ctctgcaccg gcgcagccgg accctgttcg ggtacggccc gaagacgctg
      361 gcccgcatcc tgcggatgcg ccgcgcgctg gacctggccc gtagcggcgc gccgctcgcc
      421 gaggtggcgg tgcgcagcgg gtacgccgat caggcccacc tcacccgcga ggtgcgggag
      481 ctggccgggg tgcccccgac gcggctgctc accccggcca ccgcctgacc ggcctccggt
      541 cagtcgcccg ccggcagcgg ggcgaacagg tccacgccgt tgccgtccgg gtcgtgcagg
      601 gaccgcgtac cgctggcccc agaacgcgtc ccacgggggc agctcaccgt ggtggccggc
      661 ggcggtcagc tcggcgtacc agcggtccac ctcggccggg tcggcgcacc ggaaggccag
      721 gctcatccgg ttgttgccgc cggacgggtc gaagtcgggg tggaagctgc ggatcatctc
      781 gaccgtgtcc caggccagcc gtacgccgtt cggcagcgtg acctccacgt gcccttccgt
      841 ctcggcgccg gccgggatcg gcagccccag ccgccggtag aagtcgagcg tgcgtgccat
      901 gtcggtgacc acggccccga ccagatcgaa ctgcggtgtc atgccgccac ggtaggcgcg
      961 agggggaccg cccgtcttga acggatcgga cgggggacga gtggccggtg tggccgcgcg
     1021 tgcggcgccc gaggcgttac ggtggggaac aagtccggct ttgagcatta aagctcgcat
     1081 accgggcgcg caccgacgac cggcgacgga aggaaagcag ccgtgaacca cctggcctac
     1141 ctggacgcgg gatcgggcag tctcatcgtg caggcggtgg tcggcggcgt ggccggagtg
     1201 gccgtggccg ccaagctcta ctggcggcgc ctggtgtccc ggttccgccg ccagcccagc
     1261 gaccagggcc ccgcggcgtg acggtccccg acaccggcgt ccgcgtcgaa cccggctcct
     1321 tccgcgaccc cggcaaccgg gtgttccacc ggggcgaaga ggtgctgcgc gggcttgacg
     1381 agcgttccgc ccgcgactgg cgggcgctgt ccgtcaccga cttcttccgc cgcgcggccg
     1441 agcaggggca gatcgtcgcc accgaggagc tgaccccggt ccctgtcgac acgtcatggg
     1501 cggcggtgct gcggcacgaa cggatcccgt tcgtctcgca cccctacgag tggtcgtccg
     1561 cgatgctgcg cgacgcggcg ctgctgcacc tcgacgtgct gcgcgccgcc ctggaggccg
     1621 gcttcaccac gaaggacggc tcggcgtaca acgtgcagtg gcgcggcgcg cgacccgtct
     1681 tcatcgacgt cggctcgttc gaggcgctgc gcgacggcga gccctgggcc ggctaccggc
     1741 agttctgcca gacgctgctc tacccgctgc tgatccaggc ccacctcggg ctggacttcc
     1801 agccgttcct gcgggcccgc gtcgacggcg tcgaggcgga ccagatgcgc cggctgttcg
     1861 gcggcgcccg gcgctggcgg gccggtgtgc ccactcacgt gcacctgcac ggcgcgatgc
     1921 aggcccgcaa ctccgccgcg agcaccaccg acgtccgcgc ccagttgcgc gccgccggct
     1981 tctcccgcga gctggcgctg gccacggtac gcggactgac gaaactggtc cgccgcctcg
     2041 accaccggcc gggtggcagc cactggtcgg actaccagcg cacgtgcgcg tactcggtgc
     2101 cggaccggca ggccaaggag gagttcgtcg accgcgcggt ggccgccacc ggcggcggct
     2161 cggcgctgga cctgggcgcc aacgacggcc ggtacgcccg tatcgccgcc cgccacgccg
     2221 cgcacgtcgt cgcggtcgag caggacccgg cggtggtcga cacgctctac cgcgcgctgc
     2281 gcgacgaggg cgagacgcgg atcctgccgc tggtgatgga cctggccgac ccgtcgcccg
     2341 gcggcggctg gcgcggcgtc gagcgggccg cgttcgccga ccgggcccgc gccgacgtgg
     2401 tgctggccct ggccgtcgtg caccacctgg cgatcggacg caacgtgccg ctgcccgagg
     2461 tgctgaacca gctcaccgcg ctcaccgcca ccggcggcag cctggtggtc gagttcgtcc
     2521 acccggacga cccgatggcc cgccgcctgc tcgccaacaa gcccgacggc ctgttcccga
     2581 actaccggcg cgacgccttc gaggcgttgc tggcccgccg gggccgggtg gtcgcccgca
     2641 ccaaactgcc gtccggcacc cgcacgctct accaggtggt ggtgggtggc tgagcgcacc
     2701 ctcgcgccac cccgggacca cgcggccggc ccggaccggc gggaacgccc gccctggtgg
     2761 cggtccgagg cggcgcggct ggcggaggtg acggcgctgg tcgggctggt ggtcacccag
     2821 ccgctgctcg acgtgctcgg ccgcagcccc gacttcttcc tgttccaccg cgcctcccgg
     2881 ggcgacgtgc tgctcctggt cgccctgatc gcgctcgcgc cgacagcgct gttcgcccta
     2941 ctgggcgcgt tcgcgctgct cggcgcgctt gcggtgcccg ccggacgcct cgtccgggcc
     3001 gccgtgcaca ccgcgttcgt cggcctgctg ctcgccgcgc tggcggtcca ggtcggccgg
     3061 cacgtcacgc cgcttcgggg cgtacccctg cttgtggtcg ccggtgtggc cggagccgcc
     3121 ggggcggccg cgcaccggcg gtggcgggcg ccccggcggg tgctgcgggt ggccgccgcc
     3181 gggccgctgg tgttcgtcgg gttgttcctg ttcgcctcgc cggcctcggc ggtggtgctg
     3241 ccgcgcggcg agggtggcgc ggccggggtg gccggcgcgg gcgcgcaccc gccggtggtc
     3301 atgatcgtgc tggacgagct gccgctggtg tcgctgctcg gcccggacgg ccggatcgac
     3361 gccgcccgct atccgaactt cgccgcgctc gcggccgggt cgacctggta ccgcaacgcc
     3421 accggcgtca gcggctggac gccctacgcg ctgcccgcga tgctcaccgg gcgctacccc
     3481 gagcggggcg tggcgccgca ctactcgcag tacccggaca acctgttcac cgcgctcggc
     3541 ggcctgtacc gggtcaaggc cgaagagagc atcacccggc tctgcccgcc gagccgctgc
     3601 gagcaggcca cgaccccgga acaagggctc ggggtgctgg tccgggagag cggaaagctg
     3661 ctgggccgga tcgccgcgcc ggtggacagc cgcgtcgacc cggaggactc ctaccgcgag
     3721 cggaccgccg ccgaggccgg gctggacgcc gccgagccgg tgccggacga ccccaagttc
     3781 cgctgggaca ccctcgacga caaccagccg gcccggttca cctcgttcct ggccgggctg
     3841 cgccccgacc cccggcccac gctgcacttc ctgcacctgc tgatgccgca ctcgccgtgg
     3901 gcgtacctgc cgtccggggc gcactacgcc gcgcccgagg acctgcccaa cgacggcgcc
     3961 ggctgggtcg acctggcccg cgcccggcac ctggcccagc tcggctacac cgaccggctg
     4021 atcggcgaga cgctccggac gctgcgcgcc accggcctct acgaccaggc gctggtggtg
     4081 gtcaccgccg accacggggt gagcttccgg cgggactggc aggggcgcgg gatggacgcc
     4141 atcgaccacg ccgcgaacga ggtggcctgg gtaccgatgt tcgtcaagaa acccggccag
     4201 cgcgccggcc gggtggacga ccgcaactgg gagcacgtgg acctgctgcc cacgatcgcc
     4261 gacgagaccc acatgcgggt gccctggcag atggacggcc ggtcggccgc ggcggccccg
     4321 cgcgagcgca gcgacaagca cttctacgac cacccaggcc agccggtgac gatcaccggc
     4381 ggggtgcccg ccccgctccc gcccgtaccc gtcgacccgc tcgtcggcac ccgggtcccc
     4441 gacatgccgg tgggcgggtc cgccacggtg gcgaaccggg acgccttcga cgcggtcgac
     4501 cctgcgcgcg gcggcctgcc cgcgctggtc tgggggacgg tcccggacga cgtgcccgac
     4561 gggacgcggc tcgccgtcgc ggtgaacggc acggtcggcg cggtggtgcc cgtggtgccc
     4621 cccgacgccg gaggccggcg gttcgcggcg ttcctccccg acgaccggct cttcgccgcc
     4681 ggccccaacc ggctcgacct ctaccgggtc ggcgacgacg ggtcgctgcg ccggctcacg
     4741 ctgtcgtgac gggccctccg ccggcgccca tggtcgcgct cccaaccggt ttccggaccg
     4801 cctggccggg aaacaggtga cgcacacctc accccgaaac catgacgagc ggtgttctcc
     4861 gcgccgtgat tacggtagaa gcgaaggcaa ttcaacgaag atcttgccgg cgaagcgagg
     4921 aacagatgac ggaagtcaag ctcgaccacc ccggtgggca gctgtcgatg ccggtgcagt
     4981 ccgcggttga gggccccgcc gggatcgggg tgagcaagct gctcaaggaa accgggatga
     5041 ccacgtacga ccccggtttc gtgaacaccg cgtcctgctc gtccgccatc acctacatcg
     5101 acggtgatgc cggcatcctg cggtaccggg gttacccgat cgaccagctg gccgagaagt
     5161 cctccttcct ggaggtctcc tacctgctga tctacggcga gctgccgacc cagacgcagc
     5221 tcaccgagtt cagcgagcgg atccggcggc actcgctgct gcacgaggag atgcgccggt
     5281 tcttcgacgg cttcccccgt gacgcgcacc cgatggccgt gctctcctcg gccgtcagcg
     5341 ccatctccac cttctaccag gacagcctgg acccgttcga ctccgagcac gtggagatgt
     5401 ccaccgtgcg gctgatggcg aaggtcccga ccatcgcctc gtacgcgtac aagaagtcga
     5461 tcggtcagcc gctgctgtac ccggacaact cgctcggcta cgtcgagaac ttcctgcgga
     5521 tgaccttcgg cgtgccggcc gagccgtacg aggtcgaccc ggtggtggcc cgggtgctgg
     5581 acatgctgtt cgtcctgcac gccgaccacg agcagaactg ctccacctcc accgtgcggc
     5641 tggtcggctc cagcaacgcc aacctgttcg cctcggtctc cgccggggtg aacgcgctgt
     5701 tcggcccgct gcacggcggc gccaaccagg ccgtgctgga gatgctccag aagatccagg
     5761 ccgacggcgg cgacgtccgc tccttcgtgc ggaaggtgaa ggacaagcag gacggcgtga
     5821 agctgatggg cttcgggcac cgggtctaca agaactacga cccgcgcgcc gccatcgtga
     5881 agaaggccgc ccaggacgtg ctcggccgga tgtccaagcc ggacccgctg ctggacctcg
     5941 cggtgcagct ggaggagatc gcgctcgccg acgacttctt cgtgtcccgc cggctctacc
     6001 cgaacgtgga cttctacacc ggcctgatct acaaggccat gggcttcccg accaagatgt
     6061 tcacggtgct gttcgcgctg ggccgcctgc ccggctggat cgcgcagtgg cgcgagatga
     6121 tcaacgaccc ggagaccaag atcggtcgcc cgcggcagat ctacaccggc gccgtcgagc
     6181 gggactacgt ccccgccgac aagcgctgag cgtgtaagga agggccccct attaacgcct
     6241 ccggtagagg aggggccccc ttttaacacg cggacgacga aggccgccga ccctgctcgg
     6301 gtcggcggcc ctcgtcgcgt gcaccggggt ggagggcgtt aacaaggggc ccttcctcta
     6361 ccggaggcgt taagaagggg cccttcctta ccgcaggccg gcggcggtga ggaggttgcc
     6421 ctcggggact cgcggggtgg ggtggccgtg ggccatgcgg tgctgggccc gggcggcggt
     6481 gaacgcgggg tcgccggcga tggcggccac gtacgcggcg gcggtgcggg acgcgatggc
     6541 ggcccagccg taccgctcgt ggaccatggc gcgggcccgc cgggcgagcg cacgggcccg
     6601 gtcccggtcg gacagcagcg cgtgcaccgc ctcggcgagc ccgtccgggt cgtgcggggc
     6661 gaacgtcatc ccggtgacgc ctggctcgac gatctcggcc agcccgccgg tacgggccac
     6721 tgccagcggc gcgcccgcgg cggccccctc cagcgccacc atgccgaacg gctcgtagat
     6781 gctcggcacc gcgaagcagt ccgaggcggc catcacggcg ggcaggtcgg tgccgccgag
     6841 gaagccgggc atgctgacag ttgcgcccag cccgaggcgg tgcacctcgg cctccagttc
     6901 ggcccggtac ggcccgtcgc cgacgatcac cgcgcgcagg ccggggtgcc gatcgcgcag
     6961 ccggggcagc ccggccagca ggtgctgcac gcccttctcg tacaccagcc ggccggcgaa
     7021 cgtgaccagc gggccgtcgg cggcgaaccg ggcgcgggcg gcggcgaccg ccgacgcggg
     7081 cacccgccag cggtgcggct cgacaccgtt gggcaccacg tcgacgcggg ccgcgtcgac
     7141 gccgaacagc gcgcccacct cgtcgcgcat gtagccggag cagacgatca cccggccgga
     7201 ctcgccggcg agccagtgct cgacgccgtg gatggtgcgg ttcatctcct ccggcagcca
     7261 gccctggtgc cggcccgcct cggtggcgtg gatcgtgctg accagcggta cgtccaggtg
     7321 ctcgcgcagc gtcatcgcgg tgtgcgcgac aagccagtcg tgagcgtgga tcacgtcgta
     7381 ggcgccggac gaggcggcgc gcagcgcggc ccgggtcagc gtgtggttga acgccatggt
     7441 ccaggccagc agcgatccgg tggccagggg gaaggtgacc gggtcctcgg cggcgcggac
     7501 gatgcgcacg ccgtcggcgt actcctccag gggagcgccc tcggcgtggc gggtgacgac
     7561 tgtgacctcg tgcccggcgg cggccagcgc gacggacagc gcgtggacgt ggcggccgag
     7621 cccgccgacg agcaccggcg ggtactccca cgacagcatc aggatgcgcc gggtccgggg
     7681 cgcggccccg gccggtgacg gcggggccgg gcgggaggtg agagtgggcc ggtggagccg
     7741 gtccgtcgcg gtggcgggct gagcgccgac ccgcagagtg gtcacgtcga tctccgtcca
     7801 tgcatggtga ggcacgccgg catcgatggc ggcgacgagc ggtggtcagg agcgaccgga
     7861 cggccggccg ggcgtcggca ccagctcgcc gacgaccgcc tgggccggat accgatcgcg
     7921 ggccaccggg agggtgctga cgtcgatcgg gaaccggaac cgtccagtca ccctgccaac
     7981 ctactgcgcc ggatcctccc gcgcgcggtg agcgatcctc gtcactctcc ggcgcctccg
     8041 tacacataag acggtcacgg gaacgggtgc ggatgcgggt tgatctcctc tggggtgagc
     8101 ggttcggccc ggtgtccgag ccggaccggc aggtcgcgca gccggggcag gtcgacgcgc
     8161 cggttgcggt gaccgaacgt catcggcagc agccccggga tcagcacctt cacgctggtg
     8221 aggccgacgg ccgcctgctc gcgggcggtc tggtcgacga ccaccacgtc caggccctcg
     8281 tcgaggtagc gtccggtcac gtgccgcagg tcgtcgagca ggtccatggc cgggcggtag
     8341 cgcgccgccg gcgggaacgc ctccgccatg gacaggatct cgtcgcgctc gtacaggaac
     8401 gcgaaccgcg gccaggcttc cggactggcc gccgccagca ggtggtcctc catggcccgg
     8461 accaggtcgg ggtcggcgac caggccgggg gctgtggtgt cctcggcgac catctcccgg
     8521 gtggcctcgg cgacgctggc gagctccacc agcgcggacc acagggcacg ctccgggtcc
     8581 aggtgcgccc ccgcaccgca gaacgcccgg ggacgtcccg gccgcacctc gtcgtcgacg
     8641 agcatcagcc acaccgccgg gacgccttcg ggcatggtga tgtcgaagac gtccaggcgg
     8701 ctgccggtgg tccgctggat ccagtcgacg agcacgcggg tcatcgggtc ggcggacgtc
     8761 atcgggtcca cgcgcggcac tggtagccgg gcgtaccagg tggacaggaa cgcgtcccgt
     8821 tcggcgacct cgaagatgcc gtgcaggatc gcctcttcga ggttcgcgcc cagcgcgcag
     8881 ccgttggaac actccggacc gaaacccgtg ccgtgcgagc cgtagtaggc gaaggtctcc
     8941 ggcaccagca ccgggccgtc gcgccggaac gagtaggcgt acacccattc cacgggccgg
     9001 tccgggtcgt acgcgaccgc gtggtcgtcg ggcggcgcgg gcggcagccc gaactccgtc
     9061 ggctcgacgg cccgccgcgg tccgagctcg cggaacgagg cgcgggtgac ggtacggcgg
     9121 gcgcgtggca cgttgccgcc gagccgttcc agcgcctcgg cgacggcgac ggccacgctc
     9181 gccgggtagg tgaaggtccg gccgtagccg gccagttcac cacagcacaa cgggcccccg
     9241 atcgcgccgg cgaggaccat cgggtggttg tggtggacgg tgatcgacga cagcagcccg
     9301 gtctcctcgt cgtgcagcgc cgccagcagc gcgaggtgct cgtcgggaag gctgcgggcc
     9361 cggtagtcgc cgggtgcccg cttcggccgg gacgtcagcg tgaaggtgcc ggcggccggg
     9421 ccgtcgtccg gcaacgggcc gcacaccggg cagccgggtt cggggacgaa ccggtgccgc
     9481 ttgacggcca tcgaggccgt gatgacctcc agcaccgctt ccgcgcaccg gccgtcgccg
     9541 ccctgcgcga cccggcgcag ctcgtcggcc acgagcgcgg ccacagtggc gcgtaccggc
     9601 gggccgagga cgggccgggc gggctgcacg ctgccgtcgt agagcccctg ccacagcgcg
     9661 gaccggtgcg gcgtcccggt ggtccgcgcc cggcgttgcc gcacctggag gcagtggtgg
     9721 cagcccggcc gtccgggcct gacgaagggg ccgattcgta cgccgcgcgg cgtggtgtac
     9781 accggcagga aggcccggcc ggcgtcggca gccgcccggg cggccacctc gacgtcctcc
     9841 ggtggcccgt cgacgacgaa gacgtcgacg tcggcgaccg gggcggcgcc cagcgcctgt
     9901 tccaccgccc ggcgcagggc gccggcaccg aggatccgca ggccgtgacg cggcgtcacg
     9961 tcgggcgagg cggggacggc cggtgtggtc gtgacgtcgg tcatgccctg ctccccgctc
    10021 gtggcgacca cgccgccctg atcatgaacg gcatcacccg ctgcgccccg ggcagcgagt
    10081 cggccggccg caccagcagc gaccgcccgt cccgtgccag ctcgcgcagc agcagcggca
    10141 gcgccgtgtc ccagtcgccg ccgcccacgt ccggtccgat ctcggcgccg tccgggcggc
    10201 gtccggtcag gacggcgacc gccgcctgca tcgcgttcgc cagggcggtg tccgtgtcgg
    10261 tggcgcagct gtgggcgacc catctgtcgc cggcggcgac gaacacggtc ggggtgctcg
    10321 atccgtcgtg ccacgcccgc ggctcgtggc cgaggagtgc cagttcgtgt gccatgacgc
    10381 gggtcggctc cggccaccgc gtccggtcga gccagccgcc gggcggtccg ccgtcggcag
    10441 tggtgacctc cggcggggtc gcggccgcac gtcgcagttt caggatcgcc cggccgcgcg
    10501 cctccgccca ggtgtgaccg cccgcgacca ccacgccgtc cggctgcgcg tcgacgagag
    10561 cgccgcgccc ggcgtcccac cacaccgtgg cggcgtcgtc ggcgcaggcc cgcgccgcga
    10621 gcgtctccag tgccgccgta gcggcgcgca gcagcgcctg ctcccggctg ccgccgacgg
    10681 cggtgagcag ccgcggggcg ccgccggcca ggtccacgac cgtcgcctcg acgcagctga
    10741 ccgagatctg cgagtgagcg ccggtgtcga tggccagcag cgggcccagg cgcgcgtcga
    10801 ccaggaacgg catccgggcg acgaactcct cgacgtccac gggcgtgcgg gcggccatcg
    10861 cgtcgacgtg cgcggcgaga tcggcgtacg caaccggggg ccggcaggag cggcagcggg
    10921 ggtgcacgtc gagcagatgc tcgctggtga cagcggtttc caggtccacg cgggtcatcc
    10981 ggttcgtggc ggtggtctcg gctcccatcc ggtggcgcag gtacgcgaac ccgagcgccg
    11041 cgccgatcag gccgcagacc ggcgccgaca gccactcgga cgtcgtgtcc ggctcgtcgc
    11101 cgtcacccgg ggggagtccg gcgccctgcc ggctgagcag gccgcactcc cagcagccgc
    11161 cggtgacgcc gccgccggtc gggccgatcc acgcctcctc gccgccgggt accgcgtgca
    11221 ggacgggcac cccgatcgcc cgggccgccc ggttcagccg cgtcgcccgc ccggccatcg
    11281 gacgggcggc gcagtgcagc accgcgtcgt accccgccag caggccggcg agaccttcgt
    11341 cggtgtcgag ggcggcggcc gcgtccagca gcgtcagccc ggtcgtcgga tcctcggcac
    11401 gacgccgctg cacgatccgc cggaagccgt cgcgttcggt gccggtctcg gcggtctcga
    11461 ccagcgaggc cgtacgcagc ccgagttcga acagcgtctg gacgagcgcg agcatgccgg
    11521 cgccggcgcc gacgagcagc acccgtccgt tgcggaacgc ctcgaagcgg ctcagcggcg
    11581 cgtcggtgac gtgctcggcg aacgcgatcg agtcccggta gcaggcgagc tcccagtccc
    11641 gcaacgtgtg cggcggctcg ctgtcgaggt cgcgggcgat gccgcgccgc accagcatcc
    11701 cgaccaggtc ggtgacgagc tgccgctgtg ccgcggggag accgtcggtc agctcctgca
    11761 ccgtgcgggt gccgtccagg tgcggggcga gccgctgcac gaggccgtac gccgacgcgc
    11821 ccgccaggtg cgtactggcg agccctgtct ccaggtacac gccgtcgtcg accggcacgt
    11881 acatcaggtc gtcgcggagc ttgaccctca cgcggccacc tccttccgca ggtgtcccat
    11941 ccgcaccgcg accgcgcgtc cggcgtcggt gaacgcctgc cggccgtgca ggtaccggga
    12001 gttgtccacg accagcacgt caccggaccg ccacggcacc gccacagtca gccgcgcggc
    12061 gacgtcagcg gcggtggcca cgaggtcctc gggcaccggt gcgccggtgc cggagcgcac
    12121 ccgcagccgc cggtcgtggt actcgccggg ctgcgggcgg ctgatgaaca gcgagttgca
    12181 gaacgccggc acgccctcga agagggtcgg tggcgtgcac cgggtgccga agccgacagt
    12241 catcgcgtcc tcgtccacgt cgatgtggat cgactcccac ggccgcaggt acggctccca
    12301 ctgccgcagc atccgctccg ccgccgccgg gtcggtcgtg ccgcacatcc gctgccacac
    12361 cggtgtgggc agcgcgctct cccagcgcag cgtcaactcc tcgcaggcgg cgcggaccgc
    12421 ggcgggcagg gcggccagca gcgcgagacc gtcgcacagc gtcgtggccc cgccgtcggc
    12481 ggcgggccgc tcgcaccgga acatcagcag gtccggggcg ccgggcgcgt acgacgcctc
    12541 ccggtgcagc ggcatgccct gcgttccccg ggtgactgtg gtcgtcgtcg ggtcaccgcc
    12601 gatcacgtcc cgctcgtcgt ggaacccgcc ctggtacggc gacgcggtca tcagcgcgtc
    12661 gccgagcgcg acgtagtcct cgtgccgcca cccgccgcgc agcagcaccg cgccgtgctc
    12721 ggcgaccgcc gcgagcaccg tgtccggcgt gggggtgccg acgagcgccg gaacgtcctg
    12781 ttcagccatg agggttccct tcggtgagat gggccgccag caccccggga cgcggcgcgg
    12841 gggtgccgac cagcagttgc gtcagcggcg acgccccgtc cggcaggccg agccgggcgg
    12901 cgaccgcgtc ggcggtgagg ccgcccagcg cgcggctcgc cgcgccggtc gcggcggcgg
    12961 cgagcccggc caggtgaagg gccacgccgg cgagcaggtg cagccggtgg aacgaggccg
    13021 gggagagctg gtcgacgggc cggctcccgg cgtggaccag gtagagggtc gcgccgcggg
    13081 tgaccatccg gcggtcgacc cggtgcgggt acgccgccgt gtcgtcggcc gctcccggcg
    13141 gcccggtcgg caccagccgg tggtggtacg gccggtagcg gtacgcgtcc gccgggatgc
    13201 cgtcgacggt ccgggcgagg caccagatct ccgggtacag cggctgccgg gccagcgccg
    13261 ccagggccgg cgacccggcc cggccggcgg cgcaggccag gatgtcggcg acctgcccgg
    13321 cggtcagccc cgggccgagg ttcgcggcgg aggcgcggcg ggcggcgacc gcgaccaggt
    13381 cgagcggccg ggctggcggc aggtcgagcg cccggcccgc caccgggccc atcgggaggc
    13441 ggtccgccgg gaggcgctgg gccggggagc cgtcggccgg gacggggtcg gcagggagac
    13501 agccggccgg gaggcggtcg gccgaaggcg gctgggcggc ggcgtcccgg tcgtacgtcg
    13561 cccggtgcag cgccaccgcg ctcgggtggg cggcgtcgtg gccgagccgg tcgtggtcca
    13621 gcccggtcgc cgggggcggc ccgccggatg caggcggtgt ccaggggacg tccgcgtccg
    13681 cggggaactc gatcaccgcg taggtggcct ccaactcggc gtcgagtccg agcagctcac
    13741 cggcgagcac cggatcgagg tccaggcgcg gtgtcgcgtc caccggcgac gtgagcatct
    13801 gggccagcag gacaccggag tcgacgatgc ccagccggta gccgaacgct ccgtacttgc
    13861 tggtgttctt ccacggccgg tgggtcagca gcagcgcgtg ccggggcgcc gccgcgaccc
    13921 cgaggagccg gtcgagccgg gcggccgggc tgcccgggcg cagcagttcc aggcagtggt
    13981 gcggcgggtc gtagtggtag acgccggccg ccaggtcggg ggagccggcc caggcgaggt
    14041 agatctcgtt ggggtggaac gccccgccgg agggcaccga gcggcgcagc gtgtgccagc
    14101 cgggcagcag ccgcgacggc gtgggcgtgt ccagcggggc gccggtcaac gcggacagcc
    14161 cggccagcgt gatcgtctcc gcccggcgtg gcgcgtaccc gagaagcatc gcgctgagcc
    14221 ggtcgaggca gccgtcgccg agcggcacgg accccgggcc gggccaccgc agcggccggc
    14281 gggccacgcc cgggtaccgc ttgccgcggg gcggcaggta cgccgtcggc tgcccggtgt
    14341 cggcctgcac cgccgccagg taccggccgg cgacgccggc tcgcgaggct cccatctcag
    14401 ctgcccgcgc tctcgtaccg gcgcaacccg gcccggaaga ccgcccacgc cccggccgcg
    14461 cacgccgccg cgacgaccgg ggtgagcgcg cccgccgtgg tcgaggcgcc cttgtccagc
    14521 agcgcggccg tcgggaagta gccgacgaac gcgacgggta cgagcgtcag cagcgagcgc
    14581 aggccggtgc cgtacagggt cagcggatag cgggccagat cgccgagggt gtgcacgctc
    14641 gccgcgagcg aactggacgg gctcagcagc cagaagacga cagcgttggt ggccaggttg
    14701 accgccagct tgaccagcac cccgctgacg agcagcagcg ccgcccagag caccgtcagc
    14761 ggcgtccagg ccaggtcgag gtggacggcc gcggcgccga gcagcgccgc gccgaacccg
    14821 acgttgccga gaccgttgaa cccgaccgcg ttgccggtga cctggagcac caccgggtag
    14881 ggccggacca gcaggtagtc cagcaggccg aggttgacca ggccgccgag atgccacgtc
    14941 ccctcgaaca gcagggagcc gacgccctcg gcgagcatca ccatggcgca gacgtacagc
    15001 acctcccagc gggtccaccc gccgagcgcc gtcacctgcc ggaacaccat gaccacgaag
    15061 accagcccgg cgagctgacc gagcagtgtc gccccgatcg tcaggagcgc gtcggcccgg
    15121 tactcgagca ccgcccgcag gtgcgcgccg agcaaccggc ggtagatccg tgcctcgtgc
    15181 atcatcggcc ggtcacccgc cgtgcgcggt gagccgccgc acgcccgcgg accacagcag
    15241 ccgggccgcg ccccacaaca ccacgaccca gagcagttgt acgccgatca gcgtcaccgc
    15301 ctcggcgcca cgtatctgcc ccaggtagat cagcgccgga gtggagacga tgccggggaa
    15361 cggggagagc tggcagacga cctggagcca gcccgggaac aacgcgatcg gcaccagcgc
    15421 cccggagagg atgttggtga tcgccacccg cgacaggctc agcccgtgga agttgccggt
    15481 ccagaagcac agcagcccga cgaggtagac caggccgaac ttcagcggca ccaccgccag
    15541 caggctgagc aggaacagtc cggcctgccc ggcggcgggc agcgcggcgc cgccgaacgc
    15601 cgacaccagc gtcgccgcca tcaccgccac cgtcagcacc tcaccgacga cgtatccgag
    15661 cgacagcgcg aaacgcgaga gctggtagtc gatcggccgg accaggtcga gcgccacggt
    15721 gccgtgcagc accgggccgg cgatctgcgc gtcggtgaag ctcgacagca gcgccccggt
    15781 caggaacgcc acgaccaggt agcccttcat ctgctcccag gacaacccgc ccacctcgcc
    15841 gccggccgcg ccggcgaaga ccgcctgcca gaccgcgaac agcgccactg tctgcaccac
    15901 gaccccggtg agctggagga ggaactcgcc ccggtagatc agcagcgtcg accaggacat
    15961 ccgcgccagc gtcaggtacg ccctcatgcc ggcaccgacg ggctcagctc gccggcgtac
    16021 gcccggcgca ccacgtcctc gatggacggc tcgtcgatcc ggatgtccac caccggcgcc
    16081 tggcgggcga ccaccgagac gatctcgccc gcgccgtacg cgccgtggtc gaacgtgaca
    16141 gcgatctgcc gcgccgaccc gtcgtggacc agccggacgc ccggcaggtc ggcgtcgagg
    16201 tcgccgtgcc agtcggcgcc gagcgtcagg tgcacggtcc gctggtcggc gaccagccgg
    16261 cggacggcgt cgatcgagcc gtcgaagatg atccggcccc cgtcgatgat cacgagccgg
    16321 cggcagacct gctcgatgtc accgatgtcg tgcgtggtca tcagcaccgt ggtcccgctg
    16381 gcgcgctggg cccgcaggaa gtcccggacg gcctgccggg cgacgatgtc cagcccgatg
    16441 gtcggctcgt cgaggaacac cacgggcggc gagtgcagca gcgcggcggc caggtcggct
    16501 cgcatccgct ggccgagcga gagctgccgg gcgaccaccg gcagcagccg gccgagcccg
    16561 agcagcgcgt cgaactcctc caggcgtgcc gcgtaccggg cccgggggat gcggtggatg
    16621 tcgcgcagca gggcgaggga gtcgcggacc tgcaggtccc accagagctg gctgcgctgg
    16681 ccgaacagca cgccgatgtt gcgggcgttg gcgtgccggt cgcggtgcgg gtcgaggccg
    16741 cagacgcgta cccgcccggc ggtggggtgc aggatgccgg tgagcagctt gacagtcgtc
    16801 gacttcccgg cgccgttggg cccgacgtac gcgaccgcct cgccggtgga gatcgacagg
    16861 tcgacgccgt cgaccgccac gtgctcgacg tgtcgtggcc gtacgagatg gcgcagcgag
    16921 ccgcgcaggc ccggctgctt gtcggcgatc cggaaccgct tggtcaggcc actggcctcg
    16981 atcactggca tcggtggtgc cgttcccggt cagccggccg cgacggcggc acggtggtgc
    17041 gggcgcagcc gcagcaccga accgaggccg tcgacctcgg tcagggtggt ctcgaacgcc
    17101 gcgcccatga cccggccgag gtagcccagg ctcgccggat ccgggtcgaa ccgcgccgag
    17161 agctccgcgc cggtggagac caggtgcacc tcgtcggcga ggccaccggc gacgttgacg
    17221 aactggcaca ggtcctccca gtagaggtac cgccagaagt cgacgctgac cacggcgtcc
    17281 aggctgtccg cggcgaccgg cggcctgatc ccgaccaggt ggaagttggc cggacccgcc
    17341 ggcgccccgt agtcgtaggt caacgcgccg tcgggcagcc cggcctcggc gctgccggtg
    17401 ccgacccaca gcacccggtc gccgggcagg cgaccggcga gccgctgcac cgccgggccg
    17461 atccggcacc aggaacggcg tacgcagtcg tccatcgccc ggcggtagtg caccacccgc
    17521 tcggccgcgc gggccacgtc caccggcccg gcgaactccc actccacgac cgggtacttg
    17581 agcgcgaccc gatccaggtt gtccatgaag tcgttccagt tctggatgac gttgcggtgg
    17641 tgcggcaggt ggtagacggc ggccaggtcg tcgtaggcga agttgtggtt gagcacgccg
    17701 aggtgcgcgt gcacccggta gaacagctcc atgtcctcca ggccccagcg caggccgaag
    17761 ccctcgtcga agccgcccac cgcctcgaac acgtcccggc gtaccgacgc gttgtgggtg
    17821 aagcagaaca gccagccggc cagcagccag tcgtcgccgg acggtccctc ctcggttccg
    17881 aaccgcatgt cgccgccacc gcgcccgcgg agccggggta cgggcatcgt cggctggtcg
    17941 gccagcgccg cgtgcacgtg ctcgatgccg gtctcgtcgc gccggcccat cagcaccgcc
    18001 ggcgcggacg ggtcgcggtg gtggtcgagg tggcggcgca gcaggtccgg cgtggcgtac
    18061 gagtcggcgt cgaggaacag cagcagcggc gcggtcgccc gtcgcgcggc ctcgttgcgg
    18121 gccgccgccc gcccgccgcg ctcgggccgt tcgacgaagt gcaggcgcag ccccttgccg
    18181 gcgtcggcga tgccggagta ctggctgccg tccccaccgt cgcggaccac gatgacctcg
    18241 aagcggtccg ggtccagcgt ctggcgccgc agcgaccgca gcgtgagctc caggcagggg
    18301 gcgtccgcgt gggtggggat caccacgctc agctcgacgg ctcgaccggg ttcaacgctc
    18361 atctgacgta cctctccgct tgtcccacga gccgggccac cggccgcgct gacgatggga
    18421 cggagccgcc ggcgatcgcc ggcggctccg cgatgatcag tggcagttga cgcagcacca
    18481 ctggatcggc cggccctggc acgcggcgcc gccgcaggag cccttgccca tggcggacgg
    18541 gtcggtcagc gtgatcccgc cggccgtcgg catggcgtag agccctgccg acgcctcgtc
    18601 accggcgccc gaccaggaga ccgcagtggt gtccaggtcg gacaggtcga tcgacgcgtt
    18661 cctgctttca cccatcgatt catcctcttt tcggatcgat gtggacagtg gaacgaagcg
    18721 taggccggac atggcgggat tggcgccgcg ctgatgtaac ggggagataa agcgaggcgg
    18781 aaccgtcaat tcgcgcaggt gacggccggt caggaacgga aaggttgcgg gcggtgacgc
    18841 ggcgtagttc cggatccact attcgagaag ccccagttca ggcggggtcg agcaatgaat
    18901 cgctgcatca attgccccct tttctgatcg tgtgaagtcg atgtaacgag aagataaagt
    18961 gggggagggg cgtctatgaa tgcgggtgac cctctattgt gaagtgacct gcctattccg
    19021 tcgggcccgg ccatgaaatg ccgggacggg tgagcccgac cgtcgcaggg tgcccgaaac
    19081 gtgacacccg gccccacgag ggcggatttc ggttaccgtc cgaacgggtg gattgacgag
    19141 gcgtacgacg gggcatcacc ggcgtgcgca tcggcggccc ctgtccgctg cgctcacgat
    19201 catgggccga aggagcgaca tgcaggtctg gccgggcgag agctaccccc tcggcgccac
    19261 gtacgacggg atggggacca acttcgcgat cttctccgag gtggcggaga aggtcgagct
    19321 ctgcctgttc gacgagtggg acatcggcac cgagcgccgg gtggagctgc gcgaggtcga
    19381 cgcgtacgtc tggcacgcct acatcggcgg cgtcgagccc ggccagcggt acggctaccg
    19441 ggtgcacggc ccgtggaacc cggccgaggg gctgcgctgc aacccgcaca agctgctgct
    19501 cgacccgtac gcgaaggcgg tcgacgggga ggtcacctgg cacccgtcgg tctacgacta
    19561 cgaggtcggc ggcgacccgg accggatgaa caccgaggac tcggcgccgt acatgccgaa
    19621 gtcggtggtg gtgaacccgt acttcgactg gggcaacgac cggccgccgc gcaccccgta
    19681 ccaccactcg gtgatttacg aggcccacgt gcgcgggctg accatgcgcc atccgggcat
    19741 cccggaggag ctgcgcggca catacgcggc gatcgcctcg ccggtgatga tcgagcactt
    19801 caagcggctc ggcgtgacgg cggtggagct gatgccggtg cacgagttcg tgcacgacca
    19861 ccgcctggcc gacctggggc tgcgcaacta ctggggctac aactccatcg gtttcttcgc
    19921 cccgcaccac ggctactccg cgctgggccg cctgggccag caggtgcagg agttccgggg
    19981 catggtcaag gcgctgcacg ccgccggcat cgaggtcatc ctcgacgtgg tctacaacca
    20041 caccgccgag ggcaaccacc tcgggccgtc gctgagcttc aagggcatcg acaccccgag
    20101 ctactaccgg ctctccgagg aggatcggcg gtacttcgtc gactacaccg gcaccggcaa
    20161 cagcctcaac gtgcgcagcc cgcactcact ccaactgatc atggattcgc tgcgttactg
    20221 ggtcaccgag atgcacgtcg acggcttccg gttcgacctg gcggccacgc tggcccgcga
    20281 gttctacgag gtggaccgcc tgtccacgtt cttcgaggtg gtgcagcagg acccggtggt
    20341 gggccgggtg aagctcatcg ccgagccgtg ggacgtcggc ccgggcggct accaggtcgg
    20401 caacttcccg ccgcagtgga ccgagtggaa cggcaagtac cgcgacaccg tacgcgactt
    20461 ctggcgcggc gagccggcca cgctcgccga gttcgcctcc cgcatctccg gctcggccga
    20521 cctctaccag gacgacggcc gccgcccgtt ccacagcatc aacttcgtca cctgccacga
    20581 cgggttcacg ctcaccgacc tggtctccta caacgacaag cacaacgacg cgaacggcga
    20641 ggacaaccgg gacggggaga gccacaaccg gtcctggaac tgcggcgtcg agggggagac
    20701 cgacgacccg ggcgtacgcg cgctgcgggc ccggcagcgg cgcaacttcc tggcgacgct
    20761 gatgctgtcc cagggcgtgc cgatgctcgg ccacggcgac gagctgggcc gcacccagcg
    20821 cggcaacaac aacgcctact gccaggacag cgaactcgcc tgggtcgact gggaccgggc
    20881 cgacaccgag ctgctggact tcgtccgccg gctcaccgag ttccgcaacc ggcaccaggt
    20941 gttccgccgc cgccggttct tcaccggcct gccggtgggc ggccgggccg ccggctccgg
    21001 gctgccggac ctggcctggt acaccccgga cggccgggag atgaccggcg aggactgggg
    21061 caacgacttc ggccgctcgg tggccctgtt cgtcaacggc gacggcatcg gggaacgcgg
    21121 ccagtacggc cagcgccacc gggacgactc gttcctgctg ctgttcaacg cgcacgacgc
    21181 gccgctggac ttcacgctgc ccggcgagga gttcggcagc cggtgggagc tggtgatcag
    21241 caccgcggaa cccgacccgg agaagacgac actggtcgag gcgggcggca cggtctgcgt
    21301 accggaccgc tcgctgctgg tcctggagag gacggcctga cccatgcccg acaccccccg
    21361 ctcgacctac cgggtccagg tgcggcccgg cttcgacctg gacgccacgg ccgagctggc
    21421 gggctacctc gccgcgctcg gcgtcaccca cctctacacc gcgcccctgc tcaccgccac
    21481 gcccggctcc gcgcacggct acgacgtggt cgaccaccgc gcggtcaacc cgcagctcgg
    21541 cggcgaggcc gcccgggcgc ggctggtccg ggcgctgcgc gcggcccggc tgggcctggt
    21601 cgtggacatc gtgccgaacc acgccggcgt cgcccggccg gaggccaacc cggcctggtg
    21661 ggacgtgctg cggcggggac gcgagtcggc gtacgcgcgc tggttcgaca tcgactggga
    21721 ccgggggcgg ctgctgctgc cggtgctcgc cgacagcgcc gacgcgctcg acgacctgaa
    21781 gctcgtcgac ggggagctgc gctaccacga gcaccggttc ccggtcgccg acggcaccgg
    21841 cgacgggacg ccccgccagg tgcacgaccg gcagcactac gaactggtga actggcggcg
    21901 cggcgacgcc g
//
