LOCUS       NZ_CP031455            21188 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces olivoreticuli subsp. olivoreticuli strain ATCC 31159
            chromosome, complete genome.
ACCESSION   NZ_CP031455
VERSION     NZ_CP031455.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivoreticuli subsp. olivoreticuli
  ORGANISM  Streptomyces olivoreticuli subsp. olivoreticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Complete genome sequence of Streptomyces olivoreticuli ATCC 31159,
            producer of anticancer bestatin and diverse secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2018) Tianjin Key Laboratory of Food
            Biotechnology, College of Biotechnology and Food Science, Tianjin
            University of Commerce, NO.409 Guangrong Road, Tianjin, Tianjin
            300134, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-JUN-2018
            Assembly Method                   :: SMRT Link v. 5.1.0
            Assembly Name                     :: TJCU_BT_311
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: SMRT Link v5.1.0
            Genome Coverage                   :: 145.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003391135.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 04:49:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,562
            CDSs (total)                      :: 7,459
            Genes (coding)                    :: 7,276
            CDSs (with protein)               :: 7,276
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 183
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 183
            Pseudo Genes (frameshifted)       :: 61 of 183
            Pseudo Genes (incomplete)         :: 150 of 183
            Pseudo Genes (internal stop)      :: 18 of 183
            Pseudo Genes (multiple problems)  :: 41 of 183
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:12:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 743898
            Orig. end                         :: 765086
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Hongyu Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21188
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="7"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21188
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21188
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11188](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11188
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    89..102
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.09"
                     /tool="antismash"
     gene            complement(349..1716)
                     /locus_tag="DXZ73_RS03355"
     CDS             complement(349..1716)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="DXZ73_RS03355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_116209537.1"
                     /transl_table=11
                     /translation="MMLRTKITAVVAAAAALAISLAAFMSYRGVSNLVADELERGLDDR
                     TNTVITLLAAGRTPPTRPDTFEQVVSAQGAVRPLAPGRDALPVTPDALRVARTGKGESR
                     ADVVVSGTEYGTLTRPLPGGGAVMAGQSYEGAARVDDQFLWRISWTTAAAIGFAALLGW
                     LVLGRILRPVRRLAVTTQRITTTQDLATPLPPAGSDEIGQLTYSFEHMLAALRRSRAQQ
                     QQLVQDASHELRTPLTSVRGSAELLQRARGRLDPKDEEQILTTLVTETAALDDLVRELV
                     ELATDRYTEEEPEAVDLAVAAEDSAQRFRLRTGRVVLVIEDGANPPVPVRARPRALQRC
                     IDNLLSNAVKFSPEGTPVAVHIGGGKLAVRDQGPGIAPGEQHAVFDRFYRGPRTQATPG
                     SGLGLAIVYDIIAADAGTVFAATADGGGAEVGFDLPPHDQGGSNGPTARRRSRRTP"
     gene            complement(1713..2411)
                     /locus_tag="DXZ73_RS03360"
     CDS             complement(1713..2411)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020555173.1"
                     /locus_tag="DXZ73_RS03360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_116209538.1"
                     /transl_table=11
                     /translation="MTDETGHRRTVMVVEDDPGVRSTLDQLLRFEGYRVLMASDGLEAL
                     GLLGQERPDLAVVDVVMPGLDGLGLCRMLRRRGDRLPVLVLTARHEVGDRVAGLDAGAD
                     DYLAKPFATEELFARIRALLRRTEPPEDSGALTVGDLTLDPASRQAFRGERQLDLTKTE
                     FDVLELLLCHPGVVLSRSQMYERIWGFDFDTTSRSLDVYIGYLRQKTEQGGEPRLIHTV
                     RNVGYTIRPA"
     misc_feature    2415..2429
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            complement(2457..3998)
                     /locus_tag="DXZ73_RS03365"
     CDS             complement(2457..3998)
                     /NRPS_PKS="Domain: Abhydrolase_1 (93-230). E-value:
                     1.4e-18. Score: 59.3. Matches aSDomain:
                     nrpspksdomains_DXZ73_RS03365_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="DXZ73_RS03365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_116209539.1"
                     /sec_met_domain="PF00561 (E-value: 4.8e-20, bitscore: 71.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYKRTARRAGLAVSMMAVTASVLPTATAAAVPAKGPAATVAPAW
                     CPTVGGYQVDCGRLDRPLVAGKPELGKVKVSYAVVRHSAPGPAKGTVAVNPGGPGETSI
                     DKAEGFAWGLEGMLKDHDLLLVDPRGTGKSQPVPCGVTDAEYRFGTRAQQRAAVERCAK
                     NLGPKAAGYTSAATADDIDAIRAHLGVPKLSLYGLSYGTYLMPVYASRHPERVRSIVLS
                     GAYPLELDPLGRPSAQAVSSNLHRVCERSVPVACDGKQAVRDLATTAARLRAEPMTVPI
                     TTGHGVYKKRFTEDKLANLMFEAASSQVGLEPDKPSLLGQLPHALDRFVKGDAAPLRTL
                     VQEEGKTGSTVDQAPYIAVTCNDYRKAWSKDAPLSERWSQYNAALAAVRPGEHGAFSAK
                     GFTEGTTDAGDVCIGWPRENTPDPQPTKLELPDVPVLVLSGDLDANTPEVSGKKAAEQF
                     RNSRYFSVRNMGHVPELELSRCVTGVSSHFLRTGEPGDTSCLRTLPPIAVTPVRG"
     aSDomain        complement(3309..3719)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DXZ73_RS03365_Abhydrolase_1.1"
                     /evalue="1.40E-18"
                     /label="DXZ73_RS03365_Abhydrolase_1.1"
                     /locus_tag="DXZ73_RS03365"
                     /protein_end="230"
                     /protein_start="93"
                     /score="59.3"
                     /tool="antismash"
                     /translation="VNPGGPGETSIDKAEGFAWGLEGMLKDHDLLLVDPRGTGKSQPVP
                     CGVTDAEYRFGTRAQQRAAVERCAKNLGPKAAGYTSAATADDIDAIRAHLGVPKLSLYG
                     LSYGTYLMPVYASRHPERVRSIVLSGAYPLELD"
     gene            4252..4629
                     /locus_tag="DXZ73_RS03370"
     CDS             4252..4629
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006379258.1"
                     /locus_tag="DXZ73_RS03370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_116209540.1"
                     /transl_table=11
                     /translation="MRLVCDPAYDEVDLSASAEELNRLADAVAQGEGLLTSSPGGDGLA
                     GVEVKNAPGPGVLVHLDSERQFLVISGDSTGRSVLADNLRGMASAEDGGHLHVEYPGHD
                     YLVEGSVPLVVNSPHGGMPTR"
     gene            complement(4876..5637)
                     /locus_tag="DXZ73_RS03380"
     CDS             complement(4876..5637)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540177.1"
                     /locus_tag="DXZ73_RS03380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_240351131.1"
                     /transl_table=11
                     /translation="MVGIDWRRLCGRGRCGQACGLLLSLTMLVSITACSQETDDQKLRF
                     LAASEKAQSRRAQEERKIRESIGRLGSVTGVHHVLTRFMDTCAGPASQALWGSDDPQHT
                     LVCDMEAAAYFGVRGDIVEVLPRIRAAAIANWGHQDEHGEDVPYAGGSVRYALDYYRNH
                     GRYPDGALMSIPELESPGLRINWDLAPHQLVDEARPCPPAGYAYFRCELTPSPAATVHA
                     TRTEYGVVLVFEIGTRMGSSAHHYYTVPRRP"
     misc_feature    complement(5611..5613)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5646..5660
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.04"
                     /tool="antismash"
     gene            complement(5761..6699)
                     /locus_tag="DXZ73_RS03385"
     CDS             complement(5761..6699)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019054936.1"
                     /locus_tag="DXZ73_RS03385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_116209541.1"
                     /transl_table=11
                     /translation="MDILQDHLARARASGAVFARTVAEPPWGLRLAGSIQLAVHTVVRG
                     RGWLWLDDPGSAVELVPGEVTLVRGGPDHHIGHEPGAACLEPEEFRARHAHDGESEDPR
                     ATVFLCGAYRFSGDIGSGLLEALPQVLTLSAAVGDPLRDVIALLSHELATPEPGRSIVL
                     DRLLDVLLVLAIRNDFRRSPTAPRWYQASTDPRLKAALQAMHENAGHPWSVPELAAISG
                     LSRAAFARTFRDALGRTPMQYLTDWRMTLARDHLRTGDIGMTAIARTVGYTSPYAFAAA
                     FRRHHGEPPGTWRQRQSLRAEAHPGNDPHAH"
     gene            6811..7665
                     /locus_tag="DXZ73_RS03390"
     CDS             6811..7665
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019054937.1"
                     /locus_tag="DXZ73_RS03390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NmrA family NAD(P)-binding protein"
                     /protein_id="WP_116209542.1"
                     /transl_table=11
                     /translation="MTGSPQTALVLGGTGRTGSLVARKLAERGLGARTAARHGADVLFD
                     WDDPTTHPGALVGVDRLYLVTPVLQVTYADRVAAFLDLAEAAGVHHVTYLSTYGGDQAP
                     PEVDIKSVEVGLAVRGAITHSILRPAWVMQNFSDPHLPVVDGVITVPTGGGTEAFVDAA
                     DIAAVAVETLLTPEAHAGAQYAPTGPQALTVGEVADAIASVTNRPVRHHDIEPGAWIGG
                     AVAAGLVPADYAVMLSWLTGSIISGNGSTPNDDIEKVTGRPPAAFHDFARRNVRAWTSP
                     AAR"
     gene            7668..8108
                     /locus_tag="DXZ73_RS03395"
     CDS             7668..8108
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019054938.1"
                     /locus_tag="DXZ73_RS03395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_116209543.1"
                     /transl_table=11
                     /translation="MPTNNIKDFAALDPFFRIIGEGLAGLVDGEHFFDLLAEDVVVEYV
                     ISVPGYPHRVQGRRAVADLYRGYGDIMVLHSAGELAVHRDPETSVVVLEYAVHGRAVHT
                     GRAYDNHFVSVITVKNRKVTHWRDYMNPVAVFQAIGWPTEER"
     misc_feature    complement(7702..7716)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.28"
                     /tool="antismash"
     misc_feature    8468..8486
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.81"
                     /tool="antismash"
     misc_feature    complement(8492..8505)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.04"
                     /tool="antismash"
     gene            8535..9950
                     /locus_tag="DXZ73_RS03400"
     CDS             8535..9950
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174667.1"
                     /locus_tag="DXZ73_RS03400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_116209544.1"
                     /transl_table=11
                     /translation="MTTPTEQQQAEQQAQLSLSTAAARNLATTTKSVPQMQGISSRWVT
                     RMLPWNEVTAGTYRVNRRLTYTVGRGRVSFVKTGAEVRVVASTLTEVPPLRGFQEESLL
                     TELASRFTQRDFEQGDVLVEAGQPIEEVFLVAHGKLSRIGSGKYGEPTVLGTVADGDHL
                     GEEALRQDEPVWGHTVKATTNGTVLALPWAAFRQLLYRSEALRGHIDSYLTTHQQSVNK
                     KGEADVELASGHVGEPELPGTFVNYDLTPREFELSVAQTVLRVHSRVADLYNDPMDQVE
                     QQLRLTIEALRERQEHELVNNREFGLLHNADYDQRISTRSGPPTPDDLDDLLCMRRSTR
                     MMLAHPRAIAAFGRECNKRGIYPDGVEVNGHLLPAWRGVPIFPCGKIPINGGGHNISSI
                     LALRTGEEDQGVIGLRKTGLPDEYEPGLNVRFMGINDQAVISYLVSTYYSAAVLVPDAI
                     GLLENVEVSRHRD"
     gene            10001..11188
                     /locus_tag="DXZ73_RS03405"
     CDS             10001..11188
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890277.1"
                     /locus_tag="DXZ73_RS03405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_116209545.1"
                     /sec_met_domain="T1TS (E-value: 2.2e-55, bitscore: 187.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLSRAFSTAATHELAGLVTALLAHQGNASPTLPSSPRRVPARF
                     PTGPTGLGTAAARIAPAAEPPRTQPVRPASSGPVPPLYCPPAVRDDPALAKEVNDRLVS
                     WAAGVGIYQGRSDELRATDFGRLLMLTHPDTDDPDRLLAAAKCGLAEWAADDHYCDDES
                     AGADPRALGPRLCVANAAVDPAHLPLRYAPELERAMRADPVLTALRSALDHIARYAAPA
                     QLGRLAHEISGLFAGFNAEAGWRTAERVPPVWEYLVNRQCNSFLPMVTLVDAVGGYEVP
                     AAEYYAPRVRRAFSMACTAATLVNDLYSMARESAGPGLEFNLPTVIATEEKCALEEAVR
                     RSVLVHDELVHTFEAEAAVLAADGSPELRRFLAGTWAWLGGNREWHSTTPRYNAA"
     gene            11216..12076
                     /locus_tag="DXZ73_RS03410"
     CDS             11216..12076
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841325.1"
                     /locus_tag="DXZ73_RS03410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_116209546.1"
                     /transl_table=11
                     /translation="MASMIEHTAKVLRTSYQKSVAAYWDSERAPVNLRLGEVDGLYHHH
                     YGIGDYDPSVLEGPENTRDRRVIEELHRLETAQAEVLLDHLDGITAQDRLLDAGSGRGG
                     TSFMAHQRFGCAVDGVTISEHQVGFANSQAEERGVADRVRFHFRNMLDTGLATGSRRAI
                     WTNETTMYVDLTELFGEFSRLLEYGGRYVCITGCYNDVTGGRSKAVSRIDEHYTCNVHP
                     RSAYFKALAANGLVPINVVDLTAQTIPYWELRARSSVATGIEDPFLTAYKEGSFHYLLI
                     AADRI"
     gene            complement(12163..13086)
                     /locus_tag="DXZ73_RS03415"
     CDS             complement(12163..13086)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="DXZ73_RS03415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_116209547.1"
                     /transl_table=11
                     /translation="MVESGQREVIDIAYDNPDRLHTGVEVLTFDTLKLRLKSSVARRPS
                     RLDFHQVMLVRGGEGTTMVDFVTHPCARGTLLHLRPGQVQRLPSGTNGRPADLDAVLLL
                     FTADFPPPLPATHEVLHGFGPAAWRLPPDEFDAFDRTVTEMETEYRTLRDGQPPDTTAP
                     AGTDAELTGALLRQLLGALLIRMARLTDPAGRPVPAAPGTEVHLAFRRELEHSFTTTRN
                     VEDYAARLGCSPRTLTRACLAATGRSAKQLADARVALQAQRLLAHTDLPVAAIGRALGF
                     TEATNFGKFFARETGRPPGDFRRAQR"
     gene            13225..13605
                     /locus_tag="DXZ73_RS03420"
     CDS             13225..13605
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02246.1"
                     /locus_tag="DXZ73_RS03420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SgcJ/EcaC family oxidoreductase"
                     /protein_id="WP_116209548.1"
                     /transl_table=11
                     /translation="MFPVVTDPAKLPILFQDALNAGDVDGVLALFAPDAGMRTVTGEHI
                     AGAEALRAEISGTVAARGRLTNVRRHTLVGAETALLVTDWTMEIDGPGGERIAPTGTTA
                     NIARQYADGGWRFTVLNPLGTA"
     gene            complement(13753..14976)
                     /locus_tag="DXZ73_RS03425"
     CDS             complement(13753..14976)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012744.4"
                     /locus_tag="DXZ73_RS03425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_162890003.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.7e-25,
                     bitscore: 88.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVAWITASFPPEVSGISLGNVARAQWFAAQQDVRLCLLVPEPTD
                     GSSLAVAGTPGLELFPYAAKPWLPYPMLRVPRRAALAQIDSALEKIAPDLVVVIDPERS
                     FVFGSWGIPGHAYARRHGVPYVAQYQGDHFNFARSYPVWRHLATSMFPPIMRYVYRHFD
                     TAICATPYAEETLGGLSDVRIEQVPFDSVDIDSFGADRADPAVLYKLAPRYDGRGKRVL
                     YLGRLAREKRLDLVIGAFLRLSAMPGNEDLSLFIAGDGPSDITAQITQLAAASPRIHLL
                     GFVRGADRSALYASCDAFCTACPYETFGCTVVEAMASGIPVVNPSSGGITSVLSNGHNA
                     YLFQPDNPDALLSALRAALDDNGHVTGQARIDAAQFTTEKCCTHLLTSYQRLTAMTTRQ
                     REKCDYCR"
     misc_feature    complement(14869..14871)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15321..16577)
                     /locus_tag="DXZ73_RS03430"
     CDS             complement(15321..16577)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="DXZ73_RS03430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_116209550.1"
                     /sec_met_domain="p450 (E-value: 1.3e-07, bitscore: 29.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTTTHSGCPAHTPGAIARHAADDLHAAYAHLRREHPVYHDPD
                     LDLWVVSRHRDIDEVLRDRHRAFTPAHSYDPIQPTDPEAARIYTAVHDVPVAASTDPPT
                     HTRYRDALTAVWPTSANQLAPWHSHIEKRALQAAQALAARPDHTGELTAHYARPLTARI
                     MSDLIGIAPEDEQCVIAGSSGMADLLWSFQPLADQQRCAQAVVDLWNLCTGLVAQRRSR
                     PQDDLTTTWISYRDDAGAPLTDAEIASTLMEVLTTNAETLALLTTTALQHLLTGDGYGH
                     LTQHPEQAPAAVEETLRLDPPLIGWLRTTTRPVALSGTDLPQGARILLLMHSAAHDEAH
                     SVHATHTFDHRREDTPPTLNFGAGIHYCPGAQYTRLVAHHALAVLTRTLPGLTLTCRTP
                     APRPANLILRRPTQLHVTW"
     gene            complement(16609..17478)
                     /locus_tag="DXZ73_RS03435"
     CDS             complement(16609..17478)
                     /EC_number="2.1.1.-"
                     /NRPS_PKS="Domain: oMT (32-177). E-value: 8.3e-24. Score:
                     75.4. Matches aSDomain: nrpspksdomains_DXZ73_RS03435_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014414.4"
                     /locus_tag="DXZ73_RS03435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_116209551.1"
                     /sec_met_domain="PCMT (E-value: 2.6e-06, bitscore: 26.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTPVVPAALLTSAEVAAWYEASDELCKMISGDSFHYGLWQPGD
                     LDEPLPARQLATRAQNRMTDFFCDLLAIEPGEHLLDVGCGHGSPALHAAHERRIQVTGC
                     SISQAQLTEAARRATAAGMADRVRFGLGDAMDLPHETGSFDAVWALDSFPHLNDPVKGL
                     RELARTARPGASMLVTFYTQRVPATDAELTMCRDAFAFCPLPTHDQVLGQIRAAGLTLE
                     QTHDLSEHIAPTCQAYGRIYQDNRALIAEKFGTPYADTMDTALADTLTFLTDKTGYLAC
                     LLRHPAHS"
     aSDomain        complement(16948..17382)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DXZ73_RS03435_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="8.30E-24"
                     /label="DXZ73_RS03435_oMT.1"
                     /locus_tag="DXZ73_RS03435"
                     /protein_end="177"
                     /protein_start="32"
                     /score="75.4"
                     /tool="antismash"
                     /translation="GDSFHYGLWQPGDLDEPLPARQLATRAQNRMTDFFCDLLAIEPGE
                     HLLDVGCGHGSPALHAAHERRIQVTGCSISQAQLTEAARRATAAGMADRVRFGLGDAMD
                     LPHETGSFDAVWALDSFPHLNDPVKGLRELARTARPGASML"
     gene            complement(17490..18980)
                     /locus_tag="DXZ73_RS40250"
     CDS             complement(17490..18980)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="DXZ73_RS40250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_116209552.1"
                     /transl_table=11
                     /translation="MTLEATALPATVPQPGSGQCAARPFDVLGKTYEDTYAHLPEQLAA
                     IDWLLARLPARAKMMDIGSGTGRPTADLIAAQGHQVTGYDVSQTMVDLARTQVPGARFE
                     LADVRELPETPGQWDAITAFFPLLQMPRADLDATLARIADWLAPGGLFVLATVPFDAED
                     EEIQWMGQTVRCTSYPSETFGRLLRTAGLDIAHEQLSVFHPDFPGMGPEEHLFVYATKP
                     GGPAAPAHTLAGPYPLPASYRGPHELSEQGWLGMEARFERQDIKLVVDALAANTRVLDV
                     GGGTGAVVREIAARLGSVTTVEPHAAREESMRPLAAHGVTVLSGRSEQLPLPDAQFDAA
                     VATWVLHYTDDPEASVAEMARTVDRAHPEAKIVLVQGAPDNELIELWNRTCAPLIGEPR
                     DHQGYLLTLAARVLAEHGFDDISFTRARVDVVFPEEGPENKANAAAEVLADFWNTGHPR
                     LGQLREALLPALREHFAGGTDRFNDDAVMLTARPRTAR"
     gene            19129..19929
                     /locus_tag="DXZ73_RS03445"
     CDS             19129..19929
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS03445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116209553.1"
                     /transl_table=11
                     /translation="MTTTIPDSHAAYFAFRDRLLGELRTTVLTGEQLCEAGRLIYGRAE
                     GLSLFGIPAPRMESAGIQLLGRTAIECCVDDYASAVADALADVHATIPDEGEEPLIVDL
                     FCGSGNFSHHLGIRLGTVVHAAELDPGVHDATRHNLERIEADTRLHLGDYGDLLGKLLP
                     RGPRDTYFVEPPWGPAFTPAGLDLTRTAPPVPRILDDIRRSRNGRPCLVAIKTNDQIAD
                     NSLARSFVGARHLRSITPRPVLPHGANMDFHLYRLEQGADSCGM"
     gene            complement(20071..20790)
                     /locus_tag="DXZ73_RS03450"
     CDS             complement(20071..20790)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003979182.1"
                     /locus_tag="DXZ73_RS03450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_116209554.1"
                     /transl_table=11
                     /translation="MASRSQSTRARSPEAKRAREATILAAAARLATVSGIRSVTLTDIA
                     TEVGMHKSAMLRYFETREEIFLRLAAAGWVEWSQAVRGQLADAAPGTDDENSADAVNGV
                     DREPRLQAVAGLLAESLVARPLFCDLLAHTPMNLERNVSLESVRSFKLTAIAEVAAVGE
                     ALRRVAALSPAQAGDVVATATAMAGALWQMAAPGTELRRLYESDPGLAHAVVDVAPRLT
                     DILSALLRGYSAGGEAE"
ORIGIN
        1 cctcggacgg cagcgcctac cgcgagtacg tactgactcc gaagggcaag gcgctcttcc
       61 ccgtcatcgt ggcactgcga cagtggggcg aacagaactt cttcaccccc ggcgaatcac
      121 actcggagtt ggtcgaccgc cgacagggac atcgcctccg cgcactggaa gtgctgtcct
      181 cggacgggcg acggctggac cccgacgaca ccaccgtcca caagatctcc acccagtgac
      241 ccgagccgga gacccggtga tggctcacac gtcctcagcc ggtacccgat cgcctgcggt
      301 gtcgcctccc aggggccctt ggccaagccc tgggccccgc ccgccggttc aaggtgttct
      361 ccgggaacgc ctccgtgccg tcggcccatt cgaaccgccc tggtcgtggg gcgggaggtc
      421 gaagccgacc tccgcgccgc cgccgtccgc cgtggcggcg aagacggttc cggcgtcggc
      481 cgcgatgatg tcgtacacga tggccagacc gagaccggaa ccgggcgtcg cctgggtccg
      541 ggggccgcgg tagaagcggt cgaagacggc gtgctgctcg ccgggcgcga tgcccgggcc
      601 ctgatcccgt acggccagct tgcccccgcc gatgtgcacg gcgaccgggg tgccctcggg
      661 actgaacttc accgcgttgc tcagcaggtt gtcgatgcac cgctggagcg cgcgcggccg
      721 ggcacgcacc ggcaccggcg ggttcgcacc gtcctcgatg acgaggacga cgcgcccggt
      781 ccgcaggcgg aagcgctgcg cgctgtcctc cgcggcgacg gcaaggtcga cggcctcggg
      841 ctcctcttcc gtgtagcggt cggtggccag ctcgacgagc tcgcgcacca ggtcatcgag
      901 ggcggcggtc tcggtgacca gggtggtgag gatctgctcc tcgtccttgg ggtcgagcct
      961 gccgcgcgcc cgctgcagca actcggcgct cccgcgcacc gaggtgagcg gcgtacgcag
     1021 ctcgtggctg gcgtcctgga ccagttgctg ctgctgggcg cgggagcggc gcagcgcggc
     1081 gagcatgtgc tcgaagctgt acgtcagttg gccgatctcg tcggatccgg cgggcggcag
     1141 cggcgtggcg aggtcctgcg tggtggtgat gcgctgggtg gtgacggcca gtcggcggac
     1201 cggccgcagg atccgtccca ggacgagcca gccgaggagc gccgcgaagc cgatggcggc
     1261 cgcggtggtc caggagatcc gccacaggaa ctggtcgtcg acgcgcgcgg cgccctcgta
     1321 gctctggccg gccatgaccg ccccgccgcc gggcaggggt ctggtcaggg tgccgtactc
     1381 ggtgccggag acgacgacgt ccgcgcggct ctctcccttc cccgtccggg ccacgcgcag
     1441 cgcgtccggc gtgaccggca gggcgtcccg gccgggtgcc agcggtctta ccgccccctg
     1501 ggcggacacg acctgctcga acgtgtccgg ccgggtgggc ggggtccggc cggcggccag
     1561 gagggtgatg acggtgttgg tacggtcgtc gagccctcgc tcgagctcgt cggcgaccag
     1621 gttgctcacg ccccggtacg acatgaaggc ggcgagggag atggcgagcg cggcggccgc
     1681 ggcgacgacg gcggtgatct tcgtacggag catcatgcgg gccggatcgt gtagccgacg
     1741 ttgcggacgg tgtggatcag ccggggctcg cctccctgct cggtcttctg gcgcaggtag
     1801 ccgatgtaga cgtcgaggga gcgggacgtg gtgtcgaagt cgaagcccca gatgcgctcg
     1861 tacatctgcg accggctgag gaccacgccc ggatggcaca gcagcagttc cagtacgtcg
     1921 aactcggtct tcgtcaggtc cagctgccgc tccccgcgga acgcctgccg ggacgcgggg
     1981 tccagggtga ggtccccgac tgtcagggcc ccgctgtcct cgggcggctc ggtgcgccgc
     2041 agcagcgcgc gtatgcgggc gaagagctcc tcggtcgcga acggcttggc gaggtagtcg
     2101 tcggcgcccg cgtcgagtcc cgcgacccgg tcgcccacct cgtgccgggc cgtcaggacc
     2161 aggacgggca gccggtcgcc gcgcctgcgc agcatccggc acaggccgag gccgtcgagg
     2221 cccggcatga ccacgtccac caccgccagg tcgggccgct cctgtcccag gaggccgagg
     2281 gcctccaggc cgtcggaggc catcagcacc cggtagccct cgaagcgcag cagctggtcc
     2341 agggtgctgc gcactcccgg gtcgtcctcg acgaccatca ccgtccggcg gtgccccgtt
     2401 tcatcggtca tgtgatcatc ttcgtcggtg gtggaagcgg tcagggcacc ggcccgtcag
     2461 ccgcggaccg gagtgacggc gatcggcggg agggtgcgca ggcaggaggt gtcgcccggc
     2521 tcgccggtgc ggaggaagtg cgaggagacc ccggtgacgc agcggctcag ctccagctcg
     2581 ggcacgtgcc ccatgttgcg gaccgagaag taccggctgt tgcggaactg ctcggcagcc
     2641 ttcttcccgc tcacctcggg cgtgttggcg tcgaggtcgc cggagaggac gaggaccggg
     2701 acgtccggca gctcgagctt cgtgggctgc gggtcagggg tgttctcacg cggccagccg
     2761 atgcacacgt cgccggcgtc cgtggtgccc tcggtgaagc ccttggcgct gaacgccccg
     2821 tgctcaccgg ggcgtacggc ggccagcgcg gcgttgtact ggctccaccg ctcggacagc
     2881 ggcgcgtcct tcgaccaggc cttgcggtag tcgttgcagg tgaccgcgat gtacggcgcc
     2941 tggtccaccg tgctgcccgt cttcccctcc tcctggacca acgtccgcag cggcgcggca
     3001 tcgcccttca cgaagcggtc gagggcgtgg ggcagttggc cgagcagcga gggcttgtcc
     3061 ggctcgaggc cgacctggct gctggccgcc tcgaacatca ggttggcgag cttgtcctcg
     3121 gtgaaccgct tcttgtagac gccgtgtccg gtggtgatcg gcaccgtcat gggctcggcg
     3181 cgcagccgcg cggccgtggt ggccaggtcc cgcacggcct gcttgccgtc acatgcgacg
     3241 gggacgctgc gctcgcacac ccggtgcagg ttcgacgaga ccgcctgggc gctgggccgc
     3301 cccagcgggt cgagctcgag ggggtaggcg ccggacagga cgatggagcg cacgcgctcg
     3361 gggtggcggg aggcgtacac cggcatcagg tacgtgccgt aggacagccc gtacaggctg
     3421 agcttcggta cgccgaggtg ggcgcggatc gcgtcgatgt cgtcggcggt ggccgccgag
     3481 gtgtatccgg cggccttggg cccgaggttc ttggcgcacc gttcgaccgc ggcccgctgc
     3541 tgggcccgcg tgccgaagcg gtactcggcg tcggtgaccc cgcacgggac cggctgcgac
     3601 ttcccggtgc cgcgcgggtc gacgagcagc aggtcgtggt ccttcagcat gccctccagg
     3661 ccccaggcga acccctcggc cttgtcgatc gaggtctcgc ccgggccgcc cggattgacg
     3721 gcgacggtgc ccttggcggg gccgggcgcg ctgtggcgta cgaccgcgta actcaccttg
     3781 accttgccga gctccggctt ccccgcgacg agcgggcggt ccagccggcc gcagtcgacc
     3841 tggtacccgc ccacggtcgg gcaccaggcg ggtgccaccg tggccgcggg ccccttcgcg
     3901 ggcaccgcgg cggcggtcgc ggtcggcagc accgaggccg tcaccgccat catgctcaca
     3961 gccagccccg cacgccgcgc cgttctcttg tacgtcattg ccctctcctc tgcctcgggt
     4021 tcctcggact tcccggatcc cccggtgttc ctcggttgcg ggcacaacgt tgccgggcgt
     4081 acttcgcagg cacggcagag cgacggcaaa agcgtgtaag aaaccggagc ggtgcgtcag
     4141 aggtcgttcg gtggtggacc gtcagctccg ctggccggcc ttgccgaccc ggacgcgtga
     4201 cggacgatct tgcgggcatc atgggagtcc gatcttgaag gagtgacgcc cgtgagactg
     4261 gtctgcgacc ccgcatacga cgaagtggat ctctccgcgt cggcggaaga actgaaccgc
     4321 ctggcagacg cggtggccca gggcgagggg ctgctcacct cttcgccggg cggcgatggc
     4381 ctggcggggg tcgaggtcaa gaacgctccc ggccccgggg tccttgtcca cctggactcc
     4441 gagcggcagt tccttgtgat cagcggtgac tccaccggca ggtcggtgct cgcggacaat
     4501 ctgcgcggca tggcctctgc cgaggacggc ggtcacctcc acgtcgagta ccccgggcac
     4561 gactacctcg ttgaggggtc ggtgccgttg gtggtcaaca gcccgcacgg gggcatgcca
     4621 acccggtgag ctggtggctg ctcgatgcga tcagtgacgc aggcaaccag ctaccggatg
     4681 accggtcttg ttgttgcgcc agatcccggc ggccatcgcc aggacccgct gggccacctg
     4741 gatggcgacg acccccgaag gttcgaccgc cgtgttcctc caggtcgagt cggcccttga
     4801 aagagctcgg gctgggccgc cgagatcgaa cgcacaacgc ccaggggctc accgcccgct
     4861 gaacccgccg gtactctacg ggcggcgagg cacggtgtag taatggtgcg cggatgagcc
     4921 catccgcgtg ccgatctcga agaccagcac gacaccgtac tcggtgcgcg ttgcatggac
     4981 agtcgctgcc ggacttgggg tgagttcgca gcggaagtaa gcgtatccgg ccggtgggca
     5041 cgggcgtgct tcatcgacca gctggtgggg cgcaaggtcc cagttgatcc gcaggccagg
     5101 ggattcgagt tccggtatgg acatcagagc tccgtccggg taccggccat ggttgcggta
     5161 gtagtccagc gcgtaacgca ccgatccgcc ggcatacggc acgtcttcac catgctcgtc
     5221 ctggtgaccc cagttcgcga tggcagcagc gcggatcctg gggagcactt cgacgatgtc
     5281 gccccggacg ccgaagtagg cggcggcctc catgtcacag acgagggtgt gctgaggatc
     5341 gtccgagccc cagagagctt gtgaggcagg tccggcacac gtgtccatga agcgggtcag
     5401 cacatgatga acgccggtca cggagcccag gcggcctatc gactcccgta tcttccgctc
     5461 ttcctgcgcc cttctggact gggccttctc cgatgcggcc aggaagcgca gtttctggtc
     5521 atcggtctcc tgtgaacagg ccgtgatcga caccagcatt gtcagcgaga gcagcaaccc
     5581 gcatgcctgc ccgcaacgcc cacgcccgca taacctgcgc caatcgattc ccaccatgac
     5641 cgttccccca ccatgtgggc ccctagacgg gccagcagct gtgttctgat tcgcctcacc
     5701 accgacaagg ccatccaccc tacgccggcc ttggctctgg cgtgggagag tcgggcagtg
     5761 tcagtgggcg tggggatcgt tcccggggtg tgcctccgct cggagcgact gccgttgccg
     5821 ccaggtcccg ggcggctcgc cgtggtggcg tcggaaagcg gccgcgaacg cgtagggcga
     5881 cgtgtagccg acggtgcggg cgatggccgt catgccgatg tcgccggtgc gcaggtggtc
     5941 gcgggcgaga gtcatccgcc agtcggtcaa gtactgcatg ggcgtccggc cgagggcgtc
     6001 gcggaaggtg cgtgcgaagg ccgcccggga caggccgctg atcgcggcga gttcgggaac
     6061 cgaccaggga tggccggcgt tctcgtgcat cgcctgcaga gcagccttca accgggggtc
     6121 cgtggacgcc tggtaccagc ggggtgcggt cgggctgcgg cggaagtcgt tgcggatggc
     6181 gagcaccagg aggacgtcga ggagccggtc cagcacgatg gaccggccgg gttcaggggt
     6241 ggccagctcg tgcgacagca gcgcgatcac gtcccgcagc ggatcgccga ccgccgccga
     6301 cagggtcagt acctgcggca gtgcctccag cagcccgctg ccgatgtcgc ccgagaaccg
     6361 gtaggcaccg cagaggaaga ccgtcgcccg agggtcctcg gactccccgt cgtgggcgtg
     6421 ccgggcccgg aattcctccg gttcgaggca ggcggcgccc ggctcgtgcc cgatgtggtg
     6481 atcggggccg ccgcggacga gcgtcacctc ccccggcacg agttccaccg cgctgccggg
     6541 gtcgtcgagc cacagccatc ccctgccccg gacgacggtg tgcacggcca gttggatcga
     6601 accggccagc cgcagccccc acggcggctc ggccaccgtc cgggcgaaga cggcgccgga
     6661 ggcccgtgcc cgcgcaaggt gatcctgcag tatgtccacg cgatcagtat cagcgagaca
     6721 accacgctgg gcacaggtcc gagcgtttga cgtaaaagaa tgagcgatgc gcgcattgat
     6781 tcactcatgg agcgctctca cgattgatcc atgactggat caccgcagac cgcactcgtc
     6841 ctcggcggca ccgggcggac cggctcgctc gtggcgagga agctcgccga gcggggactg
     6901 ggtgcccgca ccgcggcgcg ccacggcgcc gacgtgctgt tcgactggga cgacccgacc
     6961 acccaccccg gtgccctcgt cggcgtcgac cggctctacc tcgtcacacc cgtcctgcag
     7021 gtcacctacg ccgaccgggt ggccgccttc ctcgacctcg ccgaagccgc aggggtgcac
     7081 cacgtcacgt acctcagcac ctacggcggc gaccaggcgc caccggaggt cgacatcaag
     7141 tccgtagaag tcggcctcgc cgtccgaggg gccatcacgc attccatcct gcgcccggca
     7201 tgggtgatgc agaacttcag cgacccgcat ctgccggtcg tcgacggggt gatcacggta
     7261 ccgaccggcg gcggcacgga agccttcgtc gacgcggccg acatcgccgc agtcgcggtc
     7321 gagacgctgc tcacccccga ggcccacgcc ggcgcgcagt acgcacccac cggcccgcag
     7381 gctctcacgg tcggcgaagt cgccgacgcc atcgcctccg tgaccaaccg gcccgtcagg
     7441 caccacgaca tcgaacccgg cgcgtggatc ggcggtgcgg tcgcggccgg cctcgttccc
     7501 gccgactacg cggtgatgct cagctggctg accggcagca tcatctccgg taacggctcc
     7561 acgcccaacg atgacatcga gaaggtcacc ggccggccac cggccgcctt ccacgacttc
     7621 gcccggcgca acgtccgcgc ctggacctcc ccggcggccc ggtgaccatg cccaccaaca
     7681 acatcaagga cttcgcggca ctggacccgt tcttccggat catcggcgag ggtctggcgg
     7741 gcctcgtcga cggtgagcac ttcttcgacc tcctggccga ggacgtggtc gtcgaatacg
     7801 tgatctccgt acccggctat ccgcaccggg tccagggacg ccgggcggtt gccgacctgt
     7861 accgcggcta cggcgacatc atggtcctgc acagcgcggg cgaactggcc gtccaccgcg
     7921 atcccgagac atccgtggtc gtactggagt acgcggtgca cggacgggca gtccacaccg
     7981 gacgggccta cgacaaccac ttcgtctccg tgatcaccgt caagaaccgc aaggtgacgc
     8041 actggcggga ctacatgaac cccgttgccg tcttccaggc catcggatgg ccgacggagg
     8101 agcgctgaag gagagaagag ctcgaacctg ccgaacaaac cagtgaagct tcccgggtgg
     8161 ggctgcgctg cgccaggcca atgtccgaga actcgatgtg cgccgggagg cgcagacgca
     8221 gacgtcaccc acgctgcact cgcacggccc ggaacacgcg tcggacgccg acaggaaaca
     8281 gaccgatcga gcttacgatt ccacgggagc gcgcattcga atccctcgtc tccaccactc
     8341 ctcggaaagt tcaacggata cccaggtacg acacacgcgc cgccgcaaac ccccaggcga
     8401 acaacctcaa ccgtgttttc agcaggcgca gttgtcttgc cgggttgtgt tccacttccg
     8461 gcacgccgta gccgaggctc acctcatcgg gttttcatac ttatcgccga gatgttcatg
     8521 gcgaaaggaa acccatgacg acaccaacag aacagcaaca ggcagaacag caagcacagt
     8581 tgagcctcag cacggcagcc gcccgcaatc tggcgacaac caccaagtcc gtaccgcaga
     8641 tgcagggcat cagctcgcgc tgggtgaccc gcatgctgcc ctggaacgaa gtcaccgccg
     8701 gtacataccg ggtcaaccgg cggctgacct acaccgtggg gcgaggacgg gtgagtttcg
     8761 tcaagaccgg cgcagaagtc cgcgtcgtgg cgtccacgct caccgaagtg cctccactgc
     8821 gcggcttcca ggaggagagc ctcctgacgg aactggcctc gcgtttcacc cagcgggact
     8881 tcgaacaggg cgacgtactc gtcgaggccg ggcagccgat cgaagaggtc ttcctcgtcg
     8941 cccacggcaa actcagcagg atcggttccg gcaagtacgg cgaacccacg gtgctcggta
     9001 ccgtcgccga cggtgaccac ctcggcgaag aggccctccg gcaggacgag ccggtctggg
     9061 gacacacggt caaggccacc accaacggca ctgtccttgc cctgccctgg gcggccttcc
     9121 ggcaactcct ctaccgctcc gaggcgctgc gcggccacat cgacagctac ctcaccaccc
     9181 accagcagtc ggtcaacaag aagggcgagg ccgacgtcga gctggcctcg ggccacgtgg
     9241 gcgagcccga actccccggc accttcgtca actacgacct cacgccccgc gagttcgagc
     9301 tgagcgtcgc gcagaccgtg ctccgcgttc acagcagggt cgccgacctc tacaacgacc
     9361 cgatggacca ggtcgaacaa cagctgcggc tcaccatcga ggcgctccgc gagcgccagg
     9421 agcacgagct cgtcaacaac cgcgagttcg ggctgctcca caacgccgac tacgaccagc
     9481 gcatctccac ccgctccggc ccgcccaccc ctgacgacct cgacgatctg ctgtgcatgc
     9541 gccgcagcac ccggatgatg ctcgcccacc cacgcgccat cgccgcgttc ggccgcgagt
     9601 gcaacaagcg cgggatctac cccgacggtg tcgaggtcaa cggacacctg ctgcccgcct
     9661 ggcggggcgt gccgatcttc ccctgcggca agatccccat caacggcgga ggccacaaca
     9721 tctcctccat cctcgccctg cgcaccggcg aggaggacca gggcgtcatc ggcctccgca
     9781 agaccgggct ccccgacgag tacgaacccg gtctcaacgt acggttcatg ggcatcaacg
     9841 accaggccgt catctcctac ctcgtcagca cctactactc ggcagccgtc ctggtccccg
     9901 atgccatcgg cctgctcgag aacgtcgagg tctcccgtca ccgcgactga accgtccgcc
     9961 gcctcacggt tccggcgagc gagaacgtaa ggagacccgg ttgtcactgc tgtcccgcgc
    10021 cttctccact gcggccaccc acgagcttgc cggcctggtg accgcgctgc tggcccacca
    10081 ggggaacgcc agccccaccc tgccgtcctc accgcgccgg gtgccggccc gcttccccac
    10141 cggtcccacc gggctgggga cggccgccgc ccgaatagca ccggcggccg agccgccccg
    10201 gacacagccc gtacgaccgg catcgagcgg gccggtaccc ccgctgtact gcccacccgc
    10261 cgtccgagac gaccccgccc tcgcgaagga ggtgaacgac cgcctggtct cctgggccgc
    10321 cggcgtgggc atctaccagg gccgctcgga tgagttgcga gccaccgact tcggacgcct
    10381 gctgatgctc acccaccccg acaccgacga tcccgaccgg ctgctggccg ccgccaagtg
    10441 cgggctcgcg gaatgggcgg ccgacgacca ctactgcgac gacgaatccg cgggagccga
    10501 tccgcgggcg ctcggccccc ggctgtgcgt cgccaacgcc gccgtggacc ccgcccacct
    10561 cccgctccgc tacgccccgg aactggaacg cgccatgcgc gccgaccccg tcctgaccgc
    10621 cctgcgctcg gccctcgacc acatcgcccg ctatgccgcc cccgcccagc tcgggcggct
    10681 cgcccacgag atatccggcc tcttcgccgg cttcaacgcc gaggccggct ggcgcaccgc
    10741 cgaacgcgtg cccccggtct gggagtacct cgtcaaccgc cagtgcaaca gctttctgcc
    10801 gatggtcacc ctcgtcgacg ccgtcggcgg ctacgaggtc cccgccgccg agtactacgc
    10861 cccccgggtg cgccgcgcct tcagcatggc ctgcaccgcc gccacactcg tcaacgacct
    10921 ctactccatg gcacgcgaga gcgccggccc cgggctggag ttcaacctcc cgacggtgat
    10981 cgccaccgag gagaagtgcg cgctcgaaga ggccgtacgc cgcagcgtcc tcgtccatga
    11041 cgagctcgtc cacaccttcg aggccgaggc cgccgtcctc gccgccgacg gctcgcccga
    11101 gctgcgccgc ttcctggccg gcacctgggc ctggctcggc ggcaaccgcg aatggcacag
    11161 caccacccca cgctacaacg cggcatgatc gccgcgcaga acagaggagt tccccatggc
    11221 ctcgatgatc gaacacaccg ccaaggtcct ccgcacctcc taccagaagt cggtcgcggc
    11281 gtactgggac agtgagcggg cccccgtcaa cctccgcctc ggcgaggtcg acggcctcta
    11341 ccaccaccac tacggcatcg gggactacga cccgtccgtg ctcgaaggcc ccgagaacac
    11401 ccgggaccgg cgggtcatcg aggaactcca ccggctggag accgcccagg ccgaggtcct
    11461 tctcgaccac ctcgacggca tcacggccca ggaccggctc ctcgacgccg ggtccggccg
    11521 cggcggcacc agcttcatgg cacaccagcg cttcggctgc gcggtggacg gcgtgacgat
    11581 ctccgagcac caggtcggct tcgccaactc ccaggccgag gaacggggag tggccgaccg
    11641 ggtccgcttc cacttccgca acatgctcga caccggcctc gcaaccggct cccgccgggc
    11701 catctggacc aacgagacca cgatgtacgt cgatctcacc gagctcttcg gcgagttctc
    11761 ccgcctgctg gagtacggcg gccggtacgt ctgcatcacc ggctgctaca acgacgtcac
    11821 cggcggccgc tccaaggccg tcagccgcat cgacgagcac tacacctgca acgtccatcc
    11881 ccgcagcgcc tacttcaagg ccctcgccgc caacggtctc gtccccatca acgtcgtcga
    11941 tctgaccgcc cagaccattc cgtactggga gctacgggcg cggtcctcgg tggcgaccgg
    12001 gatcgaggac cccttcctga cggcgtacaa ggagggcagc ttccattacc tcctgatcgc
    12061 ggcggaccgc atctgacctc ccctcacgag gccccggcgc cggactcctc ccccggtacc
    12121 ggggccctac gggacgctgg agaggctgct tcgagtcctc tctcaccgct gggcgcggcg
    12181 gaagtcgccc ggggggcggc cggtctcgcg ggcgaagaac ttgccgaagt tggtggcttc
    12241 ggtgaagccc agtgcgcggc cgatcgcggc cacgggcaga tcggtgtggg cgagcagccg
    12301 ctgcgcttgc agggcgacgc gggcgtcggc gagctgcttg gcgctgcggc cggtggcggc
    12361 caggcacgcg cgtgtcaggg tccgggggga gcagccgagc cgcgccgcgt agtcctcgac
    12421 gttgcgggtg gtggtgaagg agtgttccag ctcgcgtcgg aaggcgaggt ggacctcggt
    12481 gccgggcgcg gcggggacgg ggcgtccggc cgggtcggtg aggcgcgcca tgcggatcag
    12541 cagcgcgccg aggagttggc gcagcaacgc tccggtcagt tcggcgtcgg tgccggcggg
    12601 cgctgttgtg tcggggggct gcccgtctcg cagtgtcctg tattccgttt ccatctccgt
    12661 cacggtgcgg tcgaaggcgt cgaactcgtc gggcggcaga cgccatgcgg ccgggccgaa
    12721 tccgtggagc acctcgtgcg tcgcgggcag aggtggcgga aagtccgcgg tgaacagcag
    12781 caggacggcg tcgaggtccg cggggcggcc gttcgtaccg gaaggcaggc gctgcacctg
    12841 tccgggccgc aggtgcagca gcgtgccacg ggcgcacggg tgcgtgacga aatcgaccat
    12901 cgtggtgccc tcgccgccgc gcacgagcat gacctggtgg aagtcgaggc ggctcggtcg
    12961 gcgcgcgacc gagctcttga ggcgcagctt caacgtgtcg aaggtcagta cctcgacgcc
    13021 ggtgtgcaac cggtcggggt tgtcgtaggc gatgtcgatg acttcgcgct gtccactttc
    13081 gaccatcacg ggtcctgacc ctacctcgtc cggagggcgg ccgcgggggc atcgtggagt
    13141 cacggccgga cggcgggcgc cacaccgggc accgcgccgg aaagccgtca ccaccttccc
    13201 ttcgtgaagt aaggacctct catcatgttc cctgtcgtca ccgaccccgc aaagctgccg
    13261 atcctgttcc aggacgccct gaacgccggc gacgtcgacg gcgtgctggc cctgttcgcc
    13321 ccggatgcgg gcatgcgcac ggtgaccggc gagcacatcg ccggcgccga ggcactgcgt
    13381 gcggagatca gtggaaccgt tgccgcccgc ggcaggctga cgaacgtcag gcggcacacg
    13441 ctcgtcggcg cggaaacggc tctcctggtc accgactgga ccatggagat cgatggcccc
    13501 ggcggcgaac ggatcgcccc gaccggcacc accgccaaca tcgcccgcca atacgccgac
    13561 ggcggctggc gcttcaccgt cctcaacccg ctcggcaccg cctgagcctg agtcgtgcga
    13621 cgcgctgccg ctgccgggga gcctgagcag gcgcgcgaag cgcagcgggg gcgcgcaccg
    13681 ccccttctgc ttcctggttc gcgccgccaa cggcacgttt ttctacagct cgtcgcggac
    13741 gggcctgcct cctcatcggc agtagtcgca cttctcgcgt tgacgggtgg tcatggcggt
    13801 gaggcgttgg tagctggtga ggagatgtgt acagcacttt tctgtggtga attgggccgc
    13861 gtcgatgcgt gcttggccgg tgacgtgacc gttgtcgtcg agagctgcgc ggagggcgct
    13921 gagtagtgcg tcggggttgt cgggttggaa gaggtaggcg ttgtggccgt tggagaggac
    13981 gctggtgatg cctccgctgg aggggttgac cacagggatt ccggaggcca tcgcttcgac
    14041 gacggtgcag ccgaaggtct cgtaggggca ggctgtgcag aacgcatcgc aggaggcgta
    14101 gagggcgctg cggtcggcgc cacggacgaa gccgaggagg tggatccggg gtgaggccgc
    14161 ggccagttgt gtgatctggg cggtgatgtc ggacgggccg tcgccggcga tgaagagcga
    14221 gaggtcttcg ttgccgggca tggcgctcag cctgagaaag gccccgatga caaggtccag
    14281 gcgcttttca cgggcaagtc ggcccaggta gagcacgcgt ttgccgcggc cgtcgtaacg
    14341 aggcgccagc ttgtaaagga cggcagggtc ggcacggtcg gcgccgaaag agtcgatgtc
    14401 gacgctgtcg aagggaactt gctcgatccg cacgtcgctg aggccgccca aggtttcttc
    14461 agcgtagggg gtcgcgcaga tggcggtgtc gaagtgccgg tacacgtaac gcatgatggg
    14521 cgggaacatc gaggtcgcca ggtgccgcca gaccggatag ctgcgggcga agttgaagtg
    14581 gtcaccttgg tactgggcca cgtaaggcac gccgtgccgc cgtgcgtagg cgtgccccgg
    14641 tatcccccac gagccgaata cgaaggatcg ttcagggtcg atgacaacga ccaggtccgg
    14701 cgcgatcttt tccagcgcgc tgtcgatctg cgcgagtgcg gctcgacgcg ggacgcgcag
    14761 catcggatag ggcagccacg gcttggcggc gtaggggaac agctccagac cgggcgtgcc
    14821 cgccacggcc agggagctgc cgtcggtggg ttcggggacc agcaggcata aacgtacgtc
    14881 ctgctgcgcg gcgaaccact gggctcgcgc cacatttccc agcgagatgc cgctgacctc
    14941 aggtggaaag cttgcggtga tccaggctac ggtcatcggg gctgactcgg cacgcggaag
    15001 caactgaacg acctctccat caggattagg gctctccatg agcgcgttgt ccagcgggtc
    15061 ctcgaccgtg ccgacgttcg gggcggtacc ggcttgaagc tgtgatcggc caaggtcacc
    15121 tgacgacagt ggcagcggtc gatgaaaccc caatgaaacc ggggcctgac cgaactcaca
    15181 agagtgcccc gtccagggcg cccgcctcgt agcggggcag gcgcccggtg ttgccgctac
    15241 cggctccacc aacggcgcgg ctgcatgcgc gaccacgaac gcgtcccagc ccggcgcggt
    15301 ggccggatag tgcccgggcg ttaccaggtg acgtggagct gagtgggtcg gcgcaggatg
    15361 aggttggcgg ggcggggtgc cggggtccgg caagtgaggg tgaggccggg cagggttcgg
    15421 gtgaggactg cgagggcgtg gtgagcgacg aggcgggtgt actgggcacc ggggcagtag
    15481 tggatgccgg cgccgaagtt gagcgtaggg ggtgtgtcct cgcgacggtg gtcgaaggtg
    15541 tgggtggcgt ggacgctgtg ggcttcgtcg tgggcggcgg agtgcatgag gaggaggatg
    15601 cgggcgcctt gggggaggtc ggtgccggag agggcgacgg gtcgggtggt ggtgcggagc
    15661 cagccgatca ggggcgggtc caggcgcagg gtttcctcga cggctgccgg ggcctgttcg
    15721 gggtgctggg tgaggtggcc gtagccgtcg ccggtgagga ggtgctggag ggcggtggtg
    15781 gtgagcaggg cgagggtttc ggcgttggtg gtgaggacct ccatgagggt ggaggcgatc
    15841 tcggcgtcgg tcaggggggc accggcgtcg tcgcggtagg agatccacgt ggtggtgagg
    15901 tcgtcttgcg gtcggctgcg ccgctgggcg acgaggccgg tgcacaggtt ccacaggtcc
    15961 acgaccgctt gggcgcagcg ctgttgatcg gcgaggggct ggaaggacca caggaggtcg
    16021 gccatgccgg acgagccggc gatgacgcac tgttcgtcct cgggggcgat gccgatgagg
    16081 tcgctcatga tgcgtgcggt cagtgggcgt gcgtagtggg cggtgagttc gccggtgtgg
    16141 tcggggcggg cggcgagggc ttgcgcggct tgcagggcgc gcttttcgat gtgggagtgc
    16201 cagggggcga gctggttcgc gctggtgggc cataccgcgg tgagtgcgtc gcggtagcgg
    16261 gtgtgggtcg gggggtcggt ggaggcggcg acggggacgt cgtggacggc ggtgtagatg
    16321 cgggcggctt cggggtcggt gggctgaatg gggtcgtagc tgtgggcagg ggtgaaggcg
    16381 cggtgccggt cgcgcaggac ttcgtcgatg tcgcggtggc gggatacgac ccaaagatcg
    16441 aggtcggggt cgtggtagac ggggtgctcg cggcgcaggt gcgcgtaggc ggcgtggagg
    16501 tcgtcggctg cgtgtcgggc gatggcgcca ggggtgtggg ccgggcatcc gctgtgcgtg
    16561 gtcgtggtgg tggtcacgga ttcctcaatg agcgggcggg gcggtgggtc agctgtgggc
    16621 ggggtggcgc agcaggcagg ccaggtagcc cgtcttgtcg gtgaggaacg tgagtgtgtc
    16681 ggcgagggcg gtgtccatgg tgtcggcgta gggggtgccg aacttctccg cgatcagggc
    16741 gcggttgtcc tggtagatcc gcccgtatgc ctggcaggtg ggggcgatgt gctcgctcag
    16801 gtcgtgggtc tgttcgaggg tgagcccggc ggcgcggatc tggccgagaa cctggtcgtg
    16861 ggtgggcagg gggcagaagg cgaaggcgtc ccgacacatc gtcagctcgg cgtcggtggc
    16921 gggcacgcgc tgggtgtaga aggtgacgag catcgacgcg ccgggccggg ctgtccgggc
    16981 gagttcgcga agccccttca ccgggtcgtt gaggtggggg aagctgtcga gtgcccacac
    17041 ggcgtcgaag ctgccggtct cgtggggcag atccatggcg tcgccgaggc cgaagcggac
    17101 gcggtcggcc atccctgccg cggtggcgcg gcgggcagcc tcggtgagct gggcttggct
    17161 gatgctgcag ccggtgacct ggatgcggcg ctcgtgggcg gcgtggaggg cggggctgcc
    17221 gtggccgcag cccacgtcca gcagatgctc gcccggctcg atcgcgagca ggtcgcagaa
    17281 gaagtcggtc atccggttct gggcccgggt ggcgagctgc cgcgcaggca gcggctcgtc
    17341 gaggtcgccg ggctgccaca ggccgtagtg gaagctgtcg ccgctgatca tcttgcacaa
    17401 ctcgtcggag gcttcgtacc aggcggcgac ctccgccgag gtgaggaggg cggcgggtac
    17461 gacaggcgtg gaggtcatgc gtacgagtcc taacgggcgg tgcgggggcg ggcggtgagc
    17521 atcacggcgt cgtcgttgaa ccggtcggtg ccaccggcga agtgctcgcg cagggcgggc
    17581 agcagggcct cgcgcagttg tcccaggcgg gggtgtccgg tgttccagaa gtcggccagc
    17641 acctccgccg cggcgttggc cttgttctcg gggccctctt cggggaagac cacgtccacg
    17701 cgggcgcggg tgaagctgat gtcgtcgaag ccgtgctcgg ccaggacgcg ggcagcgagg
    17761 gtgagcaggt aaccctggtg gtcacggggc tcgccgatca ggggcgcgca agtgcggttc
    17821 cacagctcga tcagctcgtt gtcgggggcg ccctggacca gaacgatctt cgcttcgggg
    17881 tgcgcgcggt cgacggtccg ggccatctcc gcgaccgacg cctcggggtc atcggtgtag
    17941 tgcagtaccc aggtcgccac ggcggcgtcg aactgtgcat cgggcagggg gagttgttcg
    18001 gaacggcccg acagcacggt cactccgtgt gcggccagtg gccgcatgct ctcctcgcgt
    18061 gccgcgtgcg gctcgacggt ggtcaccgac cccaggcggg cggcgatctc gcggacgacc
    18121 gcgccggtgc cgcccccgac gtccagcacc cgggtgttgg ccgcgagtgc gtccacgacc
    18181 agcttgatgt cctggcgttc gaagcgggcc tccatgccca gccagccctg ctcgctcagc
    18241 tcgtgcggtc cacggtagga cgcgggcagc gggtaggggc cggccagcgt gtgggccggg
    18301 gcggcggggc ctccgggctt ggtggcgtac acgaacaggt gctcttcggg acccatgccg
    18361 gggaagtcgg ggtggaatac gctgagttgt tcgtgggcga tgtccaggcc ggccgtgcgc
    18421 agcagccgcc cgaacgtctc ggacgggtag ctggtgcagc ggacagtctg gcccatccac
    18481 tggatctcct cgtcctccgc gtcgaaaggc accgtcgcga ggacgaacag gccaccgggg
    18541 gcgagccagt cggcgatgcg ggcgagagtg gcgtccaggt cggcgcgcgg catctgcagc
    18601 agcgggaaga acgcggtgat cgcgtcccat tggccgggcg tctcgggcag ctcccggaca
    18661 tcggctagct cgaaccgggc cccggggacc tgtgtgcggg cgaggtcgac catggtctgc
    18721 gacacgtcgt accccgtgac ctggtgccct tgtgcggcga tcagatcggc ggtcggtcgg
    18781 ccggtaccgg agccgatgtc catcatcttc gccctcgcgg gcagccgggc caacagccag
    18841 tcgatcgccg cgagttgctc gggcaggtgg gcgtaggtgt cttcataggt cttgcccagg
    18901 acatcgaagg ggcgggccgc gcactgcccc gaacccggct gcgggaccgt agcgggaaga
    18961 gctgttgctt ccaaggtcat cgtacgagag ctcctgttcc tgacgggtgt gaccaccgca
    19021 cccggcgaga cactacactg cggaatcgat ccgtcgcgca cggtggtcaa tccgtgctga
    19081 tctcttccct ctgccatcag gtgcctttac caggagctga cctctcgcat gaccaccacc
    19141 atccccgaca gccacgccgc ctacttcgcc ttccgtgacc ggctcctggg cgaactgcgc
    19201 accaccgtcc tgaccggcga gcagctgtgc gaggccgggc gcctcatcta cggccgcgcc
    19261 gaagggcttt cgctgttcgg gatccccgcc cctcgaatgg agtcggccgg catccagctg
    19321 ctggggcgca ccgcgatcga gtgctgcgtc gacgactatg cctccgccgt cgccgacgcc
    19381 ctggccgacg tgcacgccac catccccgac gagggcgaag agccgctgat cgtggacctc
    19441 ttctgcggtt cggggaactt cagtcaccac ctcggcatcc gcctcggcac cgtcgtgcac
    19501 gccgccgaac tcgatccggg cgtccacgac gccacccggc acaaccttga gcgcatcgaa
    19561 gccgacaccc gcctccacct cggcgactac ggcgatctgc tcggcaaact ccttccccgc
    19621 ggcccgcgcg acacctactt cgtcgaaccc ccttgggggc cggccttcac ccccgccggt
    19681 ctcgacctca cccgcaccgc gcctcccgtc ccacggatcc tcgacgacat ccgccgttcc
    19741 cgaaacggcc gcccctgcct ggtcgcgatc aagaccaacg accagatcgc cgacaactcc
    19801 ctggccagat ccttcgtcgg cgcccgacac ctgcgcagca tcacaccgcg gcctgtgctg
    19861 cctcacggcg ccaacatgga cttccacctc taccggctgg agcaaggcgc cgacagctgc
    19921 ggcatgtgac aacggttgtc cgcactccga acccgcatcc gcgcggatgc agggcctgcc
    19981 cggtgggtcg cggccccgtc aggcgagtac caacctttcc tcgtcttcgc ggcagatgct
    20041 caccgccctc gacctcggct gcgaggtgaa ctactcggct tcaccgccgg cgctgtagcc
    20101 ccggagcagt gcgctcagga tgtcggtcag ccggggggcg acatcgacga cggcatgggc
    20161 gagacccggg tccgactcgt aaaggcggcg cagctcggtt cccggggcgg ccatctgcca
    20221 cagcgctccg gccatcgccg tggccgtggc gacgacgtcg ccggcctgcg ccgggctcag
    20281 cgcggcaacc cggcgcagcg cctcgcccac ggccgcgacc tcggcgatgg cggtcagctt
    20341 gaaggaccgg acgctctcca gcgagacgtt gcgctccagg ttcatcggcg tgtgggcgag
    20401 caggtcgcag aacaggggcc gcgccaccag cgactcggcc agcaggccgg cgaccgcctg
    20461 caggcgaggc tcccggtcca cgccgttcac ggcgtccgcg gagttctcgt cgtccgtgcc
    20521 gggcgccgcg tcggcgagct gcccgcgcac cgcctgcgac cactccaccc acccggcggc
    20581 agccaggcgg aggaagatct cttcccgggt ctcgaaatag cggagcatcg ccgacttgtg
    20641 catgccgacc tccgtggcga tatcggtcaa ggtcaccgat cggatgccgc tcaccgtggc
    20701 cagacgggcc gccgcggcga ggatcgtggc ctcgcgggcg cgcttggcct cggggctccg
    20761 ggctcttgtg gactgactgc ggctggccat acacgcatgc taacgcaacc atgttgcgct
    20821 attaccgcaa ccgtgtttcg ctatctgtat ggcaacccag acgtggttca tcaccggttc
    20881 ctcccgcggc ttcggccgct ccctcgcggt cgccgccctg gaggagggcg accaggtcgt
    20941 cgccactgcc cgcaggccgg aacagctcac cgacctggtc gagcggttcg gcgacaaggt
    21001 cctcccggtc gcgctcgacg tgaccgacgc cgccgcggcc gctgccgcgc tcgacgccgc
    21061 ccgtgaccgc ttcggccgca tcgacgtgat cgtcaacaac gccggctatg cgaacgtcgc
    21121 cccggtcgag acggctccgg aggacgactt ccgccgccag ttcgagacga acttctgggg
    21181 cgtgtaca
//
