LOCUS       NZ_CP031320            22450 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces armeniacus strain ATCC 15676 chromosome.
ACCESSION   NZ_CP031320
VERSION     NZ_CP031320.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces armeniacus
  ORGANISM  Streptomyces armeniacus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8083249)
  AUTHORS   Labana,P., Gosse,J.T. and Boddy,C.N.
  TITLE     Draft genome of the type strain Streptomyces armeniacus ATCC 15676
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8083249)
  AUTHORS   Labana,P., Gosse,J.T. and Boddy,C.N.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-JUL-2018) Department Of Chemistry and Biomolecular
            Sciences, University Of Ottawa, D'Iorio Hall, 10 Marie Curie,
            Ottawa, Ontario K1N 6N5, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUL-2018
            Assembly Method                   :: SPAdes v. JULY-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 65.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003355155.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:13:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,031
            CDSs (total)                      :: 6,963
            Genes (coding)                    :: 6,742
            CDSs (with protein)               :: 6,742
            Genes (RNA)                       :: 68
            rRNAs                             :: 6, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 221
            CDSs (without protein)            :: 221
            Pseudo Genes (ambiguous residues) :: 0 of 221
            Pseudo Genes (frameshifted)       :: 36 of 221
            Pseudo Genes (incomplete)         :: 204 of 221
            Pseudo Genes (internal stop)      :: 5 of 221
            Pseudo Genes (multiple problems)  :: 22 of 221
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:36:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4289527
            Orig. end                         :: 4311977
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031320.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22450
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="19"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22450
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22450
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12450](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12450
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            1575..3443
                     /locus_tag="DVA86_RS18480"
                     /old_locus_tag="DVA86_18635"
     CDS             1575..3443
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003984 - acetolactate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469941.1"
                     /locus_tag="DVA86_RS18480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18635"
                     /product="acetolactate synthase large subunit"
                     /protein_id="WP_208879752.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.4e-53, bitscore:
                     178.1, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.3e-50, bitscore:
                     167.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQATGAPKPQPRARNGGHQQPATVEHMTGAQSLIRSLEEVGAD
                     TVFGIPGGAILPAYDPMMDSTTVRHVLVRHEQGAGHAATGYAQATGKVGVCMATSGPGA
                     TNLVTPIADAHMDSVPLVAITGQVASAAIGTDAFQEADICGISMPITKHNFLVTDAAEI
                     PRTIAEAFHIASTGRPGPVLVDIAKDALQTRTAFSWPPQQDLPGYRPVTKPHAKQIREA
                     AKLIAAAERPVLYVGGGVLKARSTAELKVLAELTRAPVTTTLMGIGAFPDSHPQHLGMP
                     GMHGTVAAVTALQKADLIVALGARFDDRVTGKLDSFAPYAKIVHADVDPAEIGKNRAAD
                     VPIVGDAREVIADLVVAVQAEYEARRGEEGAPDGYQEWWNQLNRWRETYPLGYDLPDDG
                     SLSPQQVIERIGQLAPEGTVYAAGVGQHQMWAAHYIRYEQPATWLNSGGLGTMGYAVPA
                     ALGAKVGVPDRTVWAIDGDGCFQMTNQELVTAALNNIPIKVGIINNGALGMVRQWQTLF
                     YNQRYSNTVLHAGPEADGKTPSHGTRVPDFVKLAEAMGCVGIRCEDPEQLDAVIEKANS
                     INDRPVVVDFIVHEDAMVWPMVAAGTSNDEVMAARGVRPDFGDSDD"
     gene            3463..3987
                     /gene="ilvN"
                     /locus_tag="DVA86_RS18485"
                     /old_locus_tag="DVA86_18640"
     CDS             3463..3987
                     /EC_number="2.2.1.6"
                     /GO_function="GO:1990610 - acetolactate synthase regulator
                     activity [Evidence IEA]"
                     /GO_process="GO:0009082 - branched-chain amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ilvN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925060.1"
                     /locus_tag="DVA86_RS18485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18640"
                     /product="acetolactate synthase small subunit"
                     /protein_id="WP_208879754.1"
                     /transl_table=11
                     /translation="MSKHTLSVLVENTPGILARIAALFSRRGFNIDSLAVGVTEHPDIS
                     RITIVVNVEDLPLEQVTKQLNKLVNVLKIVELEPGGAVQRELVLVKVRADNATRSQIVE
                     IVQLFRAKTVDVSPEAVTIEATGGSDKLEAMLKMLEPYGIKELVQSGTIAIGRGARSIT
                     DRSLRALDRSA"
     gene            4062..5060
                     /gene="ilvC"
                     /locus_tag="DVA86_RS18490"
                     /old_locus_tag="DVA86_18645"
     CDS             4062..5060
                     /EC_number="1.1.1.86"
                     /codon_start=1
                     /gene="ilvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957827.1"
                     /locus_tag="DVA86_RS18490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18645"
                     /product="ketol-acid reductoisomerase"
                     /protein_id="WP_208879756.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 2.6e-06, bitscore:
                     25.5, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELFYDNDADLSIIQGRKVAVLGYGSQGHAHALSLRDSGVDVRV
                     GLHEGSKSRVKAEEQGLRVVTPAEAVTEADVIMVLVPDPIQAKVYEESIAPHLKDGDAL
                     FFGHGLNIRFGFIAPSAGVDVCMVAPKGPGHLVRRQYEEGRGVPCIAAVEQDATGKAFA
                     LALSYAKAIGGTRAGVIKTTFTEETETDLFGEQAVLCGGTTALVKAAFETLVEAGYQPE
                     IAYFECLHELKLIVDLMYEGGLEKMRWSVSETAEWGDYVTGPRIVNDQTKAEMRQVLAE
                     IQDGSFANNWMKEYNAGLPKYNEYKKADEDHLLETTGRKLRKLMSWVDEDK"
     gene            5344..6933
                     /gene="serA"
                     /locus_tag="DVA86_RS18495"
                     /old_locus_tag="DVA86_18650"
     CDS             5344..6933
                     /EC_number="1.1.1.95"
                     /GO_function="GO:0004617 - phosphoglycerate dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006564 - L-serine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="serA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544805.1"
                     /locus_tag="DVA86_RS18495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18650"
                     /product="phosphoglycerate dehydrogenase"
                     /protein_id="WP_208879758.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.4e-61, bitscore:
                     205.6, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKPVVLIAEELSPATVDALGPDFEIRQCNGADRAELLAAIADVD
                     AILVRSATKVDAEAVAAARKLKVVARAGVGLDNVDVPAATKAGVMVVNAPTSNIVTAAE
                     LACGLLVASARNIPQANSALKNGEWKRSKYTGVELSEKTLGVVGLGRIGVLVAQRMSAF
                     GMKVVAYDPFVQPARAAQMGVKLLSLDELLEVSDFITVHLPKTPETLGLIGDEALHKVK
                     PSVRIVNAARGGIVDEEALAAALKEGRVAGAGLDVYATEPCTDSPLFEFDQVVCTPHLG
                     ASTGEAQEKAGISVAKSVRLALAGELVPDAVNVQGGVIAEDVRPALPLAERLGRIFTAL
                     AGEVAVRLDVEVYGEITQYDVKVLELSALKGVFEDVVDDTVSYVNAPLFAQERGVEVRL
                     TTSSESPEHRNVVIVRGTLGTGEEVSVSGTLSGPRHQQKIVAVGEHDVDLALADHMAFL
                     RYADRPGVVGQVGRILGETGINIAGMQVSRATVGGEALVALTVDDTIPAAVLTEIAGEI
                     GATSARSVNLEG"
     gene            7158..7829
                     /locus_tag="DVA86_RS18500"
                     /old_locus_tag="DVA86_18655"
     CDS             7158..7829
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014055115.1"
                     /locus_tag="DVA86_RS18500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18655"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_208879759.1"
                     /transl_table=11
                     /translation="MRADAQHNREQILRAARQIFVHEGPDAPLDVIARRAGVGVATLYR
                     RFPTRDDLIRAVAADTLELLYEGVTRAAAEEGDPFEALRRFMHAALDLNIGAVMPSLFG
                     RFEADRVLSEVRDAVDPLHDLMSRAQEAALLRADAAPGDVIFMIIRLTRPLPGGGFPED
                     GALAHRQLEIYIDGLRPSAAWPREERLPGPAIGVPWFRRIRARMAKGMAGVEGGERDSP
                     S"
     gene            7986..9485
                     /locus_tag="DVA86_RS18505"
                     /old_locus_tag="DVA86_18660"
     CDS             7986..9485
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0009410 - response to xenobiotic stimulus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018842244.1"
                     /locus_tag="DVA86_RS18505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18660"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_208879761.1"
                     /transl_table=11
                     /translation="MATTTPAPIPSAAESNPRRWLALVFIGLAQLMIVLDITIVNIALP
                     SAQQDLGISSGDRQWVITAYTLSFGSLLLLGGRIADYTGRRRAFLIGLLGFAGASALGG
                     AAANFGMLLAARTLQGVFAALLAPAALSLLTVSFTEARERAKAFGVFGAIAAGGGAVGL
                     VVGGLLTEYLDWRWCLYVNVPIAVIAALGWTALPADQRSATRHRIDVPGVLLAVTGLVA
                     VVYGCSEAESEGWDSQLVVGLLSVGIVLLVSFVLYEGRRAERPLLPLRVIADRARGSAY
                     LAVALSVVAMFGMFLFLTYYMQVVKDYSAVLTGVAFLPLTAGVLLSAGGIASRLLPRVA
                     PRLLVVPGLLTTASGTLWLVFLEADTSYATGVLPAEILVGLGMGLVMAPAMNYATHGVR
                     PEDAGIASATVNTSQQIGGSIGTALLNTIATSTTSDYLADRPKAPPVLRDGLVEGFSAA
                     YAVATAILVAAAIAVGLLMNTPRPRRESGPAQDAPAAVHLG"
     misc_feature    complement(9583..9600)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     gene            9681..9821
                     /locus_tag="DVA86_RS18510"
     CDS             9681..9821
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DVA86_RS18510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_208879763.1"
                     /transl_table=11
                     /translation="MDKQLEDATLEAVESADIEFVGSLEDVTHGAALAPNFESIAGLCW
                     C"
     CDS_motif       9681..9767
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MDKQLEDATLEAVESADIEFVGSLEDVTH"
                     /locus_tag="DVA86_RS18510_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       9768..9821
                     /prepeptide="core"
                     /locus_tag="DVA86_RS18510_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class III"
                     /score="-5.20"
                     /molecular_weight="1707.0"
                     /monoisotopic_mass="1705.8"
                     /core_sequence="GAALAPNFESIAGLCWC"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MDKQLEDATLEAVESADIEFVGSLEDVTH"
                     /leader_location="[9680:9767](+)"
     gene            10001..10573
                     /locus_tag="DVA86_RS18515"
                     /old_locus_tag="DVA86_18665"
     CDS             10001..10573
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024862.4"
                     /locus_tag="DVA86_RS18515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18665"
                     /product="lasso peptide biosynthesis protein"
                     /protein_id="WP_208879765.1"
                     /sec_met_domain="PF13471 (E-value: 2.1e-10, bitscore: 39.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHAVRTRRRNEQAVRSIVLGDREPHPELSVRSAELPAAVRDYLR
                     FGRAFTSGGLPRVLAALPGPNVRKRARGGSGPATVFWARDAAWRAQGLARSLAGRHLCL
                     HEAIGVCAALRGLGFAVDIVIGYPTVESEHTEGELHAWPAIGDEPVIERSSGFEASHVE
                     LIRYPEPAGVVTSAGAVTSADAGAVCP"
     gene            10564..12450
                     /locus_tag="DVA86_RS18520"
                     /old_locus_tag="DVA86_18670"
     CDS             10564..12450
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="DVA86_RS18520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18670"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_208879766.1"
                     /sec_met_domain="Asn_synthase (E-value: 3.1e-09, bitscore:
                     35.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLTAFGMSGSISLAGADGRESDYRFSGTYGTDPRRDHDSAGIVL
                     MQGPVHDADVTGVQPDPSPPDTAAPPRVALTGWAAVPRDHSGPPDQPFAALQRALDERG
                     PESLRAVPGDYVAAHVAADRRRVVLCRPANAVTPLFWRADGDRLRWSTDPVDLLPAAGP
                     TLGDVDVDALPFIIAGVGMAGDRSWFRGVHRLAPGHLLEVSPGAGRRPVVRRYDQVAAT
                     DVPSDLDTAAEALRERLATACSRLVAGERTAMLLLSGGLDSAVVAHETADLSVRVTGMH
                     FTLDGFPGFAEDVAAAKSVAEAGNVRYLPFDMTEHARRGGGYLDAADSTGFPVTQVPLP
                     GLPAAAEHAEGIGARMLLSGLYADQVFSADHSTAVFAARGLGALNPTVAGEPVWQLLSR
                     AAGASFGGGEKRRFAVLRYLAGRASGRGDALLSTFGELPPAPWLSADAADAFQRAARDN
                     AERSLAAVRGDDGRRDFLARYSLQESLNAVTTQAGWINHCMPRRCMLTTPFLDRDVIEF
                     VLSLPSRHRTGVAYGRRLDKLVLRLAYGRRAGLLDTGLRMHQARIDAVPAVYTHQNFER
                     IRELLSPDALLCRLGIVDKTYPERLNRTTAHRDGEHFVRLAVIEKWLRRLPE"
     gene            12447..12731
                     /gene="adfB"
                     /locus_tag="DVA86_RS18525"
                     /old_locus_tag="DVA86_18675"
     CDS             12447..12731
                     /codon_start=1
                     /gene="adfB"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DVA86_RS18525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DVA86_18675"
                     /product="actinodefensin-associated protein B"
                     /protein_id="WP_208879768.1"
                     /transl_table=11
                     /translation="MSETRGVREPRDRELRLAGHVRFRELPFCGVLLDTEKSQVHRLSP
                     RAARVLRERLYGAGSTGPYASLITDEPADERTAEAIVTALERAGFVHRA"
     gene            complement(12786..>13424)
                     /locus_tag="DVA86_RS18530"
                     /old_locus_tag="DVA86_18680"
                     /pseudo=""
     CDS             complement(12786..>13424)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006130819.1"
                     /locus_tag="DVA86_RS18530"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18680"
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="ALAALVRLRAGDNLGPARTAADRLLHAPDEGPAGAGARTGGGVGA
                     GGSGGARAGISAPARGLDGLPAAWHEALASAYAAAAEPRYGPVAEWAAVGPYRLLTGLT
                     SLTGLTAPPPGGDAAEAPVRDGAAAPDPAVRRLLEPAHRELAGTAEVFLDRAGQAGRTA
                     AELGIHRQTLYYRLSRVEQLTGLDIHDGADRLLLHMSLKAARLTHSWPP"
     gene            complement(13572..13895)
                     /gene="cutA"
                     /locus_tag="DVA86_RS18535"
                     /old_locus_tag="DVA86_18685"
     CDS             complement(13572..13895)
                     /GO_process="GO:0010038 - response to metal ion [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cutA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970790.1"
                     /locus_tag="DVA86_RS18535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18685"
                     /product="divalent-cation tolerance protein CutA"
                     /protein_id="WP_208879769.1"
                     /transl_table=11
                     /translation="MTDFVQVSTATETRQQAVELARSAVRDRLAAGAQIIGPVTSVFWH
                     LGEFGESEEWQLLLKTSLTRYPALEEHLLEHHPWDNPELSAVPIAAGAERCLQWVRESV
                     EPA"
     gene            <14195..14443
                     /locus_tag="DVA86_RS18540"
                     /old_locus_tag="DVA86_18690"
                     /pseudo=""
     CDS             <14195..14443
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009062240.1"
                     /locus_tag="DVA86_RS18540"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18690"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="NAIESVNARIRKAVRARGHSPSEAAALRCIYTALMSLDATGTGRH
                     RWTMHGKTPPNAFQIASEGRLAPTSHWHLNNQDQPSS"
     misc_feature    14646..14660
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            14935..15576
                     /locus_tag="DVA86_RS18545"
                     /old_locus_tag="DVA86_18695"
     CDS             14935..15576
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075241.1"
                     /locus_tag="DVA86_RS18545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18695"
                     /product="restriction endonuclease"
                     /protein_id="WP_342776362.1"
                     /transl_table=11
                     /translation="MSVAGIAMVLVLVLLWSAVWPYVVGTVLAVGVGATGWWLWRTDRM
                     LRGGDRRWRQEEAVREGHRTLAEVDGMSGTEFEDLVAGLCRRDGCTEVRRVGGSHDNGA
                     DVVGRLPDGRAMVIQCKRYAPSSTIASRELRDLLGAKVHFGAEVAVFATTTRFSRPSEA
                     FAVEHGILAVHRDHLGLWNNGASLSSLISVNGSGQGDARHRARWKQAYGK"
     gene            <15810..>16002
                     /locus_tag="DVA86_RS35365"
                     /old_locus_tag="DVA86_18700"
                     /pseudo=""
     CDS             15810..>16002
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019074640.1"
                     /locus_tag="DVA86_RS35365"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="DVA86_18700"
                     /product="restriction endonuclease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDRDFEYALRDLLVRDGWMARRVGQQGDQAADVVGQDGRDA"
     misc_feature    15834..15836
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16150..17397)
                     /locus_tag="DVA86_RS18550"
                     /old_locus_tag="DVA86_18705"
     CDS             complement(16150..17397)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237583.1"
                     /locus_tag="DVA86_RS18550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18705"
                     /product="MFS transporter"
                     /protein_id="WP_245996766.1"
                     /transl_table=11
                     /translation="MRFSPTGPRLPRAVWLLIVARAVNRLGAFSLPFLAVLITTRFGAS
                     AATAGLVAAAFGLATIPSRLAGGRLADTLGRRRTMVVGLSGCALAQLGIAAADSLAAAA
                     CFAVLLGLVFELYEPPSQAMIADAVGPGERIRAYSLLNAALAVAGLGAGLIAAGLGRWD
                     LRWLFVADAVTCLICAAVVPVVLPADRPDAAGPAREGAKQVRPWRDGALLALLASGTLF
                     ALVYLQIMITLPLSLAHRDLQPADAGLLLAASAGVIVLGQPLLRLKRLAALSAPVAFTA
                     GYSLLALGLSGYALAHTLGAFLAATLVWSLGDLLLVGRMYAVVAELAPGGGTGRYMAVY
                     GTSWGIAGIAAPVTGTQLLQHSGATVLWGTMAGVCLALAAVQPVLARTATHRTRLASEV
                     AGPEAGAQGHRATRSP"
     gene            17490..18050
                     /locus_tag="DVA86_RS18555"
                     /old_locus_tag="DVA86_18710"
     CDS             17490..18050
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014151153.1"
                     /locus_tag="DVA86_RS18555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18710"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_245996767.1"
                     /transl_table=11
                     /translation="MVTLLEVTVSLVNTLTDGRQRGRPYTAPRGTDLPGAVAAALPPTS
                     PGPEEIDPEEAAHLAGTARQMKSVFEAVDEDRIDDAAAVINSLLRSTGARPQLDRVADE
                     PWQVHFHGADDSLAVGWSAGCATALALATGSDLAGRLGVCRAPECDRVYIDNSRNAVRQ
                     FCSSPCQSRVKAATFRARKAEQR"
     gene            complement(18237..18878)
                     /gene="merB"
                     /locus_tag="DVA86_RS18560"
                     /old_locus_tag="DVA86_18715"
     CDS             complement(18237..18878)
                     /GO_process="GO:0018942 - organometal metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="merB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325361.1"
                     /locus_tag="DVA86_RS18560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18715"
                     /product="organomercurial lyase MerB"
                     /protein_id="WP_208879771.1"
                     /transl_table=11
                     /translation="MNTDTEELATRFSDTVNRAPGVKLWLLRPLLRLLATGEPVTLDQL
                     AAQADRTTEEIRAALADMPDTEYDTAGHIIGDGLTHNPTPHRYQTDSHTLYAWCAMDTL
                     VFPAVIGHIAQVASPCAVTGEPVHLTVTPDGPTDVEPATAVVSLVAPDAPTSVRAAFCN
                     KVHFFASADAATDWLTHHPDAQVVPVADAYEIGRPIVEQMLSGNTSSGCC"
     gene            complement(18958..19395)
                     /locus_tag="DVA86_RS18565"
                     /old_locus_tag="DVA86_18720"
     CDS             complement(18958..19395)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491876.1"
                     /locus_tag="DVA86_RS18565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18720"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_245996769.1"
                     /transl_table=11
                     /translation="MNTHRPGRRTRAMTVGDLSRQTGVTVKALREYTDLGLIYTLGRSP
                     ANYRLYDTDALWCVRFIGELRGLGLTVAEIRDLTTAYLDSPDRPVGSHLAELLHRSRER
                     LRQRITAQQQILDRIDEFETEHQHHLEEGDLCWAGDPRCEA"
     gene            complement(19424..20863)
                     /gene="merA"
                     /locus_tag="DVA86_RS18570"
                     /old_locus_tag="DVA86_18725"
     CDS             complement(19424..20863)
                     /EC_number="1.16.1.1"
                     /GO_function="GO:0016152 - mercury (II) reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="merA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325362.1"
                     /locus_tag="DVA86_RS18570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18725"
                     /product="mercury(II) reductase"
                     /protein_id="WP_208879772.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.3e-59, bitscore:
                     200.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTHSGFDLAVIGSGSAAFAAAIAATNQGKRVAMIERGTTGGTC
                     VNVGCIPSKALLAAAEARHGCGAAGRFPGLAAAELPVEFRQLIDGKDALVEQLRAEKYT
                     ELAADYGWEIVHGTATFSGTSDAPALEVSLRDGGTRRIEAAHYLVATGSAPWAPPVEGL
                     AEAGYLTSTTAMELDALPESMIVVGGNAVGLEQAQLFARLGTQVTVIEALEQLAPFEEP
                     EVSSVIEDVFAEEGVTVHTGATLASVRTEDGAKIAAVRTRSGRETELRTETLLVATGRR
                     PVISGLGLDAVGVKTGERGDVVVDDHQRTTNERIWAAGDVAGGPQFVYVAAAQGTLAAD
                     NAFADAERTLDYTALPRVTFTSPAMAAVGMTDAQAADAGIPCDCRVLPLEYVPRALANR
                     DTRGLVKLVANAETGRVLGVHVIADGAGDIITAATYAITAGMTVDQLAHTWAPYLTMAE
                     ALKLAAQTYTADVARLSCCAG"
     misc_feature    complement(20908..20925)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            20985..21368
                     /locus_tag="DVA86_RS18575"
                     /old_locus_tag="DVA86_18730"
     CDS             20985..21368
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007504879.1"
                     /locus_tag="DVA86_RS18575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18730"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_208879773.1"
                     /transl_table=11
                     /translation="MPQRLSTPTGVASPAADEVPCTHLDTVAKFFRALADPTRLKLLEF
                     ILRGERTSAECVEHAGISQPRVSVHLSCLVDCGYVTARRDGKKLRYSVGDPRVADLLVL
                     ARSLAADNATALTCCTRIPDGPG"
     gene            complement(21861..22157)
                     /locus_tag="DVA86_RS18580"
                     /old_locus_tag="DVA86_18735"
     CDS             complement(21861..22157)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024940.4"
                     /locus_tag="DVA86_RS18580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DVA86_18735"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_208879774.1"
                     /transl_table=11
                     /translation="MLACAEGTSNRHVAARLGTSVSTVTRWRRRFVESWLEGPTDGLRP
                     GRPLPVLNDRVEAVVVATLETSPPNATHCSRASMALAPVCRGRRSDGPGRSSS"
     misc_feature    22303..22318
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 23.11"
                     /tool="antismash"
     misc_feature    complement(22303..22319)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: medium, score: 28.54"
                     /tool="antismash"
     misc_feature    complement(22304..22319)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: strong, score: 32.38"
                     /tool="antismash"
ORIGIN
        1 accgtatccg cgagatcgcg gaccggctcc ggctcacgct gtccgagccg taccgcgtgg
       61 agggcaacga gatgcgggtc gccgcgtcca tcggcgtagc cttcgccgag ccgggcatct
      121 ccccggccga cctgctgcgc aacgccgatc tggcgatgta ccgcgccaaa caggccggca
      181 aggcgcgggt ggagctctac gccccgcaga tgcagacgga cgtggcccaa cggaccgagc
      241 gggcggacca gttgcgcggg gcgctgcacc gcggcgagtt cgcgctgctc caccagccca
      301 tcgtcgagct gggcaatggg accgtcaccg gcgtcgccgc gcagccgcgc tggcggtcgg
      361 cgcagggcat cctcttcacg cccgccgagt tcctccgtgc cgacggccgc gccggcggcc
      421 gcgccggcgg cgagccgcag ggcgaccggg cggccgagat gagccgctgg ctgctggagg
      481 aggcggtctc gcaggccgcc gcccggcacc gcgcggggat agaggcgccg gtgaccgtac
      541 ggctgtcggc ggggcgcgtc acggaccgct cgctggcgct caaccgcgtc gaggagctgc
      601 tcggccggca cgggctgccg cccggctcgc tcatcctgga gctgtccgac agcgacccgc
      661 gcataccgct ggacgagctg gagcagcggc tgaacgccct gcgcaagctc ggcgtgcgca
      721 tcgccctgga cgggttcggc agcgggtacg ccgcgatggc cgcgctccgg cggctgccgc
      781 tggacatcct ctgcctcgac cggggcctgg tggacggcat cgccgagtcc gtacggctgc
      841 gcaagatcac cgccgggttg ctgcgtatcg caggcgacct cgggctcatg tccatcgcgg
      901 acggcgtgga cctgcccgat caggtcacgg tgctgcgcgc gatgggctgc acgcacggcc
      961 agggcgcggc gttctccggc gcgctggacg agcaccggct gcgccgggcg ctggcccgcg
     1021 gcggcttccc cgtgcccggc gacgggccgg cgcccgccgg cgcggaccgg gccgccgcgg
     1081 accgctccac gtccgaccgc gccgccgccg gcccagccgc cgaccgcccc gcgcccgaac
     1141 gggccggtgc cgaacgggtg gcggcggacc gggtggccgc cgagcgcgcg gcgggcagcc
     1201 gttcggtcgt ggtggcggga tcgctgccgg tcaggcgcgg gggagtgtcc gggcccgacc
     1261 ctgtgacaca tcccccattg cgctcaaata gtgagacgac tgtcccaccc acttgacacc
     1321 ctgtggcctg ccggaggaag gtcagtgcca tgcgcacccg aattctcgta cttggacagc
     1381 gcgtctgctg accgggaccc catgaagtcc cgcgtcccca gcggcgcgct cccctcgctt
     1441 gccatccggc acggggggtt ttttgttgca ccagcactcg agcaccaccc gctatccaga
     1501 ccgcagaccg cgcgaaacga gcgtcaaccg cgcgctacga gcgtcaaccc tcactctccg
     1561 agaagagaca gacgatgacc gagcaggcca ccggggcccc taaaccgcag ccgcgggccc
     1621 gaaacggcgg gcatcagcag cccgccactg tcgaacacat gacgggcgcc cagtccctca
     1681 tccgttctct cgaggaagtc ggcgccgaca ccgtattcgg cattccgggc ggcgcgatcc
     1741 tgcccgcgta cgaccccatg atggactcca cgacggtccg ccacgtcctc gtgcggcacg
     1801 agcagggtgc gggccacgcg gcgaccggtt acgcgcaggc caccggcaag gtcggggtgt
     1861 gcatggccac ttcgggcccc ggtgcgacca acctcgtcac ccccatcgcc gacgcgcaca
     1921 tggactccgt gcccctcgtc gccatcaccg gccaggtggc gtcggccgcg atcggcaccg
     1981 acgcgttcca ggaagccgac atctgcggca tctccatgcc catcaccaag cacaacttcc
     2041 tggtcacgga cgcggcggag atcccccgta cgatcgccga ggcgttccac atcgcctcca
     2101 ccggacgtcc gggcccggtc ctcgtggaca tcgccaagga cgcgctccag acccgtacgg
     2161 ccttctcctg gccgccgcag caggacctcc ccggctaccg cccggtcacc aagccgcacg
     2221 ccaagcagat ccgggaggcc gcgaagctga tcgccgcggc cgagcgcccc gtgctctacg
     2281 tcggcggcgg cgtgctcaag gcgcggtcca ccgccgagtt gaaggtcctc gccgagctga
     2341 cccgcgcgcc cgtgacgacg accctgatgg gcatcggcgc gttccccgac agccacccgc
     2401 agcatctggg catgcccggc atgcacggca cggtcgccgc cgtcaccgcg ctccagaagg
     2461 ccgacctgat cgtggcgctg ggcgcccgct tcgacgaccg ggtgaccggg aagctggact
     2521 cgttcgcgcc gtacgcgaag atcgtgcacg ccgacgtcga cccggccgag atcggcaaga
     2581 accgggccgc cgacgtgccg atcgtcggtg acgcccgcga ggtcatcgcg gacctggtgg
     2641 tcgcggtgca ggcggagtac gaggcgcgcc gcggcgaaga gggcgcaccc gacgggtacc
     2701 aggagtggtg gaaccagctg aaccgctggc gggagacgta ccccctgggc tacgacctgc
     2761 ccgacgacgg ctccctctcg ccccagcagg tcatcgagcg catcggccag ctcgccccgg
     2821 agggcaccgt gtacgcggcg ggcgtcggcc aacaccagat gtgggcggcg cactacatcc
     2881 gctacgagca acccgccacg tggctcaact ccggcggtct cggcaccatg ggctacgcgg
     2941 tgccggccgc gctgggcgcg aaggtgggcg tgccggaccg tacggtctgg gcgatcgacg
     3001 gcgacggctg cttccagatg accaaccagg agctggtgac cgccgcgctg aacaacatcc
     3061 ccatcaaggt cgggatcatc aacaacggcg ccctcggcat ggtccgccag tggcagacgc
     3121 tcttctacaa ccagcggtac tccaacaccg tgctgcacgc cggcccggag gcggacggca
     3181 agaccccgtc ccacggcacc cgcgtccccg acttcgtgaa gctggccgag gccatgggct
     3241 gcgtcggcat ccgctgcgag gacccggagc agctggacgc ggtgatcgag aaggcgaact
     3301 cgatcaacga ccgccccgtc gtcgtcgact tcatcgtgca cgaggacgcg atggtctggc
     3361 cgatggtcgc ggcaggcacc tccaacgacg aggtcatggc ggcgcgcggc gtccggccgg
     3421 acttcggcga cagcgacgac tgaggaacgg agacaccgtc agatgtccaa gcacacactc
     3481 tccgtcctgg tggagaacac gccggggatc ctggccagga tcgcggcgct gttctcccgg
     3541 cgcgggttca acatcgactc gctggccgtc ggcgtcaccg agcaccccga catctcgcgc
     3601 atcaccatcg tggtgaacgt cgaggacctg ccgctggagc aggtcacgaa gcagctcaac
     3661 aagcttgtca acgtgctgaa gatcgtcgag ctggagcccg gcggcgccgt ccagcgtgaa
     3721 ctcgttctgg tgaaagtccg ggcggacaac gcgacccgct cccagatcgt cgagatcgtc
     3781 cagctcttcc gcgccaagac cgtcgacgtg tcgccggagg ccgtgaccat cgaggccacg
     3841 ggcggcagtg acaagctcga ggcgatgctg aagatgctcg agccgtacgg gatcaaggaa
     3901 ctggtccagt ccggcacgat cgccataggg cgcggggccc gttccatcac cgaccggtcc
     3961 ctgcgggcgc tcgaccggag cgcctgagac tcccggctca ttccgaacac cgctcgccat
     4021 acggtgggca gcaccacatc tgaaacaagg agatttgcga agtggccgag ctgttctatg
     4081 acaatgacgc cgacctgtcg atcatccagg gccgcaaggt ggccgtcctg gggtacggca
     4141 gccagggtca cgcgcacgcg ctgtcgctgc gcgactcggg cgtcgatgtg cgggtgggcc
     4201 tgcacgaggg ctccaagtcg cgggtgaagg ccgaggagca gggcctgcgc gtggtcacgc
     4261 ccgccgaagc ggtcacggaa gccgacgtga tcatggtgct ggtgccggac ccgatccagg
     4321 cgaaggtgta cgaggagtcg atcgcgccgc acctcaagga cggcgacgcg ctgttcttcg
     4381 ggcacgggct gaacatccgc ttcggcttca tcgcgccctc ggcgggcgtg gacgtgtgca
     4441 tggtggcgcc gaagggcccg gggcacctgg tgcggcggca gtacgaggag gggcgcggcg
     4501 tgccgtgcat cgccgcggtc gagcaggacg cgacgggcaa ggcgttcgcg ctggccctct
     4561 cgtacgcgaa ggcgatcggc ggcacccggg cgggcgtcat caagacgacg ttcaccgagg
     4621 agaccgagac cgacctgttc ggtgagcagg cggtgctgtg cggcggcacg acggcgctgg
     4681 tgaaggcggc cttcgagacg ctggtcgagg cgggctacca gccggagatc gcgtacttcg
     4741 agtgcctgca cgagctgaag ctcatcgtgg acctgatgta cgagggcggc ctggagaaga
     4801 tgcgctggtc cgtgtcggag accgcggagt ggggcgacta cgtcaccggc ccgcggatcg
     4861 tgaacgacca gaccaaggcc gagatgcggc aggtgctcgc ggagatccag gacggttcgt
     4921 tcgcgaacaa ctggatgaag gagtacaacg ccggtctgcc gaagtacaac gagtacaaga
     4981 aggccgacga ggaccacctg ctggagacca ccggcaggaa gctgcggaag ctgatgagct
     5041 gggtcgacga ggacaagtag gcggtggcac gcccggcgcg ggccgcactc ggatcaccga
     5101 cggcccgggt gcggcccgcg ccgggaccat gccacgcccg ctcggcggat ccgccggacc
     5161 gccggtgcgc ccttccgctg gtggatacac tgcaggacat acgcgtcaca ggctcacagc
     5221 gtcgtgcgtc tccacgcggc tgccaaccgt ccaccgcctt cggccgtcgg gacgcggccg
     5281 tttctccccg tagctctgcc agcacgggcg gcgcccccag gacaagtgag gactgagacc
     5341 caagtgagca agcccgtagt actcatcgcc gaagagctgt cgcccgccac ggtggacgcg
     5401 ctcggtccgg acttcgagat ccgccagtgc aatggcgccg accgggcaga gctcctcgcc
     5461 gccatcgcgg acgtcgacgc catcctcgtg cgcagcgcga ccaaggtgga cgccgaggcc
     5521 gtggcggctg cccgcaagct caaggtcgtc gcccgcgcgg gcgtcggcct cgacaacgtc
     5581 gacgtgcccg cggccaccaa ggcgggcgtc atggtcgtca acgcgcccac gtccaacatc
     5641 gtgaccgccg ccgagctcgc ctgcggcctg ctggtcgcct cggcccggaa catcccgcag
     5701 gccaactcgg cgctgaagaa cggcgagtgg aagcgcagca agtacacggg cgtcgagctg
     5761 tccgagaaga cgctcggcgt cgtcggcctc ggccgcatcg gggtgctggt cgcgcagcgg
     5821 atgtcggcgt tcggcatgaa ggtggtggcg tacgacccgt tcgtacagcc cgcccgtgcc
     5881 gcccagatgg gcgtgaagct gctgtcgctg gacgagctgc tggaggtctc ggacttcatc
     5941 accgtgcacc tgccgaagac gcccgagacg ctggggctga tcggtgacga ggcgctgcac
     6001 aaggtgaagc cgagcgtccg gatcgtgaac gcggcccgtg gcggcatcgt ggacgaggag
     6061 gcgctggctg cggcgctcaa ggagggccgt gtcgcgggcg cgggcctgga cgtctacgcc
     6121 accgaaccgt gcacggactc cccgctgttc gagttcgacc aggtcgtgtg caccccgcac
     6181 ctgggtgcct cgaccggcga ggcgcaggag aaggccggca tctcggtggc caagtccgtc
     6241 cgcctcgcgc tggcgggcga gctggtgccg gacgcggtga acgtacaggg cggcgtgatc
     6301 gccgaggacg tacggcctgc gctgccgctc gcggagaggc tgggccgtat cttcaccgcg
     6361 ctggcgggcg aggtcgcggt gcggctcgat gtcgaggtgt acggcgagat cacccagtac
     6421 gacgtgaagg tgctcgaact ctccgcgctc aagggcgtgt tcgaggacgt cgtggacgac
     6481 acggtgtcgt acgtcaacgc gccgctgttc gcccaggagc gcggcgtcga ggtgcggctg
     6541 acgacctcca gcgagtcgcc cgagcaccgc aacgtcgtga tcgtgcgcgg caccctcggc
     6601 accggcgagg aggtgtcggt gtccggcacc ctgagcggcc cgcggcacca gcagaagatc
     6661 gttgccgtcg gcgagcacga cgtggacctg gcgctcgcgg accacatggc cttcctgcgc
     6721 tacgccgacc gccccggcgt ggtcggccag gtcggccgca tcctcggcga gacgggcatc
     6781 aacatcgcgg gcatgcaggt ctcccgggcg acggtgggcg gcgaggccct ggtggcgctc
     6841 accgtggacg acacgattcc ggcggcggtg ctgacggaga tcgcgggcga gatcggcgcg
     6901 acctcagccc gcagcgtgaa cctggagggc tgactgcggc ggcggccgcg gccgctgtcg
     6961 tacgggcccg gaccggcgct tcgtcgcctg gtccgggccc tttcgcgtgc ccggacccgc
     7021 atgtggggga gcggcgcgac ttcgctatca cttcccttca gatggatgaa atctctccgc
     7081 ttagccctta gcgtcgtatg tagacggagg aaattcatcc acctgcacaa ccgtgtggga
     7141 ctgaccggag gtgtggaatg cgcgcggacg cccagcacaa ccgcgaacag atcctgcggg
     7201 ccgcccgaca gatcttcgtc cacgagggcc cggacgcgcc gctcgacgtg atcgcccggc
     7261 gcgcgggcgt cggcgtcgcc acgctctacc gccgcttccc gacccgggac gacctgatcc
     7321 gggccgtcgc ggccgacacg ctggagctgc tgtacgaggg ggtcacccgg gccgcggcgg
     7381 aggagggcga cccgttcgag gcgctgcggc gcttcatgca cgcggccctc gacctcaaca
     7441 tcggcgcggt gatgccgtcg ctgttcggcc ggttcgaggc ggaccgcgtc ctcagcgagg
     7501 tgcgcgacgc cgtcgatccg ctgcacgacc tgatgtccag ggcccaggag gcggcgctgc
     7561 tgcgcgcgga cgcggctccc ggcgatgtca tctttatgat catccggctg acccggccgc
     7621 tgcccggcgg cggcttcccc gaggacggcg ccctcgcgca ccgccagctc gagatctaca
     7681 tcgacggact gcgcccgtcc gccgcctggc cgcgcgagga acggctgccg gggccggcga
     7741 tcggcgtccc ctggttccgg cgcatccgcg cacggatggc gaaggggatg gccggggtgg
     7801 agggtggcga gcgcgacagt ccctcgtagc gcaccacccc ctcgtagtgc ccccgcccgc
     7861 tgcgcactcc gcgccacccg cgcccgcgcc actcgcgcgt tccgcgcccg cgccgccggc
     7921 tgccgctgac gccaccgctt acggcggcgg ctcgaaccgc aagaccgcaa gagggagtaa
     7981 ctgtcatggc cacaacaact ccggcgccca tccccagtgc cgcggagagc aacccgcgcc
     8041 gctggctcgc gctcgtcttc atcgggctcg cgcagctgat gatcgtgctc gacatcacga
     8101 tcgtgaacat cgcgctgccc tcggcccagc aggacctggg catctccagc ggcgaccgcc
     8161 agtgggtcat caccgcgtac accctgtcgt tcggcagcct gctgctcctc ggcggccgta
     8221 tcgccgacta cacggggcgc cgccgcgcct tcctcatcgg gctgctcggc ttcgcgggcg
     8281 cgagcgcgct cggcggagcc gcggccaact tcggcatgct gctcgccgcc cgtacgctgc
     8341 agggcgtctt cgccgccctg ctcgccccgg ccgcgctctc cctgctcacc gtcagcttca
     8401 ccgaggcacg cgaacgcgcc aaggcgttcg gcgtgttcgg cgccattgcc gccggcggcg
     8461 gcgcggtggg gctggtcgtc ggcgggctgc tcaccgagta cctggactgg cgctggtgcc
     8521 tgtacgtgaa cgtgccgatc gccgtcatcg ccgcactcgg ctggaccgcg ctccccgccg
     8581 accagcgctc cgccacccgg caccgcatcg acgtacccgg cgtactgctc gccgtcaccg
     8641 gcctggtcgc cgtcgtctac ggctgcagcg aggccgagtc cgagggctgg gactcccaac
     8701 tcgtcgtcgg gctgctgtcg gtgggcatcg tgctgctcgt ctcgttcgtg ctctacgagg
     8761 gccgccgcgc cgaacgcccc ctgctgccgc tgcgcgtcat cgccgaccgg gcgcggggca
     8821 gcgcctatct ggcggtggcg ctgtcggtcg tcgccatgtt cggcatgttc ctgttcctca
     8881 cctactacat gcaggtcgtc aaggactact cggcggtgct caccggcgtc gcgttcctgc
     8941 ccctcaccgc gggcgtactg ctctccgctg gcggcatcgc ctcccggctg ctgccgaggg
     9001 tcgcaccgcg gctgctggtg gtgccggggc tgctgaccac cgccagcggc accctgtggc
     9061 tcgtcttcct ggaggcggac acgtcgtacg ccaccggggt gctgcccgcc gagatcctgg
     9121 tcggcctcgg gatgggcctg gtgatggcgc cggcgatgaa ctacgccacc cacggcgtgc
     9181 gcccggagga cgccggcatc gcgtccgcca ccgtcaacac ctcgcagcag atcggcggtt
     9241 cgatcggcac ggcgctgctc aacaccatcg ccaccagcac gaccagcgac tacctcgcgg
     9301 accgacccaa ggcgccgccc gtgctgcggg acgggctggt cgaggggttc tcggcggcgt
     9361 acgcggtggc gaccgccatc ctggtggccg cggcgatcgc cgtcggcctg ctgatgaaca
     9421 ccccgcggcc gcggcgcgag tccggcccgg cgcaggacgc gcccgcggcg gtgcacctgg
     9481 gctgagaggg tcgcagaccc ccgggccccg ccgccggttg ccgccggcgg cggggccttc
     9541 ggctgccctg ccggctcaac ggtcgcgggg gcagcgcccg ttggcccgct ctaggggatg
     9601 cactagggcc ccgctgttac gttgatcgtc cgatgccgga tggcatcgat ttcaagtccc
     9661 cgacggggaa aggtgtgaac atggacaagc agctcgaaga cgccactctg gaagcggtgg
     9721 aatcggccga catcgagttc gtggggagcc tcgaggacgt cacacacggc gcggccctcg
     9781 cccccaactt cgagtccatc gcggggctgt gctggtgctg acccagccgc tccggcggtc
     9841 gtccccactc tgagacgccg ctgaacgggc cggtgccggt gccccgagcc gtcggccggc
     9901 gccggccctc tccccgtctc ctcttccact gtttccccgt cccggagagt cgagcgaagt
     9961 gaaacatttc agcgggcctc acgacggtgt cctcgcggag ttgcgacacg cggtacgcac
    10021 gcgtcggcgc aacgaacagg cggtcaggtc gatcgtcctg ggcgaccggg agccccatcc
    10081 ggaactgtcc gtgcggtcgg cggagttgcc cgccgccgta cgcgactacc tgcggttcgg
    10141 gcgcgcgttc acgtccggcg gtcttccgcg tgtcctcgcc gcgctgcccg ggccgaacgt
    10201 gcgcaagcgg gcacgcggcg gttccggtcc cgccacggtg ttctgggcgc gtgacgcggc
    10261 ctggcgggcc caggggctcg cccggtcgct cgccggccgg catctctgcc tgcacgaggc
    10321 catcggggtc tgcgccgcgc tgcgcgggct tggcttcgcc gtcgacatcg tcatcggcta
    10381 tcccaccgtc gagtccgagc acaccgaggg tgagttgcac gcctggcccg ccatcggtga
    10441 cgagccggtg atcgagcgct ccagcgggtt cgaagcgagc cacgtggaac tcatccgtta
    10501 tccggaaccg gcgggggtgg tcacgagtgc gggcgcggtc acgagtgcgg atgcgggcgc
    10561 ggtatgcccc tgaccgcgtt cggcatgtcc ggcagcatct cccttgcggg agcggacgga
    10621 agggagtccg actaccgctt ctccggcaca tacggcaccg acccccgccg agaccacgac
    10681 agcgctggaa tcgtcctcat gcaggggccg gtgcacgacg ccgacgttac gggggtgcag
    10741 cccgatccgt cgccgcccga taccgcggca ccgccccgtg tggcgctcac cggctgggcc
    10801 gccgtaccgc gtgaccacag cggaccaccg gaccagccct tcgccgcgct gcagcgcgcg
    10861 ctggacgagc ggggccccga atcgttgcgc gcggtgccgg gcgactacgt cgccgcccat
    10921 gtcgccgccg accgccgccg cgtcgtcctc tgccgccccg cgaacgccgt caccccgctc
    10981 ttctggcggg ccgacggcga ccgcctgcgg tggtcgaccg acccggtcga cctgctgccg
    11041 gccgccgggc cgacgctggg cgatgtggac gtggacgcgc ttccgttcat catcgccggg
    11101 gtcggcatgg ccggtgaccg gtcctggttc cggggcgtgc accggctggc accaggccac
    11161 ttgctggagg tgtcccccgg ggccggccgc cggcccgtcg tccgccgcta cgaccaagtc
    11221 gcggccaccg acgtgccgtc cgacctggac accgcggccg aggcgctgcg ggagcgtctc
    11281 gcgacagcct gctcccgcct ggtcgcgggc gagcgtacgg cgatgctgct gctcagcggt
    11341 gggctcgact cggccgtcgt ggcgcacgag acggcggacc tgtccgtacg ggtcaccggc
    11401 atgcacttca cgctcgacgg cttccccggg ttcgcggagg acgtcgccgc cgccaagtcg
    11461 gtcgcggagg ccggcaacgt gcgctacctg ccgttcgata tgacggagca cgcccggcgc
    11521 ggcggcggct atctcgacgc cgccgacagc acggggttcc ccgtcacaca ggtgccgctg
    11581 ccggggcttc ccgccgcggc ggagcacgcg gagggcatcg gggcgcggat gctcctctcc
    11641 ggcctgtacg cggaccaggt gttctccgcc gaccacagca ccgccgtctt cgcggcccgc
    11701 ggcctcgggg cgctgaaccc caccgtcgcg ggcgaacccg tatggcagtt gctgtcgcgc
    11761 gcggcgggtg cctcgttcgg cggcggtgag aagcgccggt tcgcggtgct gcggtatctc
    11821 gccgggcggg cgagcgggcg cggcgacgcg ctgctgtcca cattcggcga actgccgccc
    11881 gcgccctggc tgtccgcgga cgccgccgac gcgttccagc gggcggcgcg cgacaacgcc
    11941 gagcgctcgc tggcggccgt ccgcggcgac gacgggcgcc gcgacttcct cgcccgctac
    12001 tccctgcagg aatccctgaa cgccgttacc acgcaggccg gctggatcaa ccactgcatg
    12061 ccgcgccgct gcatgctcac cacacccttc ctggaccggg acgtgatcga gttcgtgctg
    12121 agcctgccga gccggcaccg tacgggcgtc gcgtacgggc gccggctcga caagctggtg
    12181 ctgcgcctgg cgtacgggcg ccgggccggg ctgcttgaca cgggactgcg gatgcatcag
    12241 gcccgcatcg acgcggtgcc tgccgtctac acgcatcaga acttcgagcg gatccgggaa
    12301 ctcctgagcc ccgacgcgct gctgtgccgg ctcggcatcg tcgacaagac ctatccggag
    12361 cggctgaacc gtacgactgc ccaccgcgac ggtgagcact tcgtacggct cgccgtcatc
    12421 gagaagtggc tgcggaggct gccggaatga gcgagacacg gggtgtgcgg gagccacggg
    12481 accgggaact gcggctggcc gggcacgtgc gattccggga actgccgttc tgcggagtgc
    12541 tgctggacac cgagaagtcg caggtgcacc ggctctcccc gcgcgccgcg cgggtgctgc
    12601 gcgagcgctt gtacggcgcg ggcagcaccg gcccgtacgc gtccctgatc acggacgagc
    12661 ccgccgacga gcggaccgcg gaggccatcg tcacggcgct cgaacgggcg ggcttcgtcc
    12721 accgggcgtg agccggctcc gtccaccaga tgtgggccgg cgcgcgcggg ccggcgcgcg
    12781 ccggctcacg gcggccagct gtgggtgagg cgggccgcct tcagggacat gtggaggagc
    12841 aggcggtcgg cgccgtcgtg gatgtcgagg cccgtgagct gctcgacacg ggacagccgg
    12901 tagtagagcg tctgccggtg gatgcccaac tccgcggccg tacgccccgc ctggcccgcg
    12961 cggtcgagga acacctcggc ggtgcccgca agttcacggt gcgcgggctc cagcaggcgg
    13021 cggacggccg ggtcgggtgc cgccgcgccg tcccgtacgg gtgcctccgc ggcgtcgccg
    13081 ccgggcggcg gggcggtcag gccggtcagg gacgtgaggc cggtcagcag ccggtacggt
    13141 ccgacggccg cccactcggc gaccggaccg taccgcggct ccgccgcggc ggcgtacgcc
    13201 gaggccagcg cctcgtgcca ggccgcgggc agtccgtcca ggccgcgcgc cggcgcgctg
    13261 atccccgcgc gggcgccccc gctcccgccc gcacccacgc ccccgccggt acgcgcgccc
    13321 gcccccgcgg gcccctcgtc cggtgcgtgc agcagccggt ccgcggccgt acgggcgggc
    13381 ccgaggttgt cgcccgcccg cagccgtacg agcgcagcca gcgccggccg ccgcccccgc
    13441 gccgcggccc acgtggtcgt cgatgaacac gtacagtgcc gccagaaggg cgtccaggtt
    13501 tgtcttcaca cactgaccaa cgggcgccct tcgccatggt cgcgaccagc accgacatcg
    13561 gactcattca tctaggcggg ttcgaccgat tcacgcaccc actgaaggca cctctccgct
    13621 cccgccgcga tcggcacggc ggacagctcg gggttgtccc acggatgatg ctcaagcaga
    13681 tgctcctcca gggccgggta ccgcgtgagg ctggtcttca ggagaagctg ccactcctcg
    13741 ctctcgccga actcgcccag atgccagaag accgaggtga caggcccgat gatctgagct
    13801 ccggcggcga ggcgatcacg tacagcggac cgtgccaact cgaccgcctg ctgccgggtt
    13861 tcagtggctg tcgacacctg cacaaagtca gtcatggcga agatgctatt cgggggagca
    13921 gagatcgtcg ccagccgggc cctagtcagt accggttggc cctcacctcg ccgagtggag
    13981 ggccgtcgcc atgcgcggcc ggtcgtcccg tcgcaccctg gccgcatgga gcgcgcccgc
    14041 atcgtcgtct gcctgccgtc cccgaccacg gccgtccgtc gaggacggcg ggcaggccat
    14101 cggcgtcgcc cacaagagtt gctgcgccgg gtcggcctcg accggcgccg tgcggctgga
    14161 cgaccccgcc ctgatcgagt ggcgcggggg tgggaacgcg atcgagagcg taaacgcccg
    14221 tatccgcaag gcggttcgtg cccgcggcca ctccccctcg gaggcagccg cgctgaggtg
    14281 catctacacg gcgttgatga gcctggacgc gaccggcacg ggccgacacc gctggacgat
    14341 gcacgggaaa acaccgccga atgccttcca gatcgcctcc gaaggccgcc tggcccccac
    14401 cagccactgg cacctcaaca accaagatca gccgtcaagt tgacacaccc ggtgccaggc
    14461 attgaggcgc acatcatcat cttcctgccg ctacgccgcc gcacgtaggc ccgaagccgc
    14521 tccgatgagc aactgaccgt cgtcatcatg ctggtgttcg gcgtgctggt cgccccgacc
    14581 agctctggtc agtggattct ggacaccgac catgtgccag tgacggccgt gcgtgtcagc
    14641 ggggtaacag ctttgtcgat cggtcgggtg tcctggtctg ccaggaagca gccgtgagtc
    14701 cggggccatg tacgggcctg gagaaaggcg aactcgacca cggatgagac caggggcccc
    14761 atggggctgc ctggtcacag gcctttcata cgtggctgag aggcgctctt tccgagccct
    14821 tctccgggtg cccagactgc ttcggaggcg cggtgggcga agggggctgg gatggcatct
    14881 cgaaggggac ggcgatcggt cgcgcgaagg cgacgggata ctcgcatcag ggcggtgtca
    14941 gttgccggga tcgcgatggt gctcgtcctt gtgctgctct ggtctgcggt ctggccgtac
    15001 gtcgtgggga ctgttctggc cgttggcgtc ggtgcgacgg gctggtggct gtggcgtacg
    15061 gaccgcatgc tgcgcggcgg tgaccgtcgc tggcgtcagg aggaggcggt gcgggagggc
    15121 caccgcactc tggctgaagt ggacgggatg agcggcacgg agttcgagga tctggtggcc
    15181 ggcctgtgcc gtcgcgacgg gtgcacggag gtccgccggg tgggcggttc gcacgacaac
    15241 ggcgccgatg tcgtggggcg ccttccggac ggccgtgcca tggtcatcca gtgcaagcga
    15301 tatgcaccga gcagcacgat cgcgagccgc gagctccgtg acctactggg cgccaaggtg
    15361 cacttcgggg ccgaggtggc cgtcttcgcg acgacgaccc ggttcagccg cccctccgag
    15421 gcgttcgcag tggaacacgg catcctcgcg gtgcaccgcg accatctggg gctctggaac
    15481 aacggcgcct ccttgtcgtc gttgatcagc gtcaacggct ccgggcaagg cgacgcccgt
    15541 catagagcgc gctggaaaca ggcctacggc aagtgagtcc tccacccccc gtattgaggc
    15601 ccgctggagg cggctggact acctgtactt gcgatcgaac acctgctgta tgcggacatc
    15661 cgtaacttct ctcggggttg acgactcgca cctgccctga ggggggtgaa cacgccgtgc
    15721 tccagggctg gtttaggcac cacaggtcgc tgttgcccta gcggctggac gatcgcggcc
    15781 gtggccgcgg gagcacggtt gtgcggtcag acgaccggga cttcgagtac gccttacggg
    15841 atctactcgt ccgcgatggc tggatggcgc gcagggtagg gcagcaaggt gatcaagccg
    15901 ctgacgtcgt cgggcaggac ggccgggacg cgtaatcgtc caggccaaac acaccaaggt
    15961 gtcgtggacg aggtcggctc ccacgtgatg tatcagctca aatgaaccgc cgagcccgtc
    16021 catagagcgg acttcgcagt cgtcgtcact aacggatcgc agctacgggc tggctgtccg
    16081 gcaagcctcc tcgcatccga agcacagggg atcggtcaac tcagcccggc cgacgtgccg
    16141 atgaccgcgt cacggggaac gagtggccct gtggccctgc gcaccggcct cgggtcccgc
    16201 cacctcggag gccaaccgtg tgcggtgggt cgccgtacgg gcgaggacgg gctgaacggc
    16261 cgccagagcg aggcagacgc ccgccatagt cccccacaag acggtcgccc cggaatgctg
    16321 aaggagttgg gtgccggtga cgggcgcggc gataccggcg atcccccaac tcgtgccgta
    16381 gacggccatg taccgcccgg tgccgccgcc cggcgccagc tccgcgacga ccgcgtacat
    16441 ccgtcccacc agcagcaggt cgcccaggct ccatacgagg gttgccgcga ggaaggctcc
    16501 cagggtgtgc gcgagggcgt agccggacag gccgagcgcg agcaaggagt agcccgcggt
    16561 gaaggcgacg ggggccgaaa gggcagccag ccgtttcagg cgcaggagtg gctggccaag
    16621 cacgatgact ccagcggacg cggccaggag gagcccggcg tcggccggtt gcaggtcacg
    16681 gtgcgccagg gacagcggaa gcgtgatcat gatctggagg tagaccagag cgaacagggt
    16741 tcccgaggcg agcagcgcca gcagtgcccc gtcgcgccac ggcctgacct gcttggcccc
    16801 ctcccgggcg gggcccgcag cgtccggccg gtctgcgggc aggacgacgg gcaccacggc
    16861 cgcgcagatc aggcacgtaa cggcgtcggc cacgaacagc cagcgcagat cccaccgtcc
    16921 cagcccggcc gcgatcagtc ccgcacccag gcccgccacc gccagggcgg cgttgagcag
    16981 gctgtaggcg cgtatgcgtt ccccggggcc cacggcgtcg gcgatcatcg cctggctcgg
    17041 cggctcgtac agctcgaaga cgagcccgag tagcaccgcg aagcaggcgg ccgccgccag
    17101 actgtcggcg gcggcgatcc ccaactgcgc cagggcgcag ccggacagac ccacgaccat
    17161 cgtgcggcgc cgccccaggg tgtccgcgag gcgcccgccg gccaggcgcg atgggatcgt
    17221 cgcgagtccg aacgcggcgg cgacaagacc ggcggtggcg gcgctcgcgc cgaaccgcgt
    17281 ggtgatcagc accgcgagga agggcagcga gaacgccccg aggcggttga ctgcccgtgc
    17341 cacgatgagc agccatacgg cgcgtggcag ccgtggtccg gtcggtgaga atcgcatgcc
    17401 agcccccgtt gtcaccgacg aatttagtat ggtcagtgat gaaagctagc ttgtgaggag
    17461 tgaccggtca agtgttgttc gatagtcacg tggtgactct gctggaggtg acggtctcgc
    17521 ttgtgaacac gttgaccgac ggcaggcagc ggggcaggcc gtacacggcg ccgcgcggca
    17581 cggacctccc cggcgccgtc gccgccgccc tgccccccac gagccctggc cccgaggaaa
    17641 tcgaccccga ggaggccgct cacctcgccg gtacggcccg gcagatgaag agcgttttcg
    17701 aagccgtcga cgaggaccgt attgatgacg ctgctgccgt catcaactcc ctgctgcgct
    17761 ccacgggcgc tcgcccgcag ctggaccggg tggccgacga gccctggcag gtccacttcc
    17821 acggcgctga cgattccctc gccgtgggct ggagcgccgg atgtgccacc gcactcgccc
    17881 tcgccaccgg gagcgacctc gcgggtcgtc tcggcgtttg ccgggcgccc gagtgcgacc
    17941 gggtctacat cgacaactca cgcaatgccg tacggcagtt ctgctccagc ccctgccaaa
    18001 gccgcgtcaa agccgccacc ttccgcgcac gcaaggccga acagcgctga gtgacagcga
    18061 atccccgcgg ctgttccgcc gcgatcgggc gtgcccccaa cgcggcatcg gcagcgtcct
    18121 cagtgcgcgg tggatgcggg gccggcgagt ttctccctgt cggttgggat gggcggatgt
    18181 gctcgcctga cgtgcccgct ccgcatgccg cggagcgggc tcagttccct gggtgctcag
    18241 cagcagcctg acgaggtgtt gccggagagc atctgctcga cgatcgggcg cccgatctcg
    18301 taggcatcgg cgacgggcac gacctgggcg tcgggatggt gggtgagcca gtccgtggcg
    18361 gcgtcggcgc tggcgaagaa gtggaccttg ttgcagaagg cggcgcggac cgaggtcgga
    18421 gcgtcgggag cgaccaggga gacaaccgcg gtggccggct ccacatcggt gggcccatcg
    18481 ggcgtcacgg tcaggtggac cggttctccg gtgaccgcgc agggggatgc gacctgggcg
    18541 atgtggccga tgacggccgg gaagaccagg gtgtccatgg cgcaccaggc gtagagggtg
    18601 tggctgtcgg tctggtagcg gtgcggtgtg gggttgtgcg taaggccgtc tccgatgatg
    18661 tggccagcgg tgtcgtactc ggtgtcgggc atgtcggcca gcgccgcgcg gatctcctcg
    18721 gtggtgcggt cggcttgggc ggcgagctgg tcgagggtga cgggttcacc ggtggccagc
    18781 agcctgagca gggggcgcag gagccagagt ttgacgccag gggcgcggtt gaccgtgtcg
    18841 gagaagcggg tggcgagctc ttcggtatcg gtgttcacgg tggtacttcc cttccctccg
    18901 ggtggctggg tccgatgccg ccgaccgtag ggtctgcccc cggggtgagg gtcaaggtca
    18961 cgcctcgcag cgcggatctc cggcccagca caggtcgccc tcctccaggt ggtgctggtg
    19021 ctcggtctcg aactcgtcga tccggtcgag gatctgctgc tgagcggtga tgcgctgccg
    19081 caggcgttcg cgggagcggt gcagcagctc ggccagatgc gagccgaccg gtctgtccgg
    19141 gctgtcgaga tacgcggtgg tcaagtcgcg gatctcagcg acggtcaggc ccagtccgcg
    19201 cagttcgccg atgaaccgca cgcaccacag ggcgtcggtg tcgtacaggc ggtagttcgc
    19261 cgggctgcgg ccgagggtgt agatcaatcc gaggtcggtg tactcgcgca gggccttgac
    19321 ggtcacgccg gtctggcggg acaggtcccc gacggtcatc gcgcgcgtac ggcgcccagg
    19381 ccggtgcgtg ttcatgggtg cgtctgttcc ggtcgctcac tgctcagcct gcgcagcagg
    19441 agagcctggc gacatccgcg gtgtaggtct gagcagcgag cttgagggcc tcggccatgg
    19501 tcaggtacgg ggcccaggtg tgggcgagct gatcgacggt catgcccgcg gtgatggcgt
    19561 aggtggcagc ggtgatgatg tcgcccgcgc cgtccgcgat cacgtggacg cccagcacgc
    19621 ggccggtctc ggcgttggct acgagcttga ccagcccacg agtatcgcgg ttggcgagag
    19681 cgcgcggcac gtactcaagc ggcagaacgc ggcagtcgca ggggattccg gcatcggccg
    19741 cctgggcgtc ggtcatcccc accgcggcca tcgccgggct ggtgaaggtg acgcggggca
    19801 gcgcggtgta gtccagcgtg cgctccgcgt cggcgaaggc gttgtcggcg gccagagtgc
    19861 cctgggcggc ggcgacgtag acgaactgcg ggcctccggc gacatccccc gcggcccaga
    19921 tccgctcgtt ggtggtgcgc tggtggtcgt cgacaaccac atcgccgcgc tcgcccgtct
    19981 tgacgccgac cgcgtcgaga ccgaggccgg agatgacggg gcgccggccg gtggcgacca
    20041 gtagcgtttc ggtgcgcagc tcggtctccc tgccgctgcg cgtgcgcacg gcggcgatct
    20101 tggcgccgtc ctcggtgcgg acactggcga gggtggcgcc ggtgtggacg gtgacgccct
    20161 cctcggcgaa gacgtcctca atgacggagg aaacctcagg ctcttcgaac ggggccagct
    20221 gctccagagc ctcgatcaca gtgacctggg taccgaggcg ggcgaagagc tgggcctgct
    20281 ccaggccaac ggcgttgccg cccacgacga tcatcgactc cggcagcgcg tcgagttcca
    20341 tcgccgtggt cgatgtcagg taccccgctt cggccaggcc ctctacgggc ggtgcccagg
    20401 gcgcggagcc ggtggcgaca aggtagtgag cggcttcgat gcgccgggtg ccgccgtcgc
    20461 gcaacgagac ctcgagggcc ggggcgtcgc tggtgccgga gaaggtggcc gttccatgca
    20521 cgatctccca gccgtagtcg gcggcgagtt cggtgtactt ctccgcccgc agctgctcga
    20581 ccagggcatc cttgccgtcg atcaactgcc ggaattcgac gggcagttcc gcggcggcaa
    20641 gcccggggaa tcgcccggcc gctccgcaac cgtggcgggc ctcggctgcg gccagcagcg
    20701 ccttggaggg tatacagccc acgttcacgc aggtgcctcc ggtagtgcca cgctcgatca
    20761 tcgccacgcg cttgccctgg ttggtggcgg cgatagcggc ggcgaaggcc gctgagccgg
    20821 agccgatgac ggccaggtcg aagccggagt gcgttgtggt cacggtgttg cctcctcgtg
    20881 cagagtccag gcctccagac tcactgctat gcgccttgcc ggatagctca ccttcaccat
    20941 actatttggg taagcgaata gattcagccg tggaggccat ccgtatgccg caacgcctca
    21001 gcactcccac cggggtcgcc agcccggctg ctgatgaggt gccgtgcacc catctggaca
    21061 cggtggcgaa attcttccgt gccctggcgg acccgacccg gctgaagctc ctggagttca
    21121 tccttcgagg cgagcgcacc agtgctgagt gcgtcgagca cgccggcatc tcccagcccc
    21181 gcgtctcggt ccacctgtcc tgccttgtgg actgcggcta cgtcaccgcc cgccgggacg
    21241 gcaagaaact gcgctactcc gtcggcgacc cgcgcgtcgc ggacctgctt gtccttgccc
    21301 gctcgctcgc cgcagacaac gccaccgcgc tgacctgttg cacccgcatc cccgacggcc
    21361 cgggataacc ggcaaggcgc accccgtcat ggctgccatc caccggcctc ctcgtcgcaa
    21421 caaggagtct tcccgtgccg gtacggcggc cgccgggatc caatgagccc tgcgcagccg
    21481 ctcgccgagt accggtagga cgaacgcagg cagatcgcct cccatgggag caactccggg
    21541 aattcgaaca ggcctccccg gcaacagcgt tcacgtcccc ggcaccgcgg gtgatcgcga
    21601 cagggattca gcccgggtca gtcccggtcg gccctttccc cgtcgcgcct cagaaggttc
    21661 tgcagggtga agcccggctg cctgcctcgg gctggaccgg ttcggccaac acccgaccca
    21721 gggcccgcac ctgggatttc tcgtccacgc agcggaccac tgccttctcg ggcgggtggt
    21781 ggtagagccc gacgacatca acgaccttct ccacgaactg cgggtccgtg gaaagtttga
    21841 acggtcctgg atattcggct tcagctcgaa cttctgccag gtccgtccga tcgtcgacct
    21901 cgacagaccg gcgcaagggc catcgaggcc cgagagcagt gcgtggcgtt gggcggagat
    21961 gtctccagcg tcgcaacgac gaccgcctca acccggtcgt tgaggaccgg cagtggccgt
    22021 cccggccgca gtccgtcagt cggcccttcc agccatgact ccacgaaccg gcgccgccaa
    22081 cgggtcaccg tggaaacgga cgttcccagc cgggcggcga cgtgcctatt cgacgtcccc
    22141 tccgcgcacg ccagcatgat cccgcaaggc cagggcctgc gaggtcttcg cccgacgtgc
    22201 ccaacacgtc agttgctcgc gctcgactcc ggtcaggacc acccccggac ttcggacgcc
    22261 ccggccggcc ggcatcaacc agccctccat cgagatagcg gaataccccc caggggtata
    22321 tggttgtgat cgtcgtcctg aacggggcaa cgccagcaga cgcatcacac ctatggagct
    22381 gtcatgcaga atcactccgg ccacgaccag accaaccaca gcggccacgg cggagcccag
    22441 cccggcgggc
//
