LOCUS       NZ_CP031455            22485 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces olivoreticuli subsp. olivoreticuli strain ATCC 31159
            chromosome, complete genome.
ACCESSION   NZ_CP031455
VERSION     NZ_CP031455.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivoreticuli subsp. olivoreticuli
  ORGANISM  Streptomyces olivoreticuli subsp. olivoreticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Complete genome sequence of Streptomyces olivoreticuli ATCC 31159,
            producer of anticancer bestatin and diverse secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2018) Tianjin Key Laboratory of Food
            Biotechnology, College of Biotechnology and Food Science, Tianjin
            University of Commerce, NO.409 Guangrong Road, Tianjin, Tianjin
            300134, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-JUN-2018
            Assembly Method                   :: SMRT Link v. 5.1.0
            Assembly Name                     :: TJCU_BT_311
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: SMRT Link v5.1.0
            Genome Coverage                   :: 145.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003391135.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 04:49:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,562
            CDSs (total)                      :: 7,459
            Genes (coding)                    :: 7,276
            CDSs (with protein)               :: 7,276
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 183
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 183
            Pseudo Genes (frameshifted)       :: 61 of 183
            Pseudo Genes (incomplete)         :: 150 of 183
            Pseudo Genes (internal stop)      :: 18 of 183
            Pseudo Genes (multiple problems)  :: 41 of 183
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:12:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8074860
            Orig. end                         :: 8097345
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Hongyu Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22485
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="41"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22485
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22485
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12485](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12485
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(732..1625)
                     /locus_tag="DXZ73_RS35060"
     CDS             complement(732..1625)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568141.1"
                     /locus_tag="DXZ73_RS35060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_240351628.1"
                     /transl_table=11
                     /translation="MKQPSVRVRTHRAASPWLFLIPGLGVIAAFNLYPFLTTVRKAFTD
                     ARTLTPGSWVGLRNFQDMLDDDQFWVALRNSGLYVLLVVPFTVLLPLLLALLVHKRLPG
                     VTFFRSAFYTPVVASVVVVSLIWVWMLDDRGLINGILRFFGAGPVAFLGDEWLLLFSAM
                     ALTVWKGLGYYMIIYLAALADVPRELHEAAAVDGAGALRRFVSVTVPALRSTMVLVGAL
                     SSVAAFKVFSEVYLLAGPTGGPAGQDTTLVMLVQRTGTGLSGRVGYASALSLVVFVIAL
                     LLMLLVLRADRKESAS"
     gene            complement(1631..2923)
                     /locus_tag="DXZ73_RS35065"
     CDS             complement(1631..2923)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092452.1"
                     /locus_tag="DXZ73_RS35065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_116214961.1"
                     /transl_table=11
                     /translation="MPRSRRTAAAAPLLASALLLTACGSGGGSDGGAADGKAAGSITFQ
                     TWNLRSNFKDYFEGLVGEFEKQNPDVKVKWLDQPADNYAEKLSADAGGGTLPDVVNVSP
                     DLSYPLAKAGILLNLDREKAAAKFKDEYTPEAWQGNTLPGLDGSYAFPWYLNTGPLFYN
                     KALFRQAGLDPEKPPKNYDELFTTADALAKRSGGRTATLAGTPSIEDFGRYGVRLMNAD
                     ATKFTYNEPKGVELLTKYKELYAHGGLDSQALTNTADQSGQKFLEQKVAINPGSAHDLD
                     TFKKNAPGLYKELGITDAPNNTGKPNMYVMGLAVNKQSKHKAAAVALAHFITDRKNQED
                     FAHKVAVFPSTKGSLDDPYWTKDDGTDEGRVRVASAKMLKGAVNYTPVVLSEEMKVVLK
                     NEVAKALQGRKSPQQALDDAVAQSDKLLKQS"
     gene            3100..4137
                     /locus_tag="DXZ73_RS35070"
     CDS             3100..4137
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151474.1"
                     /locus_tag="DXZ73_RS35070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_116214962.1"
                     /transl_table=11
                     /translation="MRRTPARRPTMKDIARRAGVSESAVSFALNGRPGVSDATRERVRQ
                     VAEQLGWQPSTAARALSGEGAATVGLVLARPARTLGAESFFLQLVSGVQEVLADHRLGL
                     LFQMAEDIDAECAAYRRWWAERRVDGLLVVDPRADDPRPALLDELGLPAVVIGALDGDD
                     GAYGAISTLWADDTGAMASIVGHLHALGHRRITHVAGLPELAHTRRRMACLRTEAERRG
                     LPDATSVTTDYSDAQGAEATRRLLSGPQPPTAIVYDNDVMAVAGLAVAAERGVSVPGEL
                     SIVAWDDSVLCRSTHPSLTALTRDTPAFGRQAAHLLTALLAGAPPTRVQASTPRLTTRE
                     STSWT"
     gene            4266..5264
                     /locus_tag="DXZ73_RS35075"
     CDS             4266..5264
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0003960 - NADPH:quinone reductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_function="GO:0070402 - NADPH binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (17-324). E-value: 8e-54. Score:
                     174.8. Matches aSDomain:
                     nrpspksdomains_DXZ73_RS35075_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720737.1"
                     /locus_tag="DXZ73_RS35075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADPH:quinone oxidoreductase family protein"
                     /protein_id="WP_116214963.1"
                     /sec_met_domain="ADH_N (E-value: 2.6e-06, bitscore: 26.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-28, bitscore:
                     98.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAWRVHTNGEPRDVMRLEDVPDPRPAPGEALIRVLAANVNFPDA
                     LLCRGQYQVRPPMPFTPGVETCAEILALGEGAEGTVGARVLAQPALPAGGFAELAVVDA
                     KTLLPAPESLDDAEAAALHVGYQTGWFGLHRRARIRPGETLLVHAAAGGVGSAAVQLGK
                     AAGATVIGVVGGADKAREAHENGCDVVIDRRAEDVIGAVKDATGGHGADVVYDPVGGDA
                     YTQSTKCVAFEGRIVVVGFASGRIPSAALNHALVKNYTILGLHWGLYNTKDPAAVRACH
                     DELTKLAAQGAIRPLVSERLPLTAAADAVQRVADGTTTGRLVVVPAQEGPR"
     aSDomain        4317..5237
                     /ASF="ER domain putatively catalyzing 2S-configuration
                     product formation"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DXZ73_RS35075_PKS_ER.1"
                     /evalue="8.00E-54"
                     /label="DXZ73_RS35075_PKS_ER.1"
                     /locus_tag="DXZ73_RS35075"
                     /protein_end="324"
                     /protein_start="17"
                     /score="174.8"
                     /tool="antismash"
                     /translation="LEDVPDPRPAPGEALIRVLAANVNFPDALLCRGQYQVRPPMPFTP
                     GVETCAEILALGEGAEGTVGARVLAQPALPAGGFAELAVVDAKTLLPAPESLDDAEAAA
                     LHVGYQTGWFGLHRRARIRPGETLLVHAAAGGVGSAAVQLGKAAGATVIGVVGGADKAR
                     EAHENGCDVVIDRRAEDVIGAVKDATGGHGADVVYDPVGGDAYTQSTKCVAFEGRIVVV
                     GFASGRIPSAALNHALVKNYTILGLHWGLYNTKDPAAVRACHDELTKLAAQGAIRPLVS
                     ERLPLTAAADAVQRVADGTTTGRLVV"
     CDS_motif       4689..4748
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DXZ73_RS35075_0001"
                     /evalue="7.30E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="DXZ73_RS35075"
                     /protein_end="161"
                     /protein_start="141"
                     /score="24.8"
                     /tool="antismash"
                     /translation="GETLLVHAAAGGVGSAAVQL"
     gene            5261..6463
                     /locus_tag="DXZ73_RS35080"
     CDS             5261..6463
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105041.1"
                     /locus_tag="DXZ73_RS35080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_116214964.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.7e-11, bitscore:
                     42.1, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.5e-19, bitscore:
                     68.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6.5e-18, bitscore:
                     64.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAPVAATPGAGELRDRVAALLAAHDPASTDRLGFLRARFDAGLA
                     WIHFPEGLGGLGAPRSLQPVVDAALDAAGAPGNDPRRIGIGLGMAAPTILQYGTDEQKQ
                     RFLRPLWTGEEVWCQLFSEPGAGSDLAGLATRAVRDGDSWTVDGQKVWTSSAHLARWAI
                     LIARTDPDVPKHQGITYFVCDMTDPGVEVRPLRQITGEAEFNEVFLTGVRIPDTHRLGA
                     IGDGWRVAQTTLMNERMAIGGTRVPREGGMVGVVARTWRERPELRTHDLHQRLLRLWVD
                     AEAARLTGERLRQQLRRGRPGPEGSGMKLAFARLNQELSALEVELLAEDGLTYGDWTMV
                     RPELVDFTGRDAGYRYLRAKGNSIEGGTSEVLLNIVAERVLGLPPEPRNDKDLPWKDLP
                     R"
     gene            6460..7590
                     /locus_tag="DXZ73_RS35085"
     CDS             6460..7590
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009720739.1"
                     /locus_tag="DXZ73_RS35085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_116214965.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2e-10, bitscore:
                     40.1, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5.6e-29, bitscore:
                     100.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPDLLYSETEQDLRAAVRSLLAAHGAPASVLAGAESGRPYDTGL
                     WQSLAVGMGTAGLLVPEKSGGQGATAREAAVVLEELGRTVADVPYLTSAVLAVRTLLGC
                     DTGRTEVAAPLTALAEGRQVGALAVPLPTAPGAGVRPTVSAEPTGPDRALLTGTVNAVA
                     GAAGADVLLVPTDTGLHSVDPTAEGVTLTPLTPLDLTRPIARITLSAAPAALLAGPDRA
                     RTALDAALLTGAGLLASEQLGVAEWCLTETVRYAGERQQFGRPIGSFQALKHRLAALWL
                     DIASARATARNAADALATDAPDAAIAVAVAQSCCSEVAVRAAEECVQLHGGIGMTWEHP
                     AHLYLKRARTDATALGTPDRHRQALARLADVPGPVA"
     gene            complement(7597..8124)
                     /locus_tag="DXZ73_RS35090"
     CDS             complement(7597..8124)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031671.1"
                     /locus_tag="DXZ73_RS35090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_116214966.1"
                     /transl_table=11
                     /translation="MTELRTARLALRPWREADLAPWAAMNADPEVREHLGPVLSREQSD
                     ASVARFRTEFEERGFGWWAVEVLATGEFIGFAGLDEVDDGMPFTGVEIGWRLARPSWGH
                     GYATEAARAALDFGFGTLGLPEILGVTTVTNLRSRAVMSRIGMTRDPADDFDDPSAPEG
                     PLRRNVVYRIRA"
     gene            complement(8195..8461)
                     /locus_tag="DXZ73_RS35095"
     CDS             complement(8195..8461)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570382.1"
                     /locus_tag="DXZ73_RS35095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_240351629.1"
                     /transl_table=11
                     /translation="MAEIEGLYAALHATANGQRRERLLTELAQAGRRLTDLALVPQGER
                     VGVQPRSRWQRRRFLAARGAARIMAFATDRGRAGGPAPLEDSR"
     gene            complement(8750..8980)
                     /locus_tag="DXZ73_RS35100"
     CDS             complement(8750..8980)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004940895.1"
                     /locus_tag="DXZ73_RS35100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_116214968.1"
                     /transl_table=11
                     /translation="MTHDGMAEWETAVLEGGPVDGVVIRLANRPGVVQVTHPCAVEGPA
                     SEMHIAALYVYRRDLRVKEEPLRYGFDPASP"
     gene            9179..9445
                     /locus_tag="DXZ73_RS35105"
     CDS             9179..9445
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007380038.1"
                     /locus_tag="DXZ73_RS35105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_116214969.1"
                     /transl_table=11
                     /translation="MGIIGWIILGLLAGAIAKILLPGRDPGGLIGTTLIGIAGAFIGGW
                     LSAKFLHKPISNHFFDAATWGSAIAGSLVLLIGYRIFFGNSRD"
     misc_feature    9505..9519
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.5"
                     /tool="antismash"
     misc_feature    9601..9617
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.7"
                     /tool="antismash"
     gene            9710..9865
                     /locus_tag="DXZ73_RS38545"
     CDS             9710..9865
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS38545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162890451.1"
                     /transl_table=11
                     /translation="MVNNERMESRELQAYEAPEMFECGSFQEETGMLGTAGQEPFVPAL
                     HTHWGW"
     gene            10001..11752
                     /locus_tag="DXZ73_RS35110"
     CDS             10001..11752
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="DXZ73_RS35110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_162890452.1"
                     /sec_met_domain="Asn_synthase (E-value: 9.8e-33, bitscore:
                     113.0, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHRSGRPWVAGRLAPGQILLAEHGDTRLAVIGQCSASAAELTAT
                     AAKVHEPHHLDRLGTDWAGSFHLIALIDGRVHIQGSASGLRRVFHGRLGALNLAADRAD
                     TLAALLDAPFDRSALALRLLVSVPHPLTDRTPWQNVTAVPPGSRLTLSSDGRQQAVTPW
                     WRAPEPVLSLEDGAAALRQALETAVRVRSDGARTITADLSGGLDSTSLTVLAARERASL
                     TVFTMENPDEADEDLRWARTAAAHLPQLNHIVYPADRLPGFLGGLVGADGAPLPVDVLP
                     DEPSSAVVSAPRMRAAKEMATAHGSRLHLDGFGGDQLLTGHPGYEHDLLRSRPLLTLKR
                     LHTLHELTGFRWSPALRDLLDSRSYRHWLATETAALTRRRPPRPQNSAFAWGGTLQLPR
                     WLTPEAGDLIARTLRHAARTAQPLAAARGRHGDLLEIQNTGRMIRQLHQVVATPDFTPA
                     SPFLDDQVIHACLAVRPDERVTPWELKPLIKAALADVLPRELLTRRTKGDGALIAAEGF
                     ERHRRDIAGLWDSSALAELGLIDPEPLRALFRRPYSPRLHERAMPTTIGCELWTRAARR
                     APAAART"
     aSDomain        11806..11967
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DXZ73_RS35115_Lasso_Fused_RRE.1"
                     /evalue="8.10E-09"
                     /identifier="RREFam003.1"
                     /label="DXZ73_RS35115"
                     /locus_tag="DXZ73_RS35115"
                     /protein_end="54"
                     /protein_start="0"
                     /score="26.5"
                     /tool="antismash"
                     /translation="MTLRLRPDVSTADTEYGTVLLDGAGGRYWQLNGSASVALRVLLEG
                     GTAEQAAQR"
     aSDomain        11806..12054
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DXZ73_RS35115_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.80E-25"
                     /identifier="RREFam002.1"
                     /label="DXZ73_RS35115"
                     /locus_tag="DXZ73_RS35115"
                     /protein_end="83"
                     /protein_start="0"
                     /score="78.7"
                     /tool="antismash"
                     /translation="MTLRLRPDVSTADTEYGTVLLDGAGGRYWQLNGSASVALRVLLEG
                     GTAEQAAQRLTATYDVDESRAREDVERLRVRLIDAKLV"
     gene            11806..12063
                     /locus_tag="DXZ73_RS35115"
     CDS             11806..12063
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004949363.1"
                     /locus_tag="DXZ73_RS35115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_116214971.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1e-22,
                     bitscore: 78.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 2.2e-06,
                     bitscore: 26.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.7e-10, bitscore: 39.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRLRPDVSTADTEYGTVLLDGAGGRYWQLNGSASVALRVLLEG
                     GTAEQAAQRLTATYDVDESRAREDVERLRVRLIDAKLVLR"
     gene            12060..12485
                     /locus_tag="DXZ73_RS35120"
     CDS             12060..12485
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004949361.1"
                     /locus_tag="DXZ73_RS35120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_116214972.1"
                     /sec_met_domain="PF13471 (E-value: 4.1e-26, bitscore: 90.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAVVPHRVRPRLSPGRRLLTLLAVAVAGRLARSSPARIRTVLTW
                     LRKGARPAAYAEVRAARQAVVVVSLRCASDEGCLQRSLATVLLCRVRGSWPEWVVGVRA
                     RPPFGAHAWVEAEGRMVEEEADPSYFRRLFSVPAAER"
     gene            complement(12520..13485)
                     /locus_tag="DXZ73_RS35125"
     CDS             complement(12520..13485)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="DXZ73_RS35125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_116214973.1"
                     /transl_table=11
                     /translation="MIITFKPLSTTDARDLAALRDEVERADRTGRHEDEADVLHELADP
                     KLDLAHNTAGLWRGSRLVAYAMVYEPEQVRDIARFGTAAAVHPDWRRQGIGARLVDWMR
                     DRADAIRAERHPGVPGELLVDGSTTNAGLAALALHAGFEPRRYWFSMTHDLRTDRLPAV
                     KVPDGLRLAPFEAALDEATRSAHNDAFRDHWNHTETDRADWETWFTGDRSFRAALSALL
                     LDTDGRVAAYLLADEYVADGTATGHRSCTIGHLGTRPAHRGRGAARALLAHTLTEAGHQ
                     GYDKAELVVDAANPTGALGLYERMGFVTEREFVTYARPLG"
     misc_feature    complement(13470..13484)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.26"
                     /tool="antismash"
     misc_feature    13875..13890
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.84"
                     /tool="antismash"
     gene            13880..14164
                     /locus_tag="DXZ73_RS35130"
     CDS             13880..14164
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669318.1"
                     /locus_tag="DXZ73_RS35130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_116214974.1"
                     /transl_table=11
                     /translation="MSDQAWTIESICEALGNPALSQRFLGEINRAPAHELLTVFAKWRT
                     IAAGVSVAAERGRMLAEAEAVAGEIPGDWVDMTDRVQAEAAAARGRGAA"
     gene            14164..14415
                     /locus_tag="DXZ73_RS35135"
     CDS             14164..14415
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537390.1"
                     /locus_tag="DXZ73_RS35135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_116214975.1"
                     /transl_table=11
                     /translation="MVYRLKYDLAAEAVHDALPPEASERLSLALAAACDDPIASTEPYG
                     EDDGVVRMIVTEHVIGVLLALIHRRGLGSDLVTGFEPV"
     misc_feature    14353..14355
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14527..15918)
                     /locus_tag="DXZ73_RS35140"
     CDS             complement(14527..15918)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010991835.1"
                     /locus_tag="DXZ73_RS35140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS1380 family transposase"
                     /protein_id="WP_116209103.1"
                     /transl_table=11
                     /translation="MQVSHTPAAVSAVFDDPNLIAHAGLVPVMRLAGRCGLPRLVTEKV
                     RLTGAKNGAGAAADAKVTSIVAGMAAGADSIDDLGALRHGAMPTVFRGIRAPSTLGTFL
                     RSFTHGHALQLHAVHRRFLAELAAHTPLLPGSDEKAFIDVDSTHKRVYGRAKQGAEYGR
                     FKGIRTLHPLLATICTPASRPVIATVRMRRGKAADSRGAPKLVSEALATAVEAGCTGMR
                     ILRADSQFYNAGVIAACRRAGAHFSVTTGMNPSIKRAIHSIPDTAWQQITYPTAVPDPE
                     TGDLIPDAEVAEIPVYAAFVSRRKASRVTARLIVRRVRDLAKPATVGEQGELFPVWRYH
                     PFFTDNPARTLQAEQEHRHHAVVEQVIADSKASALAHLPSGHFHANSAWLTLWAMTCNL
                     LRAAGALASAFHAKATTATLRTHLVQVPARIARSARRITLHLPHNWPWQHAWTHLFDTV
                     HGPPG"
     misc_feature    complement(16546..16559)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.33"
                     /tool="antismash"
     misc_feature    complement(16549..16565)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 20.78"
                     /tool="antismash"
     gene            16719..17096
                     /locus_tag="DXZ73_RS38550"
     CDS             16719..17096
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS38550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162890453.1"
                     /transl_table=11
                     /translation="MRQQDRQDCKEALREFFDIAAKHWNITCRMAEVKSKARRLALQSE
                     MEEVDERLSAIRSGIDILSGASVMDAIARYVDALRVERDNAWNGRKVEKSVCDEPYVAA
                     VECTRSLLRFADVAPNGVKRM"
     gene            complement(17142..17297)
                     /locus_tag="DXZ73_RS40320"
     CDS             complement(17142..17297)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020694.4"
                     /locus_tag="DXZ73_RS40320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_338059165.1"
                     /transl_table=11
                     /translation="MRETVSALSERCLPAEPTEAAAVVIDRWADTKDLSLEISEALGWL
                     HKIPED"
     gene            17366..17680
                     /locus_tag="DXZ73_RS39790"
     CDS             17366..17680
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS39790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162889884.1"
                     /transl_table=11
                     /translation="MYDPRHIEQLVLDTVIPGKRVRDSGEYAARLPECAVRHSKGKVAD
                     RPLVRSVGREVSALQRHYAVPQFVNFATQLVDFLPQLFDSCLGGVRSGEARRVWRQEGA
                     "
     gene            17972..18175
                     /locus_tag="DXZ73_RS39795"
     CDS             17972..18175
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS39795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_240351630.1"
                     /transl_table=11
                     /translation="MSQQISPRGTFLKVADAVRAQIESDLEMAELPSAAEVVRAHGVSR
                     GVGLRAFGVLREEGLAKPAPGG"
     gene            18528..18737
                     /locus_tag="DXZ73_RS39800"
     CDS             18528..18737
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014069.4"
                     /locus_tag="DXZ73_RS39800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HD domain-containing protein"
                     /protein_id="WP_240351631.1"
                     /transl_table=11
                     /translation="MAERARTIAPLLGEDAELLEAAAVLHDVGYAPDLAQTGFHSLDGA
                     RYLRGVAHADERSCACWCTTCVRG"
     gene            18701..18937
                     /locus_tag="DXZ73_RS39805"
     CDS             18701..18937
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS39805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_240351632.1"
                     /transl_table=11
                     /translation="MRLLVHHLCAWMKAEARGLRDELESEFPRGRPHLIDALCYCDMNT
                     TPDGTATNPVDRVNEIAGRYGPGSLIDKFIRRR"
     gene            complement(18995..19467)
                     /locus_tag="DXZ73_RS35160"
                     /pseudo=""
     CDS             complement(18995..19467)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179186.1"
                     /locus_tag="DXZ73_RS35160"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGRIDYLHDPDAPPANSVVPSVVAFVQNDEGQVLMIQRSDNGRWA
                     LPGGGHDAGEFVSDTVCARSEKKPASRSRSSTCPGSTPIRDMSWPTTTERSGSNSASAF
                     GPGRSAGKFVRATRRHRSAGSIRRTCRRTTSTRPCDSGSSTPWTGRGQRPISA"
     gene            <19588..19713
                     /locus_tag="DXZ73_RS39810"
                     /pseudo=""
     CDS             <19588..19713
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638234.1"
                     /locus_tag="DXZ73_RS39810"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="EVIARVVGYSGTATTERVYRKQLRPVITEGAEAMDEIFGGG"
     misc_feature    19831..19849
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: medium, score: 29.05"
                     /tool="antismash"
     misc_feature    complement(19832..19848)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: medium, score: 27.64"
                     /tool="antismash"
     misc_feature    complement(19834..19849)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.9"
                     /tool="antismash"
     gene            19881..21467
                     /locus_tag="DXZ73_RS35175"
     CDS             19881..21467
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018836194.1"
                     /locus_tag="DXZ73_RS35175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_116214976.1"
                     /transl_table=11
                     /translation="MTARSVRGVAAAAMAGVLAAGAAACSTPGGGGEDKESLVVGLANE
                     PETLSPLLGYGKDGNSKIFDGLLRRDADMKLRPALAAALPAVADDGKTYTYKLRHGVKF
                     SDGKPFSAKDVVFTYRTILDEKTNNAAKGELDAIDAVTAEGDDTVVFTLKYPYAPFAER
                     TVLPIAPEHAAKGQDVNTGSFNTAPIGTGPYVLTGWSKGEKLSFKANPGYWGGEPKIKK
                     LTMAIIKDDDVRATRLRSGDLDGAILPPNLAKGFKGDKSKLSVTARTTDFRGVTLPTAN
                     KVTGDIAVRRALDLAVDRKAMVDKLLEGAGKAGYGPVPTDSEWFAKGTERPYDLDKAKK
                     LLDDAGWKTGDGGIREKDGQRAEFTLWFPAGDKLRQEHALAFASDAKKAGLKVEVQSGT
                     WEVIEPRMKNDAVLAGGGNPADPDFDLYNLLHSSLALDGFNNMAAYVDPEVDKALEEGR
                     RSGDRTARKAAYDKVQRGLADNPGYTFLTHVDHLYVMNDEWQDITTQVEPHDHGLGAGP
                     WWNVESWQPKK"
     gene            21509..22465
                     /locus_tag="DXZ73_RS35180"
     CDS             21509..22465
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542957.1"
                     /locus_tag="DXZ73_RS35180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_205519401.1"
                     /transl_table=11
                     /translation="MAGRRLLAAVPVLAAVTFGVFAIAAASPFDPAQAYAGSAGLSAGQ
                     GVLDQLRENLGADRPFAVRWWDWITAALTGDLGDSSSLRQPVAQVIGERVGWSVLLCAV
                     AFALALAVGTALGVLAARRRGGLFDRAVTSVAYALEAAPPFWLGLLAIWLFALKLDALP
                     AGGLTDTGSDAATPGQIASHVVLPAVVLAVSQLPWFVLYVRQGVGDALEEDPVRGARAR
                     GLRERTVLLHHALRSGLLPVLTLIGSRVPELITGALLVETVFSWPGIASATVEAATKVD
                     FPLLAALTVLATAAVLVGNLLSDLLYGLADPRVGFDG"
ORIGIN
        1 cgcggcgacc agccgggggt tctgctgaaa cgttccgtgc aggtagttca ggccgacggt
       61 cagggtgaag tggtccgagt cggagaggac gatcagcggc cagaggaagt cgtcccaggc
      121 gcccatgaag gagaagatcg ccacgacggc cagggtgccg cggacggagg gcagggcgat
      181 ccggaggaac cgctgccata cgttcgcccc gtcgatgacg gccgcttcct cgatctcgta
      241 cgggaggttc gcgaacgcgt tgcgcatcag cagcacattg agcgcgccga ccgcgccggg
      301 cagcaccacg gcggtgaggg tgttgttgag gtggaggtcg cgcatcatgg tgaactgcgc
      361 gatgacgacg gactccaggg ggacgagcag ggcgaccacg aaggcgagtc cggcgagccg
      421 ccggccgcgg aagcgcagcc gggccagtgc gtatccggcc agggaagcac cgacaaggtt
      481 ggtgaccaca ttggtgaggg cgaccttgag ggagttcagc gcgtagtccc agaccgggat
      541 gatgtcggcg acacctgaat aatttccgag agtcggatgc tcgggcagga accccggcgg
      601 gtaggtgtag atgtcctcgg aggcgccctt gaacgaggtc gacagctgcc acaggaacgg
      661 cccgacggtg atgcccagca cggcgagcat cagcagatag cgcagcgcct tctcccagcc
      721 ggagatccgg gtcacgacgc gctctccttc cggtcggcgc ggagcaccag cagcatcagc
      781 agcagggcga tcacgaagac gaccagggac agggccgagg catagccgac acggccgctc
      841 agcccggtgc cggtccgctg gacgagcatg accagcgtgg tgtcctgccc ggccggacca
      901 ccggtgggcc ccgccagcag atagacctcg gagaagacct tgaaggcggc caccgacgac
      961 agggcgccga ccagcaccat cgtggagcgc agggcgggga cggtgacact gacgaagcgg
     1021 cgcagggcgc cggccccgtc gacggcggcc gcctcgtgca gctcccgggg gacatcggcg
     1081 agcgccgcca gataaatgat catgtagtag ccgaggccct tccacaccgt cagcgccatg
     1141 gcgctgaaca gcagcagcca ctcgtcgccg aggaacgcca ccgggccggc cccgaagaag
     1201 cgcaggatgc cgttgatcag cccgcggtcg tccagcatcc agacccagat cagcgacacc
     1261 acgacgacgg acgccacgac gggggtgtag aacgccgacc ggaagaacgt gactcccggg
     1321 aggcgcttgt ggaccagcag cgccaacagc agcggcagca gcacggtgaa gggcacgacc
     1381 agcaggacgt acagcccgct gttgcgcagc gccacccaga actggtcgtc gtccagcatg
     1441 tcctggaagt tccgcagccc cacccagctg ccgggcgtca gcgtccgcgc gtcggtgaac
     1501 gccttccgga cggtggtgag gaaggggtag aggttgaagg cggcgatcac cccgaggccg
     1561 ggaatcaaga agagccaggg gctggccgcg cggtgggtgc gtacgcgtac ggagggctgc
     1621 ttcacggccg tcagctctgc ttgaggagct tgtcgctctg tgccacggcg tcgtccagtg
     1681 cctgctgagg ggatttcctg ccctggaggg ccttggcgac ctcgttcttc aggacgacct
     1741 tcatctcctc gctcagcacc accggcgtgt aattgaccgc gcccttgagc attttcgccg
     1801 aggccacccg gacccggccc tcgtccgtcc cgtcgtcctt ggtccagtag ggatcgtcca
     1861 gcgaaccctt ggtgctgggg aagacggcga ccttgtgcgc gaagtcctcc tggttcttcc
     1921 ggtccgtgat gaagtgcgcc aaggcgacgg ccgcggcctt gtgcttgctc tgtttgttga
     1981 cagccaggcc catcacgtac atgttcggct tgcccgtgtt gttcggggcg tcggtgatgc
     2041 cgagttcctt gtacagaccg ggcgcgttct tcttgaacgt atccaggtcg tgggcgctgc
     2101 ccggattgat ggcgaccttc tgctccagga acttctgccc cgactggtct gcggtgttgg
     2161 tgagcgcctg cgaatcgagc ccgccgtgtg cgtagagttc cttgtatttg gtgagcagtt
     2221 cgacgccctt gggttcgttg taggtgaact ttgtggcgtc ggcgttcatc agccgcacgc
     2281 cgtagcggcc gaagtcctcg atggacgggg tgcccgcgag ggtcgcggtc ctcccgccgg
     2341 accgtttcgc cagggcgtcg gccgtggtga acagctcgtc gtagttcttc ggcggcttct
     2401 ccgggtcaag acccgcctgc cggaagagcg ccttgttgta gaacagtgga ccggtgttga
     2461 gataccaggg gaaggcgtac gaaccgtcca ggcccggcag cgtgttcccc tgccaggcct
     2521 ccggcgtgta ctcgtccttg aacttcgctg cggccttctc ccggtccagg ttgagcagga
     2581 tcccggcctt ggccagcgga taggagagat ccggcgaaac gttgacgaca tcgggcaggg
     2641 tgccgccacc ggcgtcggcg ctgagtttct ccgcgtagtt gtcggccggc tggtccagcc
     2701 atttgacctt gacgtccgga ttctgcttct cgaattcccc gaccagaccc tcgaagtagt
     2761 ccttgaagtt gctgcgcaga ttccaggtct ggaaggtgat gctgcccgct gccttgccgt
     2821 ccgcggcacc gccgtccgaa ccaccgccgg aaccacaggc ggtgagcaac aaggcggacg
     2881 cgagaagcgg ggcggcggca gcggttctac gggaacgggg catggcgcgg cgaactcctt
     2941 cggtcggacc gggaggtgcg caacaaaagc tgcacccgcg gcgcggtgaa gtcaatactt
     3001 ccgctgccga ctaatgcgct ttagcctgcg gggagttacg gtcgatcgag tgcttcggca
     3061 cggacccgcg tcccgggcgc gggcagcgga aggagagcca tgcgccgcac cccggcccgc
     3121 cgcccgacga tgaaggacat cgcacgccgc gcgggtgtct cggagagcgc ggtctccttc
     3181 gcgctcaacg gccgccccgg ggtctccgac gccacccgcg aacgcgtgcg ccaggtcgcc
     3241 gaacagctcg gctggcagcc cagcaccgcg gcccgcgccc tgtccggcga gggggcggcc
     3301 acggtcgggc tcgtcctggc caggcccgcc cgcaccctgg gcgccgagtc cttcttcctc
     3361 caactggtct ccggcgtcca ggaagtgctc gccgaccacc gcctcggcct gctcttccag
     3421 atggccgagg acatcgacgc cgagtgcgcg gcgtaccggc gctggtgggc cgagcgccgc
     3481 gtcgacggac tgctcgtcgt cgacccccgc gccgacgacc cgcgcccggc cctgctggac
     3541 gaactcggcc tgcccgccgt ggtcatcggg gcgctcgacg gcgacgacgg cgcctatggt
     3601 gcgatctcca ccctctgggc cgacgacacc ggtgcgatgg cctccatcgt cggccacctc
     3661 cacgccctcg ggcaccgccg tatcacccat gtcgcgggcc tgcccgaact cgcccacacc
     3721 cggcgccgga tggcctgcct gcgcaccgag gccgagcgcc gcggactgcc cgacgccacc
     3781 tcggtgacca cggactactc cgacgcgcaa ggagccgagg ccacgcgccg gctgctgtcc
     3841 ggtccgcagc cgcccaccgc gatcgtctac gacaacgacg tcatggccgt cgccggcctc
     3901 gccgtcgcgg cggagcgcgg agtgtcagtc cccggcgaac tctccatcgt ggcctgggac
     3961 gactccgtcc tctgccgcag cacccacccg tcactgacgg cgctgacccg tgacaccccc
     4021 gccttcggcc gccaggcggc ccacctcctg accgcgctcc tggcaggagc cccgccgacc
     4081 cgggtccagg cgtcgacccc acgtctgacg acccgggaat cgacgagctg gacgtaggcg
     4141 gcacgctgcc gggaaacccc cgtccgcatg cacccgcacc ccgcccaaca acccccctac
     4201 ccccccgccc ttaccaaccg cttagtatgc gaaccgcacg ccaccccacc aacccggagg
     4261 cccccgtgaa ggcatggcga gtgcacacca acggcgaacc ccgagacgtc atgcgcctcg
     4321 aggacgtacc ggacccccgc cccgcccccg gcgaggccct catccgcgtt ctcgccgcga
     4381 acgtcaactt ccccgacgcg ctgctctgcc gcggccagta ccaggtccgt ccgcccatgc
     4441 ccttcacccc cggcgtggag acatgcgcgg agatcctcgc cctcggggag ggcgcggaag
     4501 gcaccgtggg agcgcgcgtc ctcgcgcaac ccgccctccc ggcaggcggt ttcgccgagc
     4561 tcgcggtcgt ggacgccaag accctgctgc ccgctcccga gtccctggac gacgccgagg
     4621 ccgccgccct gcacgtcggc taccagaccg gctggttcgg cctgcaccgc cgggcccgca
     4681 tccggcccgg cgagaccctg ctcgtccacg ccgcggcagg cggcgtcggc agcgcggccg
     4741 tacagctcgg aaaggccgcc ggggccacgg tcatcggtgt cgtcggcggc gccgacaagg
     4801 cgcgcgaagc ccacgagaac ggctgcgacg tggtgatcga ccgccgcgcc gaggatgtga
     4861 tcggcgccgt caaggacgcc accggcggcc acggcgccga cgtcgtctac gaccccgtcg
     4921 gcggcgacgc gtacacccag tccaccaagt gcgtcgcctt cgagggccgc atcgtggtcg
     4981 tcggcttcgc gagcggcagg attcccagcg cggccctcaa ccacgccctg gtgaagaact
     5041 acaccattct cggcctgcac tggggcctct acaacaccaa ggacccggcc gctgtccgcg
     5101 cctgccacga cgagctgacg aagctcgcag cgcagggcgc gatccgcccc ctcgtcagcg
     5161 agcgcctgcc gctcaccgcg gccgccgacg ccgtccagcg cgtggccgac ggcacgacca
     5221 ccggccggct cgtcgtcgtc cccgcccagg agggcccgcg atgaacgcac ctgttgcggc
     5281 cacccccggc gccggggaac tgcgcgaccg cgtcgccgcc ctcctcgccg cgcacgaccc
     5341 ggccagcacc gaccgcctcg gcttcctgcg ggcccgcttc gacgccgggc tcgcctggat
     5401 ccacttcccc gaagggctcg gcggactcgg cgcgccccgc tccctccaac cggtcgtcga
     5461 cgccgcgctc gacgccgccg gtgcccccgg caacgacccc cgccgcatcg gcatcggcct
     5521 cggcatggcc gcccccacga tcctccagta cggcacggac gagcagaagc agcgcttcct
     5581 gcgccccctg tggacgggcg aggaggtgtg gtgtcagctg ttcagcgaac ccggcgccgg
     5641 ctccgacctc gccgggctcg ccacccgggc cgtacgcgac ggcgacagct ggaccgtcga
     5701 cggccagaag gtgtggacct ccagcgcgca cctcgcccgc tgggcgatcc tcatcgcccg
     5761 caccgacccc gacgtaccca agcaccaggg catcacctac ttcgtctgcg acatgaccga
     5821 cccgggcgtc gaggtgcggc cactgcgcca gatcaccggc gaggccgagt tcaacgaggt
     5881 cttcctgacg ggcgtacgga tccccgacac gcaccgcctg ggcgcgatcg gcgacggctg
     5941 gcgggtcgcg cagaccaccc tcatgaacga gcggatggcc atcggcggca cccgcgtgcc
     6001 ccgcgagggc ggcatggtcg gcgtcgtggc ccggacctgg cgcgaacgcc ccgagctgcg
     6061 cacccacgac ctccaccagc gactgctgcg cctctgggtg gacgccgagg ccgcccggct
     6121 caccggcgaa cggctccgcc agcagctcag gcggggccgc cccggacccg agggttcggg
     6181 gatgaagctc gccttcgccc ggctcaacca ggagctcagc gccctggagg tcgagctgct
     6241 cgccgaggac ggactcacct acggcgactg gaccatggtc cggcccgaac tcgtcgactt
     6301 caccggccgc gacgccgggt accgctatct gcgcgccaag ggcaactcca tcgagggcgg
     6361 cacctcggag gtgctgctca acatcgtcgc cgagcgcgtc ctcggcctgc cgcccgagcc
     6421 ccgcaacgac aaggacctcc cgtggaagga cctgccccga tgacgccgga cctgctctac
     6481 tccgagaccg agcaggacct gcgcgccgcc gtgcgctccc tgctcgccgc ccacggagcc
     6541 cccgcgtccg tgctcgccgg tgccgagagc ggccgcccgt acgacaccgg cctctggcag
     6601 tccctggccg tgggcatggg caccgccggg ctgctcgtgc ccgagaagtc cggcggccag
     6661 ggcgcgaccg cccgcgaggc cgccgtcgtc ctggaggaac tcggccgcac cgtcgccgac
     6721 gtcccctacc tgaccagcgc ggtcctggcc gtacgcaccc tgctcggctg cgacaccggc
     6781 cgcaccgagg tcgccgcccc gctcaccgca ctcgccgagg gccggcaggt cggcgcgctc
     6841 gccgtgcccc tgccgaccgc cccgggcgcc ggtgtgcggc cgaccgtgag cgccgaaccc
     6901 accggcccgg accgggcgtt gctcaccggg acggtgaacg ccgtcgccgg tgccgccgga
     6961 gccgacgtcc tcctcgtccc cacggacacc ggcctccaca gcgtggaccc caccgcggaa
     7021 ggcgtcaccc tcaccccgct caccccgctc gacctcaccc ggccgatcgc ccggatcacc
     7081 ctctccgcag ccccggccgc actgctcgcc ggccccgacc gggcccgtac cgccctggac
     7141 gccgccctcc tcaccggcgc cggactgctc gcctcagaac agctcggcgt cgccgagtgg
     7201 tgcctgaccg aaaccgtgcg ctacgccggt gaacggcagc agttcggccg ccccatcggt
     7261 tccttccagg cactcaaaca ccggctcgcg gccctctggc tggacatcgc ctcggcccgc
     7321 gccaccgccc gcaacgccgc cgacgcgctc gcgaccgacg cccccgacgc ggcgatcgcg
     7381 gtcgccgtgg cccagtcctg ctgctccgag gtcgcggtcc gcgcggcgga ggagtgcgtc
     7441 caactccacg gcggcatcgg catgacctgg gaacaccccg cacacctcta cctcaagcgc
     7501 gccaggaccg acgccaccgc cctgggcacg ccggaccgcc accgtcaggc cctcgcccgc
     7561 ctggccgacg tgcccggccc cgtcgcctga cccggatcag gcgcggatcc ggtacaccac
     7621 attgcggcgc agcggcccct cgggtgcgct cgggtcgtcg aagtcgtccg cggggtcccg
     7681 ggtcatgccg atccgggaca tcaccgcccg ggaacgcagg ttggtgacgg tcgtcacccc
     7741 gaggatctcg ggaagcccga gggtcccgaa gccgaagtcc agggcggccc gggcggcctc
     7801 ggtggcatag ccgtgccccc aggacggacg ggcgagccgc cagccgatct ccacccccgt
     7861 gaacggcatc ccgtcatcca cctcgtcgag cccggcgaag ccgatgaact ccccggtggc
     7921 gagcacctcg acggcccacc acccgaaccc ccgctcctcg aattcggtcc ggaacctcgc
     7981 caccgacgcg tcgctctgct cacggctgag caccggcccc agatgctccc ggacctcggg
     8041 atcggcgttc atggccgccc acggcgcgag gtcggcctcc cgccagggcc ggagcgcgag
     8101 gcgggcggta cgcagttcgg tcatgcccca acccaacgcg acagccccac ccccggtcga
     8161 ccccttttcc cgggaacgcg ggggtgacgc ttgcctagcg gctgtcctcg agcggggccg
     8221 gcccgcccgc gcggccgcgg tcggtggcga acgccatgat tctggcggct ccgcgagccg
     8281 ccagaaagcg ccggcgctgc cagcgtgaac ggggctgaac gcccactcgc tccccttgcg
     8341 gtacgagcgc gagatcggtg aggcgccgcc cggcctgggc gagttcggtc aggagccgct
     8401 ccctgcgctg tccgttcgca gtggcgtgca gtgcggcgta caagccctcg atctcggcca
     8461 cggccgcccc gatgcgcagg ttgctgctgc ctgccgatga cgttctgccc tgcggcaact
     8521 gggcccctct cgtaacggat cctgtggtgc ggtctccggc gccgaggcca tcggcggctg
     8581 tgccaagccc caagggcgtt catccggccc gcgacacttg ctcatatgcg caatctagca
     8641 acctttttga ggcggtgccg ggtccgcccg caggggaggc cggggccctc cggtgagcac
     8701 cggatcggcg cgcggtggga tgcgggctgt gcgcggggcg ccgttcgggt caggggctcg
     8761 ccgggtcgaa gccgtaccgc aggggctctt ccttcacgcg caggtcgcgc cggtatacgt
     8821 acagcgccgc aatgtgcatc tcgctcgcgg ggccctccac cgcacagggg tgggtgacct
     8881 gcaccactcc cggacggttg gccagccgga tcaccacccc gtccaccggc ccgccttcca
     8941 gtacggccgt ctcccactcc gccatgccat cgtgtgtcat gaccaacact ttagatgttg
     9001 cgcaagtggg caatgccggg gagtcggcag gtgatgccgg tgcccgccga ccgcgtgtcc
     9061 acccggcccg acgtcactcg tgaaaccgcc gcaccgcggc caggcgtcga caacagtgtc
     9121 cgtactgccg tgcggatcag tcatcacaga tcaaccgctg gaaaggcaga acgacaccat
     9181 gggtatcatc ggctggatca tcctggggct gttggccgga gcgatcgcga agatcctgct
     9241 gccgggccgg gaccccggcg gcctgatcgg caccaccctc atcggcatcg ccggagcgtt
     9301 catcggcggc tggctgtccg ccaagttcct gcacaagccg atcagcaacc acttcttcga
     9361 cgccgccacc tggggctcgg cgatcgccgg ctcgctggtg ctgctgatcg gataccgcat
     9421 cttcttcggc aactcacgtg actgaagcgt caattgctct ccgctcgccg gttgatcaag
     9481 tggtatagga cattccggaa tccgtgctca attcgggaac ggtgtccttg atcgctcgga
     9541 ttgaacatgg atacagtcgc gatcaagcgc cagggggtgg cgtaacgggg atctgaatcc
     9601 tgctggtaca tccggcagtt gggtggtgtg ctcgcatccg tccggtattt cccgtgtgcg
     9661 cattcactgc tccctgagct gcaaggtcag cgagagggag gtgaattgaa tggtgaacaa
     9721 cgagcgtatg gagagccgtg agctccaggc ctacgaggcc ccggagatgt ttgagtgcgg
     9781 ctctttccag gaggagaccg gaatgctcgg caccgcgggt caggagccct tcgtgcccgc
     9841 tctccacacc cactggggct ggtaggagcg ctctgaattg caaggcccga taaaggaggt
     9901 cgaagtggtc ggtgtcggga cgccatattt cgtggttctg ccggaccatg aaaccgcgac
     9961 cgcagcggcc gaccggcttc ccccaggtgc cgcgcagatc atgacgcacc ggtccggccg
    10021 gccctgggtg gccggccggc tggccccggg gcagattctc ctggccgaac acggcgacac
    10081 ccggctcgcc gtcatcggcc agtgctcggc gagtgccgcc gaactcaccg cgacggccgc
    10141 caaggtccac gagccgcacc atctggaccg cctgggcacc gactgggccg gcagctttca
    10201 cctgatcgct ctgatcgacg gccgtgtgca catccagggc agtgcttccg ggctgcgccg
    10261 ggtcttccac ggccgcctcg gcgccctgaa cctcgccgcc gaccgggccg acacactggc
    10321 cgccctgctc gacgccccgt tcgaccggtc cgcactggcc ctgcgcctgc tcgtctccgt
    10381 acctcacccg ctgacggacc ggacgccatg gcagaacgtc acggcagtcc ccccgggctc
    10441 gcgcctgacg ctctcctccg acggtcggca gcaggccgtg accccctggt ggcgggcccc
    10501 ggagccggtg ctctccctgg aggacggagc ggcggcgctg cgccaggcgc tcgagacggc
    10561 cgtgcgggtg cgcagcgacg gcgcccggac catcaccgcc gatctctccg gcggcctgga
    10621 ctccaccagc ctcaccgtgc tggccgcccg ggagcgggcc tcgctgaccg tgttcaccat
    10681 ggagaacccg gacgaggccg acgaggacct gcgctgggca aggacggccg ccgcccacct
    10741 gccgcagctg aaccacatcg tctacccggc cgatcgactc cccggcttcc tgggaggact
    10801 cgtcggcgcg gacggtgcgc cccttcctgt ggacgtcctc cccgacgagc cctccagcgc
    10861 ggtggtcagc gccccccgga tgcgcgccgc gaaggagatg gccaccgccc acggctcacg
    10921 cctgcacctc gacgggttcg gcggcgacca gctgctgacc ggtcaccccg gctacgagca
    10981 cgatctgctg cgcagccgcc cgctgctcac cctgaagcga ctgcacaccc tccatgaact
    11041 caccggcttc cggtggagcc ccgcgctgcg cgacctgctg gacagccgct cctaccgcca
    11101 ctggctggcc accgagaccg ccgcgctgac ccggcgccgg ccgccccgcc cgcagaactc
    11161 ggccttcgcc tggggcggca ctctgcagct gccccggtgg ctcacccccg aggccggaga
    11221 cctgatcgcc cggacgctgc ggcacgccgc caggacggcg cagccgctgg ccgccgcccg
    11281 gggccgccac ggcgacctgc tggagatcca gaacaccggc cggatgatcc gccagctcca
    11341 ccaggtggtg gcgacaccgg acttcacccc ggcctccccc ttcctggacg accaggtcat
    11401 ccacgcctgc ctggccgtgc ggcccgacga gcgcgtcacc ccctgggaac tcaaaccgct
    11461 gatcaaggcg gccctggcgg acgtcctgcc gcgcgagctg ctgacccggc ggaccaaggg
    11521 cgacggggcc ctgatcgccg ccgagggctt cgagcggcac cggcgggaca tcgccgggct
    11581 ctgggactcc tccgccctgg ccgaactggg gctgatcgat cccgaaccgc tgcgcgcgct
    11641 gttccgccgc ccgtactccc cccggctcca tgagagagcc atgcccacga ccatcggctg
    11701 cgagctgtgg acccgggccg cccggcgtgc accggccgcc gcccgcacct gaacggccgc
    11761 cgcccgggcg gaagacccga ccgaaagaac atgagagcaa ggacgatgac actgagactg
    11821 cgccccgatg tctcaacggc cgacaccgaa tacggaacgg tgctgctgga cggagcgggc
    11881 ggccgctact ggcagctcaa cggctcggca tcggtcgcct tgcgggtcct gctggagggc
    11941 gggaccgcgg agcaggcggc ccagcggctg acggccacgt acgacgtcga cgagtcacgc
    12001 gcccgcgagg acgtggaacg cctgcgagtg aggctgatcg acgcgaagct ggtgcttcga
    12061 tgagcgcggt ggtgccgcac cgggtgcgcc cacggctctc tcccggacgg cgtctgctca
    12121 ccctgctcgc ggtggccgtc gccgggcggt tggcccgcag ctcgcccgcc cgcatccgga
    12181 ccgttctgac ctggctgcgc aagggtgccc gtccggctgc ctacgccgag gtgcgcgccg
    12241 cacggcaggc cgtggtcgtg gtcagcctgc gctgcgcttc cgacgagggc tgtctgcaac
    12301 gctccctggc cacggtgctg ctgtgccggg ttcgtggcag ctggccggag tgggtcgtcg
    12361 gagtgcgcgc gcgcccgccg ttcggtgccc atgcctgggt ggaagccgag ggccgcatgg
    12421 tcgaggagga agcggatcct tcctacttcc gccgcctgtt ctcggtcccg gcggcggagc
    12481 ggtaggacac ggccctgccg ccgggtgcgc ttttcccgct cagcccagtg gccgggcgta
    12541 cgtcacgaac tcccgctccg tcacgaagcc catccgttcg tagagcccca gtgccccggt
    12601 cgggttggcc gcgtcgacga ccagttccgc cttgtcgtac ccctggtgcc cggcctcggt
    12661 cagtgtgtgc gccagcaggg cgcgcgccgc gccccggccc cggtgggccg gtcgggtgcc
    12721 caggtggccg atcgtgcacg agcggtgccc cgtggccgtg ccgtcggcga cgtactcgtc
    12781 ggcgaggagg tacgccgcga cgcggccgtc ggtgtcgagc agcagggcgg agagagccgc
    12841 gcggaacgaa cggtcgccgg tgaaccaggt ctcccagtcg gctctgtccg tctcggtgtg
    12901 attccagtgg tcgcgaaaag cgtcgttgtg cgcgctgcgg gtcgcctcgt cgagggctgc
    12961 ctcgaagggc gccaggcgca ggccgtcagg caccttcacg gcgggcagcc ggtccgtgcg
    13021 caggtcgtgc gtcatgctga accagtaccg gcggggctcg aatccggcgt gcagggccag
    13081 ggccgccagc cccgcgttgg tggtcgaccc gtcgaccagc agctctcccg gcacgccggg
    13141 gtggcgctcc gcccggatcg cgtccgcgcg gtcgcgcatc cagtcgacca gccgcgcacc
    13201 gattccctgc cggcgccagt ccggatggac ggcggcggcc gttccgaagc gggcgatgtc
    13261 ccgtacctgc tccggctcgt acaccatcgc gtacgccacc agccgcgacc cccgccacag
    13321 gccggcggtg ttgtgcgcca gatccagctt ggggtcggcg agctcatgga ggacgtccgc
    13381 ctcgtcctcg tgccggcccg tcctgtcggc gcgttcgacc tcgtcgcgca aggccgcgag
    13441 gtcccgggca tcggtcgtgc tgagaggctt gaaggtgatg atcacccgac aaacagtaca
    13501 aagacccaaa aggatgtgtc gaaggaattt tcgccagacc tcgccatccg gcgcaccgcc
    13561 cggatcatga ccactccttt acgtactgtg taagcggagg gttggaacgg cacaggtggc
    13621 gagacggctc tgcggtcgtt acctgcgtca tttgccctga gaccgtccgc tgacgtccac
    13681 ctcagtccac tctctgtcgc cgctgttggc tccccgtttg gctcccggct ccggatcgcg
    13741 aagccttcgt tccgtgactg tgcgacggga gacccacctg ccgttcactt gtgccggagc
    13801 catgacgtgg ctgacgccga gcgtgtggcg cgcgtaccgt aagcgcgaag gtacggcgac
    13861 gatcgcggga ggctaggccg tgagcgacca ggcatggacc atcgaatcca tctgtgaggc
    13921 gctgggcaac cccgcgctga gtcagagatt ccttggcgag atcaaccgcg cccccgcgca
    13981 cgagctgctg accgtcttcg ccaagtggcg cacgatcgcg gccggcgtgt ccgtggccgc
    14041 tgagcgtggg cgcatgctcg ccgaagcaga ggctgtcgcg ggggagatcc ccggggactg
    14101 ggtggacatg accgatcgcg tccaggccga ggccgctgct gcacggggcc gaggcgccgc
    14161 ctgatggtct accggctcaa gtacgacttg gcggccgaag ccgtgcacga cgctctgccg
    14221 cccgaagcga gcgagcggct ttcgctcgcg cttgccgcgg catgcgatga cccgatcgca
    14281 tcgaccgaac cgtacggtga agacgacggt gtcgtacgga tgatcgtcac cgaacacgtc
    14341 atcggcgtcc tcttagccct gatccaccga cgtggtttgg ggagtgatct tgtgaccggt
    14401 ttcgagccgg tttgaggtcg gtggttgggc atgggcaggt tgtagtcgct ggtctgccca
    14461 gcttttccac gggttcggtt ccggttgggc cctggcggtg ggcgggtcgg gtaggggctg
    14521 gtcgtgtcag ccgggtgggc cgtggacggt gtcgaagagg tgtgtccagg catgctgcca
    14581 gggccagttg tgcggcaggt gcagggtgat gcgtcgtgcg gagcgggcga tccgggccgg
    14641 aacctggacc aggtgggtgc ggagagtggc ggtggtggcc ttggcgtgga aggcggaggc
    14701 cagtgcgccg gccgcccgca gcaggttgca ggtcatcgcc cacagggtca gccaggcgga
    14761 gttggcatgg aagtgtcccg agggcaggtg ggccagggcg gaggctttgc tgtcggcgat
    14821 gacctgttcg acgacggcgt ggtggcggtg ttcttgctcg gcctggaggg tccgggcggg
    14881 attgtcggtg aagaacgggt ggtagcgcca gacggggaac aactcgccct gctcgcccac
    14941 ggtggcgggt ttggcgaggt cacggacccg gcgcacgatc agccgggccg tgacccgcga
    15001 ggctttcctg cggctgacga aggcggcgta gacgggtatc tcggcgactt cggcgtccgg
    15061 gatgaggtcg ccggtctccg ggtcgggcac tgcggtcggg taggtgatct gctgccaggc
    15121 ggtgtcgggg atgctgtgga tggcccgttt gatggagggg ttcatgccgg tggtgaccga
    15181 gaagtgggcg ccggcccggc ggcaggcggc gatgacaccg gcgttgtaga actgcgagtc
    15241 cgcgcgcagg atgcgcatgc cggtgcagcc ggcctcgacg gcggtggcca gggcctcgct
    15301 gacgagtttc ggggcgccgc gggagtcggc ggctttgccg cggcgcatcc gcacggtggc
    15361 gatcaccggc cgggaggcgg gggtgcagat cgtggcgagc agggggtgca gggtgcggat
    15421 gcctttgaac cggccgtact cggcaccctg cttggcccgg ccgtagacgc gtttgtgggt
    15481 ggaatcgaca tcgatgaatg ccttctcgtc ggagccgggc agcagcgggg tgtgcgcggc
    15541 cagttccgcg aggaacctgc ggtggacagc gtggagttgg agggcatggc catgggtgaa
    15601 ggagcggagg aaggtgccca gggtggacgg ggcacggatc cctcggaaca cggtcggcat
    15661 cgcgccgtgg cgcagcgcgc ccaggtcgtc gatgctgtcg gcccctgcgg ccatgccggc
    15721 cacgatgctg gtgaccttgg cgtccgccgc cgcacccgcg ccgttcttcg ccccggtcag
    15781 cctcaccttc tccgtcacca gccggggcag accgcaccgc ccggccagtc gcatcaccgg
    15841 gaccagcccg gcatgcgcga tcagattcgg gtcatcgaac acggcggaga ccgccgctgg
    15901 cgtgtgggaa acttgcatct cggaagtgcc ttgctgatta tgcgtgctgg aagcctgaag
    15961 aactcccatc attgcaggtc acaaggcact ttcttgtttt ccaagacgtt atccacaagg
    16021 cgtccggcgg tggatcaagg cttagtcggc cagatcacga agacactcac tgtcctccag
    16081 ctgagctaca ccggctgaac tggacttggg caacaggcgg gctgcgcccg atcctggccc
    16141 tgggatctta ttatctcgat ccactggcct tgcgcttgat ccatcgtgcg acgtcgggcg
    16201 gttgacctgc ggtttcgcgt gtcatgagcg tcgtccgacg acaacttcgt cgcgcatgcg
    16261 tcgggaacga ggaagcaggg gtggccatga ggccacttcc tgtgcgactt ccgtagcttc
    16321 ttcttggctt ccttcgccct cccctccttc tggtcggcca ctccgggcgg gctcgttata
    16381 ccgagccgaa atgcgcccgc gaggcatgcg tcccgctgga tcccaccacg cgtgtaaggc
    16441 gttcggaacg gtaatgcagt tcctaaaggg cccaagttgc catcttgtcg gcccggggtg
    16501 ttactggacg gagaggctag aaggagtatg ggggtttcgc cgatatggtt gtagaaaatc
    16561 tccagttggc tgaagctgtt acatcgtgta ggcaattctg gattagcatt gccggtatag
    16621 tgtttcccgc agccatcgcc atctgggtgg cgactgcgtc tcttcgtgga aacagggcta
    16681 ttcagagaga aatgagagcc gaaggggagt atgctgcagt gaggcagcaa gatcgacagg
    16741 attgtaagga ggcgctgcgt gaattctttg atatcgccgc aaagcactgg aatattacat
    16801 gccgaatggc cgaggtgaaa agtaaagcgc gaaggctcgc gctacagtca gagatggaag
    16861 aagtcgacga gcggttgtcg gctattcgtt cgggaataga tattctgagc ggagcgagtg
    16921 tgatggatgc catcgcgcgt tacgtagatg ccttgcgtgt tgaaagggat aatgcttgga
    16981 atggccgaaa agtagaaaag agcgtgtgcg atgaaccata tgtggcggcc gtggagtgta
    17041 cgcgctcact cctcaggttc gccgacgtgg cgccaaatgg cgtaaagcgg atgtagcaac
    17101 aacctgatct ctcctctgga gtggggcgac tggcgtcatc ctcagtcttc tgggatcttg
    17161 tgaagccatc ccagcgcctc tgaaatctcc agagacagat ccttggtgtc cgcccagcgg
    17221 tcaatgacaa cagctgctgc ttccgtcggc tccgccggca gacacctctc tgatagcgcg
    17281 ctcaccgtct cccgcatctc cggcgcccag cgccatgact gcgaagccac cttggggatg
    17341 tactcaatct ccgcgaggta ggtggttgta cgaccctcgc cacatcgagc agctcgttct
    17401 cgacaccgta atcccgggca agcgtgtacg agacagcggc gagtacgcgg ctcgccttcc
    17461 ggaatgtgct gtacggcaca gcaagggcaa ggtcgccgac cgtccgttgg tgcggtccgt
    17521 gggccgcgag gtttcagccc tccagcgcca ctacgcggtc ccgcagttcg tcaacttcgc
    17581 gacgcagctt gtcgacttcc tgccgcagct cttcgacagt tgtctggggg gcgttcgctc
    17641 tggcgaggct cgccgagtct ggcgtcagga aggcgcctga gtaatgcccg accgttgagg
    17701 cgctgacctg ctcttatgtc ggtatgactc cctcgcgaag aggaacttcg gcgggtattc
    17761 gacaggggtg gagtgctaaa cgatggatgg tcccgcagca ccgcatcacg tgatgcggtg
    17821 atctcgtggt cgtcgtgcac gcaggggtgg tcccgtgcgt tcgccgatca cacccgacgg
    17881 gtttctcgtg ttcccctgcg ctgggtgttc gtcgtctgga ctgggcatgc gacgctgtga
    17941 gtctgtcgac ggacgtacag agggggagcg cgtgtcgcag cagatcagcc ctcgggggac
    18001 cttcctgaag gtcgctgatg cggtgagagc gcagatcgaa tcggatctgg agatggcgga
    18061 gcttccgtcc gccgccgaag tcgtgcgcgc ccacggggtc tcgcgcggtg tcgggctccg
    18121 ggccttcggc gtcttgcggg aggaggggct agcaaaaccg gctcctggtg gctgatggcg
    18181 agtggtcagg gccggacagc agacagaccg ccggccgttg gagaagcgga tcgcgggcgt
    18241 catcgcggat gaagagcttc aggtcggggc ggtgttcccc agcgcgtctg cgctgtgcgc
    18301 gcggttcggc gtctagcggc cgaccgtgac caaggcctcg gacaagctgc aagccgaggg
    18361 gcttctgccc ggaagagcgt caggggaagt cgcggaccgt ccgcgctctc ccagaccggg
    18421 atgggggctc tagccttgag cgccatggga ttggctgagt gggcctaccc ccttgctgaa
    18481 tcgctgcttg ccaaaacgct gttgcgccga taagcactcg ttgggagttg gccgagcgcg
    18541 cgcgaacgat cgctccgctc ctcggtgagg acgccgagct gctggaggcg gccgcggtac
    18601 tccatgacgt cggctatgcg cccgacctcg cccaaaccgg ctttcactcg ctggacggag
    18661 ctcggtatct acggggtgta gcgcacgcgg acgagcggtc gtgcgcctgc tggtgcacca
    18721 cttgtgtgcg tggatgaagg cggaagcgcg agggctgcgc gacgagttgg agagcgagtt
    18781 tccacgcggg cgtccgcacc tcatcgacgc gctctgctac tgcgacatga acaccacccc
    18841 ggacggcact gctacgaacc ccgttgaccg ggtgaacgag attgccgggc gctatggccc
    18901 cggcagcctc atagacaagt tcatccgccg ccgctgagcc ggagatcctg tcgagcacag
    18961 cgcgtgtgct cgggcagctc gccagcgtcg agcatcagcc gatatagggc gctgtccgcg
    19021 tccggtccat ggcgtgctcg atcctgagtc gcatggtcgg gtggatgtcg tacgccgaca
    19081 ggtccgccgg attgacccag cggacctgtg tcgtctcgtc gctcgtacga acttccccgc
    19141 cgatcggccg ggcccgaaag cagatgctga attgctgccg gacctctccg tcgtcgtagg
    19201 ccaagacatg tcccggatcg gtgtagatcc cggacatgtc gatgacctcg accttgatgc
    19261 cggtttcttc tcggacctcg cgcacacggt gtcgctgacg aattcgcctg catcgtgccc
    19321 accgccggga agtgcccaac ggccgttgtc tgatcgctgg atcatcagca cctggccctc
    19381 gtcgttctgc acgaatgcga cgacggacgg cacgaccgag ttggccggcg gggcgtcggg
    19441 gtcgtgaagg taatcaatgc gtcccatgct caagctcctg tgaagtcgtg gtctgtcaac
    19501 cggcgtgctc ctccccagat ctgttcgagg ctattcacgt acgtgtcgaa cagtcctcct
    19561 ccgggcaggc ggcgcaggcc ccgattcgag gtcatcgctc gcgtcgtcgg gtacagcggt
    19621 accgccacca cagagagggt ctaccgcaag cagctgcgcc cggtgatcac ggaaggggcg
    19681 gaagcaatgg acgagatctt cggagggggc tgaagttgcc gagggagccc ccgcggccgg
    19741 tggtccgcca gcgcggtggc tcccctttgg ttcccccttt ggctccctgg gcccgccccg
    19801 gatcatgacc actcctttac gtactgttta attgcgactg gttcgcaata gcagcaaaac
    19861 gtgagtaaga ggtgtggggc atgacggccc ggtccgtacg gggagtggcc gccgcggcca
    19921 tggcaggggt tctggcggca ggtgccgcgg cgtgttcgac gcccgggggc gggggcgagg
    19981 acaaggagtc gctggtcgtc gggctcgcca atgagcccga gacgctcagt ccgctgctcg
    20041 gctacggcaa ggacggcaac tccaagatct tcgacgggct gctccgccgc gacgcggaca
    20101 tgaagctccg gcccgcgctc gccgccgcgc tgcccgccgt ggccgacgac gggaagacgt
    20161 atacctacaa gctccggcac ggggtgaagt tcagcgacgg gaagcccttc tccgccaagg
    20221 acgtggtctt cacctaccgg accatcctcg acgagaagac caacaacgcc gccaagggcg
    20281 agctcgacgc catcgacgcg gtgaccgccg agggcgacga cacggtggtc ttcacgctca
    20341 agtaccccta cgcgccgttc gccgagcgca ccgtgttgcc catcgccccc gagcacgcgg
    20401 cgaaggggca ggacgtcaac accgggtcgt tcaacaccgc gccgatcggc acgggtccgt
    20461 acgtcctgac cggctggagc aagggcgaga agctgagctt caaggccaac cccggctact
    20521 ggggcggcga gccgaagatc aagaagctca ccatggcgat catcaaggac gacgacgtcc
    20581 gcgccacccg gctgcgctcc ggcgacctcg acggcgcgat cctgccgccc aacctcgcca
    20641 aggggttcaa gggcgacaag tccaagctgt cggtcaccgc ccggaccacc gacttccgcg
    20701 gcgtcaccct gccgacggcg aacaaggtga ccggcgacat cgccgtccgc cgcgccctcg
    20761 acctcgccgt cgaccgcaag gccatggtcg acaagctcct cgaaggcgcg ggcaaggcgg
    20821 gctacggccc ggtgcccacc gacagcgagt ggttcgccaa gggcaccgag cgcccgtacg
    20881 acctcgacaa ggcgaagaag ctgctcgacg acgcgggctg gaagaccggc gacggcggca
    20941 tccgggagaa ggacgggcag cgcgcggagt tcaccctctg gttccccgcc ggtgacaagc
    21001 tccgccagga gcacgccctc gccttcgcct ccgacgccaa gaaggccggc ctcaaggtcg
    21061 aggtgcagag cggcacctgg gaggtcatcg aaccgcggat gaagaacgac gcggtcctgg
    21121 ccggcggcgg caaccccgcc gacccggact tcgacctcta caacctgctc cactcctcgc
    21181 tcgccctcga cggcttcaac aacatggccg cctacgtgga ccccgaggtc gacaaggccc
    21241 tggaggaagg ccgccgcagc ggtgacagga ccgcacgcaa ggccgcctac gacaaggtcc
    21301 agcgcgggct cgccgacaac cccggctaca ccttcctcac ccacgtcgac cacctctacg
    21361 tcatgaacga cgagtggcag gacatcacca cccaggtcga gccgcacgac cacggcctgg
    21421 gcgccggacc gtggtggaac gtcgagtcct ggcagccgaa gaagtgaccc gaggctccgc
    21481 ccggctcccc tgggggccga tggcgcgcat ggccggacgg cggctgcttg ccgccgtccc
    21541 cgtgctcgcc gccgtcacct tcggcgtctt cgccatcgcc gcggcctcgc cgttcgaccc
    21601 ggcccaggcg tacgccggct ccgccggact gagcgcgggc cagggcgtcc tcgatcagct
    21661 gcgcgagaac ctcggcgccg accggccgtt cgccgtccgc tggtgggact ggatcaccgc
    21721 cgccctcacc ggcgacctgg gcgactccag ctcgctgcgc cagcccgtcg cccaggtcat
    21781 cggcgaacgc gtcggctggt ccgtgctcct gtgcgccgtc gccttcgcgc tggcgctcgc
    21841 ggtgggcacg gcgctgggcg tcctcgcggc gcggcgccgg ggcggcctgt tcgaccgggc
    21901 cgtgacctcc gtggcgtacg cgctcgaagc ggcgccgccc ttctggctcg ggctgctcgc
    21961 catctggctc ttcgccctca agctcgacgc cctgcccgcc ggaggcctga ccgacacggg
    22021 cagcgacgcg gccacacccg gccagatcgc ctcccacgtc gtcctgcccg ccgtggtgct
    22081 cgccgtctcc cagctgccgt ggttcgtgct gtacgtacgc cagggcgtcg gcgacgcact
    22141 ggaggaggac cccgtacgcg gagcacgcgc acgtggcctg cgcgaacgga ccgtcctcct
    22201 ccaccacgcc ctgcgctccg ggctgttgcc ggttctcacg ctcatcggct cgcgcgtccc
    22261 cgaactcatc accggcgcgc tcctggtgga gaccgtcttc agctggcccg gcatcgcctc
    22321 cgcgaccgtg gaggcggcca ccaaggtcga cttccctctg ctcgcggccc tgaccgtgct
    22381 cgccacggcc gcggtcctgg tgggcaatct gctgtccgac ctgctgtacg gactggccga
    22441 cccgagagtg ggattcgatg gctgagaccg tcagcggtac ggccc
//
