LOCUS       NZ_CP031455            22646 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces olivoreticuli subsp. olivoreticuli strain ATCC 31159
            chromosome, complete genome.
ACCESSION   NZ_CP031455
VERSION     NZ_CP031455.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivoreticuli subsp. olivoreticuli
  ORGANISM  Streptomyces olivoreticuli subsp. olivoreticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Complete genome sequence of Streptomyces olivoreticuli ATCC 31159,
            producer of anticancer bestatin and diverse secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2018) Tianjin Key Laboratory of Food
            Biotechnology, College of Biotechnology and Food Science, Tianjin
            University of Commerce, NO.409 Guangrong Road, Tianjin, Tianjin
            300134, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-JUN-2018
            Assembly Method                   :: SMRT Link v. 5.1.0
            Assembly Name                     :: TJCU_BT_311
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: SMRT Link v5.1.0
            Genome Coverage                   :: 145.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003391135.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 04:49:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,562
            CDSs (total)                      :: 7,459
            Genes (coding)                    :: 7,276
            CDSs (with protein)               :: 7,276
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 183
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 183
            Pseudo Genes (frameshifted)       :: 61 of 183
            Pseudo Genes (incomplete)         :: 150 of 183
            Pseudo Genes (internal stop)      :: 18 of 183
            Pseudo Genes (multiple problems)  :: 41 of 183
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:12:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1579075
            Orig. end                         :: 1601721
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Hongyu Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22646
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="16"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22646
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22646
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12646](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12646)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    21..36
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.47"
                     /tool="antismash"
     gene            306..1358
                     /locus_tag="DXZ73_RS06940"
     CDS             306..1358
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (21-273). E-value: 8.7e-13.
                     Score: 40.0. Matches aSDomain:
                     nrpspksdomains_DXZ73_RS06940_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604246.1"
                     /locus_tag="DXZ73_RS06940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_116215460.1"
                     /sec_met_domain="ADH_N (E-value: 1.3e-26, bitscore: 91.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-18, bitscore:
                     66.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHTTVPAYAAPAPKAPLERTTIERREPGEHDVLIEIKYAGICHS
                     DIHTARAEWGEGTFPVVPGHEIAGVVTAVGTGVTKYALGDRVGVGCFVDSCRECDNCEA
                     GLQQYCTGASGMVGTYGATGRDGEITYGGYSTHIVVDENYVLRIPDSIPLDAAAPLLCA
                     GITLYSPLAHWQAGPGKKVAVVGLGGLGHMGVKIAHAMGAEVTVLSQSLRKKDDGERLG
                     ADHFHATSDPATFTSLAGTFDLIVNTVSADLDLGAYLSLLKTDGTLVQVGAPEKPLPLA
                     AFALIQGRRSLAGSMIGGIPETQEMLDFCGEHGLGADIEVIGADRINEAYERVLASDVR
                     YRFVIDAATI"
     aSDomain        369..1124
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DXZ73_RS06940_PKS_ER.1"
                     /evalue="8.70E-13"
                     /label="DXZ73_RS06940_PKS_ER.1"
                     /locus_tag="DXZ73_RS06940"
                     /protein_end="273"
                     /protein_start="21"
                     /score="40.0"
                     /tool="antismash"
                     /translation="TIERREPGEHDVLIEIKYAGICHSDIHTARAEWGEGTFPVVPGHE
                     IAGVVTAVGTGVTKYALGDRVGVGCFVDSCRECDNCEAGLQQYCTGASGMVGTYGATGR
                     DGEITYGGYSTHIVVDENYVLRIPDSIPLDAAAPLLCAGITLYSPLAHWQAGPGKKVAV
                     VGLGGLGHMGVKIAHAMGAEVTVLSQSLRKKDDGERLGADHFHATSDPATFTSLAGTFD
                     LIVNTVSADLDLGAYLSLLKTDGTLVQVGA"
     CDS_motif       495..530
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DXZ73_RS06940_0001"
                     /evalue="6.00E-04"
                     /label="PKSI-ER_m2"
                     /locus_tag="DXZ73_RS06940"
                     /protein_end="75"
                     /protein_start="63"
                     /score="12.7"
                     /tool="antismash"
                     /translation="GHEIAGVVTAVG"
     gene            1542..2321
                     /locus_tag="DXZ73_RS06945"
     CDS             1542..2321
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004946513.1"
                     /locus_tag="DXZ73_RS06945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_116210136.1"
                     /transl_table=11
                     /translation="MLTTDFVTGAPNWLDLGSPDTAASAAFYSPVFGWDFESAGPEAGG
                     YGFFQKDGRTVAALGPLTEEGASPAWTVYFRTPDADATAKAVEQGGGTVRVAPFDVMDA
                     GRMACLTDPSGAEFSVWQPAAVKGLEAASESNTLCWAELHSADPTAAFSFYRSLFGWRS
                     QEMEAGGMAYTVLSTAEGDQQDASFGGLVAADEDSETRWIPYFSADDADAIVTRVQENG
                     GSVLMPAADVPDVGRIAWLADPFGAPFAVIKPIPPAA"
     gene            complement(2374..3000)
                     /locus_tag="DXZ73_RS06950"
     CDS             complement(2374..3000)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004944171.1"
                     /locus_tag="DXZ73_RS06950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L25/general stress protein
                     Ctc"
                     /protein_id="WP_116210137.1"
                     /transl_table=11
                     /translation="MAEVKLTAELRTEFGKGYARRIRRDKKVPAVVYGHGADPKHVAID
                     GHALMMALKTPNVLINLDVEGKKELVIPKAVQREALRGFLVHVDLLTVKKGEKVTVEVP
                     VHTEGELAPGGNLLEHILNALPVEAEATHIPEGFTISIEGMEAGHTIRAKDIPLPRGTS
                     LAIDGEDAVLQVVAAQAEEPAEEEEEAEEGAAAPEAAAEGEAEES"
     gene            complement(3231..3596)
                     /locus_tag="DXZ73_RS06955"
     CDS             complement(3231..3596)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS06955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162890093.1"
                     /transl_table=11
                     /translation="MHLWTVTIVSDRYPAPGRMELHCSEPGCRPDPVPLPAPSAARTAA
                     AGHLAWHGRRLEAAPAGARCACRAEAVHRVITHSEAGRVWCLTALCAPCAESLPDARVL
                     RPLNLRDGAPPHGAAPG"
     misc_feature    complement(3303..3305)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3820..5904
                     /locus_tag="DXZ73_RS06960"
     CDS             3820..5904
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004944047.1"
                     /locus_tag="DXZ73_RS06960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_240351244.1"
                     /transl_table=11
                     /translation="MAQLTPRLPGPFELYESPAWAAAAARQGASGAFPEWSRFARLADG
                     TFDEDADPTRDMKPVIAALKSQNVNVIELDTIMSNWITEADFTQHLGKIKSFVELAHGA
                     GIRVVMYYPSLEVISVGGENGRSFYKNGDGKSWVQRGLDGKPNVFYGSLVVWVDPGDES
                     CWVSPNSPWRDFYLGRIKALAGTGLDAVWPDVPIYFDGAISWCDTSTWAADAFRADTGL
                     ALPTKADFGSLPFRRYVEWRHRNLLQWQLDIAAAGRSVNPDLVTFVETVSMDYQYATLV
                     GLDGAYLRKAEGVSHVWEVDILGNYDGMRHATATDWTCLISMYKYARAASGTKPAWAFS
                     YGWQADDASLVMAELLAAGCNPYEVKSPFKNDTTDKAMRTRMYAFVAANQEKLYNSAST
                     AAVGVYHSSASRDFVSPAVGTGMYVNTRKPSGVKEWWASGSAEESCTNQQWLGEFRGTV
                     KALVFAHIPFDTVTSPGLAAADLAGLRVLMLPNLQAVSDAEAGVLRDFVAGGGTVVITG
                     PAPSALDEFGTARSEYALADVLGFRKADPLPTSKQNRFGSGTCRYVQKLVGKSYLASTD
                     QASADQLLGPVTAAAPPEVTLSGDPRIHLEVRRLGADTVVQLVNFTGFGDTPAAFKTAP
                     TSCTVSLALPAGRRVLAATVSSPDGPSPAPQPVDWRLVGATANVTLTVNQYALLTVTTG
                     "
     gene            complement(5919..6956)
                     /locus_tag="DXZ73_RS06965"
     CDS             complement(5919..6956)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004944043.1"
                     /locus_tag="DXZ73_RS06965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TolB family protein"
                     /protein_id="WP_116210139.1"
                     /transl_table=11
                     /translation="MRSRLAVVAFLAALVLTACGSGGGSPRPPAPSDGRTARGDGAQLL
                     YRGQGRASAQNPAFSPDGTSVLFTLFHDGYNEGAAALRVLPIGNGASARPGTLLDESDR
                     AAVNLPGSSWHPSAGVAFASDRAGRDEVWVLPPGGHRPTRVTEHRGDTGYLEPSFSPDG
                     SWIVFQESVEKENGGRESDDDPSALGSLWKVRRDGSEPTRLLDGPATRTDNRQPNWSPK
                     GDRLVFQRRAADSEDWALYVMNADGTGLRRLTDGPGEHTDPSWSPDGRSVVFSSTAGGL
                     DTPQIFVIPADGGKPTRVTRNGGGYDGAPSWSPDGRWIAFEARSGDEDRPTSLWRIPVP
                     GPAKP"
     misc_feature    6994..7008
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.23"
                     /tool="antismash"
     misc_feature    complement(7077..7092)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            7251..8480
                     /locus_tag="DXZ73_RS06970"
     CDS             7251..8480
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="DXZ73_RS06970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_162890094.1"
                     /sec_met_domain="p450 (E-value: 1.7e-19, bitscore: 68.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDRTAAPPGVFTPAFFQDAHPVFDTLRSRAPATLVTGVSGTRL
                     WLIPRYEEARRLLSSPSVRKDDWKRPDLREQHLVRTERRREMSTRIRANMINTDPPEHQ
                     RLRQGTQQALSRGRIEALRPRIDLFADETLGELDAAGDVGPVEFRARIAYPFTVAVVSE
                     LLGLREDEQPGFPAWFDTLMCRRGTENARQTSLILADFSERLDHRRRAHPARGLLSTLG
                     SKPDRRRPLSRTELASTAFLLLIAGIETANAISNGMFALLSHPEQYEALRADRSLLTGA
                     IEECLRHDGPFRAVGPRYTAERVDLEDGVSIPAGEFLLIAVSAANRDPRRFPDPHRFDI
                     TRTDHQHLAMGHGAHRCVGALLAYTEMEILFDKLLDRFPRLRLAVPVPEIRRRPSMTMN
                     WLQDLPVLLR"
     gene            complement(8516..9736)
                     /locus_tag="DXZ73_RS06975"
     CDS             complement(8516..9736)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="DXZ73_RS06975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_240351245.1"
                     /sec_met_domain="LANC_like (E-value: 3.9e-36, bitscore:
                     123.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADGHWAAVLHGSTAAAALDLATALAGRPRPVPRRVRPDLAAGGP
                     GLALAYHQLDRCLPGRGWGAMADGYLAAAVRGAEREGPAFPGLHGGLGGIAFAARSLTP
                     PGADPLPEVHDAVLRSTSLRIKALGDAPHGVPVRVFDLISGLTGTGAYLLCRHHEPASR
                     AALHAVLTGLVALSGERDGTPHCLTPAEHIGDAATRALFPGGVLNFGMAHGISGPLALL
                     SSAVSAAVTVPGQREAVERLAARLASGRTDDEWGPHWPGRVGPDGRPAAEGRAPATWCY
                     GGPGIARALWLAGTALQDARLCDLAVRALRAVHRRLAARPDAECAAGLCHGTAGLLQVT
                     VRFVQDTGDAELRRAAAGPAGRLLGCRAALPAAGPGFLDGAAGVVLALLAAATDVEPVW
                     DRALLLA"
     misc_feature    complement(9368..9370)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9820..9951)
                     /locus_tag="DXZ73_RS40040"
     CDS             complement(9820..9951)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS40040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_275898570.1"
                     /transl_table=11
                     /translation="MENEVLQLQELPETDERELEPMMCCDTDHTSGQCTDPPRCRPS"
     gene            complement(10001..12646)
                     /gene="lanL"
                     /locus_tag="DXZ73_RS06980"
     CDS             complement(10001..12646)
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="DXZ73_RS06980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_240351246.1"
                     /sec_met_domain="Pkinase (E-value: 8.9e-16, bitscore: 56.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.3e-40, bitscore:
                     136.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALSYQSITLRALRDKGPDWTLRDGATWCMVTPPRHDRRPQGWKL
                     HLSATPASAPHVLERAAPVLVAHGCAFKFAVSPRVAAELTSVRASRAQSGKFLTAYPAD
                     DDQLRVLAEELHRATLGLAGPTILSDRRYRPDSLVHYRFGCFARPHELGDEGFYEGRLQ
                     APDGTFVTDTRNPWFEPPPWAASPFDPPAPGRPRGGPVLLVGRYLVREAVRHSNRGGVY
                     RAHDRRTGEDVLLKEARPHIGAGLDGKDARDWLRYEATVLARLAPHRVTPAVREVFEAA
                     GHVFLVEDLIDGKSLQQWAAEHAWRDSGRLPVPTAWELARELTRLMGEVHTAGFVLRDF
                     KPGNVVIGPDGTPVLVDLECAVRADATAYVAGTHGFTAPEYLDGPGRDSDTPPPAPGPE
                     ADCYSLGATLLHATTGISPVLAPDTPPGRTAGDRLAALVDAAAPAFPALRALAPLVLGL
                     TADGPSRWPLEKAAAFLRADPVVRPVTAGPALTPRRTDRLIGDGLAHLAATVEPSAEYL
                     WPGPRALPYGDPCNVQLGAAGVLAVLDRAVRTGEMPAEPLLRTTAQWLDERLTLPSRIL
                     PGLYFGRSGAVWALHGAARTLGDTLLAERAREYALRIPLDWHNPDICHGLAGAGLAQLH
                     LWHTTGDRRFAERASECADGLLRLTAHADRGVDWAAGPEHRTELAGSAFYGFGHGVAGN
                     ATFLLAAGRDLARPELVDIAAGGGHALCAVAERHGDAAHWPKGPGRAERTGLDFWCNGT
                     SGVGTFLVRLWQATGEARFRTYAELAAVAAHRDRWRVGPGTCHGVAGNAELLLDLAEAT
                     GEERYRTWAEEAATCLYPRAVERDGRLVVPDDTLREVCASYNVGMSGVLDFLLRLKHGG
                     PRSWLVDCGH"
     gene            12819..13703
                     /locus_tag="DXZ73_RS06985"
     CDS             12819..13703
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004945137.1"
                     /locus_tag="DXZ73_RS06985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_116210141.1"
                     /transl_table=11
                     /translation="MRASKPLGRLSAVALASAVALGAAPSPATAAAPATAEVTYTVKER
                     QEALAYWTTARMRQVSENVDLGQTGPLTKEWKGAPVKTVGRLFFVNANGDDTWCTATAV
                     KSGNRSVVLAAGHCVRRGASPANTHMDLVFVPGYSKSAQTPYGVFPVRATVTPASWAQD
                     ARADVAALTVDPVKGRRLTDAVGGQQVAFDREPGGRVTAFGYPATRPQRGQQLLSCTGP
                     ATAAPDDELRMPCDMTGGASGGPWLADFDAKSGLGTLVSVNSHGDALEHSTAMFGPVLG
                     AAARAVHERAQQL"
     gene            complement(13737..14690)
                     /locus_tag="DXZ73_RS06990"
     CDS             complement(13737..14690)
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891804.1"
                     /locus_tag="DXZ73_RS06990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine dehydratase"
                     /protein_id="WP_116210142.1"
                     /sec_met_domain="PALP (E-value: 1.7e-63, bitscore: 213.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRLTYDDIRQATKRATGHVRPVTLAPADPAGAYELWSAMEFMQH
                     TGSFKARGAHNFLAAHREAGTLPATGVTIASGGNAGLACAWAARRQGVRATVFLPATAP
                     HVKVARLRGYGADVRLVGTEYAEALAACEEFAAATGALASHAYDHPLIAAGAGTLLEEI
                     VERVPGLDTVVVAVGGGGLFAGVATAARHHGVRTVAVEPENCRALHAALEAGRVTEVPV
                     DSVAADALGARRVSGTALAAAQDDGVTSVLVPDAAIVAARRSLWDDRRLAVEHAAATAL
                     AALSGPAPAYAPAGGEKVAVVLCGANTDPGDLVDPR"
     misc_feature    complement(14749..14765)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.55"
                     /tool="antismash"
     misc_feature    complement(14751..14763)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.73"
                     /tool="antismash"
     misc_feature    14753..14763
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            14766..15401
                     /locus_tag="DXZ73_RS06995"
     CDS             14766..15401
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643224.1"
                     /locus_tag="DXZ73_RS06995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_116210143.1"
                     /transl_table=11
                     /translation="MPRRSLSLSLATPDRIARTALAVIDEEGPAALSFRSVADRLGVSH
                     ATVHRRCTDLGGLLDLCTDHLAAGLPDIPPGTPWAEATEARFTALYALLTAHPGLVALR
                     GSRPWLGPQLLARLVEPTLADSIAAGMTPEQAFHAYRRMYLLTLGSAAFVDHRDPKATV
                     TTTRTALAALNPEQFPVLTGHMSVILPAMTDHEVFHGALRQLIAAARP"
     gene            15480..15929
                     /locus_tag="DXZ73_RS07000"
     CDS             15480..15929
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988420.1"
                     /locus_tag="DXZ73_RS07000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_116210144.1"
                     /transl_table=11
                     /translation="MTTARPCSIADALGVVGEKYSLLVLREVFFGVRRFDAIARNTGAP
                     RDILAARLRRLVEAGVLEKVPYHERPARFEYCPTPAGQDLRPVLLMLMRWGDRHLADVP
                     PTVLEHTCGADLDSVVVCRCCGEEVASADLTPRFQVPGWTAEGAA"
     gene            16115..17107
                     /locus_tag="DXZ73_RS07005"
     CDS             16115..17107
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS07005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116210145.1"
                     /transl_table=11
                     /translation="MPLPEQIKPGDVVLTRGTESVSRAICLMDDSEVSHAALAVGEDAL
                     AEVVGEGLRTVTFAQAMDGHDLTVCRTLTAPADTAPVLDVARRYLAGHTSYAHQQIVLL
                     AVLCVTRHIPLPLGGRRLVRTVLDQAAAAVNAMAERGRQPMICSEFVYRCHHEARPRAP
                     YVLRTADDDTHPDGTLLGWARAHPAVPRLPLPTGAAAGRPAPADAEAALAPLVSAYATA
                     LGKADLLARHVPVPAGPSDPSDEELLSSMVAFGTALHRADGQGADGQDGSGAPLPPARA
                     LEKIRAMEAEPNFVTPGDLLRSPSLTDSLRMPAGKRTTGAALKGLLNRR"
     gene            17217..17390
                     /locus_tag="DXZ73_RS37970"
     CDS             17217..17390
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576250.1"
                     /locus_tag="DXZ73_RS37970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_162889876.1"
                     /transl_table=11
                     /translation="MSVFAEAMRQRVREARAALVAARAAADAYGTAVAEGELEDALRMA
                     REHDIDPGDEGA"
     gene            complement(17407..18912)
                     /locus_tag="DXZ73_RS07010"
     CDS             complement(17407..18912)
                     /EC_number="1.6.5.9"
                     /GO_function="GO:0008137 - NADH dehydrogenase (ubiquinone)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010360591.1"
                     /locus_tag="DXZ73_RS07010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADH-quinone oxidoreductase subunit C"
                     /protein_id="WP_116210146.1"
                     /transl_table=11
                     /translation="MPRTVTDIGPDELPERAADLLVDGHRLALVAAHHDGPSAPGGPAV
                     RVVYLFASGPPDTRTELHVRLDPKAPELPTLAHLSFPAGRFEREMRDLHGIVPLDHPLP
                     HRLVRHFHWPRGWYPMHPDAGPPPPFAEQEGPYPFLEVEGEGVYEIPVGPVHAGLIEPG
                     HFRFSVVGETIIKLKARLWFVHKGIEKLMEGRTPDRGLPLAERVSGDTAVGHALAYCLA
                     VEEATGTRVPEDARRARALLLELERLHNHVADLGALCNDVGHGILNARAQHVREQLLRL
                     NQEVTGHRLLRGAVVPGGAALCSVPGTARMRVLGREIGDLVTLALGHTTVRDRFTGTAR
                     LDVAAARDLGCLGYVARASGLSADARTRHPFHDYGPALTVPVHTTGDVLARFLVRAEEI
                     DSSLALVEELNERLITGRWVANLAPGRPGATAAGTGIVEGWRGTITTRVELRGRDHTLT
                     RVKTADPSFFNWPALPVALADTIVPDFPLTNKSFNLSYAGNDL"
     gene            complement(18916..20640)
                     /locus_tag="DXZ73_RS07015"
     CDS             complement(18916..20640)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432780.1"
                     /locus_tag="DXZ73_RS07015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="proton-conducting transporter membrane subunit"
                     /protein_id="WP_116210147.1"
                     /transl_table=11
                     /translation="MTHATTALLLTAPIAVPLATSAAHAATGLRGVRPYRRAHAPRHSA
                     ALAHRPPPPRTPAEPARTTGSTAAAGGPATLTGGPPAAPPGPPPFATDGPPAAPPFATG
                     TDTAARPLGTWLGLVSPATILFCGAALAATVPDRGPVTAYGRLLRADALTVWLLLAVGA
                     VAALACAANPSHLAHERADAGAARRYNLLVHAFLAAMSAAVLAANLGVLWIAIEATTIV
                     TAFLVGHRRTRASVEAAWKYVVICSAGIALAFLGTVLIYYAARQAGISEASALDWPTLA
                     AHADRLDPAVTRLAMSLIVLGFGAKAGLAPLHAWLPDAHSQAPAPVSALMSGVLLSVAF
                     AGLLRYKVIADAALGTGYTRTLLAGAALLTLALAAVLLLAQRDYKRMLAYSSMEHMSLI
                     ALGTAIGTPLAVSAALLHIAGHGLAKTVAFCASGHILRIRRTARIGRVRGLLAEAPALG
                     TTFGLAVVALLGLPPFSLFASELGLARAGFTAGHGKVVAVALVLTLVSFAALVTRTARM
                     VLGPPPEPEAVADGPVRLGAAAAAPLVAGLVAAAALGVATGPLTRLLSAAGEIIGRH"
     gene            complement(20640..21335)
                     /locus_tag="DXZ73_RS07020"
     CDS             complement(20640..21335)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656183.1"
                     /locus_tag="DXZ73_RS07020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_116210148.1"
                     /transl_table=11
                     /translation="MNDSVYTQLLDLACGAFLLAAVVVLWLRQLSSIVQVFALQGVALA
                     AVAGLLGVHEGRWDLLAVAVGIGLLRAGALPHLIRRALAAGTPPPTRHYEEDVSEARET
                     QPLVNVAASLLSAALLTLLAYAVARPLVELDPTPATSALPVGLAVVLIGFFTLVTRRRA
                     LAQVVGFLLLDNGITATAFLAASGVPLIVELGVSFDVLLAVLVLQILTTRMRAAFGGTG
                     IDDLRELRD"
     gene            complement(21347..22300)
                     /locus_tag="DXZ73_RS07025"
     CDS             complement(21347..22300)
                     /EC_number="1.6.5.9"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656184.1"
                     /locus_tag="DXZ73_RS07025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADH-quinone oxidoreductase subunit H"
                     /protein_id="WP_162890095.1"
                     /transl_table=11
                     /translation="MKAIGTAAVTAQVVLVVAGAPLLAGTMRQVRARMEGRAGPGVVQP
                     WRDLRKLLRKEAITPIGTGPAFRVAPLLLVATTAVVAALVPLASTVTPVSGSADLILVV
                     ALLALGTVALALAGLDTGTAFGGMGASREMTVAALVEPTILLAVFALSIPTGSTNLSAI
                     VSGGIHDPVRLASPAGLLATAALAVAVLAETGRLPVDNPSTHLELTMVHEAMVLEYAGP
                     DLALVELGAQMRLAVLLGLLASLSAPWGIATTASPAALALALVLLTAKVALLGSALAAA
                     EVFWAKLRLFRVPELLAGSFLLALLAVTASYFLTGE"
ORIGIN
        1 atggccgtcg cctccctgga ctcagaggtt tctgacctac ttccagcgtc gcgcggagga
       61 tcatgaggcg cgacttgagg gcggggcgta cctgggcgac tggcgcggcg ctcggatcgg
      121 tcttcctgct ggtcagaccg tggataccaa gttgacagaa ctcctcagtt cggtgcgctg
      181 gtccatgact cccagtatgc gggggtctcc gcaggcccag ggtggtactg ccagtggtag
      241 gcacagcgaa cgtaggttaa gcggagtgct ggttagcgga tccggacggt cgcatgctcg
      301 tgagcatgaa gcacaccact gttcccgcat acgccgcacc cgcgccgaag gccccgctgg
      361 agcgcaccac gatcgagcgc cgcgagccgg gcgagcacga cgtcctcatc gagatcaagt
      421 acgcgggcat ctgccactcc gacatccaca cggcgcgtgc cgagtggggc gagggcacct
      481 tcccggtcgt ccccggccac gagatcgcgg gtgtggtgac cgcggtcggt acgggtgtca
      541 cgaagtacgc gctcggcgac cgcgtgggcg tcggctgttt cgtggactcc tgccgcgagt
      601 gcgacaactg cgaggccggc ctccagcagt actgcaccgg cgcgtccggc atggtcggca
      661 cgtacggggc gacgggccgt gacggcgaga tcacgtacgg cggctactcc acgcacatcg
      721 tcgtcgacga gaactacgtg ctgcgcatcc ccgacagcat cccgctggac gccgcggcgc
      781 cgctgctgtg cgccgggatc accctctact cgccgctcgc ccactggcag gccgggcccg
      841 gcaagaaggt cgccgtcgtg ggtctgggcg gcctcggcca catgggcgtg aagatcgccc
      901 acgcgatggg cgcggaggtc accgtgctca gccagtcgct gcgcaagaag gacgacggcg
      961 agcggctggg tgccgaccac ttccacgcga cgtccgaccc ggccaccttc acgtcgctgg
     1021 cgggcacctt cgacctgatc gtcaacacgg tctccgccga tctcgacctc ggcgcctatc
     1081 tctccctgct gaagaccgac ggcacgctgg tgcaggtggg cgccccggag aagccgctgc
     1141 cgctggccgc gttcgccctc atccagggcc gcaggtccct cgccggttcg atgatcggcg
     1201 gcatcccgga gacccaggag atgctggact tctgcggtga gcacggcctg ggcgccgaca
     1261 tcgaggtgat cggcgccgac cggatcaacg aggcgtacga gcgggtgctc gccagtgacg
     1321 tccggtaccg cttcgtgatc gacgccgcga cgatctgagg cgcgtcctcg gcgggccccc
     1381 ggccgccctc gcgcgactcc gcgcgccggg ggcgcggtgc ggccgggcac cgcgcgattg
     1441 tcagtggccg gtgccagact gaaaggcggc cgggggacga gcgttctccg cgtccgcggc
     1501 gaccgggccc cggcgacgat ccgtcgaagg agcacaccac catgctcacc actgactttg
     1561 tgaccggcgc gcccaactgg ctcgatctcg gcagcccgga caccgcggcg tccgccgcct
     1621 tctacagccc ggtgttcggc tgggacttcg agtcggcggg gccggaggcc gggggttacg
     1681 gcttcttcca gaaggacggc aggaccgtcg cggccctcgg accccttacc gaggagggcg
     1741 cgtcaccggc ctggaccgtg tatttccgca cccccgacgc ggacgccacc gccaaggccg
     1801 tcgagcaggg cggcggcacg gtgcgcgtcg cgccgttcga cgtgatggac gcggggcgga
     1861 tggcctgtct caccgacccg tccggtgccg agttctccgt gtggcagccc gccgcggtca
     1921 agggcctgga ggccgcctcg gagagcaaca ccctgtgctg ggcggagctg cactccgccg
     1981 acccgacggc cgccttctcc ttctaccgct cgctgttcgg gtggcggagc caggagatgg
     2041 aggccggggg gatggcgtac accgtgctct ccacggcgga gggcgaccag caggacgcgt
     2101 ccttcggtgg cctcgtggcc gccgatgagg acagcgagac gcgctggatc ccgtatttct
     2161 cggccgacga cgccgacgcg atcgtcacca gggtgcagga gaacggcggc tcggtcctga
     2221 tgcccgcggc ggatgtgccg gacgtcggcc ggatcgcctg gctcgcggac ccgttcgggg
     2281 cgccgttcgc cgtcatcaag cccatcccgc ccgcggcctg acggcggctg ccggtgtgtg
     2341 gtccccgggc ggggaccaca caccggcagg gcgtcagctc tcctccgcct cgccctcggc
     2401 cgcggcctcg ggtgcggcgg cgccctcctc ggcctcctct tcttcctcgg ccggctcctc
     2461 ggcctgcgcc gcgaccacct ggaggacggc gtcctccccg tcgatggcca gggaggtgcc
     2521 gcgtggcagc gggatgtcct tggcgcggat ggtgtgcccg gcttccatgc cctcgatgga
     2581 gatggtgaac ccttcgggga tgtgggtggc ctcggcctcc accggcaggg cgttgaggat
     2641 gtgttcgagg aggttgccgc cgggggcgag ctcgccctcg gtgtgcaccg gcacctcgac
     2701 agtgaccttc tcgcccttct tcacggtgag gaggtcgacg tggacgagga agccacggag
     2761 cgcctcgcgc tgcacggcct tggggatgac cagttccttc ttgccctcga cgtccaggtt
     2821 gatcagcacg ttcggcgtct tcagggccat catcagcgcg tggccgtcga tcgccacgtg
     2881 tttggggtcg gcgccgtgac cgtagacgac cgccgggacc tttttgtcgc ggcggatgcg
     2941 acgggcatag cccttgccga attcggtacg cagctcggcg gtcagcttta cctcggccat
     3001 gactgcactc ctcgtgttca gactgtcggt acctgtcgag tggccgtcac ccgggccacg
     3061 acagacctgg tacgaggggt gcgccgatga cggatcgccg caccccatga gtacggcctc
     3121 cctcgccgag caactccggg agtttatccg gcgcgaggtg gacgactctc cgccactgct
     3181 ccgtacggcc cagcacccgc cccgatcgtg cgggtttccc gccgcggccg ttaccccggt
     3241 gccgccccgt ggggcggagc cccgtcgcgg aggttcagcg ggcgcagcac gcgcgcgtcc
     3301 ggtaaggatt ccgcgcaggg cgcgcacagc gcggtcaggc accacacccg ccccgcctcg
     3361 ctgtgcgtga tcacccggtg gacggcctcg gcccggcacg cgcaccgcgc ccccgccggt
     3421 gccgcctcca accgccgtcc gtgccaggcg agatgccccg cagcggccgt ccgcgcggcc
     3481 gagggcgcgg gcagcggcac ggggtccggc cggcagcccg gctcggagca gtgcagttcc
     3541 atgcgccccg gtgccggata gcgatcggaa acaatggtca ctgtccagag gtgcaccaca
     3601 actcgctcct gaggtcgggg acacacggcc accactccag ggtgcggtgc cgcgtgcata
     3661 tacggaatcc acccgccgcc acggaagtga tcgggcagac tttgcgggca ccgtgcagac
     3721 accgtcgcgc agacgagggg aagtcccatg agcggaatgc gaagattcag ccgcagaggc
     3781 atgttacggg cgggcctggg ggccggtgcc accgcactgg tggcacagct gacaccccga
     3841 ctccccggcc cgttcgagtt gtacgagagc cccgcctggg cggcggccgc ggcccgtcag
     3901 ggggcgtccg gggcctttcc ggagtggagc cgcttcgcgc ggctggcgga cggcaccttc
     3961 gacgaggacg ccgaccccac ccgtgacatg aagcccgtga tcgcggcgct gaagtcgcag
     4021 aacgtcaatg tcatcgagct cgacaccatc atgtcgaact ggatcaccga ggcggacttc
     4081 acccagcacc tcgggaagat caagagcttt gtggagctgg cgcacggtgc cgggatccgc
     4141 gtggtcatgt actacccctc gctggaggtc atcagcgtcg gcggcgagaa cggccgttcg
     4201 ttctacaaga acggtgacgg caagtcctgg gtgcagcgcg gcctcgacgg caagcccaat
     4261 gtcttctacg gcagcctggt ggtctgggtc gacccgggcg acgagagctg ctgggtcagc
     4321 cccaactccc cctggcggga cttctacctg ggccggatca aggcgctcgc ggggacgggt
     4381 ctggacgcgg tgtggccgga cgtcccgatc tacttcgacg gcgcgatcag ctggtgcgac
     4441 acctcgacgt gggcggcgga cgcgttccgc gccgacaccg gcctcgcgct gcccaccaag
     4501 gccgacttcg gcagcctccc gttccgccgc tacgtcgagt ggcggcaccg caatctcctg
     4561 cagtggcagc tggacatcgc cgccgccggg cggtccgtca acccggatct ggtgacgttc
     4621 gtcgagaccg tgagcatgga ctaccagtac gccacgctgg tcggcctcga cggggcctac
     4681 ctgcggaagg cggagggggt cagccatgtg tgggaggtgg acatcctcgg caactacgac
     4741 gggatgcgcc acgcgaccgc caccgactgg acgtgcctga tctcgatgta caaatacgcc
     4801 cgcgccgcca gcggcaccaa gccggcctgg gcgttctcct acggctggca ggccgacgac
     4861 gcgtcgctgg tgatggccga actgctggcc gcgggctgca atccgtacga ggtgaagagc
     4921 ccgttcaaga acgacaccac cgacaaggcg atgcgcaccc ggatgtacgc cttcgtggcc
     4981 gccaaccagg agaagctgta caactccgct tccacggcgg ccgtcggtgt ctaccactcc
     5041 tccgcctcgc gggacttcgt cagccccgcc gtcggcacgg ggatgtatgt gaacacccgg
     5101 aagccgtccg gggtcaagga gtggtgggcc tccggcagcg cggaggagag ctgcaccaat
     5161 cagcagtggc tgggcgagtt ccgcggcacg gtgaaggcgc tggtgttcgc gcacatcccc
     5221 ttcgacacgg tgaccagtcc gggcctcgcc gcggccgatc tggcgggcct gcgcgtgctg
     5281 atgctgccga acctccaggc cgtgtcggac gccgaggcgg gcgtactgcg cgacttcgtg
     5341 gcgggcggcg gcacagtggt gatcaccggt ccggcaccca gcgccctcga cgagttcggc
     5401 acggcgcgga gcgagtacgc cctcgccgac gtgctcggct tccgcaaggc ggatccgctg
     5461 cccacgagca agcagaaccg tttcggttcg ggcacctgcc ggtatgtgca gaagctcgtc
     5521 ggcaagagct atctggcctc gaccgaccag gcgagcgccg atcagctgct cgggccggtc
     5581 acggccgcgg cgccaccgga ggtgacgctc tccggtgacc cgcggatcca tctggaggtg
     5641 cgcaggctcg gcgccgacac cgtcgtccag ctggtgaact tcaccggctt cggcgacacc
     5701 ccggccgcgt tcaagacggc gcccaccagt tgcacggtct cgctcgcgct ccccgcgggt
     5761 cggcgggtgc tggccgccac ggtgagctcg ccggacggcc cctcccccgc gccgcagccg
     5821 gtcgactggc ggctcgtcgg ggccacggcg aacgtgacgc tgacggtgaa tcagtacgcg
     5881 ctgctgaccg tcaccaccgg ctgagcctca ccctcgcctc acggtttcgc cggcccgggg
     5941 acggggatcc gccacagcga cgtgggccgg tcctcgtccc ccgagcgggc ctcgaaggcg
     6001 atccagcgcc cgtcgggcga ccagctgggc gcgccgtcgt agccaccgcc gttcctcgtc
     6061 acccgggtgg gcttgccccc gtccgccggg atcacgaaga tctgcggtgt gtcgagcccg
     6121 cccgcggtgg aggagaagac cacggaccgg ccgtcgggcg accagctggg gtcggtgtgt
     6181 tcgccggggc cgtcggtgag ccggcgcagc ccggtgccgt cggcgttcat cacatacagc
     6241 gcccagtcct cgctgtccgc cgcacgccgc tggaagacca gccggtcgcc cttcggcgac
     6301 cagttgggct ggcggttgtc cgtacgggtg gcggggccgt ccaggaggcg ggtgggttcg
     6361 ctgccgtcgc gccggacctt ccagagggag ccgagggccg aggggtcgtc gtcgctctcc
     6421 cttccgccgt tctccttctc gacgctctcc tggaagacga tccaggagcc gtccggcgag
     6481 aagctgggct ccaaatagcc ggtgtcaccc cggtgttcgg tcacccgggt gggccggtgg
     6541 ccgcccgggg gcagcaccca cacctcgtcc cggcccgcgc ggtcggaggc gaaggcgacc
     6601 ccggcggagg ggtgccagct ggagcccggg aggttgacgg cggcccggtc gctctcgtcg
     6661 agcagcgtcc cgggccgggc cgacgcgccg ttcccgatcg gcagcacccg cagggcggcg
     6721 gccccttcgt tgtaaccgtc gtggaagagg gtgaagagga cggacgtccc gtcgggcgag
     6781 aacgcgggat tctgggcgct ggcccgcccc tgcccccggt agagcagctg ggcgccgtca
     6841 ccgcgggccg tacggccgtc ggacggagcg ggcgggcgcg gcgacccccc gccggaaccg
     6901 cacgcggtga gcacgagagc ggccaggaac gcgacaactg ccaggcgact gcgcaccgca
     6961 ccgaccctag tgggtggctc gcactggtgg gcgggaatcg gcgttccggc ggaccgcgcc
     7021 ccagggcacg cccctcttcg cgcgcacgga ccgtacgccg cacctccaca aacaccgtcg
     7081 ccatgtgtaa tcacctggac accctgggta ggctcccggg cgtcgcgcca ccccgccgcc
     7141 cctcaactcc catcgcaccc agggtcgtcc agcgcaagga acgagccacg ctcctcgaca
     7201 ccgagagcct gccggcggcc cctgtccacc cttgtccgag gaggctcgcc gtgaccaccg
     7261 accggaccgc cgccccgccc ggggtcttca ccccggcctt cttccaggac gcccaccccg
     7321 tcttcgacac cctgcgctcc cgtgcgcccg ccaccctggt gacgggggtg agcggcaccc
     7381 gcctgtggct gatcccccgt tacgaggagg cccgcagact gctgtcctcc ccctcggtcc
     7441 gcaaggacga ctggaagcgc cccgacctga gggagcagca cctcgtccgg accgagcggc
     7501 gccgcgagat gagcacccgg atccgggcca atatgatcaa caccgatccg ccggagcacc
     7561 agcggctgcg ccagggcacc cagcaggcgc tcagccgggg ccggatcgag gccctgcgcc
     7621 cgcgcatcga cctcttcgcg gacgagacgc tcggcgagct cgacgccgcc ggggacgtgg
     7681 gaccggtcga gttccgcgcc cggatcgcct accccttcac cgtcgccgtg gtctccgagc
     7741 tcctgggcct gcgcgaggac gaacagcccg gtttcccggc ctggttcgac accctgatgt
     7801 gccggcgcgg caccgagaac gcacggcaga cctcgctgat cctcgccgac ttcagcgagc
     7861 ggctcgacca ccgcaggcgc gcgcaccccg cccggggcct gctgtccacg ctgggctcga
     7921 agccggacag gcggcggccg ctcagccgca ccgagctcgc ctcgaccgcg ttcctgctgc
     7981 tgatcgcggg catcgagacg gccaacgcca tctccaacgg gatgttcgcg ctgctgagcc
     8041 accccgagca gtacgaggcg ctgcgcgcgg accggtcgct gctgaccggt gccatcgagg
     8101 agtgcctgcg ccacgacggg ccgttccgcg cggtcggccc gcgctacacc gccgagcgcg
     8161 tggatctgga ggacggggtg tccatccccg ccggggagtt cctgctgatc gccgtctccg
     8221 cggccaaccg cgatccgcgc cgcttccccg atccgcaccg cttcgacatc acccgcaccg
     8281 atcatcagca cctggccatg gggcacggcg cgcaccgctg cgtgggggcg ctgctcgcct
     8341 atacggagat ggagatcctc ttcgacaagc tgctggaccg gtttccgcgg ttgcggctcg
     8401 ccgtgccggt gccggagatc cgccgccggc cgagcatgac gatgaactgg ctccaggatc
     8461 tgccggttct gctgcggtga cggggcgggg ccggggagag aggtgtccgg cggggctacg
     8521 ccagcagcaa tgcccggtcc cagaccggct ccacatccgt cgccgccgcg agcagcgcga
     8581 gcaccacccc ggcggcaccg tccaaaaacc ccggcccggc agccggaagc gccgcccggc
     8641 accccagaag ccgccccgcc ggccccgccg ccgcacggcg cagctccgcg tcccccgtgt
     8701 cttgcacaaa gcgcacggtg acctggagca acccggccgt cccatgacac agccccgccg
     8761 cgcactcggc gtccggccgc gccgcgaggc gccggtgcac ggccctcagg gcccgtacgg
     8821 cgaggtcgca cagccgcgcg tcctggagcg ccgtccccgc cagccacagc gcccgtgcga
     8881 tgccggggcc tccgtagcac catgtcgccg gggcacgccc ctccgcggcg gggcgtccgt
     8941 ccggccccac ccggcccggc cagtgcggcc cccactcgtc atcggtccgg ccggaggcca
     9001 gccgggcggc gagtcgctcg acggcctccc gctgaccggg cacggtgacg gcggcggaga
     9061 cggcggacga cagcagggcg agtggcccgg agattccgtg cgccataccg aagttgagca
     9121 ctccgcccgg gaacagggct cgcgtggcgg cgtcgccgat gtgctcggcg ggggtcagac
     9181 agtgcggggt gccgtcccgc tcgccgctca gcgccaccag cccggtgagc acggcgtgca
     9241 gtgcggcgcg ggaggccggt tcgtggtgcc ggcacaggag gtacgctccg gtgccggtga
     9301 gtccggagat caggtcgaag acgcggacgg gcacgccgtg gggtgcgtca ccaagtgcct
     9361 tgatccgtaa ggatgtcgac ctcagcaccg cgtcgtgcac ctcggggagc gggtccgctc
     9421 cgggcggcgt gagcgaccgg gcggcgaagg cgatgccgcc gagcccgccg tggagccccg
     9481 ggaacgccgg cccctcccgc tcggcgccgc ggacagccgc ggcgaggtag ccgtcggcca
     9541 tggcgcccca tccccgcccc ggcaggcagc ggtccaactg gtggtacgcc agggcgagtc
     9601 cgggcccgcc ggcggcgagg tcggggcgca ccctgcgggg cacggggcgc ggccgtccgg
     9661 cgagggcggt ggcgaggtcg agggccgcgg cggccgtcga cccgtgcagc accgccgccc
     9721 agtggccgtc ggccacggct cctcctctgc tcctctgctc ctctgtcgga tcggttggct
     9781 ccgggtggcc gcgcggccac ccggaaccgg tgggcgcggt caggacgggc gacagcgcgg
     9841 cggatccgtg cactggccgc tggtgtggtc ggtgtcgcag cacatcatcg gctccagctc
     9901 gcgctcgtcc gtctccggca gctcctgaag ctgaagtacc tcgttctcca tggctctcac
     9961 ctccttccgg ggctctttcc gctcgcggcg gagcggtccg tcagtggccg cagtcgacca
    10021 gccaggaccg ggggccgccg tgcttgaggc gcaggaggaa gtcgaggacg ccggacatcc
    10081 cgacgttgta gctcgcgcag acctcgcgca gggtgtcgtc ggggacgacc agccggccgt
    10141 cgcgttccac ggccctcgga tacaggcagg tcgcggcctc ctccgcccag gtgcggtagc
    10201 gctcctcccc cgtcgcctcg gcgaggtcga gcagcagctc ggcgttgccc gcgacgccgt
    10261 ggcaggtgcc ggggccgacc cgccagcggt cgcggtgggc cgcgacggcc gcgagctcgg
    10321 cgtacgtacg gaagcgcgcc tcccccgtcg cctgccacag ccggaccagg aacgtcccca
    10381 cgcccgaggt cccgttgcac cagaagtcga gaccggtgcg ctcggcgcgg cccggtccct
    10441 tgggccagtg cgcggcgtct ccgtggcgtt cggcgacggc gcacagggcg tggccgccgc
    10501 cggccgcgat gtcgacgagt tcggggcggg ccaggtcccg gccggcggcg agcaggaagg
    10561 tggcgttccc ggcgacgccg tgtccgaagc cgtagaacgc ggaaccggcg agttcggtgc
    10621 ggtgttcggg gcctgcggcc cagtccaccc cgcggtccgc gtgcgcggtc agccggagca
    10681 gcccgtccgc gcactccgag gcgcgttccg cgaaccgccg gtccccggtc gtgtgccaca
    10741 ggtgcagctg tgccaggccc gcgcccgcga ggccgtggca gatgtccggg ttgtgccagt
    10801 cgagggggat ccgcagggcg tactcccgcg cgcgctcggc caggagggtg tcgcccaggg
    10861 tgcgggcggc gccgtggagg gcccatacgg cgccggagcg gccgaagtag aggccgggca
    10921 ggatccggct gggcagggtg agccgttcgt cgagccactg cgccgtggtg cgcagcaggg
    10981 gttcggcggg catctcgccg gtgcggacgg cccggtcgag cacggccagc acaccggcgg
    11041 cgcccagttg gacgttgcag gggtcgccgt acggcagggc gcgcggccct ggccagaggt
    11101 actcggcgga gggttccacg gtggccgcca ggtgggcgag gccgtcgccg atgagccggt
    11161 cggtccgacg gggcgtcagc gcgggtccgg cggtcacggg ccgtacgacg gggtcggcgc
    11221 gcaggaaggc cgcggccttc tccaggggcc agcgggaggg gccgtccgcg gtgaggccga
    11281 ggacgagggg ggcgagcgcc cggagtgcgg ggaaggcggg ggcggccgcg tcgacgaggg
    11341 ccgcgaggcg gtcgccggcg gtgcggccgg gtggtgtgtc gggggcgagc acggggctga
    11401 tgccggtggt ggcgtggagc agggtggcgc ccaggctgta gcagtccgct tcggggccgg
    11461 gcgcgggcgg cggggtgtcg ctgtcgcggc cgggtccgtc gaggtattcg ggtgcggtga
    11521 agccgtgggt gcccgcgacg tacgcggtgg cgtcggcgcg gaccgcgcat tccaggtcga
    11581 ccaggacggg ggtgccgtcg ggtccgatga cgacgttgcc cggtttgaag tcgcggagga
    11641 cgaagcccgc tgtgtgcacc tcgcccatca ggcgggtgag ttcgcgcgcg agctcccatg
    11701 ccgtgggcac cggcaggcgg ccgctgtcgc gccacgcgtg ctccgcggcc cactgctgga
    11761 ggctcttgcc gtcgatcagg tcctcgacga ggaagacgtg cccggccgcc tcgaacacct
    11821 cgcgcacggc cggggtgacg cggtgcgggg cgagccgggc caggacggtg gcctcgtatc
    11881 tcagccagtc ccgcgcgtcc ttgccgtcga ggccggcgcc gatgtgcggg cgcgcctcct
    11941 tgagcaggac gtcctcaccg gtgcgccggt cgtgggcgcg gtagacaccg ccgcggttgg
    12001 agtgccggac ggcttccctg acgaggtagc ggccgacgag caggacgggg ccgccgcgcg
    12061 ggcgtccggg cgcgggcggg tcgaagggtg atgcggccca gggcggtggt tcgaaccagg
    12121 ggttgcgcgt gtcggtgacg aaggtgccgt cgggggcctg cagccgccct tcgtagaagc
    12181 cctcgtcgcc cagctcgtgg ggccgggcga agcagccgaa gcggtagtgg acgaggctgt
    12241 ccggccggta gcgccggtcc gaaaggatcg tgggtccggc gaggccgagg gtggcacggt
    12301 ggagttcctc ggcgagcacg cgcagttggt cgtcgtcggc ggggtaggcg gtgaggaact
    12361 tgcccgattg cgcccgggag gcgcggacgg aggtgagttc ggcggcgacc cggggcgaga
    12421 cggcgaactt gaaggcgcat ccgtgcgcca ccaggaccgg agccgcgcgt tccaggacgt
    12481 ggggtgcgga tgcgggcgtc gccgacaggt gcagcttcca gccctgcggg cggcggtcgt
    12541 ggcgcggtgg ggtgaccatg caccaggtcg cgccgtcccg gagggtccag tcggggccct
    12601 tgtcccgcag ggcccgcagg gtgatcgact gatagctcag tgccacggca ccgatgatga
    12661 caccgccggg ggccgttagc gagaggctgt cccggccggt tggcaggcag gcgcgcgtcc
    12721 cgtccggccc ggtgccgtac gccggggaac cccatcggct gacggaccgt ctcccagcgc
    12781 gacagacccg atcattccgc tttattccga ggagaaccat gcgcgcttcg aaaccgctcg
    12841 ggcggctgtc cgccgtcgcc ctcgcctccg ccgtcgccct gggcgcggca ccgtccccgg
    12901 cgactgcggc cgcaccggcc acggccgagg tgacgtacac ggtgaaggag cgtcaggagg
    12961 cgctggccta ctggacgacc gcgcggatgc ggcaagtcag cgagaacgtg gacctggggc
    13021 agaccgggcc gctgaccaag gagtggaagg gcgcgccggt gaagacggtc ggccgcctct
    13081 tcttcgtcaa cgccaatggt gacgacacct ggtgcacggc cacggcggtc aagagcggca
    13141 accgctcggt cgtgctggcc gccggtcact gcgtacggcg cggcgcctcc cccgccaaca
    13201 cccatatgga cctggtcttc gtgcccggct actcgaagag cgcgcagacg ccctacggcg
    13261 tcttccccgt acgggccacg gtcacccccg cctcatgggc gcaggacgcg cgcgcggacg
    13321 tcgcggcgct gaccgtcgac ccggtcaagg gcaggcggct gacggatgcg gtgggcggtc
    13381 agcaggtggc cttcgaccgt gagccgggcg gccgggtgac cgcgttcggc tatccggcga
    13441 cgcgcccgca gcgtggccag cagttgctct cctgtacggg cccggccact gccgccccgg
    13501 atgacgagct gcggatgccc tgcgacatga cgggcggggc gagcggcggc ccgtggctgg
    13561 cggacttcga cgcgaagtcg ggcctgggca cgctggtttc ggtcaacagc cacggtgacg
    13621 cgctggagca cagcaccgcc atgttcggcc ccgtgctggg tgcggcggct cgcgcggtcc
    13681 acgagcgggc gcagcagctc tgacgctcgc tcagcgcaag gtcgcccgga acccgtctac
    13741 cgggggtcca ccaggtcgcc ggggtccgtg ttcgccccgc agagcaccac cgcgaccttc
    13801 tcccccccgg ccggtgcgta ggcgggcgcg gggcccgaga gcgccgcgag cgccgtcgcc
    13861 gccgcgtgtt cgaccgcgag gcggcggtcg tcccacaggg accggcgcgc ggcgacgatc
    13921 gcggcgtccg gcaccaggac cgaggtgacg ccgtcgtcct gcgcggcggc gagtgccgtc
    13981 ccggagacgc gccgggcgcc gagggcgtcc gcggcgacgg agtcgaccgg cacttcggtg
    14041 acccgcccgg cctccagggc ggcgtgcagg gcgcggcagt tctcgggctc gacggcgacg
    14101 gtccgcaccc cgtggtgccg ggcggccgtg gcgaccccgg cgaacagccc gccgccgccc
    14161 accgcgacga cgacggtgtc gaggccgggc acccgctcca cgatctcctc cagcagggtg
    14221 ccggccccgg cggcgatcag cggatggtcg taggcgtggc tcgcgagggc ccccgtggcg
    14281 gccgcgaact cctcgcaggc ggccagggct tcggcgtatt cggtgccgac gagccggacg
    14341 tccgcgccgt agccgcggag cctggcgacc ttgacgtgcg gggcggtggc ggggaggaag
    14401 accgtcgccc ggacgccctg ccgccgggcg gcccaggcgc aggccagccc ggcgttgccg
    14461 ccggaggcga tggtgacgcc cgtggcgggc agggtgccgg cctcgcggtg ggcggcgagg
    14521 aagttgtgcg cgccgcgcgc cttgaaggac ccggtgtgct gcatgaactc catggccgac
    14581 cacagctcgt acgccccggc cgggtccgcc ggggcgaggg tgacgggccg gacgtgtccg
    14641 gtggcccgct tggtcgcctg ccggatgtcg tcgtaggtga ggcggtgcac gggaaggtcc
    14701 cccttcaatc gcgtggcggc catcgggccg atcgctgtgt tacagcgtac gttacagtgt
    14761 cacacatgcc gagacgttcc ctttccctga gcctggccac ccccgaccgc atcgcccgca
    14821 ccgccctcgc ggtcatcgac gaggaaggcc ccgcggccct gagcttccgt tcggtcgccg
    14881 accggctggg cgtctcccac gcgaccgtcc accgccgctg cacggatctg ggcgggctgc
    14941 tcgacctgtg caccgaccac ctcgccgccg ggctgccgga catccccccg ggcacaccgt
    15001 gggccgaggc caccgaggcg cgcttcaccg cgctctacgc gctgctgacc gcccaccccg
    15061 ggctggtcgc gctgcgcggc tcccggccct ggctcgggcc ccagctgctc gcccggctgg
    15121 tcgagcccac gctcgccgac agcatcgccg ccggaatgac cccggagcag gcgttccacg
    15181 cctaccggcg gatgtatctg ctcacgctcg gcagcgcggc cttcgtcgac caccgggacc
    15241 ccaaggccac cgtcaccacc acgcgcaccg ccctggccgc gctcaacccg gagcaattcc
    15301 cggtcctgac cggccacatg agcgtcatcc tgcccgccat gaccgatcac gaggtcttcc
    15361 acggcgccct gcgccagctc atcgccgccg cccgcccctg agagcggtgg cagaggccgg
    15421 atcggccgtg ttccacgcag ggttggggaa gcaaatccgg ctgctttacg atgaggggca
    15481 tgacgacagc gcgcccatgt tcgatcgccg acgcactcgg cgtggtcggc gagaagtact
    15541 ccctgctggt gctgcgcgag gtcttcttcg gcgtccggcg cttcgacgcg atcgcccgca
    15601 acaccggagc ccctcgtgac atcctcgccg cgcggctgcg ccgcctggtg gaggcggggg
    15661 tcctggagaa ggttccctac cacgagcgcc ccgcccgctt cgagtactgc cccacccccg
    15721 ccgggcagga tctgcgcccc gtgctcctga tgctgatgcg ctggggcgac cgccacctcg
    15781 cggacgtgcc gccgaccgtc ctggagcaca cctgcggtgc cgacctcgac tccgtcgtcg
    15841 tctgccgctg ctgcggcgag gaggtcgcga gcgcggacct cacgccccgc ttccaggtcc
    15901 cggggtggac ggccgagggc gcggcctgat cgccggccgg ccgcccggcg gtcgtcgagg
    15961 cgcacccccc ggcaggggtc gccgacgtcg tggagcggcc cccgcgctcg ggggcgttcc
    16021 cctatccggt gcattgtctg cgaccgctcg cttgccgtac ccgtccaggg ggcatgacag
    16081 gggcccgccc ctcccctcca gacgggaacg ccgcatgcct cttccggaac agatcaagcc
    16141 cggggacgtc gtcctgaccc gtgggaccga gtccgtctcc cgcgcgatct gcctcatgga
    16201 cgactccgag gtcagccacg ccgcgctcgc cgtcggcgag gacgcgctgg ccgaggtcgt
    16261 cggcgagggg ctgcgcaccg tcacgttcgc ccaggccatg gacggccacg acctgacggt
    16321 ctgccgaacc ctgaccgctc cggcggacac ggcccccgtc ctcgacgtcg cgcgccgcta
    16381 tctggcgggt cacacctctt acgcgcacca gcagatcgtg ctgctggccg tcctgtgcgt
    16441 cacccgccac attccgctgc cgctgggggg ccgccggctc gtgcggaccg tcctggacca
    16501 ggcggcggca gcggtgaacg cgatggccga acgcggccgg cagcccatga tctgctccga
    16561 gttcgtctac cgctgccacc acgaggcccg gccccgcgcc ccctacgtcc tgaggacggc
    16621 cgacgacgac acgcaccccg acggcaccct cctgggctgg gcccgcgccc acccggccgt
    16681 cccgcgcctg ccgctgccca ccggggccgc ggccggacgg ccggccccgg cggacgccga
    16741 ggccgcgctc gccccgctgg tctccgccta cgccacggcc ctcggcaagg ccgatctcct
    16801 ggcgcggcac gtccccgtcc cggccggtcc gtccgatccg agcgacgagg aactgctgtc
    16861 gtccatggtc gccttcggca ccgccctgca ccgcgccgac ggtcagggcg ccgacggtca
    16921 ggacggctcc ggcgcgcccc tcccgcccgc gcgggccctg gagaagatca gggccatgga
    16981 ggccgagccg aacttcgtca cccccggcga cctgctgcgc agcccctcgc tgaccgattc
    17041 gctccggatg cccgccggga agaggaccac gggtgcggcg ctcaagggcc tgctgaaccg
    17101 ccggtagccg ccgccgggag cgccgcgcac cgggacagcc gagaaggggc aggggcaaag
    17161 ccgtggattg agcctagact tgaggaatcc ttcccaccgt tccccttggg ggcgccgtga
    17221 gcgtgttcgc cgaagcgatg cggcagcggg tccgcgaagc ccgcgccgcg ctggtggcag
    17281 cgcgggcggc ggccgatgcc tatgggaccg ccgtggcgga gggggagttg gaggacgcgc
    17341 tgcggatggc ccgtgagcac gacatcgacc ccggtgacga gggagcctga tccccctctc
    17401 cgggcctcac aggtcgttgc ccgcgtagga caggttgaag ctcttgttgg tcagcgggaa
    17461 gtccgggacg atcgtgtcgg ccagcgcgac cggcagcgcc ggccagttga agaaggacgg
    17521 gtcggccgtc ttcacccggg tcagcgtgtg gtcccggccg cgcagctcga cgcgcgtcgt
    17581 gatcgtgccg cgccagccct cgacgatgcc ggtgcccgcg gcggtggctc cgggcctgcc
    17641 gggcgcgagg ttcgccaccc agcggccggt gatgagccgc tcgttgagtt cctcgacgag
    17701 ggcgagggag gagtcgatct cctcggcccg cacgagaaag cgggccagga cgtccccggt
    17761 ggtgtggacg ggcacggtga gcgccggccc gtagtcgtgg aacgggtggc gggtcctggc
    17821 gtcggcggac agtccgctgg cccgcgcgac atagccgagg cagcccaggt cgcgggcggc
    17881 ggccacgtcg agccgggcgg tgccggtgaa gcggtcgcgg acggtggtgt gcccgagcgc
    17941 gagggtgacg aggtcaccga tctcccggcc gagcacccgc atccgcgccg tgcctggcac
    18001 cgagcagagg gccgcgccgc ccgggacgac ggcgccgcgc agcagccggt ggccggtgac
    18061 ctcctggttc aggcgcagca gctgttcgcg gacgtgctgg gcgcgggcgt tgaggatgcc
    18121 gtggccgacg tcgttgcaca gggcgccgag gtcggcgacg tggttgtgga ggcgttccag
    18181 ttcgaggagc agcgcgcggg cgcgccgggc gtcctcaggc acccgggtgc cggtggcctc
    18241 ctcgacggcc aggcagtagg cgagggcgtg gccgacggcg gtgtcgccgc tgacgcgctc
    18301 cgcgagcggc agtccgcggt cgggggtgcg gccctccatg agcttctcga tgcccttgtg
    18361 gacgaaccac aggcgggcct tgagcttgat gatggtctcg ccgacgacgg agaagcggaa
    18421 gtgcccgggt tcgatgagcc cggcgtgcac cggcccgacg gggatctcgt agaccccttc
    18481 gccctcgacc tccaggaagg ggtacgggcc ctcctgctcg gcgaagggcg gcggggggcc
    18541 cgcgtcgggg tgcatcgggt accagccgcg gggccagtgg aagtggcgga cgaggcggtg
    18601 gggcaggggg tggtcgaggg gcacgatgcc gtgcaggtcg cgcatctccc gctcgaaccg
    18661 cccggcgggg aaggacagat gggccagggt gggcagttcc ggggccttcg ggtcgaggcg
    18721 tacgtgcagt tcggtgcggg tgtcgggcgg gccggaggcg aagaggtaga cgacgcggac
    18781 ggcggggccg ccgggggcgg acgggccgtc gtggtgggcc gcgaccagcg cgaggcggtg
    18841 gccgtcgacg agcaggtccg cggcgcgctc gggcagttcg tcggggccga tgtcggtcac
    18901 ggtccggggc atgggtcagt gccttccgat gatctcgccg gccgcggaga gcagccgggt
    18961 gagggggccg gtggccaccc ccagggccgc ggccgcgacg agcccggcga ccaggggggc
    19021 cgcggcggcc gccccgagcc ggacgggccc gtcggcgacg gcctccggtt cgggcggcgg
    19081 accgaggacc atgcgggcgg tgcgggtgac gagcgcggcg aaggagacga gggtgaggac
    19141 cagcgcgacg gcgacgacct tgccgtgtcc ggcggtgaat ccggcgcggg cgaggccgag
    19201 ttcggaggcg aagaggctga acggcggcag gccgagcagg gcgaccacgg ccagcccgaa
    19261 ggtggtgccg agggcggggg cctcggccag cagcccgcgc acccgcccga tgcgggcggt
    19321 gcggcggatc cgcaggatgt ggcccgaagc gcagaacgcg acggtcttcg ccagcccgtg
    19381 gcccgcgatg tgcagcaggg cggcggagac ggcgagcggg gtgccgatgg cggtgcccag
    19441 agcgatcagg ctcatgtgtt ccatgctcga ataggccagc atccgcttgt agtcgcgctg
    19501 ggcgagcagc aggacggcgg ccagggccag ggtgagcagg gccgctccgg cgagcagggt
    19561 gcgggtgtag ccggtgccga gggccgcgtc cgcgatgacc ttgtagcgca gcagcccggc
    19621 gaaggcgacg gagagcagga cgccggacat cagcgcggac accggcgcgg gtgcctggct
    19681 gtgggcgtcg ggcagccagg cgtgcagggg ggcgaggccc gccttggcgc cgaagccgag
    19741 gacgatgagg ctcatggcga gccgggtgac ggccgggtcg agccggtcgg cgtgcgcggc
    19801 gagggtgggc cagtccaggg cggaggcctc ggagatgccc gcctgccggg cggcgtagta
    19861 gatcaggacg gtgccgagga aggcgagggc gatcccggcg gaacagatca ccacgtactt
    19921 ccaggcggcc tcgacggagg cccgggtgcg gcggtggccg acgaggaagg cggtgacgat
    19981 ggtggtggcc tcgatggcga tccacaggac gccgaggttg gcggccagga cggccgcgct
    20041 catggccgcg aggaaggcgt ggacgagcag gttgtagcgg cgggcggcac ccgcgtcggc
    20101 ccgctcgtgg gcgaggtgag aggggttcgc ggcgcaggcg agggcggcca ccgcgccgac
    20161 ggcgagcagc agccacacgg tgagggcgtc ggcgcgcagc agccgcccgt acgccgtcac
    20221 cggtccgcgg tccgggacgg tggcggcgag ggcggccccg cagaagagga tggtggccgg
    20281 ggacaccagg ccgagccagg tgccgagcgg ccgggccgcg gtgtcggtcc cggtggcgaa
    20341 cggcggtgcg gcgggcggtc cgtcggtggc gaacggcggt ggcccggggg gtgcggccgg
    20401 gggtccgccg gtgagcgtgg ccggtccccc ggcggccgcg gtggagccgg tggtccgcgc
    20461 gggttcggcc ggtgtccgcg ggggcggcgg ccggtgcgcg agggcggcgg agtgccgggg
    20521 ggcgtgggcc cggcggtacg gccgtacgcc gcgcagcccg gtggcggcgt gggcggccga
    20581 ggtggcgagg ggcaccgcga tgggggcggt cagcagcagt gcggtggtgg cgtgcgtcat
    20641 cagtcgcgta gctcccgcag gtcgtcgatg ccggtgccgc cgaaggcggc ccgcatccgg
    20701 gtggtgagga tctgcaggac gagaacggcg agcaggacgt cgaaggagac gccgagttcg
    20761 acgatcagcg gcactccgga cgcggccagg aaggccgtcg cggtgatgcc gttgtccagg
    20821 agcaggaagc cgaccacctg cgccagggcg cggcgccggg tgaccagggt gaagaagccg
    20881 atcaggacga cggcgaggcc gaccggcagg gcgctcgtcg cgggggtggg gtcgagttcg
    20941 acgaggggcc gggcgacggc gtaggcgagg agggtgagga gggcggcgct gagcagcgag
    21001 gccgcgacgt tgaccagggg ctgggtctcg cgggcctcgc tgacgtcctc ctcgtagtgg
    21061 cgggtggggg gcggggtgcc ggcggcgagg gcgcggcgga tgaggtgggg cagggcgccg
    21121 gcacggagca ggccgatgcc gacggcgacg gcgaggaggt cccagcggcc ctcgtgcacg
    21181 cccagcaggc cggcgacggc ggccagggcc acgccctgga gggcgaagac ctggacgatc
    21241 gaggacagtt ggcgcagcca caggaccacg acggccgcga gcaggaacgc gccgcacgcc
    21301 aggtcgagca gctgggtgta gacgctgtcg ttcatgtgtc cctcactcac tctcctgtga
    21361 ggaagtacga ggcggtgacc gcgagcaggg ccagcaggaa ggatccggcg agcagctcgg
    21421 ggacgcggaa gagccgcagt ttggcccaga acacctcggc ggccgcgagg gcggagccga
    21481 gcagggcgac cttggcggtg agcaggacga gggcgagggc gagggcggcc ggtgaggcgg
    21541 tggtcgcgat gccccagggc gcggacaggg aggcgagcag tccgaggagg acggcgagcc
    21601 tcatctgggc gccgagttcg accagggcga ggtcggggcc cgcgtactcc aggaccatcg
    21661 cttcgtggac catcgtcagc tccaggtggg tggaggggtt gtccacgggc agccggccgg
    21721 tctcggcgag gacggcgacg gccagtgcgg cggtggccag gagccccgcg ggggaggcca
    21781 gccgcaccgg gtcgtggatg ccgccggaga cgatcgcgga caggttggtg gaaccggtcg
    21841 gtatcgacag ggcgaacacg gcgaggagga tggtcggttc gacaagggcg gcgacggtca
    21901 tctcgcggga ggcgcccatg ccgccgaagg cggtgccggt gtccaggccc gcgagggcga
    21961 gggcgaccgt gccgagggcc agcagcgcca ccaccaggat caggtcggcg ctgccgctga
    22021 cgggggtgac ggtggaggcc agggggacga gggcggcgac gacggcggtg gtcgcgacga
    22081 gcaggagggg ggcgacgcgg aaggcgggtc cggtgccgat gggggtgatg gcctccttgc
    22141 ggagcagctt gcgcaggtcc cgccagggct ggacgacgcc ggggccggcc cggccctcca
    22201 tccgggcccg cacctgccgc atcgtgccgg cgagcagcgg cgccccggcg acgacgagga
    22261 cgacctgggc ggtcactgcc gccgtgccga tggctttcac ggtgtctcct cctgcgtctc
    22321 cccctgcgtg ccccgccgtg tgctgccgct caccagcccg ttcaccagcc caccgccagg
    22381 gccagcagga cggcgacgag gccgaagaac ccgtagccga ggtagaggtg cacgctgccg
    22441 gtggccaggc ggcgcgcgct ctggccgagg ccggtgacgg cggcgaggac ggggcggtag
    22501 acacggtgct cgatccggtc ggggatccgg ctctggaagc gcacccgttc caccagatag
    22561 gcggactcgc gcagcggggt gacgttgacg tcctgctcgg gggcgaggac gtcgtcgaag
    22621 acccgctgga ggggttcggc gaacga
//
