LOCUS       NZ_CP031455            25779 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces olivoreticuli subsp. olivoreticuli strain ATCC 31159
            chromosome, complete genome.
ACCESSION   NZ_CP031455
VERSION     NZ_CP031455.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivoreticuli subsp. olivoreticuli
  ORGANISM  Streptomyces olivoreticuli subsp. olivoreticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Complete genome sequence of Streptomyces olivoreticuli ATCC 31159,
            producer of anticancer bestatin and diverse secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2018) Tianjin Key Laboratory of Food
            Biotechnology, College of Biotechnology and Food Science, Tianjin
            University of Commerce, NO.409 Guangrong Road, Tianjin, Tianjin
            300134, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-JUN-2018
            Assembly Method                   :: SMRT Link v. 5.1.0
            Assembly Name                     :: TJCU_BT_311
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: SMRT Link v5.1.0
            Genome Coverage                   :: 145.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003391135.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 04:49:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,562
            CDSs (total)                      :: 7,459
            Genes (coding)                    :: 7,276
            CDSs (with protein)               :: 7,276
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 183
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 183
            Pseudo Genes (frameshifted)       :: 61 of 183
            Pseudo Genes (incomplete)         :: 150 of 183
            Pseudo Genes (internal stop)      :: 18 of 183
            Pseudo Genes (multiple problems)  :: 41 of 183
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:12:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8536585
            Orig. end                         :: 8562364
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Hongyu Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25779
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /product="butyrolactone"
                     /region_number="46"
                     /rules="atropopeptide_p450"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..25779
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /detection_rules="AfsA"
                     /kind="neighbouring"
                     /product="atropopeptide"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21074
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21074
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11074](-)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11074)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     misc_feature    257..275
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.88"
                     /tool="antismash"
     gene            260..1084
                     /locus_tag="DXZ73_RS36525"
     CDS             260..1084
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (26-133). E-value:
                     1.7e-18. Score: 59.1. Matches aSDomain:
                     nrpspksdomains_DXZ73_RS36525_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141178.1"
                     /locus_tag="DXZ73_RS36525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_116216119.1"
                     /sec_met_domain="PF00561 (E-value: 2.7e-15, bitscore: 55.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.2e-16, bitscore:
                     58.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTETTIHRVPVAGGTLDVRRRGQRGPTLVFAHYWGGSAGTWDAV
                     VERLPADRDTARFDQRGWSSSRALPGPYHLDQLADDLIGLVEGLGLDRFVLVGHSMGGK
                     VCQLVAARRPAGLAGLALLAPAPPEPPAGLTVEHRRSLAHAYDSARTVGQALDDALTAA
                     PLEETVRSAVVRDSLAGDDAARREWPLRGIAADVTDAARAIDVPVVVLAGEHDKVEPPH
                     VLRRHLLPYAPQARFGVVPGSGHLLPLEAPEAVAAALEDFVSGPGGAGRLMR"
     aSDomain        338..658
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DXZ73_RS36525_Abhydrolase_1.1"
                     /evalue="1.70E-18"
                     /label="DXZ73_RS36525_Abhydrolase_1.1"
                     /locus_tag="DXZ73_RS36525"
                     /protein_end="133"
                     /protein_start="26"
                     /score="59.1"
                     /tool="antismash"
                     /translation="PTLVFAHYWGGSAGTWDAVVERLPADRDTARFDQRGWSSSRALPG
                     PYHLDQLADDLIGLVEGLGLDRFVLVGHSMGGKVCQLVAARRPAGLAGLALLAPAPPEP
                     PAG"
     CDS_motif       443..484
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DXZ73_RS36525_0001"
                     /evalue="3.90E+00"
                     /label="NRPS-te1"
                     /locus_tag="DXZ73_RS36525"
                     /protein_end="75"
                     /protein_start="61"
                     /score="0.3"
                     /tool="antismash"
                     /translation="GWSSSRALPGPYHL"
     CDS_motif       539..595
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DXZ73_RS36525_0002"
                     /evalue="3.80E-05"
                     /label="NRPS-te1"
                     /locus_tag="DXZ73_RS36525"
                     /protein_end="112"
                     /protein_start="93"
                     /score="16.2"
                     /tool="antismash"
                     /translation="FVLVGHSMGGKVCQLVAAR"
     gene            complement(1074..1604)
                     /locus_tag="DXZ73_RS36530"
     CDS             complement(1074..1604)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS36530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162890472.1"
                     /transl_table=11
                     /translation="MTVSRSWMRSVALAAVTALVTCVPAPASAHPPPPGQLQCQGTESV
                     TYDPGVTLLPRKFDVRTVGRFGLCVDSAGEVTSGSYGEHFSLSAGCNDLLGGFKEQRTF
                     AWDTGDSSVVEADGSSTAVAGQVVTTITGTVTRGRFLGRTAVQVITLPQPGVLQCLTTG
                     FTGAKGVTTLVIA"
     gene            1824..2651
                     /locus_tag="DXZ73_RS36535"
     CDS             1824..2651
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-150). E-value:
                     7.4e-13. Score: 40.6. Matches aSDomain:
                     nrpspksdomains_DXZ73_RS36535_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004993472.1"
                     /locus_tag="DXZ73_RS36535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_116215221.1"
                     /sec_met_domain="PF00561 (E-value: 4.5e-09, bitscore: 35.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDALEIGTLEVPGARLYFEVRGTGPLLLLIAGGGLDAAVFGRLAA
                     VLATDHRVITYDPRGNSRSLLDGPPEDQKVEVHTDDACRLLNHLAAADERAHVFGSCSG
                     ALVALELVLRHQGRVRSVIAHEPPAMALLPDAEKHLAFFEDAHEAFLREGVAPALRKLR
                     PAFGGHRAPALPEAQDNNAFFLAHIIRPTTRFVPDLTALAAAADRIVMAGGRDSRTHLI
                     HRPAAVLAEWLGRGLAEFPGGHTGYAQYPAEFAQRLVELLPAATAPAPSPLQG"
     aSDomain        1896..2273
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DXZ73_RS36535_Abhydrolase_1.1"
                     /evalue="7.40E-13"
                     /label="DXZ73_RS36535_Abhydrolase_1.1"
                     /locus_tag="DXZ73_RS36535"
                     /protein_end="150"
                     /protein_start="24"
                     /score="40.6"
                     /tool="antismash"
                     /translation="PLLLLIAGGGLDAAVFGRLAAVLATDHRVITYDPRGNSRSLLDGP
                     PEDQKVEVHTDDACRLLNHLAAADERAHVFGSCSGALVALELVLRHQGRVRSVIAHEPP
                     AMALLPDAEKHLAFFEDAHEAF"
     gene            2655..3911
                     /locus_tag="DXZ73_RS36540"
     CDS             2655..3911
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828245.1"
                     /locus_tag="DXZ73_RS36540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_116215223.1"
                     /transl_table=11
                     /translation="MRILMGAQNCGFGPASELVAVSRLLSGHERVFVGDGVSAVFARRN
                     ADAFDDIREAATQETAEAGSAMVDDLLRTGDLVVSVMDAALVVRSVVARRPVVMVDSLL
                     SFWQVGRPLTEIRELCASMPRSSFAAADRHLEVLSPHERVVAAHLLATHSVVQNFPGVT
                     RRAAEFAALETGCAMHVTGSVIDLEGLRKVPGDAEPEYDLLINVGGFKNFLLDFDVNND
                     YVRLLHRWITDLLRDWHRFPRVLVCGGPFGEHRERTVSVAGRRADCCFLPQRELLRQVA
                     SAPDYLLAPGLTALHEALALGRLPLAIHEQHYAHVFTVRQLDGTLFGRTAGRFADVLPR
                     HRIPEDDFAGTAALVEIAGRIREDDELYARFRRTFNERIEHYVSLTPAQRRQGVEELRG
                     VFDGDPVSSVMAGIVTHPE"
     misc_feature    3923..3940
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.57"
                     /tool="antismash"
     gene            4057..4905
                     /locus_tag="DXZ73_RS36545"
     CDS             4057..4905
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ClassB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669485.1"
                     /locus_tag="DXZ73_RS36545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_116215225.1"
                     /transl_table=11
                     /translation="MTTPTPLSYEVFVSDGTPRAGDQRMPNGDPIVSSPLSSTLIHGER
                     DAVLVDPPMTREQTEKVGDWIERSGKRLAYIYATHGHGDHWFGAAQLVERFPGATVYAT
                     EGTIRLMRRQATEGREQLWDKVFPGLIGDTTVLARPIPDQGFLLEGNVLEAYEAGHTDT
                     DDTTFLHVPSIGLVVAGDIVYNGVHPYILEGGDGGLAAWLEAIDRIAALQPRAVVAGHK
                     NKDRADDPAILEETRQYLRDAQRLLAEKPAPREFFDRMMRLHGDRLNPGPLWYGALGLL
                     G"
     gene            5004..5579
                     /locus_tag="DXZ73_RS36550"
     CDS             5004..5579
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150814.1"
                     /locus_tag="DXZ73_RS36550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_116215226.1"
                     /transl_table=11
                     /translation="MEWPATARGSLTPAPGGLAFVQDLLNTIAMGKPRMPDLLDDLGAA
                     QEWLDAALASWTRATGRPHTPITLDGQDLEKLRAFRTDLQRAVRADDAEPAPLTTTATL
                     RLGPDGRIHADPHGTGWQRVASLSIVETYEAQRTDLWRRLKSCRNDRCAAAFYDRSRNN
                     SGVWHDVHTCGNAANLRASRARRRSPSA"
     gene            complement(5600..6088)
                     /locus_tag="DXZ73_RS36555"
     CDS             complement(5600..6088)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645458.1"
                     /locus_tag="DXZ73_RS36555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutathione peroxidase"
                     /protein_id="WP_116215227.1"
                     /transl_table=11
                     /translation="MSVHEVEINALQGGSADLRQYLGKAVLIVNVASRCGLTPQYAGLE
                     GLHERYAARGFTVLGVPCNQFMGQEPGTSQEIAEFCSATYGVTFPMTEKIEVNGDGRHP
                     LYDELVTTADAEGHTGDIRWNFEKFLIAPDGTVAARFAPQAEPDSAEVVAAVEKNLPA"
     gene            complement(6133..6786)
                     /locus_tag="DXZ73_RS36560"
     CDS             complement(6133..6786)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013053.4"
                     /locus_tag="DXZ73_RS36560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cysteine hydrolase"
                     /protein_id="WP_116215229.1"
                     /transl_table=11
                     /translation="MDERSGLAVPRSLEEACDPQRLALLVYDMQVGILEQIGERDRVVS
                     RVTEVVGAARAAGVRTYFLRHVTLPVELMGVSQLRMWRGWQRAERATDVLSPFPPHAAH
                     TQLLPELRPTDREAVVDKITMSAFEGTWLDIALRDCGITTVAVVGVAMEIGIEPTVRHA
                     ADLGYIPVVITDACGAGDTEAAEHSLAALRFAGDAVLTTAEEFRSVLSRSSART"
     gene            6988..7488
                     /locus_tag="DXZ73_RS36565"
     CDS             6988..7488
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS36565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="DUF1003 domain-containing protein"
                     /protein_id="WP_116215231.1"
                     /transl_table=11
                     /translation="MTIYQHLPHPHIAARDARGPVKVTDQHPRGSAVTRFNTKVAIVVT
                     RAVGSMWCAYAFALFDLISLPDAIDAGSAAIVSWVAQTFLQLVLLSVIMVGQNVQAAAS
                     DKRSEATFHDASATLHEMAHLQGHLAAQDALLTRIAEKIGLEPVPVIDTPTADEPEGEL
                     PAG"
     gene            complement(7536..8609)
                     /locus_tag="DXZ73_RS36570"
     CDS             complement(7536..8609)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538980.1"
                     /locus_tag="DXZ73_RS36570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_240351653.1"
                     /transl_table=11
                     /translation="MGRWCLRHLQLLPVLLLCAGALLDYNTSPHFSAEAFYTAAPMTAA
                     ALLSLRATILAGIGACAADAALLTHFGFLGDSGGRSELAAVATVSAFAVVVNRLMYYSA
                     AQLHSARKIALAVQRAVLPQPPASIGHLRIAVRYQSAVKGAQIGGDLYGVQDTPYGVRC
                     LVGDVRGKGMEAVKAVDVALGVFREAAEEEPTLVRLAARLERALLREARRRAGPERTEG
                     FVTGVLAEIPHSGDELRLLNRGHPAPLLLHGGEVRSAEPSEPTLPLALGELGSDEDRID
                     TLPFPPGTTLLLYTDGLTEARNRAGVFYDPGARLTGQVFSGPDALLDALLTDVRHHTGG
                     CITDDMALLAVTLDAGH"
     gene            complement(8818..10014)
                     /locus_tag="DXZ73_RS36575"
     CDS             complement(8818..10014)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="DXZ73_RS36575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_116215234.1"
                     /sec_met_domain="p450 (E-value: 6.2e-26, bitscore: 89.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEIEILSPSYFDRAHAVHRLWREDGGVRHVRYPGPAAIEGWVVT
                     RYDDARELLADPRLSKQDAVRKFGQHVGLTEGPGGALFTHMLNSDPPEHTRLRKLVQKA
                     FTARRTAALRPMIEAHVTALLDTWGDSEEAELISEFALPLPVAVAFDLFGATDADHEVL
                     HVRGNTLGGGQGDGEVSVFTAESMLAYLKALIALKREAPDDGMLSALIAARDTDDALSE
                     DEITSMAFLLVVAGHQTTVNLIANGVHTLLTHPDQLDMLRADPSLMPGAVEEILRYESP
                     SSLASLRYTTEPVTVGEVTIPEGEFVQICPLGANRDPAVFDDPDRFDIRRETAAKHIAF
                     GHGIHHCLGAPLARLQAEIAFTGLLRRFPDLRLAEGHEVRWQPNPRHRGLLALPLRLR"
     gene            complement(10001..11074)
                     /locus_tag="DXZ73_RS36580"
     CDS             complement(10001..11074)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000172: Biaryl bond formation (68% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963544.1"
                     /locus_tag="DXZ73_RS36580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_116215236.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 3e-181,
                     bitscore: 600.8, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 9e-15, bitscore: 53.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSSTQHPAARRTTVFAPRLQALFDDHLGKDLVRLEPDTIGISGA
                     ELSDRILAARKATETERPTFKPLHGRSIPKSEASAGIRTIGQDIREALTRPIPERTDLS
                     GPWPFTGHMFLRDLILRDDPYRLRILMSRKLEIDPKLTWTTITVGAALPRRPGPGPRLT
                     HTANLFAEAKGYHDRRYAMGMYRRLAAPVCFTISALVANALWLGSPFDEGVPNRNILHE
                     SLRLLPPSWNLLRNRSPEYPALDSRIGPGDDVLMLPLLTHRDPALWDAPNEFRPGRWDT
                     LDPDNTPGYMPFGHVSERCWGRHMVMPLAELLLDHVRRTGLVVAPGQRTAEVPLLGLLG
                     VKKIHVGPKSKVRHARD"
     gene            11693..12049
                     /locus_tag="DXZ73_RS36585"
     CDS             11693..12049
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031463.1"
                     /locus_tag="DXZ73_RS36585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF805 domain-containing protein"
                     /protein_id="WP_116215238.1"
                     /transl_table=11
                     /translation="MHWYVDVLKKYAMFSGRAHRQEFWMFTLVSFVISIVLAVVDAALG
                     TSPVLGALYSLAVLLPSLAVGVRRLHDTDRTGWWLLIALIPIVGAIVLLVFWASAGKMH
                     DNAYGPNPQEVPAH"
     misc_feature    complement(11715..11724)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     gene            12202..13074
                     /locus_tag="DXZ73_RS36590"
     CDS             12202..13074
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358227.1"
                     /locus_tag="DXZ73_RS36590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_116215240.1"
                     /transl_table=11
                     /translation="MSTEQEWDIVSGIGITALAVAVGRAVETVRPDALARDPYAARFLE
                     EARPPAPLPTTVAEALAMEGQPDWSAIAGYLAVRTRAFDDFFQRAVDAGVTQIVLLASG
                     LDTRPFRLPWPENTVAYEIDQPQVLDFKMRVLRKYGATTACDHRPVPVDLRHDWAAALE
                     KAGFDRSRPTAWLAEGLLPYLPPKAEDDLFHEIHRLSAPGSRLAVEYIGDVQEVLDSYA
                     AGHHAQPPDADISSVLHTDRRPAPGARLSALGWETRGVPAVEAAEGYGRPLDPASSMTG
                     AAYAFARRP"
     gene            complement(13146..14399)
                     /locus_tag="DXZ73_RS36595"
     CDS             complement(13146..14399)
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.4"
                     /locus_tag="DXZ73_RS36595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_116215242.1"
                     /transl_table=11
                     /translation="MAGIRLARSVATLATTVVLVAGSAAGASAEQAPGTPDISGVRAAL
                     QRVVDSGAPGAFAVIRDHGNPELDRSLAVGKADLDGTPMNADWRFRVGSNTKMFTSVLV
                     MRLVEQGRIDLDKPLRDYLPQGTLPESWQMTGRQVMEHRAGVYDYTNDLLEQSGEETTA
                     AFEKRIRNNVYEPKDLVAMSVKHGLQYTPGAAYSYSNTDYVLMGLAAERLTGRPYADLL
                     REQIFEPLKLRQTSFTVPEKGIAGQHVTGYLTNDDRSKPLLNSTEQTASWIWSAGGVVS
                     SAHDLDHFLTALMAGSRGGLVSDESLRQMTSVLPTSTAKVGYGLGVREIALSCGKVLGH
                     GGIVQGYQTQSFSSPDGKRTVIVFANASNNGSITQGLTNTLEPAFCGKTPASPAPRNSL
                     TGNGSGGRWVPAVEDSRI"
     gene            14529..14693
                     /locus_tag="DXZ73_RS36600"
     CDS             14529..14693
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018555921.1"
                     /locus_tag="DXZ73_RS36600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_116215243.1"
                     /transl_table=11
                     /translation="MTALQQCAQRQETSVHDIVLRAVDEYLDAAHQASVHRTAQEQAAK
                     WRQLMDRLK"
     gene            14951..16114
                     /locus_tag="DXZ73_RS36605"
     CDS             14951..16114
                     /EC_number="2.8.3.-"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014564.4"
                     /locus_tag="DXZ73_RS36605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CoA transferase"
                     /protein_id="WP_116215245.1"
                     /transl_table=11
                     /translation="MPRAFSGVRVLDLTHVLAGPFAAYQLAVLGADVIKIEPPDRPDFV
                     RGRGPDPGLNKQLRGVNYQVQGGNKRAMTLDLKTAGGREVFRSLAGTADVVIENYRAGA
                     LARLGVGYEELSAVNPGLVYCSMTGYGQRGPRAEVNAYDNVVQAASGVISQCDGHKPNL
                     AFIDYGSGYNAAFAIAAALYARSRDGRGQHIDCAMFDTALMLMAPAVSAQLHPGEREEP
                     VQESGLGAYETSDGVFVLGTPTPDQNRRLWAALAADGHPHPQFEALGSMDELLEHSGAM
                     REALREVFRTRSAARWEEWIHRHGLPGERVRTLAEAVDEEQLKHRTFLQPARDGDPAVP
                     VAAFGFAHDGPSRDRPAPGFGEHTVEILEEMGLSTEDIDRLRAEGVI"
     cand_cluster    14964..25779
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    14964..25779
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[19963:20779](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(19964..20779)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="2"
     gene            complement(16149..17126)
                     /locus_tag="DXZ73_RS36610"
     CDS             complement(16149..17126)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152255.1"
                     /locus_tag="DXZ73_RS36610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_116215246.1"
                     /transl_table=11
                     /translation="MFTTLGLEAADEEVYREMLESPGRGVDEIAARLATCPDRVRACLD
                     KLFELRLIQESFEAPGRFFAVEPAMGFQQLLARQHDELIERQRQIADSHGSFIRMLAGT
                     GPRPSEGGGVERLEGMDAVQRRLQELARDTVREALTFMPDGPQSAAALDAARRNDARAL
                     ERGVTIRTIGPHRMREDAATREYARRLSDRGGEFRTTAGLPPRMILADRAVALVPIDAT
                     DTRKGALCLSDPGLVALLVALFEQTWSLSTPLDAGRQLLGEPLAEPERALLSFMAQGHT
                     DESAAGQLHVSPRTARRMMASIMERLGARSRFEAGLKAARLGWL"
     misc_feature    17120..17133
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.27"
                     /tool="antismash"
     gene            17433..17624
                     /locus_tag="DXZ73_RS36615"
     CDS             17433..17624
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS36615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116215248.1"
                     /transl_table=11
                     /translation="MAVPTRIPRTALSVPPAPAGATGPRPLGAPADDRARTAPVPDLPP
                     TAGDTLVARAAPAGFIWD"
     gene            17636..17986
                     /locus_tag="DXZ73_RS36620"
     CDS             17636..17986
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS36620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116215249.1"
                     /transl_table=11
                     /translation="MQLTVITLTAAEDRARQVLDGAQVAAAMWAAADAEDRLEHISTRS
                     LPGHFRLGIFTAALPEHAAMAAALGICHRALATSPLLHGWSVAAVSGGPRPPDRTPAEP
                     RATPPPSTPEGP"
     gene            complement(18090..19967)
                     /locus_tag="DXZ73_RS36625"
     CDS             complement(18090..19967)
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_function="GO:0003997 - acyl-CoA oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013883.4"
                     /locus_tag="DXZ73_RS36625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_116215251.1"
                     /transl_table=11
                     /translation="MTDPAPGPSGPTSMRRLLHGDRLRHLARLDRLLDRPCFDRSPSTG
                     PADARHERTYSRLRALGLDAGGSLALHHDRSRLLTALEWAATVDPGLFLTALVHFSVVT
                     CTLVELGRPGGGLAPLIEDLDAMDAVGGILITELGNGSSHLGPATEARYHHANRTFTLH
                     TPGPEAAKFMAPGGAPGRSRIVVVYARLLIDDHEHGVFPFAVRLRHGATTAPGVRITPL
                     PPTSLVPLDYAVISFDGTPVPYDGWLRDSADITDDGRFEDPLDGSGHRLVRSLSASAHA
                     SVGAAAGQAAAARAAVAIALRYSRGRTTMGRLAPRLPVLEYRTQQEALYSALARAYAAT
                     FLVNEERERFVRGVHSGPPAAGGTPPTWAPWSAAHRDLALAKAWTSGTLEQVAAVCRQR
                     CGAQGVLSMNRITDYEDLARIFHAAAGDTLLIHLDAGKSLLAEPPPPAAEPPAGPLDVA
                     DPRTAVGLARLRESRLHTDLTRRLDEASGAGSGNGLRPQASDEFAVWNPLLPGLVDLAV
                     AHTKRVVLERFQHQAEALAGSPDEPALAALHHLLSLDSIEEDLGWHLEHADLTPDEGRL
                     VHGARPRALAAVHTHLPALLDTLALPPARLGAPIGQPDWLRAVLDSAHH"
     gene            complement(19964..20779)
                     /locus_tag="DXZ73_RS36630"
     CDS             complement(19964..20779)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014043941.1"
                     /locus_tag="DXZ73_RS36630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AfsA-related hotdog domain-containing protein"
                     /protein_id="WP_116215252.1"
                     /sec_met_domain="AfsA (E-value: 5.1e-11, bitscore: 41.2,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPRILWVVGESFSRATVHPQVVTARDLRDRLARHTPEPGIRPT
                     VVPGLGIDENTWADLCESMAEADARPADTHRPPRPVPRHRVLKHAQDNVLIGDARAADG
                     RFGARLTVPNETEMIRDHTADQQHVPGMLLIEACTQLITWAVAELVAPPPGQGDRYAVM
                     HALETDFERFVFPLPAELDGTLRVTGPPEDHRVPLTAEVTIRQSGRVCVSCRVRLHAFD
                     PAHIFAIEHAQAMRTLERSAHPAGQTGTADPVPPGPPILVSPGAQEAAP"
     misc_feature    complement(20736..20751)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.83"
                     /tool="antismash"
     gene            complement(20894..21934)
                     /locus_tag="DXZ73_RS36635"
     CDS             complement(20894..21934)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151661.1"
                     /locus_tag="DXZ73_RS36635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ketoacyl-ACP synthase III"
                     /protein_id="WP_116215253.1"
                     /sec_met_domain="fabH (E-value: 1.8e-88, bitscore: 295.6,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHRIGILGTGAFLPPTVRTNAEVGARTGISPEWILERTGVRRRH
                     IAGPGQATSDLAAEAVREALECAGIAAEQLDLLVLATSTPDELGPSTACRVQASLGARN
                     AVAFDVSAACSGWLFATRVARDWLLGDPGARYAAVVGCEVYSPFVDAADRPTAVLFADG
                     AAATVMGPVPVGEGFGAIALGSDGRRAGDVLIPAGGSRRPASDATLADGGHHIVMDGHA
                     VRDFIVDIVPRAVATALEQADLTLGEVDVVVMHQPNPVLLRGVGESLGIDPDRLVVIGD
                     RVGNIGAGSLPFGLAHAAAEGRIKTGDRVLLVGFGAGLTWGSTVLTWSGTTKPARSPLL
                     AATYGP"
     misc_feature    complement(22151..22165)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.17"
                     /tool="antismash"
     gene            22189..23469
                     /locus_tag="DXZ73_RS36640"
     CDS             22189..23469
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="DXZ73_RS36640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_116215255.1"
                     /transl_table=11
                     /translation="MSSDASGGVHRSVIVSLIGTTLVWYDFFLYVSASVLVFNHRFFPY
                     LTPFAGTLMSVGLYGVGLVARPAGGVLCGHLGDRHGRRPALVATLVLTGASTGLIGVLP
                     AYDRIGLAAPLLLVALRLLQGLGLGGAWGAAAVVSLECVPPERRGRISSWAQTGAPAGN
                     LLAFGMMTAVSASMTSEQFVTWGWRLPFLFSAVLVAVGLWARMRIEETPVFRALSAAGA
                     RRERPVVELVKDHRGGLLTAVAVAVGADVVLFTFSFGYVLTFLNIAGVPFTALLALTVL
                     SPLALIALIPLFGLLSDRCGRRRVCLAGTVATAVWAAGFLPLVRTASLPVLVVAYLLAL
                     AAFAAMYAPQAAIVAGLFPSHLRLSGTTTGYQLAGLLGSTLAAFLTTRAAGWFHTPAAV
                     PAYALAALLVSGGALLITRHAPEGADT"
     gene            23466..24032
                     /locus_tag="DXZ73_RS36645"
     CDS             23466..24032
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS36645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116215256.1"
                     /transl_table=11
                     /translation="MKRPWRLPVVVAVGALFTALALYDVSSAGAPTVITCDNTWTMNFT
                     PALTVASQDKVTAKVSDPNGALRKCTGDAAMTMGDFVAEGIGNSVTCAAGSYENTSSAL
                     QRVTWNARDNQLTSTYTWNMSPIGDLLSAQSPLNGGITEGRYKGATWTMAIDPIRSKIS
                     LTDCDSPTGLKSISVAGTLVITPAS"
     gene            complement(24080..24778)
                     /locus_tag="DXZ73_RS36650"
     CDS             complement(24080..24778)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437169.1"
                     /locus_tag="DXZ73_RS36650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_240351654.1"
                     /transl_table=11
                     /translation="MSTARSGGSGGPPAGNSRPAPLRRDARRNRELLIAAAREIYAEQG
                     MDAPLDDIARRAGVGNATLYRRFPTRGALIEAVFGESLNDTLRHGENARGAEDAWDGLV
                     HYLEGIFEGLAADRGANDLMTTSIPDIPSLDALKAHHHQTMTQLIGRAQKQGTVRADVT
                     VEDLLFLLAALGRVVPASEATAPGAWPRHLHLLLAGLRAEAAAPLPAPPLTPDQLTGTL
                     HALTNPRQQD"
ORIGIN
        1 cggcgacagc cgcggtccat gcgccgcagc cgctcgaagc tgagcacctc cacaccgaac
       61 cccgccccga cggccggggc gtaccgcagc tgccggactc cggggagctg accgctttcc
      121 ataagaagcg tgcgcctttc gaccggtttg ccttcgtggg ccgactgtag cgtctccgcc
      181 gtaccccgca ggtacggggt gtgaactcgg gcgggagcgg cgccgcgtgc gctcctcgcc
      241 ctttcggacg gaggccatcg tgtctacaga aaccacaatc cacagggttc ccgtggcggg
      301 cggcacactc gatgtgcgca ggcgcggaca gcgcgggccg acgctggtgt tcgcgcacta
      361 ctggggcggg tccgccggta cgtgggacgc ggtcgtggag cggctcccgg ccgatcgcga
      421 cacggcccgt ttcgaccagc gcggttggag ctcgtcacgg gcgctgcccg gcccgtacca
      481 cctcgaccag ctcgccgacg acctcatcgg tctggtggag ggcctgggcc tcgacaggtt
      541 cgttctcgtc gggcactcga tgggcggcaa ggtctgccag ctcgtcgcgg cccggcgccc
      601 ggcgggcctg gcagggctgg cgttgctggc ccccgcgccg ccggagccgc ccgccggtct
      661 gaccgtcgag caccggcgct cgctcgcgca cgcctacgac tcggcgcgga ccgtcgggca
      721 ggcgctcgac gacgccctga ccgccgcccc gttggaggaa accgtcagga gcgccgtcgt
      781 gcgcgacagc ctggcgggcg atgacgcggc ccgccgggag tggccgttgc ggggcatcgc
      841 ggcggacgtc acggacgccg ccagggcgat cgacgtcccc gtcgtcgtcc tggccggtga
      901 acacgacaag gtcgagccgc cgcacgtcct gcgccgtcac ctgctgccct acgcccccca
      961 ggcacggttc ggcgttgtcc cgggcagcgg gcacctgctg cccctggagg ctcccgaagc
     1021 ggtcgccgcg gcactggagg acttcgtctc cggtcctggc ggggccggtc gcctcatgcg
     1081 atgacgagcg tggtcacgcc cttcgcgccc gtgaagccag tggtcaggca ctgcagtacc
     1141 cccggttgcg gaagcgtgat gacctgcacc gcggtccggc ccaggaagcg gcctcgggtg
     1201 acagtgccgg tgatcgtggt gacgacctga cccgccacgg cggtgctgct gccgtcggcc
     1261 tcgacgacgc tgctgtcgcc ggtgtcccat gcgaaggtcc gctgttcctt gaacccgccg
     1321 aggagatcgt tgcagccggc ggagagggag aaatgctccc cgtacgatcc gctcgtcacc
     1381 tcgcccgcac tgtcgacgca caggccgaac cgcccgacgg tcctgacgtc gaattttcgt
     1441 ggcaggaggg tgacccccgg gtcgtacgtg acggactcgg ttccctgaca ctgcagttgc
     1501 ccgggtggag gcgggtgggc ggacgccggg gccggcacgc atgtgaccag cgcggtgacg
     1561 gccgccaggg ctacggaacg catccatgat ctgctgaccg tcatgcgtgg tctccttcgc
     1621 ggcgagtgac gtgaggtatg cgatgccccg ttcacgtacg cgcgagacgg gcgctcagga
     1681 gtgagggaac acgagcggac tcgcggaggg cgcgtgacgg catgcgcgcg cccggccgcg
     1741 gcgggtcctg ttctccgaac tcctcgccgt gagtagcctg gtggtgaccc tccgacgcca
     1801 cgcggttccg accctggagt gtgatggacg ccttggagat cggcacgctg gaagtgcccg
     1861 gcgccaggct ctacttcgaa gtgcgcggca cggggccgct cctgctcctc atcgcgggcg
     1921 gcggcctcga cgcggccgtc ttcgggcgcc tggccgccgt cctcgccacg gaccaccgcg
     1981 tcatcacgta cgacccgcgc ggcaactcgc gcagcttgct cgacggcccg ccggaggacc
     2041 agaaggtcga ggtgcacacc gacgacgcct gccgtctgct gaatcacctc gctgcggcgg
     2101 acgagcgggc gcatgtgttc ggcagctgct cgggtgcgct ggtcgcgctc gaactcgtcc
     2161 ttcgccacca gggccgcgtc cggtcggtga tcgcacacga accgcccgcc atggcactcc
     2221 tgccggacgc cgagaagcac ctggcattct tcgaagacgc ccacgaggca tttctccgcg
     2281 agggtgtcgc accggccttg cgcaagctcc ggcccgcatt cggcggacac cgcgcgccgg
     2341 ccctgcccga ggcgcaggac aacaacgcgt tcttcctggc ccacatcatc cggccgacca
     2401 cgcgcttcgt tcccgatctc accgcgctcg ccgccgcggc ggaccggatc gtcatggcgg
     2461 gcggccgcga ctcccgcaca catctcatcc accgtccggc ggccgttctc gcggagtggc
     2521 tcggccgcgg actcgcggag ttccccggcg gccacaccgg ctatgcgcaa tacccggccg
     2581 aattcgccca gcggctcgtc gaattgctcc ccgccgcgac ggctccggcc ccttcaccgc
     2641 tccagggctg aagcgtgcgc atcctgatgg gggcccagaa ctgcggcttc ggcccggctt
     2701 ccgaactcgt cgcggtctcc cggctgctct ccggccacga acgggtattc gtgggcgacg
     2761 gcgtgtcggc ggtgtttgcg cggcgcaacg ccgacgcctt cgacgacata cgcgaagccg
     2821 ccacccagga gacggcggag gccggttccg cgatggtcga tgacctgctg cggaccggtg
     2881 atctggtggt ctcggtcatg gacgccgcct tggtcgtgcg gtccgtcgtg gcgcgccgac
     2941 cggtggtcat ggtggacagc ctgttgagct tctggcaggt cggacgcccg ctgaccgaga
     3001 tccgcgagct gtgcgcgagc atgccgcgct cgtccttcgc cgccgccgac cggcacttgg
     3061 aggttctctc accgcacgag cgcgtcgtcg cggcccatct gctcgccacg cacagcgtgg
     3121 tccagaactt cccgggcgtc acacggcgcg cggccgaatt cgccgctctc gaaaccggct
     3181 gtgcgatgca cgtgaccggc tcggtcatcg acctcgaagg cctgcggaag gtgccgggcg
     3241 atgccgagcc ggaatacgac ctgctgatca acgtcggcgg attcaagaat ttcctcctgg
     3301 atttcgacgt caacaacgac tacgtgcgac tgctccaccg atggatcacg gatctgctgc
     3361 gcgactggca ccggttcccg cgcgtcctgg tctgcggcgg gcccttcggc gagcaccggg
     3421 agcggaccgt ctccgtcgcc ggaaggcggg ccgactgctg tttccttccg cagcgcgaac
     3481 tgctgagaca ggtggcaagc gcccctgact acctgctcgc ccccggactc acggcgctcc
     3541 acgaggcgct ggctctcggg cggctgccgc tggccatcca cgaacagcac tacgcgcatg
     3601 tcttcaccgt gcggcagctc gacggcacac tcttcggccg gaccgccgga cggttcgcgg
     3661 acgtcctgcc gcgtcaccgg atacccgagg acgatttcgc cgggacggcg gccctcgtgg
     3721 agatcgcggg ccggatccgg gaggacgacg agctctacgc gcgattccgg cgcacgttca
     3781 acgaacggat cgagcactac gtctccctca cccccgcaca gcggcgccaa ggcgtcgagg
     3841 agctccgggg cgtattcgac ggtgatccgg tctcctcggt gatggccggg atcgtcaccc
     3901 accccgaatg acatagtcgt aagtgttacg gttatgtcat agggtcgagg tgacgccgga
     3961 ccggcgccag gcagagcgcc cggccgcggc cttgcccgac acggcgcttc acgcaccccc
     4021 tcccacagac accgaaagcc gaggagacgg tccgccatga ccacacccac gcccctgtcg
     4081 tacgaggtct tcgtctcgga cggcacaccg agggccggtg accagcgcat gccgaacggc
     4141 gacccgatcg tgtcgtcacc gctgtcgtcc accctgatcc acggagagag ggacgccgtc
     4201 ctggtcgatc cgccgatgac ccgcgagcag accgagaagg tcggcgactg gatcgagcgg
     4261 tccggcaagc ggctggcgta catctacgcc acccacgggc acggcgatca ctggttcggt
     4321 gccgcgcagc tcgtcgagcg cttccccggc gccaccgtgt atgccaccga gggcaccatc
     4381 cggctcatgc gccggcaggc gaccgaaggc cgtgaacagc tgtgggacaa ggtcttcccc
     4441 ggcctgatcg gcgacaccac ggtgctcgcc cggccgatcc ccgaccaggg gttcctgctg
     4501 gagggcaacg tcctcgaggc gtacgaggcc ggacacaccg acaccgacga caccacgttc
     4561 ctgcacgtgc cgtcgatcgg cctcgtggtc gccggtgaca tcgtctacaa cggcgtgcac
     4621 ccgtacatcc tcgaaggcgg cgacggcggc ctcgcggcat ggctggaggc catcgaccgc
     4681 atcgccgcgc tccagccgcg cgccgtcgtc gcgggccaca agaacaagga ccgcgccgac
     4741 gacccggcca tcctggagga gacccggcaa tacctgcgcg acgcccagcg gctgctcgcc
     4801 gagaagccgg ccccgcgcga gttcttcgac cggatgatga ggctccacgg cgaccggctc
     4861 aacccgggcc cgctctggta cggcgcgctc ggactgctcg gctgacgtgg ccccggcccg
     4921 ggggcgccgc cggggatcgg tgacactggt accgaccgcg tacggaccag gcaccgcggc
     4981 aggaaaaagg aggcgacccg cccatggaat ggccggcgac cgcacgtgga tccctcaccc
     5041 cggccccggg cgggctcgcc ttcgtccagg acctgctcaa caccatcgcc atgggcaagc
     5101 cgcgcatgcc ggacctcctg gacgacctcg gcgccgcgca ggagtggctc gacgccgcac
     5161 tggcctcctg gacccgggcc accggccgcc cccacacgcc catcacgctc gacggccagg
     5221 acctggaaaa actgcgcgcc ttccgtacgg acctccaacg cgcggtccgc gccgacgacg
     5281 ccgagcccgc gccgctcacc accacggcca cgctgcggct cggccccgac ggccggatcc
     5341 acgcagaccc ccacggcacc ggctggcagc gggtggcctc cctgagcatc gtcgagacct
     5401 acgaagccca gcgcaccgac ctctggcgcc gcctgaagtc ctgccgcaac gaccgctgcg
     5461 cggcagcgtt ctacgaccgc tcccgcaaca acagcggcgt ctggcacgac gtccacacct
     5521 gcggcaacgc ggccaacctc cgcgcctccc gcgcccggcg cagatccccc tccgcttaag
     5581 gccgcgccgc tcggacggct caggcgggga ggttcttctc gacggccgcg acgacctcgg
     5641 cggagtccgg ttcggcctgc ggggcgaagc gggccgccac cgtgccgtcg ggggcgatga
     5701 ggaacttctc gaagttccag cggatgtccc cggtgtggcc ctcggcgtcc gcggtggtga
     5761 cgagttcgtc gtacagcggg tgccgcccgt ccccgttgac ctcgatcttc tcggtcatgg
     5821 ggaaggtcac cccgtacgtc gccgagcaga actcggcgat ctcctgcgac gtgccgggct
     5881 cctggcccat gaactggttg caggggacgc cgaggacggt gaagccgcga gcggcatacc
     5941 gctcgtgcag cccctccagg ccggcgtact gaggggtgag gccgcatctg gaggcgacgt
     6001 tgacgatgag cacggccttg cccaggtact gccgcaggtc cgcggaaccg ccctggagcg
     6061 cgttgatctc tacttcgtga acagacatgt gaccggatgc tagccgggta cccggacgaa
     6121 cggcagaccg ggctatgtcc gcgccgacga ccgggagagc acggagcgga actcctcggc
     6181 cgtggtcagc acggcatcgc ccgcgaagcg gagcgccgcc aatgagtgct cggcggcctc
     6241 cgtgtcgccc gccccacagg catcggtgat cacgaccggg atatagccga ggtccgccgc
     6301 gtggcgcacg gtgggctcga tcccgatctc catggcgaca ccgacgacgg ccacggtcgt
     6361 gatcccgcag tcgcgcaacg cgatgtcgag ccacgtcccc tcgaacgccg acatggtgat
     6421 cttgtccacc accgcctcgc ggtccgtggg ccgcagctcg gggaggagct gggtgtgcgc
     6481 ggcgtgcggc gggaaggggg acagcacatc ggtcgcccgc tcggcccgct gccacccccg
     6541 ccacatgcgc aactgggaga cacccatcag ctcgacggga agcgtgacat ggcgcaggaa
     6601 gtacgtacgg acccccgcgg cgcgggcggc cccgaccacc tccgtcaccc ggctgacgac
     6661 acggtcacgc tcaccgatct gctccaggat gccgacctgc atgtcgtaca ccagcagtgc
     6721 caggcgctgc gggtcgcacg cctcctcgag cgaacgggga acggccagcc cacttcgttc
     6781 atccatggac gcgacgctat ccgctgtccc gcccgcggcc gcgcatacgc gcggacgcga
     6841 tggggaactt gcacagtcct gaccgaactc acaccccgag cacgcgcgtt gcggggtaca
     6901 accgcaatgc gggcggagtc gggcagcgag ccgctcaccc cgccggacgc gaccgtgggg
     6961 cccggcccct cgacaggaag tcaggtcatg acgatctatc agcatctgcc ccacccgcac
     7021 atcgccgcac gggacgcccg gggaccggtg aaggtcaccg accagcaccc gcgcggcagc
     7081 gcggtcacgc ggttcaacac caaggtcgcg atcgtcgtca cgcgggcggt cggcagcatg
     7141 tggtgcgcct acgccttcgc gctgttcgac ctgatcagcc tcccggacgc catcgacgcc
     7201 ggttcggcgg ccatcgtgtc ctgggtggcg cagaccttcc tgcagctcgt cctgctgtcc
     7261 gtcatcatgg tgggccagaa cgtgcaggcg gccgcttcgg acaagcgctc cgaggcgacc
     7321 ttccacgacg cgagcgcgac cctgcacgag atggcgcacc tgcagggcca cctcgccgcg
     7381 caggacgcgc tgctgacccg gatcgccgag aagatcggcc tcgaaccggt accggtcatc
     7441 gacaccccga cggccgacga gcccgaaggc gagctcccgg ccggctgacc gcctcgtcca
     7501 ctcgaggtcg aggacgaccg cgaccgcgcc cggagtcagt ggcccgcgtc gagcgtcacc
     7561 gcgagcaggg ccatgtcgtc cgtgatgcag ccaccggtgt ggtggcgcac atcggtgagg
     7621 agggcgtcga ggagcgcgtc cgggccggag aaaacctgcc cggtcaagcg ggcgccgggg
     7681 tcgtagaaga ccccggcacg gttccgcgcc tcggtgaggc cgtcggtgta caggaggagt
     7741 gtcgtccccg gggggaacgg cagggtgtcg atccggtcct cgtcggagcc cagctctccc
     7801 agcgccaggg ggagggtcgg ctcggagggt tccgcgctgc gcacctcgcc gccgtgcagc
     7861 agcagcggcg ccgggtggcc gcggttgagc agccgcagtt cgtcgccgga gtgcgggatc
     7921 tcggcgagca cgccggtgac gaacccttcg gtccgctcgg gtcccgcccg ccgcctcgcc
     7981 tcccggagca gcgcccgctc cagccgggcc gcgagccgga cgagcgtggg ctcctcctcg
     8041 gcggcctccc ggaacacccc cagcgccacg tccaccgcct tgacggcctc catgcccttg
     8101 ccccgcacgt cgccgaccag gcagcgcacg ccgtacggag tgtcctgcac gccgtacagg
     8161 tcaccgccga tctgcgcgcc tttcacggcc gactggtaac gcacggcgat cctcaggtgc
     8221 ccgatcgagg ccggtggctg cggcagcacg gcgcgttgca cggcgagggc gatcttgcgg
     8281 gcggagtgca gctgtgcggc gctgtagtac atgaggcggt tgacgacgac ggcgaaggcc
     8341 gaaacggtcg cgaccgccgc cagctcgctc cgcccgccgg aatccccgag gaagccgaag
     8401 tgggtgagca gcgcggcgtc ggcggcacag gcgccgatgc ccgccaggat cgtcgcgcgc
     8461 agcgacagca gagcggcggc cgtcatcggt gccgccgtgt agaaggcctc ggcgctgaag
     8521 tgcggggagg tgttgtagtc gaggagggcg cctgcgcaga gcagcaggac gggcagcagc
     8581 tggaggtggc gcaggcacca gcgccccacg gcagtgcgcc tcgcgcccgg tgccctcacg
     8641 tgcccgctcc cgctcttccg cgctggtcga cacgctcaag catcctcggg ccggatgacg
     8701 gctgccagtc atggggcggc cgtacgggtg cgtaccggat caccgcgggg ctccaccgca
     8761 ggctcgccct ggcgcgagcc gcctacgggg aaccggaccc gggaccgacc agggcggcta
     8821 ccgcagccgt agcggcaggg cgagcagtcc gcggtgtctg gggttgggct gccatcgcac
     8881 ctcgtgcccc tcggcgagcc gcaggtccgg gaaccgccgg aggaggccgg tgaacgcgat
     8941 ctcggcctgc agccgcgcga gcggcgcacc gagacagtga tggatgccgt gcccgaaagc
     9001 gatgtgcttc gcggcggtct cgcggcggat gtcgaaccgg tccggatcgt cgaacacggc
     9061 cgggtcgcgg ttggcgccga gcggacagat ctgtacgaac tcgccctcgg ggatcgtcac
     9121 ttcgcccacg gtgacgggct cggtggtgta gcgcagggac gccagactcg acggcgactc
     9181 gtaccgcagg atctcctcga ccgccccggg catcagcgac ggatcggcgc gcagcatgtc
     9241 gagttggtcg gggtgggtga ggagggtgtg gacgccgttg gcgatgaggt tgaccgtcgt
     9301 ctgatgcccc gccacgacca ggaggaaggc catggaggtg atctcgtcct cgctcagcgc
     9361 gtcgtccgtg tcccgggccg ctatcagggc ggagagcatc ccgtcgtcgg gggcctcgcg
     9421 cttgagggcg atcagcgcct tgaggtaggc gagcatgctc tcggcggtga acaccgacac
     9481 ctcgccgtcg ccctggcccc cgccgagcgt gttgccccgc acgtgcagca cctcgtggtc
     9541 cgcgtcggtg gcgccgaaca ggtcgaaggc gaccgccacg ggcaggggca gcgcgaactc
     9601 gcttatcagc tccgcctcct cgctgtcccc ccacgtgtcc agcagcgcgg tcacgtgggc
     9661 ctcgatcatc gggcgcagcg ccgccgtgcg ccgggcggtg aacgccttct gcacgagctt
     9721 gcgcagccgc gtgtgctccg ggggatcgga gttgagcatg tgcgtgaaca gcgcaccacc
     9781 gggcccttcg gtgagcccga cgtgctgccc gaacttccgt accgcgtcct gcttggacag
     9841 ccgcggatcg gccagcagtt cccgggcgtc gtcgtagcgg gtgacgaccc atccttcgat
     9901 cgccgcaggg ccggggtagc ggacgtggcg gacgccgccg tcctcgcgcc acaggcggtg
     9961 gacggcgtgc gcccggtcga agtacgacgg ggacaggatc tcaatctcgg gcatggcgca
    10021 ccttgctctt cggccctacg tggatcttct tcacaccgag cagcccgagg aggggcacct
    10081 cggccgtacg ctgcccaggc gcgacgacga ggccggtccg gcgcacgtgg tccaggagca
    10141 gttcggcgag cggcatgacc atgtgccgcc cccagcagcg ttcggacaca tggccgaagg
    10201 gcatgtaccc gggggtgttg tcggggtcga gggtgtccca gcgcccgggc cggaactcgt
    10261 tcggcgcgtc ccacagtgcg gggtcgcggt gggtgagcag cggcagcatc agcacgtcgt
    10321 cgccgggccc gatccggctg tcgagggccg ggtactcggg cgagcgattg cgcagcagat
    10381 tccacgacgg gggcagcagt cgcagggact cgtggaggat gttgcggttc gggacgcctt
    10441 cgtcgaaggg ggagccgagc cacagggcgt tcgcgacgag ggcggagatg gtgaagcaca
    10501 ccggcgccgc cagacggcgg tacatgccca tcgcgtaccg gcggtcgtgg tagcccttcg
    10561 cctcggcgaa gaggttcgcg gtgtgggtca gccgcggtcc cggccccggc cggcggggca
    10621 gggcggcccc gacggtgatg gtcgtccagg tcagcttcgg atcgatctcc agtttgcggc
    10681 tcatgaggat gcggagccgg tacgggtcgt cgcgcaggat caggtcccgc aggaacatgt
    10741 gcccggtgaa cggccacggc cccgacaggt cggtccgctc cggaatcgga cgcgtgaggg
    10801 cttcgcggat gtcctggccg atcgtccgga ttcccgcgga cgcctcggac ttggggatcg
    10861 accgcccgtg caggggcttg aacgtgggcc gctcggtctc cgtcgccttg cgggcggcga
    10921 ggatccggtc cgacagctcc gctccggaaa taccgatcgt gtcgggttcc agccggacca
    10981 ggtccttgcc gagatggtcg tcgaaaaggg cctggagacg gggagcgaat acggtggtac
    11041 ggcgggcggc cggatgctgt gtcgaggatg gcatgaatgc gggctccggg gaggatgcgg
    11101 agggcccgca cgggcaggag accgatcggc tctgccgcgt gcgggcccgg tgcggaaacc
    11161 ggctgggcct agtaccagac gtaccaggcg ctctgcttca gactgggctc gctcttcttg
    11221 aagaacggaa agtcacggca gatcgggttt cccgcgttgc gtacggcgga aaggaacttc
    11281 gacatcggcc atacacctcc tctctcattt tcgacacgcc gattggcgtt ccgggcacgg
    11341 aacttgattg ccaccggaaa aggtggggaa tggtcatgcc cggctgttga ggggagtgaa
    11401 gcggcctgtg ccggacactg tcaatgctct cctttgcgac ctcacgggat gcgatgtccg
    11461 tatatatggg cactattcct gcgaggaagt cgtgcggcgc cgccattcgt ccaccggaat
    11521 gcgatggtcc gtcaaggaaa cgtatgccac cgtgcgccgg aggccggacg tgcgccccgg
    11581 gcgcccgtcg gccgcctccg gacaacggtt gaccgccccc ctgaggccgc ctactttcgg
    11641 cttgaggccc aatccacgag ggcggggccc gctgtggttc ttgggggcgc aggtgcactg
    11701 gtatgtggat gtgctcaaga aatacgcgat gttcagcggg cgggcgcacc gccaggaatt
    11761 ctggatgttc accctggtca gctttgtgat cagtatcgtg ctggccgtcg tcgacgccgc
    11821 gctcggcacg agccctgtcc tcggagcgct gtacagcctc gccgttctcc tccccagcct
    11881 cgccgtcggc gtccgccgcc tgcacgacac cgaccggacg ggctggtggc tgctcatcgc
    11941 cctgatcccg atcgtgggcg cgatcgtcct gctggtcttc tgggccagtg cgggcaaaat
    12001 gcacgacaac gcctacggtc cgaacccaca ggaggtgccg gcccactgac ctcgcgcacg
    12061 ttgtggcggg cgtcgacacg gtcgtgaccg tggccttcgg ctcgggtgtc cgagcgggac
    12121 tagcatggtc gacgttcaat ggctgtcgtc ccgtggtccg ctgcgcgggg aggccggcgg
    12181 cccgatcgtg gggaggcgcc cgtgagcacg gaacaagagt gggacatcgt atcggggatc
    12241 ggcatcacgg ccctggcggt ggcggtcggc agagccgtcg agaccgtgcg gcccgacgcc
    12301 ctggcgaggg acccgtacgc tgcccgtttc ctcgaggagg cccggcctcc ggcgccgctg
    12361 ccgaccaccg tggccgaggc gttggccatg gaggggcagc cggactggtc ggccatagcc
    12421 ggctacctgg ccgtgcgcac ccgtgccttc gacgacttct tccagcgggc cgtcgacgcc
    12481 ggcgtcacgc agatcgtgct gctggcgtcg ggtctcgaca cccggccgtt ccggctgccc
    12541 tggccggaga acaccgtcgc ttacgagatc gaccagccgc aggtactgga cttcaaaatg
    12601 cgcgtcctgc ggaagtacgg cgccaccacc gcgtgcgacc accggccggt gcccgtggat
    12661 ctgcggcacg actgggcggc ggcactggag aaggcgggct tcgaccgttc gcgcccgacc
    12721 gcctggctcg cggagggcct cctgccctac ctcccgccca aggccgagga cgacctgttc
    12781 cacgagatcc accggctctc cgcccccggc agccggctgg cggtggagta catcggcgac
    12841 gtgcaggagg tcctggattc ctacgcggcc gggcaccacg cccagccccc ggacgccgac
    12901 atcagcagtg tgctccacac cgaccggcgg cccgcgccgg gagcgcgcct gtccgccctg
    12961 ggctgggaga cacggggcgt gccggccgtg gaggccgccg agggctacgg acgcccgctg
    13021 gaccccgctt cctccatgac cggtgccgcg tacgccttcg ctcgccggcc gtgattccga
    13081 ggaacgcccg ccgggctgcc accgcgtgat gcggtgtcag cccggcgggc gtgacctgca
    13141 gtccgtcaga tgcgcgagtc ctcaacggcg gggacccagc ggccgccgct cccgttgccg
    13201 gtgagcgagt tgcgcggagc gggggaggcg ggtgtcttgc cgcagaacgc gggctccagc
    13261 gtattcgtca acccctgcgt gatggaaccg ttgttggacg cgttggcgaa gacgatgacc
    13321 gtgcgcttgc cgtccgggct ggagaacgac tgcgtctggt agccctggac gatcccgccg
    13381 tggccgagca ccttgccgca ggacagggcg atctcccgca cgcccagccc gtagccgacc
    13441 ttcgccgtgc tcgtggggag cacgctcgtc atctgccgca gcgactcgtc ggagaccagc
    13501 ccgccgcggc tcccggccat cagcgcggtc aggaagtggt cgaggtcgtg ggcggaggag
    13561 acgacgcccc ccgcgctcca gatccaggac gcggtctgct cggtcgagtt cagcagcggc
    13621 ttgctgcggt cgtcattggt cagatagccg gtcacatgct ggccggcgat gcccttctcg
    13681 ggcacggtga aagaggtctg acgcagcttc agcggctcga atatctgctc gcgcagcagg
    13741 tcggcgtacg ggcgtccggt gaggcgctcg gcggccagac ccatcagcac gtaatcggtg
    13801 ttcgagtacg agtacgcggc ccccggggtg tactgcaggc cgtgcttcac cgacatggcc
    13861 acgagatcct tgggctcgta gacattgttg cggatgcgct tctcgaaggc ggcggtggtc
    13921 tcctcaccgc tctgctcgag gaggtcgttg gtgtagtcgt acaccccggc gcggtgctcc
    13981 atcacctgac gcccggtcat ctgccagctc tccgggagcg tcccctgcgg caggtagtcg
    14041 cgcaggggct tgtccaggtc gatgcggccc tgctcgacga ggcgcatcac gaggaccgag
    14101 gtgaacatct tggtgttgct gcccacccgg aaccgccagt cggcgttcat gggcgtgccg
    14161 tcgaggtcgg ccttgccgac ggccaacgac cggtccagct cggggttgcc gtgatcccgg
    14221 atcaccgcga acgcgcccgg agcccccgag tccacgacgc gctgcagcgc ggcccgcacc
    14281 ccggatatgt cgggcgtgcc cggggcctgc tcggcggacg cgcccgccgc gctcccggcc
    14341 accagcacca cggtggtcgc gagcgtggcc accgaacgcg cgagcctgat tcctgccata
    14401 agagagatac ctctgttccc cggcgacttg tgcgcagcgc cggttgcgta gcgtgcgtgc
    14461 gaccaagatc gtataggggt gccggaggct cttctcccgg cggtcccgcc gccctgcggg
    14521 acggccagat gaccgcactc cagcagtgcg cacagcggca ggagaccagc gtgcacgaca
    14581 tcgtgctgcg ggcggtcgac gagtatctgg acgcggccca ccaggcgtcg gtgcaccgga
    14641 cggcgcagga gcaggcggcc aagtggcggc aactcatgga ccggctcaag tgatgacctg
    14701 tctgacgccc cgggacgccc tgaccatcgc cgggtacgcc tgcgccgacg acacccccgg
    14761 cgtcctccgc gacacgggac aactggagtc cgctgccggg tgcttgtggc gcccgcagcc
    14821 aaggtcaccg accgggaggc gtccttgcgc cgggtcgagg ggccatggag tctgacggga
    14881 cggggccatc gcacgaaccg tcgcccggta ggcgcgtggc ccggcgtgaa tgtcatgaag
    14941 gaggttttcc gtgccgcgtg cgttctccgg tgttcgtgtc cttgacctga cgcatgtcct
    15001 ggccgggcct ttcgccgcct accagctggc ggttctcggc gcggacgtga tcaagatcga
    15061 gccgccggac cggcccgact tcgtacgggg ccgggggccg gacccggggc tcaacaagca
    15121 gctgcgcggg gtcaactacc aggttcaggg agggaacaag cgggcgatga cgctcgacct
    15181 caagaccgcc ggaggccgcg aggtcttcag gtccctggcc ggtacggcgg atgtggtcat
    15241 cgagaactac cgcgccggcg cgctggcccg gctcggcgtg gggtacgagg aactgtcggc
    15301 ggtcaatccc gggctcgtgt actgctcgat gacgggctac gggcaaagag gcccccgggc
    15361 cgaggtgaac gcctacgaca acgtggtcca agcagcctcc ggagtcatct cgcaatgcga
    15421 cggccacaag cccaacctgg ccttcatcga ctacggcagc ggatacaacg ccgccttcgc
    15481 gatagcagcc gccctctacg cccgctcccg cgacggccgg gggcaacaca tcgactgcgc
    15541 catgttcgac acggccttga tgctgatggc tccggcggtg tccgcgcagc tccatcccgg
    15601 cgaacgggag gagcccgtcc aggagagcgg actcggcgcg tacgagacgt ctgacggtgt
    15661 gttcgtcctg ggaacaccga caccggacca gaaccgacgc ctatgggcag cgctcgccgc
    15721 tgacgggcac ccgcatcctc agttcgaggc actgggctcc atggacgaac tcctggagca
    15781 cagcggggcg atgagggaag cgctgcgcga ggtcttccgc acgcgcagcg cggcccggtg
    15841 ggaggaatgg atccaccgcc atggacttcc cggcgaacgg gtccgcaccc tcgcggaggc
    15901 ggtcgacgag gagcagctga agcacaggac gttcctccag ccggcgcggg acggcgaccc
    15961 ggcggtgccg gtcgcggcct tcggcttcgc tcacgacgga ccgagccggg accggcccgc
    16021 tcccgggttc ggtgagcaca ccgtcgagat cctggaggaa atgggcctct ccacagagga
    16081 catcgaccgt ttgcgggccg agggcgtcat atgaatcgac ctctgcccca ccgccccgcc
    16141 cagcggcgtc agagccaccc gagccgagcg gccttgaggc cggcctcgaa gcggctgcgg
    16201 gcacccaggc gctccatgat cgaggccatc atccggcggg ccgtgcgcgg tgagacgtgg
    16261 agctggccgg cggcggactc gtcagtgtgg ccctgtgcca tgaaggagag aagggcgcgc
    16321 tccggttcgg ccaagggctc gcccaggagc tgccgcccgg cgtccagcgg ggtggacagt
    16381 gaccaggtct gctcgaacag ggcgaccagc agggccacca ggcccggatc ggacaggcac
    16441 agcgctccct tgcgggtgtc ggtcgcgtcg atgggcacca gggcgacggc gcgatcggcc
    16501 aggatcatcc gcggcgggag gccggccgtg gtgcggaact cgccaccccg gtcgctcagt
    16561 cggcgcgcgt actcccgggt cgcggcgtcc tcgcgcatcc tgtgcggccc gatcgtgcgg
    16621 atggtgacgc cgcgctccag ggcgcgggcg tcgttgcgcc gggcggcgtc gagggcggcc
    16681 gccgactggg ggccgtcggg catgaacgtc agggcttcgc ggacggtgtc gcgggccagt
    16741 tcctggagcc ggcgctggac cgcgtccatg ccctccaggc gctcgacgcc cccgccctcg
    16801 gagggccggg gcccggtccc cgcgagcatg cggatgaacg agccgtggct gtcggcgatc
    16861 tgacgctgac gctctatcag ctcgtcgtgc tgacgggcca gcaactgctg gaatcccatg
    16921 gccggttcca ccgcgaagaa gcggccgggc gcctcgaagg actcctggat cagccgcagc
    16981 tcgaacagtt tgtccaggca ggcgcgtacc cggtcggggc aggtcgccag gcgggcggcg
    17041 atctcgtcga ccccccgccc gggagactcc agcatctccc ggtagacctc ctcgtccgcc
    17101 gcctccaggc cgagtgtcgt gaacatactt tcccctttcg aggtggccag ttcctcgtgc
    17161 gggacagtct gcggggtcgc ggtcaacatc gggtcaacgt gcgtcgatcc atggcaggca
    17221 ggggccgacg ggcaaacggc gggagtggtt ccgtgacctc ggtgtcctgt cacaaagcgg
    17281 cctggacgct tccgcccccg atggagccgt tccttccggc agtgccgctc agcaagatgg
    17341 tgatcaccgg gacggcacgg aagaacagga acggaccgtg gccgcgagcg ggcccggccg
    17401 gcgaaccgag accgatcaga gaaggcgttc ccatggctgt gcccacccgc atcccccgta
    17461 ccgccctctc ggtcccgccc gccccggcgg gtgccaccgg cccccggccc ctcggtgccc
    17521 ccgccgacga ccgtgcacgg accgcccccg tgccggatct cccgcccacc gccggcgaca
    17581 ccctggtcgc ccgcgcggct ccggccggct tcatctggga ctgacgtgcc acgcgatgca
    17641 actgaccgtc atcaccctga ccgccgccga ggaccgagcc cgccaggtcc ttgacggagc
    17701 acaggtcgcc gccgcgatgt gggccgcggc cgacgccgag gaccgcctcg aacacatcag
    17761 caccagatcg ctccccggcc acttccgcct ggggatcttc accgcggcgc tgccggaaca
    17821 cgccgccatg gccgccgcac tcggcatctg ccaccgcgcg ctggccacgt ccccgctgct
    17881 gcacggctgg agcgtcgccg ccgtcagcgg cggtccgcgc ccaccggacc ggacaccggc
    17941 cgagccccgg gcgaccccac ccccttcgac acccgaaggc ccctgaccgg ggaccggacg
    18001 cactggtgac cgcagtgcgc gtggaggccg accgaccggg acgaccttcg gcgcggcggc
    18061 gagggccccg gccacctgcg gagacagcgt cagtggtggg cggagtccag gacggccctg
    18121 agccagtccg gctgtccgat cggggcgccg aggcgtgctg ggggcagcgc gagagtgtcg
    18181 agcagggccg gcaggtgggt gtggacggcg gcgagcgcgc ggggacgggc gccgtggacg
    18241 agccgtccct cgtcaggagt caggtcggcg tgctcgaggt gccagccgag atcctcctcg
    18301 atgctgtcca ggctcaggag atggtgcagc gcggccaggg caggctcgtc cggggagccc
    18361 gccagggcct cggcctggtg ctggaaccgt tcgagaacca cccgcttggt atgggcgacg
    18421 gcaaggtcga ccaggccggg gagcagaggg ttccacacgg cgaactcgtc ggacgcctga
    18481 ggacggaggc cgttgccgct gccggcgccc gaggcctcgt cgagccgccg tgtcagatcc
    18541 gtgtggagcc ggctttcgcg aaggcgggcg aggccgacgg cggtgcgcgg gtccgccacg
    18601 tcgagggggc cggccggtgg ctccgctgcc ggcggcggag gttcggccag cagcgacttg
    18661 ccggcgtcga ggtggatgag cagggtgtcg cccgcggccg cgtggaagat ccgtgcgagg
    18721 tcctcgtagt cggtgatgcg gttcatggac aacacgccct gcgcgccgca gcgttgccgg
    18781 cacacggcgg cgacctgttc cagagtgccg gaggtccatg ccttggccag ggcgagatcg
    18841 cggtgggccg cgctccaggg tgcccaggtg ggcggggtgc cgccggcggc cggcggcccg
    18901 ctgtgcaccc ctcgtacaaa gcgctcgcgc tcctcgttga ccaggaaggt cgcggcatag
    18961 gcacgggcga gggcactgta gagggcctcc tgctgagtgc ggtattccag gaccggcagc
    19021 ctgggcgcga gccgtcccat ggtggtgcgc ccgcgggagt agcgcagtgc gatggcgacg
    19081 gcggcccggg cggccgcggc ctggccggcg gccgcgccga ccgaggcgtg ggcggaggcc
    19141 gacagggagc ggaccaaccg gtggccgctg ccgtcgaggg ggtcctcgaa gcgtccgtcg
    19201 tcggtgatgt cggcgctgtc gcgcagccag ccgtcgtaag ggaccggggt gccgtcgaag
    19261 ctgatgacgg cgtagtcgag cgggacgagg gaagtgggcg gaagcggtgt gatgcggaca
    19321 ccgggcgccg tggtggcgcc gtgccgcagg cggacggcga acgggaagac gccgtgctcg
    19381 tggtcgtcga tgagcagtct ggcgtagacc acgacgatcc tggaccggcc gggcgcgccg
    19441 cccggcgcca tgaacttggc cgcctcgggg ccgggggtgt ggagggtgaa ggtacggttc
    19501 gcgtggtggt agcgggcttc ggtcgccgga ccgaggtggc tgctgccgtt gccgagttcg
    19561 gtgatgagga tgccgccgac ggcgtccatg gcgtcgaggt cctcgatgag gggcgcgagg
    19621 cccccgccgg gccgtccgag ctcgaccagg gtgcaggtga cgacggagaa gtggaccaga
    19681 gccgtgagga agagtccggg atcgaccgtc gcggcccatt cgagggcggt gagcagacgg
    19741 gatcggtcgt ggtgcagggc gagacttccg cctgcgtcga gcccgagggc acgcagcctg
    19801 ctgtacgtcc gctcgtgccg ggcgtcggcc gggccggtcg aggggctgcg gtcgaagcag
    19861 ggccggtcga gcaggcggtc gagacgggcg agatgacgca gacggtcgcc gtgcagcagg
    19921 cgccgcatcg aggtcggtcc ggacggcccc ggggcggggt ccgtcacgga gcggcctcct
    19981 gagcccctgg tgagacaaga atcggtgggc cgggcgggac gggatcggct gtaccggtct
    20041 gcccggcggg gtgcgccgag cgctccaggg tgcgcatggc ctgggcgtgt tcgatcgcga
    20101 agatgtgcgc ggggtcgaag gcgtgcaggc gcactcggca gctgacgcag acgcggccgc
    20161 tctgacggat cgtcacctcg gctgtcagtg ggacgcgatg gtcctcgggg ggtccggtca
    20221 cccgcagggt gccgtcgagt tcggcgggga gcgggaagac gaacctctcg aagtccgtct
    20281 ccagagcgtg catcacggca tagcggtcac cctggccggg agggggcgcg acgagctccg
    20341 cgacggccca ggtgatgagc tgtgtacatg cctcgatcag cagcatgccg gggacgtgct
    20401 gctgatcagc cgtgtggtca cggatcatct cggtttcgtt gggaacggtc aggcgggcgc
    20461 cgaaacggcc gtcggcggcc cgggcgtctc cgatgaggac gttgtcctgg gcgtgtttga
    20521 gcacgcgatg gcgcgggacg ggtctcgggg gccggtgggt gtccgcggga cgggcgtcgg
    20581 cctcggccat gctctcgcac aggtcggccc aggtgttctc gtcgatgccc aggcccggca
    20641 ccacggtggg ccggataccg ggctccgggg tgtgccgcgc gagccggtcg cgcagatccc
    20701 gtgcggtgac gacctggggg tggacggtgg cgcgggagaa ggattcccct accacccaca
    20761 ggatccgagg tgaggtcacg gtgttctcct gaagcaggcg cgaggcccac agcggtggct
    20821 cgcgtacgga aaggggaaga cgaacgatgg ccttctgggc ggatccacgc cgctgagccc
    20881 gggcgcgggc gggctagggg ccgtacgtgg ccgcgaggag cgggctgcgt gcgggtttcg
    20941 tggtgccgct ccacgtcagg accgtgctgc cccaggtgag tccggcgccg aacccgacca
    21001 gcagcacccg gtcacccgtc ttgatccggc cctcggccgc ggcgtgggcg aggccgaacg
    21061 gcagtgatcc cgcaccgatg ttccccaccc ggtccccgat caccaccagt cggtcgggat
    21121 cgatgcccaa ggactcgccc acgccgcgca gcaggaccgg gttcggctga tgcatgacca
    21181 ctacgtccac ttctcccagc gtcaggtccg cttgttcgag ggcggtcgcc acggccctgg
    21241 gaacgatgtc cacgatgaag tcgcggaccg cgtgcccgtc catgacgatg tggtgccccc
    21301 cgtcggcgag cgtggcgtcc gaggccggcc gccggctgcc accggccggg atgaggacgt
    21361 caccggcccg gcgcccgtcg gagccgagag cgatggcccc gaaaccctcg ccgacgggta
    21421 cgggacccat gacggtggcc gccgccccat cggcgaacag cacggccgtg gggcggtccg
    21481 cggcgtcgac gaacggcgag tagacctcgc agcccacgac cgcggcgtac cgtgcgcccg
    21541 ggtcgcccag gagccagtcg cgcgcgacgc gcgtggcgaa gagccagccc gagcaggccg
    21601 cggagacgtc gaaggccacg gcgttccgcg cgcccagcga cgcctgcacc cgacacgccg
    21661 tggaggggcc cagttcgtcg ggcgtggagg tggccaggac cagcaggtcc agctgctcgg
    21721 cggcgatacc ggcacactcg agcgcctcac ggaccgcttc ggcggcgagg tccgacgtcg
    21781 cctggcccgg ccctgcgatg tgccgccgcc gcacgccggt gcgttcgaga atccactccg
    21841 ggctgatccc ggtgcgggct cccacctcgg cgttcgtgcg gaccgtcggt gggaggaacg
    21901 cgcccgtccc cagaattccg atgcggtgtt ccatgtctga ctccccttcg gcagcctgcc
    21961 acgaagagtc gatcagcagc acgccgtgct cgccacccgg ctcatgccgg atgcggccat
    22021 ccggggcggg cgcccgggcc gggcggacca tcgtgcgggg cccggcggcg ggaggggaag
    22081 ccgccgatgc ggcttcccct ccttcggagc cctcgcgttg cgaacgcgtg cggccgaaca
    22141 cagcatggct aattgtcgat aaagaaattt ttatgctgag aggtcgatgt gagctccgac
    22201 gcctccggcg gtgtccaccg ctccgtcatc gtcagcctta tcggcaccac gttggtctgg
    22261 tacgacttct tcctgtacgt cagcgcctcc gtgttggtct tcaaccaccg gttcttcccc
    22321 tacctgacgc cgttcgccgg cacgctcatg tccgtggggc tctacggggt cggcctcgtg
    22381 gcccgtccgg ccggcggcgt gctctgcggc cacctcggcg accgtcacgg cagacgcccg
    22441 gccctggtgg ccaccctggt gctcaccggc gcctccaccg gactgatcgg cgtgctgccc
    22501 gcgtacgacc ggatcgggct cgccgccccg ctgctgctgg tggcgctgcg gttgctccag
    22561 gggctcggtc tcggaggcgc atggggagcc gcggccgtcg tctcgctgga atgcgtccca
    22621 ccggagcgcc gggggcgcat ctccagctgg gcccagaccg gggcgccggc agggaatctg
    22681 ctggccttcg gcatgatgac ggccgtatcg gcgtcgatga cgtccgaaca gttcgtgacc
    22741 tggggctggc ggctgccgtt cctgttctcg gcggtgctgg tggcggtggg gctgtgggcc
    22801 cgtatgcgca tcgaggagac ccccgtcttc cgggcgctgt ccgcggccgg cgcccgccgc
    22861 gagcggccgg tcgtcgagct ggtgaaggac caccggggcg gactgctgac cgccgtggcc
    22921 gtggcggtgg gcgcggacgt cgtgctgttc acgttctcgt tcggctacgt cctcaccttc
    22981 ctcaacatcg cgggagtgcc cttcaccgcc ctgttggccc tcacggtcct cagcccgctg
    23041 gctctgatcg cgctgatccc gctcttcggc ctcctgtccg accgctgcgg ccgacggcgc
    23101 gtctgcctgg caggcacggt ggccacagcg gtgtgggccg ccgggttcct tcccctggtc
    23161 cgcactgcct cactgccggt cctggtggtc gcgtacctgc tcgcgctggc ggccttcgcg
    23221 gcgatgtacg cacctcaggc ggccatcgtc gccgggctct tcccgagcca cctcaggctc
    23281 agcggcacca cgaccggata ccagctggcc ggtctcctgg ggagcacgct cgccgccttc
    23341 ctgaccaccc gggcagccgg ctggttccac acccccgccg ccgtccccgc ctatgccctc
    23401 gccgccctcc tggtcagcgg cggggcactc ctgatcaccc gccacgcccc cgaaggagca
    23461 gacacatgaa acgtccctgg cgactcccgg tcgttgtcgc ggtcggcgcc ctcttcacgg
    23521 cactcgccct ctacgacgtc tcgtccgcgg gtgcacccac cgtcatcacc tgcgacaaca
    23581 catggacgat gaacttcact ccggccctga ccgtcgcgtc gcaggacaaa gtgacggcca
    23641 aggtcagcga tccgaacggc gcactgcgca agtgcaccgg tgatgccgcc atgaccatgg
    23701 gcgacttcgt ggccgaaggc atcggcaaca gcgtgacctg cgccgccggc agctacgaga
    23761 acacatccag cgcgctgcaa cgtgtcacct ggaacgcccg ggacaaccag ctcaccagca
    23821 cctacacctg gaacatgagc cccatcggag acctgctcag cgcccagtcc cccctcaacg
    23881 gcgggatcac cgagggtcgg tacaagggcg ccacctggac catggccatc gacccgatcc
    23941 gatccaagat cagcctcacc gactgcgaca gccccaccgg actgaagtcc atcagcgtcg
    24001 ccggcaccct ggtcatcacc cccgcctcat gagcccgacc gtggcggagc agtgacttga
    24061 ggggtcgggc tgccggctgt cagtcctgct gcctcgggtt ggtgagggcg tgaagtgtgc
    24121 ccgtgagctg gtcgggggtg aggggcgggg cgggcagggg ggccgcggcc tcggcgcgca
    24181 ggccggcgag gaggaggtgg agatggcgcg gccaggcgcc gggggcggtg gcttcggagg
    24241 cggggaccac ccgtccgagg gcggcgagca ggaagagcag gtcctcgacg gtgacgtcgg
    24301 ctcgtacggt gccctgtttc tgggcccggc cgatgagctg ggtcatggtc tggtggtggt
    24361 gggccttgag ggcgtcgagg gaggggatgt cggggatgct ggtggtcatg aggtcgttgg
    24421 cgccccggtc ggcggcgaga ccttcgaaga tgccctcgag gtagtggacc aggccgtccc
    24481 aggcgtcctc ggcgccgcgg gcgttctcac cgtggcggag ggtgtcgttg agcgactcgc
    24541 cgaagaccgc ttcgatgagc gctccgcggg tggggaagcg gcggtagagg gtggcgttgc
    24601 cgactccggc gcggcgggcg atgtcgtcga ggggggcgtc catgccttgt tcggcgtaga
    24661 tctcgcgggc ggcggcgatg agcagttcgc ggttgcgccg ggcgtcgcgc cgcagcggcg
    24721 cggggcggct gttcccggcc ggcggcccgc ctgacccgcc gcttcgcgca gtgctcactg
    24781 tccctcaact cccgtgccgt gcgccgatgc tgtccccggt gctgttctcg ctgtcgcggg
    24841 cagcagccta gcaagaaagc gtggactgct ccccggttcg ttgttagggt cgggacatca
    24901 agtggggagt gctccccact tgatggggcc atggcctgcc catggccatg ccctgacgac
    24961 gaaagggacg acagcccgtg agcaccatgc ccgcgttcga gactcttgca ccggccggca
    25021 ccgacttcac cgccgacccc tatcccgtct acgcccatct gcgggagcag ggcccggtcc
    25081 accgggtgcc cactggaggc tccgacgaca tctgggtgat cctgggacac gaggaggtac
    25141 gggccgcgct caccgatgtg cggctgagca acgacgtccg caactcctcc cgctgggtgg
    25201 acgacggtgg ttatgccatc ggccgcaaca tgctccagac cgacgcgccc cagcacaccc
    25261 gcctgcgcag gatggtcgcg ggggcgttca ccgcccgccg gatcgagtcg ctgcggccgc
    25321 gtatccagca gctgaccgac gaactcctcg acaagatcgc cccgttgacc ggtgccgatc
    25381 tcgtcgccgc tctcgcgcgg ccgctgccca tcgcggtgat ctgcgagctc ctgggtgtgc
    25441 cggccgagga ccaggagccc ttccgcgtct ggtccgacgc gatggtcttc cagcccaccc
    25501 ccgaggccgc ggccgccgcg gccatgtcga tgaccgagta cctgagcggg ctgctccagg
    25561 ccaaggaccg ctccccgggt gacgacctgc tcagcgcgct ggtccgcgcc cgcgacaccg
    25621 acggtgaccg cctgggtccg gaggagctcc tcggtatggc gttcgtgctc ctcgtcgcgg
    25681 ggcacgagac caccgtcaac ctcctgtcca acggcacgta cgccctgctg acccaccccg
    25741 agcagctcgc cgcgctgcgc gccgaccggt ccctgctcg
//
