LOCUS       NZ_CP030865            14813 bp    DNA     circular CON 14-AUG-2024
DEFINITION  Micromonospora sp. B006 chromosome, complete genome.
ACCESSION   NZ_CP030865
VERSION     NZ_CP030865.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora sp. B006
  ORGANISM  Micromonospora sp. B006
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 7040153)
  AUTHORS   Braesel,J., Crnkovic,C.M., Kunstman,K.J., Green,S.J.,
            Maienschein-Cline,M., Orjala,J., Murphy,B.T. and Eustaquio,A.S.
  TITLE     Complete Genome of Micromonospora sp. Strain B006 Reveals
            Biosynthetic Potential of a Lake Michigan Actinomycete
  JOURNAL   J Nat Prod 81 (9), 2057-2068 (2018)
   PUBMED   30110167
REFERENCE   2  (bases 1 to 7040153)
  AUTHORS   Braesel,J., Crnkovic,C.M., Kunstman,K.J., Green,S.J.,
            Maienschein-Cline,M., Orjala,J., Murphy,B.T. and Eustaquio,A.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2018) Medicinal Chemistry and Pharmacognosy,
            University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL
            60607, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5.0
            Expected Final Version            :: yes
            Genome Coverage                   :: 77.6x
            Sequencing Technology :: Illumina; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003408515.1-RS_2024_08_14
            Annotation Date                   :: 08/14/2024 03:31:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,342
            CDSs (total)                      :: 6,278
            Genes (coding)                    :: 6,199
            CDSs (with protein)               :: 6,199
            Genes (RNA)                       :: 64
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 20 of 79
            Pseudo Genes (incomplete)         :: 62 of 79
            Pseudo Genes (internal stop)      :: 6 of 79
            Pseudo Genes (multiple problems)  :: 7 of 79
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:07:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 957074
            Orig. end                         :: 971887
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030865.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..14813
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NAGGN"
                     /region_number="3"
                     /rules="((TIGR03104 or cds(GATase_7 and Asn_synthase)) and
                     TIGR03103 and (TIGR03106 or Peptidase_M42))"
                     /tool="antismash"
     cand_cluster    1..14813
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /kind="single"
                     /product="NAGGN"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..14813
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9813](-)"
                     /cutoff="10000"
                     /detection_rule="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /neighbourhood="5000"
                     /product="NAGGN"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..9813)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /neighbourhood="5000"
                     /product="NAGGN"
                     /protocluster_number="1"
     gene            complement(177..1223)
                     /locus_tag="MicB006_RS04745"
                     /old_locus_tag="MicB006_0962"
     CDS             complement(177..1223)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787506.1"
                     /locus_tag="MicB006_RS04745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0962"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_116504077.1"
                     /transl_table=11
                     /translation="MGDAGSVAPVRWQRARHIARLAAIGTGATVAATAATGGVLLGQAR
                     QARRTIPMAQAPPPRCDGVYGARLPGPPVTVVVLGDSSAAGYGVHRRRETPGSLLATGL
                     SRRLHRPVRLHRFAVVGALSSGLKPQVESALEVEPDVAVILVGGNDVTNRTPPALAVRY
                     LVDAVRTLRAAGCEVVVGTCPDLGTIRPIQPPLRWLARRWSRQLAAAQTVAVVEAGGRT
                     VSLGDMLGPRFAAEPGRMFAWDRFHPSAEGYAIAAAAVLPTVLSALGAVPERRPVLPGV
                     EGVRSLPEAAHEAARHAGTEVSGAQLRGRDRGPGGRWAQLRRRAFFGVGALPPTGSAAD
                     SATLEETA"
     gene            1365..1721
                     /locus_tag="MicB006_RS04750"
                     /old_locus_tag="MicB006_0963"
     CDS             1365..1721
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007074683.1"
                     /locus_tag="MicB006_RS04750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0963"
                     /product="YkvA family protein"
                     /protein_id="WP_013474058.1"
                     /transl_table=11
                     /translation="MGKTLKRSAAFAALARALAAGTRGGPSLGARLAALPRMIRATTRG
                     EYDGGLRLALMAGATAYIVSPIDLLPEIPLAIFGLADDAVMVTWLAGSVLAETERFLEW
                     EARRSSVIPGHVVP"
     gene            1798..3168
                     /locus_tag="MicB006_RS04755"
                     /old_locus_tag="MicB006_0964"
     CDS             1798..3168
                     /EC_number="4.2.1.22"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004122 - cystathionine beta-synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019343 - cysteine biosynthetic process via
                     cystathionine [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018742048.1"
                     /locus_tag="MicB006_RS04755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0964"
                     /product="cystathionine beta-synthase"
                     /protein_id="WP_073824917.1"
                     /sec_met_domain="PALP (E-value: 8.8e-72, bitscore: 240.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYYDNVVELIGNTPLVRLRNVTEGIQATVLAKVEYVNPGGSVKD
                     RIALRMVEDAEKAGILRPGGTIVEPTSGNTGVGLALVAQLRGYRCVFVCPDKVSQDKQD
                     VLRAYGAEVVVCPTAVAPEDPRSYYNVSDRLAREIPGAWKPNQYSNPANPRSHYETTGP
                     ELWKQTEGRITHFVAGVGTGGTISGIGRYLKEASEGRVKVIGADPEGSVYSGGTGRPYL
                     VEGVGEDFWPETYDRSVADEIVEVSDKESFEMTRRLAREEGLLVGGSCGMAVVGALEVA
                     RKAGPDDVIVVLLPDGGRGYLSKIFNDKWMARYGFLDDSGTEPTVADALAGKPGGLPEL
                     VHVHPTETVRDAIDYMREYGVSQLPVLKAEPPVVTGEVAGSIAEKDLLDALFTGQAHLH
                     DTIERHMGEPLPMIGGGQPVSEAVGLLEKADAALVLVDGKPKGVLTRQDLLAHLGAR"
     misc_feature    complement(1825..1838)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            complement(3259..3768)
                     /locus_tag="MicB006_RS04760"
                     /old_locus_tag="MicB006_0965"
     CDS             complement(3259..3768)
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018742049.1"
                     /locus_tag="MicB006_RS04760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0965"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_116504079.1"
                     /transl_table=11
                     /translation="MTISLRSATEADLMAVGAMHQRSRVAAYSSFLPPETLADPTPEAM
                     GRYWVERLTWEGADHRMTVAERDGRLVGFSYLGPDDEGDPATGLLNAIHLEPSERGRGT
                     GRALMVDALDAMRARGWTRAALWVLRDNAAARRFYERGGWAATGEQRNEHIGAALVPQL
                     RYARQV"
     gene            complement(3765..4694)
                     /locus_tag="MicB006_RS04765"
                     /old_locus_tag="MicB006_0966"
     CDS             complement(3765..4694)
                     /EC_number="3.1.26.11"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018586560.1"
                     /locus_tag="MicB006_RS04765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0966"
                     /product="ribonuclease Z"
                     /protein_id="WP_116504080.1"
                     /transl_table=11
                     /translation="MSMRELVVLGTASQAPTRQRNHNGYLLRWDDEVILFDPGEGSQRQ
                     MLHTGVTATDLTRICVTHFHGDHCLGLPGMIQRLSLDRVPHPVAVHFPAGGAEYFARLR
                     HASSFYETAELAVEPIDADGQRITLGVGTLEARRLRHPIETYGYRLVEPDGCRMLPERL
                     AAYGIAGPDVGRLLRDGHLDRDGRRVTRDEVSVTRPGQRFAFVMDTGLCDGVYALAEHA
                     DLLVIESTFLESEAALAAEVGHLTAGQAARVAAESGVRTLVLTHFSQRYADPRRFHDEA
                     REHFTGDLVIAEDLLTVPVPPRRVPSPG"
     misc_feature    4917..4932
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.95"
                     /tool="antismash"
     gene            complement(5001..6185)
                     /locus_tag="MicB006_RS04770"
                     /old_locus_tag="MicB006_0967"
     CDS             complement(5001..6185)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03106"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     Peptidase_M42"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787511.1"
                     /locus_tag="MicB006_RS04770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0967"
                     /product="osmoprotectant NAGGN system M42 family peptidase"
                     /protein_id="WP_091418524.1"
                     /sec_met_domain="TIGR03106 (E-value: 2.1e-146, bitscore:
                     485.6, seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_M42 (E-value: 3.1e-56, bitscore:
                     189.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARKPQPLKLDLDYLRQVLVELLEIPSPSGRTDHIQQYVGERLS
                     AIGISSTLTRRGALSACLPGPRSTGADRAIVVHTDTIGGMVKRLKENGRLEVNPIGTHS
                     ARFAEGAHVRIFTDDLERVVTGQVLPLKASGHRYNEAVDLQGVGWELVEVRVDEPVHDE
                     AGLRALGIDAGDFVAFLPNPTITPNGYVKSRHLDDKAGVAAVLTAFKAMVEAGVTPAVT
                     AHLLVTVTEEIGHGASHGLDPDVAEIVSVDAAVVAPGQQSRETAATLAMGDGVGPFDYH
                     LTRNLASIAKEHGVDLVRDVFDYYRSDVAAAVEAGAHARVALLGFGVDATHGHERTHLD
                     GLHQLTQLLCLYLQSPLVFPEWDAEPEGDLADFPSLAVQPANEEGPREGPIGLD"
     gene            complement(6182..8020)
                     /gene="ngg"
                     /locus_tag="MicB006_RS04775"
                     /old_locus_tag="MicB006_0968"
     CDS             complement(6182..8020)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ngg"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03103"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018810760.1"
                     /locus_tag="MicB006_RS04775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0968"
                     /product="N-acetylglutaminylglutamine synthetase"
                     /protein_id="WP_116504082.1"
                     /sec_met_domain="TIGR03103 (E-value: 1e-238, bitscore:
                     791.7, seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 2.4e-07, bitscore: 29.1,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 5.6e-07,
                     bitscore: 27.8, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTLATGTARTDRERVLGRRRERIGPGGDPVAPGTPEPRQPETA
                     STDASGVVLDCGWGRLVFGQTFDDQVHVADVLRSEAVGARDICIYLRDPHVLVSRLPDE
                     LFIDPSLTYRLPLGEKRPAATEGGEVPGLTVRPLRDAADAEAVNRIYARNGMVTAPVEV
                     LVDNAGTDRFLHLVAEDTTGEVVGTITGVDHVAVFGDPENGASLWCLTVDFNTAPPGTG
                     QALLTALADRLDGRGRAFVDLSVLAENSGAIRLYERLGFHRTGTLCVKRKNPINERLFL
                     PAMPQGYDELNPYAKIVADEAMRRGIRVEVTDPHWGELKLTTGGRTIHTRESLSELTSA
                     VAMSRCDDKRVTRRILTEAGLSVPRGRTATGEPDDVAFLNDVGPVVVKPARGEQGNGIT
                     VGVRTPEALTAAVELARRFCPDVLIEELRAGEDLRVVVIDHEVVAAAVRRPAQITGDGV
                     HDITELIERQSRRRAAATGGESRIPVDDMTREVVAEAGYRMHDVLPEGEVLAVRRTANL
                     HTGGTIHDVTAELHPAIAEACVTASRALDIPVTGLDLLVPAPDRPEHVFIEANERPGLA
                     NHEPQPTAERFVDLLFPGTRAPQRLWSPAGAAGSGA"
     gene            complement(8023..9813)
                     /locus_tag="MicB006_RS04780"
                     /old_locus_tag="MicB006_0969"
     CDS             complement(8023..9813)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     Asn_synthase"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03104"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007074689.1"
                     /locus_tag="MicB006_RS04780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0969"
                     /product="N-acetylglutaminylglutamine amidotransferase"
                     /protein_id="WP_116504084.1"
                     /sec_met_domain="TIGR03104 (E-value: 5.6e-286, bitscore:
                     947.9, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="GATase_7 (E-value: 3.9e-40, bitscore:
                     135.1, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.4e-86, bitscore:
                     289.9, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGLAGEFRRDGSRADVSAVERMAATMSDRGPDDSGVWSQGPTAL
                     GHRRLKIIDLSAASGQPIVDAAAGLTGVFNGCIYNYRELRAELQAKGHRFFSSGDSEVV
                     VKAYAEWGLDFVDHLIGMFAVAISERDTGRLVLARDRLGIKPLYLAESPGVVRFASTLP
                     ALVAGGGIDTTIDRVALAHYLSFHSIVPPPRTILAGVTKLPPATVRVYEADGSSHERVY
                     WDPSFGRAAERAGWSERDWQDALLDSLTTAVRRRMVADVPVGVLLSGGLDSSLVVALLA
                     GEGQVQSGLATFSIGFDAVGGREGDEFVYSDLVAKTFGTDHHQIRVPTGDLLPPLEAAV
                     AAMSEPMVSHDCVAFWLLSQEVAKHVKVVQSGQGADEILGGYHWYPPLAGVDREQALDT
                     YAKAFFDRDAAGLARVLNPAWLADGDPAREFVAAHLGRPGAQTAVDAGLRIDTQVMLTD
                     DPVKRVDNMTMAHGLEARVPFLDHEFVELAASCPPELKLAQGGKGVLKEIGRRVLPHEV
                     IDRPKGYFPVPGLTHLEGKLLDRVRDALTSPEARRRDLFRADYVDALLADPNAELTPLN
                     GNKLWQLGLLEMWLQSHGID"
     misc_feature    complement(9844..9858)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
     misc_feature    complement(9895..9908)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.26"
                     /tool="antismash"
     misc_feature    complement(9986..9999)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            complement(10096..10758)
                     /gene="msrA"
                     /locus_tag="MicB006_RS04785"
                     /old_locus_tag="MicB006_0970"
     CDS             complement(10096..10758)
                     /EC_number="1.8.4.11"
                     /GO_function="GO:0008113 - peptide-methionine (S)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_function="GO:0033744 -
                     L-methionine:thioredoxin-disulfide S-oxidoreductase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020215983.1"
                     /locus_tag="MicB006_RS04785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0970"
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="WP_116504086.1"
                     /transl_table=11
                     /translation="MFLRRMKAEMISPDQALPGRPIAMPIADRHEVLPSTLKGPFPEGA
                     QVAVFGMGCFWGAERLFWTLPGMITTSAGYAGGYTTNPTYEEVCSGMTGHAEVVQVVYD
                     PSKIAYEDLLKVFWENHDPTQGMRQGNDVGTQYRSAIYTTTDEQAAAAKASRDAFAPIV
                     ARAGKGEITTEIAPLGDYYFAEDYHQQYLAPTKNPNGYCNHGPNGLSCPVGVARTAG"
     gene            complement(10833..11246)
                     /locus_tag="MicB006_RS04790"
                     /old_locus_tag="MicB006_0971"
     CDS             complement(10833..11246)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013474065.1"
                     /locus_tag="MicB006_RS04790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0971"
                     /product="HIT family protein"
                     /protein_id="WP_073824903.1"
                     /transl_table=11
                     /translation="MSGCVFCGIVAGEVPAFRVTDEPDGVAFLDTRPVFKGHVLVVPRT
                     HLVTLADLPADALPGYFRLVQRIAVAVETGLGSGGTFVAMNNRVSQSVPHLHTHVVPRT
                     KGDGLRGFFWPRTRYADDAEAEAFAGRISAALA"
     gene            complement(11311..11988)
                     /locus_tag="MicB006_RS04795"
                     /old_locus_tag="MicB006_0972"
     CDS             complement(11311..11988)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020419.4"
                     /locus_tag="MicB006_RS04795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0972"
                     /product="nucleotidyl transferase AbiEii/AbiGii toxin
                     family protein"
                     /protein_id="WP_161565909.1"
                     /transl_table=11
                     /translation="MRLLRVGFRAGDDLGLVLAGGYALAAHDLVHRQSRDIDFATATAL
                     PLPLVAARLTDVYRAEGLDCRVVEATPRMARLLVEGPDFACEIDLLKEAIGPPARLHIG
                     PVLALEDAIGLKVRALHDRAAHRDYIDVRAAGRIVEYRALESLGARHTVAFSLHELADR
                     LGGIDELEVETFASYGLGEDDIDGLRRWARRWETDIRARLANGETGPSGVPEDDWDTYL
                     DRS"
     gene            complement(12006..12332)
                     /locus_tag="MicB006_RS04800"
                     /old_locus_tag="MicB006_0973"
     CDS             complement(12006..12332)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787517.1"
                     /locus_tag="MicB006_RS04800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0973"
                     /product="hypothetical protein"
                     /protein_id="WP_116504090.1"
                     /transl_table=11
                     /translation="MSTTEALPSRLHGVADRIPTSLDELKGPEHGRVTLPTRLAWSGLT
                     EFDVDDSGQRLTLYRTLMDCGQREDIVRYVNPALLRQDWSRICKLTARRVIRIWENRMP
                     GLTA"
     gene            12428..13570
                     /locus_tag="MicB006_RS04805"
                     /old_locus_tag="MicB006_0974"
     CDS             12428..13570
                     /EC_number="2.5.1.48"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (47-186). E-value:
                     6.6e-09. Score: 27.3. Matches aSDomain:
                     nrpspksdomains_MicB006_RS04805_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011904831.1"
                     /locus_tag="MicB006_RS04805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="MicB006_0974"
                     /product="cystathionine gamma-synthase"
                     /protein_id="WP_073824892.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 6.9e-07, bitscore:
                     27.3, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 7.8e-07,
                     bitscore: 27.2, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.3e-05, bitscore:
                     22.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHGFETLAIHAGQAPEARTGAVIPPIYQTSTYAQDAVGAPREGY
                     EYSRSGNPTRDALQECLAALEGGQVGLAFASGLAAEDTLLRTVCKPGDHVVIPDDAYGG
                     TYRLFAKVAERWGLTYTPAKVSDPDAVRAAIRPGATRIVWVETPTNPLLGIADIAALAA
                     VAHDAGALLVVDNTFASPYLQQPIAFGADVVVHSTTKYVGGHSDVVGGALVSADRALGE
                     ELRYHQNAMGAINGPFDAWLTLRGIKTLGVRMDRHCDNAERIAAYLDGNAKVAQVIYPG
                     LPSHPGHEVAAKQMRRFGGMISFRAAGGEEHAVEICNRARLFVLAESLGGVESLIEHPG
                     RMTHASAAGSPLEVPGDLVRLSVGIETVDDLLADLEQALG"
     aSDomain        12569..12985
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_MicB006_RS04805_Aminotran_1_2.1"
                     /evalue="6.60E-09"
                     /label="MicB006_RS04805_Aminotran_1_2.1"
                     /locus_tag="MicB006_RS04805"
                     /protein_end="186"
                     /protein_start="47"
                     /score="27.3"
                     /tool="antismash"
                     /translation="SRSGNPTRDALQECLAALEGGQVGLAFASGLAAEDTLLRTVCKPG
                     DHVVIPDDAYGGTYRLFAKVAERWGLTYTPAKVSDPDAVRAAIRPGATRIVWVETPTNP
                     LLGIADIAALAAVAHDAGALLVVDNTFASPYLQQP"
     misc_feature    14577..14590
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.88"
                     /tool="antismash"
ORIGIN
        1 gcctcaccgc gctcgctcat gaccgcactc cgcttcgctc cgtgccgcca cgaggcacct
       61 ctgcgctgag ctggctgatt cgctcgctgc gctcgctcat gacagcactc cgcttcgctc
      121 cgtgccgcca tgaggcacct ctgcgctgag ctggctgatt cgctcgcttc gctcgctcat
      181 gccgtttcct ccagggtggc cgagtcggcg gcgctgccgg tcgggggtag cgcgccgacg
      241 ccgaagaagg cccgtcggcg aagctgcgcc cagcggccgc cgggcccgcg gtcgcggccc
      301 cggagctggg cgccgctgac ctccgtaccg gcgtgccggg ccgcctcgtg agccgcctcc
      361 gggagcgacc gtacgccttc cacgccgggc aggacaggcc tgcgctccgg gacggcgccc
      421 agcgcggaca gcacggtggg cagcacggcc gccgcggcga tcgcgtaccc ctcggcggag
      481 ggatggaacc ggtcccaggc gaacatccgg ccgggctcgg cggcgaaccg tggcccgagc
      541 atgtcgccga gcgagacggt acggccaccg gcctccacca cggccaccgt ctgggcggcg
      601 gcgagctggc ggctccagcg ccgggccagc cagcgcagcg gcggctggat cggccggatg
      661 gtgcccaggt cgggacaggt gccgacgacc acctcacagc cggccgcccg cagcgtgcgg
      721 accgcgtcga ccaggtaacg cactgccagc gccggcggcg tgcggttggt gacgtcgttg
      781 ccgcccacca ggatcaccgc cacgtccggc tcgacctcca gggcggactc gacctgcggc
      841 ttcagcccgg acgacagcgc gcccaccacg gcgaaccggt gcaggcgtac cggccggtgc
      901 aggcggcggg acagcccggt ggccagcagc gagccggggg tctcccggcg cctgtgcacg
      961 ccgtagccgg ccgccgagga atcgcccagg acgaccacgg tgaccggcgg gccgggcagc
     1021 ctcgcgccgt agacgccgtc gcagcgcggc ggcggggcct gcgccatcgg gatggtgcgg
     1081 cgggcctgcc gggcctgacc gagcagcacc ccgccggtgg cggcggtggc cgccaccgtg
     1141 gcgcccgtgc cgatcgccgc gaggcgggcg atgtgccggg cgcgctgcca gcggaccggc
     1201 gcgacggaac cagcgtcccc catgaaccga cagtatcgcg ccggtacgac ccccactgtc
     1261 cgcgatcgga tggctgggcg gtgcccggat tgggtaccga tgggggtagc gggcgcgggc
     1321 ttgccaccgg gccgcaccat ggtcgggcgg agaggggcga aaacatgggg aagacgttga
     1381 agcgcagcgc cgcgttcgcc gcgctggccc gggcgctggc ggcgggtacg cggggcgggc
     1441 cgtcgctcgg ggcccggctg gcggcgctgc cgcggatgat ccgcgcgacc acccggggcg
     1501 agtacgacgg cggcctgcgc ctggcgctga tggccggggc gaccgcgtac atcgtcagtc
     1561 cgatcgacct gctgccggag atcccgctgg cgatcttcgg gctggccgac gacgcggtga
     1621 tggtcacctg gctggccggc agcgtgctcg ccgagaccga gcggttcctg gagtgggagg
     1681 cacgtcgcag ctcggtcatc ccggggcatg tggtgccctg acggcacgta cgctggtcgg
     1741 cgaactgacg gctgaccgac cgccccacga cggcggcgcg acgaagggca caacgaggtg
     1801 cagtactacg acaacgtcgt cgagttgatc ggcaacaccc cgctggtccg cctgcgcaac
     1861 gtcaccgagg gcattcaggc caccgtgctg gcgaaggtgg agtacgtcaa cccgggcggc
     1921 tcggtcaagg accggatcgc gctgcggatg gtggaggacg ccgagaaggc ggggatcctg
     1981 cggccgggcg gcacgatcgt ggagccgacc agcggcaaca ccggcgtcgg gctggccctg
     2041 gtggcccagc tccggggcta ccggtgcgtc ttcgtctgcc cggacaaggt cagccaggac
     2101 aagcaggacg tgctgcgcgc gtacggcgcg gaggtggtgg tctgcccgac cgccgtcgcg
     2161 ccggaggacc cgcgctccta ctacaacgtc tccgaccggc tggcccggga gatccccggc
     2221 gcgtggaagc ccaaccagta cagcaacccg gccaacccgc gctcgcacta cgagaccacc
     2281 ggcccggagc tgtggaagca gaccgagggc aggatcaccc acttcgtcgc gggcgtcggc
     2341 accggcggca ccatctccgg catcggccgc tacctcaagg aggcgtccga gggccgggtg
     2401 aaggtgatcg gcgcggaccc ggagggctcg gtctactccg gcggcaccgg ccggccgtac
     2461 ctggtcgagg gcgtcggtga ggacttctgg ccggagacgt acgaccggtc ggtcgccgac
     2521 gagatcgtcg aggtgtcgga caaggagtcg ttcgagatga cccgccggct ggcccgcgag
     2581 gagggtctgc tggtcggcgg ctcctgcggc atggcggtgg tgggcgcgct ggaggtggcc
     2641 cgcaaggccg gcccggacga cgtgatcgtg gtgctgctgc cggacggcgg ccgcggctac
     2701 ctgtcgaaga tcttcaacga caagtggatg gcccggtacg gcttcctgga cgactccggc
     2761 accgagccga cggtggccga cgcgctcgcc ggcaagcccg gcggcctgcc cgagctggtg
     2821 cacgtgcacc cgaccgagac ggtccgcgac gcgatcgact acatgcgcga gtacggcgtc
     2881 tcgcagcttc cggtgctgaa ggccgagccg ccggtggtga ccggtgaggt ggccggttcg
     2941 atcgcggaaa aggacctgct cgacgcgctc ttcaccggcc aggcccacct gcacgacacg
     3001 atcgagcggc acatgggcga gccgctgccg atgatcggcg gcgggcagcc ggtgagcgag
     3061 gcggtcgggc tgctggagaa ggcggacgcg gcgctggtgc tggtcgacgg caagcccaag
     3121 ggcgtgctga cccgccagga tctgctcgcc cacctcggag cccgctgacc ctgcgcgtgc
     3181 aaggaagggc cccttattaa cacgtggtgt taataagggg cccttcctct accggaggcg
     3241 ttaatagggg gcccttcctt acacctggcg ggcgtagcgg agctggggga cgagcgccgc
     3301 gccgatgtgc tcgttccgct gctcaccggt ggcggcccag ccgccgcgct cgtagaagcg
     3361 gcgcgcggcg gcgttgtccc gcagcaccca caacgccgcc cgggtccacc cgcgggcccg
     3421 catcgcgtcc agcgcgtcca ccatcagcgc ccgcccggtg ccccgccccc gctcggacgg
     3481 ctccaggtgg atcgcgttca gcagcccggt cgccgggtcg ccctcgtcgt ccggcccgag
     3541 gtagctgaac cccaccagcc gcccgtcccg ctcggccact gtcatccggt ggtcggcgcc
     3601 ctcccaggtc agccgctcca cccagtagcg gcccatcgcc tcgggcgtcg ggtcggccag
     3661 cgtttcgggc ggcaggaacg acgagtacgc cgccacccgt gagcgctggt gcatggcgcc
     3721 gaccgccatc aggtcggcct cggtcgcgga acgtagggag atcgtcaccc gggcgacggt
     3781 acccgccggg gcggcaccgg aaccgtcagc agatcctcgg cgatcaccag atcaccggtg
     3841 aagtgttccc gggcctcgtc gtggaagcgg cgcgggtcgg cgtaccgctg ggagaagtgg
     3901 gtgagcacga gcgtgcgtac ccccgactcg gccgccaccc gcgcggcctg gccggcggtg
     3961 aggtgcccga cctcggcggc gagcgcggcc tccgactcca ggaacgtcga ctcgatcacc
     4021 agcaggtcgg cgtgctcggc cagcgcgtac accccgtcgc agagcccggt gtccatcacg
     4081 aacgcgaacc gctgcccggg ccgggtcacg ctcacctcgt cccgggtgac gcggcgcccg
     4141 tcgcggtcca ggtggccgtc gcgcagcagc cgccccacat ccggaccggc gatcccgtac
     4201 gcggccagcc gctccggaag catccggcag ccgtccggct cgaccaggcg gtatccgtac
     4261 gtctcgatcg ggtgccgcag ccggcgggcc tccagcgtgc cgacgccgag cgtgatccgc
     4321 tgcccgtcgg cgtcgatcgg ctcgacggcg agttcggcgg tctcgtagaa gctggaggcg
     4381 tggcgcagcc gggcgaagta ctcggcgcca ccggccggga agtgcacagc caccgggtgc
     4441 ggtacgcggt ccagcgagag ccgctggatc atgccgggca ggccgaggca gtggtcgccg
     4501 tggaagtggg tgacgcagat ccgggtcagg tcggtggctg tgacaccggt gtgcagcatc
     4561 tgccgctggc tgccctcgcc cgggtcgaag aggatcacct cgtcgtccca gcgcagcagg
     4621 tagccgttgt ggttgcgctg ccgggtcggg gcctggctgg ccgtaccgag caccaccagc
     4681 tcacgcatgg acacggcatc ctccggaagg caaaaagcga cccccggggc ttccgcgctc
     4741 gcgcgcgggc cggctggact gggccggcac cccgggggtc gggtggctgt cgtggtttcg
     4801 ccgcaccgct gccacacggt ctcgacgatc ctgcaggtgc ccgcctcgcg gcggacgagt
     4861 tttgactgtc gaggacagcg gctagcggac agccacctca cgagtccgat tgctatacaa
     4921 gtctggacca cctcctttcc cgtgtaccgc cacgctatcc acttcccggc ggccgcggca
     4981 acggatttcg atcacaggcg tcagtccagg ccgatcgggc cctcgcgcgg gccctcctcg
     5041 ttcgccggct gcactgccag cgacgggaag tcggccaggt cgccctccgg ctcggcgtcc
     5101 cactcgggga acaccagcgg gctctgcagg tagaggcaga gcagctgggt gagctggtgc
     5161 aggccgtcca ggtgggtgcg ctcgtggccg tgggtggcgt ccacgccgaa gccgaggagc
     5221 gccacccggg cgtgcgcccc ggcctcgacc gcggcggcca cgtccgagcg gtagtagtcg
     5281 aagacgtccc ggaccaggtc gacgccgtgt tccttggcga tcgaggcgag gttgcgggtc
     5341 aggtggtagt cgaacggccc gaccccgtcg cccatggcga gcgtcgcagc ggtctcccgg
     5401 gactgctggc ccggcgcgac caccgccgcg tcgaccgaga cgatctccgc gacgtccggg
     5461 tccagcccgt ggctggcgcc gtggccgatc tcctcggtga cggtgaccag caggtgcgcg
     5521 gtgacagccg gggtgacccc ggcctcgacc atcgccttga acgcggtcag caccgccgcc
     5581 acgcccgcct tgtcgtccag gtggcgggac ttgacgtacc cgttcggggt gatggtcggg
     5641 ttgggcagga acgccacgaa gtcgccggcg tcgatgccga gcgcccgcag cccggcctcg
     5701 tcgtgcaccg gctcgtccac ccgcacctcg accagctccc agccgacgcc ctggaggtcg
     5761 accgcctcgt tgtagcggtg gccgctcgcc ttcagcggca gcacctggcc ggtgacgacc
     5821 cgctccaggt cgtcggtgaa gatccgcacg tgggcgccct cggcgaagcg ggcgctgtgc
     5881 gtaccgatcg ggttgacctc cagccggccg ttctccttca gccgcttcac catgccgccg
     5941 atggtgtcgg tgtgcaccac gatcgcccgg tcggcgccgg tcgaccgggg gccgggcaga
     6001 caggcgctca gcgccccgcg acgggtcagc gtggagctga tcccgatcgc ggagagccgc
     6061 tcgcccacgt actgctggat gtggtcggtg cgccccgacg ggctggggat ctccagcagc
     6121 tccaccagca cctggcggag atagtcgagg tcgagcttga gcggttgggg tttgcgtgcg
     6181 gtcatgcccc agagcctgcc gcaccggcag gcgaccagag tcgctgcggt gcccgggtac
     6241 ccgggaagag caggtcgacg aaacgttcgg cggtcggctg cggctcgtgg ttggccagtc
     6301 cgggccgctc gttcgcctcg atgaacacgt gttccggccg gtccggggcg gggaccagca
     6361 ggtccagccc ggtgaccggg atgtccagcg cccggctggc ggtgacgcac gcctcggcga
     6421 tcgccgggtg cagctcggcg gtcacgtcgt ggatcgtgcc gccggtgtgc aggttggccg
     6481 tccgccggac cgccagcacc tcgccctccg ggagcacgtc gtgcatccgg tagccggcct
     6541 cggccaccac ctcgcgggtc atgtcgtcga ccgggatgcg ggactcgccg ccggtggcgg
     6601 ccgcccggcg gcggctctgc cgctcgatca gctcggtgat gtcgtgcacg ccgtcgccgg
     6661 tgatctgcgc cgggcggcgt accgcggcgg cgaccacctc gtggtcgatc accacgaccc
     6721 gcaggtcctc gcccgcgcgc agctcctcga tcagcacgtc cgggcagaac cggcgggcca
     6781 gctcgacggc cgcggtcagc gcctccggcg tacgcacgcc gacggtgatg ccgttgccct
     6841 gctcgccgcg cgccggcttg accaccaccg ggcccacgtc gttgaggaac gccacgtcgt
     6901 cgggctcgcc ggtggcggtg cgcccgcgtg gcacggacag cccggcctcg gtgaggatgc
     6961 gccgggtcac ccgcttgtcg tcgcagcggc tcatcgccac cgccgaggtc agctcggaca
     7021 gcgactcgcg ggtgtggatg gtcctgccgc cggtggtcag cttcagctca ccccagtgcg
     7081 ggtcggtcac ctccacccgg atgccgcggc gcatcgcctc gtccgcgacg atcttcgcgt
     7141 acgggttcag ctcgtcgtac ccctgcggca tggcgggcag gaacaggcgc tcgttgatcg
     7201 ggttcttccg cttcacgcag agcgtgccgg tgcggtggaa gccgaggcgc tcgtacagcc
     7261 ggatcgcgcc cgagttctcg gccagcacgg acaggtccac gaacgcccgg ccgcgcccgt
     7321 cgagccggtc ggcgagcgcg gtgagcagcg cctggccggt gccgggcggg gcggtgttga
     7381 agtccacggt caggcaccac aggctggcac cgttctccgg gtcgccgaag accgcgacgt
     7441 ggtccacgcc ggtgatggtg ccgaccacct cacctgtggt gtcctcggcc accaggtgca
     7501 ggaaccggtc cgtgccggcg ttgtccacga gcacctcgac cggggcggtg accatgccgt
     7561 tgcgggcgta gatccggttc accgcctccg cgtcggcggc gtcgcgcagc ggccggacgg
     7621 tcagcccggg cacctcgcca ccctcggtgg cggcgggccg cttctcgccc agcggcagcc
     7681 ggtacgtcag cgacgggtcg atgaacagct cgtccggcag ccgggacacc agcacgtgcg
     7741 ggtcgcgcag gtagatgcag atgtcccggg cgccgaccgc ctcggagcgc agcacgtctg
     7801 ccacgtgcac ctggtcgtcg aacgtctgcc cgaacaccag ccggccccag ccgcagtcca
     7861 gcaccacgcc cgaggcgtcg gtggacgcgg tctccggctg ccgcggctcc ggcgtacccg
     7921 gtgcgaccgg gtcaccgccg gggccgatgc gttcccggcg gcgccccagc acccgttccc
     7981 ggtcggtacg cgccgttccg gtggcgaggg tgtcggtcac tgtcagtcga ttccgtggct
     8041 ctggagccac atttccagga gtcccagttg ccacagcttg tttccgttca acggggtcag
     8101 ttcggcattc gggtcggcga gcagcgcgtc gacgtagtcg gcgcggaaca ggtcccgacg
     8161 gcgcgcctcc ggcgaggtga gcgcgtcgcg tacccggtcg aggagcttgc cctccaggtg
     8221 ggtgagaccg ggcaccggga agtagccctt gggccggtcg atgacctcgt gcggcaggac
     8281 ccggcgaccg atctccttga gcacgccctt gccgccctgg gccagcttca gctccggcgg
     8341 gcagctcgcg gcgagttcga cgaactcgtg gtcgaggaac ggcacccggg cctccagccc
     8401 gtgcgccatg gtcatgttgt cgacccgctt caccgggtcg tcggtcagca tgacctgggt
     8461 gtcgatccgc aggccggcgt cgacggcggt ctgcgcgccc gggcggccca ggtgcgcggc
     8521 cacgaactcc cgcgccgggt cgccgtcggc cagccacgcc gggttgagca cccgggccag
     8581 tccggccgcg tcgcggtcga agaacgcctt cgcgtacgta tcgagcgcct gctcccggtc
     8641 caccccggcg agcggcgggt accagtggta gccgcccagg atctcgtccg cgccctggcc
     8701 cgactgcacc accttgacgt gcttcgcgac ctcctggctg agcagccaga acgcgacgca
     8761 gtcgtggctg accatgggct cgctcatggc cgcgacggcg gcctccagcg gcggcagcag
     8821 gtcgccggtg ggcacccgga tctggtggtg gtcggtgccg aacgtcttcg cgaccaggtc
     8881 ggagtagacg aactcgtcac cctcccgccc gcccaccgcg tcgaagccga tggagaacgt
     8941 ggccaggccg gactgcacct gcccctcgcc tgcgagcagc gcgacgacca ggctggagtc
     9001 gaggccgccg gagagcagca cgcccaccgg gacgtcggcc accatacggc ggcgtacggc
     9061 ggtggtcagc gagtcgagca gcgcgtcctg ccagtcccgc tcggaccagc cggcccgctc
     9121 ggcggcgcgg ccgaacgacg gatcccagta cacccgctcg tggctggagc cgtccgcctc
     9181 gtacacccgg accgtggccg gcggcagctt ggtgacgccg gcgaggatgg tgcgcggcgg
     9241 cggcacgatg ctgtggaagc tcaggtagtg ggcgagcgcc acccggtcga tggtggtgtc
     9301 gatgccgcca ccggcgacca gcgccggcag ggtcgaggcg aaccgcacca cgccggggct
     9361 ctcggccagg tagagcggct tgatgccgag gcggtcgcgg gccagcacca ggcggccggt
     9421 gtcgcgctcg ctgatcgcca ccgcgaacat gccgatgagg tggtcgacga agtcgagacc
     9481 ccactcggcg tacgccttga ccacgacctc gctgtctccg gaggagaaga agcggtggcc
     9541 cttggcctgc agctccgcgc gcagctcccg gtagttgtag atgcagccgt tgaacacgcc
     9601 ggtgagcccg gcggccgcgt ccacgatcgg ttggccgctc gcggcggaca agtcgatgat
     9661 cttcaggcgc cggtgtccca gcgcggtcgg cccctgcgac cagacgccgc tgtcgtcggg
     9721 ccctcggtca ctcatcgtgg ccgccatccg ctccacggcc gagacatcgg cgcgtgaacc
     9781 gtcacggcgg aactctcccg caagtccgca catacgagcc aatgctgcca gaggttgttt
     9841 cggttcgcct gttgagacga tgacgaacgt gtgacagctt gctacgatgc gccgtcacgc
     9901 agggtggccg cctgtcaggt cttcggttcc tgccctccag ggcgcggatg ccggaaaccc
     9961 ggcccgtgcc gggtgtgagg aacaccgcat gcccgtccag ccgcagccgt aatacgcgat
    10021 cttggagttg tggcgcctgt gatgccggtt ccgccaggtt tgcgaggtgc cacaactcca
    10081 agatcggtgg cgggtctagc cggccgtacg ggccacgccg accgggcagc tcagcccgtt
    10141 cgggccgtgg ttgcagtagc cgttcgggtt cttcgtcgga gccaggtact gctggtggta
    10201 gtcctcggcg aagtagtagt cgccgagcgg ggcgatctcg gtggtgatct cacccttgcc
    10261 ggcccgggcc acgatcggcg cgaacgcgtc ccgcgacgcc ttcgcggcgg cggcctgctc
    10321 gtcggtggtg gtgtagatcg ccgagcggta ctgggtgccc acgtcgttgc cctggcgcat
    10381 gccctgggtc gggtcgtggt tctcccagaa gaccttgagc aggtcctcgt aggcgatctt
    10441 cgacgggtcg tagaccacct ggaccacctc ggcgtgcccg gtcatgcccg agcagacctc
    10501 ctcgtacgtc gggttggtgg tgtagccacc cgcgtaaccg gcggacgtgg tgatcatgcc
    10561 ggggagggtc cagaacagcc gctcggcgcc ccagaaacag cccatgccga agacggcgac
    10621 ctgcgcgccc tcggggaacg ggcccttcag cgtcgacggc agcacctcgt gccggtcggc
    10681 gatcggcatc gcgatcgggc ggcccggcag agcctggtca ggagagatca tctcggcctt
    10741 catgcggcgg aggaacacgg tgggactcct ctcttggctt tcccagcgtg caacagcgtc
    10801 ggcccccggt tccttacccg cccgcgctca cgtcaggcca gcgccgccga gatccgcccg
    10861 gcgaacgcct cggcctcggc gtcgtcggcg taccgggtac ggggccagaa gaagccgcgc
    10921 agcccgtccc ccttggtcct gggcaccacg tgggtgtgca ggtgcggtac ggactgggac
    10981 acccggttgt tcatcgccac gaacgtccca ccggacccca gaccggtctc caccgccaca
    11041 gcgatgcgct gcaccagccg gaagtagccg ggcagcgcgt cggccggcag gtcggccagg
    11101 gtgaccaggt gggtgcgggg cacgacgagc acgtggccct tgaacaccgg ccgggtgtcc
    11161 aggaacgcga ccccgtccgg ctcgtcggtg acccggaagg ccggcacctc gcccgccacg
    11221 atcccgcaga acacacaccc gctcatctct cccaccctag gcccaccccg tccaccccac
    11281 cttcaggcgc gaggggtcgc ggagggtggg tcaggagcgg tcgaggtagg tgtcccagtc
    11341 gtcctcaggg acaccggacg ggccggtctc accgttggcc aggcgggcgc ggatgtccgt
    11401 ctcccatcgg cgagcccagc gtctgagtcc gtcgatgtcg tcctcgccga gaccgtagga
    11461 ggcgaatgtc tccacctcca gctcgtcgat cccgcccaat cggtcggcca actcgtgaag
    11521 cgagaacgcg acggtgtgtc gggctcccaa ggattcgagt gccctgtatt ccacgatccg
    11581 gccggcggct cgtacgtcga tgtagtcgcg atgcgcggcg cggtcgtgaa gtgccctgac
    11641 cttcaggccg atggcgtcct ccagcgcgag cacagggccg atgtgcaacc tcgcgggtgg
    11701 cccgatcgcc tctttcagga ggtcgatctc gcaggcgaag tctggcccct cgaccagcaa
    11761 ccgggccatc cggggcgtcg cctcgacgac ccgacagtcg agcccctctg cccggtacac
    11821 gtcggtcagg cgcgccgcga ccaggggtag cggcagcgcg gttgcggtgg cgaagtcgat
    11881 gtcgcgggac tgccggtgca cgagatcgtg cgcggcgagg gcgtaaccac ctgcgagcac
    11941 cagaccgagg tcgtcaccgg cgcggaaacc gacgcgcagc aaacgcatgt gcaactcgtc
    12001 cacggctagg ccgtcaggcc aggcatccgg ttctcccaga tgcgaatcac tcggcgcgcg
    12061 gtcagcttgc agatgcggga ccagtcctgc cggagaagcg ctggattgac gtaccggacg
    12121 atgtcctcgc gctgcccgca gtccatcagc gtgcgataga gcgtgagccg ctgtccgctg
    12181 tcgtcgacat cgaactcggt gagcccggac cacgcgaggc gggtcggcag cgtgacccgg
    12241 ccgtgctcgg gccccttgag ctcgtccagg gacgtcggga tccggtcggc gacgccgtgc
    12301 aggcgagagg ggagcgcctc ggtcgtactc accggaccag tatggcggac tgccctgaca
    12361 ccctcgcggt tgtgactcgc gccgggttgc cgggagcggg accgggtgga ggactaacgt
    12421 ctgcggcatg aggcacggct tcgagacact cgcgatccac gccggtcagg ccccggaggc
    12481 ccgcaccggc gcggtgattc cgccgatcta ccagaccagc acgtacgccc aggacgccgt
    12541 cggcgcgccg cgcgagggct acgagtacag ccgctccggc aaccccaccc gggacgcgct
    12601 ccaggaatgc ctggcggcgc tggagggcgg ccaggtgggg ctcgccttcg ccagcgggct
    12661 ggccgccgag gacacgctgc tgcggaccgt ctgcaagccg ggcgaccacg tggtgatccc
    12721 ggacgacgcg tacggcggca cctaccggct gttcgccaag gtggccgagc gctgggggct
    12781 gacgtacacc ccggcgaagg tctccgaccc ggacgccgtg cgtgcggcga tccgcccggg
    12841 cgccacccgg atcgtgtggg tggagacgcc gaccaacccg ctgctcggca tcgccgacat
    12901 cgcggcgctg gccgccgtgg cgcacgacgc cggcgcgctg ctggtggtcg acaacacgtt
    12961 cgcctcgccg tacctgcagc agccgatcgc gttcggcgcg gacgtggtgg tgcactccac
    13021 caccaagtac gtcggcggac actccgacgt ggtcggcggc gcgctcgtct ccgcggaccg
    13081 ggcgctcggc gaggagctgc gctaccacca gaacgcgatg ggcgcgatca acggcccgtt
    13141 cgacgcctgg ctcaccctgc gcggcatcaa gaccctcggg gtacggatgg accggcactg
    13201 cgacaacgcc gagcggatcg cggcctacct ggacggcaac gcgaaggtcg cgcaggtcat
    13261 ctacccgggg ctgccctcgc accccggcca cgaggtggcc gccaagcaga tgcggcggtt
    13321 cggcggcatg atctcgttcc gcgcggcggg cggcgaggag cacgccgtgg agatctgcaa
    13381 ccgggcccgg ctgttcgtgc tcgccgagtc gctcggcggc gtcgagtccc tgatcgagca
    13441 ccccggccgg atgacacacg cgagcgctgc gggctcgccg cttgaagttc ccggcgatct
    13501 cgtgcgactg tctgtcggca tcgagacggt cgacgacctg ctcgccgatc tggagcaggc
    13561 cctgggctga ccgctggctg gggagggtgg cagtgccgga gatcttgccg acgacgtggg
    13621 tcggtgcgac cgcgaaacag atcgcccggg cggtacgccg tggcgacgtc tctgccaccc
    13681 aggtcgtcgc cgaccacctg gatcacgtgg cccgggtcga cgccgagctg gccgcgttcc
    13741 gcacggtacg cggcggtgag gcgatcaccg aggccgagaa ggtcgacgag caggaggaac
    13801 tggcgaacct cccgctcgcc ggcgtcccgg tggcggtcaa ggagaacacg ccggtggccg
    13861 gcctgcccac gtggaacggg tcggccgcga tgcgtaccgg cgtggcggag gccgaccacg
    13921 aggtggtccg gcggctgcgc ggcgcgggcg cggtgatcct gggcgtgacc cggatgccgg
    13981 aactgggcct gtgggcgctc accgacgacg acagcggggc cacccgcaac ccgtgggaca
    14041 cgacgcgtac ccccggcggc tcctccggcg gcgcggccgc cgcggtggcc gccgggctgg
    14101 tgccgatggc ccacggcaac gacggcctcg gctcgatccg tattccggcg gcctgctgcg
    14161 gcctggtcgg gctcaagccc ggccggggcg tggtgccctg ccagctcggc gcggaggact
    14221 ggttcggcct gaccgagcac ggcatgctca ccagcaccgt ggccgacgcg gtggtcggct
    14281 tctcggtgct cgccggtcgc cggccggaca agctggtccc accggcgcgg ctgcgggtcg
    14341 gcgtctcgct ccgctcgccg gtgcgcggcg tctccccgga cgcgccgaac cgggacgcgg
    14401 tcgccgccgc cggccggctg ctcgccgccg ccggtcacga caccgtgccc accgacccgg
    14461 tctacccgac ccggctgggc ctgcagggca tcgccacctg gttcgcggcg gccgccgccg
    14521 acgtgcgcgc cgccggggtc gccccgcgcc agctccagcg gcgcagccgc cggcacgtca
    14581 cgctgggcga gtgggcgcag cgccgggggt acgtgcggga ggccgaccgg accgcctggc
    14641 gcgaacggtc ggtgaacttc ttcgcggaca actcgatcga cctgctgctc accccggcgt
    14701 tggccgggcc gccgccggag gccgccggct ggtccggccg ctcctggctc gcgaacatgt
    14761 cggcgaacat caggtacgcc ccgtacgcgg cgccgtggaa catcgccggg ctg
//
