LOCUS       NZ_CP031320            22808 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces armeniacus strain ATCC 15676 chromosome.
ACCESSION   NZ_CP031320
VERSION     NZ_CP031320.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces armeniacus
  ORGANISM  Streptomyces armeniacus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8083249)
  AUTHORS   Labana,P., Gosse,J.T. and Boddy,C.N.
  TITLE     Draft genome of the type strain Streptomyces armeniacus ATCC 15676
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8083249)
  AUTHORS   Labana,P., Gosse,J.T. and Boddy,C.N.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-JUL-2018) Department Of Chemistry and Biomolecular
            Sciences, University Of Ottawa, D'Iorio Hall, 10 Marie Curie,
            Ottawa, Ontario K1N 6N5, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUL-2018
            Assembly Method                   :: SPAdes v. JULY-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 65.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003355155.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:13:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,031
            CDSs (total)                      :: 6,963
            Genes (coding)                    :: 6,742
            CDSs (with protein)               :: 6,742
            Genes (RNA)                       :: 68
            rRNAs                             :: 6, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 36 of 221
            Pseudo Genes (incomplete)         :: 204 of 221
            Pseudo Genes (internal stop)      :: 5 of 221
            Pseudo Genes (multiple problems)  :: 22 of 221
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:36:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6264820
            Orig. end                         :: 6287628
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031320.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22808
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="26"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22808
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22808
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12808](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12808
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            complement(925..2850)
                     /locus_tag="DVA86_RS27190"
                     /old_locus_tag="DVA86_27370"
     CDS             complement(925..2850)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018089111.1"
                     /locus_tag="DVA86_RS27190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27370"
                     /product="DUF87 domain-containing protein"
                     /protein_id="WP_208882231.1"
                     /transl_table=11
                     /translation="MKRARARRSAPPARRHPAAEAVQPDNSPALTPDTLAVGARHLEVG
                     GELVASFAVTGFPREVHPGWLQPLLTYPGRVDVSLHVEPIDPVTAARRLKRQLAKLESG
                     RRYREERGRLLDQYVEAATEDAYDLSARVARGEGKLFRLGLYLTVHAASRQELETEVAA
                     VRALAASLLLDAKPTSYRSLQGWVTCLPLGLDQVRMRRTFDTSALAAAFPFTSPDLPPA
                     DPTTVAAAPAGVLYGYNTASQGLVHWDRFALDNHNSVILGHSGAGKSYLLKLELLRSLY
                     RGIEIHVIDPEDEYARLTHAVGGTYLHLGADGVRLNPFDLPLYTREDGRRTAPKDALVR
                     RALFLHTVISVLLGTGLTPAERAVLDRAITLTYQQAGITSDPRTWTRPAPLLADLASVL
                     EESKTRAANDLAARLDPYVRGAFSGLFNGPTTTRPEGHLVAYSLRDLAEELKPIGTLLT
                     LDTVWRQVSNPALRRPRLVAVDEAWLLMKEPAGADFLFRMAKGFRKRWAGLTVATQDTA
                     DVLGSELGKAVVANAATQILLRQAPQAIDEITATFNLSEGEREFLLAADRGQGLLAAGT
                     QRVSFEAIASPAEHHLITTDPAELAAYAEHGATAAGTESYLDLDSGSDVHTFDADPDDS
                     VDLDAR"
     gene            complement(2847..3971)
                     /locus_tag="DVA86_RS27195"
                     /old_locus_tag="DVA86_27375"
     CDS             complement(2847..3971)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024078.4"
                     /locus_tag="DVA86_RS27195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27375"
                     /product="PrgI family protein"
                     /protein_id="WP_208882233.1"
                     /transl_table=11
                     /translation="MTQSIRIPADVDREDTVLANLTARQLTILAVTGIVLYGIWSATRS
                     LVPLPVFAVAALPVGAGAALLALGRRDGLSLDRLMTSALRQRLAPRFQVAAPEGLHPAP
                     AWLTGKATPAHGEDYPGGDVHPAPVRMPAEQVTETAAVDLGGDGLAAVAVCSTVNFALR
                     TPTEQQALTGAFGRYLHSLTAPVQVLVRTERLDLSAQINELRANASQLPHSALEAAARE
                     HADYLVQLGQQTDLLRRQVLLVLREPLHTAVPVDGLGGTSLLSALTPCKRTRRSAQPDD
                     ATLHAAQTRLARRLGEAVELLGPSGITVTPLDPGQATAVLAAACNPDSLLPPSPSLAAA
                     DDVITTPPPVEYGSRDGGAEESWLSGMPEGRSAS"
     misc_feature    complement(4082..4093)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.97"
                     /tool="antismash"
     gene            4294..5364
                     /locus_tag="DVA86_RS27200"
                     /old_locus_tag="DVA86_27385"
     CDS             4294..5364
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029688.1"
                     /locus_tag="DVA86_RS27200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27385"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_208882235.1"
                     /transl_table=11
                     /translation="MPRPIARVLALLELLQSGGIRTAAELADRLGVDERTVRHYIGHLI
                     DLDIPVESVRGRHGGYRLAPGHRMPPLMLNDDEALAVALGLVAGERAGLTPSTSTGTGT
                     GAGTSTGAGASTNTGTGTASETAAAKIRRVLPGRLRLRLDAVLGSLAFTAPPRTPAAAP
                     ATEVLLPIADAVNHHRPVTIRYTSADGRHSERTLHPHGLVVHSGKWYTTAADLTSGQDR
                     TFRLDRITDVRTLPGSFEPPPAADPAERVLTALATAPYRYEVSLRVQATAEHIHTRLPP
                     SVAVVHELPSPGGADAQTERWSRVGLRVDRLDWLPAVLASLDRPFVIDRPDELRGLVEA
                     LAERLTASARRTPPQD"
     gene            5578..6513
                     /locus_tag="DVA86_RS27205"
                     /old_locus_tag="DVA86_27390"
     CDS             5578..6513
                     /NRPS_PKS="Domain: PKS_ER (15-308). E-value: 3.1e-31.
                     Score: 100.6. Matches aSDomain:
                     nrpspksdomains_DVA86_RS27205_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507393.1"
                     /locus_tag="DVA86_RS27205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27390"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_208882237.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.7e-19, bitscore:
                     68.8, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRALVVDHGEAGPVRFADADEPEPSSDEALVEIRHIGLNFGELNY
                     VHQWPAGTVHGHDAAGVVVRAASDGSGPPEGTRVAVGMSPHAWAERVAVRPASLGTVPE
                     GVDLADGAALGIAGVTALRVLRKRSLLARDVLVTGASGGVGHFAVQLAALAGARVTALV
                     GSPDRAAGLRELGADRVLTDPADLTGLTGPAETERRFDLVLDTVGGPLLAQAWDSLAEG
                     GTIHLVGYSSGQDTTFPSGALFGFGEPRSIATYGDMTPTGGELTDLLDLMAAGRLSAPV
                     GLRGHWRDVDDAVQALFARKVHGKIVLDVV"
     aSDomain        5623..6501
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DVA86_RS27205_PKS_ER.1"
                     /evalue="3.10E-31"
                     /label="DVA86_RS27205_PKS_ER.1"
                     /locus_tag="DVA86_RS27205"
                     /protein_end="308"
                     /protein_start="15"
                     /score="100.6"
                     /tool="antismash"
                     /translation="FADADEPEPSSDEALVEIRHIGLNFGELNYVHQWPAGTVHGHDAA
                     GVVVRAASDGSGPPEGTRVAVGMSPHAWAERVAVRPASLGTVPEGVDLADGAALGIAGV
                     TALRVLRKRSLLARDVLVTGASGGVGHFAVQLAALAGARVTALVGSPDRAAGLRELGAD
                     RVLTDPADLTGLTGPAETERRFDLVLDTVGGPLLAQAWDSLAEGGTIHLVGYSSGQDTT
                     FPSGALFGFGEPRSIATYGDMTPTGGELTDLLDLMAAGRLSAPVGLRGHWRDVDDAVQA
                     LFARKVHGKIVL"
     CDS_motif       5746..5778
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DVA86_RS27205_0001"
                     /evalue="1.10E+01"
                     /label="PKSI-ER_m5"
                     /locus_tag="DVA86_RS27205"
                     /protein_end="67"
                     /protein_start="56"
                     /score="-0.8"
                     /tool="antismash"
                     /translation="HDAAGVVVRAA"
     CDS_motif       5980..6033
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DVA86_RS27205_0002"
                     /evalue="5.40E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="DVA86_RS27205"
                     /protein_end="152"
                     /protein_start="134"
                     /score="15.8"
                     /tool="antismash"
                     /translation="VLVTGASGGVGHFAVQLA"
     gene            6538..7458
                     /locus_tag="DVA86_RS27210"
                     /old_locus_tag="DVA86_27395"
     CDS             6538..7458
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016473183.1"
                     /locus_tag="DVA86_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27395"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_208882239.1"
                     /transl_table=11
                     /translation="MDVLAEALRVSGARGALGVVLKAGGAWGLWLDSYPGGALHVVSRG
                     TVWLHVPGGKPVEVRAGEAVMVSPGTAHGIASGASTTMGSCDREATDRALTEGSALHLG
                     SAPAQTEVLVLHYEQDPEVSTPVLTSLARPMHITSRENAQLGKTVELLTAELAHPQTGT
                     TAAAVNSIVDLLLIQFVRVWLARHPEMRSGSWLGATRDPVVRDALACVHARPEHPWTTE
                     SLAAATAVSRTTLSRHFRSALGQTPGAYVTQWRMDLASVRLRDTDEPVESISGAVGYAS
                     PHAFSRAFRRARGMPPGEYRSRLRG"
     gene            complement(7874..8182)
                     /locus_tag="DVA86_RS27215"
                     /old_locus_tag="DVA86_27405"
     CDS             complement(7874..8182)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056316.1"
                     /locus_tag="DVA86_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27405"
                     /product="transcriptional regulator"
                     /protein_id="WP_208882241.1"
                     /transl_table=11
                     /translation="MTAAKFDELIHPSTRLSLVATLAAADWAEFAFLRDRLGLSDSALS
                     KQLATLEEAGYVATERRISGSRRKVRARLTPAGREAFDGHIAALQAIVDAAHPADGL"
     gene            complement(8179..8640)
                     /locus_tag="DVA86_RS27220"
                     /old_locus_tag="DVA86_27410"
     CDS             complement(8179..8640)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018840265.1"
                     /locus_tag="DVA86_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27410"
                     /product="hypothetical protein"
                     /protein_id="WP_208882243.1"
                     /transl_table=11
                     /translation="MDAIASEQARASLDAAEHARRQVTEEIGLPPGYWWAMAAGWLVLG
                     ACGAVLPWLAGIAAGLFGAGHAVFASRLLTGRRRTRQIQVSASVAGRRIPVVVVGMLLG
                     LVAVTVLAALALDADGAGHASIWAGGLMAVVIGFGGPDILRVLRGWARA"
     gene            9021..9734
                     /locus_tag="DVA86_RS27225"
                     /old_locus_tag="DVA86_27415"
     CDS             9021..9734
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837020.1"
                     /locus_tag="DVA86_RS27225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27415"
                     /product="response regulator transcription factor"
                     /protein_id="WP_245997234.1"
                     /transl_table=11
                     /translation="MVDEQALFRAGIRHLLSDAEGFELAGEAESAERALHLLQELSPAP
                     DVVLIDPRSEAGAGTVAIRALRSEPAPPDGAVNGADGGNGANGANGVRGGRAPRALAVS
                     VQDDDDSVMAALRAGASGYITKQTSERELLRAIEIVAEGGAVFSPVIAKRLNEYFSTPH
                     TASCRSMFPQLTGRETQVLDLLARGWSNGRIAKDLVLTEKTVRNYVSQILVKLDVHHRA
                     EAVVRAREAGLGVLS"
     gene            10001..12808
                     /gene="lanL"
                     /locus_tag="DVA86_RS27230"
                     /old_locus_tag="DVA86_27420"
     CDS             10001..12808
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="DVA86_RS27230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27420"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_208882247.1"
                     /sec_met_domain="Pkinase (E-value: 1.9e-18, bitscore: 65.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8.2e-37, bitscore:
                     125.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSETQQPGHLYVDDFLAVRDETVALHGWHHSADDMWCHVLPPGH
                     CSRPQGWKIHLSATPRSAVPVLQGAARVLLERGVAFKFAKGAAQLRQLLSVRCHRGSSG
                     KFLTVYPESDRQFAELVEELHQATDGMPGPKILSDRRYRPGSLVHYRYGGFTSRQQVLG
                     TDGSYVPMLVAPDGSWYQDEREAWYAPVPWSAPPLPDEAPAPARGDGERGKQRVLLDSR
                     FAVFEAIRHSNRGGVYRAKDERTARTVVIKEARPYVAAESDGTDARDYLRNEHEILRLF
                     EGMGIAPRPVSLFEYQDHVFLAEEEIPGVTLRAWVDRHVRDDPGRLVSLDAVLPVARRL
                     VDLVATVHGKGLVFRDLTPNNVMVTPDGELVLIDTEFVTRPGEQVTRVMTMGYVAPEEM
                     SGPARHPAPGQETDLYSLGASLFHLSTGIHPLLAEDSSPEPRPLDGRVASLVEAVAGTS
                     PTLRALAPLVLGLLRQDPRQRIGLTRVRELLASTAAREHDDGSAAPVRLPAGEQQRLLD
                     DSVRELVAAMTPDDERTLWPAFPYGGRQSDPLSLQAGCAGSIDALRRTLALGATGECAG
                     TDGPGSNGTDGAAGAAGADAVRGALRTSVTWLEARLRQDQRLLPGLFFGRAGTCWALYE
                     AAEALGDEDAMRRAVERAKRLPVAWANPDVTHGVAGSGLAQLHLWRRTGDDELARRVAI
                     CAESAQAARPSGGSTQWRLADSPGGRSAGGPTHLGYAHGVAGICTFLMAAARELDRPEL
                     LTTAAEGGDYLLCVAREQGDGATWPVSPPQPGDEEPQEGVCWWCSGASGIGTFLIRLWR
                     ATGEARYREAAHRAAVATRAEKWFLSANHCHGIAGNAEFLLDMAAATGERVYRDWAEEY
                     ATCLARLCVLRDGRLVPVDEASLRTTYSYGLGLAGSLGFLHRLRHGGERWWMVDDFALA
                     PEGLR"
     gene            complement(13246..14025)
                     /locus_tag="DVA86_RS27235"
                     /old_locus_tag="DVA86_27425"
     CDS             complement(13246..14025)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016825801.1"
                     /locus_tag="DVA86_RS27235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27425"
                     /product="hypothetical protein"
                     /protein_id="WP_208882249.1"
                     /transl_table=11
                     /translation="MLRTHARKTVLTTVALVATTAMMTACQDSSSDSDSKKSKGSSSSE
                     QETGGGDSASDNDGTQANSAEKPGKKGGKGVSGTWFGTVSYLAPGKYTVTDMKDQKQQF
                     FTSTTTNIQGAGDICGDENGQAATKCTEAQLEAAAKKGVSAKVQIKNGTAVSIIDDRSG
                     GGDNSGGDKGVSGTWFGTVSYLAPGKYTVSDMKGKEQAFFTSTTTNIQGAGEICGDENG
                     QAATKCSETELEAAAKKGVSAKVQIKDGTAVSVIEDR"
     misc_feature    complement(14196..14205)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     misc_feature    complement(14275..14290)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            14283..14924
                     /locus_tag="DVA86_RS27240"
                     /old_locus_tag="DVA86_27430"
     CDS             14283..14924
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017946124.1"
                     /locus_tag="DVA86_RS27240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27430"
                     /product="LysE family translocator"
                     /protein_id="WP_208882260.1"
                     /transl_table=11
                     /translation="MVPTDRLLAFAVASFLLIVVPGPSVLFVVGRALAQGRRAALTTVV
                     GNTVGAYVLVAAVALGVGSVVERSALVFTALKLAGGAYLVFLGVRAVRQRGSLQAAFAG
                     EGPAAQGGLRTFWEGFAVGVANPKTIVFFAAVLPQFVDRGAGHVAAQMLVLGLVFNAIA
                     LASDSVWGLAAATARNWFARSPRRLAVIGGAGGLTMIGLGVSVAATGRND"
     gene            complement(15034..15723)
                     /locus_tag="DVA86_RS27245"
                     /old_locus_tag="DVA86_27435"
     CDS             complement(15034..15723)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662605.1"
                     /locus_tag="DVA86_RS27245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27435"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_208882262.1"
                     /transl_table=11
                     /translation="MTRAQAPANAARRGRPPKGATRLSRESIVDATLRVIDAEGVGAVG
                     MRSVARLLGVDAKSLYNHVHGKDGLLDAVAEHLLSGMEIPARTGDVRLDLRAIADAFRD
                     RALRHPEAAALTLTRQLASLEGLAPTEALLSVLRDAGCPLEESVHLLRVFVATLVGTLL
                     REVHAGQAFGVGDSAVAARRQTLERSGLPRTAEAAPHLARFDRYAEYEYTVGTAIELML
                     SRASRPG"
     gene            15881..16450
                     /locus_tag="DVA86_RS27250"
                     /old_locus_tag="DVA86_27440"
     CDS             15881..16450
                     /GO_process="GO:0030638 - polyketide metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662607.1"
                     /locus_tag="DVA86_RS27250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27440"
                     /product="ester cyclase"
                     /protein_id="WP_208882264.1"
                     /sec_met_domain="PF07366 (E-value: 2.2e-13, bitscore: 48.8,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLPPRFTLPPEDVLRAREKLVLDHFRDEVRQDWDATLSTFPHPR
                     YELIAPMQVHDGDGEVRAYYHDTRVAFPDQHHELIALRHSADAVIVEFWLLGTHNGPLG
                     AIPPTGSTHRTRMTAYFVFDEHENLVTERIYFDQLTILGQLVGGLDKRKPTGLLKLARV
                     LKGAMSKSGGKPDPRLLGTTPPDLTG"
     gene            16519..17109
                     /locus_tag="DVA86_RS27255"
                     /old_locus_tag="DVA86_27445"
     CDS             16519..17109
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536891.1"
                     /locus_tag="DVA86_RS27255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27445"
                     /product="isochorismatase family protein"
                     /protein_id="WP_208882266.1"
                     /transl_table=11
                     /translation="MTAALAPPLPPAPVQALIVVDVQTAFVTGTAAVPGAARLLPRVED
                     LVARARTAGSLVVHLQNDGPPGADDEPDTPGWELYLPVAESPRETALRKTEDDGFAGTP
                     LGGLLDAAGVRDLAVCGVMSEMCVSATARTALARGHRVVVPHDAHATQNIPAAPGISGP
                     VPAAMVSRVAEWALGDGAEIAAHAADVAFAPPG"
     gene            complement(17127..18134)
                     /locus_tag="DVA86_RS27260"
                     /old_locus_tag="DVA86_27450"
     CDS             complement(17127..18134)
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015995.4"
                     /locus_tag="DVA86_RS27260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27450"
                     /product="glycine betaine ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_222623373.1"
                     /transl_table=11
                     /translation="MRTPRTTPRRLAVLLALAAALAVPALSGCSGAAGDTGSVGARELR
                     GGSLAKDFDLDGAEFTVGSKEFTEQKILGKIMIYALRAAGARTADQTGLNGSAIVRGAL
                     KSGDVDMYWEYSGTGWTQFLGHDRPVQGSKRQYEATAREDAEKHGIEWLGPARFGNQYA
                     IARAGDADGPVGEVEKLSDLKRLGEEHPDELTLCGASEFLDREIRALQKTYGVSFPSPQ
                     VYQNALALNYVNVAKGSPCRLAEVFTTDARLESLDLKVLTDDKGHFTTELAALTLREDT
                     LRKHPELRELAERLGRELTKETVIDLNAMVDLDGRTPDEAALRFLRENGFIAKG"
     gene            complement(18170..18985)
                     /locus_tag="DVA86_RS27265"
                     /old_locus_tag="DVA86_27455"
     CDS             complement(18170..18985)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952933.1"
                     /locus_tag="DVA86_RS27265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27455"
                     /product="ABC transporter permease"
                     /protein_id="WP_208882268.1"
                     /transl_table=11
                     /translation="MPASTSTAPAPAPTPAPVSAPTRAPARPRRAALLRYALTPLGLGV
                     VLLVLALHVSSQQRDLIEERSLNSEYLVSRTVKHLELTAVVTVLILVIAIPLGVLLTRR
                     WARRIAGPVLAVASIGQALPSLGLIVLLAVAFVSLGVNQIAVIAFVAYGILPVLRNTIA
                     GLQQVDRSVIEAAEGMGMTRGAVLWRIELPLAVPVMLAGVRTALVITVGTVALATFIGA
                     GGLGDVISNGISSSRNLVLVTGSVLVAVLALFIDWLAGMAEDFLRPRGL"
     gene            complement(18991..20175)
                     /locus_tag="DVA86_RS27270"
                     /old_locus_tag="DVA86_27460"
     CDS             complement(18991..20175)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009085673.1"
                     /locus_tag="DVA86_RS27270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27460"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_208882270.1"
                     /transl_table=11
                     /translation="MTEKTPDANANAHVDPMIRLDRLTKRYPGQSEAAVDELTLDIPEG
                     RIVTFVGPSGCGKTTTMKLINRLIEPTSGRIHLDGKDVTEVPAHLLRRRIGYTIQQGGL
                     FPHRTVADNIATVPRLLGWDKQRVTARVDELLRLVGLDPDTYRRRYPKQLSGGQQQRVG
                     VARALGGDPQVMLMDEPFGAIDPLNRESLQNEFLRIQAEVRKTIVFVTHDIDEAVRMGD
                     LIAIFADNGKVLQYDTPERILADPADGFVSDFIGAGASVRRLSLTRMDSLELPAWPTVA
                     ESADGEQRRTAAARTERDHLLVLDDDDRPTSWLPVTGAGREVGGALPLLRALGPGDSLF
                     DALDHMLAANSSVLAVVDGDGRYRGVVEMDSLRALINTVHGRGRTDGSDQLQEA"
     gene            complement(20178..20825)
                     /locus_tag="DVA86_RS27275"
                     /old_locus_tag="DVA86_27465"
     CDS             complement(20178..20825)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576397.1"
                     /locus_tag="DVA86_RS27275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27465"
                     /product="ABC transporter permease"
                     /protein_id="WP_208882272.1"
                     /transl_table=11
                     /translation="MNFFEFLQGNWTDVLDATVAHALLVLQGLGLAVLIGVPVSVLTYR
                     TGAPRAAVLAVAGLLLTIPSYALFGLLITPLGLGSGPSVVALTLYALLPVVRNTIVGLR
                     ELDPAVVESARAMGMGRARVLATVELPLAWPVLLTGLRVATQLLLGIAAIAAAVNGPGL
                     GNLILDGLATAGTPFAIYLTIEGAAGIVLLAVLFDLAYAVVNRLTTPKGLGA"
     gene            complement(20843..21844)
                     /locus_tag="DVA86_RS27280"
                     /old_locus_tag="DVA86_27470"
     CDS             complement(20843..21844)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (33-166). E-value:
                     4.2e-13. Score: 41.4. Matches aSDomain:
                     nrpspksdomains_DVA86_RS27280_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="DVA86_RS27280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27470"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_208882274.1"
                     /sec_met_domain="PF00561 (E-value: 2.3e-09, bitscore: 35.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.2e-15, bitscore:
                     56.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTHAFPFFSSGLRLDADLHLPDDNGAGAPYPVVIPASGYQGLKV
                     IHPERFARALTARGYAVVAFDYRGFGTSEGERGRLVPQEWAEDLRAAVDRAAAAELLDA
                     GRIALLGWGMGGGVVVAEAADDLRVRAVASVNCISDGTRSTRNMHDEATWNSLLERIAG
                     DRGRRAERGRSEITSPWDIVRLDRDGRTDGYVGEELYKAPGFGSGVSLESAEMLLRFSP
                     QSVVHRIAPRPLLVVHGAENGLHLPEEARALYEHAREPKRLHLIEGAGHTEWMFDEHPT
                     FRALVEELDAFYAEAFAHGPAAQPVPAPAAAPHASAPASAPAPAPAPATANA"
     aSDomain        complement(21347..21745)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DVA86_RS27280_Abhydrolase_1.1"
                     /evalue="4.20E-13"
                     /label="DVA86_RS27280_Abhydrolase_1.1"
                     /locus_tag="DVA86_RS27280"
                     /protein_end="166"
                     /protein_start="33"
                     /score="41.4"
                     /tool="antismash"
                     /translation="VIPASGYQGLKVIHPERFARALTARGYAVVAFDYRGFGTSEGERG
                     RLVPQEWAEDLRAAVDRAAAAELLDAGRIALLGWGMGGGVVVAEAADDLRVRAVASVNC
                     ISDGTRSTRNMHDEATWNSLLERIAGDRG"
     gene            complement(22001..22783)
                     /locus_tag="DVA86_RS27285"
                     /old_locus_tag="DVA86_27475"
     CDS             complement(22001..22783)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013757.4"
                     /locus_tag="DVA86_RS27285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_27475"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_208882275.1"
                     /transl_table=11
                     /translation="MATDSSSSLHRTLAILTALGSDEAAERGGLGVVEIARRVGREKTQ
                     VSRALKALDQVGLVERDRDSLVYRLGWRVFTMAVNAGRPRLLAEAPPVLRSLVNVLKER
                     VHLTVLTEDGALTVLSESPMRAVQATGWVGRVTPLHTTSSGRALLFDHSDDEVRALLAD
                     TPFGAGEPAAPRDAEDFLARLQRARERGYVLVQEEFEAGLVAAAAPVRDFRGRVVAALN
                     VSGPTYRMGSELDRAGRVVCSAARQVSRAMAGQQQATA"
ORIGIN
        1 ttcttccgtg acctgcggac ggtcgttggt gagcagccgc agcggggggc ggcgcccgtg
       61 cagccgttcg tggcgttcgg cgtcgacttc ggcctgccag gaacggaacg tgcgtccatc
      121 gaggcgtttg aggtagtgcg ggatgcggtt ggcggggata ccgaccagcc ggggcccgag
      181 tacggcgagg aggtcgtttg cttcctggct gtgccacccc gcttcggtga tggcctcttc
      241 gtcggggaag acgtcggcga cccggtcgtg ttcgggatcc agcgcgctgt catggatgcc
      301 gccgtagctg tacacccata ggaggttctc cggggcttgt ggttccacca gggcgcggaa
      361 gcgggcgact tccttggtgt aggcgtagaa gttcacctcg gggcgggcgc agatgatccg
      421 gagccaggcg aaggtgtagg cgtcggagaa gaagtcgccc gagtcatgga tccgtatcca
      481 ggcgccgcgg aacttcgcgg cgcccagttc ggtggtcatt gcgtcttccc agccgggcag
      541 gtcgtccagg acgaaggcga ggttggcttg gtgtttggcc cgaacgacgg gccaggtgta
      601 ggtgccgtgc cgggcgtagc agacctggcg gcagaccccg gccgaggggc aggtgttgta
      661 gctgcggcca tcaggcaggc ggccggccca ggcgggcagc gaccagttcc agacaccgat
      721 ggcgcgcatc tcacggttct gggtcagcag gcgggttggt cgcggcgatg gggtggaccc
      781 ggatggagtg gaggacatga gggtgccctt caagcggtgc gagcggcggt ccattgcctg
      841 tcgtggggtt cgaagacgcg cacgcggacg gcgtgttgcc gtggagccgt cccctggtga
      901 gctgtggccc cgagttcgga gggctcagcg ggcgtcgaga tcgacggagt catcggggtc
      961 ggcgtcgaag gtgtgcacgt cactgccgga atcaagatcc agatatgact cggtaccggc
     1021 cgcggtggcg ccgtgttcgg cgtaggcggc gagttcagcg ggatcggtgg tgatcaggtg
     1081 gtgttctgcc ggtgaggcga tcgcttcgaa ggagacgcgc tgggttccgg ccgccagcag
     1141 cccttggccg cggtcggcgg ccagcaggaa ctcccgctct ccctcggaca ggttgaacgt
     1201 ggcggtgatc tcgtcgatgg cctgcggggc ctggcgcagc aggatctgtg tggccgcgtt
     1261 ggccacgacg gctttcccga gctcggagcc gaggacgtcg gcggtgtcct gggtggcgac
     1321 ggtaagtccg gcccagcgtt tccggaaacc tttggccatg cggaagagaa agtcggcacc
     1381 tgcgggctcc ttcatcaaca gccaggcctc gtcgactgcg accaagcggg gccgccgcag
     1441 ggcggggttg gagacctgcc gccagaccgt gtccagggtc agcagggtgc cgatcggctt
     1501 cagttcctcg gcgagatccc tcagggagta ggcgaccagg tggccctcgg ggcgggtggt
     1561 ggtggggccg ttgaagaggc cggagaacgc gccgcgaacg taggggtcca agcgtgcggc
     1621 gaggtcgttg gccgcgcggg tcttggactc ttccaggacc gaggcgaggt cggcgagcag
     1681 cggggcgggg cgggtccagg tgcgcgggtc ggaggtgatg cccgcttgct ggtaggtgag
     1741 agtgatagcc cggtccagta cggcccgctc ggcgggggtg agcccggtgc ccagcaggac
     1801 cgagatgacg gtgtgcagga acagggcacg gcgcaccagg gcgtccttgg gcgcggtgcg
     1861 gcgcccgtcc tcacgggtgt acaggggcag gtcgaagggg ttgaggcgta caccgtcggc
     1921 gccgaggtgg aggtaggtgc cgcccaccgc gtgggtgagg cgggcgtact cgtcttcagg
     1981 gtcgatgacg tggatttcga tcccccggta cagggagcgc agcagttcca gcttgaggag
     2041 gtaggacttg ccggcgccgg agtggccgag gatgacgctg ttgtggttgt ccagggcgaa
     2101 gcggtcccag tggaccaggc cctgggaggc ggtgttgtag ccgtagagca ccccggccgg
     2161 ggcagcggcc accgtggtgg ggtcggcggg gggaaggtcg gggctggtga aggggaaggc
     2221 cgcggccagc gcgctggtgt cgaaggtgcg gcgcatccgt acctggtcca ggcccagcgg
     2281 caggcaggtg acccagcctt gcaggctgcg gtagctggtc ggtttcgcat cgagcaggag
     2341 gctggcggca agcgcgcgga cggcggcgac ctcggtctcc aactcctgac ggctggccgc
     2401 gtgcacggtc aggtacaggc cgagacggaa gagcttgcct tcgccgcggg cgacgcgggc
     2461 tgagaggtcg taggcgtcct cggtggcggc ctccacgtac tggtcgagga gccgccctct
     2521 ctcctcgcgg tagcggcgcc cggactccag cttggccagt tgccgcttga ggcgccgggc
     2581 tgcggtgacc gggtcgatcg gctcgacgtg caaggagacg tcgacgcgtc cggggtaggt
     2641 cagcagcggc tgcagccacc cgggatggac ctcgcgggga aagccggtga cggcgaacga
     2701 ggccaccagc tcgcccccga cctccaggtg ccgggcaccc acggccaacg tgtccggggt
     2761 cagcgcaggg ctgttgtccg gctgcaccgc ctccgccgcg gggtggcggc gcgcaggcgg
     2821 tgctgaccgg cgggcacgtg cacgcttcat gacgcagacc tcccttctgg catgccggag
     2881 agccagctct cttcagcgcc gccgtcccgg ctcccgtact cgaccggggg cggggtggtg
     2941 atcacgtcat cggcggcggc gagggacggg gagggcggca gcaggctgtc ggggttgcag
     3001 gccgctgcca acacggcggt ggcctgcccg ggatccagcg gggtgacggt gatcccgctg
     3061 gggcccagga gttcgacggc ttcgccgaga cggcgtgcca ggcgagtctg cgccgcgtgg
     3121 agagtggcgt catccggctg cgcgctccgc cgcgtgcgct tgcacggagt gagggcggag
     3181 agcagcgagg tgccgccgag cccgtccacc ggaacggccg tgtgcagggg ttcacgcagt
     3241 acgaggagga cttgacggcg cagcagatcg gtctgctggc ccagttggac aaggtagtcg
     3301 gcgtgctcgc gcgcagcggc ctcgagcgcc gagtgcggca gctgtgacgc gttggcgcgc
     3361 agttcgttga tctgcgcgga cagatcgagt cgttcggtgc gcaccaggac ttggacgggg
     3421 gcggtcaggg agtgcaggta gcgtccgaac gcgccggtca gcgcctgctg ttcggtgggg
     3481 gtgcgcaggg cgaagttgac ggtgctgcac accgcgaccg ccgcgagccc gtcgccgccc
     3541 agatccaccg cggcggtctc ggtgacctgc tctgccggca ttcgtacggg agcggggtgg
     3601 acgtcgccac cgggatagtc ctccccgtgt gcgggtgtgg ccttcccggt gagccaggcg
     3661 ggggcggggt ggaggccttc gggggcggcg acctggaagc ggggcgccag gcgctgtcgc
     3721 agcgcggacg tcatcaggcg gtccagggac agaccatcgc ggcggcccag ggccagcagc
     3781 gccgcacccg cgcccacggg gagggcggcg acggcgaaga cgggcagcgg caccagcgac
     3841 cgggtggcgg accagatgcc gtagagcacg atgccggtga ccgcgaggat cgtcagctgt
     3901 cgtgccgtca ggttcgccag gacggtgtcc tcgcggtcca cgtcggcggg gatccgtatc
     3961 gactgcgtca tggctggcta cctcctgggc cgcggccgat gcggcggggt cggccgcggc
     4021 ccaggaggta gccatgtctc ttttacacct ctccgagccc acaggacgga ctcctacccc
     4081 gtttaccgtt ttctgcttgc acagaaaact taccctaccg cccgcaccgg tcaacgcctc
     4141 ctcgccctgg ccacggccat ctggcacaac tggaccaccg gagcccgaag caaacgatct
     4201 ctcatcgcct acgaccacta agaacatcgg actcattcat ctaggaggta taccgggcga
     4261 aacccgcccg gtatacgagg gagacttccg gacatgcccc gccccatcgc ccgcgtcctc
     4321 gccctgctgg agctcttgca gtcgggcggc atccgtacgg cggccgaact cgccgaccgg
     4381 ctcggcgtgg acgaacgtac ggtgcggcac tacatcggcc acctcatcga cctcgacata
     4441 cccgtcgagt cggtacgcgg ccgccacggc ggctaccggc tcgcccccgg ccaccgcatg
     4501 ccgccgctca tgctgaacga cgacgaggca ctcgccgtgg cgctcggcct ggtcgcgggc
     4561 gagcgggccg gactgacgcc ctccacgagc acgggcacgg gcacgggcgc gggcacgagc
     4621 acgggcgcgg gcgcgagcac gaacacgggc acgggcaccg cgagcgagac ggcggcggcc
     4681 aagatccggc gggtcctgcc cggacggctg cgcctcaggc tcgacgccgt gctcggcagc
     4741 ctcgccttca cggccccgcc ccgcactccg gccgcggccc cggcgaccga agtgctcctt
     4801 ccgatcgccg acgcggtgaa ccaccaccgg ccggtcacga tccgctacac ctccgcggac
     4861 ggccgccaca gcgagcggac actgcatccg cacggcctcg tcgttcactc cgggaagtgg
     4921 tacacgacgg ctgcggatct cacgtccggc caggaccgta cgttccggct ggaccgcatc
     4981 accgacgtac ggaccctgcc gggctccttc gaaccgccgc ccgccgccga tccggcggag
     5041 cgcgtgctga cggcgctcgc cacggctccg taccggtacg aggtgtcctt gcgcgtccag
     5101 gccacggccg agcacatcca cacgcggctt ccgcccagcg tcgccgtcgt ccacgaactg
     5161 ccgtccccgg gaggcgcgga cgcgcagacc gagcgctggt cacgcgtcgg actgcgcgtg
     5221 gaccggctcg actggctgcc cgccgtcctc gcctcgctcg accggccgtt cgtcatcgac
     5281 cggccggacg aactgcgcgg cctcgtcgag gccctggccg aacggctcac ggcctcggcc
     5341 cgccggactc cgccccagga ctgacgtgtt gccgcaaacg atgcggcgtg cggaacccgg
     5401 cgccgcgcgc gagccgcact gacacagatc gtcaactgat cggctctcac gggactggtc
     5461 gccgtaccgg ccctgcgtaa gggttcaagg aggcggctgt gcggcattcg cgcactccgt
     5521 cccctgccct gccgcgccga gtgttcaggc gtatccgcga gagaaggaat cccacccatg
     5581 cgcgcccttg tggtcgatca cggcgaggcc ggacccgtac ggttcgccga tgccgatgag
     5641 cccgagccgt ccagcgacga ggcgctggtc gagatacggc acatcggtct caacttcgga
     5701 gagctgaatt acgtgcacca gtggccggcc ggcaccgtgc acggtcacga cgcggccggc
     5761 gtcgtggtgc gcgccgcgtc cgacggctcg gggccacccg agggtacgcg cgtcgcggtg
     5821 gggatgtcgc cccacgcgtg ggcggagcgg gtggccgtca gacccgcctc gctcggcacc
     5881 gttcccgagg gcgtggacct ggccgacggt gccgcgctcg ggatcgccgg agtcaccgcg
     5941 ctgcgggtgc tgcgcaagcg ttccctgctg gcgcgcgacg tcctggtcac gggcgccagc
     6001 gggggcgtgg ggcacttcgc cgttcagctg gcggcgctgg cgggcgcccg ggtgacggca
     6061 ctcgtgggtt cgccggaccg ggccgccgga ctccgcgaac tcggggccga ccgggtcctg
     6121 accgacccgg cggacttgac cggcctgacc ggcccggccg agaccgagcg ccggttcgac
     6181 ctcgtcctgg acacggtcgg cggaccgctg ctggcccagg cgtgggattc cctcgccgag
     6241 ggcggcacca tccacctggt cggatactcg tcggggcagg acaccacgtt cccgtcgggg
     6301 gctctctttg gcttcggcga accccgcagc atcgccacct acggcgacat gacgccgacc
     6361 ggcggggagt tgacggacct gctggacctc atggccgccg ggaggctctc ggcacccgtc
     6421 ggactgcgcg gccactggcg ggacgtggac gatgccgtcc aggcgctgtt cgcgcggaag
     6481 gtgcacggaa agatagttct cgacgtggtc tgatcttccg tcggcgagaa tggaacggtg
     6541 gacgtactcg cggaggcctt gcgtgtatcg ggtgcgcgag gagcgctcgg ggtcgtgctg
     6601 aaggccggag gagcctgggg cctctggctg gactcctatc cgggaggggc actgcacgtg
     6661 gtgtcccggg gcacggtgtg gctccacgtc ccgggcggga aaccggtgga ggtgcgggca
     6721 ggagaggccg tcatggtgtc gccgggcacc gcccacggga tagcgagcgg ggccagtacg
     6781 acgatgggtt cctgcgaccg ggaggcgacg gaccgggccc tcaccgaggg cagcgccctg
     6841 cacctgggct cggcgccggc gcagacggaa gtgctcgtcc tgcactacga gcaggacccg
     6901 gaggtgagta cgccggtgct cacctccctg gcccggccca tgcacatcac gagccgggag
     6961 aacgcgcagc tcggcaagac cgtcgagctc ctcacggcgg agctcgcgca cccgcagacc
     7021 ggcaccaccg ccgccgccgt caacagcatc gtcgacctgc tgctcatcca gttcgtacgc
     7081 gtctggctgg cccgccaccc ggagatgcgg tcaggctcgt ggctgggcgc gacgcgtgac
     7141 ccggtcgtgc gcgacgccct ggcatgtgtc cacgcccgac ccgaacaccc ctggaccacc
     7201 gagtccctgg cagccgcgac ggcggtctcc cgtacgacgc tgtccaggca cttccggtcc
     7261 gctctcggac agacgccggg cgcgtacgtg acgcagtggc gcatggacct ggcgtccgtc
     7321 cggctccgcg acaccgacga gccggtcgag tcgatctccg gcgcggtcgg ctacgcctct
     7381 ccgcacgcgt tcagccgcgc cttccggcgt gcccggggca tgccgccggg cgagtaccgt
     7441 tcccggcttc gcgggtgatc gcggcgcccc gcgtcggtca ggtggagtcc cagtcctcgg
     7501 gtgtgatgac aaatcccctc tgcgggccgc cgcccctctg cgcgctccgc gtcggccctg
     7561 cctccccctg aaggggagcg ggcggctggc cactgaagtg cccgacgacg gcggccagta
     7621 cgtccgcggt gacgtcccgc cgtacggccg ggtccgcgcg tcgtacaccc gccatgcccc
     7681 gccgggatcg ccggcgtcag ccggtgccac gacccctccg atcgcgaggg cgcgcagcac
     7741 cgcgtcaacg cgcctggcct catctggtcc catcggatgc ccgccttccg ctcggctctg
     7801 gacagagact gtgcgcccgg gccccggatt ggggccgatc ggcccgcagc cgcccggtac
     7861 cgggtacacg gtgttaaagc ccgtcggccg ggtgtgcggc gtcgacgatc gcctggagtg
     7921 ccgcgatgtg gccgtcgaag gcctcgcggc cggcgggggt cagccgggcc cgtacctttc
     7981 ggcggctgcc gctgatccgg cgttccgtgg cgacgtaacc ggcctcttcg agggtcgcga
     8041 gctgcttgga cagcgccgag tccgagagcc ccagccggtc cctgaggaag gcgaactcgg
     8101 cccagtccgc ggcggccagc gtcgccacca gcgacaggcg ggtgctgggg tggatcaact
     8161 cgtcgaactt cgccgcggtc atgcccgcgc ccaaccacgc agcacgcgca ggatgtccgg
     8221 tccgccgaac ccgatgacga ccgccatcag gccccccgcc cagatgctcg cgtggccggc
     8281 gccgtcggcg tccagcgcga gcgccgccag gacggtgacc gcgacgagac cgagcagcat
     8341 gccgaccacg acgacgggga tgcggcggcc ggcgacggag gcgctcacct ggatctgccg
     8401 cgtgcgccgc cgtccggtga gcagtcgcga ggcgaacacc gcgtggcccg cgccgaagag
     8461 gcccgccgcg atgcctgcca gccacggcag caccgcgccg catgcgccca gtaccagcca
     8521 gccggcggcc atggcccacc agtagccggg tggcaggccg atctcctcgg tgacctggcg
     8581 gcgggcgtgt tcggcagcgt cgagcgaggc gcgggcctgt tccgaagcga tggcgtccat
     8641 gatgagacct ctgtttcctg gtaggaaagt gagcgtttca ctttcctgct gggaaagtca
     8701 aggtcggtgc tcgccgcgac ctggggcccg gcgggcgtcg gcgccgcctg tgccgtcggt
     8761 caagtcccct tgatcgtctg cgagatcgcg ttctccggac gctccactac actgcccgaa
     8821 aatcgcgtgg ccccgggttg acctcctggg gtcggggacc gtccaaggga catcaacggg
     8881 gaggtacggc atgcatgccg tcggggatac ggaaccggaa tcgccgcacc gaagacggcg
     8941 ggccctcgcc cgcgctgccg ccgcgcgaac gtgcccggac cggcgcgtcg agggggtgcg
     9001 gggtggcggt gcgtgtcttt gtggttgacg agcaggcgct gttccgcgcc ggcatccgcc
     9061 acctcttgtc cgacgcggag ggctttgaac tggcgggtga ggcggagtcg gccgaaaggg
     9121 ccctccacct gctgcaggag ctgtctccgg cgcccgacgt cgtactgatc gacccccggt
     9181 cggaggcagg cgcgggcacc gtcgccatcc gggctctgcg gtccgaaccg gccccgccgg
     9241 acggcgcggt gaacggggcg gacgggggga acggggccaa cggagcgaac ggggtccgcg
     9301 gcggcagggc cccgcgtgcg ctggccgtct ccgtccagga cgacgacgac tcggtgatgg
     9361 cggccctgcg ggccggggcc agcggctaca tcaccaagca gacctccgaa cgtgagctgc
     9421 tgcgcgccat cgagatcgtt gccgagggcg gtgccgtgtt cagccccgtg atcgcgaagc
     9481 ggctgaacga atacttctcg acgccccaca cggcgtcgtg ccggtcgatg ttcccgcagt
     9541 tgacggggcg tgagacgcag gtactggacc tgctcgcgcg cggctggagc aacggccgta
     9601 tcgccaagga cctggtgctg acggagaaga cggtgcgcaa ctacgtctcg cagatcctcg
     9661 tcaagctgga cgtgcaccac agggcggagg cggtggtacg ggcacgcgaa gccggactgg
     9721 gggtcctttc ctgaccacgg gcgtggccgg tgcatgccga accgttttgg cgtgccaggc
     9781 caccgccgtg tggccaccgc cgtgccaggc caccgccgtg tggccgggca cgggcgacgc
     9841 cggggcgaac accccgaaaa cggggcggta accggaaccg ggacctccat gcggggacat
     9901 tttcgagaca gctgccccgg gagtccggga cacgggactc cctagcgtga gagccgcgcc
     9961 gatcacccgg cgcgtacgtc ccctccgcct ggagtcaccc gtgaccagcg agacccagca
    10021 gcccggccat ctctacgtcg acgacttcct cgctgtcagg gacgagacgg tcgcgctcca
    10081 cgggtggcac cactccgcgg acgacatgtg gtgccacgtg ctgccccccg ggcactgctc
    10141 acggccgcag ggctggaaga tccacctttc ggcgacgcca cgctccgcgg tgcccgtact
    10201 gcagggcgcc gcccgtgtgc tgctcgaacg cggcgtcgcc ttcaagttcg ccaagggcgc
    10261 cgcccagctg cggcagctgc tgtcggtgcg ctgccatcgc ggcagcagcg gcaagttcct
    10321 caccgtctac ccggagagcg accggcagtt cgccgagctc gtcgaggaac tccaccaggc
    10381 caccgacggc atgcccggcc cgaagatcct ctccgaccgc cggtaccggc ccggcagcct
    10441 ggtgcactac cgctacggcg gcttcaccag ccgccagcag gtcctcggca ccgacggctc
    10501 gtacgtaccg atgctggtcg caccggacgg cagctggtac caggacgagc gcgaggcgtg
    10561 gtacgcgccg gtgccctggt ccgcgccgcc ccttcccgac gaggcccccg ccccggctcg
    10621 gggcgacggg gaacgcggca aacagcgggt gctgctcgac tcccggttcg ccgtcttcga
    10681 agcgatcagg cactccaacc gcggcggtgt ctaccgtgcc aaggacgaac gcaccgcccg
    10741 tacggtcgtc atcaaggagg cccgcccgta cgtcgcggcc gagtccgacg gcaccgacgc
    10801 ccgcgactac ctgcgcaacg agcacgagat cctgcgcctc ttcgagggga tgggcatcgc
    10861 gccccgcccg gtgtcgctct tcgagtacca ggaccacgtc ttcctcgcgg aggaggagat
    10921 acccggcgtg acgctgcggg cgtgggtgga ccgccacgta cgcgacgacc ccggccgcct
    10981 cgtctccctg gacgcggtgc tgccggtggc acgccggctg gtcgacctgg tcgccaccgt
    11041 ccacggcaag ggcctcgtct tccgcgatct gacgccgaac aacgtcatgg tcacccccga
    11101 cggcgaactg gtgctgatcg acaccgagtt cgtgacccgc cccggcgagc aggtgacgcg
    11161 ggtgatgacg atggggtacg tggcgccgga ggagatgtcg ggcccggcgc gccacccggc
    11221 gcccggccag gagaccgacc tgtacagcct gggtgcgtcg ctcttccacc tcagcaccgg
    11281 catccacccg ctgctggccg aggactcctc ccccgagccg cgcccgctcg acggccgcgt
    11341 ggcgtccctg gtggaggccg tcgcgggcac cagccccacc ctgcgcgcgt tggcgccgct
    11401 ggtgctgggc ctgctgcggc aggacccgcg gcagcgcatc gggctgacgc gggtgcggga
    11461 actgctcgcc tcgacggcgg cacgggagca cgacgacggc tcggcggcac ccgtacggct
    11521 gccggcgggc gagcagcagc ggctgctgga cgactccgta cgggaactcg tggcggcgat
    11581 gacgcccgac gacgaacgga ccctgtggcc ggcctttccg tacggcggcc ggcagtccga
    11641 cccgctgagc ctgcaggcgg gttgcgccgg ctcgatcgac gcgctgcggc gcacgctggc
    11701 cctcggcgcc accggcgaat gcgccgggac tgacgggcct gggagcaacg ggaccgacgg
    11761 ggccgccggg gccgccgggg ccgacgccgt acggggtgcc ctgcggacct cggtgacatg
    11821 gctggaggcc cggctgcgcc aggaccaacg gctcctgccc ggcctcttct tcggccgcgc
    11881 cggcacctgc tgggcgctgt acgaggcggc cgaggcgctg ggggacgagg acgccatgcg
    11941 gcgcgcggtc gagcgggcga agcggctgcc ggtcgcgtgg gccaacccgg atgtcaccca
    12001 cggcgtggcc ggttcgggcc ttgcccagct ccacctgtgg cgtcgtaccg gcgacgacga
    12061 gctggcccgc cgggtggcga tctgcgccga gtccgcgcag gccgcccgcc cgtcgggtgg
    12121 gtcgacgcag tggcggctgg ccgattcgcc cggtggccgc tcggcgggcg gtccgacaca
    12181 cctggggtac gcacacgggg tcgcgggcat ctgcacgttc ctgatggccg ccgctcgtga
    12241 gctggaccgg cccgagctgc tgacgacggc cgccgaggga ggcgactacc tgctgtgcgt
    12301 cgcccgggag cagggggacg gcgctacctg gccggtctcg ccgccgcagc cgggcgacga
    12361 ggagccacag gagggggtgt gctggtggtg cagtggcgcc tccggcatcg gcaccttcct
    12421 gatccggctg tggcgcgcca ccggagaggc caggtaccgc gaggccgcac accgtgcggc
    12481 ggtggccacc cgtgccgaga agtggttcct gtccgcgaac cactgtcacg gcatcgccgg
    12541 caacgccgag ttcctgctcg acatggcggc cgccacgggt gaacgggtgt accgcgactg
    12601 ggccgaggag tacgccacct gcctggctcg gctgtgcgtg ctgcgcgacg gccgcctcgt
    12661 tcccgtcgac gaagcgtccc tgaggaccac ctacagctac ggcctcgggc tggccggttc
    12721 gctgggattc ctgcaccggc tgcgccacgg cggcgaacgc tggtggatgg tggacgactt
    12781 cgccctggcg ccggagggcc tccggtgagc ggcgggccac gccccgccgg gcgggcccca
    12841 gaaccctctc ccgaccacgg tgcgagctcc ggccgcgcgc gggtggagcc cgtacccacg
    12901 tcgagtacgg ggagggggtg cgagagaccg cacagcaaca gcaacagcaa cagcaacacg
    12961 tacgtcaaca cgggctgacg gcacggccgt cagtccactc gccaccagga aaggaccagg
    13021 ccatggccaa cgacgtcgaa cttctccagg agcttccgga gaccgaggac accgcgaccg
    13081 tgatggacga cggctgctgc gcatgggcca gcgtcatcac ctgcttcagg accacgtact
    13141 gacatcgagg ccccggcggc tccgcggagc cgccggggcc ggcaggccgg tgcgacggtc
    13201 agtgatccgg cagcggccgg ttcagtggcc ggttcagtgg ccggttcagc ggtcctcgat
    13261 gacgctgacc gcggtaccgt ccttgatctg gaccttggcg gagacgccct tcttcgcggc
    13321 ggcctcgagc tccgtctcgc tgcacttggt ggcggcctgg ccgttctcgt cgccgcagat
    13381 ctcgcccgcg ccctggatgt tggtggtcgt ggacgtgaag aaggcctgct ccttgccctt
    13441 catgtcgctg accgtgtact tgccgggggc gaggtaggag accgtcccga accaggtgcc
    13501 gctgacgccc ttgtccccgc cggagttgtc gccgccgccc gagcggtcgt cgatgatgct
    13561 gaccgcggtg ccgttcttga tctggacctt ggcggagacg cccttcttgg cggccgcttc
    13621 gagctgggcc tcggtgcact tggtggcggc ctggccgttc tcgtcgccgc agatgtcgcc
    13681 cgcgccctgg atgttggtgg tcgtggaggt gaagaactgc tgcttctggt ccttcatgtc
    13741 cgtcacggtg tacttgccgg gggcgaggta ggagaccgtc ccgaaccagg tgccgctgac
    13801 gcccttgccg cccttcttgc ccggcttttc ggccgagttc gcctgggtgc catcgttgtc
    13861 actcgcgctg tcgccgcccc cggtctcctg ctccgacgac gaggagccct tcgacttctt
    13921 gctgtccgag tcgctgctgc tgtcctggca ggcggtcatc atggcggtgg tcgcgacgag
    13981 ggcgacggtg gtgaggacgg tcttgcgagc gtgagtgcga agcatggtgt ggttcccccc
    14041 agatgaggtg ctcggtgcca gccgcccaac tccccggccg ctgcgctttc ttggtctgag
    14101 caccactctg gtcaacatca ccgcgccggg ggaagggcgg ttacggagtg atgacacagt
    14161 cgcggtcggt acgggacacc cgggacgggg cctgatcaaa agtcacgccg gggacgcgtg
    14221 tgatgcggcg aggcgcggaa aaccgctacc ggcgtgccgc gcgtacgtgc ttacgtgacc
    14281 gcatggtgcc caccgaccgt ctcctcgcct tcgccgtggc gtcgttcctg ctcatcgtcg
    14341 tccccggacc gagcgtgctg ttcgtggtcg ggcgggcgct cgcgcagggg cgccgtgccg
    14401 cgctcacgac cgtcgtgggg aacacggtcg gcgcgtacgt cctcgtggcg gccgtcgccc
    14461 tcggcgtggg ctccgtggtg gagcgctcgg cgctcgtctt caccgcgctg aagctggcgg
    14521 gcggcgcgta cctggtgttc ctgggggtca gggccgtacg ccagcggggt tcgctgcagg
    14581 cggcgttcgc gggggagggt ccggcggcgc aggggggact gcgtacgttc tgggaggggt
    14641 tcgcggtcgg cgtcgccaac ccgaagacga tcgtgttctt cgccgccgtg ctgccgcagt
    14701 tcgtggaccg cggcgccggg cacgtggcgg cgcagatgct ggtgctcggc ctggtcttca
    14761 acgcgatcgc gctggcctcc gacagcgtgt gggggctggc ggcggccacc gcgcgcaact
    14821 ggttcgcgcg ctcaccgcgc cgcctcgcgg tgatcggggg cgccggcggg ctgacgatga
    14881 tcgggctggg cgtgagcgtg gcggcgaccg ggcgcaacga ctgaggccgc ggggacggac
    14941 ggcgcgggac cgaaggccgg ggtcggggcc ggtcagcccc aacgggcggc gccggcgcgc
    15001 tgatcctccg ggcgcgccgc ccgccggagg gcgttaccca ggccgcgaag cccgcgacag
    15061 catgagctca atggccgtgc cgaccgtgta ctcgtactcc gcgtacctgt cgaacctcgc
    15121 cagatgggga gcggcctcgg ccgtcctcgg aagtccggac cgctccaggg tctgccggcg
    15181 cgccgcgacg gcgctgtcgc cgacgccgaa ggcctggccg gcgtggacct cccggaggag
    15241 cgtgccgacg agggtggcga cgaacacgcg cagcaggtgt acggactcct cgagcgggca
    15301 gccggcgtcg cgcagcacgg agagcagcgc ttcggtgggc gcaagccctt cgagcgaggc
    15361 cagttggcgc gtgagggtga gcgccgcggc ctcggggtgg cggagtgccc tgtcccggaa
    15421 ggcgtcggcg atggcgcgca ggtcgagtcg tacgtcaccg gtgcgggccg ggatctccat
    15481 cccgctcagg agatgttcgg cgacggcgtc caggagcccg tccttgccgt gcacgtggtt
    15541 gtagaggctc ttggcgtcca cgcccaggag cctcgcgacg gatcgcatgc cgacggcgcc
    15601 gacgccttcg gcgtcgatga cgcggagggt cgcgtcgacg atcgactccc gggagagccg
    15661 ggtggcgccc ttcggcgggc ggcctcgacg ggcggcgttg gccggggctt gcgcgcgggt
    15721 catggcgaca ttgtgcaggc ggcagcgtgc agacggcatg gtgcagacgg cggggacgtc
    15781 ccgtccctgg cattaaccca cggcgtgggt aaaatactgg ggccgatgcg ctgccgcccc
    15841 cggtccgagc cgctgatccg agtcgctgag gagcctcgcc atgtcccttc ccccgcgctt
    15901 caccctgccg cccgaagacg tcctgcgcgc ccgggagaag ctggttctgg accacttccg
    15961 cgacgaggtg cgccaggact gggacgccac gctctcgacg ttcccgcacc cgcgctacga
    16021 gctgatcgcc ccgatgcagg tccacgacgg cgacggcgag gtccgggcgt actaccacga
    16081 cacccgcgtc gcgttccccg accagcacca cgagctgatc gcgctccggc acagcgcgga
    16141 cgcggtgatc gtggagttct ggctgctggg cacccacaac ggtccactcg gcgcgatccc
    16201 gccgaccggc agcacgcacc gcacccggat gacggcgtac ttcgtcttcg acgagcacga
    16261 gaacctcgtc accgagcgga tctacttcga ccagctcacc atcctcggac agctcgtcgg
    16321 cggcctcgac aagcgcaagc ccacgggcct gctcaagctc gcccgagtgc tcaagggcgc
    16381 catgtcgaag tccggcggca agcccgaccc gcggctgctc ggcaccaccc cgcccgacct
    16441 caccggctga ccggacggcg ttcacgggcg cgggaaaacc ccgtgccgta cgggacaccc
    16501 gtacgcaaca ctcaccgcat gaccgccgcg ctcgcgccac ccctaccgcc cgcacccgtt
    16561 caggccctga tcgtcgtgga cgtgcagacg gcgttcgtca ccggcacggc cgccgtgccc
    16621 ggcgcggccc ggctgctgcc gcgggtcgag gacctggtgg cgcgggcgcg tacggcaggc
    16681 tcgctggtcg tccacctcca gaacgacggc ccgccgggcg cggacgacga accggacacg
    16741 cccggctggg agttgtacct gccggtggcc gaaagcccgc gcgagacggc gctgcgcaag
    16801 acggaggacg acggcttcgc gggcacgccg ctcggcggac tcctcgacgc ggcaggcgta
    16861 cgggacctgg ccgtgtgcgg tgtgatgtcc gagatgtgcg tcagcgcgac ggcccgtacg
    16921 gcgctggcgc gcggccaccg cgtcgtcgta ccgcacgacg cgcacgccac gcagaacatc
    16981 ccggcggcgc ccggcatcag tgggcccgtc ccggccgcca tggtgtcgcg ggtggccgag
    17041 tgggcgctcg gcgacggggc cgagatcgcc gcacacgccg ccgacgtcgc cttcgccccg
    17101 cccggctgaa cagccccgcc cgccgactac cccttcgcga tgaacccgtt ctcgcggagg
    17161 aagcgcagcg ccgcctcgtc cggtgtcctg ccgtccaggt cgaccatcgc gttgaggtcg
    17221 atgaccgtct ccttggtgag ctcgcggccc aggcgctccg ccagctcccg cagctcaggg
    17281 tgcttccgca gggtgtcctc gcggagagtg agggccgcga gctccgtcgt gaagtggccc
    17341 ttgtcgtccg tcagtacctt caggtccagg gactccaggc gggcgtccgt cgtgaacacc
    17401 tcggcgagcc ggcaggggct gcccttcgcc acgttgacgt agttgagggc gagcgcgttc
    17461 tggtagacct gcggcgacgg gaacgagacg ccgtacgtct tctggagcgc ccggatctcg
    17521 cggtccagga actccgaggc accgcacagc gtcagctcgt ccgggtgctc ctcgccgagc
    17581 cgcttcaggt cgctgagctt ctccacctcg cccacgggcc cgtccgcgtc gcccgcacgc
    17641 gcgatggcgt actggttgcc gaaccgggcg ggcccgagcc actcgatgcc gtgcttctcg
    17701 gcgtcctcgc gtgccgtcgc ctcgtactgc cgcttcgacc cctgcaccgg ccggtcgtgg
    17761 ccgaggaact gggtccagcc ggtgccgctg tactcccagt acatgtccac gtcgccgctc
    17821 ttgagcgcgc cgcgcacgat ggcggagccg ttcaggccgg tctggtcggc cgtacgggcg
    17881 cccgccgcgc ggagtgcgta gatcatgatc ttgccgagga tcttctgctc cgtgaactcc
    17941 ttcgagccca ccgtgaactc cgcgccgtcc aggtcgaagt ccttcgccag cgacccgccg
    18001 cgcagctcgc gcgcgccgac cgaaccggtg tcgcccgccg cgccggagca gccgctcagc
    18061 gcgggcacgg ccagtgcggc ggccagggcg agcagcaccg cgagccgccg tggggttgtc
    18121 cttggggtgc gcacggcgtg caccaccttc ctttccgtgt ccggatgcgt cacaggccgc
    18181 gcggccgcag gaagtcctcg gccatgcccg ccagccagtc gatgaacagg gcgagtacgg
    18241 cgacgagcac gctgccggtg acgaggacga ggttgcggct ggagctgatc ccgttcgaga
    18301 tgacgtcgcc gagcccgccc gccccgatga acgtggcgag cgcgaccgtt cccacggtga
    18361 tcaccagcgc cgtacggacg cccgcgagca tcaccggtac ggccagcggc agttcgatcc
    18421 gccacagcac cgccccgcgc gtcatcccca tgccctcggc cgcctcgatc accgagcggt
    18481 ccacctgctg gagccctgcg atggtgttgc ggaggacagg caggatgccg tacgcgacga
    18541 acgcgatgac cgcgatctgg ttcacgccga ggctgacgaa ggcgaccgcc agcagcacga
    18601 tgagccccag cgacggcagc gcctgcccga tgctcgcgac ggcgagcacc ggcccggcga
    18661 tacggcgcgc ccagcgccgc gtcagcagca caccgagcgg aatggcgatc accaggatca
    18721 ggacggtgac gacggcggtg agctccaggt gcttgaccgt acggctcacc aggtactcgg
    18781 agttgaggct gcgctcctcg atcaggtccc gctgctgcga ggagacgtgc agggcgagca
    18841 cgagcagtac gacaccgagc ccgagcgggg tgagggcgta gcgcagcagc gcggcgcgcc
    18901 tcgggcgcgc gggcgcgcgt gtcggcgccg atacgggcgc gggtgtgggc gccggcgccg
    18961 gtgcggtgga cgtggatgcg ggcatcgcgg ctacgcctcc tgcaactggt cggagccgtc
    19021 cgtacggccg cgcccgtgca ccgtgttgat cagcgcgcgc agggagtcca tctccaccac
    19081 gccccggtac cggccgtcgc cgtccaccac cgccagcacc gacgagttgg ccgccagcat
    19141 gtggtccagc gcgtcgaaga ggctgtcgcc cggaccgagc gcccgcagca gcggcagcgc
    19201 cccgccgacc tcccgcccgg cgccggtgac cggcagccag ctcgtcggcc ggtcgtcgtc
    19261 gtccaggacg agcaggtgat cgcgctccgt acgggcggct gccgtacggc gctgctcgcc
    19321 gtccgcggac tccgcgacgg tcggccacgc cggcagctcc aggctgtcca tccgggtcag
    19381 cgacagcctc cgtacggagg cgcccgcacc gatgaagtcg gagacgaaac cgtcggcggg
    19441 gtcggccagg atgcgttcgg gggtgtcgta ctgcagcacc ttgccgttgt cggcgaagat
    19501 cgcgatcaga tcgcccatac ggacggcctc gtcgatgtcg tgcgtgacga agacgatcgt
    19561 cttccgcacc tccgcctgga tgcgcaggaa ctcgttctgc agcgactccc tgttcaacgg
    19621 gtcgatcgca ccgaacggct cgtccatcag catcacctgc ggatcgccgc ccagcgcccg
    19681 cgcgacgccc acccgctgct gctggccgcc ggagagctgc ttggggtagc ggcggcggta
    19741 cgtgtccggg tcgaggccga cgagccgcag cagctcgtcg acgcgtgcgg tgacgcgctg
    19801 cttgtcccag ccgagcagcc gcgggacggt ggcgatgttg tccgccaccg tacggtgcgg
    19861 gaacaggccg ccctgctgga tcgtgtagcc gatacggcgg cgcagcaggt gcgcgggcac
    19921 ctcggtgacg tccttgccgt ccaggtggat gcggcccgaa gtgggctcga tcagccggtt
    19981 gatgagtttc atcgtggtcg tcttgccgca accggacggg ccgacgaacg tcacgatccg
    20041 cccctcgggg atgtcgagcg tcagctcgtc caccgccgcc tcggactggc cggggtagcg
    20101 cttcgtcagc cggtcgaggc ggatcatggg gtccacgtgg gcgttcgcgt tcgcgtcagg
    20161 agtcttttcg gtcatgatca ggcaccgagt cccttgggtg tggtgagtcg gttcacgacg
    20221 gcgtaagcca gatcgaacag cacggccagc agcacgatgc ccgccgcgcc ctcgatggtc
    20281 agatagatcg cgaacggcgt gcccgcggtg gccaggccgt ccagaatgag attgccgagc
    20341 ccgggcccgt tcaccgccgc cgcgatggcg gcgatgccca gcagcagctg ggtggccacg
    20401 cgcaacccgg tgagcagcac cggccaggcc aggggcagtt cgaccgtcgc cagcacccgc
    20461 gcccggccca tgcccatcgc gcgggccgac tcgacgacgg ccggatccag ctcccgcagt
    20521 cccacgatcg tgttccgtac gacgggcagc agcgcgtaca gcgtgagcgc gaccacggac
    20581 gggccgctgc ccagcccgag cggcgtgatg agcagcccga acagcgcgta cgacgggatc
    20641 gtcagcagca gcccggccac ggccagcacg gcggcgcggg gcgcgcctgt acggtacgtc
    20701 agcaccgaca ccggcacccc gatcagcacg gccagcccga gcccctggag caccaggagc
    20761 gcgtgcgcga ccgtggcgtc caggacgtcc gtccagttcc cctggaggaa ttcgaagaag
    20821 ttcatggcgg ccggtccggc ggctaggcgt tggccgtcgc gggcgcgggc gcgggcgcgg
    20881 gcgcggatgc gggtgcgctt gcgtgcggcg ccgcggcggg cgcgggtacg ggctgggcag
    20941 ccgggccgtg cgcgaacgcc tccgcgtaga acgcgtccag ctcctccacc agcgcgcgga
    21001 acgtggggtg ttcgtcgaac atccactccg tgtgcccggc cccctcgatg aggtgcagcc
    21061 gcttcggctc ccgcgcgtgc tcgtacagcg cccgcgcctc ctcagggagg tgcagcccgt
    21121 tctcggcacc gtgcacgacg agcagcgggc gcggtgcgat ccggtgcacg acgctctgtg
    21181 gcgagaaacg gagaagcatc tccgcggact ccagcgagac gcccgaaccg aagcccggcg
    21241 ccttgtacag ctcctcgccc acgtagccgt ccgtccggcc gtcgcggtcc agccgcacga
    21301 tgtcccacgg cgacgtgatc tccgaacggc cccgctccgc ccgccgcccg cggtctcccg
    21361 cgatccgctc cagcaggctg ttccaggtgg cctcgtcgtg catgttccgg gtcgaacggg
    21421 tgccgtcact gatgcagttg acggacgcca ccgcccgtac gcgcagatca tccgccgcct
    21481 ccgcgacgac cacgccgccg cccatgcccc agccgagcag cgcgatacgg cccgcgtcga
    21541 gcagctccgc cgcggcggcc cggtccacgg cggcccgcag atcctccgcc cactcctgcg
    21601 gcaccagccg gccgcgctcg ccctcgctcg taccgaaacc gcggtagtcg aaggcgacga
    21661 cggcatagcc gcgggccgtc agcgcgcggg cgaaacgctc ggggtggatc accttgaggc
    21721 cctggtagcc ggaggcggga atcaccaccg gatacggcgc gcccgccccg ttgtcgtccg
    21781 ggaggtgcag gtcggcgtcg aggcgcagcc cgctgctgaa gaagggaaag gcatgggtgt
    21841 gcacggtgtg gttcctccgg gggtgcgtcg tgtgcggtat gggttacgcg ttgggttgta
    21901 cgggtgtgtg gtgcggtgcg gtgccttgcg gtgcggtgcg ttgcgttgcg ttgcgttgcg
    21961 ttgcgttgcg gtttcgcgtg ttgcggggtt acgtgcggtg ctacgcggtg gcctgctgct
    22021 ggcccgccat agcgcgggag acctgccggg ccgccgaaca gaccacgcgg cccgcccggt
    22081 ccagctcgga gcccatccgg tacgtgggcc ccgacacgtt gagcgcggcg acgacacgcc
    22141 cgcggaagtc ccgtacggga gccgccgcgg cgaccagccc cgcctcgaac tcctcctgca
    22201 ccaggacgta cccccgctcc cgcgcccgct ggaggcgggc caggaagtcc tccgcgtcgc
    22261 gcggcgcggc gggctcaccg gcgccgaaag gggtgtccgc gaggagggcc ctcacctcgt
    22321 cgtcgctgtg gtcgaacagc agcgccctgc cggaggacgt ggtgtgcagc ggggtcaccc
    22381 tgcccaccca gcccgtcgcc tgaacggcgc gcatcgggct ctccgacagc acggtcagcg
    22441 cgccgtcctc ggtgagcacg gtgagatgca cccgctcctt gagcacgttg acgaggctcc
    22501 gcagtacggg gggtgcctcg gcgagcagcc gcggccgtcc ggcgttcact gccatcgtga
    22561 acacgcgcca gcccagccgg tacacgagcg agtcgcggtc ccgctcgacg aggccgacct
    22621 gatcgagcgc cttcagcgcg cgggagacct gggtcttctc ccggcccacg cgccgcgcga
    22681 tctcgaccac cccgagccca ccgcgctcgg ccgcctcgtc ggaccctagg gccgtcagga
    22741 tggcgagcgt gcggtgaagg ctcgacgaac tgtccgttgc catgcgggga gcatgccgtg
    22801 ggtttgtg
//
