LOCUS       NZ_CP031455            22073 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces olivoreticuli subsp. olivoreticuli strain ATCC 31159
            chromosome, complete genome.
ACCESSION   NZ_CP031455
VERSION     NZ_CP031455.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivoreticuli subsp. olivoreticuli
  ORGANISM  Streptomyces olivoreticuli subsp. olivoreticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Complete genome sequence of Streptomyces olivoreticuli ATCC 31159,
            producer of anticancer bestatin and diverse secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2018) Tianjin Key Laboratory of Food
            Biotechnology, College of Biotechnology and Food Science, Tianjin
            University of Commerce, NO.409 Guangrong Road, Tianjin, Tianjin
            300134, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-JUN-2018
            Assembly Method                   :: SMRT Link v. 5.1.0
            Assembly Name                     :: TJCU_BT_311
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: SMRT Link v5.1.0
            Genome Coverage                   :: 145.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003391135.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 04:49:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,562
            CDSs (total)                      :: 7,459
            Genes (coding)                    :: 7,276
            CDSs (with protein)               :: 7,276
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 183
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 183
            Pseudo Genes (frameshifted)       :: 61 of 183
            Pseudo Genes (incomplete)         :: 150 of 183
            Pseudo Genes (internal stop)      :: 18 of 183
            Pseudo Genes (multiple problems)  :: 41 of 183
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:12:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7462401
            Orig. end                         :: 7484474
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Hongyu Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22073
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="36"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22073
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22073
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12073](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12073)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            40..402
                     /gene="uraH"
                     /locus_tag="DXZ73_RS32375"
     CDS             40..402
                     /EC_number="3.5.2.17"
                     /GO_process="GO:0019628 - urate catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="uraH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656872.1"
                     /locus_tag="DXZ73_RS32375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxyisourate hydrolase"
                     /protein_id="WP_116214515.1"
                     /transl_table=11
                     /translation="MSGGTTTVTVSTHILDTTAGRPARGVAVELSARAKSDAPWEPAGT
                     STTDADGRCKDFPALPAGTTQARLLFAVEPYLSRERAEGAAFFPEVAIAFAVAPGEHYH
                     VPLLLNPFGYSVYRGS"
     gene            411..1307
                     /gene="pucL"
                     /locus_tag="DXZ73_RS32380"
     CDS             411..1307
                     /EC_number="1.7.3.3"
                     /GO_function="GO:0004846 - urate oxidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0019628 - urate catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pucL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119024.1"
                     /locus_tag="DXZ73_RS32380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="factor-independent urate hydroxylase"
                     /protein_id="WP_116214516.1"
                     /transl_table=11
                     /translation="MPILGQNQYGKAECRVLKVTRDGSTHHLKDLNVSVALSGDMEEVH
                     LSGSNSRVLTTDATKNTVFAFAKERGIASAEAFGVHLARHFVVSQQSVRTARIRLEEYT
                     WERMETPGEGRHSFVRTNQETRTAQVTFDGHAWQVISGLKDLVVLNTTDSEFHGYVKDR
                     YTTLRETHDRILATQVHARWRHARFDDTVRSPDWNGSYRAARGHLLTAFADTYSYSLQQ
                     TLFQMGSRVIDHRPEIDEIRLSLPNKHHFLADLEPFGLTNDNEVYFAADRPYGLIEATV
                     LREGAEPAVPVDLTNLP"
     gene            1328..2725
                     /locus_tag="DXZ73_RS32385"
     CDS             1328..2725
                     /EC_number="3.5.4.32"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153179.1"
                     /locus_tag="DXZ73_RS32385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="8-oxoguanine deaminase"
                     /protein_id="WP_116214517.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 3.3e-60, bitscore:
                     202.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPPPAPRTPDRIVIENCAVATVDAQDTEHPSGHVVVAGNRIES
                     VGAGPAPEGLTGVVRRVDGTGHLLTPGLVNTHHHFYQWLTRGLAQNSPLFDWLVALYPI
                     WARIDEEMVYAAARGSLAMMARGGVTTAMDHHYVFPRGSGDLLGAEIRAAREMGVRFSP
                     TRGSMDRGQSDGGLPPDFAVETTEAALIATEEAIDTHHDPSFDSMLRIGVAPCSPFSVS
                     TELLREAAVLARRKGVRLHTHGSETVEEEQFCKELFGMGPTDYFESTGWLGDDVWMAHC
                     IHMDDTDIAAFARTGTGVGHCPSSNARIAAGTARVPDLLRAGVPVGLGVDGTASNESGE
                     LHTELRNALLIHRLAGGAAALNVRQVLRLGTYGGAQVLGRAAEIGSLEPGKLADLVLWK
                     LDGLGHSTIADPVAALVLGAAAPVTLCLVDGRAVVEDGRLVTVDEDAVARDARAASRRL
                     ARIAAGD"
     gene            2967..4382
                     /locus_tag="DXZ73_RS32390"
     CDS             2967..4382
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092790.1"
                     /locus_tag="DXZ73_RS32390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleobase:cation symporter-2 family protein"
                     /protein_id="WP_116214518.1"
                     /transl_table=11
                     /translation="MATAPRFTERSTAPDGDDIHPVDRLLPPGKLIAGGFQHVAASYAG
                     VVAPPLVLGAYIGLSPLEITFLVGAALFTAGIATLLQTIGFWKVGARLPFVNGVSFAGV
                     APMLAVADAQPHKRDALPVIYGAVIVAGVLGFVLAPYFCKLIRFFPPVVSGTVITLIGI
                     TLLPVAFGWIQGGHPERPASLTDLGLAGATLAVVLGLRRLLKGFLQQIAILLGLVVGTL
                     IAIPVGAVDFSPAEHARLVGFPSPFHFGAPHFAISAIVSMCVLMLVCMTESTADMLALG
                     EVVGRAADEKVIARGLRADTLGTAVSPLFNGFANSAFAQNIGLVAITRVRSRFVVATCG
                     LMFVLLGLSPVFASLIAVVPRPVLGGAGIVLFGSVAASGVNVLLKAGLDRGDNLLVAAT
                     SLGLGLIPVVSRTFYDNTAIPSTLKIILDSGVSAGCVTAVALNLLFGGTGEKNPPDTPA
                     VSHPLTPPSEQNR"
     gene            4410..5936
                     /locus_tag="DXZ73_RS32395"
     CDS             4410..5936
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016579002.1"
                     /locus_tag="DXZ73_RS32395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YfcC family protein"
                     /protein_id="WP_116214519.1"
                     /transl_table=11
                     /translation="MDQPPQGPAPTAESPGRGKFTFPSALTVLAIVTLAVWALTFVIPS
                     GTYRRNDTGKPLQGTYHREAAPGNFVHRLGDLFLSPVNGLYGIRDSKTGQVAPDAVGAL
                     YGSAGVFLFVLAIGAFITVVFATGALDRGIERLAHRLRERGALLIAGVMAVFSLLGTVE
                     GFAEETLGFYGLIVPLMLALGYDRMVATGTIILGAGVGVLASTVNPFATGVASSAAEIS
                     LGDGIALRFTMWIVLTAVTIGYVIRYAHKVRADPGRSLVGFLPGDRELAAAAEEPPELT
                     SLQKAVLGAVALVFAFMIFSVIPWSSALTGKADATPYGWELGWSFAQLAALFLVAAVIV
                     GVVARLGEQQLSARIVQGAGDFIAPALTIVLARGVTVIMNNARITDTVLHSIEGAVSGT
                     PAALFGVMVYIVNLPLAFLIPSTSGHATLAMPILAPLADFAGVARSVVVTAWEAASGVM
                     NLWVPTTAVIMGGVALAKVGYDKYLRFVWPLLLLLSVLVCGFVALGAVAG"
     gene            6197..7417
                     /locus_tag="DXZ73_RS32400"
     CDS             6197..7417
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1237: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082610.1"
                     /locus_tag="DXZ73_RS32400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IS110 family transposase"
                     /protein_id="WP_116211963.1"
                     /transl_table=11
                     /translation="MFIGWDWATETHDVTVMDNSGARVARWELAHTEEGIARTLAKLAK
                     HGSPADLPVAIETTRGLVVDRLLAAGHPVVPVHPNAFHAMRPRWGASKAKTDAGDSLKL
                     ADYLRTDGHFLPRLEPTEQVTMELQALTRQRADHVAARIAAINQLAALLDTHWPGGKAV
                     FSSLDSDIALAFLERYPTPAAAAKLTAGRLEAWCKRRGYSGKKPGSVLIERLRSSPKPA
                     SRLSDSVIAQLVRVQVQLVKGIRATIRSLDEAIADAVAAHPYAQLFATMPRIGTVNLGQ
                     IVGEIGPILERSKTSEQFIAETGVVPVTRASGKSRVVTFRYAANRRARLAVVGYADNSR
                     HASDWAAKIYNDARANKKRHPHAARILARAWLRVMWACWRTGTCYDPDTHRANNKINQD
                     PEAALAA"
     gene            complement(7435..8328)
                     /gene="pqqB"
                     /locus_tag="DXZ73_RS32405"
     CDS             complement(7435..8328)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="DXZ73_RS32405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_116214520.1"
                     /transl_table=11
                     /translation="MRLRVLGTAAGGGLPQWNCACPGCSRARAAGPAVWRSQECLAVSA
                     SPDAWYLVNASPDVRTQILATPGLAPPGGTRHSPLRGVLLTDGELDHTAGLLALREGAA
                     LDLFAPAAVTTALTEDFPLRSLLAPYGAARWRPIAGELRLDDGRLRVTAIPVSDKRPRY
                     AAGSTRPGPWVVAYRFDDAVTGAAAVYAPSLARWPEELDAALAGVGCAILDGTFWSEDE
                     MERATGHGPGARAMGHLPIGGTGGTLARLRGRTGVRCLYTHLNNTNPAADPASRERSVL
                     SAALVEVASDGQEIRL"
     gene            complement(8347..9924)
                     /locus_tag="DXZ73_RS32410"
     CDS             complement(8347..9924)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS32410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116214521.1"
                     /transl_table=11
                     /translation="MNPLPPAGLSVTTQHNDNRRTGANLLETTLHPGNVRPDTFGKLFS
                     RPVDGQIYAQPLYLAQCPVEGHGLRNVVFTATMHNSVYAFDADDPTASAPLWHASLGPS
                     VTLPDANVGPPVYHDIAVEVGVVSTPVIDVERHVLHVVAFTKEQGAYHHTLHALDLSTG
                     REALGGPVRITATVPGTGDGSAQGKLTFTSNRQIQRAALTLAGGRVYVAFAAYGDQDPY
                     HGWVFGFDAGDLRCAGVYVTTPGTQRGGIWQAGQGLGVDDHGNLYFMTGNGGFRPDGSE
                     LGDAVVKLAPGLTLADWFSPFNNAALDAADADLGSAGPLLIPDTRLLLGGGKEGKFYLL
                     DTGNMGHFHAGSDSQIVQSFFVVTPDRNSHHIHGGAVHWNFRGGGGPWVYVWPENAFLR
                     AYRFTGGTFQTAPVSTSTTTDPRGVPGGSPGMPGGFLSVSAHGDDPATGLVWATHPYRD
                     NANQAVVEGVFRAYQATDLTREVWNSKMNATRDDVGMFAKFAPPTVAAGKVYVPTFSGA
                     LHAYGLLG"
     gene            complement(10001..11065)
                     /gene="pqqE"
                     /locus_tag="DXZ73_RS32415"
     CDS             complement(10001..11065)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671044.1"
                     /locus_tag="DXZ73_RS32415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_116214522.1"
                     /sec_met_domain="PF04055 (E-value: 2.7e-18, bitscore: 65.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1e-09, bitscore: 37.4,
                     seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2e-09, bitscore: 36.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRPLGLLAELTYRCPLRCAYCSNPVELDAYAEELTLSQWRRVLA
                     EARELGVLQVHLSGGEPLVRRDLAGIVAHAHGLGLYTGLITGGQALTAARLSALTAAGL
                     DHVQISVQSSDAPEADALAGRPAHRRKLAAATLVKDAGLPLTLNAVLHRANIGQAGALV
                     ELAVRLRADRLELANAQYYGWALLNRRALLPTREQLTAAESVIRAARERHAGRLEIVYV
                     VSDLHDGVPKPCMHGWGSRQLTVAPNGDVLPCAAAGRIPGLVVPTVRRAGLADIWFRSE
                     AFNLFRGTDWMREPCRSCPRKEIDHGGCRCQAFQLTGDAAATDPACALSPHHALVQGIV
                     RDAEAIPGAALPRG"
     gene            complement(11058..11384)
                     /gene="pqqD"
                     /locus_tag="DXZ73_RS32420"
     CDS             complement(11058..11384)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03859.1"
                     /locus_tag="DXZ73_RS32420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_116214523.1"
                     /sec_met_domain="PqqD_RRE (E-value: 5.1e-15, bitscore:
                     53.8, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.2e-11, bitscore: 41.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPGGAGPAGPTADAGVRWRLRGGVRLGHDTVRDTGVLLHPEGVL
                     LLNETGAAVLALCDGATDEHALTGALARTYASVPAGEVRAFLAELARRRLIEPSPGPPE
                     HTGG"
     aSDomain        complement(11094..11333)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DXZ73_RS32420_PqqD_RRE.1"
                     /evalue="1.90E-17"
                     /identifier="RREFam006.1"
                     /label="DXZ73_RS32420"
                     /locus_tag="DXZ73_RS32420"
                     /protein_end="97"
                     /protein_start="17"
                     /score="53.8"
                     /tool="antismash"
                     /translation="RWRLRGGVRLGHDTVRDTGVLLHPEGVLLLNETGAAVLALCDGAT
                     DEHALTGALARTYASVPAGEVRAFLAELARRRLIE"
     gene            complement(11381..12073)
                     /gene="pqqC"
                     /locus_tag="DXZ73_RS32425"
     CDS             complement(11381..12073)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019524875.1"
                     /locus_tag="DXZ73_RS32425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_116216017.1"
                     /sec_met_domain="TIGR02111 (E-value: 8.9e-87, bitscore:
                     289.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAWSTEEFTTALRAHSDRYWHKHPLHLRLHRGELSRQELRQWI
                     ANRWYYQKCLPQKDAAVLANCPDAEVRRRWVQRVLYQDGTDDRHGGHAQWLDLAEAAGL
                     SRSEVLDERHVLPGVRFATDAYVTFARTRPWTEAVASSLTELFSPDLMRERLAALRTHY
                     PWVSASGHAYFAERPAAATCDARHALELVLAHCTTRERQQAALAALAFKCDVLWSILDA
                     LEHAGRAR"
     gene            complement(12073..12300)
                     /locus_tag="DXZ73_RS32430"
     CDS             complement(12073..12300)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS32430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116214524.1"
                     /transl_table=11
                     /translation="MAEAATTSSPRPVARSSGPGPGPGSTTAVPRTGTARQGRPAHRES
                     PGGPALRPWLPPAFADIELGQEVTAYAGRW"
     gene            complement(12470..14095)
                     /gene="aceB"
                     /locus_tag="DXZ73_RS32435"
     CDS             complement(12470..14095)
                     /EC_number="2.3.3.9"
                     /GO_function="GO:0004474 - malate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aceB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005309801.1"
                     /locus_tag="DXZ73_RS32435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="malate synthase A"
                     /protein_id="WP_116214525.1"
                     /transl_table=11
                     /translation="MSAPAPSSPVIVDAPPVEQQAEVLTEEALAFVGALHHRFTPRRDE
                     LLARRAARRAEIARSAALDFLPETAGIREDDSWRVAPAPAALQDRRVEITGPTDRKMAV
                     NALNSGARIWLADFEDASAPTWENVVRGQLNLTDAFERRIDFTDDRGKAYALRPAEELA
                     TVVVRPRGWHLDERHLTVDGRPVPGALVDFGLYFFHNARRLIDLGKGPYFYLPKTESHL
                     EARLWNDVFVFAQDHVGIPRGTVRATVLIETITAAYEMEEILFELREHASGLNAGRWDY
                     LFSIVKNFRDAGPRFVLPDRNAVTMTAPFMRAYTELLVRTCHRRGAHAVGGMAAFIPSR
                     KDPEVNEAAFEKVRADKDREARDGFDGSWVAHPDLVPVARASFDAVLGDRPHQKDRLRE
                     DVRVTAAELIAVDSLEEKPTYEGLRNAVAVGIRYIEAWLRGSGAVAIFHLMEDAATAEI
                     SRSQIWQWINAGVVFGNGEKATAELARRVAAEELAAIRAEAGEEAFAAGRWQQAHDLLL
                     KVALDEDYTEFLTLPAYELLDRPA"
     misc_feature    complement(14136..14151)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    14150..14165
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.43"
                     /tool="antismash"
     gene            complement(14260..14883)
                     /locus_tag="DXZ73_RS32440"
     CDS             complement(14260..14883)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055643.1"
                     /locus_tag="DXZ73_RS32440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_116214526.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.3e-34, bitscore:
                     117.3, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTTDTTDTPGAVPVAGLLLAAGGGRRLGGRPKALLGHGGRPLV
                     EFAARVLRDGGCVPRYVVLGAAAADVRGRAELPDCVLVDNPDWADGMGSSLRAGLAALA
                     STDVSAVLVTLVDQPRVGAEAVARLVAAHRAGAGLAAAAYGGERGHPVLFAREHWAGVA
                     RSAVGDRGARAYLREHAAEVTLVECADIAAPDDVDTPDDLRLLD"
     gene            15058..15459
                     /locus_tag="DXZ73_RS32445"
     CDS             15058..15459
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554613.1"
                     /locus_tag="DXZ73_RS32445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5955 family protein"
                     /protein_id="WP_240351592.1"
                     /transl_table=11
                     /translation="MEEERVDRVGQDPRVDALRDAVSRLRRALAAHPARLPDRDAAEDE
                     LAALDAMAREGEPEVPRLRRSLLLVAGAVGSVSALAAALAELRAAVDRFGGTRVPEQGS
                     GRPLDEAARGAPEEGAHRVPSPREAPGED"
     misc_feature    15163..15165
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15478..16257)
                     /locus_tag="DXZ73_RS32450"
     CDS             complement(15478..16257)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175536.1"
                     /locus_tag="DXZ73_RS32450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_116214527.1"
                     /transl_table=11
                     /translation="MPSPADPRTVPTSGGVQSLERAFDLLERMADAGGEVGLSELSTTS
                     GLPLPTIHRLMRTLVACGYVRQQPNRRYSLGPRLIRLGESASRLLGTWARPHLARLVEE
                     TGETANMALLDGDEVVYVAQVPSRHSVRMFTEVGRRVLPHTTGVGKALLAQSPDDEVRA
                     LLARTGMPAATEKTITTPDVFLEALARVRESGYAVDDNEQEIGVRCLAVPVPDSPTSAA
                     ISISGPAGRVTDAATEKIVPLLQEVAAELSLALAATA"
     misc_feature    16325..16339
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.18"
                     /tool="antismash"
     gene            16489..17892
                     /gene="allB"
                     /locus_tag="DXZ73_RS32455"
     CDS             16489..17892
                     /EC_number="3.5.2.5"
                     /GO_function="GO:0004038 - allantoinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0050897 - cobalt ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="allB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612372.1"
                     /locus_tag="DXZ73_RS32455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="allantoinase AllB"
                     /protein_id="WP_240351593.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 9.1e-19, bitscore:
                     66.6, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAATDTRVPVPPVELVLRSTRVVTPEGVRPASVTVAGGRIAAVLP
                     YATGPGPGPGAVGGPYGTGAVVEDLGDDVLLPGLVDTHVHINDPGRTEWEGFATATRAA
                     AAGGITTLVDMPLNSLPPTTTLEHLRTKQGVACDKAHVDLGFWGGALPGNLAELRPLHD
                     AGVFGFKAFLSPSGVEEFPSLGPGDLEAVAARIAALDGLLIVHAEDPGHLRRAPRPDGP
                     RYSGFLASRPRAAENEAIARLISVARRLGTRVHILHLSSSDALPMIAAAKADGVRLTVE
                     TCPHFLTLTAEEVPDGATEFKCCPPIREAANRDALWAGLADGTIDCVVSDHSPCTTDLK
                     VPDFGRAWGGISSLQLGLPAVWTEARRRGHTLHDLARWMSGGPAALAGLSAKGAVEAGR
                     DADFAVLAPDETFTVDPAALHHRNHVTAYAGKTLHGVVRAAWLRGRRITGHGGPTEPTG
                     LLLERQRSA"
     gene            17889..18974
                     /gene="alc"
                     /locus_tag="DXZ73_RS32460"
     CDS             17889..18974
                     /EC_number="3.5.3.4"
                     /GO_function="GO:0004037 - allantoicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0000256 - allantoin catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="alc"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642452.1"
                     /locus_tag="DXZ73_RS32460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="allantoicase"
                     /protein_id="WP_116214528.1"
                     /transl_table=11
                     /translation="MNGTPADIPSFTGDANPYAGGDPYADYRTAAFPFDRFPDLADRRL
                     GAGVIAANDEFFAERENLLKPGAAHFDPEHFGHKGKIMDGWETRRRRGASAATPHPADD
                     DLDWALVRLGAPGVIHGIVVDTAHFRGNHPQAVGVEATALPGTPSPEELLADGVKWTVL
                     VPRTSVGGHAANGFAVDCPERFTHLRLSQYPDGGIARLRVHGESVPDLAWLAALGTFDL
                     AALENGGHVEDASDRFYSSPFHTIHPGRSRRMDDGWETRRRRDNGHDWVRYRLTGRAEL
                     RAIEIDTGCYKGNSAGWATVSVLDAANSSGWTEVVPRTRLQPDAVHRFVLPGPVVATHV
                     RLDIHPDGGVARLRVHGSLVS"
     gene            complement(19236..20438)
                     /locus_tag="DXZ73_RS32465"
     CDS             complement(19236..20438)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612382.1"
                     /locus_tag="DXZ73_RS32465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_116214529.1"
                     /sec_met_domain="p450 (E-value: 2.9e-24, bitscore: 84.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDTGELVDLAAMGQEFARDPYRVYAELRAIGPVHRVRMPEGAE
                     AWLVVGYDEVRATLNDPRLSKDWLTAADDVGLIPVASGPHMLIQDAPHHTRLRKLVTKE
                     FTPRRVEAMAPQVQRMTDELLDAMAAAPDRRTDLVDALSFPLPMGVICELLGVPSLDRE
                     AFRAWSDIAVGSAPLEEKAVASSAGRAYLTELVAAKREEPGDDLLSALIRTTDEDGDRL
                     SPDELLGMAWLLLVAGHETTVNLISNGVLALLQHPDQLAELRADPGLLENAVEEMLRYD
                     GPVETPTYRFTTEPVEIGGVSIPGGGALVLPVLADADRDPARFPEPHRFDIRRDARGHV
                     AFGHGIHYCLGAPLARLEARIAIRSLLERFPELALDVHPGALAWREGLLIRGPRWVPVR
                     F"
     misc_feature    20454..20467
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    20931..20943
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.13"
                     /tool="antismash"
ORIGIN
        1 ggtcgcgacg cccgtgcccg acgacggagg agcaccacca tgagcggcgg cacgaccacc
       61 gtgaccgtgt ccacccacat cctggacacc accgccggcc gccccgcccg gggcgtcgcc
      121 gtcgagctgt ccgcccgcgc gaagagcgac gccccgtggg agccggccgg cacctcgacg
      181 accgacgcgg acggccgctg caaggacttc ccggcgctgc ccgccggcac cacccaggca
      241 cggctgctct tcgccgtcga gccctacctt tcccgtgagc gagccgaggg cgcagccttc
      301 ttcccggaag tggcgatcgc cttcgcggtc gcgccgggcg agcactatca cgtaccgctg
      361 ctgctcaatc cgttcggcta ctccgtatac cgagggagct agcgaccgcc atgcccatcc
      421 ttggccagaa ccagtacggc aaagccgagt gccgcgtcct gaaggtcacc cgcgacgggt
      481 ccacccacca cctcaaggac ctcaacgtct cggtggcgct ctccggagac atggaagagg
      541 tccacctctc gggctccaac tcccgtgtcc tgacgacgga cgccaccaag aacaccgtgt
      601 tcgccttcgc caaggaacgc ggcatcgcct cggccgaggc gttcggggtc cacctggccc
      661 ggcacttcgt cgtcagccag cagtccgtca ggaccgcgcg catcaggctg gaggaataca
      721 cctgggagcg catggagacc ccgggggagg gcaggcactc cttcgtccgt acgaaccagg
      781 agacacgcac cgcgcaggtc accttcgacg gccacgcgtg gcaggtgatc tccgggctca
      841 aggacctcgt cgtgctcaac accaccgact ccgagttcca cggctacgtc aaggaccgct
      901 acaccacgct ccgggagacc catgaccgga tcctcgcgac ccaggtccac gcccgctggc
      961 ggcacgcccg gttcgacgac acggtcagat ccccggactg gaacggcagt taccgggccg
     1021 cccggggcca cctgctgacc gcgttcgccg acacgtactc ctactccctg cagcagacgc
     1081 tcttccagat gggctcacgg gtcatcgacc accgccccga gatcgacgag atccgcctct
     1141 cgctccccaa caagcaccac ttcctggcgg atctcgaacc gttcggcctc acgaacgaca
     1201 acgaggtcta cttcgcggcc gaccgtccgt acggcctcat cgaggccacc gtcctgcgcg
     1261 agggcgccga gcccgccgta ccggtggacc tgacgaacct cccgtgaacc gacagcgagg
     1321 aatcaccgtg gccgcacccc cgccggcacc acgcaccccc gaccggatcg tcatcgagaa
     1381 ctgcgccgtc gccaccgtcg acgcccagga caccgagcac ccgagcggcc acgtcgtcgt
     1441 cgccgggaac aggatcgagt ccgtgggcgc ggggccggcg cccgaggggc tcaccggcgt
     1501 cgtccgccgc gtcgacggca ccggtcacct gctcaccccc ggcctcgtca acacccacca
     1561 ccacttctac cagtggctca cccgcggcct cgcccagaac tcccccctct tcgactggct
     1621 cgtcgccctc taccccatct gggcgcggat cgacgaggag atggtgtacg ccgccgcgcg
     1681 gggctccctc gcgatgatgg cccgcggcgg cgtcaccacc gccatggacc accactacgt
     1741 cttcccccgc ggctccggcg acctcctcgg cgccgagatc cgggccgccc gcgagatggg
     1801 cgtgcgcttc agccccaccc gcggctcgat ggaccgcggg cagtcggacg gcggcctgcc
     1861 cccggacttc gcggtcgaga ccaccgaggc cgcgctgatc gccaccgagg aggccatcga
     1921 cacccaccac gacccgtcct tcgactcgat gctgcggatc ggcgtcgccc cctgctcacc
     1981 cttctccgtc tccaccgaac tgctgcgcga ggcggccgtg ctggcccgcc gcaagggcgt
     2041 gcgcctgcac acccacggct cggagaccgt cgaggaggaa cagttctgca aggagctgtt
     2101 cggcatgggg cccaccgact acttcgagtc caccggctgg ctcggcgacg acgtctggat
     2161 ggcccactgc atccacatgg acgacaccga catcgccgcc ttcgcccgca ccggcacggg
     2221 cgtcggccac tgcccctcct ccaacgcccg gatcgcggcc ggcacggccc gcgtccccga
     2281 cctgctgcgg gcgggcgtcc ccgtcggcct cggcgtcgac ggcaccgcct ccaacgagtc
     2341 gggcgagctg cacaccgaac tgcgcaacgc cctgctcatc caccggctcg cgggcggcgc
     2401 ggccgccctg aatgtgcgcc aggtgctgcg cctgggcacg tacggcgggg cacaagtcct
     2461 cggccgggca gcggagatcg gctccctgga gccgggaaag ctcgccgacc tcgtgctctg
     2521 gaagctcgac ggactcggcc actcgaccat cgccgacccg gtcgcggccc tcgtgctcgg
     2581 cgccgccgcg cccgtgaccc tgtgcctggt cgacgggcgg gcggtggtcg aggacgggcg
     2641 gctcgtgacc gtcgacgagg acgccgtcgc gcgcgacgcc cgcgccgcct cccgccgcct
     2701 ggcgcgcatc gcggcagggg actgacctcc gggccggtgc cttccggccc ggcccgaccg
     2761 ctttcgagac tcggccgagg gggacggccc tcggccgggc ccgtggaccc gccgggcccg
     2821 cgggcggcgg accggggcgc ccgcgcgacg gcgccccggt ccgccttcct tccggtgccc
     2881 gcccactgcc caccaccttc gcaacgccgc ctccctgaag ccgtgtcaca tcatcggcga
     2941 cacgaaaacc gacaggagga accgccgtgg ccacagcgcc caggttcacc gagcgaagca
     3001 ccgcacccga cggtgacgac atccacccgg tggaccgtct gctgccgccg gggaagctga
     3061 tagccggcgg attccagcac gtcgccgcca gttacgcagg cgtcgtcgcg ccgcccctcg
     3121 tcctgggcgc gtacatcggg ctctccccgc tggagatcac cttcctggtg ggcgccgcgc
     3181 tcttcacggc gggcatcgcg accctgctcc agacgatcgg gttctggaag gtcggggccc
     3241 ggctgccgtt cgtcaacggc gtctccttcg cgggcgtcgc ccccatgctg gccgtcgcgg
     3301 acgcccagcc gcacaagcgg gacgccctcc cggtcatcta cggggccgtg atcgtggccg
     3361 gggtcctcgg cttcgtcctg gccccctact tctgcaaact catccgcttc ttcccgcccg
     3421 tcgtcagcgg caccgtcatc accctgatag gcatcaccct gctgccggtc gccttcggct
     3481 ggatccaggg cgggcatccg gaacggcccg cctcgctcac cgacctcggc ctggccgggg
     3541 cgacgctggc cgtcgtcctc gggctgcgca gactgctcaa gggcttcctc cagcagatcg
     3601 cgatcctgct cggcctggtc gtcggcaccc tgatcgcgat ccccgtcggc gccgtcgact
     3661 tctcgcccgc cgagcacgcc cggctcgtcg gcttccccag ccccttccac ttcggcgccc
     3721 cgcacttcgc gatctccgcg atcgtgagca tgtgcgtgct catgctggtc tgcatgaccg
     3781 agagcaccgc cgacatgctc gcgctcggcg aggtcgtcgg gcgtgcggcc gacgagaagg
     3841 tcatcgcgcg cggcctgcgc gccgacaccc tcggcaccgc cgtcagcccc ctcttcaacg
     3901 gcttcgccaa cagcgccttc gcccagaaca tcggcctggt cgcgatcacc cgggtgcgca
     3961 gccgcttcgt cgtcgcgacg tgcgggctga tgttcgtcct cctcgggctg agcccggtct
     4021 tcgcctcgct catcgcggtc gtgccccggc cggtgctcgg cggcgcgggc atcgtgctct
     4081 tcggcagcgt ggcggcgagc ggggtgaacg tcctgctcaa ggcgggcctg gaccggggtg
     4141 acaacctgct ggtcgcggcg acgtcgctgg gcctcggcct gatccccgtg gtctcccgga
     4201 cgttctacga caacacggcg atcccctcga ccctgaagat catcctggac tcgggggtca
     4261 gcgcgggctg tgtgacggcg gtggccctca acctgctctt cggcgggacc ggggagaaga
     4321 accccccgga cacacccgcc gtcagccacc ccctcacccc accctcggag caaaataggt
     4381 gaaacccctg caaaggaaga ggtttcgccg tggaccagcc accccaaggc cctgccccca
     4441 cggccgagtc cccgggccgc gggaaattca ccttccccag cgccctcacc gtcctcgcca
     4501 tcgtcacgct cgccgtctgg gccctcacct tcgtcatccc ctccggcacc taccggcgca
     4561 acgacaccgg caagcccctc cagggcacct accaccgcga ggccgcgccc gggaacttcg
     4621 tccaccgcct cggtgacctc ttcctgtcac ccgtcaacgg cctctacggc attcgcgaca
     4681 gcaaaaccgg ccaggtcgcc ccggacgcgg tcggcgcgct ctacggcagc gccggggtct
     4741 tcctcttcgt cctggccatc ggcgcgttca tcacggtcgt cttcgccacc ggcgccctgg
     4801 accgcggcat cgaacggctc gcccaccggc tgcgcgagcg cggcgccctg ctgatcgccg
     4861 gggtgatggc cgtcttctcg ctgctgggca cggtcgaggg cttcgcggag gagaccctcg
     4921 gcttctacgg cctgatcgtc ccgctgatgc tggccctcgg ctacgaccgc atggtcgcca
     4981 ccggcaccat catcctcggc gcgggcgtcg gcgtgctggc ctcgaccgtc aaccccttcg
     5041 ccaccggcgt cgcctcctcg gccgccgaga tctcgctcgg cgacggcatc gcgctgcgct
     5101 tcacgatgtg gatcgtcctc accgccgtga ccatcggcta cgtcatccgg tacgcgcaca
     5161 aggtgcgtgc cgacccgggc cgttccctgg tcggcttcct gcccggcgac cgggagctgg
     5221 cagcggcggc ggaggagccg cccgagctga cgagcctgca gaaggccgtg ctcggcgcgg
     5281 tcgcactggt cttcgccttc atgatcttct cggtgatccc ctggtcgagc gcgctcaccg
     5341 gaaaggccga cgcgaccccg tacggctggg aactcggctg gtccttcgcg cagttggccg
     5401 ccctcttcct cgtcgcggcc gtgatcgtcg gtgtggtggc ccggctcggc gagcaacagc
     5461 tcagcgcgag gatcgtccag ggcgcgggcg acttcatcgc ccccgcgctg accatcgtgc
     5521 tcgcccgggg cgtcaccgtg atcatgaaca acgcgcgcat cacggacacg gttctccact
     5581 ccatcgaagg cgccgtctcg gggaccccgg cggcgctctt cggggtcatg gtctacatcg
     5641 tcaacctgcc gctcgcgttc ctcatcccct cgacgtccgg ccacgccacc ctcgcgatgc
     5701 ccatcctcgc gccgctcgcc gacttcgcgg gggtcgcccg ctcggtggtg gtcacggcct
     5761 gggaagcggc gagcggcgtg atgaacctct gggtgccgac caccgccgtc atcatgggcg
     5821 gcgtcgcgct ggcgaaggtc ggctacgaca aatacctgcg cttcgtctgg ccgctgctgc
     5881 tcctgctgtc cgtcctcgtc tgcggcttcg tggccctggg cgcggtcgcc ggctgagcgc
     5941 gctcaaccgg cgctcattag gggaccatcc cttctgcagc cctcttcggt agggttgtga
     6001 cctctcggtc ccggtgggtg catggcttgt ggcgcgagcc attcgatggc cactgtgagt
     6061 tgtgccagcc ccgccgggcc gaggccgtct gatcggcatc agggacacgc cccgcagagg
     6121 gccgattaat gagcttccgg cagacgtcct caccaccggg caggtgctcc gcgcacgaca
     6181 caggagtact tctttcgtgt tcatcggatg ggactgggcg accgagaccc acgacgtgac
     6241 tgtcatggac aactccggtg cccgagttgc ccgttgggag ctcgcgcaca ccgaggaggg
     6301 catcgcccga accctggcca aactggcgaa gcacggcagt ccggcggatc ttccggtcgc
     6361 catcgagacc acccgcggcc tggtggtgga ccggctgctg gccgccgggc acccggtggt
     6421 gccggtgcac cccaacgcct tccacgcgat gcgtccgcgc tggggcgcct ccaaggccaa
     6481 gacggacgcc ggggacagtc tcaagctcgc cgactacctg cgcaccgacg ggcacttcct
     6541 gccccggctg gagccgaccg agcaggtcac gatggaactg caggccctca cccggcagcg
     6601 ggccgaccac gtcgcggccc gcatcgccgc gatcaaccag ctcgccgcgc tgctggatac
     6661 gcactggccc ggaggcaagg ccgtcttctc cagcctcgac agcgacatcg ccctggcgtt
     6721 cctggagcga taccccaccc cagccgcggc cgccaagctc accgccgggc gcctggaagc
     6781 atggtgcaag cgccgcggct actccggcaa gaagcccgga agcgtcctca tcgaacgcct
     6841 ccggtcctcg ccgaagccgg cctcccggct cagcgacagc gtgatcgcac agctggtccg
     6901 tgtccaggtc cagctggtca agggcatccg ggccacgatc cgctcgctgg acgaggccat
     6961 cgccgacgcg gtcgccgccc acccctacgc acagctgttc gcgaccatgc cccgcattgg
     7021 gacggtcaac ctcgggcaga tcgtcggcga gatcggtccg atcctggaac gctccaagac
     7081 cagcgaacag ttcatcgccg aaaccggcgt cgtcccggtc acccgggcgt ccggcaagtc
     7141 ccgcgtggtg accttccgtt acgcggccaa ccgtcgcgcc cgcctggccg tcgtcggcta
     7201 cgccgacaac agcaggcacg caagcgactg ggctgcgaag atctacaacg acgcgcgggc
     7261 gaacaagaaa cgccatccac acgccgcccg catcctcgcc cgcgcctggc tgcgggtgat
     7321 gtgggcctgc tggcgcaccg gcacctgcta cgaccccgat acccatcggg ccaacaacaa
     7381 gatcaatcag gatcccgagg cggctctggc ggcatagagg ttgactcagg gaactcacag
     7441 ccggatctcc tgcccgtccg aggccacttc caccagcgcc gccgacagca cggaacgctc
     7501 acgggaggcg gggtccgcgg ccggattggt gttgttcagg tgggtgtaga ggcaccggac
     7561 gcccgtacgg ccccgcagcc tggccagcgt cccgccggtg ccgccgatgg ggagatggcc
     7621 catcgcgcgg gcccccgggc cgtgccccgt cgcccgctcc atctcgtcct cgctccagaa
     7681 ggtgccgtcg aggatcgcgc accccacccc ggccagggcg gcgtccagct cctcgggcca
     7741 gcgggcgagg gagggggcgt agacggccgc cgcgcccgtc acggcgtcgt cgaagcgata
     7801 ggccaccacc cacgggccgg gccgggtgga gcccgccgcg tagcgcggcc gcttgtcgct
     7861 cacggggatc gcggtgacgc gcagccgccc gtcgtccagc cgcagttcac ccgcaatcgg
     7921 ccgccagcgc gccgcgccgt acggggcgag caggctgcgc agcgggaagt cctccgtgag
     7981 ggccgtcgtc acggccgccg gggcgaagag gtcgagcgcc gcgccctcgc gcagcgccag
     8041 cagccccgcc gtgtggtcga gctcgccgtc ggtgagcagc acgccgcgca gcggggagtg
     8101 ccgggtgccg ccgggcgggg cgagcccggg ggtggcgagg atctgcgtac ggacgtccgg
     8161 ggaggcgttg acgagatacc aggcgtcggg tgaggcgctg accgccaggc actcctggct
     8221 ccgccacacc gccgggcccg cggcccgcgc ccgggagcag ccggggcagg cgcagttcca
     8281 ctggggcagc ccgccgcccg ccgcggtgcc caggacgcgc agcctcatcg ccggcccgcc
     8341 ctcccgtcag cccagcagcc cgtacgcgtg gagcgcgccg gagaacgtcg gcacgtacac
     8401 cttgccggcg gcgaccgtcg gcggcgcgaa cttcgcgaac atccccacgt cgtcgcgggt
     8461 ggcgttcatc ttgctgttcc acacctcccg ggtcaggtcg gtggcctggt aggcgcggaa
     8521 gacaccctcc accacggcct ggttggcgtt gtcgcggtag gggtgggtcg cccagacgag
     8581 gccggtcgcc gggtcgtcgc cgtgggcgga gacggacagg aagccgccgg gcatcccggg
     8641 cgacccgccg ggcacgcccc tggggtcggt ggtggtgctc gtcgacacgg gggccgtctg
     8701 gaacgtgcca ccggtgaagc ggtaggcccg caggaaggcg ttctccggcc agacgtacac
     8761 ccagggcccg ccgccgcccc ggaagttcca gtgcaccgcc ccgccgtgga tgtgatggct
     8821 gttcctgtcc ggtgtcacca cgaagaagct ctgcacgatc tggctgtccg aaccggcgtg
     8881 gaaatggccc atgttgccgg tgtccagcag atagaacttg ccttccttgc cgccgcccag
     8941 caacagccgg gtgtccggga tcagcagcgg cccggccgat cccaggtcgg cgtcggcggc
     9001 gtccagggcc gcgttgttga agggggagaa ccagtccgcg agcgtgaggc cgggggccag
     9061 cttgacgacg gcgtccccga gctccgaacc gtccggacgg aagccgccgt tgccggtcat
     9121 gaagtagagg ttcccgtggt cgtcgacgcc caggccctgg cccgcctgcc agatgccgcc
     9181 ccgctgggtg ccgggcgtgg tcacgtacac ccccgcgcac cggagatcgc cggcgtcgaa
     9241 gccgaacacc cagccgtggt acggatcctg gtcgccgtag gcggcgaacg cgacgtacac
     9301 ccggccgccc gccaaggtca gcgcggcgcg ctggatctgc cggttgctgg tgaaggtcag
     9361 cttcccctgg gcgctgccgt cacccgtgcc gggcaccgtg gcggtgatcc gcaccggccc
     9421 gcccagggcc tcccggccgg tggacaggtc cagcgcgtgc agggtgtggt ggtacgcgcc
     9481 ctgctccttg gtgaaggcga cgacatggag gacgtgccgc tccacgtcga tgaccggtgt
     9541 gctgaccacc cccacctcga ccgcgatgtc gtggtacacc ggcggcccca cattcgcgtc
     9601 gggcagggtg acggagggcc cgagggaggc gtgccacagc ggtgcggagg ccgtcgggtc
     9661 gtcggcgtcg aaggcgtaga cgctgttgtg catcgtcgcc gtgaagacga cgttgcgcag
     9721 cccgtggccc tcgacggggc actgggcgag atagagcggc tgggcgtaga tctgaccgtc
     9781 caccgggcgg ctgaagagct tgccgaaggt gtccgggcgg acgtttcccg ggtggagggt
     9841 cgtctccagc agattcgcgc cggtgcggcg gttgtcgttg tgctgggtcg tgaccgacag
     9901 cccggccggt ggcagcgggt tcatggcgtc gcctcctgcg ggggccgggt ggtggtgggt
     9961 gcgggcgtac gtgggcgggg acggcgtcga gcgggcggga tcagccgcgg gggagcgcgg
    10021 cgccgggtat ggcctcggcg tcgcggacga tgccctgcac cagcgcgtgg tgcggggaga
    10081 gcgcgcaggc ggggtcggtg gccgcggcgt caccggtcag ctggaacgcc tggcagcggc
    10141 agccgccgtg atcgatctcc ttgcgcggac agctgcggca cggctcccgc atccagtccg
    10201 tgccgcggaa caggttgaac gcctcggagc ggaaccagat gtcggcgagg cccgctcgcc
    10261 ggacggtcgg cacgacgagc cccgggatcc gccccgccgc cgcgcacggc agcacatcgc
    10321 cgttgggcgc gacggtcagc tggcggctgc cccagccgtg catacagggc ttgggcacgc
    10381 cgtcgtgcag gtcggacacc acatagacga tctccagccg ccccgcgtgc cgctcccgtg
    10441 cggcccggat cacggactcg gcggcggtga gctgctcgcg cgtgggcagc agggcccggc
    10501 ggttgagcag cgcccagccg taatactgcg cgttggccag ctccagccgg tcggcccgca
    10561 gccgcacggc cagctcgacc agcgccccgg cctgcccgat attggcgcgg tgcagcacgg
    10621 cgttgagcgt cagcggcagg cccgcgtcct tgacgagcgt ggccgcggcg agcttccgcc
    10681 ggtgcgccgg acggcccgcg agggcgtccg cctccggggc gtcggagctc tgcacgctga
    10741 tctgcacatg gtcgagcccc gcggcggtca gggccgacag ccgggccgcg gtgagggcct
    10801 ggccgccggt gatcaggccg gtgtagagac cgaggccgtg cgcgtgcgcg acgatcccgg
    10861 ccagatcccg tcgcaccagg ggctcgccgc cggacagatg cacctggagc accccgagct
    10921 cacgggcctc ggccagcacc cgccgccact gggacagcgt caactcctcg gcgtaggcgt
    10981 cgagttccac cggattggag cagtacgcgc agcgcagcgg gcagcggtac gtcagctcgg
    11041 cgagcaaccc cagcggccta tccaccggtg tgctccgggg gaccggggga gggctcgatc
    11101 agccgccgcc gcgccagctc cgcaaggaag gcccggacct ccccggcggg caccgacgca
    11161 taggtccgcg ccagggcgcc ggtgagggcg tgctcgtcgg tggcgccgtc gcacagcgcg
    11221 agcacggccg cgcccgtctc gttgagcaac aggacaccct ccgggtgcag cagcacgccg
    11281 gtgtcccgga cggtgtcgtg gccgagccgc acgccaccgc gcagccgcca ccggaccccg
    11341 gcgtccgccg tgggccccgc cggcccggca ccgcccggcc tcaccgggcc cggcccgcgt
    11401 gttcgagggc gtcgaggatg ctccacagca catcgcactt gaacgccagc gcggccaggg
    11461 ccgcctgctg tcgctcccgg gtcgtgcagt gggcgaggac gagctccagg gcatgccggg
    11521 cgtcgcaggt ggccgcggcg gggcgctcgg cgaaataggc gtggccggac gcgctgaccc
    11581 aggggtagtg cgtgcgcagc gcggcgaggc gctcgcgcat caggtcgggt gagaacagct
    11641 cggtgagcga ggaggcgacg gcctcggtcc aggggcgggt gcgggcgaag gtcacatagg
    11701 cgtcggtggc gaagcggacg ccggggagca catggcgctc gtccagcacc tccgagcggc
    11761 tcaggcccgc ggcctcggcg aggtccagcc actgggcgtg cccgccgtgc cggtcgtcgg
    11821 tgccgtcctg atagaggacc cgctgcaccc agcggcggcg cacctcggcg tccggacagt
    11881 tggcgaggac ggccgcgtcc ttctgcggca ggcacttctg gtagtaccag cggttggcga
    11941 tccactgccg cagctcctgg cggctcagct cgccgcggtg gaggcgcagg tgcagcgggt
    12001 gcttgtgcca gtagcggtcg gagtgggcgc gcagcgcggt cgtgaattcc tccgtgctcc
    12061 aggcggtggt catcaccatc gcccggcgta ggccgtgacc tcttgaccga gctcgatgtc
    12121 cgcgaaggcg ggcggcagcc agggccggag cgcgggcccg ccggggctct cgcggtgtgc
    12181 gggacggccc tgccgcgccg tgccggtgcg cgggaccgcc gtcgtcgaac cggggcccgg
    12241 gcccgggccc gacgatcgcg cgacgggccg gggactgctg gtcgttgccg cttcggccat
    12301 ggtggctccc ccgtcgtccg cgagtgcagg gcgaccggcg ggtgtgccct gctcccttcc
    12361 agggtgagcc agggcacaca tgagccacaa tcactgaatc gggtgaacaa tcatccaatc
    12421 acccgtcaca tagggctgtt tcgcccctcc ggtcagggca ttcccgccct caggccggcc
    12481 ggtcgagcag ctcgtacgcg ggcagggtga ggaactccgt gtagtcctcg tccagggcga
    12541 ccttcagcag caggtcgtgg gcctgctgcc accggcccgc ggcgaaggcc tcctccccgg
    12601 cctcggcgcg gatcgcggcg agctcctcgg cggccacccg gcgggccagt tccgcggtgg
    12661 ccttctcacc gttgccgaac accaccccgg cgttgatcca ctgccagatc tgcgagcggg
    12721 agatctcggc ggtggccgcg tcctccatga ggtggaagat ggcgacggcg cccgagccgc
    12781 gcagccacgc ctcgatgtag cggatgccga ccgccaccgc gttgcgcagc ccctcgtacg
    12841 tcggcttctc ctccagcgag tcgaccgcga tcagctcggc ggccgtgacc cgtacgtcct
    12901 cgcgcagccg gtccttctgg tgcggccggt cgccgagtac cgcgtcgaac gaggcccgcg
    12961 cgaccggcac caggtcgggg tgggcgaccc acgagccgtc gaagccgtcg cgggcctcac
    13021 ggtccttgtc ggcgcggacc ttctcgaacg cggcctcgtt gacctcgggg tccttgcggg
    13081 aggggatgaa ggccgccatc ccgccgacgg cgtgcgcccc gcgccggtga catgtgcgca
    13141 ccagcagctc ggtgtacgcg cgcatgaacg gcgccgtcat cgtcacggcg ttgcggtcgg
    13201 gcaggacgaa gcgcggcccg gcgtcgcgga agttcttgac gatcgagaac aggtagtccc
    13261 agcggcccgc gttcagcccc gaggcgtgct cgcgcagttc gaagaggatc tcctccatct
    13321 cgtacgcggc ggtgatcgtc tcgatcagga cggtggcgcg gaccgtgccc cgggggatgc
    13381 cgacgtggtc ctgggcgaag acgaagacgt cgttccagag gcgggcctcc aggtgcgact
    13441 cggtcttggg gaggtagaag tacgggccct tgccgaggtc gatcaggcgc cgggcgttgt
    13501 ggaagaagta gaggccgaaa tcgaccaggg cgccggggac ggggcggccg tcgacggtga
    13561 ggtggcgctc gtccaggtgc cagccgcgcg ggcggaccac gacggtggcg agctcctcgg
    13621 ccggccggag cgcgtacgcc ttgccgcggt cgtcggtgaa gtcgatgcgg cgctcgaagg
    13681 cgtcggtcag gttgagctgg ccccgtacga cgttctccca ggtgggcgcc gaggcgtcct
    13741 cgaagtcggc gagccagatc cgcgcaccgg agttgagcgc gttgacggcc atcttgcggt
    13801 cggtcgggcc ggtgatctcg acccgccggt cctggagcgc cgccggggcg ggcgccacgc
    13861 gccagctgtc gtcctcccgg atcccggcgg tctcggggag gaagtccagg gcggcgctcc
    13921 gcgcgatctc cgcgcggcgt gcggcgcggc gggcgagcag ttcgtcgcgg cgcggcgtga
    13981 accggtggtg cagcgcgccg acgaaggcga gcgcctcctc cgtcagtacc tctgcctgct
    14041 gctccacggg aggggcgtcg acgatgaccg gcgaggacgg cgctggtgcg gacatggact
    14101 gtcactcctt cagcgaggac ggcacgcagt gccgcgcgaa tcctgatcaa tggagaatag
    14161 ttttctcatg gtggaagttc aatggggcgt ggtggcgccc ggtgccaggc cccgcgcccc
    14221 cgcggaagcc cgaactccgc gccccctgcc cgccaaccct cagtccagga gccgcagatc
    14281 gtccggggtg tcgacgtcgt ccggcgccgc gatgtccgcg cactccacca gcgtcacctc
    14341 cgcggcgtgc tcgcgcagat acgcgcgggc gccccggtcg ccgacggccg aacgcgccac
    14401 gcccgcccag tgctcgcgcg cgaacagcac cggatggccg cgctcacccc cgtacgcggc
    14461 cgcggccagc cccgcgcccg cccggtgcgc ggccaccagc cgggccaccg cctcggcccc
    14521 cacgcgcggc tggtccacga gcgtcaccag caccgccgag acgtccgtcg aggccagcgc
    14581 cgcgagcccg gcccgcagcg atgaccccat gccgtcggcc cagtcggggt tgtccaccag
    14641 gacgcagtcc ggcagttcgg cccggccgcg cacatccgcc gcggccgcgc ccagcactac
    14701 gtaccgtggt acgcagccgc cgtcccgcag cacccgggcc gcgaactcca ccagcggcct
    14761 gcccccgtgg ccgagcagcg ccttgggccg gccacccagc cggcgcccgc cgcccgcggc
    14821 cagcagcagc ccggcgacgg gcaccgcccc gggggtgtct gtcgtgtccg tggtccgcgt
    14881 catgacccct gcataccgca tccgttcgcc ctgccgggcg gaggccggtt cgtcacccgt
    14941 gcgtgcggag tacggactta atttcgctgt gcgtatagcg cgctgtacgg aaagtgcgtt
    15001 aactgatcgg cgcgagcgcg tgggaggggg agtgtcgtgg cggaaggcgc cgttgtggtg
    15061 gaagaggagc gagtggaccg cgtcggtcag gaccctaggg tggacgcgtt gagggacgcg
    15121 gtgtcccggc tgcgccgggc gctcgcggca cacccggccc ggttacccga ccgggacgcc
    15181 gccgaggacg aactggccgc gctggacgcc atggcgcgcg agggcgaacc cgaagtgccc
    15241 cggctgcgcc gctccctgct gctggtcgcg ggcgccgtcg gctccgtcag cgccctggcg
    15301 gcggccctcg ccgaactccg cgccgcggtc gaccggttcg gcggcacacg ggtgccggag
    15361 cagggctcgg gaaggcccct ggacgaggcc gcgcgcggtg ccccggaaga gggcgcgcac
    15421 cgcgtcccga gcccccggga agcccccgga gaggactgag ggcatcgccg gccggggtca
    15481 ggcggtggcc gccagcgcca gcgacagctc cgcggcgacc tcctggagca gcggcacgat
    15541 cttctccgtg gccgcgtccg tcacccggcc cgcgggaccc gagatggaga tggcggcgga
    15601 cgtgggggaa tcgggcaccg gcaccgccag gcagcggacg ccgatctcct gctcgttgtc
    15661 gtccaccgcg tagcccgact cgcgcacccg ggccagcgcc tccaggaaga cgtccggcgt
    15721 ggtgatcgtc ttctcggtcg cggcgggcat gcccgtacgg gccagcagcg cccgcacctc
    15781 gtcgtccggg ctctgcgcga gcagcgcctt gccgacgccc gtggtgtgcg gcagcacccg
    15841 gcggcccacc tcggtgaaca tccgcaccga gtgccgggac ggcacctgcg ccacatagac
    15901 gacctcgtcg ccgtcgagca gcgccatgtt cgccgtctcg ccggtctcct cgaccagccg
    15961 ggccaggtgc gggcgggccc aggtgccgag cagtcgggac gcgctctcgc cgagccggat
    16021 cagccgcggg ccgagcgagt accgccgatt gggctgctga cgtacataac cgcaggccac
    16081 cagcgtgcgc atcagccggt ggatggtcgg cagcggcagc ccgctggtcg tcgacagctc
    16141 gctcagcccg acctcgccac cggcgtcggc catgcgctcc agcagatcga aggcgcgctc
    16201 cagtgactgg acaccgccac tggtcgggac ggttcggggg tcggcgggcg agggcacgtc
    16261 tgggtccttc cggtacaggg gtggcagcag cctaccggga catcgagggc tttacgcccc
    16321 accttccaca atttgaaaac cgacttctgg tgcatgaaat gcgcaagggg tcggggggtc
    16381 ttgacgggta cgggacacgg ctgaagactg cgtgcaccgc ggttcaacag aacgttgaaa
    16441 ttccggctcc aagggcccga agggcccgcc ggaggagggt gcgtgctcgt ggccgcaacc
    16501 gatacgaggg tcccggtgcc accggtggag ctggtgctgc gctccacgcg cgtcgtcacc
    16561 ccggaaggcg tccggcccgc ctccgtcacc gtcgccggcg gccggatcgc ggccgtcctc
    16621 ccgtacgcga ccgggcccgg acccggccca ggcgcggtcg gcgggccgta cgggaccggg
    16681 gccgtcgtcg aggacctcgg tgacgacgtc ctgctccccg gcctcgtcga cacccatgtg
    16741 cacatcaacg accccggccg caccgagtgg gaggggttcg cgaccgccac cagggcagcc
    16801 gccgccggtg gcatcaccac cctcgtcgac atgcccctca acagcctccc gcccaccacc
    16861 accctcgaac acctgcggac caaacagggc gtcgcgtgcg acaaggccca cgtcgacctc
    16921 ggcttctggg gcggcgccct gcccggcaac ctcgcggagc tgcggcccct gcacgacgcc
    16981 ggggtcttcg gcttcaaggc gttcctctcg ccctccggcg tcgaggagtt cccctcgctc
    17041 ggccccggcg acctggaggc ggtcgcggcc cggatcgccg ccctcgacgg actgctgatc
    17101 gtccacgccg aggaccccgg ccacctgcga cgcgccccgc gaccggacgg accgcgctac
    17161 tccggcttcc tcgcctcacg cccccgcgcc gccgagaacg aggcgatagc ccggctgata
    17221 tccgtcgccc gccgactggg cacccgcgtc cacatcctgc acctgtcctc gtccgacgcc
    17281 ctgccgatga tcgccgccgc caaggccgac ggggtgcggc tcaccgtcga gacctgcccg
    17341 cacttcctca ccctcaccgc cgaggaagtc cccgacggcg ccaccgagtt caagtgctgc
    17401 ccgccgatac gcgaggccgc caaccgggac gccctgtggg ccgggctcgc cgacggcacc
    17461 atcgactgcg tcgtctccga ccactcgccc tgcaccaccg acctgaaggt ccccgacttc
    17521 ggccgcgcgt ggggcggcat ctcctccctc caactgggcc tgcccgccgt ctggaccgag
    17581 gcccggcggc gcggccacac cctccacgac ctcgcccgct ggatgtccgg cggccccgcc
    17641 gccctcgccg gcctgagcgc caagggcgcc gtcgaggcgg gccgcgacgc cgacttcgcc
    17701 gtcctcgccc ccgacgagac cttcacggtc gacccggccg cgctccatca ccgcaaccac
    17761 gtcaccgcct acgccgggaa gaccctgcac ggcgtcgtac gggcggcctg gctgcgcggc
    17821 cgccggatca ccggccacgg cggccccacc gagcccaccg gcctcctcct cgaaaggcag
    17881 cgcagcgcat gaacggcacc cccgcggaca taccctcgtt caccggcgac gcgaatccct
    17941 acgcgggcgg cgacccgtac gccgactacc gcaccgcggc cttccccttc gaccggttcc
    18001 ccgacctcgc cgaccggcgg ctgggcgccg gggtgatcgc cgccaacgac gagttcttcg
    18061 ccgagcgcga gaacctcctc aagcccggcg ccgcgcactt cgaccccgaa cacttcggcc
    18121 acaaaggcaa gatcatggac ggctgggaga cccgccgccg ccgcggcgcc tccgccgcca
    18181 ccccgcaccc ggccgacgac gacctcgact gggcactcgt ccgcctcggg gcacccggcg
    18241 tcatccacgg catcgtcgtc gacaccgccc acttccgcgg caatcaccca caggccgtcg
    18301 gcgtcgaggc caccgccctg ccgggcacgc cctcaccgga ggaactgctc gccgacggcg
    18361 tgaagtggac ggtcctcgtc ccccgcacgt ccgtcggcgg ccacgccgcg aacggcttcg
    18421 ccgtcgactg cccggagcgc ttcacccacc tcaggctcag ccagtacccc gacggcggca
    18481 tcgcccgcct ccgcgtccac ggcgaatccg tacccgacct cgcctggctc gcggccctcg
    18541 gcaccttcga cctcgccgcg ctggagaacg gcggccacgt cgaggacgcc tccgaccgct
    18601 tctactcctc ccccttccac accatccacc ccggccggtc gcgccgcatg gacgacggct
    18661 gggagacgcg acgccgtcgg gacaacggac acgactgggt gcgctaccgc ctcaccggtc
    18721 gcgccgagct gcgggcgatc gagatcgaca cggggtgcta caaggggaat tcggcggggt
    18781 gggcgacggt ttcggtgctc gatgccgcga actcctccgg gtggacggaa gtcgtgcctc
    18841 ggacgcggct tcagcctgat gcggtgcatc ggtttgtgct gccggggcct gtggtggcga
    18901 cgcatgtccg tctggacatc caccctgacg ggggtgtggc gcggctacgg gtgcacggtt
    18961 cgctggtgtc ttgattttcc ccagccccgc cccttcccga aaccggggct cgtgccccag
    19021 gcccccggct gcgggtccgt tgccgcctgc ggcggagagc gccctgcggg cgcgtcctca
    19081 aacgccggac gggctggaat cagcccgtcc ggcgtttgag gacgagcggc gaagccgctt
    19141 tcggggtctg gggcggagcc ccagtttcgg gaaggggcgg ggtggggaac aaagcccgcc
    19201 gcaggcgcaa cagacctgca cctcaaggcc gtcgatcaga accgcacggg aacccaccgc
    19261 ggcccccgaa taagcaggcc ctcccgccag gccagagccc ccggatggac atccagcgcc
    19321 agttccggga agcgctccag cagcgaccgg atcgcgatcc gcgcctccag gcgggccagt
    19381 ggcgcgccca ggcagtagtg gatgccgtgc ccgaaggcga cgtgtccgcg ggcgtcgcgg
    19441 cggatgtcga agcggtgcgg ctccgggaag cgggcggggt cgcggtccgc gtcggcgagg
    19501 acgggcagga cgagcgcgcc gccgcccggg atgctcacgc cgccgatctc caccggctcg
    19561 gtggtgaacc ggtaggtcgg cgtctccacc ggcccgtcgt agcgcagcat ttcctcgacg
    19621 gcgttctcca gcaggccggg gtcggcgcgc agctccgcca gctggtcggg gtgttggagg
    19681 agggccagga cgccgttgga gatcaggttc acggtcgtct cgtgcccggc gacgagcagg
    19741 agccaggcca tgccgaggag ttcgtcgggc gagagccggt cgccgtcctc gtcggtggtg
    19801 cggatcagcg cgctcagcag gtcgtcgccg ggctcctcgc gcttggctgc gacgagctcg
    19861 gtgaggtagg cgcggcccgc gctcgaggcg acggccttct cctccagcgg cgcggacccc
    19921 accgcgatgt cggaccaggc gcgaaaggcc tcccggtcga gggagggcac gcccagcagc
    19981 tcgcagatga cgcccatggg cagcgggaac gacagggcgt cgacgaggtc ggtgcggcgg
    20041 tcgggggccg cggccatcgc gtcgagcagc tcgtcggtca tccgctgtac ctgaggggcc
    20101 atcgcctcga cgcgcctggg ggtgaactcc ttggtgacga gcttgcgcag ccgggtgtgg
    20161 tgcggggcgt cctggatcag catgtgcggg cccgaggcca cgggtatgag cccgacgtcg
    20221 tcggcggccg tcagccagtc cttcgacagc cgtgggtcgt tgagcgtcgc gcgcacctcg
    20281 tcatagccga cgacgagcca ggcctccgcg ccctcgggca tccgcacccg gtgcacgggg
    20341 ccgatcgcgc gcagttcggc gtagacgcgg tacgggtctc tggcgaactc ctgccccatc
    20401 gccgccaggt cgaccagctc gccggtgtcc gtactcatgg ttgccccctc acgttgacca
    20461 agatcaccac agtactccgg gcggtcgatg gtcgaacagg gcggcgctgt cggcgggttg
    20521 gccctgcggc cggtcaggga taggaacgca gatacgccgc attcgtggtc gcgtcggacg
    20581 gccctccggt gtcgttgacg atgtgccgga tggtgcccgt gccgccgagc gagaccgtga
    20641 ccaggtcgtg gaagcgcacc ccgggccgcc ggggcgccgc gaaggcccgg tcggccacca
    20701 cgcgcggatc ggcggtgaag tggccgtaac tgcccatccc ccagccctcg tgccgcgtca
    20761 cccggccgcc gacctcgtag gcggggtacc ccttggtggc accccggctc caggcggcct
    20821 gggagggcgg gtcgtagggc agctcgttct ggaagaagta cgtacggccg tcctcgccgt
    20881 tccagacggt ctgccggcgc tggtagtgct cgacgaacag cccgtacatc gtgacgcggt
    20941 caccgttcac gaccaggccc tcggcggcgg tgttggcggt ccagccgacg ccggtgccgt
    21001 ggtcggcgcg ccacagccac aggtcgtcgc cgatgacgtc cgagctgttg acgacgaggg
    21061 tacggaccgc cttgccgacg cccgcgccgc cgacgcggaa gaacacgtcg tggagcgaga
    21121 cggggtcgcg ctcgtgccgc cggcgggcgc cgggcggccc gatctccatc agggcgggcg
    21181 aggcgacggg accggcgtcg acgaggaggc cggcgatgcg gacgccgtcg acgtcggcga
    21241 cggacagggc ggtcgcgccg tgttcgggga cgagggtcgc gagtcccagg ccgaggacga
    21301 ccgtgccggg acgggtgatc cgcagcgtcc ggtcgaggtg gtggacgccg ggggtgagca
    21361 gcaggtcctt gccgtgtgcg agtgccgcct ggatccgccc ggcgggcgtc ccgggccgca
    21421 cgacgaggaa ccggtcgagc ggacgcgagg agcccggctg ccgggcgccg cgttcccagg
    21481 tggtgcccga ggtggcggtg cgcagcgcgg gtacgaagac gcggcaggcg cccgcgcggt
    21541 cgacgtagag gaacggcttc tcgcgtacgc ggggtgtccg gtcgacccgg gtgtagggag
    21601 ggcgggggaa ggtgcccgcg ggggcgttcc gtacgccgac gaacaccatg ttccaggtgc
    21661 caccggtcca gccgccgaag tggctgtccc gggacagcca ttgctgctgg gtgcccgagc
    21721 gcacctgtcc gtcgatccgc gagtcggcga ggaagccgcc gctggcccag cccccgtcgt
    21781 cgagccgcag gtccccgcgc aggtgcatcc ggcggtacgg ggcggcctgg gacaccgccc
    21841 agcggtcggc gccggaggcg ggggtgacgg agaggttctc ggcctcgcgc cagaagttct
    21901 gggtggcgtt gccctggaac cagtcggcct ccgcgtgcac ggctccccgg atcgtgacgt
    21961 cgtcgggcga catccccagg cccgcgacct gggtggagaa cccgacgttg acgtcgacgt
    22021 cgtaggtgcc cggtttgaac agcagcgcct gccgggcggg cccgaactgg ttg
//
