LOCUS       NZ_CP031455            21738 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Streptomyces olivoreticuli subsp. olivoreticuli strain ATCC 31159
            chromosome, complete genome.
ACCESSION   NZ_CP031455
VERSION     NZ_CP031455.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces olivoreticuli subsp. olivoreticuli
  ORGANISM  Streptomyces olivoreticuli subsp. olivoreticuli
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Complete genome sequence of Streptomyces olivoreticuli ATCC 31159,
            producer of anticancer bestatin and diverse secondary metabolites
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8809793)
  AUTHORS   Zhang,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-2018) Tianjin Key Laboratory of Food
            Biotechnology, College of Biotechnology and Food Science, Tianjin
            University of Commerce, NO.409 Guangrong Road, Tianjin, Tianjin
            300134, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 29-JUN-2018
            Assembly Method                   :: SMRT Link v. 5.1.0
            Assembly Name                     :: TJCU_BT_311
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: SMRT Link v5.1.0
            Genome Coverage                   :: 145.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003391135.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 04:49:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,562
            CDSs (total)                      :: 7,459
            Genes (coding)                    :: 7,276
            CDSs (with protein)               :: 7,276
            Genes (RNA)                       :: 103
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 183
            CDSs (without protein)            :: 183
            Pseudo Genes (ambiguous residues) :: 0 of 183
            Pseudo Genes (frameshifted)       :: 61 of 183
            Pseudo Genes (incomplete)         :: 150 of 183
            Pseudo Genes (internal stop)      :: 18 of 183
            Pseudo Genes (multiple problems)  :: 41 of 183
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:12:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 369153
            Orig. end                         :: 390891
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Hongyu Zhang.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21738
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21738
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21738
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11738](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11738)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            312..1289
                     /locus_tag="DXZ73_RS01580"
     CDS             312..1289
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS01580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116209262.1"
                     /transl_table=11
                     /translation="MPNPPAPTKPDRDDLRTRALAAAGALSLAVGVLHLALPFYGGAGF
                     RYFGAGEHLARLADHQSPIPTVTMVGIAALLAVAAAYAWSAAGLLRLLPGLAPALTVIT
                     AIYLLRGLALLPEIPTRALSPTSLPLRELAFSGFALTTGLLHLAGLRAAASPLPARIRR
                     RLTPGKPPVCPGRVPRPTDAGQIPSLLETLMPDISTATSRRWPLWTAATIAAAIAALHL
                     FGGTPEFVGPLVHSNLDAPVKQLFRVLWHLCTLLLASLPVALAWAARADRRTARPLLAY
                     VWFIAAAFTGVFFAIDLDAFGSAVLTLPQWTLFIPLLILIPLAT"
     gene            complement(1818..2396)
                     /locus_tag="DXZ73_RS01585"
     CDS             complement(1818..2396)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS01585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_116209263.1"
                     /transl_table=11
                     /translation="MHQTAPAVPSPLRSHSENLDPRIAQFTSPATRILLAGDGLTTVLL
                     QAASQALLDIRTDAIEQTRANALGDTEAVSALHLQDQELCWLRHSRLLTPGGATISLNK
                     VVAPTARDPRLDAAMGDPERPLGFALSRAGLTTVRRLHNVGRARWPAGGDQLCAFKTYT
                     MHGPGGVLVFVHERYSPDWFSAAPDVPAG"
     gene            complement(2454..3224)
                     /locus_tag="DXZ73_RS01590"
     CDS             complement(2454..3224)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025217.4"
                     /locus_tag="DXZ73_RS01590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_116209264.1"
                     /transl_table=11
                     /translation="MRRRAGASGRHGLRIGPGQPRRAAGARCRVRLALSGHRSGDGTLS
                     HWLSWQVGARVTVVDRDTAFLQECSGELDVLQADITDPGFQPGQFDLVHARLVLMHVHE
                     REDLLPRMLSWLKPGGLLVLTDAVMLPGAQLLHPHYREAVTGHFRMMAEVIGSDLHFAN
                     RYPQAFAGLGLTATGTHAYQPVVGADHRFTEFVEGTLRQSRHFLLTNGMRPAALDEVLD
                     YVRRPDTRERFFELRTAWGRKPLPSPQGQYPDHP"
     gene            complement(3389..3697)
                     /locus_tag="DXZ73_RS01595"
     CDS             complement(3389..3697)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013068.4"
                     /locus_tag="DXZ73_RS01595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_162889953.1"
                     /transl_table=11
                     /translation="MTATGITEDGGRKVLGVMVGDSETEAFWTDFLRRLHERGLSGAVW
                     LLAGHDTGLVAAIRKVMISAAYRLSPAATSPKAAWMSSTPNSLKAPQLPNTTNTRTS"
     misc_feature    4006..4020
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     gene            complement(4152..5270)
                     /locus_tag="DXZ73_RS01600"
     CDS             complement(4152..5270)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013006246.1"
                     /locus_tag="DXZ73_RS01600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_162889954.1"
                     /transl_table=11
                     /translation="MRKNANRSTSRRVRAALSMAVAVCAVTALLPAAASAEPTAVAGGL
                     GAGVERVSVAADGTQADGNSAGASITSDGRHVVFSSSAKNLTPGGTTGGDRVYVRDQRT
                     GQIKQMGDLTPLQPPVISGDGEYVAYSLRWMKNVRVRQYEVSTGRTASADCWAYSCNQP
                     SLSANGHSIALAILIKQPSSPERQRIEVQDWNSGGVKVTVAELDHTSPSQPSISGDGRY
                     VAYQDGEAGDVFVWDRTSGTTSGPIEDSSAGATLVQLSNDGSKVVYLSGSDTYVYDVHS
                     GSAQLVPNARGVAIDPTGRYLLYAPNGTNGPSLTLRDLQTGTDEIVSNQPASAETNAVS
                     AGGHDVVFQSTAGDIVPGDTNGKSHIYVRHLF"
     gene            complement(5781..>6207)
                     /locus_tag="DXZ73_RS40245"
                     /pseudo=""
     CDS             complement(5781..>6207)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004993653.1"
                     /locus_tag="DXZ73_RS40245"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LIIGVVVLAASAHDNAAGTVLLDQAAERCGMRLEKALDQGFKDEV
                     VIRAARCWTLLSRPSAATGPTRAKTSSPAADAMGGRAGQRHVAAAPAPGPQIRPPPRQL
                     RLARLPGLHREHGPPPHHPCTGLA"
     gene            <6213..>6326
                     /locus_tag="DXZ73_RS01615"
                     /pseudo=""
     CDS             6213..>6326
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076612359.1"
                     /locus_tag="DXZ73_RS01615"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLIRTDRVAVDEPYYSMKHRHHGMNVQVLARPDGTPIW"
     gene            complement(7765..7983)
                     /locus_tag="DXZ73_RS01630"
     CDS             complement(7765..7983)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013068.4"
                     /locus_tag="DXZ73_RS01630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_240351075.1"
                     /transl_table=11
                     /translation="MRKFVYSTNLIESTNARLRKATRNLRHFPSEQAVLKVLHLAVREQ
                     IPPRSARYQPRRATLEEGAEPMIAEWG"
     misc_feature    7952..7966
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            complement(7987..8178)
                     /locus_tag="DXZ73_RS38690"
     CDS             complement(7987..8178)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS38690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_205519406.1"
                     /transl_table=11
                     /translation="MKTQFAHLVGPSAQPLVALSKAALAHGITQASIVLAAITTAGVIL
                     VPLWAPGRRPQLGNGAFL"
     misc_feature    8217..8230
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.2"
                     /tool="antismash"
     misc_feature    complement(8218..8231)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.03"
                     /tool="antismash"
     gene            complement(8267..9070)
                     /locus_tag="DXZ73_RS01635"
     CDS             complement(8267..9070)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003956345.1"
                     /locus_tag="DXZ73_RS01635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_116209268.1"
                     /transl_table=11
                     /translation="MTPDAGRSIRRSLLHSDAAAVMYREYHLLTRNRTNLLLAITPSAV
                     YLLLFATSLSRLIGHVQYGGQVIDYTEFAVPALLLSSMLAASTTVGTSLFQERLGRMDI
                     ELWSHPLRRSSYITGKILVSTVLILVQSLAALGVALMVFTFHWPAGHWAAVLCGTAVAS
                     MAFNGLYLLLASLFTDFQRFTVTINVVAPVLLFASPSFYPAAQMAPVLQWLSWANPVTY
                     GITCIRDGALFGFGEAWPWMFLLLSIAAITYLLIGHSLMARSAEL"
     misc_feature    complement(8987..8989)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9060..10004)
                     /locus_tag="DXZ73_RS01640"
     CDS             complement(9060..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014181616.1"
                     /locus_tag="DXZ73_RS01640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_116209269.1"
                     /transl_table=11
                     /translation="MNQAVQARNLVKRYKSMQRNAVDGLTFHIAAGAVIGLLGPNGAGK
                     TTLIKLICGVTVPSQGSVEVFGANPAAHGGAAKRGIGVVHQSGPFDMMLPAIDNLRIAA
                     RFKGLRWRDIRHRVDELLAAFGLDTAVSQLTFTLSGGELKRLQVIRALLGDPSLLLLDE
                     PSAGLDVNGRRQVWALLDELRRQYGTTVLWTSHYVEELERNCQQVLIVNHGRLVKFAAP
                     RDLAEQFGGHAALLSLARPHDTNRLAALLGQPELQVTVSGRRVEVSGRDVRALLPTLLT
                     AARALGIGIDTIEYRTPSLEDAFLELVGTGHDT"
     gene            complement(10001..10285)
                     /locus_tag="DXZ73_RS01645"
     CDS             complement(10001..10285)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="DXZ73_RS01645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family protein"
                     /protein_id="WP_162889955.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 6.5e-13,
                     bitscore: 47.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.4e-11, bitscore: 42.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYRIASDVVWIPDDGEVRLYDAGSGEFQALNTTAAEVWLLISEG
                     CPADDIAGEMARRYAGTATERQTQINLDVRKFLESLLKQGLVLADEGTA"
     aSDomain        complement(10025..10279)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DXZ73_RS01645_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.40E-15"
                     /identifier="RREFam002.1"
                     /label="DXZ73_RS01645"
                     /locus_tag="DXZ73_RS01645"
                     /protein_end="87"
                     /protein_start="2"
                     /score="47.3"
                     /tool="antismash"
                     /translation="YRIASDVVWIPDDGEVRLYDAGSGEFQALNTTAAEVWLLISEGCP
                     ADDIAGEMARRYAGTATERQTQINLDVRKFLESLLKQGLV"
     gene            complement(10308..11738)
                     /gene="stsB"
                     /locus_tag="DXZ73_RS01650"
     CDS             complement(10308..11738)
                     /codon_start=1
                     /gene="stsB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962676.1"
                     /locus_tag="DXZ73_RS01650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="StsB family radical SAM/SPASM domain sactipeptide
                     maturase"
                     /protein_id="WP_116209271.1"
                     /sec_met_domain="PTHR43273 (E-value: 3.6e-48, bitscore:
                     163.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.7e-24, bitscore: 85.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.3e-10, bitscore: 39.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.2e-08, bitscore: 32.0,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-14, bitscore:
                     53.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.2e-08, bitscore: 34.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLEQWDELVVPEDLVYFRNSEGHEGHLVTNPELAAWCLLTAPE
                     LKVLQALAQPGAGLPQGTAPAEAERTLARVILKFIVYLPGRRPKVRPPDPQLSTVYYAI
                     TDGCNLRCPYCYASSEKCLPGELSTEESLDLMDQIAAMGVRTVIFTGGEPMLRKDLFRV
                     AEYARGLGLAVNVISNGTLIRRPETARRISGIFHTVTVSMDGGTAETHEQTRGRGTFAR
                     TARGLRLLNDAGVIPTINHVVTPDNVDVLDKLCEFAADLKIRQVRLMYHSDLGRAASDE
                     YDFGWTEFQKIEEFIWTNPMAKNLLPDGPKGAKPCSIKGNCGMGGNEIYVNSLGDVYPC
                     KLVTKPLHRAGNVRHQRLADLFTSPLLENLRGSNVFSGENLRDCRHCYIRAACGGGCRA
                     YHMAETGDIHRNGRHLCRILRRSMITNWWVAAGATGRQLAEHRDEMFRPLLVRDDSVHP
                     VHEDWKTGGRRLLPIVPA"
     gene            complement(12596..13990)
                     /locus_tag="DXZ73_RS01660"
     CDS             complement(12596..13990)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF033550.5"
                     /locus_tag="DXZ73_RS01660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ISL3 family transposase"
                     /protein_id="WP_205519081.1"
                     /transl_table=11
                     /translation="MVNDTTLLLDLDGVSVIRVERCEDGGHRVHLATADVSARACPACG
                     VFASRVKGSATTRPRDLPYGERGLEFFWHKRRWFCREPTCPRASFTEQIPQIPAGARLT
                     GRLRSTAGHRIRDAGSTVIQAARDLRLSWPTVMDAFPAVAHEVVEAPLPEVGVLGIDET
                     RREQDLETGKWQLVRDRWHTGFVDALGVGGLLGQVEGRTVADVLAWLSTTPLTSRNNIR
                     HVAIDMSATYRAAIRTGLPNAVVVVDHFHIVQLANKMLSLVRRRTTAEIRGRRGRATDP
                     EWKARRRLLRNREDLTDEQFAKMWNPLLAEGKIGRTLLTAWIAKESLRNLLALARTGAN
                     RHQVDHARWKFLTWCADADIPEVRTLATTVDRWWPEIAAFIDSGHSNAKSEGINRVIKL
                     VARAAFGFRNAANQRLRTRCVTTRRARGHLRTAHLRRSANRAIPASVVAPPRTASRRRA
                     SMAPSR"
     gene            complement(14108..14362)
                     /locus_tag="DXZ73_RS01665"
     CDS             complement(14108..14362)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123990.1"
                     /locus_tag="DXZ73_RS01665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_116209273.1"
                     /transl_table=11
                     /translation="MLDPELLERITARRAELDELEEQPAKRLAEMRAEWDELAVAERVL
                     ERMSEQLADERASAEPMPGRQVQEFAGSSNLGGVCRHVR"
     gene            14711..15103
                     /locus_tag="DXZ73_RS01670"
     CDS             14711..15103
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DXZ73_RS01670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162889957.1"
                     /transl_table=11
                     /translation="MARGGRILAVLALSAMTLCGGRSAAYADGGKGAGNEDIVSGVLSV
                     VGSSTSTGHANQCGAPIGSVEVKSVCRARHDHADHDRSGSERVDSGLLSNVAAWNATGH
                     SNNCGNPNVAVFSDTTCITEDVHHGR"
     gene            complement(15113..16228)
                     /locus_tag="DXZ73_RS01675"
     CDS             complement(15113..16228)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016575794.1"
                     /locus_tag="DXZ73_RS01675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine protein kinase"
                     /protein_id="WP_240351076.1"
                     /transl_table=11
                     /translation="MKVGSWNEWDPLKHVVIGRADGTMVQAPEPAVVRDWPEHGFPRGT
                     YGSLPEEMTAAANEQLDGFARVLEERGIRVDRPRPLDFSRPVATPEWSQQSMFGAMPVR
                     DVLVVIGNELLEATMSFRSRWFEYLAHRPLIESYFRADPGMRWEAAPKPRLTEASYRPG
                     FWEEYDALLHEAQIARVRAGELVLTETEPLFDAADIARCGKDLFVQQSLATNAAGIRWL
                     RQHLPEHRVHGVTFGNAHPMHIDATWVPLRPGLVLHCAERPAEEELLHHLKVNDWQVVH
                     AATPGREAPPPLSACSRWLSMNVLVLDPATVCVEASETAQMEQLDRLGFEVVPMPFWNV
                     APFGGGLHCATLDVHREGVLEDYFPRRSGRF"
     gene            <16334..16597
                     /locus_tag="DXZ73_RS01680"
                     /pseudo=""
     CDS             <16334..16597
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013676.4"
                     /locus_tag="DXZ73_RS01680"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="Tn3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="AKDVLRRRLLLILFGLGTNMGIKRVAVTGKHGESEPTLRRVRHLF
                     VNRANMRAALRKLVNATFAVRDEMWWGTGTACASDNRKLGCR"
     gene            complement(16594..17460)
                     /locus_tag="DXZ73_RS01685"
     CDS             complement(16594..17460)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025079.4"
                     /locus_tag="DXZ73_RS01685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4158 domain-containing protein"
                     /protein_id="WP_116209276.1"
                     /transl_table=11
                     /translation="MGRDLGLDAVVEHFTLNVDELDWLRNKSGATRLGFAVQLKFLPFR
                     CRFPKTRIELPADAVAHAANQVGVPTADMALYDFTSRTAKRHRSEIRELTGRHECSVTD
                     QIKLASHLVDEIWHDERRPEQVRAELYRQMRQALSTLDTALPKLPWVTIDGKRKSGAIK
                     FTEPEPQKEPKNLGRLKKAIRKRPRSPGSRHARSVRSPPPGTAASRRCCRPHASACPPG
                     LLRALRVPSQGGSSSPISPQPTNEHRHTESVSPPPAQPRPEQTARNRALFEPKATGGLL
                     VAWSAAR"
     misc_feature    complement(16621..16623)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18241..19215
                     /locus_tag="DXZ73_RS01690"
     CDS             18241..19215
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016777.4"
                     /locus_tag="DXZ73_RS01690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_116215358.1"
                     /transl_table=11
                     /translation="MRNKIALEEHFGATDPDIVGQSEEHFTPETWPEARKQLLDINDIR
                     LRKMDALGIERNIVSLLAPGIQSMYDSKQAVDWAGRLNDHAAKQVAKHPDRFSSFAALP
                     MQDPDAACAELERCVTDLGFVGALVNGFSQVGDPGTAVYLDDRRYWPFWETVQRLDVPV
                     YLHPRDPLEDQQKIYEGHPWLLGSAWAFSVETGTHALRLMGSGLFDTYPKVQVILGHLG
                     ELLPYNIWRTDHRIPMSPRGIAVKQKFAHYLHHNFYVTTSGNFHTPSLADAIIEMGADR
                     ILFSTDYPFESMEEAANWYDAIELGEPNLQKIGRDNAVRLFKL"
     gene            complement(19377..19982)
                     /locus_tag="DXZ73_RS01695"
                     /pseudo=""
     CDS             complement(19377..19982)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828337.1"
                     /locus_tag="DXZ73_RS01695"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGGSRTARASTGGQKLDRQIDALKAAGCRKIFADKKSGKNDLRPE
                     LKACHAFLDAGDTLVVPALAATAGPSRT"
     gene            complement(20064..21656)
                     /gene="mdlC"
                     /locus_tag="DXZ73_RS01700"
     CDS             complement(20064..21656)
                     /EC_number="4.1.1.7"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mdlC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF005485.1"
                     /locus_tag="DXZ73_RS01700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="benzoylformate decarboxylase"
                     /protein_id="WP_205519082.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.4e-43, bitscore:
                     146.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.1e-29, bitscore:
                     100.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEAVFAVLRDFDVTRVFGNPGSTEMHMYLHWPDDLEYVLALQEG
                     SAVAMADGLAQRTGRAGVAIVHSAAGVGNALSGVIAAWRNQSPLVLLAGQQTRAMLPTE
                     PYLSALDADQFPRPYVKWAVQPARAADVPGAVARALLTALTPPCGPVFVSVPEDDWAEP
                     ATPVPAHTVVPVLGAEPAAIARFARVLADARHPALVLGPAVDGDGAALDAVRLAERLGA
                     AVYGAPWSSRASFPERHPLFQGYLTATREEVVRRLDGHDVVLVIGAQVFTYHVHTEGPF
                     LPAGAQYLHLTDNPVHAFSAPVGESLICSARTGIQALLDQLPDQRAHRTPLTAPPRPEP
                     APLAAPLEASAVLHLLRELVPAASPVFEEAPSYRQEIRAHFPMEASQYYNAFSGGLGWA
                     LPAAVGAALADPGRRTLCLIGDGSLMYSVQALWTAARHRLPLTVVVLNNSEYGAMKEFT
                     ALFGIDAFPPPIQSALDLPALDLVTLATGLGATANRADDPYRLPDTLTTALTAPGPTLV
                     DVPVQALRGTGPL"
ORIGIN
        1 atcgtcgctc gcgagggcct gcagaaaccc caactggaac cgtcgcactg ttcgcagcca
       61 cagcttcgcc aggagcaggt cgcgggagtc gaaccggtgg tagaccgagc ctaccggtgc
      121 cccgagggcc ccggcgacag ctgcgaccgt cgccgcgtcg ggccctccgg cggagaccaa
      181 ccgcagtgcg gcgtccagga actgatcctc ggtgaacttc gacgggcgac ccatgccacc
      241 aatggtaggc gacatgttct agaatccaga ttctagaact cttcctcgct ttcaggaggt
      301 gcagagacac catgcccaat ccgccggcac cgacgaagcc cgatcgagac gacctccgca
      361 cccgagccct cgcagccgcc ggcgcactga gcctggccgt cggcgtactg cacctcgcgc
      421 tgccgttcta cggcggcgct ggattccggt acttcggcgc cggcgaacac ctcgcccgcc
      481 tggcggacca tcagtcaccg atcccgaccg tgaccatggt cggcatagcc gcgctgctcg
      541 ccgtcgcggc ggcatacgcg tggtcggcgg ccgggctgct ccgcctgctg cccggactcg
      601 cgccggcact gacggtgatc accgcgatct atctgctccg cgggctcgcc ctgctccccg
      661 agatcccgac cagagcactc tcccccacat ctcttccact gcgagagctc gccttctccg
      721 gcttcgcgct gacaaccgga ctgctccatc tcgcaggact tcgcgccgcc gcctcgccgc
      781 tgcccgcacg gatacgccga cggcttaccc ctggcaagcc acccgtctgc ccgggccgag
      841 tgccacggcc gacagacgcc ggccagatcc catcacttct ggagaccctc atgcccgaca
      901 tcagcaccgc gacctcccgc cgatggccgc tctggacggc ggccaccatc gccgcggcga
      961 tcgccgccct ccacctgttc ggcggcaccc cggagttcgt cggccccctg gtccactcaa
     1021 acctcgacgc cccggtcaaa caactcttcc gcgtgctctg gcacctatgc accctgctac
     1081 tggcctcgct ccccgtggct ctggcctggg ccgcacgtgc cgaccgccga accgcgcggc
     1141 cacttctggc ttatgtctgg ttcatcgccg ccgcgttcac cggcgtattc ttcgccatcg
     1201 acctggacgc cttcggctca gcggtcctca ccctgccgca atggaccttg ttcatcccgc
     1261 tcctcatact gatcccgctg gccacctgag tgtccgtgaa caagctggtc cacagttttc
     1321 ggcgggtggg ccggttcagc gacagctgcg tgcagaagca gggcctcttg gtagtccagg
     1381 ggtgacgaaa ccatccggac gcacaagaag ccctgccatg ccgttgcaac ccctgtccgc
     1441 atctgccgtc atcccgtcga cggaatcgcc ctgttcctgc gtggcctgcc gctggaggca
     1501 cggaaccatc cgccgccgcg acgggcaccg tctgggcgcc tggctcgccc aggccgacga
     1561 atcccaggtc aaggaaacct gcaccttcac caacgggctc cgcaaaggac ctcgacgccg
     1621 tcaccgccgg cctcaccctc cccctgaact ccggcgccgt cgaaggcaac gtcacgagaa
     1681 tcgagctcct caaacgccag cacaacgccc gggtcggctt cggccttctc cggagacgca
     1741 tcctgctcgc gcgctgacca gccgcaggcc gcttcacgaa agctccgaag agccagagca
     1801 cgtccgttga cagtccatca gcctgccggg acgtcggggg ccgcagagaa ccagtcggga
     1861 ctgtacctct cgtgtacgaa gaccagtacg cccccggggc cgtgcatggt gtacgtcttg
     1921 aacgcacaga gctgatcgcc gcctgcgggc caccgggcac ggccgacgtt gtgcagtcgc
     1981 cgtactgtgg tgagcccggc ccggctcagt gcgaatccga ggggccgttc cgggtctccc
     2041 atggccgcgt ccaaacgggg gtcacgtgct gtcggcgcga cgaccttgtt gagtgaaatc
     2101 gtcgcaccgc ctggcgtgag caggcggctg tggcgcaacc agcacagctc ttgatcctgc
     2161 aggtgcagtg cggacaccgc ttcggtgtcg ccgagggcgt tcgcgcgggt ctgctcgatg
     2221 gcgtcggtgc ggatgtccag cagcgcttgt gacgcggctt ggaggagcac cgtggtcagg
     2281 ccgtctcctg ccagcagtat gcgggtggcc ggggaggtga attgtgcgat gcgtgggtcc
     2341 aggttctccg agtgggaacg aaggggtgag ggaacggcgg gggccgtctg gtgcacgagg
     2401 gcaaccttcg ctgggaggtg gggtgttcgt acgtcagggc tgtcggggat gcgtcagggg
     2461 tggtccgggt actgaccctg gggcgagggg agcggcttgc gtccccatgc cgtgcgcagt
     2521 tcgaaaaatc gctcccgggt gtcgggccgg cgcacgtagt cgagtacctc gtcgagcgcg
     2581 gccggccgca tgccgttggt gaggaggaag tgccgggact ggcgcagggt gccctcgacg
     2641 aactcggtga acctatggtc cgcgccgaca actggctggt acgcgtgtgt cccggtcgca
     2701 gtcagcccca aaccggcaaa cgcctgcggg taccggttcg cgaagtgcag gtcgctgccg
     2761 atcacctcgg ccatcatccg gaagtgccct gtcaccgctt cgcggtagtg cgggtgcagc
     2821 agctgcgctc cgggaagcat gacggcgtcg gtgagcacca gcagtccgcc cggcttgagc
     2881 caggagagca tccggggcag taggtcttca cgctcatgta catgcatcaa caccaggcgt
     2941 gcgtgcacca gatcgaactg gcccggctgg aatccaggat cggtgatatc cgcctggagc
     3001 acgtccagtt cgccggagca ttcttggagg aacgccgtgt cgcggtccac cacagtgacc
     3061 cgtgccccca cctgccagct cagccagtga ctgagggtgc cgtccccgct ccgatgtcca
     3121 gacagtgcca gccgcacccg acaccgagcc ccagcagcac gtcttggctg accgggtcca
     3181 atccgcaggc catgccgccc agacgctccc gctcgccgtc gcatccggag gagaacagca
     3241 catcgccata acgctgtgcg gatgagtcca ctgagtccac agtcatgccc cgaccaacga
     3301 tccaccagcg ccttcgtcac ctcaaacgca actgcagtac gcagtacaga gtgacgacgg
     3361 atcgtgtccc ttgtcgtggt gtaggggatc agctagtgcg cgtgttggtg gtgttgggta
     3421 gctggggcgc tttcagggag ttcggggtag agctcatcca tgccgccttc ggggacgtag
     3481 cggccgggga aagacggtag gcagcgctga tcatcacctt gcggatcgcg gcaaccagac
     3541 ccgtgtcatg accggcgagg agccagacgg ctccgctcag gccgcgttcg tgcaggcgac
     3601 gcaggaaatc ggtccagaat gcctcggtct cgctgtcgcc gaccatcacg ccgaggacct
     3661 tccggccgcc gtcctcggtg ataccagtgg cggtcaccac tgcacgggac ccattgcccg
     3721 cggcccgctc cggtccaggc cctggataat gctgaggcgg agccaccgcc gggtcccgga
     3781 ccgccggggt ggtgtgtcct gcccctctcg gtatgagggg caggacatac gcggcgtcag
     3841 ccgaattccg gcttcgacag tgtctcgttc gtacgcaggc gcaccaggga cagtagggcc
     3901 tgtcggaaac aaccggcctt gcgtcagcag gagttcagct cacatcttcg gggcgcagat
     3961 cagaccctga gacgtactcg gccaacccgt gcgggacgcc gagcatgacg agttcggcca
     4021 cgctcaccag tcgcctcctg gacccacagg accaccgatc gcttgaggac atcacgctcc
     4081 atcctcagcc gagccgggtt cccgagtggg accttcctcg gccgcctgct ccgttgcggg
     4141 tgccggggcg gtcagaagag gtggcggacg tagatgtgcg acttgccgtt ggtgtcgccg
     4201 ggcacgatgt cgccggccgt ggactggaag accacgtcgt gcccaccggc gctgaccgcg
     4261 ttggtctcgg ccgaggcggg ctggttcgag acgatctcgt cggtgcctgt ctgcaggtct
     4321 cgcagcgtga gcgacggtcc gttcgtgccg ttcggggcgt acagcagata gcggccggtg
     4381 ggatcgatgg ccacgccccg cgcattcggc accagttggg cggagcccga gtgcacgtcg
     4441 tagacgtagg tgtcggagcc cgagaggtag acgaccttgc tgccgtcgtt gctgagctgg
     4501 accagtgtcg cccccgcgga cgagtcctcg atcgggccgg aggtggtgcc gctggtccgg
     4561 tcccacacga agacgtcccc cgcctcgccg tcctggtaag cgacatagcg gccgtcgccg
     4621 ctgatggacg gctgggacgg ggaggtgtgg tcgagttcgg cgacggtcac cttgacgccg
     4681 ccgctgttcc agtcctgaac ctcgatgcgc tggcgctcgg gcgacgacgg ttgcttgatg
     4741 aggatggcca gggcgatgga gtggccgttc gcgctcagcg acggctggtt gcagctgtaa
     4801 gcccagcagt cggcggaagc cgtccttcca gtgctcacct cgtactggcg aacccgtacg
     4861 tttttcatcc accgcagcga ataggcgacg tattccccgt caccgctgat caccgggggc
     4921 tggagcgggg tcaggtcccc catctgcttg atctgccctg tccgctggtc gcggacgtac
     4981 acccggtcgc cccccgtcgt gccgccgggg gtgaggttct tcgccgacga cgagaagacg
     5041 acgtggcggc cgtcggacgt gatcgaggcg ccggccgagt tgccgtcggc ctgggtgccg
     5101 tcggccgcga cactgaccct ctcgacaccg gctccgagac cgcccgccac ggccgtgggc
     5161 tcggccgagg cggctgcggg cagcagcgcc gtgaccgcac agaccgcgac cgccatgctc
     5221 agggcggccc gcacacgtct gctggtgctc cggttcgcgt ttttcctcat tttcccccca
     5281 ggcaggacac gtctctcctc cagttcccca ctggaggacc gcagagatcc aaccgcgatg
     5341 gcgctacagg gtcaatgcgt acatgacata tcgagaggag cattccggcc atatgagagg
     5401 acattaaatc cgtttctggt agcggcctca tccgggttga gtgaggaagc cctggctggt
     5461 ggggcatccg aggcggctgc ggttgacgtt cagggcgggg tcgtcggtgg gcatgccgag
     5521 aagttcgtgc ggtcgcggac tctgaatgcc tggtcggggt gttggttaag acgttcacga
     5581 tggcctggta ggccgtgctg gactcggccg gatccggtga gtacccggtc gcctcgagtt
     5641 cggcgatgac cttccaggtg gtggccagat ccgcgagacg tgccccgatc ccggtgagag
     5701 agcggctgtg aagtagtcga tctggtcgcg cagttcaccg gcccgggtgg tggcctcatc
     5761 gcgccgcgcc tggagatccc tcaggagttc ggcgatgtcc acgcggccat cccgagggtg
     5821 tcacgccagg ccggtgcagg ggtggtgagg cggcggacca tgttcgcggt ggaggcccgg
     5881 tagacgcgcg aggcggagtt gtcggggcgg tggtcgtatc tgcgggccgg gcgccggtgc
     5941 agcagcaacg tgccgttgac ctgctcgacc acccatcgca tcggctgcag gggacgaagt
     6001 cttcgccctg gtcggcccgg ttgcggcgga cggcctcgac aacaatgtcc aacaacgcgc
     6061 cgcgcggatg accacttcgt ccttgaaacc ctggtccagg gctttctcca gacgcatccc
     6121 gcaccgttcg gcggcctggt cgagcagtac ggtgccggcg gcgttgtcat gtgcggaggc
     6181 ggccaggacg acgacgccga tgatcagccg acaccctgat caggacggat cgggtggccg
     6241 tcgacgagcc gtactactcg atgaagcacc gtcaccacgg catgaacgtc caagtcctgg
     6301 cgcggccgga cggcaccccg atctggttgc atgcgccact gccacttccg gggacagccc
     6361 aaagcccatc tgcaacacgt attcacggca atcgccgtga atatcgagcg gctcagcggc
     6421 ctgacagcag tcgaggaacc ccgctcacca cgaccgccga ccgccttcca gaacttcctg
     6481 gaccaacacg ggatcccccg cccccggaca aaatcctggc gaaccctcgg cagctgacct
     6541 cgaccgatcc gagattcccg tcagaatcaa gctcaactac actgatcgaa accgtataag
     6601 acatgttcag ggttcggagt tcaagaccca aaccgccctc actctcaaga gtaaaaacac
     6661 tcagtgaccc aaatagatcc gggcccacgg gcgagcctgg aatctggccg agatggggct
     6721 tcagaggcat cgaaaactgc tcgatatcac tgaacgggcc gcgctctaca ctgaaaagtc
     6781 aagacagttc atccaccata taacccgaga cttgcgatag accacagaat gagcacaaag
     6841 atccagtgac gaaaatcctc cttctccggg actggcggag agagctgcat ggagatcacc
     6901 ccgccgggcg accaaatcct catgcgcgag agcaacaaca ccggacgtgg tgactaccac
     6961 ccagcagggc acccttactg tgcccctcga tcgagcgaac gttggaaggt cgaccgtttc
     7021 atggagtgac gcacctccaa tccgccgacc acatcacctt ccttaccagt ttggggctta
     7081 gctttatgtc aaacagcaaa gatgcctcgc cgtcggctat gcatagcccc acattctccc
     7141 cctgcgccgc cgccccggac ggatcgtcag gcacggccac gccctggggt atcggccata
     7201 ccgcagccag agtgccacca gccgaggctt ctcacagctc acagcctcac aaatcaatgt
     7261 gtctaccagg gaaaacaggc tgtgagcctc ataactcaaa gccttccgac cacctctctc
     7321 aaccaggagc tccgccctgg ctgaagggag cgggggggcc gccgcgaccc accgcctggc
     7381 ggcaacagcc agtctccaga ggcaaccccg gccagccacc cgctccccca acagcaccga
     7441 cagcaccgta gaacggccga gtaccggctc gccctcagac agacaccaac tgatgggcac
     7501 agctgcgtta cgggccacct ttaatcgtct ccttcaacgg tccatgttct taggggtccg
     7561 cccatcgctc ttgctcttgg aagccatgga tacaccggag ggtttaatcg ccgaacactc
     7621 gaatgttggt tttcctctcc ccacgccgac gggtgctgcg gtgtctgaac ggtccactct
     7681 tcgcccggac cactagatct tgaaaatgca agcgcccgca atgacgaagt catcgatccc
     7741 ttacctgctg catcctcgaa cccgtcaacc ccactctgca atcattggtt cagcgccttc
     7801 ttccagcgtg gcgcgacgtg gttgatatcg cgcgcttcgg ggggggatct gctcacggac
     7861 ggcgagatgg aggaccttca acaccgcttg ctcggagggg aagtgcctaa ggtttcgggt
     7921 ggctttccgc agccgtgcgt tggtcgactc gatcagattc gtcgagtaga caaatttcct
     7981 catctcctac aggaaggccc cgttgcccag ttgaggacgc ctgccgggag cccacagggg
     8041 cacgagaatc actcctgccg tggtgatagc ggcgagcacg atcgacgcct gggtgatgcc
     8101 gtgggcgaga gccgccttgc tgagggcgac gagcggctgg gcggacgggc cgacgaggtg
     8161 ggcaaactgg gtcttcaaag ttgagcggtg cgcccgactt cacgtcctca cggctcgtca
     8221 cggtgcgtga ctgtgtggag ggttcagcga aggttgccca tgtccgtcag agttcggcag
     8281 aacgggccat cagggaatgc ccgatgagca gataggtgat cgcggcgatg cttaggagca
     8341 ggaacatcca gggccatgcc tcaccgaagc cgaaaagggc tccgtcgcgg atgcaggtga
     8401 tgccgtaggt gacggggttg gcccacgaca gccactggag tacgggtgcc atctgggctg
     8461 cgggatagaa ggacgggctg gcgaagagca gtacgggggc cacgacgttg atggtcactg
     8521 tgaagcgttg gaagtcggtg aacagcgagg cgagcagcag gtagaggccg ttgaaggcca
     8581 tagaggccac ggctgttccg cagaggaccg ccgcccagtg gccggctggc cagtggaagg
     8641 tgaacaccat cagcgccacg ccgagggctg ccaggctctg aaccaggatc agtaccgtgc
     8701 tgaccaggat ctttccggtg atgtagctgc tgcggcgcag tgggtgcgac cagagttcga
     8761 tgtccatccg gcccagacgt tcctggaaga gcgaggtgcc gacggtggtg gatgccgcaa
     8821 gcattgagga gagcagcagg gcgggcacgg cgaactcggt gtagtcgatg acctgcccgc
     8881 cgtactgcac gtgcccaatc agccgggaca gcgaggtcgc aaagagcagc aggtagaccg
     8941 cgcttggggt gatggccagc agtaggttgg tgcggttgcg ggtgagtaag tggtactcgc
     9001 ggtacatgac ggcggcggcg tcgctgtgca gcagggagcg tcgaatactt cggccggcat
     9061 caggtgtcat ggccggtccc cacgagttca aggaaggcgt cctccaggga cggggtgcgg
     9121 tattcgatcg tgtcgatgcc gatgcccagt gcccgcgcgg cggtgaggag tgtgggcagt
     9181 agggctcgta cgtcgcggcc gctcacctcg actcgtcgac cgctgacggt cacctgcagt
     9241 tcgggctgtc caagcagggc tgccaggcgg ttggtgtcgt gcgggcgggc caggctcagc
     9301 agtgcggcat ggccgccgaa ctgctcggcg aggtcgcgtg gggcggcaaa cttcaccagt
     9361 cggccgtggt tgacgatcaa tacctgctgg cagttgcgtt caagttcttc gacgtaatgg
     9421 ctggtccaca gcacggtagt gccatactgt cggcgcaatt cgtccagtag tgcccacact
     9481 tgccggcggc cgttgacgtc cagcccggcg gacggctcgt cgagcagcag gagtgaaggg
     9541 tcgccgagca gcgcccggat cacctgcaga cgtttcagtt cgccgccgga gagtgtgaag
     9601 gtcagctggg agacagccgt gtcgagtccg aacgcggcga gtagttcgtc cacgcggtga
     9661 cgtatgtccc gccatcgcag ccccttgaac cgggcggcga tgcgcaggtt gtcgattgcg
     9721 ggcagcatca tgtcgaaggg cccagactgg tggacgacgc cgatgccgcg tttggccgct
     9781 ccgccgtggg ccgcagggtt ggcgccgaac acctcgacgc tgccctggct ggggacggtg
     9841 acaccgcaga tcagcttgat cagtgtggtc tttcctgcgc cgttgggccc gagcagcccg
     9901 atgacggctc cggcagcgat gtgaaaagtc aggccgtcca cggcgttgcg ctgcatggac
     9961 ttgtagcgtt tgacaaggtt ccgtgcctgg accgcttggt tcatgccgtt ccctcgtcgg
    10021 ccagtacaag cccctgcttg aggagcgact ccaggaactt cctcacgtcc aggttgattt
    10081 gggtctgtcg ctcggtagcc gtaccggcgt agcggcgggc catctctccg gcgatgtcat
    10141 cggcggggca gccctcggag atgagtagcc acacttcggc cgcggtggtg ttgagagcct
    10201 ggaactcgcc cgagcctgcg tcgtacagcc gtacctcgcc gtcgtccggg atccatacaa
    10261 cgtcactggc tatccggtaa cgcatcagcg atcccccttc agtcagttca cgccggcacg
    10321 atcgggagga ggcggcggcc gcctgtcttc cagtcctcgt ggacgggatg gacactgtcg
    10381 tcgcgcacca gcaggggccg gaacatctca tcgcggtgct ccgcaagttg ccgtccggtc
    10441 gccccggctg ccacccacca gttggtgatc attgagcggc gcaggatccg gcagaggtgt
    10501 cggccgttgc gatggatgtc cccggtctcg gccatgtgat aggcgcggca gccgccaccg
    10561 caggcggcgc ggatgtaaca gtgacggcag tcccggagat tctcgccact gaatacgttg
    10621 cttccgcgca ggttttccag gagcggggag gtgaaaaggt cggcgagccg ctggtgccgg
    10681 acattgccgg ctctgtgcag gggcttggtg acgagcttgc atggatagac gtcgcccagt
    10741 gagttgacgt agatttcgtt gccgcccatg ccgcagtttc ctttgatgga acagggcttt
    10801 gcccctttcg ggccgtcagg cagcagattc ttggccatcg ggttcgtcca gatgaactct
    10861 tcgatcttct ggaactcggt ccagccgaag tcgtactcgt ccgaggcggc cctgccaagg
    10921 tcggagtgat acatcaaccg cacctgccgg atcttcagat cggccgcgaa ttcacagagc
    10981 ttgtccagca catcgacgtt gtcgggcgtc actacatgat tgatggtcgg gatgacaccg
    11041 gcatcgttca gcaggcgcag ccctcgggcc gtccgggcga aagtgcccct gccgcgcgtt
    11101 tgctcatgcg tctcagcggt accgccgtcc atgctcaccg tgaccgtgtg gaagatcccc
    11161 gaaatccgcc gcgcggtctc cggccgtcgg atcagagtgc cgttggagat cacattgacg
    11221 gccagtccca gcccgcgcgc gtactcggcc acccggaaga ggtccttgcg cagcatcggt
    11281 tctccgccgg tgaagatgac cgtccgtacg cccatcgcgg cgatctggtc catgaggtcc
    11341 agggattcct ccgtggacag ttcccccggc agacacttct ccgacgaggc gtagcagtac
    11401 ggacagcgga ggttgcagcc gtcggtgatc gcgtagtaga ccgtgctgag ctgcggatcg
    11461 ggcgggcgga cctttgggcg gcggccgggc aggtacacga tgaacttcag tatcaccctg
    11521 gccagggtcc gctcggcctc ggcgggggcg gttccttgcg gcaggcctgc tccgggctgg
    11581 gcgagtgctt ggaggacctt gagttctgga gcggtcagca ggcaccaggc ggccagttcc
    11641 ggattggtca ccaagtggcc ttcatggcct tcggagttac ggaagtacac caggtcttcg
    11701 gggacaacca gctcatccca ttgctccagc agcttcatcg accaccccaa caagatccca
    11761 atgagaagga aggcggggtt ccgaaccggg tcgaaacccc gcctgcggca tacagaaggc
    11821 agccaagcgt cagcttgcga gctcggactc gtcctcggcg ttgccggagc cggcgcctcc
    11881 gccgccggaa cagccgcatg agcaccgctg gtccggcgag aattcaatcg gaagaatttc
    11941 cggcttcacc catacgggtt ccttcatgat gtgcccttcc tctcggtggc cccagccgtc
    12001 accaggcacc gcagtgcttc acccggtgcg gccggacagc agacagcgag gtgctcgtca
    12061 cgctcgcaga tagcccgaac ggcaatgccc aatcgtgagg aaacaagaaa gctcgaagcg
    12121 atcaaaatgc gcgccggcca ggtcagccca gcgtgcatga atcgtcaggt cagtctctca
    12181 ccgggtcaac agggaggtag ttcttccgga attaccgctg aacggattcg gccagaacaa
    12241 cacagctctc tcgtcccgca gatacgcacc cagcccataa ttcgaccttc ctgaccgggc
    12301 ctggcggacg aggcgcgaca gacgtgttct cggccgacga gatcgggcgg tcgcgcatgt
    12361 gtacggtgat gcagacaggg cggatccctg tgacgatgaa cacgaccagc aacgatcaag
    12421 gtggtcgaag cctttgccca tgaatgaggg gcgcgttcgc atgccatcct cccttgtcag
    12481 agtcctgcgg cgccactgcc tggctaccgc ccccgccagc cgatctgccg gccctatcct
    12541 cgctggccca ggtgttggac cggatccccg gtccccaacg cgtgcggggc cgccgctacc
    12601 ggctgggggc catactcgct ctgcgcctgc tcgcagtcct cggcggcgcc acaacactgg
    12661 ccgggatcgc gcggttcgcg gatcttcgta ggtgagcggt gcggaggtgt ccgcgggctc
    12721 ggcgggtggt gacgcagcgt gtgcgtaggc gctggttggc agcgttgcgg aacccgaagg
    12781 cggcacgggc gacgagcttg atcacgcggt tgatgccctc gctcttggca ttgctgtgtc
    12841 cgctgtcgat gaacgcggcg atctcgggcc accagcggtc gaccgtggtg gcgagggtgc
    12901 ggacttcggg gatgtcggcg tccgcgcacc aggtgagaaa cttccatcgt gcgtggtcga
    12961 cttggtgccg gttggcgccg gtgcgggcca gggcgagaag gttgcgcagg gactccttgg
    13021 cgatccatgc ggtcagcagg gttcggccga tcttcccttc ggccagcagc gggttccaca
    13081 tcttcgcgaa ctgttcgtcg gtgaggtcct cgcggttgcg caggagtcgt cggcgggcct
    13141 tccactcggg gtcggtggcg cgtccgcgcc gaccccggat ttcggcggtg gtacggcgcc
    13201 ggaccaggga cagcatcttg ttcgcgagct gcacgatgtg gaagtggtcg accacgacga
    13261 cggcgttcgg caggccggtg cggatcgcgg cccggtaggt ggccgacatg tcgatggcca
    13321 catgccggat gttgttgcgc gaggtcaggg gcgtggtgga cagccaggcc agcacgtcgg
    13381 cgacggtgcg gccctcaacc tggccgagca agccaccgac accgagcgcg tcgacgaacc
    13441 cggtgtgcca ccggtcccgg accagctgcc acttgcccgt ttcaaggtcc tgctcccggc
    13501 gggtctcgtc gatgcccagc accccgacct cgggcagcgg cgcttcgacg acctcgtggg
    13561 caactgccgg gaaggcgtcc atcaccgtcg gccaggacag acgcagatcg cgggcggcct
    13621 ggatgactgt ggagccggca tcccgtatcc gatgtccggc cgtactccgt agcctcccgg
    13681 tcagccgggc gccggccggg atctgcggaa tctgctcggt gaacgatgcg cgaggacagg
    13741 tcggctcgcg gcagaaccag cgccgcttgt gccagaagaa ctccaacccg cgctccccat
    13801 aagggagatc acggggccgg gtggtggcgg atcctttcac ccgggacgcg aagaccccgc
    13861 aggccgggca ggcccgggcc gagacgtccg ctgtggccag gtggacccgg tggccaccgt
    13921 cctcgcaccg ctcgacccgt atgacggaca ccccgtcgag gtccagcagc aaggtcgtat
    13981 cgttgaccaa gcccgtggct ccccagtgat ccttctgcgt agagaacaga aatgatcacc
    14041 caggaccacg ggcgccttgc atccgggacc ggcaaccacc ccgactgtca cggattgtga
    14101 cagtcagtca gcgcacatgc cgacacacac cgcccaagtt cgaagacccg gcaaactcct
    14161 gcacctgccg cccgggcatc ggttccgccg aggcgcgttc gtcggcgagc tgctcactca
    14221 tccgctcaag gacccgttcg gctacggcga gttcgtccca ctcggcccgc atctccgcca
    14281 gccgcttggc cggctgttct tcgagttcgt ccagttccgc gcgccgcgcg gtgatccgtt
    14341 ccagcagctc gggatccagc atgcaccgga tcgtagaagg cctccggcca cagcgagcag
    14401 gaaccggcga gccaatgtcg gcggccaagg tcttttccca cgtatggcag cccattcccc
    14461 acctgcggcc cccgcgcggc cggttgtgct ccccgctcag gagccgacgg atgcgctcag
    14521 tgcgcgcctt atggacaccg ctggccaccg cgccgggtga gtgacgtggg gaccggtggg
    14581 tgatcgtcgc tgctggcgga aggagctcac gcagtggcgt gtcttttcgg atcttcggag
    14641 gttagtgcaa gcggaccgcg cagggcggtc cgcttggctc agggatgctc gaggaaagag
    14701 gcggttaccc atggctcgtg gcggcaggat cctggccgta ctggcacttt cggcaatgac
    14761 cctgtgcgga ggcagaagcg ccgcctatgc ggacgggggc aagggcgcgg gcaatgagga
    14821 catcgtcagt ggtgtcctgt cggtggtggg cagcagcacc agcacggggc acgccaatca
    14881 gtgtggagca cctatcggca gcgtggaagt gaagtcggtc tgtcgggcca ggcacgatca
    14941 tgccgaccat gaccggtcgg gcagcgagcg ggtggacagt gggctgctgt ccaatgtcgc
    15001 cgcctggaac gcgaccggtc acagcaacaa ctgcggaaac ccgaacgtcg ccgtgttcag
    15061 cgacaccacc tgcatcaccg aggacgtgca ccacggccgc tgaccctcgg cctcagaacc
    15121 tgccggaccg ccggggaaag tagtcctcca gcacgccttc acgatggacg tcgagcgtgg
    15181 cgcagtgcag tccgcccccg aagggggcca cgttccagaa cggcatcggg acgacttcga
    15241 agcccagccg gtcgagctgc tccatctgtg cggtctcgct cgcttccacg cagacggttg
    15301 cggggtccaa taccagcacg ttcatcgaca gccagcggct gcatgcggac agcggtggtg
    15361 gtgcctcccg gccgggggtg gctgcgtgga cgacctgcca gtcgttgact ttgagatggt
    15421 gcagcagctc ctcctcggcg ggccgctcgg cgcagtgcag aaccagtccc ggacggagcg
    15481 gcacccaggt ggcgtcgatg tgcatggggt gcgcgttgcc gaacgtcact ccgtgcacac
    15541 ggtgctccgg caggtgctgt cgtagccagc ggatcccggc cgcgttcgtg gcgagggact
    15601 gctggacgaa caggtccttg ccgcagcggg cgatgtcggc ggcatcgaaa agcggctcgg
    15661 tctcggtcag caccagctcc ccggccctga cccgggcaat ctgcgcctcg tgcagcaggg
    15721 cgtcgtactc ctcccagaag cccggccggt acgacgcctc ggtcagccgg ggtttggggg
    15781 ccgcctccca gcgcatgccg gggtcggcgc ggaagtagga ctcgatcaac ggccggtgag
    15841 ccaggtactc gaaccagcga ctgcgaaacg acatggtcgc ctcaagcagc tcgttcccga
    15901 tcaccaccag gacgtcccgg accggcatgg caccgaacat gctctgctgc gaccactcag
    15961 gggtggcgac cggccgactg aagtccaacg gccggggccg gtcgacgcgg atcccgcgct
    16021 cttcgaggac gcgggcaaag ccgtccaact gctcgttcgc ggcagccgtc atctcctcgg
    16081 gcaacgaccc gtacgtaccg cgcggaaaac cgtgctccgg ccagtcccgg acgaccgccg
    16141 gctcgggagc ctgcaccatg gtgccgtccg cccggccgat gacgacatgc ttcagcggat
    16201 cccactcgtt ccaggaaccg accttcaccg aacctccccc tggtttccgc ccggtgcggc
    16261 ccactgcccg aagtaggcag cagcgcaagg caagtctgac gtctgcccgg ccgcagcacg
    16321 agaggacaag gcggcgaagg acgtgctgcg gcgccgacta ctgctgatcc tgttcgggct
    16381 gggcacgaac atggggatca agcgggtcgc ggtaaccggc aagcacggcg agagcgagcc
    16441 gacgctgcgg cgggtgcggc acctgttcgt caaccgcgcc aacatgcgcg cggccttgcg
    16501 caagctggtg aacgccacct tcgccgtccg ggatgagatg tggtggggca ccggcaccgc
    16561 gtgcgcctcc gacaaccgca agttggggtg ccgttaacga gcagccgacc aagcgacaag
    16621 taacccgccg gtagccttcg gttcgaagag ggctctgtta cgggcggttt gctcgggtct
    16681 gggctgtgcg ggtggtgggc tcacactctc ggtgtggcgg tgttcgttgg tcggctgggg
    16741 gctgatcggc gaggaggaac cgccttggga cgggacgcga agcgcgcgaa gcaggcctgg
    16801 agggcaagcg gaagcgtgcg gccgacaaca gcgccgggat gccgccgttc ccgggggcgg
    16861 agatcgaacg gatctggcat gcctggaacc gggcgatcgc ggccgcttgc ggatcgcctt
    16921 cttcagacgc cccagattct tcggctcctt ttgcggctcc ggctcggtga acttgatcgc
    16981 cccgctcttg cgcttgccgt cgatggtcac ccacggcagc ttcggcaggg ccgtgtccag
    17041 cgtggacagg gcctggcgca tctgccggta cagctcggcc cggacctgct cgggccggcg
    17101 ctcgtcgtgc cagatctcgt cgaccagatg ggaggcgagc ttgatctggt cggtgaccga
    17161 gcactcgtgc cggccggtca gctccctgat ctcgctgcgg tgccgcttgg ccgtacggga
    17221 ggtgaagtcg tacagcgcca tgtctgccgt tgggacaccg acctggttgg ccgcgtgggc
    17281 gaccgcgtcc gcgggcagct cgatgcgggt cttggggaag cggcaccgga agggcaggaa
    17341 cttcagctgg acggcgaagc ccaggcgggt ggccccgctc ttgttccgca gccagtccag
    17401 ctcgtcgacg ttcagcgtga agtgctcgac caccgcgtcc agcccaagat cccgccccac
    17461 cgggcccgcc cctttctccg tgccgtccga cgcacccggg gtcggcggcg ggttaccgcc
    17521 ggtgtgccgt gtgcggtgtt cactcgttca gctcaatgag gtgatccact tccgggcaac
    17581 gggcggacat gatcagagat gaagggggcc cttcttcccg gtcgcgaccg ggccgtcccc
    17641 tgccagccga gcgtgtctgt gctggtcagt gggccgacgg tgctgtgtac cggcgagttc
    17701 ggtgtaacgc cttcgcgtag gggcttgcgg gacctgcgcg cgcggtgtgc ggcgatgcgg
    17761 caggccggcc ggtcgaagac ggcgtcgcgg cggtgtccgc ggcctggcag gaagcggcgg
    17821 ccgcacacgg ggcagcgcac agcgatcgca tcggggccgt tgaggatcat gtacagcccg
    17881 atcgcggctc ccgcgcccca gcggcgccgg tcgcgtcgtg cccggcccgt acatgagagg
    17941 ccgcagtaga tcgcctccga gcgggcagcc gcccggatcg gctctcggta ccaccggcac
    18001 cggcgcactc gaccgtcatg gattcagtgc cccatttgtg agcccgacat gacaggccag
    18061 tctgtcatct gtcacgtgga cagcgaatga tcgccgtcca ccgtgcaggc ggcgctaccg
    18121 tgccggacgc cgtcgagcag cgggcggggc gattactgat cggttgcggc atccgctcgg
    18181 ctgtagacac cataggaaag tccggagggg gactgcgttg cgcttctcaa ggtggtcatg
    18241 atgcggaaca agatcgctct cgaagagcac ttcggcgcca ccgacccgga catcgtgggc
    18301 cagtccgaag aacacttcac ccccgagacc tggccggaag cccgcaagca gctgctggac
    18361 atcaacgaca tccggctgcg gaagatggat gccctgggca tcgagcggaa catcgtctcc
    18421 ctcctcgcgc cgggtatcca gagcatgtac gacagcaagc aggccgtcga ctgggccggc
    18481 cgcctcaacg accacgccgc caagcaagtc gccaagcacc ccgaccggtt ctccagcttt
    18541 gccgcactgc cgatgcagga cccggacgcg gcctgcgccg agctggaacg ctgcgtgacc
    18601 gacctcggct tcgtcggcgc cctggtcaac ggcttctccc aggtcggcga ccccggcacc
    18661 gcggtctacc tggacgacag gcggtactgg cccttctggg agaccgtcca gcgcctcgac
    18721 gtccccgtct acctgcaccc gcgggacccg ctggaggacc agcagaaaat ctacgaagga
    18781 cacccctggc tcctcggctc cgcctgggcc ttctccgtgg agaccggcac ccacgccctg
    18841 cgcctgatgg gcagcggact gttcgacacc taccccaagg tccaggtcat ccttggccac
    18901 ctaggcgaac tcctgccgta caacatctgg cggaccgacc accgcatccc gatgtccccg
    18961 cgcgggatcg cggtgaaaca gaagttcgcg cactacctcc accacaactt ctacgtcacc
    19021 accagcggca acttccacac accgtcactc gcggacgcca tcatcgaaat gggcgccgac
    19081 cgcatcctct tctccaccga ctaccccttc gaatccatgg aagaagcagc gaactggtac
    19141 gacgccatcg aactcggcga acccaacctc cagaaaatcg gccgggacaa cgccgtacgc
    19201 ctgttcaagc tgtgagccgg aaccgggctc agggcttggt ctctgcggtc ggccggacga
    19261 cgtgcggttc ctggacctgc gcagatcagg cggctcgcgc caggcagtac ggggtgatgt
    19321 cgcagcgcgt ggccgacagg gcaagcgccc tcccttggcc cggtggtacc cggggatcac
    19381 cggttgccgc cttcgagctg cgcggggatg cggctggccc gcagctcacg caggtccggg
    19441 atgtggttgt agagcgtgcc cggggagacg ccgagcatct tggcgatcgc ggtgatggag
    19501 tgctcggggt tgggcagcag gtcccgggcc atgttgagga tcttctcgtc gaccacggtg
    19561 ggccggccgc cgaccttgcc gcgggcgcgg gcggcggcca ggccctcgcg ggtgccggag
    19621 acgatgagtt cgcggatgaa ctccgccagg gccggcgaag acgtggaaga cgagccggcc
    19681 gccggggatg gtggtgtcca ggttttcgtg cagcgaggtg aagccgatct cgcggcggcg
    19741 gagctcggcc accatgttga tcaggtcctg gagggaccag ccgtagcggc cagggcgggg
    19801 accacgaggg tgtccccggc gtcgagaaag gcgtggcatg ccttgagttc gggacggagg
    19861 tcgttcttgc cggacttctt gtccgcaaag atcttccggc acccggccgc cttcagggcg
    19921 tcgatctgcc ggtcgagttt ctgtccgccg gtggacgcgc gtgcggttct tgaaccaccc
    19981 aggtttttga aggagttttt gaaggctccg ggcggcccgc gacggcctgt ccggcggtct
    20041 tcattaaacg tttcttgaag gggtcacagg gggccggtgc cgcgcagggc ctgtaccggg
    20101 acatcgacga gagtggggcc gggggcggtg agagcggtgg tgagggtgtc gggcaggcgg
    20161 tacgggtcgt cggcgcggtt cgcggtggcg ccgaggccgg tggcgagggt caccagatcg
    20221 agggcgggca ggtcgagggc ggactggatc ggcggcggga aggcatcgat gccgaagagg
    20281 gcggtgaatt ccttcatcgc gccgtactcg ctgttgttga ggacgacgac ggtgaggggc
    20341 agccggtggc gggcggcggt ccacagggcc tggaccgagt acatgaggga gccgtcgccg
    20401 atgagacaca gggtgcggcg gccggggtcg gccagggcgg cgccgacggc ggcgggcagg
    20461 gcccagccca ggcccccgct gaaggcgttg tagtactggc tggcttccat cgggaagtgg
    20521 gcgcggatct cctgccggta ggaaggcgcc tcctcgaaca ccgggctggc ggccggcacc
    20581 agctcgcgca gcaggtgcag gacggcggac gcctcaagcg gtgcggccag gggggcgggc
    20641 tcggggcgcg gaggcgcggt gaggggtgtg cggtgggcac gctggtcggg cagttgatcg
    20701 aggagggcct ggatgccagt gcgggcggag cagatcaggc tctccccgac cggggcggag
    20761 aacgcgtgca cgggattgtc ggtcaggtgc aggtactggg caccggcggg caggaagggg
    20821 ccctcggtgt gaacgtggta ggtgaagacc tgggcgccga tgacgaggac gacgtcatgc
    20881 ccgtcgaggc gccggaccac ttcctcgcgg gtcgcggtga ggtagccctg aaagagggga
    20941 tggcgttcgg ggaagctggc ccgagagctc cagggggcac cgtagacggc ggcgccgagg
    21001 cgctcggcca gccgtaccgc gtcgagggcg gcgccgtcgc cgtccacagc ggggcccagc
    21061 accagggccg gatgccgggc gtcggcgagg actcgggcaa aacgggcgat ggcggccggt
    21121 tcggcgccca gcaccgggac gaccgtgtgg gccggcaccg gcgtggccgg ctcggcccag
    21181 tcgtcctcgg ggacggagac gaacaccggc ccgcacggcg gggtgagcgc ggtcagcagg
    21241 gcacgtgcga cggcaccggg gacatcggcg gcacgggcgg gctggacggc ccacttcaca
    21301 tacgggcggg gaaactggtc cgcatcaagc gcggacagat acggctcggt gggcagcatg
    21361 gcccgcgtct gctgtccggc cagcagcacc agcggactct ggtttcgcca cgcggcgatc
    21421 acgccggaca gcgcgttgcc cacaccggcc gccgagtgca cgatcgcgac cccggcccgg
    21481 ccggtacgct gcgccagacc gtcggccatc gccaccgcgc tgccctcctg gagcgccagg
    21541 acgtactcca gatcgtcggg ccaatgcagg tacatgtgca tctcggtgga gcccggattg
    21601 ccgaacaccc gtgtgacatc gaagtcgcgc agtaccgcga aaaccgcctc ggccacgctc
    21661 ggtccgtcag cgcgggcatc cgcaggagcc atgaaagacc tctctcgtga ccccggcacc
    21721 agcatgagca acgcgagc
//
