LOCUS       NZ_CP030865            26464 bp    DNA     circular CON 14-AUG-2024
DEFINITION  Micromonospora sp. B006 chromosome, complete genome.
ACCESSION   NZ_CP030865
VERSION     NZ_CP030865.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora sp. B006
  ORGANISM  Micromonospora sp. B006
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 7040153)
  AUTHORS   Braesel,J., Crnkovic,C.M., Kunstman,K.J., Green,S.J.,
            Maienschein-Cline,M., Orjala,J., Murphy,B.T. and Eustaquio,A.S.
  TITLE     Complete Genome of Micromonospora sp. Strain B006 Reveals
            Biosynthetic Potential of a Lake Michigan Actinomycete
  JOURNAL   J Nat Prod 81 (9), 2057-2068 (2018)
   PUBMED   30110167
REFERENCE   2  (bases 1 to 7040153)
  AUTHORS   Braesel,J., Crnkovic,C.M., Kunstman,K.J., Green,S.J.,
            Maienschein-Cline,M., Orjala,J., Murphy,B.T. and Eustaquio,A.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2018) Medicinal Chemistry and Pharmacognosy,
            University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL
            60607, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 77.6x
            Sequencing Technology :: Illumina; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003408515.1-RS_2024_08_14
            Annotation Date                   :: 08/14/2024 03:31:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,342
            CDSs (total)                      :: 6,278
            Genes (coding)                    :: 6,199
            CDSs (with protein)               :: 6,199
            Genes (RNA)                       :: 64
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 20 of 79
            Pseudo Genes (incomplete)         :: 62 of 79
            Pseudo Genes (internal stop)      :: 6 of 79
            Pseudo Genes (multiple problems)  :: 7 of 79
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:07:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6176719
            Orig. end                         :: 6203183
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26464
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="21"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26464
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26464
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16464](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16464)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            408..860
                     /locus_tag="MicB006_RS27770"
                     /old_locus_tag="MicB006_5558"
     CDS             408..860
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS27770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MicB006_5558"
                     /product="hypothetical protein"
                     /protein_id="WP_116510048.1"
                     /transl_table=11
                     /translation="MDPVRAILLALARRAEEARLSWNAERAALRARGETPTHGNSWPYS
                     VQADLCLITAITAADLPANFRLYDTSLSRDPLAAAAQLREVASAYDHSGPIEAEHEAAR
                     LAYKQAFAEPLTPQEQHYVELLADLPAARRDKVIEAAEERLRHRPA"
     gene            1093..1371
                     /locus_tag="MicB006_RS27775"
                     /old_locus_tag="MicB006_5559"
     CDS             1093..1371
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS27775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MicB006_5559"
                     /product="hypothetical protein"
                     /protein_id="WP_116510050.1"
                     /transl_table=11
                     /translation="MSLYTLIPKPGFDRYTIQVGWSPHRTYVATLVDFTWDPVTEPDRQ
                     PAVIHLGRVETILDPAEVLSAFEPYADIPAELPARLRADQAKHPVRR"
     gene            1613..2296
                     /locus_tag="MicB006_RS27780"
                     /old_locus_tag="MicB006_5560"
     CDS             1613..2296
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR00254.1"
                     /locus_tag="MicB006_RS27780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5560"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_152037893.1"
                     /transl_table=11
                     /translation="MSRPLLMIATAVVAYVLGRLTAWPTIHRLRHQLADTHRSMLYDPL
                     TGMLNRAGLRAVHAALADEPSAQPIIVALIDLDDFKHVNDTHGHDHGDELLIAIGDRIA
                     DLAAVHGGAAARLAGDEYAVLLPTRAGEPDRIADALATIIAEPVALGTDEHSVTASIGL
                     ALVEATDPLTDVALHRADVAMYHAKRNGRNRYATYQPGMTMPPAPHRRGPRLRDRRRPI
                     DGAPA"
     misc_feature    complement(1632..1647)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.98"
                     /tool="antismash"
     gene            2293..3597
                     /locus_tag="MicB006_RS27785"
                     /old_locus_tag="MicB006_5561"
     CDS             2293..3597
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS27785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MicB006_5561"
                     /product="hypothetical protein"
                     /protein_id="WP_152037894.1"
                     /transl_table=11
                     /translation="MTTPLEEMACRTCLVPLNTLGTPPTHVHPVHLATDGHTPEPVPVS
                     QLATVRRTCDFCGDPYPIWTLHGANVTAVAIGSTATVVQNFGETWAACATCQTHIDDSR
                     PDLVVDRAVQALDVRTNPEVRGRIQELHLAFLDARLPDRTLLTTTPWPAASIAAKDLPK
                     VRDRLTHLYRGNDHLPAALGLTETRAQVADGLDQSRLYWIDDDFTDLAEHAATQLTALT
                     IGHDLGPPANVLITWSRPVTQHQITAASWTLANDGWQVVLYRAIGAGLDGKPLQRLREQ
                     VGWLVPMTAAHLTEQHLIDADHPAAALFATWLLITQKAAEVDVARVDKTIAKAYARTKR
                     DQPEVRIVRIRGRRSPSDAAETTPGEQGRRQSSRFWVSGHWRNQAHGPGRSLRRPVYIN
                     PFLKGPAESPVKSSTTVRMLSSHKPQGEEGTPRPA"
     gene            complement(3768..7910)
                     /locus_tag="MicB006_RS27790"
                     /old_locus_tag="MicB006_5562"
     CDS             complement(3768..7910)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="MicB006_RS27790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5562"
                     /product="response regulator"
                     /protein_id="WP_161565961.1"
                     /transl_table=11
                     /translation="MPLGSPLVAELGKRSWRVGDDPLRARWLRLAACHSTYLYEFDRPP
                     ISVAALALLGKVGATHLALAGADLVVERTRPDKVGKQNHLVAHMPGCIAKQVADSLAVA
                     ESMNLGRGEEPNRRTTSRLAEDVMHQALGVVVLLGGYTTVRRLVTEVYEQALQQVLTEG
                     IDWWGELARLVPVQQLRIRDDEEGPDHDRTFTREIVDNRGRRGRGDSPKRTGARHLAAQ
                     DYLRNVGLYGEVVARLGDRSISRLTEAPRRFASADGLQERTITELAATLRLAAEHKAYL
                     QQALTHKSWTYENQPLVRQARQRDYELLANHGSFVVRAVSAAEFTRDLLRRTLKPEPED
                     GAIHSLPERCYVDMFDRLVAESAVLRGRGEAECKPRMKAEAFQAIVAVAWRFGEAGLPE
                     TLRGWILRETRARELDELSRLQRLCTAFGGEISPSYTSAGPAHDSRFTATLTLRIGEIE
                     IVRTGPPTPGRKEATRLAAEQLYQLFTLRSDFPASGGTAAEREESMLLLRHLARRLSML
                     RGRDLRRCVEDGVLGLGLLAASDGSLRDFLNWAKEVDSLVGPMDDEVFNDLVAAYGSVV
                     KARSRPRLEDALRDLAAWVRNLDPEGNVVVRGAPQWELLLAVAGALRAGAAREQKTVNQ
                     LSGSWPVQGPESTSLLSAVDAAAISELLREFSNASVGTVDFRRASDGVQLECVTTAPDA
                     AHRVRTLVGLLAETAPGLEVVAGPDTHTISAAYSPGPADRSFAAAGSLADGCQDQDGIE
                     ILANVLHRLKNELIGMEDVAQKAALATERVTRFHRLADAARHHEAALQLANHLDRTNRA
                     LADADEETVELGRWLDEYCAAKVLELRDRANVRLIAPANSGQCEVAFSASLLRGVLDNL
                     VKNAVEAMPNGGQIIVDWYTEPGHVFLIVHDDGPGLPAEIRETFWRDETVTTTKEHGSG
                     MGLWLVRMDLRRLGATISDDPAAHGQRWVIDLPREEVIGGLPERRSATSPQVRAASRRT
                     VRVLLVDDQENVARTMAGHLESIARVEIAHDGESALTRLSTEHYDIVVTDLQMPPEPWG
                     GLWLLGRMKDEGRRVPVVVLSGEGSFDQAIDALNAGAFKYVTKADAAEKLAAVVEEVLS
                     HLRRHSRSDLQHLPLPVALGLQRYESEMVANLRVRAGHAALEDALRFISAVGIGELVGG
                     HPDARVPRPALASQMMLGKRVELLKVLESRLAQDSYAGQVIRSLDLDALAVVKTGRNVV
                     SHNSERPNDEVTRMLDEVDPLLEQFATALRHIPDRTVMIAQGLRFDAKRYRVTAFHVTG
                     TGPVLPSTEITSDIPLAENSVGLYNPSTGSWVPVGPWMTARPGDTRGEWQISVVEGVNL
                     RTTLPAKLAYQPFGGGTKWAAEADESANELIRRSVAR"
     misc_feature    complement(4149..4151)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(6138..6140)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(7827..7829)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8195..8821)
                     /locus_tag="MicB006_RS32520"
     CDS             complement(8195..8821)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013734050.1"
                     /locus_tag="MicB006_RS32520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="G5 domain-containing protein"
                     /protein_id="WP_225980533.1"
                     /transl_table=11
                     /translation="MSTHDHQQRGGNLRSIIVSATILAVLGFGAVAVDAVTDGEIARGP
                     APAPASTTSGATRIAATDAAKSSPAVTPSRAVVETLTVTATEPVPYRTKKVKDSSMPKG
                     ITKLRTRGVEGTRTLRYQVTVIDGVETARKVVKTQVTTKPVTEVVAVGTKNCDLNYQGC
                     VPIASDVDCAGGSGNGPAYVKGPVKVIGYDIYKLDRNNDGYGCDE"
     misc_feature    complement(8498..8500)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8901..10004)
                     /locus_tag="MicB006_RS27800"
                     /old_locus_tag="MicB006_5564"
     CDS             complement(8901..10004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019901919.1"
                     /locus_tag="MicB006_RS27800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5564"
                     /product="hypothetical protein"
                     /protein_id="WP_116510057.1"
                     /transl_table=11
                     /translation="MTVESDSALFRRFPLVARPRPIAGPLAARIDDLCALAERAAREDD
                     RAAASAAYNQAALLASDCGQPDLARRWCHEHAAPYLRAVPLDAQAARHALEPLVNLARL
                     HIRDRDGDAALRLLTSLFEAVSSRTDAMIDGQALPASRLTRGEDDHREVRRWLWSVLVA
                     EGARALASAGRWSEAHEHLKRHHGIGQRMLDGRQVAMIAHLAAGHIVLARSMVAETAPG
                     EPWEDAVTACLAYLCDRSSEGQLRLAVDGYLRMQPAKPLAIFQARLGMTLIDAAGGTAD
                     APLLRLASTLVANCAAWGDARVAREILRHQGMAAGISHRQAVQLAEFVLNSGLGRGRLP
                     SWAEKRLSNFLALCHSTFESDRPPGRP"
     gene            complement(10001..12064)
                     /gene="fxlM"
                     /locus_tag="MicB006_RS27805"
                     /old_locus_tag="MicB006_5565"
     CDS             complement(10001..12064)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="MicB006_RS27805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5565"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_116510059.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-33, bitscore:
                     115.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 2.2e-42, bitscore: 143.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPMPGWRQYTVEFPDPTAAEDVAASVLAPALAAAQNESVLHGWWY
                     VRKYPTWRWRYLADDPTSHRVEDLLETLAGQDRITNWTRGVYEPETLAFGGSAGMQVAH
                     ELFHQDSRHVLLGLPPATTLGRRELAVLLCSVLMRGAGLDWYEQGDTWAKVADLRPSPG
                     LAVPEQAAAELARAINRLMTVDAHSLAKTDGPLVGLSPWLDAFATAGQALADLARHGRL
                     RRGLRAVIAHHVIFHANRLGLSVQDQSTLAALAVRNVFHHTTRSTVSIAEPTPTSTSVD
                     RVTSDPADLRAALTDGLRAENIIRTPGVEAAIRATPRHLFLPGVPLKQAYADAPVYTKT
                     DGRGASISAASQPRIVAMMLEQLDVRPGHRVMEAGAGTGYNAALLAALTGDNGRVVTLD
                     VDEDLVDGARKHLATVGVTNVDVILGDGALGCPDGAPYDRIIATVGAYETPTAWLEQLA
                     PDGRLVVPLRLRGAASRSIIFERYDGGWRDQGSELAVFMPLRGIGGDARRQVPIALEQD
                     VILQVHKEQDVDAAALAGVLDTERRRIWTNVFFPPMVPYEWMDLWLACRLDNAIMRMNV
                     QPAAIERGAVTPMFPWGAMATTRGADLAYLTIRPTPTRPGDSRLYEVGVIGHGPDGAGL
                     AALVSEEIRVWNATYRSRRVRFEIPDAPVEADPSAGRFFLPRPQHPITVTWQ"
     gene            complement(12074..13360)
                     /locus_tag="MicB006_RS27810"
                     /old_locus_tag="MicB006_5566"
     CDS             complement(12074..13360)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018808311.1"
                     /locus_tag="MicB006_RS27810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5566"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_116511892.1"
                     /sec_met_domain="LANC_like (E-value: 1e-40, bitscore:
                     138.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPYESHDLAVAVADLLAHPDDPRLPIQQPWWRQSLALGVPGIA
                     LLHVELAAAGLRPWQRPHHWLAAATSRPVTAGPDSHPFHGAPALAYVLACAATHRPGAY
                     AHALEELDQVITADARRRVAAAHARIDVGELPALAEFDAIRGLTGVGAYLLRRAPDGEE
                     LPAVLGYLVRLTRPLPVGSEVLPGWWTGSGPSGHVDSRFPGGHGNHGMAHGIAGPLALL
                     ALAALHGIVVDGQTAAIARICTWLDRWRHDSMAGALWPYWITRPQLRADRAATHRVQRP
                     SWCYGTAGLARAQQLAALALNDHVRRATAEGTLVRALADPCQLAATTDPSLCHGHAGLA
                     QIAHRMAADALPDTAGTLGPLVSRLLGALDPDGAGPRRTAVALVAASPGLLEGAAGVAL
                     AALSCSSAGAHTSSWDACLLTAPIAHPLT"
     misc_feature    complement(12806..12808)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13357..16464)
                     /locus_tag="MicB006_RS27815"
                     /old_locus_tag="MicB006_5567"
     CDS             complement(13357..16464)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018805746.1"
                     /locus_tag="MicB006_RS27815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5567"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_225980534.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.3e-198,
                     bitscore: 658.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.6e-20,
                     bitscore: 69.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4e-21, bitscore:
                     74.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSPTGSPAYRSTGAALVRAAAHPHIDLPPWPDLTEPRHALVPGW
                     VAWLRQVWTNETLVDAISHASPVLAAQVARLCAGDALTVRETRRVIQAVARYTQRLRGR
                     PTPFGLLAGVAPAVFGSRSPTRWGTAHQAVARAGAAWLADMISHLERCPDLVARLSVVA
                     NNTMTVRDDRLVLPYQPHARPQGTTAVEVSLRYTAPVRAAITAAHAPIRVEALSAQLCA
                     AFPRAAPATVEGMLAELITRGALITSLHAPGTEPDALAYLLLQLDDVDAGGIAAVADLV
                     RALRDIHTALRRHRTAHGADGRQARAQVTSRMRALGISVHEPLAVDLRLDASVTLPDQV
                     AREVERAALALTRLSAHPYGTAAWRAYHQRFYERYGIGSLVPVRDVVDPDSGIGFPDGY
                     PGTPADEPRSPLSRRDELLLALAQRAALDGADEVLLDEELIAELELGPPRLRLPAHLET
                     SVRVHAAGEAALARGRFTVEVTSVSRGAGGLTGRFLSVLRAVDAAKLAAGLTDLPTADH
                     DTVPAQMSFPPLDPATTHVTRAMQILPTVISLAEHRRPNRSVLTVDDLAVGCDGRRMYL
                     AAPDQGHRFEAVGMHALNLRTHTPPLARFLIELGRAQCAQVTAFDWGAAARAKLPFLPR
                     IRYGRAILAPATWRPEATELPDRRQPWYAWDDALDQWRARRRLPRLVQLVEADRRLPLD
                     LDESAHRVLLRTHLLTAPRAVLVEAPTPQDLGWCRGRPHEVILTLHATERPPWPPLPTP
                     TPARVIGRDQCLSPAASPLLLAKLYGDIRRQDLLLAEHLPRLLTEWEVPPDWWFLRFRD
                     PDQHLRLRIALPDPSAFGPAAGRVSAWADDLRRRGLLREIQYATSYPETGRWGSGAAMQ
                     AAEAVFIADSHAVLTQLRQPVRPRRQALVAAQIAAIAVAYTGNVDAGMRWLIDHVPPTA
                     PQPVERPLFHEAVRLAHPGDDWAALRAVPGGTAIVDAWKNRDIALAVYRTHLPGPHTDG
                     INSDDLLGSLMHAHYIRAVGIDFDDEDRCRYLARAAALAYFARSRP"
     aSDomain        complement(15709..15984)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_MicB006_RS27815_Lanthipeptide_LanB_RR
                     E.1"
                     /evalue="3.40E-22"
                     /identifier="RREFam001.1"
                     /label="MicB006_RS27815"
                     /locus_tag="MicB006_RS27815"
                     /protein_end="252"
                     /protein_start="160"
                     /score="69.9"
                     /tool="antismash"
                     /translation="VVANNTMTVRDDRLVLPYQPHARPQGTTAVEVSLRYTAPVRAAIT
                     AAHAPIRVEALSAQLCAAFPRAAPATVEGMLAELITRGALITSLHAP"
     gene            complement(16563..16721)
                     /gene="fxlA"
                     /locus_tag="MicB006_RS27820"
                     /old_locus_tag="MicB006_5568"
     CDS             complement(16563..16721)
                     /codon_start=1
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018829768.1"
                     /locus_tag="MicB006_RS27820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5568"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_104113317.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.4e-13, bitscore:
                     47.2, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSTAEQSTTADGGDFDLDVSLLEVADVAGLVNLTDDGCGSTCT
                     ACTTNVA"
     gene            complement(16805..17503)
                     /locus_tag="MicB006_RS27825"
                     /old_locus_tag="MicB006_5569"
     CDS             complement(16805..17503)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013734802.1"
                     /locus_tag="MicB006_RS27825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5569"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_116510063.1"
                     /transl_table=11
                     /translation="MTVPSTGVSIRRATPADIDPLVSVLVDAFFDGPVADWLVPDHDDR
                     RAVYRRYFTLVLRHGLTHGHVDTTTDRSAVAIWYARPVPPPAAPPEHQAAVEAATGPYA
                     PKFTLLEAMFDVFHPREPHHYLAYVAVSPDEQSSGVGTALLDSYHRRLDALGLPAYLEA
                     SNMRNRRLYLRLGYRAGPPLILPISGPTIWRMWRGPAGAAGTAAFPDTEQRPRRRTRPT
                     AASSSVRIGR"
     gene            complement(17518..19011)
                     /locus_tag="MicB006_RS27830"
                     /old_locus_tag="MicB006_5570"
     CDS             complement(17518..19011)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013734803.1"
                     /locus_tag="MicB006_RS27830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5570"
                     /product="APC family permease"
                     /protein_id="WP_116510064.1"
                     /transl_table=11
                     /translation="MSHSTTDTVSEVLARGRLGIPSVVFFVIAAAAPLTVVAGGATTGY
                     AVTGVAGIPVAYLVVAAVLALFSVGFVAMSRRIVNAGAFYTYVTRGLGRPAGVGAAMVA
                     LVAYNAMQIGLYGGFGAVLATFLRDQYGLNLTWWVPALIGWAVVAVLGVLRIDLNGRVL
                     AVMLVAECAVALVFDAVMVGHPAGGTVTFDTLAPSHILAAGIGAALVTAITGFVGFEGT
                     VVFSEETRDPRRTVARATYIAVAATGLLYGLSAWAMSVATGPDRIVDAARTDGTDLIFN
                     LVSPHLGSSIVTVGRVLFITSLFAALLSFHHTVARYLFALGRERVLPGVLGRTSRRTGA
                     PKVGSILQSILAVVVLIAYATAGADPIVHLFFWVTVTGGLGVLILMTVTSAAVIGFFAR
                     IAHGEGWWPAFVAPLLATLTLTGFLAATLREFDILLGVSAHSPLRWLFPATYAIAALAG
                     IAWALVLRATRPQVYDAIGLGADSATAPLRRTDSFRLPV"
     misc_feature    19010..19025
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    complement(19022..19035)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.86"
                     /tool="antismash"
     gene            complement(19048..19785)
                     /locus_tag="MicB006_RS27835"
                     /old_locus_tag="MicB006_5571"
     CDS             complement(19048..19785)
                     /GO_function="GO:0070273 - phosphatidylinositol-4-phosphate
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018831754.1"
                     /locus_tag="MicB006_RS27835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5571"
                     /product="GPP34 family phosphoprotein"
                     /protein_id="WP_225980535.1"
                     /transl_table=11
                     /translation="MNPALGAADEHAASYVRSEPVPVPRPAPAGAASAPTGRIADEFFF
                     MCHDDRTGRPRLFDSALSHGLAAGLLVELYYGGRITFERGHVRVKDIRPPQDWLQHLVL
                     DRIAAEQQHTATRVWLAFLGASAYEQVAQRMWQSGLVRPQQAGPFWRQRTLYVPTDINT
                     AAWSWARLSQHLRNGRSLNGVDLALAGLALHTQLDTTLLDGASLATRSHLRRLVEQSWP
                     PLRDLLADLGSVVGGAVLSHRTS"
     gene            20636..22012
                     /locus_tag="MicB006_RS27845"
                     /old_locus_tag="MicB006_5572"
     CDS             20636..22012
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024816.4"
                     /locus_tag="MicB006_RS27845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5572"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_116510068.1"
                     /transl_table=11
                     /translation="MQRVVRPQWWHEGTFRGAAIRVHLARHDMAAAFGFLKERGFSWSA
                     IATATGLGASRVSEIAAGRRVVTDYAVLERIAEGLSIPRHFMGLALDEQALHHRRGDAP
                     EPARSAGPLDPHELLGVVASIAVGAIPEGVERWLPNSQKTALPATVGPDEVATVRAVTA
                     FHRRLDAAAGGGRCLQSACGYVAWATQLLQVKCADTVAVDLRTALAELHNLVGWVAHDF
                     DDHDMARRHLTQSLVLARQTDSLPLLANTLYRLGRVSLHQGQPAEALQLFGLGQLAAQQ
                     AGCHASVGILHANSAWAYALLGADHQVVDSLSRARRELDRADPDTAPAWTHFALTEADG
                     HGISAVVYSALARHPEHLRYVERAAEHSHQAVQLRRPQDRRSFIFDTISVATASILAGD
                     LATAGEYGTKAVGLVVDGGMRSARVNDRLDALWALAAPKAEREPALAALGSRLAELRAV
                     "
     gene            22012..22986
                     /locus_tag="MicB006_RS27850"
                     /old_locus_tag="MicB006_5573"
     CDS             22012..22986
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="MicB006_RS27850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_5573"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_116510069.1"
                     /sec_met_domain="APH (E-value: 3.8e-11, bitscore: 41.9,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTALSDAVASELRAHLGEVCAELGIEPDSARLVKYTMNAVFEAP
                     PFVIRLAAGPHAFTLAERVVPVAQCLEKAGMPTVRISSGVACRPIFSGEWVATAWQYVP
                     TVRDEPRPVDLAMPLRALHGLEQLNVPLPRWSPIPKFRRRLDAAASLPPREADDLEGWS
                     RTELGLSTQDLLRDLRWRCDRAEEDLDRVAWQLPPGVIHGDAHTGNILLPLPGQGASSP
                     TPLLCDLDGVCLGPREWDLVPTAHGATRFGRSRIDYEDFVDAYGVDVTTWTGWPVLRGV
                     RELQLVTSTIDALAGRPDVAKQLAHRLRSLFSGDLEATWCRYR"
     gene            complement(23054..23866)
                     /locus_tag="MicB006_RS27855"
     CDS             complement(23054..23866)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS27855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116510071.1"
                     /transl_table=11
                     /translation="MNRLYVYPRLPAHVAERLLTLHTGRDLVELRRLSATADARTTWYP
                     TAPHRVAEDDLRALQQTVRGIAAEANWPAPLGKTNGTAFDRLLAPALYRQMTIVPADAA
                     SEEVWSFLSLVLLPDIALWRWPNPLRRPGYERIIGRPRNVFRRLWTRVHSLGEDLGARL
                     YEDEAVAILERPTLGAHPRVARAIAHGHLTVAGEAGAARTDILRITARRLRRLAVLVSL
                     ESLDDVQLSKLVDDYTKEAIEQLQAKTTGSTPDHDLPEQVRARSGASL"
     gene            complement(23863..24753)
                     /locus_tag="MicB006_RS27860"
                     /old_locus_tag="MicB006_5574"
     CDS             complement(23863..24753)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS27860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MicB006_5574"
                     /product="hypothetical protein"
                     /protein_id="WP_116510073.1"
                     /transl_table=11
                     /translation="MSAPISAGHLTPAEERIQSGTVTVTGPQGTPVPEGEPVPDWDYFT
                     DLTANWPLHVDLPGVLQDCGLSPAAAVHCLVTWHSSSTNRRDNSTPARLVDGENRLTVA
                     IPGTEIGGNLTLTARMVLAAPDPTPISPLAAFRPGAILWQARRRFTLEGSGSRFPVVAT
                     SFAESGLAEGRRSLWYLSCAPDLDGSDTGSIRLYLNSDHPAVTTMLNQPEAEASRTLAE
                     VLRHDVVRQLIQTALRCEDLQDEHDHGEGTLGELFINLIRRYFPDRSLSDLRSQHRNDP
                     SELEAVIQGLDRVLA"
     gene            complement(24750..26219)
                     /locus_tag="MicB006_RS27865"
                     /old_locus_tag="MicB006_5575"
     CDS             complement(24750..26219)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="MicB006_RS27865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="MicB006_5575"
                     /product="hypothetical protein"
                     /protein_id="WP_152037895.1"
                     /transl_table=11
                     /translation="MLFEASSIDTVVIFTRIRTSAGTECRLIGMSLTDPYRVGRHQYTG
                     RHWWGVPHSDVGVEPVTGPAAEHMARAIGLTHLSGDATGTSVMVIAPRTGEEHLSDVVA
                     VMADTATRYAWANTVGQVGSPPGLTLRFTCDGSRIDLPDPATDARLRYFVEAHRRCRSV
                     FDGAAGDHPWPWAVQEIVGSRPEQRLGVLAWRTYRAAASGSHARPPAEIALMRRPGLVV
                     EYRNVTPDPFGHAISGVFIADPELDGDFARAEPPTHDRWQPRLAQRQRYARNPVSQALN
                     RIDRIFKERRTDNATTPTTEAATGVSRLANVLGTLLDTQAGGTDIRIPAGSDNPVHDPP
                     TTSSGAPAGHNDTPTVHNGGKGRQQRHHGRGSRSTTGPTLRFHPRPRQIVLRDGGRAVE
                     FDIDLTGASGASLTLIAQPLVAIADGAPEPADETTPVEVLHWRDRDNGDLTPGPQLTLT
                     TETSEHWTVTLTQPADAAVTVRIRQEEVTPT"
ORIGIN
        1 gcgctacgtc gacacgacgc gggagcgcga ctcaccgatg acgaggtggc gtggctgacc
       61 acattgctgg tcgaccggga tatccgggac gtcgccgtcg gcctcaccga gccacacagc
      121 cggcacgtcg acttctgggc tgacatcacc cgccgcgccg acgagccgct cgtaccggca
      181 ccggccaccc tgctcgccgt caccgcctgg cgctgcggcg acggcgtcct cgccgccatg
      241 gccgccgaac acgccctcca catcgacagc acctaccagt tcgccgagac ggtccttcac
      301 gccctacagg ccggggtgcc cccgaccgtc atcgaggagg ccctcgccga cgccgactcc
      361 gaaccgctcg ccctgcccga cgacccgatg gaacaggagt aacgatcatg gatcccgttc
      421 gcgccatcct gctggccctc gcccgccgag cagaagaagc ccggctgtcc tggaatgccg
      481 agcgtgctgc tctgcgcgcc cgcggcgaaa cacccaccca cggcaactcg tggccttaca
      541 gcgtccaagc cgacctctgc ctgatcaccg ccatcaccgc agccgacctg cccgcgaact
      601 tccgtctcta cgacacctcg ctgtcccgag accccctcgc cgcagccgcg caactccgcg
      661 aggttgcctc cgcctacgac cacagcggcc cgatcgaggc cgaacacgaa gcagcccggc
      721 tggcgtacaa gcaggccttc gccgaaccgc tcaccccaca ggaacagcac tacgtcgaac
      781 tgctcgccga tcttcccgcc gcacgccgag acaaggtcat cgaggcggcg gaggaacgtc
      841 tccgacaccg tccggcttga gccccagctc gccgcgacgc ctgccgcccg ggaggtcagt
      901 ctcccgtcgc gcctatcgca gtacgcgcgt gacaggcccg agcagcgcca gcctttccgc
      961 aggggtcaag agcgggggag cgcggcaccg gagaactagt gccgctggcg gtctccgggt
     1021 gagcctttgc ggcttgcggg tcgtcgtagg cgtggactcg gcaacgtcgc gagatctccg
     1081 cgaaaggaac ccatgagcct ctacaccctg atacccaagc cgggctttga ccggtacacg
     1141 atccaggtcg gctggagccc acaccgcacc tacgtcgcca ccctcgtcga cttcacctgg
     1201 gacccggtga ccgaacccga tcggcaaccc gccgtcatcc acctcggccg ggtcgagacc
     1261 attctcgacc cggccgaagt gctctcggcc tttgagccct acgccgacat ccccgccgag
     1321 ctcccggcca ggctccgcgc cgaccaggcc aaacacccgg tacgccgctg acaccatctc
     1381 gcgaccagtc acgaggtgac tggctgctgt cgtatctgca gtgcggttcg acgtgccgct
     1441 gtccggcgcc gccggcctgg ccctggcccg aacgctctcg gcaccagtgc cgcgattcct
     1501 gcagcaagaa ccgaaactgg cccgccactg gcgggccgtc gtcgtatcag gatccgggac
     1561 gcgccgccta cgaaacgtcc gcgtcccggg ttctcccgaa aggaggaccc cagtgtcccg
     1621 accactgctc atgatcgcca ccgccgtggt ggcctacgtc ctgggccggc tcaccgcctg
     1681 gccgaccatc caccgcctac gccaccaact cgccgacacc caccgctcga tgctctacga
     1741 cccgctcacc ggcatgctca accgcgccgg cctccgcgcc gtccacgccg ccctcgccga
     1801 cgagccctcc gcccagccga tcatcgtcgc cctgatcgac ctcgacgact tcaagcacgt
     1861 caacgacacc cacggtcacg accacggcga tgaactcctc attgccatcg gcgaccgcat
     1921 cgccgacctc gccgccgtcc acgggggcgc cgccgcacgg ctcgccggcg acgaatacgc
     1981 cgtcctccta cccacccgcg ctggcgaacc ggaccgcatc gccgacgcgc tcgcgacgat
     2041 catcgccgag cccgtcgccc tcggcaccga cgagcactct gtcaccgcca gcatcggcct
     2101 ggccctcgtc gaagccaccg atccgctcac cgacgtcgcg ctccaccggg ccgacgtcgc
     2161 catgtaccac gccaaacgca acgggcggaa ccgatacgcc acctaccagc caggcatgac
     2221 catgccaccc gcgccccacc gccgcggacc acgcctgcgc gaccgccgac gcccgatcga
     2281 cggagcccca gcatgaccac cccactcgaa gagatggcct gccgcacctg cctggtcccg
     2341 ctcaacaccc tcggcacacc acccacccac gtccacccgg tccacctcgc caccgacgga
     2401 cacacccccg agcccgtccc ggtcagccaa ctcgccaccg tccgccggac ctgcgacttc
     2461 tgcggcgacc cctacccgat ctggacgctg cacggcgcaa acgtcaccgc cgtcgccatc
     2521 ggctccaccg ccaccgtcgt gcagaacttc ggcgagacgt gggcagcatg cgccacctgc
     2581 caaacccaca tcgacgacag ccgcccagac ctggtcgtcg accgcgccgt ccaagccctc
     2641 gacgtccgca ccaacccgga agtacgaggg cgcatccagg aactgcacct ggcattcctc
     2701 gacgcccgcc tccccgaccg cacgctcctc accacaaccc cctggccagc ggcatccatc
     2761 gcagcgaagg acctgcccaa ggtgcgcgac cggctcaccc acctctaccg aggcaacgac
     2821 cacctgcccg ctgcgctcgg acttaccgaa acacgcgccc aggtcgctga cggactcgac
     2881 cagtcgcgcc tgtactggat cgacgacgac ttcaccgacc tcgccgaaca cgccgccacg
     2941 cagctcaccg ccctcaccat cggccacgac ctcggcccgc cggccaacgt actcatcacc
     3001 tggtcgcggc ccgtgaccca acaccagatc accgccgcct cctggacctt ggccaacgac
     3061 ggctggcagg tggtcctcta ccgcgccatc ggggccggac tcgacggcaa acctctgcaa
     3121 cggctccggg agcaagtcgg ctggctcgta cccatgacgg ccgcccacct caccgagcaa
     3181 catctgatcg atgccgacca ccccgcagcc gccctgttcg ctacatggct gctgatcact
     3241 cagaaggccg cagaggtcga cgtcgcgaga gtcgacaaaa ccatcgccaa ggcctatgcc
     3301 cgtacgaagc gggaccaacc agaggtgcgc atcgtgcgga tccgcggccg ccgcagcccg
     3361 agcgacgcag cagagacgac gccgggggag caagggcggc gtcagagtag ccggttctgg
     3421 gtttccggcc actggcgcaa ccaagcccac ggcccaggcc gatcgcttcg ccgcccggtc
     3481 tacatcaatc cattcctgaa ggggccagcc gagtcgccgg tgaagagcag taccaccgtt
     3541 cgcatgctca gcagccacaa accgcagggt gaggagggga caccacgacc agcgtgacct
     3601 gatgccagtg gtgacagggg cctcgtcccc tgtcaccact atcagcaaga gctcagctct
     3661 gcgtacagtc gcctccacgg agaccatcgg ccgacactca ccatgcactg agccggcgaa
     3721 aagccaagga cgcgcgccgg ttgcctgccg gtgcagcaaa ccctccctca ccttgcaacc
     3781 gagcggcgga tcaactcatt ggcgctctca tcagcttctg ccgcccactt cgtgccgcca
     3841 ccgaacggtt ggtaggcgag ctttgctggc agggtcgtgc ggaggttgac gccttcgaca
     3901 acggagatct gccactcgcc gcgtgtgtcg cctggccggg cggtcatcca cggaccgact
     3961 ggcacccacg aacctgtgct ggggttgtac aggccgaccg agttctcagc tagagggatg
     4021 tcgctggtta tctcggtact cggcagcacc ggaccggtac cagtcacgtg gaacgcggta
     4081 acccgatacc gtttggcgtc gaagcgcagg ccctgagcga tcatcacggt gcggtccggg
     4141 atatgacgta aggctgtcgc gaactgctcc agcaatggat ccacttcgtc gagcatgcgg
     4201 gtcacctcgt cgttggggcg ctcggagttg tgactgacca cgttgcgacc ggttttcacg
     4261 acggcgagcg cgtccagatc cagactgcgg atgacctgcc ccgcataaga gtcctgtgcc
     4321 agccgcgatt cgagcacctt cagcagttca acacgtttgc ccagcatcat ctgagatgcg
     4381 agtgccggcc gtggcactcg tgcgtccggg tggccgccca cgagttcgcc gatccctacc
     4441 gcgctgatga agcggagtgc gtcctccaag gccgcatggc ctgcccgcac tcgcaggttg
     4501 gccaccatct ccgactcgta acgctgcagg ccgagtgcca ccggtagtgg tagatgctga
     4561 aggtcgctgc ggctgtgccg gcggagatga gacaggacct cctcgacgac ggcagcaagt
     4621 ttctctgccg cgtccgcctt ggtcacgtac ttgaaggcgc ccgcattgag tgcatcgatt
     4681 gcctggtcga agctgccctc accggaaagc acaacaaccg gcactcggcg gccttcatcc
     4741 ttcatacgcc caagcagcca cagcccaccc cagggctcgg gtggcatctg caggtcggtg
     4801 accacgatgt cgtagtgctc ggtgctgagc ctggtcaggg cgctttcacc atcgtgcgcg
     4861 atctctaccc gggcgattga ctcaaggtgc ccggccatcg ttcgagcgac gttctcttgg
     4921 tcatccacga gcaacaccct gaccgtgcgg cgggacgcag ccctcacctg cgggctcgtc
     4981 gccgatcgtc gctccggtag gccgcctata acctcctcgc gcggcaggtc gatgacccac
     5041 cgttggccat gcgcggccgg gtcgtcggag atcgtggcac ccagccgacg taggtccatg
     5101 cggaccagcc acagccccat gcctgagccg tgttccttgg tggttgtgac cgtttcgtca
     5161 cgccagaatg tctcgcgaat ctcggcgggc agccctgggc cgtcgtcgtg aacgatgagg
     5221 aatacatgac ctggctcggt gtaccagtcg acgatgatct ggccaccatt cggcatcgcc
     5281 tcgacggcat tcttgacgag attgtctaga accccccgca gcagcgacgc cgagaacgcc
     5341 acctcacact ggccggagtt ggcgggcgcg atcaggcgta cattggccct gtctctgagc
     5401 tctaggacct tggcggcgca gtactcatca agccagcggc ccaactcgac tgtctcttcg
     5461 tcggcatccg ccagcgctcg gttggtgcga tccaggtggt tggccaattg gagggccgct
     5521 tcgtggtgcc gggcggcatc ggcgagccgg tggaagcggg tcacccgttc ggtggccagc
     5581 gcagccttct gcgcgacgtc ctccatgccg atcagctcat ttttcagcct gtgcaggacg
     5641 ttcgccaaga tctcgatgcc gtcctggtcc tggcagccgt ccgcgaggct gccggcggca
     5701 gcaaaggacc ggtcggcagg cccaggggag taggcggcgc tgatcgtgtg cgtgtcgggt
     5761 ccagcaacca cctcaaggcc aggcgccgtc tcggcgagta ggccgaccaa ggtacggaca
     5821 cggtgggctg cgtccggggc tgtcgtgaca cattcaagct gcacgccgtc ggaagcccgc
     5881 cggaaatcga ccgttccgac ggaggcgttg gagaattcgc ggagcagctc actgatggca
     5941 gcagcatcaa ccgcggagag gagtgaagtc gactcggggc cctgcactgg ccacgagccg
     6001 gacagctgat tcaccgtctt ctgctcccgg gcggcaccag cccgtagcgc tccggccacc
     6061 gccaggagga gctcccactg gggtgccccg cgaaccacga cgttgccttc cgggtcgaga
     6121 ttccgtaccc aggccgctaa gtcccgcaag gcgtcctcta gcctcggccg cgatcgtgcc
     6181 ttgaccacgc tcccgtaagc ggccaccaga tcgttgaaga cctcgtcgtc catcgggccg
     6241 acaagcgagt caacttcctt cgcccagttg aggaagtcgc ggaggctgcc gtccgaggcg
     6301 gccagcaggc ccaatcccag aactccgtct tctacacagc gtcgaaggtc acggccacga
     6361 agcatcgaca ggcgccgagc caggtggcgc agaagtagca tgctctcctc acgctccgcg
     6421 gctgttccgc cagacgccgg aaagtctgat ctcagggtga agagctggta caactgctct
     6481 gcggccagcc gtgtggcctc cttcctcccg ggagtcggag gaccggtgcg aacgatctcg
     6541 atctcgccga tacgaagagt cagggtcgcg gtgaagcgcg agtcgtgcgc cgggccggcg
     6601 gaggtatagc tcggggagat ttcgccgccg aaggcggtac agaggcgctg cagccggctc
     6661 agctcgtcga gttcccgcgc gcgggtctcc cgcaatatcc aacctcgcag cgtctccggg
     6721 aggccggctt caccgaagcg ccaggcgacc gccacgatcg cctggaaggc ttccgccttc
     6781 attcggggtt tgcattcggc ctcgccgcgc ccgcgaagca cggccgactc cgccacgagg
     6841 cggtcgaaca tgtcgacata acaacgctcc ggaagcgaat ggatcgcacc gtcctccggt
     6901 tcgggcttga gcgtgcggcg cagcaggtcg cgggtgaact ccgccgccga caccgccctg
     6961 acgacgaagg acccgtggtt ggccaagagc tcatagtctc tctgccgggc ctggcggacc
     7021 aacggctgat tctcgtaagt ccatgactta tgcgtgagag cttgctgcaa gtaggccttg
     7081 tgctctgcag cgagccggag tgtggcggct agttctgtga ttgtgcgttc ctgtaggcca
     7141 tccgctgatg cgaagcgacg gggcgcctcg gtgagccgcg agattgagcg gtcaccgagg
     7201 cgcgcgacga cctcgccgta gaggcccacg ttgcgcaagt aatcctgggc cgctaggtgc
     7261 ctcgcgccgg ttcgtttcgg ggagtcacca cgcccacgtc gtccccggtt gtcgacgatt
     7321 tcccgtgtga acgtccggtc gtggtccggg ccctcttcat cgtcccgaat tctgagctgt
     7381 tgaacgggca cgagccgggc cagctcaccc caccagtcga tgccttccgt gagcacctgc
     7441 tggagtgcct gctcgtagac ctccgtcacc agccgcctga cggtggtgta gccgccgagg
     7501 agcaccacca cgccgagggc ttggtgcatg acgtcctcag ccaggcgcga cgtggtccgg
     7561 cgattaggct cttcgcctct gcccaggttc atggactcgg cgacggccag gctgtcggcg
     7621 acctgcttgg caatgcagcc gggcatgtgt gcaacgagat ggttctgctt gccgaccttg
     7681 tcgggacgag tgcgctccac caccaggtcg gctcccgcga gcgccagatg ggtggcccct
     7741 accttgccta gcaaagccag tgcagcaacc gagatcggcg gccggtcgaa ctcgtacagg
     7801 taggtggagt gacaggccgc gagccgtaac caccgtgccc gcagcgggtc atcgcctacc
     7861 cgccagctgc gcttgccgag ttcggccacg agcgggctac cgagcggcac gtcatccgcc
     7921 gtagcgggca ggctgggaag agaggcgagg gcggatcggg gcatgccggc ggtgtcctcc
     7981 aggtaacgaa aagttcgggc aactctagcc ggaccgcatg acacaaggga cggtcgtaag
     8041 tcgttgagcc gtgcgtaagc tggtcgacaa cggcgcaggg tgaagctgcc agtcaagttg
     8101 tacgcgcata tttccaggaa ccggggccgc gccgtgcgag gcggagttgg cgtcgtgagt
     8161 tcggggggcc acggccgagg gcgagacctg cgacctattc gtcacagccg tagccgtcat
     8221 tgttccgatc aagcttgtag atgtcatagc cgatcacctt caccggaccc ttcacgtagg
     8281 caggtccgtt gccgctgccc cccgcgcagt ccacgtcgct cgcgatcggt acgcagccct
     8341 ggtagttcaa gtcgcagttc ttcgtcccga ctgcaacgac ctcggtaact ggcttcgtcg
     8401 tgacctgcgt cttgaccacc ttccttgctg tctctacccc gtcgatgaca gttacctggt
     8461 acctgagtgt cctggtgcct tccacgccgc gtgtccgtaa cttcgtgatg cctttcggca
     8521 tcgacgaatc cttgaccttc ttggtccggt atgggactgg ctcagtagcg gtgacggtca
     8581 aggtttccac cacggcgcgg cttggtgtga cggcgggcga cgacttggcg gcatccgtcg
     8641 cagcgatcct ggttgcgcca ctcgtagtgg atgccggtgc gggcgccggt cctcttgcta
     8701 tctcgccgtc ggtgaccgcg tctacggcta ctgcgccgaa cccgagcacc gccaagatcg
     8761 tggcgctgac aatgattgac cttagattcc cgccgcgctg ttgatggtcg tgggtgctca
     8821 cgttggttag tgtggcggac caccgccaga agcgtccggc ctcggcgagc ataatgggac
     8881 gcgttcgtcc ggtgatatga tcatggccgc cccggcgggc ggtcgctttc aaaggtcgag
     8941 tggcacaagg caagaaaatt cgagaggcgc ttctctgccc agcttgggag ccggccacgg
     9001 ccgaggccgc tgttcagcac gaattccgcg agctgcactg cctggcggtg gctaatgcct
     9061 gccgccatac cctggtggcg gaggatctcc cgagcgactc gagcatcgcc ccaggcggcg
     9121 cagtttgcga ccagagtcga agcgagacgt agcagtggcg catccgctgt tccgccggcc
     9181 gcgtcgatta gcgtcatacc gaggcgagcc tggaagatgg cgagaggctt cgctggctgc
     9241 attctgaggt aaccgtccac cgcaagcctc agctgtccct cggaagacct gtcacacagg
     9301 taggccaggc atgcggtgac cgcgtcctcc cagggttcgc caggggcggt ctccgcgacc
     9361 atcgagcggg ccaacacgat gtggccagcc gccaggtggg cgatcatcgc tacctggcgc
     9421 ccatcgagca tccgttggcc gatgccgtga tgtcgcttga gatgttcatg cgcctcgctc
     9481 caccggcccg cgctggccag cgcacgggca ccctctgcga cgagcacgct ccacagccat
     9541 cgcctgacct cgcggtggtc gtcctcaccg cgagtcagcc ggctcgccgg cagggcctgg
     9601 ccgtcgatca tcgcgtccgt ccgtgacgac actgcctcga agagactcgt gaggagtcga
     9661 agggcggcgt cgccgtcgcg gtcgcgaata tgcagccgag cgagattgac caagggctcc
     9721 agcgcgtggc gtgccgcctg cgcgtccaga ggaacggccc gcaggtacgg ggcggcatgc
     9781 tcgtggcacc accgacgggc cagatccggc tggccgcagt ccgaggcgag gagagcggcc
     9841 tggttgtagg cggccgaggc cgcggctcgg tcgtcctctc gggcggcgcg ttccgccaac
     9901 gcgcacagat cgtcgatgcg ggcggccaac ggtccggcga tgggccgtgg tcgcgcgacc
     9961 agtgggaagc gccgaaacag cgcgctgtcc gactccacgg tcactgccag gtgacggtga
    10021 tggggtgctg cggccgggga aggaagaagc gtccggccga ggggtccgcc tcgacgggag
    10081 cgtcggggat ctcgaagcgg acccgccggg agcgataggt ggcattccag acgcggatct
    10141 cctcgctgac gagagccgcg agacctgcgc cgtccgggcc gtgaccgatg acgcctacct
    10201 cgtacagtct gctgtcgccg ggtctggtcg gcgttggcct gatggtgagg taggcgaggt
    10261 cggcgccgcg ggtggtagcc atcgcgcccc acgggaacat cggggtgacg gcgccgcgtt
    10321 cgatggctgc gggttggacg ttcatgcgca tgatggcgtt gtcgagccgg caggccagcc
    10381 agaggtccat ccactcgtac ggcaccatcg gcgggaagaa cacgttggtc cagatcctgc
    10441 gccgctcggt gtccagcacg ccggccagtg ccgcggcgtc gacgtcctgt tccttgtgca
    10501 cctgcaggat cacgtcctgc tccagtgcga tcggcacctg ccggcgggcg tcgccgccga
    10561 tgccgcgcag cggcatgaag acggccagct cgctgccctg gtcgcgccac ccgccgtcgt
    10621 accgctcgaa gatgatcgag cgggaggcgg cgccacgcag gcgcagcggt acgacgagtc
    10681 gcccgtccgg ggcgagctgc tccagccagg cagtcggggt ttcgtaggcg ccgacggtgg
    10741 cgatgatccg gtcgtagggt gcgccgtcgg ggcagccgag cgctccgtcg ccgaggatga
    10801 cgtccacgtt cgtgacgccc acagtggcaa ggtgtttgcg ggccccgtcg acgaggtcct
    10861 cgtcgacgtc gagggtgacg acgcgtccgt tgtcgccggt gagggcggcg agcagggcgg
    10921 cgttgtagcc ggtgccggcg ccggcttcca tgacccggtg gccgggtcgt acgtcgagtt
    10981 gttcgagcat cattgccacg atccgtggct gtgaggcggc gctgatggag gcgcctcggc
    11041 cgtcggtctt ggtgtagacg ggagcatcgg cgtacgcctg cttcagcggt acgccgggta
    11101 ggaacaggtg ccgcggggtg gcgcggatgg cggcctcgac gccgggcgtg cggatgatgt
    11161 tttcggcgcg cagtccgtcg gtgagcgcgg cgcgcaggtc ggcggggtcg ctggtcactc
    11221 gatcgacgct agtgctcgtg ggcgtgggtt ctgcgatcga cacggtgctc ctcgtggtgt
    11281 ggtggaagac gttgcggacc gcgagcgcgg cgagggtgga ctggtcctga acggacaggc
    11341 caagtcggtt ggcgtggaag atgacgtggt gtgcgatgac ggcgcgcagc cctcgtcgaa
    11401 ggcggccgtg tcgggcgagg tcggcgagcg cctgcccggc ggttgcgaag gcgtcgagcc
    11461 atgggctgag ccctacgagc ggtccgtctg tcttcgcgag gctgtgggcg tcgacggtca
    11521 tgagccggtt gatcgctcgg gccagttcgg cggcggcctg ctctggcact gcgaggccgg
    11581 gggagggccg caggtcggcg accttcgccc aggtgtcgcc ctgctcgtac cagtccagac
    11641 cggcgccgcg catcaggacg ctgcacagca gcacggcgag ctctcgcctt cccagcgtgg
    11701 tggcgggagg aagtccgagt agcacgtgtc ggctgtcctg atgaaacagc tcgtgggcta
    11761 cctgcatgcc ggccgacccg ccgaaggcca gggtctccgg ttcgtagacg cctcgggtcc
    11821 agttggtgat tcggtcctgg cccgcgagtg tctccagcag atcctccacg cggtgggagg
    11881 tcgggtcgtc ggcaaggtag cgccaccgcc aggtggggta cttccggacg taccaccagc
    11941 cgtgcagcac gctctcgttc tgtgcggcgg ccagcgccgg ggccaggacg gaggcggcga
    12001 cgtcctcggc tgcggtgggg tcggggaact cgacggtgta ctgccgccag ccgggcattg
    12061 gcattcgacg tcctcacgtc aggggatggg cgatgggggc ggtgagcagg caggcgtccc
    12121 aggagctggt gtgcgcgccc gcgctgctgc agctgagggc ggccagcgcg acgccggcgg
    12181 cgccttcgag caggccgggg ctcgcggcga ccagggcaac tgcggtacgc cgaggcccgg
    12241 cgccgtccgg gtcgagcgcg ccgaggagcc gagaaaccag cgggccgagc gtcccggcgg
    12301 tatcgggcag ggcgtcggcg gccatccggt gcgcgatctg ggccaggccg gcgtggccgt
    12361 ggcagagcga cgggtcggtg gtcgccgcga gctggcacgg gtcagcgaga gcgcgtacga
    12421 gtgtgccttc ggccgtggcg cggcggacgt gatcgttcag ggccagggcg gcgagttgct
    12481 gggcgcgcgc cagcccggcg gtgccgtagc accaggacgg ccgctgcacg cggtgggtcg
    12541 cggcgcggtc cgcccggagt tgcggtctgg tgatccagta cggccagagc gcaccggcca
    12601 tggagtcgtg gcgccatcgg tcgagccagg tgcagattct cgcgatggca gcggtctgac
    12661 cgtcgacgac aatgccgtgc agggccgcga gcgccagtag cgccaagggt ccggcgatgc
    12721 cgtgggccat gccgtggttg ccgtgtccgc cggggaagcg ggagtcgacg tggccggaag
    12781 gcccgctgcc ggtccaccag cctggtaaca cctcgctgcc gacgggtagg ggtcgcgtca
    12841 gccggaccag atacccgagc accgcgggca gttcctcgcc gtcgggtgct cggcggagca
    12901 ggtacgcccc gaccccggtc aatcctcgga tggcgtcgaa ctcggcgagc gccggtagtt
    12961 ccccgacgtc gatgcgggcg tgcgcggcgg ccacgcggcg tcgcgcatcg gcagtgatca
    13021 cctggtcgag ctcctcgagt gcgtgcgcat aggcgccggg ccggtgggtg gcggcgcagg
    13081 cgaggacgta agcgagcgcg ggtgcgccgt ggaaggggtg gctgtcgggg cccgccgtta
    13141 ccggtcggct ggtagcggcg gcgagccagt ggtgggggcg ttgccagggt cttagccctg
    13201 ccgctgccag ctcgacgtgg agcagggcga tgccgggtac gccgagggcg agcgactgcc
    13261 gccaccaggg ttgctggatc ggcagccggg ggtcgtcggg atgggcgagc agatcggcga
    13321 ccgcgacagc gaggtcgtgg ctctcgtacg gaagggtcat ggccggctcc gggcgaagta
    13381 ggccagggcg gcggcgcggg cgaggtagcg gcaccggtcc tcgtcgtcga agtcgatgcc
    13441 gaccgcgcgg atgtagtggg cgtgcatgag ggagccgagg aggtcgtcgc tgttgatgcc
    13501 gtcggtgtgc ggtccgggta ggtgggtccg gtagacggcg agggcgatgt cgcggttctt
    13561 ccaggcgtcg acgatggcgg tgccgccggg gacagcgcgc agtgcggccc agtcgtcgcc
    13621 ggggtgggcg agtcgtacgg cttcgtggaa cagcggccgc tcgaccggct gcggcgcggt
    13681 cgggggtacg tggtcgatga gccagcgcat gccggcgtcg acgttgccgg tgtaggcaac
    13741 ggcgatagcg gcgatctgcg cggcgacgag tgcctgtcgg cgcgggcgga cgggctggcg
    13801 tagctgcgtg aggacggcgt gggagtcggc gatgaagacc gcctcggcgg cctgcatggc
    13861 cgcaccggat ccccaccgcc cggtctcggg gtaggaggtg gcgtactgga tctcccgcag
    13921 caggccacgt cggcgtagat cgtcggccca tgcgctgaca cgtccggcgg ccggtccgaa
    13981 tgccgacggg tcgggcaggg cgatgcggag gcggagatgc tggtcggggt cgcggaaccg
    14041 gaggaaccac cagtccggcg gcacctccca ctcagtgagc agtcggggca ggtgctcggc
    14101 gaggaggagg tcttgtcggc ggatgtctcc gtagagtttc gcgagcagca gcggagaagc
    14161 ggcagggctc aggcactggt ctcgtccgat gacgcgggcc ggcgtcggtg tgggcagggg
    14221 tggccagggt ggtcgctcag tggcgtgcag cgtcaggatg acctcatgcg gacggccgcg
    14281 acaccagccg aggtcctgcg gggttggtgc ttccacgagg accgctcgcg gtgcggtgag
    14341 caggtgggtg cgcagcagga cgcggtgcgc ggactcgtcg aggtccagcg gcagacgccg
    14401 gtcggcttcg accagctgca ccaggcgggg caggcgccgg cgggcccgcc actggtcgag
    14461 ggcgtcgtcc caggcgtacc agggctgccg ccggtcgggc agctcggtag cttccggccg
    14521 ccaggtggcg ggggcgagga tcgcgcgtcc gtagcggatg cggggaagga acggcagctt
    14581 ggcccgggcg gcggcgcccc agtcgaaagc ggtgacctgg gcgcactggg cgcggccgag
    14641 ttcgatgagg aaccgggcca gtggtggggt gtgggtgcgc aggttgagcg cgtgcatgcc
    14701 gacggcttcg aagcggtggc cctggtcggg tgcagcgagg tacatgcgtc ggccgtcgca
    14761 gccgaccgcc aggtcgtcga cggtgagtac cgaccggttc gggcgccggt gctcggccag
    14821 gctgatgaca gtgggcagga tctgcatggc gcgggtgacg tgggtggtcg cgggatccag
    14881 cggcgggaac gacatctggg cgggcaccgt gtcgtgatcg gcggtgggca ggtcggtcag
    14941 gccggcggcc agcttcgccg cgtcgaccgc ccgcaacacg ctgaggaacc ggccggtgag
    15001 tcccccggcg ccccgcgaca cggaggtgac ctcgacggtg aacctgccgc gcgccagggc
    15061 ggcttcgccg gcggcgtgca cgcggacgct cgtctccagg tgtgccggta gccgcagccg
    15121 tggcggcccc agctccagtt ctgcgatcag ctcctcgtcg agcagcacct cgtccgcgcc
    15181 gtccagggcg gcgcgctggg cgagggcgag gagcagctcg tcgcggcggg acaggggtga
    15241 tcgtggctcg tctgctgggg tgccggggta tccgtcgggg aagccgatgc cgctgtccgg
    15301 gtcgacgacg tcgcgtaccg gcaccagcga gccgatcccg taccgttcgt agaagcgctg
    15361 gtggtaggcg cgccacgccg cggtgccgta ggggtgggcg ctgagccggg tcaacgccag
    15421 ggcggcgcgt tccacctccc gcgccacctg atcgggcagc gtgaccgacg cgtccagccg
    15481 gagatccacc gcgagaggct cgtggacgga gatgccgagg gcacgcatcc gggaggtcac
    15541 ctgggcgcgg gcctggcgac cgtctgcgcc gtgggcggtg cggtggcgtc gtagcgcggt
    15601 gtggatgtcg cgcagggcgc ggaccaggtc ggcgaccgcc gcgatgccgc cggcatcgac
    15661 gtcgtcgagc tggagcagca ggtacgccag ggcgtcgggt tccgtgccgg gcgcgtgcag
    15721 gctggtgatc agtgcgccgc gggtgatcag ctcggcgagc atcccctcaa cggtcgccgg
    15781 tgcagcgcgc gggaacgcgg cacacagctg cgcggacagt gcttccaccc ggatcggggc
    15841 gtgggcggcg gtgatcgcgg cgcggaccgg cgcggtgtac cgcagcgaca cctccacggc
    15901 cgtcgtgccc tgcggtcggg cgtgcggctg gtagggcagg acgagccggt cgtcgcgtac
    15961 cgtcatggtg ttgttcgcga ccaccgaaag ccgggcgacc aggtccgggc atcgttccag
    16021 gtggctgatc atgtcggcga gccacgcggc gcccgcccgg gcgacggcct ggtgtgcggt
    16081 gccccatcgg gtgggcgagc gtgatccgaa cacggcgggt gccaccccgg cgaggagacc
    16141 gaacggggtc ggccggccgc gtaggcgctg cgtgtatcgg gcgacggcct ggatcacccg
    16201 ccgggtttcc cggacggtga gggcgtcgcc ggcgcacagc ctggcgacct gcgcggcgag
    16261 taccgggctg gcgtggctga tcgcgtcgac gagggtttcg ttcgtccaca cctgccgcag
    16321 ccatgccacc cagccgggga cgagggcgtg gcgtggttcg gtcaggtcgg gccacggcgg
    16381 caggtcgatg tgggggtggg cggccgcgcg gacgagcgcg gccccggtcg accggtatgc
    16441 tggagagcct gtgggagagc gcacgctgca cctcgggtgg atgtcggttc gggtgccggc
    16501 cggcgcggaa gatgggggcg tgttgccgcg ccggccggcc tttccgggga agggttcgtc
    16561 ggtcaggcga cgttcgtggt gcaggcggtg caggtgctgc cgcagccgtc gtcggtcagg
    16621 ttgaccaggc cggccacgtc cgccacctcc agcaggctga cgtccaggtc gaagtccccg
    16681 ccgtcggcgg tcgtgctctg ctccgcggtg ctggtggaca tgtcttcctc cgatcttgag
    16741 atcccttcgg gccgaggtga cccgaggtgg tgccgggtgg ccgcgtcccg gtgacgcgtc
    16801 acccctaccg cccgatgcgg acggagcttg aagcggcagt cggccgggtt cgccgacgtg
    16861 gtcgttgctc ggtgtcggga aacgcggccg tgcctgcggc gccggccggc ccgcgccaca
    16921 tccgccagat cgtgggtccg ctgatgggca ggatcagcgg cggcccggcc cggtagccga
    16981 gccgcaggta cagcctgcgg ttgcgcatgt tgctggcctc caggtaggcg ggcagaccca
    17041 gcgcgtcgag ccggcggtgg tagctgtcga gcagggcggt tccgacgccg gagctctgtt
    17101 cgtcggggct gaccgccacg tacgcgaggt agtggtgcgg ttcgcggggg tggaacacgt
    17161 cgaacatggc ctcgaggagg gtgaacttcg gggcgtacgg tccggtggcg gcttccaccg
    17221 ccgcctggtg ctccggcggc gccgcgggtg gaggtacggg ccgggcgtac cagatcgcga
    17281 cggcggaccg gtcggtggtg gtgtcgacgt ggccgtgggt gagaccgtga cgcaggacga
    17341 gggtgaagta ccggcggtag acggcgcgac ggtcgtcgtg gtcggggacc agccagtcgg
    17401 cgaccggccc gtcgaagaac gcgtcgacga gtacggagac caaggggtcg atgtcggcgg
    17461 gagtggcgcg acggatgctc acgccggtgc tggggacggt catggtgagc tccttgttca
    17521 gaccggcagg cggaagctgt cggtgcggcg caggggcgcg gtggcgctgt cggcgccgag
    17581 tccgatggcg tcatagacct gcggccgcgt tgcgcgcagg accaacgccc aggcgatgcc
    17641 ggcgagggcg gcaatggcgt aggtggccgg gaagagccag cgcagcggtg agtgcgcgct
    17701 gacgccgagg aggatgtcga actcccgtag cgtggcggcg aggaacccgg tcagcgtgag
    17761 cgtggcgagc agcggcgcga cgaacgccgg ccaccagccc tcgccgtggg cgatgcgggc
    17821 gaagaagccg atcacggcgg cggaggtgac ggtcatcagg atcaggacgc cgaggccacc
    17881 ggtcaccgtg acccagaaga acaggtgcac gatcgggtcc gcgccggcag tggcgtaggc
    17941 gatgaggacg accaccgcga gaatgctctg caggatcgat ccgaccttcg gggcgccggt
    18001 gcggcggctg gtccggccca gtacgccggg caggacccgc tcccggccga gcgcgaacag
    18061 gtaccgggcc acggtgtggt ggaagctcag cagcgcggcg aacaggctgg tgatgaacag
    18121 gacccgcccg acggtcacga tgctggaccc gaggtgcggt gagacgaggt tgaagatgag
    18181 gtcggtgccg tcggtgcggg ccgcgtcgac gatcctgtcc gggccggtgg cgacggacat
    18241 cgcccaggcg gacaggccgt agagcaggcc ggtggcggcc accgcgatgt aggtggcccg
    18301 cgcgaccgtc cgacgtgggt cacgggtctc ctcggagaac accaccgtgc cctcgaagcc
    18361 gacgaaaccc gtgatggccg tgaccagtgc ggcaccgata cccgcggcga ggatgtgcga
    18421 cggggcgagg gtgtcgaagg tgaccgtccc gccggcgggg tgcccgacca tcaccgcgtc
    18481 gaagaccagc gcgaccgcgc actcggcgac gagcatgacc gccaggaccc tgccgttgag
    18541 gtcgatgcgc agcacgccga gcacggccac cacggcccac ccgatcagcg ccggcaccca
    18601 ccaggtgagg ttcaggccgt actgatcgcg caggaacgtc gcgaggaccg cgccgaaccc
    18661 gccgtacagg ccgatctgca tcgcgttgta cgccaccagc gcgaccatcg ccgcgccgac
    18721 accggccgga cggccgagcc ctcgggtgac gtaggtgtag aacgcgccgg cgttgacgat
    18781 ccgccgggac atggccacga acccgaccga gaacagcgcc agcacggcgg cgacgacaag
    18841 gtacgccacc ggaatacccg ccacgccggt gaccgcgtag ccggtggtcg caccgccggc
    18901 gaccaccgtc agcggcgcgg cggcggcgat gacgaagaac accaccgagg ggatcccgag
    18961 ccggccgcgc gccagaacct cggaaacagt gtcagtagtc gaatgcgaca tcaggtctct
    19021 ttcacgaaga gtggatgggt gttgccgtca ggaggtgcgg tggctcagga ccgcgccgcc
    19081 gacgacgctg ccgagatcgg cgagcagatc ccgcaacggc ggccacgact gctcgaccaa
    19141 ccgccgcaga tgcgagcgcg tcgccagcga ggccccgtcg agcagcgtcg tgtccagctg
    19201 ggtgtgcagc gccaggccgg ccagcgcgag gtccacgccg ttcaagctcc ggccgttgcg
    19261 caggtgctgg gacagccgcg cccacgacca tgccgcggtg ttgatgtcgg tcggcacgta
    19321 cagggtgcgt tgccgccaga acgggcccgc ctgctgcggc cgcaccagac ccgactgcca
    19381 catccgctgg gcgacctgct cgtaggcgga cgcgccgagg aaggccagcc acacccgggt
    19441 cgcggtgtgc tgctgctcgg ccgcgatccg gtccaggacc aggtgctgga gccagtcctg
    19501 cggcggccgg atgtccttga cgcgcacgtg cccgcgctcg aacgtgatcc gcccgccgta
    19561 gtagagctcg acgagcagcc cagcggccag gccgtgcgac agcgccgagt cgaacagccg
    19621 aggtcggccg gtccggtcgt cgtggcacat gaagaagaac tcgtccgcga tccggccggt
    19681 cggcgcggag gcggcgccgg cgggcgccgg acgggggacc gggacaggct cggaacggac
    19741 atacgaggcg gcgtgctcgt cagcggcgcc gagggctgga ttcaccgcgg ccgtccttcc
    19801 tgaatcgtgt cgtctgcgga gtcgagaagc tggagctgta cgaggaggcg agggccaccg
    19861 ggatgacggg acagctcctc cagcgcccac tcgttctggc gacatacgcc gtcgtggcac
    19921 tgaaagcagg ctccgccctc cttgtgggcg agcacggtcc ggcgagccgc gtcgaagcgg
    19981 tcgacgggac ggtcgctctc ctcgacccca gtcacggcgc gggagtgtgg actggccgtt
    20041 gcggcggcga tccccggcgc ggccggaata ggatgtgagt caccgccttt acagtcactc
    20101 cggcggacga tgctccgccg ccgcggctcc tgatcggctc gtacgactgg cagtgcttcg
    20161 gaggggcggg ccatgcgaag cgggtcatcc ggacacctcc tcatcaaggt gcgcggccgg
    20221 gccctacccg acatcgaccg cgtacccggc tcatgtgcat gagcagtctc ggattcggag
    20281 cacgcgcgta ggccgtcgtg ggcgcgcgct cggccgatgc tgctccgtgc agccctcacc
    20341 ccaagccggc gcccatctac gacctgagaa accacgtcgg cgacgaggcc cagtgtcgga
    20401 acctgcccgc cgtcggcgac ggatcccgga ctgaggaccc tcggatcggg gtggcgtctg
    20461 gcttgcacag catgaccttg gtcgatgctg tgatcgctca gctagccaac ggtgagcgcc
    20521 ccacggtggg gctctcaccg tgagacgacg gccagcgtca actgcggcag gccggacatc
    20581 tcacccgcgg gcgactactg tgcgcagtag tcgcggtcgg agggagtgac catccatgca
    20641 gcgggtcgtc aggccgcagt ggtggcacga gggcacgttt cgcggcgcgg ccatacgcgt
    20701 acacctcgcg cgtcacgaca tggcggcggc cttcggcttc ctcaaggaac ggggcttcag
    20761 ttggtctgcg atcgcgacgg cgaccgggct gggcgccagc cgggtctcag agatcgcagc
    20821 tgggcgccgc gtcgtcaccg actacgcggt gctggagcgg atcgccgagg ggttgtccat
    20881 cccgcgtcac ttcatggggc ttgctctcga cgaacaggca ctccaccatc ggcggggtga
    20941 cgctcctgag ccggcccgaa gcgctgggcc cctcgacccc cacgagttgc tcggggtcgt
    21001 cgccagcatc gcggtaggag cgatacccga aggcgtggaa cgctggctgc ccaactccca
    21061 gaagaccgcc ctcccggcca ctgtcggtcc ggacgaggta gccaccgttc gcgccgttac
    21121 cgccttccac cgccggctcg atgccgccgc cggaggcggc cggtgcctgc aatccgcgtg
    21181 cggctacgtg gcatgggcga ctcagctcct gcaggtgaag tgcgccgata ccgtcgctgt
    21241 cgacctccgt acagcgcttg ccgaactgca caacctcgtc ggctgggtgg cgcacgactt
    21301 cgacgatcac gacatggccc gccggcacct cacccagagc ctcgtcctcg cgcgacagac
    21361 cgactcgctc ccgctgctgg ccaacacgct gtaccgcctg ggtagggtca gtctccacca
    21421 agggcaaccg gcggaggcgc tccagctgtt cggcctcggt cagctcgccg cacagcaggc
    21481 cgggtgccat gccagcgtcg gcatactgca cgccaactcc gcctgggcct acgccctcct
    21541 cggagccgac caccaggtcg tcgacagcct ttcccgggca cggcgggagc tcgaccgggc
    21601 cgacccggac acggcgcccg cctggaccca cttcgcgctc accgaagccg acggacacgg
    21661 gatctcggcc gtcgtctact ccgccctcgc ccgtcacccg gaacaccttc gatacgtgga
    21721 acgggctgcc gagcactccc atcaggctgt gcagcttcgc cggccccagg accgacgatc
    21781 gttcatcttc gacacgatct ccgtcgccac agcgagtatc cttgccggtg atctcgcaac
    21841 cgctggcgag tacggcacga aggcggtggg gctggtggtg gacgggggaa tgcggtcggc
    21901 ccgtgtcaac gatcgtctgg atgcgctctg ggcgcttgcc gcgcccaagg ccgagcggga
    21961 gccggcgctc gccgctctcg gcagccggct cgcggagctg cgggcggtct gatgaccacc
    22021 gctctcagcg acgctgtcgc ctcggagctc cgtgctcatc tgggcgaggt ctgtgcggag
    22081 ctcggtattg agccggatag cgccaggctc gtgaagtaca cgatgaatgc agttttcgag
    22141 gcgccgccgt tcgtgatccg acttgctgcc ggcccccacg ccttcacgct ggcggaacgc
    22201 gtggtcccgg tcgctcagtg cttggagaag gcggggatgc cgactgtgcg gatctcctcc
    22261 ggcgtcgcct gccgaccgat cttcagcggg gagtgggtcg cgacggcctg gcagtacgtt
    22321 cccacggttc gcgatgagcc caggcctgtc gacctggcca tgccgttgcg cgccctacac
    22381 ggtcttgaac agctcaatgt gccgttgccg cgctggtcgc cgatcccgaa gttccgccgc
    22441 cgtctggacg ccgccgcatc gctaccgcca cgcgaggctg acgacctgga gggatggtcg
    22501 aggactgagt tggggctcag cacccaggat ctgttgcgtg atctccgctg gcgctgcgac
    22561 cgtgccgaag aggatctcga tcgggtggct tggcagttgc ctccgggtgt gatccacggc
    22621 gatgctcaca ccgggaacat cctcctgcct ctgccgggcc aaggggcgag cagtccaaca
    22681 cctctgctct gcgacctgga cggggtgtgc ctcggtccgc gggaatggga tctcgtgccc
    22741 accgcccatg gcgccacccg gttcgggcga tcccggatcg actacgagga tttcgtcgat
    22801 gcctacgggg tggacgtcac cacctggacg ggctggccgg tcctacgagg cgttcgggag
    22861 ctgcaacttg tcacgagcac gattgatgct ctcgctggcc gcccagacgt ggccaagcag
    22921 cttgcccacc gactcaggtc actcttttcc ggtgatctgg aggcgacctg gtgtcgttac
    22981 cggtaagggc ccgaccctac cggtgcccgt gcaggcggca cccgcgtcga cagggccgtc
    23041 ggaacatcag ccgttacaga ctggcccctg acctcgcccg cacctgctcc ggcagatcgt
    23101 ggtcgggcgt gctcccagtt gtcttcgcct gcaattgctc gatggcctct ttcgtgtagt
    23161 cgtccaccag ctttgagagt tgtacatcgt cgagcgattc gaggctgacc aataccgcaa
    23221 gtcgccggag tctgcgcgcg gtgatccgca ggatgtcggt ccttgcggcg ccggcctcac
    23281 cggctacggt caggtggcca tgggcaatgg cgcgggcgac gcgtggatgc gcaccgagcg
    23341 tcgggcgctc gaggatcgcg acggcctcgt cctcgtagag tcgggcgccg aggtcctcgc
    23401 ccaagctgtg gacacgggtc cagaggcgtc ggaacacgtt gcgcggacgg ccgatgatgc
    23461 gttcgtagcc tggccgccgt agtggattgg gccaccgcca gagcgcgatg tccggcaaca
    23521 ggaccaggct gagaaatgac cagacctctt cgctcgccgc gtcggcgggc acgatggtca
    23581 tctgccggta cagggccggt gccagtagcc ggtcgaaggc tgtgccgttc gtcttgccca
    23641 gaggtgccgg ccagttggct tccgcggcga tcccgcggac ggtctgctgc agggcacgga
    23701 ggtcgtcctc cgctacgcgg tggggtgccg tcgggtacca ggtggtgcgc gcatcggcag
    23761 tggccgacag cctgcgcagt tcgacgaggt cccggccggt gtggagggtc agcagccgtt
    23821 ccgcgacgtg ggcaggtaga cgcgggtaga cgtacagccg gttcatgcga ggacccggtc
    23881 gagaccttgg atgaccgcct ccagttcgct cgggtcgttg cggtgttgac tacgtaggtc
    23941 ggagagcgac cggtcgggga agtacctgcg tatcaggttg atgaacagct cgccgagtgt
    24001 gccttcgccg tggtcgtgct cgtcctggag gtcctcgcag cgtagcgccg tctgaatgag
    24061 ctgacggacg acatcgtgcc ggagcacctc ggcgagtgtc ctggaggctt ccgcttccgg
    24121 ctggttgagc atcgtggtga cggcggggtg gtccgagttg aggtacagcc ggatgctgcc
    24181 ggtgtccgac ccgtcgagat ccggggcgca ggagaggtac cacagcgagc ggcgtccctc
    24241 ggcgagccca ctttcggcga agctcgtggc caccacgggg aaccggctgc cgctgccttc
    24301 cagggtgaag cgccgccggg cctgccagag gatggcgccg ggtcggaagg ctgccagcgg
    24361 cgagatcggt gtcgggtcag gtgcagccag gaccatccgg gcggtcaggg tgaggtttcc
    24421 gccgatctcg gtgcccggga tcgcaaccgt cagtcggttt tcaccgtcaa ccagtctggc
    24481 cggggtggaa ttgtcgcggc ggttggtgct gctgctgtgc caggtgacca gacagtgcac
    24541 ggctgcggcg ggcgacaggc cgcagtcctg cagtaccccg ggcaggtcga catgcagggg
    24601 ccagttcgcg gtgagatcgg tgaagtagtc ccagtcaggc accggctccc cctcggggac
    24661 gggtgtgccc tgaggaccgg tgaccgtcac ggttccggat tggatgcgct cctcggccgg
    24721 ggtcaggtgg cccgcactga tcggggcgct cacgtcggtg tcacctcctc ctggcgtatc
    24781 cgcacggtga cggctgcatc agccggttgg gtgagagtga cggtccagtg ttccgacgtc
    24841 tcggtggtca gggtcagttg cggaccgggc gtgaggtctc cgttgtcccg gtcacgccag
    24901 tgcagtactt cgaccggagt ggtctcgtcg gcgggctccg gtgctccgtc agcgatcgcg
    24961 accagtggct gggcgatgag ggtcagcgac gcaccggagg ctccggtgag gtcgatgtcg
    25021 aattcaaccg cacggccgcc gtccctcaac acgatctggc ggggacgggg gtggaaacgc
    25081 agtgtcggac cggtcgtgga gcgcgacccc cgcccgtggt gcctctgctg gcgtcctttg
    25141 cctccgttgt gcactgtcgg tgtgtcgttg tggcctgccg gtgctcccga cgaagtggtc
    25201 ggtggatcgt gcaccgggtt gtccgacccg gccgggatgc ggatgtccgt gccacccgcc
    25261 tgtgtgtcga ggagtgtgcc gaggacgttc gccagccgtg aaacccccgt cgcggcctcg
    25321 gtggtggggg tcgtcgcgtt gtccgtacgg cgttccttga aaatccggtc gatgcggttg
    25381 agtgcctggc tgaccgggtt acgggcgtac cgctgccgtt gcgccagcct cggctgccac
    25441 ctgtcgtgcg tcggtggttc ggcgcgggcg aaatccccgt cgagttcggg atcggcgatg
    25501 aacacgccgc tgatggcgtg cccgaacgga tccggagtga cgttgcggta ctcgacaacg
    25561 aggcccggtc ggcgcatgag ggcgatctcc gcgggtggcc gggcatggct gcctgaggcg
    25621 gccgccctgt acgtccgcca tgccagtacg ccgagacgtt gctccggacg gctgccgacg
    25681 atctcctgga cagcccaggg ccatggatgg tctcctgctg cgccgtcgaa gaccgagcgg
    25741 cagcgccggt gcgcctcgac gaagtaccgc agccgggcat cggtcgccgg gtcgggaaga
    25801 tctatccgtg acccgtcgca ggtgaaccgc aacgtgagcc cgggaggtga ccccacttgc
    25861 ccgacggtgt tggcccacgc gtacctcgtg gcggtgtcgg ccatcacggc gaccacgtcg
    25921 gacaggtgct cctctccggt ccggggagcg atgaccatga ccgaggtgcc ggttgcgtct
    25981 ccggacaggt gcgtcagtcc gatggcccgg gccatgtgct ccgccgccgg gccggtcacc
    26041 ggttccacgc cgacgtcgct gtgtggaact ccccaccagt ggcgtccggt gtactgatgt
    26101 cgcccgaccc ggtagggatc ggtgagtgac atgccgatca gtcggcactc ggtaccggcg
    26161 ctggtcctga tgcgggtgaa tatcaccacg gtgtcgatgc tgctcgcctc gaacagcacg
    26221 gccttgccgt agccgtaggt tccgccaccg aaccccttgt cggggtgtcg gccgatgttc
    26281 cggacgaggt cgacgaaatt ccgtggatca tcctcaccca cccggtccgc cctggtggga
    26341 ccggtgagcc ctttcgtacc ggtgtcggtg accgtgagga ccttgaggcc cgggttgtcc
    26401 aggtcggccc cgggtagaag acgacgcagg ctctgcagtt gcccgggatc gaggggccag
    26461 ccgt
//
