LOCUS       NZ_CP030864            25131 bp    DNA     circular CON 04-MAY-2024
DEFINITION  Streptomyces globosus strain LZH-48 plasmid unnamed2, complete
            sequence.
ACCESSION   NZ_CP030864
VERSION     NZ_CP030864.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globosus
  ORGANISM  Streptomyces globosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 561689)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Draft genome Sequence of streptomyces globosus LZH-48
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 561689)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Institute of Biophysics, Dezhou University,
            566 DaXuexi RD, Dezhou, Shandong 253023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Portal v. version 2.2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003325375.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:22:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,671
            CDSs (total)                      :: 6,576
            Genes (coding)                    :: 6,458
            CDSs (with protein)               :: 6,458
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 41 of 118
            Pseudo Genes (incomplete)         :: 101 of 118
            Pseudo Genes (internal stop)      :: 11 of 118
            Pseudo Genes (multiple problems)  :: 32 of 118
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:39:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 326106
            Orig. end                         :: 351237
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030864.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25131
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25131
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25131
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15131](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15131)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(696..1850)
                     /gene="cas7e"
                     /locus_tag="C0216_RS32280"
                     /old_locus_tag="C0216_32255"
     CDS             complement(696..1850)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="cas7e"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019981108.1"
                     /locus_tag="C0216_RS32280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32255"
                     /product="type I-E CRISPR-associated protein
                     Cas7/Cse4/CasC"
                     /protein_id="WP_114059323.1"
                     /transl_table=11
                     /translation="MNQRLYVDVHIIQTVPPANLNRDDQGNPKEAVYGGVRRSRVSSQA
                     WKRATRRHFDEHTPEPGRATRTRRITGELTTRIAAGAGLDRPAAERIAAALLVQLGISQ
                     GKKAGDTAYLLFYGNAQLDAVAALVTGNAADLAALDDKLLAEALKELPVADAFATGHPV
                     GVALFGRMVADIPKLNVDAAVQVAHALSTHETQLEFDYFTAVDDQNERDETGAGMIGTI
                     GFNSATLYRYATVGFPQLTANLGGDTEAALDALDRFVDSFARSAPTGYENSFAHRTRPS
                     LVAVVARTDQPVNLVSAFEEPVASAAGIQAASARRLAKEHLQATGVWGDTPLYNGASHT
                     FPTDEPHTKDTAEALAQAFGDPVTFADLRTTLRTRIRSALGDQA"
     gene            complement(1979..2566)
                     /gene="casB"
                     /gene_synonym="cse2"
                     /locus_tag="C0216_RS32285"
                     /old_locus_tag="C0216_32260"
     CDS             complement(1979..2566)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="casB"
                     /gene_synonym="cse2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007830654.1"
                     /locus_tag="C0216_RS32285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32260"
                     /product="type I-E CRISPR-associated protein Cse2/CasB"
                     /protein_id="WP_114059324.1"
                     /transl_table=11
                     /translation="MTEEEHSTQRIWHRYIGADGKWRHTSGTAAQRRPPGEDLAVLRKG
                     LSRPAGTVLEMFRFYTCEVDDFAARRGEVSAAQEAEHIALALYGLHQQSQDQPMHRDGV
                     SLGRAMRALRLHDRTSEDAVDARFQQTFSATSTAALQLRLRGLVTQLRDIKQPLDYTLL
                     AADVLRWNRPDSRNRVRRRWGLDYHARPQKTP"
     gene            complement(2750..4456)
                     /gene="casA"
                     /gene_synonym="cse1"
                     /locus_tag="C0216_RS32290"
                     /old_locus_tag="C0216_32265"
     CDS             complement(2750..4456)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="casA"
                     /gene_synonym="cse1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007830655.1"
                     /locus_tag="C0216_RS32290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32265"
                     /product="type I-E CRISPR-associated protein Cse1/CasA"
                     /protein_id="WP_114059495.1"
                     /transl_table=11
                     /translation="MTHAFFLTDDPWLLLPSATGGPAQRRSLRTALVEAHEFGDLVVEI
                     PTQKAAVLRQVMLAVVVAALGRPADEREWAAWHAAGRWSPQQRQTLEDYLDAHRDLFDL
                     FDPVRPFGQVGGLSTAKGETKNAALIVATSATGNNVPLFASRTEGDSYSLTPAQAAHWL
                     LHAHCWDTAAIKTGAVGDPQAKAGKTTGNPTGPLGQLGVTLLAGRTLFETLLLNIPVGA
                     PPTSTDLPQWKRRDPSAPRSVGSPQWQTRAPEGLLDLWTWQSRRIRLFPEDTDEGLRVT
                     RVLVAAGDRMTHTPETEPHTMWRLEPIGSRTSGKAKSGAALPRRPLRLQPGKAAWRGLD
                     ALLAAERESREAGEKTSGFATSKILDQAGGLVSELGEGYPLRVELCGIAYGNQSAVIDD
                     VMFDALPLPLAALDADSDVRAALLEVAAQAEELATAVNHLTADLRRALGSDPIPWDKGQ
                     RPGEFVLHALDPLVRRLLTGMRGVEDLERIEAGQLAWEQLAWSRTEDIVDRLLQAVPVG
                     AFAGRTTSQGEGKPEHTHRASSAEASFRRRRAEILHRADAHRRNSAALGST"
     misc_feature    complement(4412..4414)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4739..7513)
                     /gene="cas3"
                     /locus_tag="C0216_RS32295"
                     /old_locus_tag="C0216_32270"
     CDS             complement(4739..7513)
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="cas3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192861.1"
                     /locus_tag="C0216_RS32295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32270"
                     /product="CRISPR-associated helicase Cas3'"
                     /protein_id="WP_246043012.1"
                     /transl_table=11
                     /translation="MAHLLDTAAVAELLWEDFLAPSTRSALNEVAGGPDRGRRLFAWLC
                     GVHDCGKATPVHQRLWPEGAEAVRQSGLTWVESAAVAGVKNKRRWRHDWAGGLVARELL
                     TAAGWGPEQVDWTWPLVAGHHGAFPSLKDVQEPGSAKGQLRGRGVWRRVQEAVVDAFTG
                     ELGFGGLGEVEPVAVPSRALQLQLSGLVVMADWIASDERHFQGIDDLERVSLGESRGRA
                     AKAWAALGLQHGWGALALPGPEAFLDRFGYTPRPSQAMVVEAARRIGGPGLMVIEAPMG
                     EGKTEAAHAAAEVLAARFGADGVFVGMPTQATSDPMFTRTRRWLGAVDPELASRVVLLH
                     GKRAFNSEWKELLENAGASADEAFRGVDEYGMDDDPYGVGHAECGEQERHAPAEWFLGP
                     KRGLLAPFVVGTVDQLLYAATRTRHVMLRMAGLAGKVVVLDEVHACDVYMGQFLGEALR
                     WLGQAGVPVVALSATLAPAQRQALFEAYLAGAASRAELEVCVPAPAGYPSVTAAWLDDA
                     RQPQFHTDSTDSWRADLPVAVGVLPERLPGAGSSREDRLRLQAEADAAVADLLAEELAG
                     GGTALVIRNSVGRAQSLYEELRGRFGEAEVRLLHARFTVARRADLTEECLRLLGPRAPR
                     PRGGRLILVATQLAEQSFDVDADLLVTDLAPVDLLLQRMGRLHRHEGTWRPERLRAPKA
                     FVTGFEPRPGREPVFGYGSEMIYGRHLLLRTAAVLPVPGGDWSFPGDVPRLVESVYGSD
                     AALVPEAWRETGEAARQAQEQADRGRAAVARGFLLTGPGDHERRTLAGLHYAGSGGSDE
                     DALRAAVRDGDESVEVVLVVRQEGDEVYRTLAGRALSVNGDVAAEVLDEVVGSTVRLPP
                     SLTQPALGLKPLPGWHGHPWLRRARALVLDGSGRARVGDFTVSYDAEFGLRQL"
     repeat_region   7981..9798
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=334289..334313
                     /rpt_unit_seq="ggagcatccccgcgcccgcggggtc"
     misc_feature    8892..8909
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.07"
                     /tool="antismash"
     misc_feature    9200..9214
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     misc_feature    complement(9829..9840)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.41"
                     /tool="antismash"
     misc_feature    complement(9852..9866)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.56"
                     /tool="antismash"
     gene            complement(10001..10966)
                     /locus_tag="C0216_RS32300"
                     /old_locus_tag="C0216_32275"
     CDS             complement(10001..10966)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009315830.1"
                     /locus_tag="C0216_RS32300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32275"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_114059325.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.4e-41, bitscore:
                     135.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTPPEAAVLAALTGQPLSQVAARHACSVPLLADAVDLYRAAGRA
                     ALSANDGAERWQQVNVEFSDYGRAREAFSAYLLPALRQAYNEGLIASWWFVRKHPCWRL
                     RVLPAPATSSRAVRARLTANLDAAIACGAVQQWRVIPYEPETAAFGGAVGIQLAHDLFH
                     TDSEGALAFLHTADANPSRQPDAKVTSLLVVTLLLRAAGQEWSEQGDVWARVEASRPLP
                     AGIPGEQVSSMTPSIHRLLTINTAGLTADDELLMPVAAWAAGLEKAGRCLADAHDHGRL
                     TLGLRSILSRHIIFHWNRMGFTTRQQAIWARAARATILGE"
     gene            complement(10978..12105)
                     /locus_tag="C0216_RS32305"
                     /old_locus_tag="C0216_32280"
     CDS             complement(10978..12105)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319710.1"
                     /locus_tag="C0216_RS32305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32280"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_114059326.1"
                     /sec_met_domain="LANC_like (E-value: 6.3e-40, bitscore:
                     131.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATPHAADLATGQSLAHGSLGTVLLDVERAHRGTTAWHEVQRRL
                     TGIGPLIDGDQAGLFLGAPAMAFVLHLAAADTGRYANALAALDRTIAAHTRQRLAAAHT
                     RIDHGIPAAFAEYDLLRGLTGIGALLLRRAPTGDDLRGVLEYLVRLTRPLPDGQPGWWV
                     WHGPTNLHQPTPAGHANAGLAHGITGPLALLALATLRGITVPGQETSMQTICHWLDQIR
                     QTDRHGTHWPRWTHTAGPATHHTEAPSWCYGTPGIVRAQQLAALALDDSARQRAVEEAL
                     LSCIGDSAQLDQLTGRSLCHGIGGLLRVVQRVAADALDPHRFQEHVPRLTQRFLAAPPP
                     QGSGFLEGTAGAALAFQSADTPAPACDWDTSLLLV"
     gene            complement(12102..15131)
                     /locus_tag="C0216_RS32310"
                     /old_locus_tag="C0216_32285"
     CDS             complement(12102..15131)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483568.1"
                     /locus_tag="C0216_RS32310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32285"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_246043013.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.5e-184,
                     bitscore: 607.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.1e-17,
                     bitscore: 56.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.9e-29, bitscore:
                     95.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMYEALDAALLRATARPLTDALPPWPDLAQDDVPAWTAWITEVW
                     SDEAASAAVEVASPLLADAVRGVISGKVARPRPVRRAVVSLMRYLLRSRYRATPFGLFA
                     GPAPIRTGASGHARWGAHHRIDVRADAEWLAAAIASLENIPGILQLLPVVADPTHVIRG
                     AKVTVPHQPGKEGPVEKTMRRTKAIETILALAASPITVAEIIDKLHGDYPTTPVEIVEN
                     TVRGLISHRILLTSLRAPMTCDDPLDHLVQQLDLLRADRIPAAAAIVAELRRIRRLLRR
                     HLASPPAAQRDIRDEATRRMTAVTGVATRTLVVTSRPDCDVRLPAAVAREAQTALAAIA
                     RISPYPAGPPAWQDYRTRFLERYSMGALVPVRDLTDPNIGLGFPAGYRGSVLKRPVLAT
                     TRRDEHLLALAQDAAQTNRREIALTREDLDALTVGSLWQVPAHVELCFSVHAPSLHALN
                     DGRFELSIVGLSLAAGTTTGRFLPLLEPDDRERMQRVYTDLPTLTEAADRAQVSSPPLR
                     LRTQNVSRSPAVVPHLLSLGEHNPVANLDLDDLGVGADSRRLYLASLSTGRIIEPSVMN
                     AVEPTNATHPLVRFVTEVHRSHTAVLAPFAWGAASSLPFLPEVRIGRTILSPACWRLRH
                     HELARDGAERWPHRFEHWRAVYGVPRTVFLGTDDQRLRLDLADLAHQQLLRLELERTRR
                     VTVHEAPPEAAYGWLGRAHEVTMPFVATQRPVRRPTPTTVVPRGEGRLPGASPWTFLKL
                     YSHPARATELLTAALPTLMDTWDPQPAWWFTRYSDPDPHLRIRIQLPGAAAFGDVAQAV
                     GAWAAQLRLDGLLRRVQWDTDEPETGRYGTGRLLAAAEQVFIADSAAARAQMKLRIPAE
                     LAPAVTAASFHDIATVLAGSTDAARVWLLSVLPQAEGAAPPRAVQTSALYLAAPDRSGL
                     LEVPGGSVLIDAWARRRAALESYRDDLSAAGRDPLDVLPSLLHMHHNRAAGLDPEGEAD
                     CRRLARTIAVQSTARAEGAR"
     aSDomain        complement(14412..14675)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C0216_RS32310_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.10E-18"
                     /identifier="RREFam001.1"
                     /label="C0216_RS32310"
                     /locus_tag="C0216_RS32310"
                     /protein_end="240"
                     /protein_start="152"
                     /score="56.9"
                     /tool="antismash"
                     /translation="VVADPTHVIRGAKVTVPHQPGKEGPVEKTMRRTKAIETILALAAS
                     PITVAEIIDKLHGDYPTTPVEIVENTVRGLISHRILLTSLRAP"
     misc_feature    complement(15131..15147)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.18"
                     /tool="antismash"
     gene            complement(15217..15408)
                     /locus_tag="C0216_RS32315"
                     /old_locus_tag="C0216_32290"
     CDS             complement(15217..15408)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018724312.1"
                     /locus_tag="C0216_RS32315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32290"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_114059328.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.6e-15, bitscore:
                     51.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARQNNPVLKAATDYASGTDSDFNLDIETLASAPVVAGLLNDTGD
                     GCGSTCQSACSNSTCISG"
     CDS_motif       complement(15304..15408)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MARQNNPVLKAATDYASGTDSDFNLDIETLASAPV"
                     /locus_tag="C0216_RS32315_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15217..15303)
                     /prepeptide="core"
                     /locus_tag="C0216_RS32315_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-7.70"
                     /molecular_weight="2477.7"
                     /monoisotopic_mass="2476.1"
                     /core_sequence="VAGLLNDTGDGCGSTCQSACSNSTCISG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MARQNNPVLKAATDYASGTDSDFNLDIETLASAPV"
                     /leader_location="[15303:15408](-)"
                     /alternative_weights="2495.7"
                     /alternative_weights="2513.7"
                     /alternative_weights="2531.7"
                     /alternative_weights="2549.7"
     misc_feature    complement(15373..15382)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(15467..16699)
                     /gene="fxlM"
                     /locus_tag="C0216_RS32320"
                     /old_locus_tag="C0216_32295"
     CDS             complement(15467..16699)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009329291.1"
                     /locus_tag="C0216_RS32320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32295"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_246043014.1"
                     /sec_met_domain="PCMT (E-value: 2.4e-38, bitscore: 126.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTDMKPPASDRELRDQMVSRLIEMGALRSSGAVAAFRKVPRHL
                     ATPQTDITKTYGVEDAVITKTDADGIQLSSVSAPRIQAMQIEQADLHPGQRVLEIGSGG
                     VNAAYLAEIVGPGGTVVSMDIDRDVTARAERFLKETGYDRRVKLVTADGEDGAAADGPY
                     DRIIVTVQAADIPPTWIDQLVDGGRLVVPLRMRGMTRTIAFVRDGERLVSDGFELCGFV
                     PMQGAGENRVRLLLLHDVPGEEVGLRLDGHPEPNQGALREALHMPSVEAWSGVTLAGDE
                     SNEHLDLFLTTVLENLPLLTGTAAARSRGLIASASPLGVPTLVRGGSFAYRTVRRTQDP
                     DRFELGAIGHGPEGAELAEALVVQMQSWDRDFRDDRARIDVYPAGTPDEKLPEGGRVID
                     RPHTRVIISWP"
     misc_feature    complement(16734..16748)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.56"
                     /tool="antismash"
     gene            complement(16955..17425)
                     /locus_tag="C0216_RS32325"
                     /old_locus_tag="C0216_32300"
     CDS             complement(16955..17425)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS32325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_32300"
                     /product="hypothetical protein"
                     /protein_id="WP_114059330.1"
                     /transl_table=11
                     /translation="MDLTEIPAVRDGMGRDNALQRQWSPLASRPIRQAAPLTRLWGFRT
                     DGVRAAASLARRNSLMLKVVRYVQAPEREAGAQFEELELVARSRHYPVVDELCLDVGGP
                     MLLEYRSGLRAARRLLGLRRVGRLGVAVSWSLDVGCPGKTLRAELPLPLTEL"
     gene            17723..18967
                     /locus_tag="C0216_RS32330"
                     /old_locus_tag="C0216_32305"
     CDS             17723..18967
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337831.1"
                     /locus_tag="C0216_RS32330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32305"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_246043015.1"
                     /transl_table=11
                     /translation="MAEKRLGSRELADLVNAAVGEITGRVGGLDDSNIRAWRSGRVRCP
                     KGAQLRALELLSGLSAADLGFVRRARLPAPDPNQEPPVERRTFLAFPAAAAAAGVPSPA
                     SAASTARVGMSDVARLHQRFTDIIASDHRHGGQASIEHEAVRLASEALLLQKSGTASQR
                     VRTNLYATAASFMSSAMWAAIDGRRFGDARNHLRHAAQLAELSGDPAIKFRIWSHAGTM
                     YRHQGSPAEAAAANNVARGLSLARRDPLFASLGLARHAAIHAAAGERRAVRRAFGHAQE
                     AMARANRGDVRPVWLTAFFDQAELDSLALSAYLTLGDWAMAEAHGHRCLAALRPHMRRS
                     KAITTSRLALAQLEQGDAESALATAMRVPADAASRHPRVVGMLDTFGRRLNAIAPQSAH
                     EAAWREFITRKDHTA"
     misc_feature    17754..17769
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.03"
                     /tool="antismash"
     misc_feature    17912..17914
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18964..19509
                     /locus_tag="C0216_RS32335"
                     /old_locus_tag="C0216_32310"
     CDS             18964..19509
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008739492.1"
                     /locus_tag="C0216_RS32335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32310"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_114059332.1"
                     /transl_table=11
                     /translation="MTTSAPAIRRHATLTPALKAVIGDLYALVRADLLDHPNYRLDVFL
                     ERLDRHAAEPGWAVVIAHGSDAAPVGYAYANSVGPGDRWWKRLNSPAPVRYTGKDAVAV
                     KEIGVIPAWRGIGVSRHMHDALLADRGEPHATLMVNPVAGDGKVMRLYEGWGYEEIGVV
                     QPSPDSPWLVCMGRPLRA"
     misc_feature    complement(19784..19799)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            19875..20075
                     /locus_tag="C0216_RS32340"
                     /old_locus_tag="C0216_32315"
     CDS             19875..20075
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS32340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_32315"
                     /product="hypothetical protein"
                     /protein_id="WP_114059333.1"
                     /transl_table=11
                     /translation="MLRHTTVWSWWTLLWGPLPLLGAATAVHEWRLSARKRWRIGVMEW
                     LALVWANFGFAVCLAGVWVLG"
     gene            complement(20083..20829)
                     /locus_tag="C0216_RS32345"
                     /old_locus_tag="C0216_32320"
     CDS             complement(20083..20829)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891815.1"
                     /locus_tag="C0216_RS32345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32320"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_114059334.1"
                     /transl_table=11
                     /translation="MPGGRLTQQERQQIARGLADGLAYAEIARRLDRPTSTVTREVMRN
                     GGHTAYRADLAHRATEQRAQRRRKPAPRNAPTPPQPHGRDSEEVRRYEEEFTTVLVGSG
                     VPKMMARVMVCLYTTDAGSLTAAELVQRLQVSPASVSKAIAFLEEQGLVRRERDERRRE
                     RYIVDNDVWYQSMLASARSTAQLVVVARQGVGILGPDTPAAARLENIARFVDFVTESIV
                     RAAEQAREILYAKPPAAEADDAAARP"
     misc_feature    complement(20989..21001)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     misc_feature    21010..21024
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            21071..21739
                     /locus_tag="C0216_RS32350"
                     /old_locus_tag="C0216_32325"
     CDS             21071..21739
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029635.1"
                     /locus_tag="C0216_RS32350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32325"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_114059335.1"
                     /transl_table=11
                     /translation="MQTFATPAPVSVVLDVPAGSIRFIAADRADTTVEVLPADASKERD
                     VTAAQETTVACTDGVLTITTPKKKGLLAGAGCVEVTVRLPADSHVEARTASAEFRGVGR
                     LGEVAYDSAHGTVKLDEVAAARLTLQAGDITVGLLGGPAELRTQKGDLTVTEARRGPLT
                     LRTEHGDITVGAARGTSASLDAGTSYGRIHNALANADGDAPALPIHATTAYGNITARTL
                     "
     gene            complement(21827..22447)
                     /locus_tag="C0216_RS32355"
                     /old_locus_tag="C0216_32330"
     CDS             complement(21827..22447)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510661.1"
                     /locus_tag="C0216_RS32355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_32330"
                     /product="HAD family phosphatase"
                     /protein_id="WP_114059336.1"
                     /sec_met_domain="HAD_2 (E-value: 1.9e-12, bitscore: 42.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTCVILDIGGVLEFTPETGWVQRWEEKLRLPPGTVDERMGGVW
                     QAGSVGAISERDVHEQAATRLGLDAADAEAFMADLWAEYLGTPNEELIAYVDGLRGRCR
                     LGILSNSFVGARERETARYGFDRLVERIVYSHEIGVGKPDARAFGTACAQLGVRPEDCL
                     FVDDVAVNVEAARAAGMQGHLFVDNAATIARITAHVERGRAGA"
     misc_feature    complement(23127..23143)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.18"
                     /tool="antismash"
     gene            23427..23669
                     /locus_tag="C0216_RS33740"
     CDS             23427..23669
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS33740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162793378.1"
                     /transl_table=11
                     /translation="MTLRHPYEDRKLTFTRHAHAYRIIDTFLLASLLSQLVEAGEAHRL
                     GDPEWLSRVVGRLTPLSPWLTRNRLTQAVEQAWQV"
ORIGIN
        1 ggtgcggcgg gtggtgtagg tgcggttttg gggggcgaag gagaggggga cgtcgtcgcg
       61 gacgtcgtct ccggcggggt cgtcgagggt ggcgggcagg tcgatgcggg ctgcgttgcc
      121 gttggtgcgg ccccagcgtg tgcggacggc ctcggtggct tgccagggct cttcgcggag
      181 tgcgtcttcg agtggggcga tgcgccgacc gaggaggagg ggttgtgcgg gcgggcagga
      241 gcggcggccc agggcgaggg ggaaggcggg gtggcggacg gcgtgggcga gggtgtcgat
      301 gaggccttcg gggccttcga cggcggcgag gaagacggcg tcctggaggt agaagcgctg
      361 ggtgatgtgg gtgtgtttgg cgggtgaggt gggtttctgc cggcccttgg cgctgacggc
      421 ggcggagagc aggggctggc cgcggtagtc gccgacggtg tggtagtcgc gcaggatgct
      481 gccgggctgg tcgatgcgga tgccgagggc gagtccggcg aggtcgtcca ggggtgcgtg
      541 gcgggggcgg ccggcggctg cggcaagcag gccgacgatg ccggacttgg tgggttcggg
      601 ccgtgtttcg cgccggttga aggcgctgcg gtcgccccat gactgcagcg gcccggcgag
      661 gcgcagcagt aggacggagc gggggccggg ggcggtcacg cctggtctcc cagggcgctg
      721 cggatgcggg tgcgcagggt ggtgcgcagg tcggcgaagg tgacggggtc gccgaaggcc
      781 tgggcgaggg cctcggcggt gtccttggtg tggggctcgt cggtggggaa ggtgtggctg
      841 gcgccgttgt agaggggggt gtcgccccag acgccggtgg cctggaggtg ttccttggcc
      901 aggcggcggg cggaggcggc ctggatgccg gctgcggatg cgacgggttc ttcgaaggcg
      961 gagacgaggt tgaccggctg gtcggtgcgg gcaacgaccg cgacgaggct ggggcgggtg
     1021 cggtgggcga aggagttctc gtagccggtc ggtgcggagc gggcgaagct gtcgacgaac
     1081 cggtcgaggg cgtcgagggc agcttcggtg tcgccgccga ggttggcggt gagctggggg
     1141 aagccgacgg tggcgtagcg gtagagggtg gcggagttga agccgatggt gccgatcatt
     1201 ccggcgccgg tctcgtcccg ctcgttttgg tcgtcgacgg cggtgaagta gtcgaattcc
     1261 agctgtgttt catgggtgga cagggcgtgg gcgacctgga cggcagcgtc gacgttgagc
     1321 ttgggaatgt cggcgaccat gcggccgaag agggccacgc cgacggggtg gccggtggcg
     1381 aaggcgtcgg ccacgggcag ttccttcagc gcttcagcca ggagcttgtc gtcgagggcg
     1441 gcgaggtcgg cggcgttgcc ggtgaccagg gcggcgacgg cgtcgagctg ggcgttgccg
     1501 taaaagagga gataggcggt gtctcccgcc ttcttgccct ggctgatgcc gagctggacc
     1561 aggagggccg cggcgatccg ttcggcagcg ggacggtcga ggccggcgcc ggcggcgatg
     1621 cgggtggtga gttcgccggt gatgcgcctg gtgcgggtgg cgcgcccggg ctcgggggtg
     1681 tgctcgtcga agtggcggcg ggtggcccgc ttccaggcct gggaggagac acgggagcgg
     1741 cgcacgccgc cgtagacggc ttccttgggg ttgccctggt cgtcgcggtt caagttggcc
     1801 ggcgggacgg tctggatgat gtgtacgtcg acgtaaaggc gctggttcat cggatggctc
     1861 caagatcgtg tgaaggcggc agtacgcgcg gacggcgcgc ctgcgggcag atggagggcc
     1921 cgccgcgagg gcagccggcg ggcagggtgg ggaggagcag gcgtcagccg acagggccct
     1981 acggggtttt ctggggccgg gcgtggtagt ccaggcccca gcggcggcgt acgcggttgc
     2041 gggagtcggg ccggttccat cggaggacgt cggcagccag gagggtgtag tcgaggggct
     2101 gcttgatgtc cctcagctgg gtgaccagac cgcgcaggcg cagctggagc gctgccgtcg
     2161 atgtcgcgga gaaggtctgc tggaagcgtg cgtcgaccgc gtcctcgctg gtgcggtcgt
     2221 gcaggcgcag ggcgcgcatg gcgcggccga ggctgactcc gtcgcggtgc atcggctggt
     2281 cctggctctg ctggtgcagc ccgtagaggg cgagcgcgat gtgctcggcc tcctgggcgg
     2341 cggagacttc gccgcggcgc gcggcgaagt cgtcgacttc gcaggtgtag aagcggaaca
     2401 tctcgagcac ggtgccggcg ggacgggaca ggcccttgcg caggacggcg aggtcctcgc
     2461 cgggcgggcg ccgctgagcg gcggtcccgg acgtgtgcct ccacttgccg tcggcgccga
     2521 tgtagcggtg ccagatcctc tgcgtggagt gctcttcttc ggtcatgacc gtatccagac
     2581 gtgatgagac tgcggtgccg tgaaggaggg cgcgggcatg cgcaaggggg agtgccctgg
     2641 ggtatgccgg gagtcctgcg gccggagggc ggtgcgggaa cgggccgcgc ggggcctgcg
     2701 gcctcagggc cgcgaggccg tcgaagggcc gtggccgcgg cggtgccgtc taagtgctgc
     2761 cgagggcggc gctgttgcgt cggtgggcgt cggcgcggtg gaggatctcc gctcggcgcc
     2821 tgcggaagga cgcctcggcg gacgaggcgc ggtgggtgtg ctccggcttg ccttcgcctt
     2881 gggaggtggt tctgccggcg aaggccccga ccggcacggc ctgcagcagg cggtcgacga
     2941 tgtcctcggt tcgggaccag gccagctgct cccaggcgag ctggccggcc tcgatgcgtt
     3001 cgaggtcctc tacgcccctc atccccgtga gcaggcgccg caccagcggg tccagcgcgt
     3061 gcaggacgaa ttcgccgggg cgctggccct tgtcccaggg gatcgggtcg ctaccgaggg
     3121 cgcgcctgag gtcggcggtc aggtggttga cggccgtggc cagctcttcg gcctgggcgg
     3181 ccacttcgag gagggcggcg cggacgtcgc tgtcggcgtc cagtgcggcc agcggcaggg
     3241 gcagggcgtc gaacatgacg tcgtcgatga cggccgactg gttgccgtag gcgatgccgc
     3301 acagttccac ccgcagcgga tacccttcgc cgagttcgct gacgaggccg ccggcctggt
     3361 cgaggatctt gctggtggcg aatccgctgg ttttctcccc tgcctcccgg gactcgcgtt
     3421 cggctgccag gagtgcgtcg agtcccctcc aggcggcctt ccccggctgg aggcgcagcg
     3481 ggcggcgcgg cagggcagcg ccggacttgg ccttgccgga ggtgcggctt ccgatcggtt
     3541 cgaggcgcca catggtgtgc ggctcggtct cgggggtgtg ggtcatccgg tccccggcgg
     3601 cgaccaggac ccgggtcacc cgcaggcctt cgtcggtgtc ttcggggaag agccggatcc
     3661 tgcgggactg ccaggtccac aggtccagaa gcccttcggg ggcacgggtc tgccactgcg
     3721 ggctgccgac cgagcggggg gctgacgggt cgcgcctctt ccactgcggc aggtcggtcg
     3781 aggtcggcgg ggcgccgacc gggatgttca gtagcagcgt ctcgaacagg gtccggccgg
     3841 cgagcagcgt cacgcccagc tgccccagcg ggccggtcgg gttgcccgtg gtcttgcccg
     3901 ccttcgcctg cgggtcgccg accgcgccgg tcttaatggc tgcggtgtcc cagcagtggg
     3961 cgtgcagcag ccagtgcgct gcctgcgccg gcgtcagcga gtaggagtcg ccctccgtgc
     4021 gcgaggcgaa caggggcacg ttgttgccgg tggccgaggt ggcgacgatc agagctgcgt
     4081 tcttcgtctc gcccttcgca gtggacagcc cgcccacctg accgaagggc cgcaccggat
     4141 cgaacaggtc gaacagatcc cggtgcgcat cgaggtagtc ctcgagcgtc tggcgctgct
     4201 gcggcgacca ccggccggcg gcgtgccagg ccgcccactc ccgctcgtcg gccgggcggc
     4261 cgagcgcggc gacgaccacc gcaagcatca cctgccgcag gacggcggcc ttctgggtgg
     4321 ggatctccac caccaggtcg ccgaactcgt gcgcctcgac aagcgccgtc cgcagggagc
     4381 gccgctgtgc cggaccaccg gtggccgagg gtaagagcag ccacggatca tcggtcagga
     4441 agaaggcatg agtcatcagc accccttgaa ggaatctctt atgtttaacg ctagcagcgg
     4501 ggttgaggcg cacaggtgct ttctctacaa ccaggtgcga caatccggga gttgaccccg
     4561 cccggctcgc accacgcggt ccacgcaggc ggggatggtc ccctcttgtg tttgcgtcac
     4621 agcccggggc tcacctcgtc cccgccacgc ggggtaccga gccgccgggc cccgcccggc
     4681 ggctcaccac acccgcccat ccccgccgca gagcccacag aaccggccct gcgcccccct
     4741 acagctgccg caagccgaac tccgcgtcat aggacaccgt gaagtcaccg acacgggccc
     4801 tgcccgagcc gtccagcacc agggcgcggg cgcgccgcag ccacggatgc ccgtgccaac
     4861 ccggcagcgg cttcagcccc agagccggct gcgtcaggga gggaggcagc ctgaccgtcg
     4921 agcccaccac ctcgtccagg acctcggccg ccacgtcccc gttgacgctc aaagcccgtc
     4981 ccgccagggt ccggtacacc tcatcgccct cctggcgcac cacgagaacg acctccacgg
     5041 actcgtctcc gtcacgcacc gccgcccgca gcgcatcctc gtcgctgccg ccggatcccg
     5101 cgtagtgcag gcccgcgagg gtccggcgct cgtgatcacc cgggcccgtc agcaggaagc
     5161 cgcgggcaac tgcggcgcgg ccacggtccg cctgctcctg cgcctggcgg gcagcctccc
     5221 ctgtctcccg ccacgcttcg ggaacaaggg cagcatccga cccgtacacg ctctccacca
     5281 gccgggggac gtctcccgga aacgaccagt ccccgcccgg cacaggcagg acggcagcgg
     5341 tccgcagcag cagatggcgc ccgtagatca tttcgctgcc gtagccgaac accggctcgc
     5401 ggcccgggcg cggctcgaag ccggtgacga acgccttcgg cgcgcgcagc cgttccggac
     5461 gccaggtgcc ctcgtgccgg tgcagccgtc ccatgcgctg cagcaggagg tcgacggggg
     5521 caaggtcggt gaccagcagg tcggcatcga catcgaagga ctgctcggcc agctgggtcg
     5581 ccaccaggat cagcctcccg ccccgcggcc tcggcgcccg cggccccagc agacgcaggc
     5641 actcctccgt gaggtccgcg cgccgtgcca ccgtgaagcg ggcgtgcagc agccgcacct
     5701 cggcctcacc gaagcggccg cgcagctcct catagagact ctgcgcccgt cccaccgaat
     5761 tccggatgac cagcgcggtc cccccgccgg ccagctcctc cgccagcagg tcggctacag
     5821 cggcgtccgc ctctgcctgc agccgcagcc tgtcctcacg cgaggaaccc gcaccgggca
     5881 gtcgctccgg cagcacgccg accgccaccg ggaggtccgc ccgccagctg tccgtcgaat
     5941 cggtatggaa ctgcggctgc cgggcatcgt ccagccacgc agctgtcaca ctcggatagc
     6001 ccgccggggc gggaacgcac acctcaagct ccgcccgcga cgcagccccc gccaggtatg
     6061 cctcgaacag agcctgccgc tgtgccggcg ccagcgtcgc cgagagagcc accacaggca
     6121 caccggcctg ccccagccac cgcagcgcct ctcccaggaa ctggcccatg tacacgtcgc
     6181 acgcatggac ctcgtccagc acgacgacct tgcccgcaag ccctgccatc cgcagcatca
     6241 cgtgccgcgt acgcgtcgcc gcatacaaca gctgatcgac tgtacccacg acgaacggcg
     6301 cgagcagccc ccgcttcggc cccagaaacc actccgcggg cgcatgccgc tcctgctcac
     6361 cgcactccgc gtgccccaca ccgtaggggt cgtcgtccat gccgtactcg tcgacgccgc
     6421 ggaacgcctc gtctgcggac gcgcccgcgt tctccaggag ctccttccac tcgctgttga
     6481 acgcccgctt gccgtgcagc agcaccaccc gggaggcgag ctcagggtcg acggccccca
     6541 gccagcgccg cgtgcgcgtg aacatcggat cgcttgtcgc ctgggtcggc atccccacga
     6601 aaacaccgtc cgccccgaac ctcgcggcca ggacttccgc cgccgcgtga gccgcctccg
     6661 tcttcccttc ccccatggga gcctcgatca ccatcagccc cggaccgcct atacggcgcg
     6721 cggcctcgac caccatggcc tgcgagggcc tgggcgtgta gccgaaccgg tccaagaacg
     6781 cctcaggtcc cggcagtgcc aaagcccccc agccgtgctg caagccaagg gcggcccacg
     6841 ccttggctgc ccgtccacgc gactcgccca gactcacccg ctccagatcg tcgatgccct
     6901 ggaagtgacg ctcgtcgctc gcgatccagt cggccatcac caccaaaccg ctcaactgca
     6961 actgcagggc ccgcgacggg accgccaccg gctcgacctc ccccaggccc ccgaagccca
     7021 gctcccccgt gaaggcatcc accacggctt cctgcacccg gcgccagacc cctcggcccc
     7081 tcaattgccc cttcgccgac cccggctcct gcacatcctt caacgacgga aacgcaccgt
     7141 gatgccctgc aaccaacggc cacgtccagt ccacctgctc cgggccccag cccgccgcag
     7201 tcaacagctc acgtgccacc agcccgccgg cccagtcatg acgccagcgc cgcttgttct
     7261 ttacccccgc cacagccgcc gactcgaccc acgtcagccc tgactgccgc accgcttcgg
     7321 caccctcggg ccacagccgc tggtgcaccg gcgtcgcctt cccgcagtca tgaacgccgc
     7381 agagccaggc gaacaaccgc cggccgcggt ccggcccccc ggcaacctcg ttcagcgccg
     7441 accgcgtcga cggggcgaga aagtcctccc acagcaactc cgcaaccgcg gcggtatcca
     7501 gcaggtgcgc catcagcagg ctcgtcgtac cccctgcccg ctcccgcgac ttcccccaca
     7561 acacggccaa agcccccacg acagcaggct cgtaccgccc acccaagcgc cctaagtcca
     7621 ccagacctcc aaccaccgca cgtccagagc caccacaccc tagaaggcca cactgacaac
     7681 gcgagcgacc tgcgaaaacg ccaagcagag caccgatcga tgaaccagac gcacgcatgc
     7741 caatacgtga aatgtccgaa cccacccgca gcgaccccac gagcgctggg cctgcgaaac
     7801 cgagggcgtg ggccgccaca gccctcctcg ggttcgcctc gaccgctggc atgctggcca
     7861 gccaacacgc ggctgtccac gtctttccgg cggcccagtg gacttcgagc acgggcaccc
     7921 ccgcaggcgc gagtaccctc cgaagcccgc ccctgcaaca ccttccggtc ccgatctcac
     7981 cggagcagcc ccgcggtgcg gggtcgagca ggtcgacgac cgttgacgta cagggcctcc
     8041 agcgcaactt gctcagccac ggagcatccc cgcgcccgca gggtcgactg cacgggagcg
     8101 gcggcggggg caccctggcc cggagcatcc ccgcgccagc ggggtcgact tgcccatgtg
     8161 gccggtgaac acctggccga acggagcatc cccgcgcccg cggggtcgac gccgacggcg
     8221 gctcggcgtg acggacggcc ttcggagcat ccccgcgccc gcggggtcga cgcggcgggg
     8281 gtcagtgggt cagcatccgt cgtacggagc atccccgcgc ccgcggggtc gactacgcgt
     8341 ccactgggtc cgtcttacgt gccaccggag catctccgcg cccgcggggt cgacaccgcg
     8401 ggcaccgtca ccgggatcga caccacggga gcatccccgc gcccgcgggg tcgaccggta
     8461 gcgcgcaact gcgcagcggt cgtggcacgg agcatccccg cgcccgcggg gtcgacgtcg
     8521 ggaggggagc ggccgcgagc cgggcctgcg gagcatcccc gcgcccgcgg ggtcgacgcg
     8581 gcgggggtca gtgggtcagc atccgtcgta cggagcatcc ccgcgcccgc ggggtcgact
     8641 acgcgtccac tgggtccgtc ttacgtgcca ccggagcatc tccgcgcccg cggggtcgac
     8701 accgcgggca ccgtcaccgg gatcgacacc acgggagcat ccccgcgccc gcggggtcga
     8761 ccggtagcgc gcaactgcgc agcggtcgtg gcacggagca tccccgcgcc cgcggggtcg
     8821 acgtcgggag gggagcggcc gcgagccggg cctgcggagc atccccgcgc ccgcggggtc
     8881 gacgtggacg ggttcccgga gtacggatac tggctcggag tatccccgcg cccgcggggt
     8941 cgacacgaaa cgggggctgc cctgtctccc ttggcgagga gcatccccgc gcccgcgggg
     9001 tcgacgcggc gcagctcgaa cagggcgtcg ccgagggcgg agcatccccg cgcccgcggg
     9061 gtcgactgca cgggagcggc ggcgggggca ccctggcccg gggcatcccc gcgccagcgg
     9121 ggtcgacttg cccatgtggc cggtgaacac ctggccgaac ggagcatccc cgcgcccgcg
     9181 gggtcgacag aacgaccaga tcggccgcct cgatcttccc cggagcatcc ccgcgcccgc
     9241 ggggtcgacg ccgtgcccgt tccctcagcc ggatccccat ccggagcatc cccgcgcccg
     9301 cggggtcgac gcgcagatca gcatcggcgc caccggcatg gccggagcat ccccgcgccc
     9361 gcggggtcga cggcgcgcac gatagcgcgc ggcacgcggt ctccggagca tccccgcacc
     9421 cgcggggtcc actgggtacg tgcgcccgca cccgtgcgca tcgccggagc atccccgcac
     9481 ccgcggggtc cacggcgccc ggccaccccc cacgccgctc atcagcggag catccccgca
     9541 cccgcggggt ccacagacgc ccccgctgcc gccgcagtgg gggcgcagga gcatccccgc
     9601 acccgcgggg tccacgcagc cacacccagc tcgcccgcca gagaccccgg agcatccccg
     9661 cacccgcggg gtccacgcgc cgccgggatg acgtgtccgt gagggccgcg gagcatcccc
     9721 gcacccgcgg ggtccacgtt gaactcggcg gcggcctggc ggacctgttc ggagcatccc
     9781 cgcacccgcg gggtccacac ttgctgagct gggggtatgt cagctgaggt agccgttttc
     9841 attcagtcgc atgaaacggc acttccttaa catgaccgcg gttcgacagt gacatccgtc
     9901 atggctcaca cggtacagcc caggcctatc cggctgctcc tcgcttatgg cggcgccgct
     9961 ccggcatgca gcgccaccgg gtagttcagt ggcccgcccg ttattcgccg aggatggtgg
    10021 cgcgtgccgc gcgtgcccag atcgcctgtt gtcgtgtggt gaaccccatg cggttccagt
    10081 ggaagatgat gtggcgagaa aggatgctcc gtaggccgag ggtgagtcgg ccgtggtcat
    10141 gggcgtcggc gagacaccgc ccggccttct ccagcccggc ggcccaggcc gccacgggca
    10201 tcagcagctc gtcgtcggcc gtgagcccgg cggtattgat cgtcaggagt ctgtggatcg
    10261 acggtgtcat ggatgacacc tgctcgccgg ggatgccggc gggtagcggg cggcttgctt
    10321 ccacgcgtgc ccagacgtcg ccctgctcgc tccattcctg gccggctgcc cgcaggagca
    10381 gcgtgaccac gaggagggac gtgaccttcg cgtcgggctg acgcgagggg ttggcgtcgg
    10441 cggtatgcaa gaaggcgagt gctccttcgc tgtctgtgtg gaagaggtcg tgagcgagct
    10501 ggatgccgac cgctccaccg aaggctgcgg tctccggctc gtacgggatg acccgccact
    10561 gctgcaccgc cccgcaggcg atcgcggcgt cgaggttcgc ggtgaggcgc gcgcgtacgg
    10621 cgcgactcga tgttgcggga gcgggtagga cgcgcagccg ccagcagggg tgcttgcgca
    10681 cgaaccacca ggaggcgatg agcccttcgt tgtaagcctg gcggagcgct ggcagcaggt
    10741 aggcggagaa cgcctcgcgg gcgcggccgt agtcggagaa ttccacgttc acctgctgcc
    10801 accgctcggc tccgtcgttt gcggaaagcg ccgccctgcc ggcggcacgg tagaggtcta
    10861 cggcgtctgc caggagcggg acggagcagg cgtgtcgggc ggcgacttgg gagaggggct
    10921 gcccggtgag ggcggccagt acggcggctt cgggcggtgt gtccatgtgg gctccgctca
    10981 caccagcagg aggctggtgt cccagtcgca ggcgggcgcg ggggtatcgg cgctttggaa
    11041 agcgagcgct gcgccggccg tcccttccag gaaacctgag ccttgcgggg gcggtgcggc
    11101 caggaaccgc tgggtgagcc ggggaacgtg ctcctggaag cggtgcgggt ccagcgcgtc
    11161 cgcggccacg cgctggacta cccgcaggag gccgccgatg ccgtggcaca gactgcggcc
    11221 ggtgagctgg tcgagctggg cggagtcgcc gatgcaggac aggagcgcct cttcgacggc
    11281 gcgttggcgg gcggaatcgt ccagggcgag ggcagcgagt tgctgagcgc gcacgatgcc
    11341 gggggttccg tagcaccagg atggtgcttc cgtgtggtgt gtggcagggc cggccgtatg
    11401 cgtccatcgg ggccaatgag tgccatggcg gtcggtttgg cgtatctggt cgagccagtg
    11461 acagatcgtc tgcattgacg tttcctggcc gggcacggtg atgccgcgca gcgtggcgag
    11521 ggcgaggagg gccaggggcc cggtgatgcc gtgtgcgagg cctgcgttgg cgtgtccggc
    11581 tggggtgggc tggtgcaggt tggtggggcc gtgccacacc caccagcccg gctgcccgtc
    11641 gggtagcggc cgggtcaggc ggaccaggta ctccaggacc cccctgaggt cgtcgccggt
    11701 cggtgcccgc cgcagaagaa gtgcgccgat gccggtgagg ccgcgcagca ggtcgtactc
    11761 ggcgaacgcg gccgggatgc cgtggtcgat gcgggtgtgg gcggccgcca ggcgctgccg
    11821 ggtgtgggcc gcgatggtgc ggtccagggc ggcgagggcg ttggcgtagc ggccggtgtc
    11881 tgcggcagcg aggtggagga cgaaggccat cgcgggagcg ccgaggaaca ggccggcctg
    11941 gtcgccgtct atgagcggtc cgattcccgt gagccggcgc tggacctcat gccaggcagt
    12001 cgttcccctg tgtgcccgct cgacgtcgag gagcactgtg ccgagtgagc cgtgggccaa
    12061 ggactgaccg gtggcgaggt ctgcagcgtg aggagtggcg gtcaccgtgc tccttcggct
    12121 cgggcggtgc tctgcacggc gatggtgcgg gccaggcgac ggcagtccgc ctccccttcc
    12181 gggtccaggc cggcggctcg gttgtggtgc atgtgcagca gggacggcaa gacatccaac
    12241 ggatcccggc ccgcggcgga gaggtcgtcc cggtaggact caagagctgc gcgccgccgg
    12301 gcccatgcgt cgatgagaac ggatccaccg ggcacctcga gcagcccgga ccggtcgggg
    12361 gcggccagat acagtgcgct ggtctggacg gcacgcgggg gcgcagcgcc ctccgcctgt
    12421 gggagaacgg acagcagcca cacccgggct gcatccgtgc tgccggcgag gacggtggcg
    12481 atgtcgtgga agctggccgc cgtcactgcc ggagcgagct cggccggtat ccgcagcttc
    12541 atctgcgcgc gggcggccgc ggagtcggcg atgaaaacct gctccgcagc tgccaacagc
    12601 cggccggtgc cgtaccggcc ggtctccggc tcgtcggtgt cccattgcac acggcgcagg
    12661 agcccgtcca ggcggagctg tgcggcccat gccccgacgg cctgcgccac gtcgccgaag
    12721 gcggcagcac cggggagctg gatgcggatg cgcaggtgcg gatcggggtc gctgtagcga
    12781 gtgaaccacc aagccggctg gggatcccag gtgtccatca gggtgggcag cgcggcggtc
    12841 agcagctcgg tggcgcgtgc ggggtggctg tagagcttga ggaacgtcca gggggaggcg
    12901 cccggcaggc ggccctcacc gcgggggacg accgtcgtgg gggtggggcg gcggacgggc
    12961 cgctgggtgg cgacgaaggg catggtgacc tcgtgcgccc gtccaagcca cccgtaggcc
    13021 gcttcaggag gcgcctcgtg cacggtcacg cggcgggtgc gctccagttc caggcgcagc
    13081 agctgctgat gggcgaggtc ggccaggtcg aggcgcaggc gttggtcgtc ggtcccgagg
    13141 aagacggtgc gggggacgcc gtagacggcc ctccagtgct cgaagcggtg cggccacctc
    13201 tcggcgccgt cacgggcgag ctcgtggtgg cgcagccgcc agcaggcggg cgacagaatg
    13261 gtgcggccga tgcggacctc gggaaggaac ggcaggctgc tagcggctcc ccaggcgaag
    13321 ggggcgagga cggcggtgtg tgagcggtgg acttccgtga cgaacctgac cagcgggtgg
    13381 gtggcgttgg tcggctcgac tgcgttcatc accgacggct cgatgatccg cccggtggag
    13441 agcgaggcca ggtacaggcg gcgggagtcg gcgccgacgc cgaggtcgtc caagtcgagg
    13501 ttggcgaccg ggttgtgctc gcccaggctc aggaggtgcg gcacgaccgc gggcgagcgg
    13561 ctgacgttct gggtacgcag ccgcaggggc gggctggaga cctgtgcacg gtccgctgct
    13621 tcggtgaggg tgggcaggtc ggtgtagacg cgctgcatgc gctcgcggtc gtccggctcc
    13681 agcaggggca ggaaccgtcc ggtggtggtg ccggcggcga gggacaggcc gacgatgctc
    13741 agctcgaacc ggccgtcgtt gagggcgtgg aggctcgggg cgtgaacgga gaagcagagc
    13801 tcgacgtgtg cgggtacctg ccacaggctg cccaccgtca gggcgtcgag gtcctcgcgg
    13861 gtgagcgcga tctcacgccg gttggtctgg gcggcgtctt gggccagggc caggaggtgc
    13921 tcgtcgcgcc gggtggtggc cagtacgggc cgcttgagga ccgagccgcg gtacccggcg
    13981 gggaagccca ggccgatgtt cgggtcggtc aggtctcgta cggggaccag ggcgcccatg
    14041 ctgtagcgct cgaggaaccg ggtgcggtag tcctgccagg ccggcgggcc agccgggtag
    14101 ggggagatcc gggcgatggc cgccagggcc gtctgggcct cgcgggccac cgcggcgggc
    14161 agtcggacgt cgcagtccgg gcgcgaggtg accaccaggg tgcgagtggc gaccccggtc
    14221 acggccgtca tgcgccgtgt ggcctcatcc cggatgtcgc gctgggcagc aggcggggac
    14281 gccaggtgtc ggcggagcag gcggcggatc cgccgcaact ccgcgactat ggccgccgcc
    14341 gccggaatcc ggtccgctct gagcaggtcc agctgctgta cgaggtggtc gaggggatcg
    14401 tcgcaggtca tgggggcgcg cagggaagta aggaggatgc ggtgggagat cagtccgcgg
    14461 acggtgttct cgacgatttc gaccggggtc gtggggtagt cgccgtgcag cttgtcgatg
    14521 atctcggcca ccgtgatcgg ggaggcggcc agcgcgagga tggtctcgat ggccttggtg
    14581 cgtcgcatgg ttttctcgac agggccttcc ttgccgggtt ggtgcggcac ggtgaccttc
    14641 gcgccgcgta tcacgtgcgt cgggtcagcg acgaccggca ggagttgcag gatgccgggg
    14701 atgttctcca gcgaggcgat ggccgcggcg agccactccg cgtctgcccg gacgtcgatc
    14761 cggtggtggg ctccccaccg ggcgtggccg gaggctccgg tacggatggg tgcggggccg
    14821 gcgaacagcc cgaacggggt ggcgcggtac cggctgcgca gcaggtaccg catcaaggag
    14881 accactgccc gtcggacagg ccgcgggcgg gcgaccttgc cgctgatcac ccctcgtacg
    14941 gcatccgcca ggagcgggct ggcgacctcg acggcggccg aggccgcctc gtcggaccaa
    15001 acctccgtga tccacgcggt ccaggcgggg acgtcgtcct gggccaggtc gggccaggga
    15061 ggcagggcat ccgtcagggg cctggccgtg gctctgagca gtgccgcgtc aagggcttca
    15121 tacattgtca tgcctccttc gtcgtcaccg gagggtgcgg ggccgagccc gacgagcagg
    15181 cccggcccgg ccccgcggga gggggcagca gcagggtcag ccgctgatgc aggtgctgtt
    15241 ggagcaggcg gactggcagg tggacccgca gccgtcgccg gtgtcgttca gcaggccggc
    15301 gacgaccggc gcggacgcga gcgtctcgat gtccaggttg aagtcggagt ccgtgccgga
    15361 cgcgtagtcc gtggccgcct tcaggacggg gttgttctgc cgtgccatct ggttcctcct
    15421 gtgaggtggt ggatggtgct cgggacacct ggtcgtagcg gcgcctctac ggccaggaga
    15481 tgatcacccg ggtgtgcggc cggtcgatga cccggccgcc ctcgggaagc ttttcgtccg
    15541 gcgtgccggc cgggtagacg tcgatgcgcg cgcggtcgtc gcggaagtcg cggtcccacg
    15601 actgcatctg aacgaccaac gcctccgcga gctcggcgcc ttccggcccg tggccgatgg
    15661 cgccgagttc gaaccggtcg gggtcctggg tccgacgcac cgtgcggtac gcgaagctgc
    15721 cgcccctgac gagcgtcggg acgccgaggg gggaggcgga cgcgatcagg ccgcgcgagc
    15781 gggcggccgc ggtgccggtg agcagaggca ggttttcgag gactgtggtc aggaacaagt
    15841 cgaggtgctc gttcgactcg tctccggcca gcgtcacccc ggaccatgct tccacgcttg
    15901 gcatgtgcag tgcctcgcgc agggccccct ggttcggctc cgggtgcccg tcgaggcgca
    15961 ggccgacctc ctcgcccggc acgtcgtgca ggagcagcaa gcggacgcgg ttctcgccgg
    16021 cgccctgcat ggggacaaag ccgcacagct cgaagccgtc gctgacgagc cgctcgccgt
    16081 cgcgcacgaa cgcgatggtg cgcgtcatgc cgcgcatgcg cagcggcacg accaggcggc
    16141 cgccgtcgac cagctggtcg atccacgtag gggggatgtc cgcggcctgc accgtgacga
    16201 tgatgcggtc gtacgggccg tcggcggcgg cgccgtcctc accgtcggcc gtcaccagtt
    16261 tcacgcgccg gtcgtagccc gtctccttga ggaagcgttc ggcgcgagcg gtgacgtcgc
    16321 ggtcgatgtc catggagacg accgtgccgc cggggccgac gatctcggcg aggtaggcgg
    16381 cgttcacgcc gccggatccg atctccagca cccgctggcc ggggtggagg tcggcctgtt
    16441 caatctgcat ggcctggatt cggggggcgg aaaccgagct gagctggatg ccatcggcgt
    16501 cggtcttggt gatcacggcg tcttccacgc cgtaggtctt ggtgatgtcc gtctgggggg
    16561 tcgcgaggtg ccggggcact ttgcggaatg ctgccacggc gccgctgctc cgaagggcgc
    16621 ccatctcgat caggcggctg accatttggt cccgcaactc ccggtcggac gccgggggct
    16681 tcatgtcggt gctcgtcatg cgggggacgc tatccatgct ggttctcctt ttggcccaca
    16741 tgtgctggga aggctgagag cgcgtggttt ggtccggagg aaggccacac tcctcactgg
    16801 ggtgggcgcg aggtgtcttg cacacgccgg gcgctccggc aggcagttcc cggaccgccg
    16861 accggtcacg cagcgcagca cagctgcgtt gcccttccgc tccggcgagg tgcggcagcg
    16921 catgctccag cctcgctgcc aagccgcgca ccggtcacag ctccgtgagg ggcaggggga
    16981 gctcggcgcg tagggtcttg ccggggcacc cgacgtcgag agaccagctc accgccacgc
    17041 ccagcctgcc gacccgccgc aggcccagaa gccgcctcgc agcccgcagg cccgaccggt
    17101 actccaggag catcggccct cccacgtcca ggcacagctc gtccacaacc gggtagtgcc
    17161 gtgaccgggc cacaagctcc agttcctcaa actgcgcgcc ggcctcccgc tcgggcgcct
    17221 gcacgtagcg cacgaccttg agcatcagac tgttccggcg ggcaaggctc gcagcggccc
    17281 gcactccgtc cgtgcggaac ccccacagcc gtgtcagcgg tgctgcctgc cggatcggcc
    17341 tgctggccag cggcgaccac tgccgttgca gggcgttgtc ccgccccatc ccgtcacgga
    17401 ccgcggggat ctcggtcaag tccacggcac gccctcctcc tcaattgccg gtacagggcc
    17461 gggcttacgg cggagggatg gcgccctcct ggcccgaccc cacacccgtg ggggtgtgca
    17521 cggtagtgag gggaggcgca tgccctggcc ccgcgcacac ccttagtcaa cgcccggtca
    17581 cagggtgcgg gtagggcgat ccggggcggg cgacgctgtc tcccccaggg cgatttgacc
    17641 cgccctttgc ctgcgcctgt cctcgcgttc aacctacggt tggcccgtgg acccaaggcg
    17701 aaacgacgcc ttagtggcgt ggatggctga gaagcggctt ggctcgcgcg agcttgccga
    17761 cctggtcaat gccgctgtcg gcgagatcac cggccgtgtc ggaggcctgg acgactccaa
    17821 catccgggca tggcggtcag gccgggtccg ctgccccaag ggggcgcagc tccgggctct
    17881 ggaactgctc tccgggctgt cagcagctga cttagggttc gtgcgccggg cccgcctgcc
    17941 ggcccccgac cccaaccagg agccgcccgt ggaacgccgt accttcctcg ccttccccgc
    18001 cgctgccgcc gcggcagggg tcccttcgcc ggcctccgct gcatcaacag cccgcgtggg
    18061 catgtccgac gtggcacgcc tccaccagcg gttcaccgac atcatcgcct ccgaccaccg
    18121 gcacggcggc caggccagca tcgagcacga ggccgtccgc ctagcctctg aagcactcct
    18181 cctccagaag tccggcactg catcgcagcg ggttcgaacg aacctgtatg cgacggcggc
    18241 ttcgttcatg tcctcggcaa tgtgggccgc catcgacggc cgccggttcg gcgatgctcg
    18301 caaccacctg cggcacgccg cgcagctcgc cgaactctca ggtgatccgg cgatcaagtt
    18361 ccggatctgg tcgcacgcgg gaaccatgta ccgccatcag ggcagtccgg ccgaggcagc
    18421 ggccgccaac aacgtcgccc gcggcctgtc cctcgcccgc cgcgaccccc tgttcgcctc
    18481 gctcggcctg gcccggcacg ctgctatcca cgcggctgcc ggcgaacgca gagcggttcg
    18541 gcgtgcgttc ggacatgccc aggaagcgat ggcccgcgcc aaccgcggcg atgtccgccc
    18601 ggtgtggctt acggcgttct tcgaccaggc cgaacttgac tctctcgcct tgtcggcata
    18661 cctcacgctc ggggactggg cgatggcgga ggcccacgga caccgctgcc tggcagctct
    18721 gcgccctcac atgcgcaggt cgaaggcgat caccacgtcc cgcctggccc ttgcgcagct
    18781 cgaacagggc gacgccgaat cagccctcgc gaccgccatg agggtccctg ccgacgctgc
    18841 ctcccgccac ccccgcgtgg tcggcatgct cgataccttc ggccgccgcc ttaacgcgat
    18901 cgccccgcag agcgcccacg aagccgcctg gcgggagttc atcaccagga aggatcacac
    18961 cgcatgacca cgtctgcacc cgccatacgg cggcacgcga cgctcacccc ggccttgaag
    19021 gccgtgatcg gagacctgta cgccctggtg cgcgccgatc tccttgacca cccgaactac
    19081 cgcctggacg tgttcctgga gcggctggac cggcacgccg ccgaaccggg ttgggccgtg
    19141 gtcatcgcgc acggctccga cgccgccccg gtcggctacg cctatgccaa cagtgtgggg
    19201 ccgggtgacc ggtggtggaa gcggctgaac tcgccggctc cagtccggta cacaggcaag
    19261 gacgccgtgg ctgtcaaaga gatcggcgtc atccccgcct ggcgcgggat cggcgtatcc
    19321 cgacatatgc atgacgcgct actggccgac cgcggcgagc cccacgcgac gctgatggtg
    19381 aaccccgttg ccggcgatgg gaaggtgatg cgcctgtacg agggttgggg atacgaggag
    19441 atcggtgtgg tgcagccttc cccagattca ccgtggctgg tgtgcatggg acgccctctc
    19501 cgcgcctgac gaatgcgccg gagcggggat gcggcgcggg gtcgacagct cgacgacgct
    19561 tggcatgcag ggcctccatc ggaacatccc agccgggcgc ggggtaacgg ccgaaccagc
    19621 cgcggcgccg gatccggtcc gcggcagtgg ccgacatgcc gcggtgcgct gccgcaaagc
    19681 tttgggcagg gccgggcggc tccgttacct tcgcgacccg acgccccaag cctcctctgg
    19741 ccgggcggcg tgctgttccg caggccgaaa gggcccgaga ggcgtggaaa caacctcagg
    19801 cgcaggacaa gccgaagcac gggagaagac gggatggagt ttgcccggcc ttctcttcgc
    19861 agggggttgc cgtcgtgctc cgtcacacca ccgtgtggtc gtggtggacg ctgctgtggg
    19921 ggccgctgcc gttgctcggc gccgccacgg cggtgcacga gtggcggctg tcggcgcgca
    19981 aacggtggcg gatcggcgtc atggaatggc ttgccctcgt ctgggcgaac ttcggcttcg
    20041 cggtgtgcct ggcgggcgtc tgggtgctgg gctgaccggt tgtcagggcc gcgccgcggc
    20101 gtcgtccgct tcggcggcgg ggggcttcgc gtagaggatc tcgcgggcct gctccgcggc
    20161 gcggacaatg ctctcggtga cgaagtcgac gaagcgggcg atgttctcga ggcgggcggc
    20221 cgccggggtg tcggggccga ggatgccgac gccctggcgg gcgaccacga cgagttgggc
    20281 cgtggaacgg gcgctggcca gcatcgactg gtaccagacg tcgttgtcga cgatgtagcg
    20341 ctcgcggcgg cgttcgtctc gctcgcggcg tacgaggccc tgctcctcca ggaacgcgat
    20401 cgccttggag acggacgccg ggctgacctg gagccgctgg accagctcgg ccgcggtgag
    20461 gctgccggcg tcggtggtgt acaggcacac catgacacgg gccatcatct tcgggacgcc
    20521 cgatcccacg aggacggtgg tgaactcctc ttcgtaccgg cgtacttcct cggagtcgcg
    20581 gccgtggggc tgcgggggcg tcggcgcgtt gcgcggggcc ggcttcctgc ggcgctgggc
    20641 gcgctgctcg gtggcgcggt gcgccaggtc ggcgcggtag gcggtgtggc cgccgttgcg
    20701 catgacttcg cgcgtgacgg tcgaggtcgg gcggtcgagg cgccgggcga tctccgcgta
    20761 ggcgaggccg tcggccagtc cccgtgcgat ctgctggcgt tcctgctggg tgagcctgcc
    20821 tcccggcatg gcgcctcctt tgcgttgcgg gactccagta tagcgtttgc ccgcagttca
    20881 ttgcaacgac cgccgggtga tcgttgcgtt atcttctgcc tcggtgcaac gattgcaggg
    20941 ctctgagctg ccaaaatgac cgcttctcgc aatgtgttga ttgcctacat ggaaaacgca
    21001 acgtagcttt tctcatgtcg gaaacagcgg gccgcaaggg cccgccgacc cactccaggg
    21061 agaacgcagc atgcagacct tcgccacccc cgcccccgtc tccgtcgtcc tcgacgtccc
    21121 cgcgggcagc atccgcttca tcgccgcgga ccgggccgac accaccgtcg aggtgctgcc
    21181 cgcggacgcc tccaaggagc gcgacgtcac cgccgcccag gagacgacgg tcgcctgcac
    21241 cgacggcgtc ctgaccatca ccacgccgaa gaagaagggg ctcctggccg gcgccggctg
    21301 cgtcgaggtc accgtccggc ttccggccga ctcgcacgtc gaggccagga ccgcctcggc
    21361 cgagttccgc ggcgtcggac ggctgggcga ggtcgcctac gacagcgccc acggcaccgt
    21421 caagctcgac gaggtcgccg ccgcccgcct caccctccag gccggcgaca tcaccgtcgg
    21481 cctcctcggc ggaccggccg aactccgcac gcagaagggc gacctgaccg tcaccgaagc
    21541 ccgccgcggc ccgctcaccc tgcgcaccga gcacggcgac atcaccgtcg gcgccgcccg
    21601 cggcacctcc gcctccctcg acgccggcac ctcctacggc cgcatccaca acgccctcgc
    21661 caacgccgac ggcgacgccc cggccctgcc catccacgcg accaccgcct acggcaacat
    21721 caccgcccga accctgtgac accccaccgg ccgcacggcc accgaggccg acagcgctcc
    21781 cggcgccgag gggcgccggg gcgcgccgtc acacctgcac cccgcactac gcgccggccc
    21841 gcccgcgctc cacatgggcc gtgatgcggg cgatcgtggc ggcgttgtcc acgaagagat
    21901 ggccctgcat gcccgccgcg cgggccgcct cgacgttcac cgccacgtcg tcgacgaaga
    21961 gacagtcctc gggccgcacg cccaactggg cgcaggccgt gccgaaggcg cgcgcgtccg
    22021 gcttgccgac gccgatctcg tgcgagtaga cgatccgctc caccagccgg tcgaagccgt
    22081 agcgggcggt ctcccgctcc cgggcgccga cgaagctgtt gctgaggatg cccaggcggc
    22141 atcttccgcg cagcccgtcg acgtaggcga tgagctcctc gttgggcgtg cccaggtact
    22201 cggcccacag gtcggccatg aaggcctcgg cgtccgccgc gtcgaggccg aggcgcgtgg
    22261 ccgcctgttc gtgcacgtcc ctttcgctga tcgccccgac gctgccggcc tgccagacgc
    22321 cgcccatccg ctcgtccacg gtgcccggcg gcagccgcag cttctcctcc caccgttgca
    22381 cccaccccgt ctccggggtg aactcgagaa cgccgccgat gtcgaggatg acgcaggtcc
    22441 cggtcacaac aaccccctcc ccgcgctgtt tgcgcgtgat ccagggaaca actgtggccc
    22501 agcccccggg aacgcccaca gtgacgccgg tcacggcgct ggtgacgtgc gagggcccga
    22561 ccgcgccgac cgtggtacac cgggtgttcc ggcggtccgc cctgtatccg gcggtctgcc
    22621 ggtacaggtt gccccgtgga accggcagcg agcacgtgaa ccgtggcacc gaccaggacg
    22681 gcggagacgt ccctggcgcc ggcgccggga acctggtgtc agccggaccg cttgccggtc
    22741 gaaggaacga ggtccggccg tggacgcgcc cgcccgcaag gggataggcg cggacagaat
    22801 ccccatcgct gaccgcgcgg gtgcgggcct cggccgggtt cgtgcccaac gccgaacagt
    22861 cggccgcggc cgcgcagtcc tcggctgacc gggcgaagca ggcggccgtc accgcgcata
    22921 cggccgcgcg ctcggtgaac tactccgcca accgcgctgg agttggcact ggtggccggc
    22981 ggtccggtgt ggacccctcg atcggtcggt ccgccgtcag caccgtgcgg accggaatcg
    23041 gcttgcgggc ctcccagctc cacggtcggg acgtcgtttc cgtcgttttg cgccattccc
    23101 aaggtggcgg ctgccaagcg gagctcatgt gatcaaatga ctccatgggg gatacacgca
    23161 tggcgctggg gccgctggaa cctgtcgaag gtgtctgggc ggtcggggac gctcaccggc
    23221 ctggcggatc gtggctcgag tgccgtgagg aggggatgtt ccggcaagca cccgagggaa
    23281 gcgagctgat cgcgtggtca aggatcatgc tcgggatcgg cgtctacatc gggcgtggat
    23341 acccccgctc aggtgatttc acgctgttgg gtttggccag caacatgccc ggtcctttca
    23401 gagggcgtgg tggaggccac ctcgacatga cgctccgcca cccctacgag gaccggaagc
    23461 tgaccttcac ccggcacgca catgcgtacc ggatcatcga cacgttcctc ttggcaagcc
    23521 tcctgtctca gctcgtcgag gcgggtgagg cacaccgcct cggcgacccc gaatggctga
    23581 gccgcgtggt cggccgcctg acgccgctga gcccctggct cacgcgcaac aggctcaccc
    23641 aagcggtgga gcaggcttgg caggtctgat ccacgtggcc gccgccacgg gccacccggc
    23701 cggcagcccc tggcgagtcc ggcgccctgc gctacaccgc cggcctggac ggccgcgcag
    23761 acgagaacgc gggcagctgt gagggagtaa gcggtcgtcc cttgaggcgt gccctcctgg
    23821 accggacaac ggtcttgagg cgtggtgcat ctgtggggta gtcatgtgct cgccccgcgt
    23881 agggctgcat cggtggaggg ggttgcgtgg aaagggacgt ggagtgggag cgcagcgctg
    23941 agcggtgccg aacgcgtacg agcgggtcct cgcggaggat cgatggatga tacgggagaa
    24001 actgcgtacc agtcgcggtg ggggcgcacg tcgccgtctg gtttgcgctg gctctggccg
    24061 tcgtccgccg gcgcggcggt cgggtcccgt aggcgatcga gcgggcatgc accgcgattt
    24121 tcggctgggc ccagtggctc tgacctggcc tggcctggca tgacctgatc ggaccggtgc
    24181 gggggctggc ggaggctggt gcatgccgct ctccgcgcat gtccgatcgg cgagccgccg
    24241 gtttcccgat cggcggcggt catacggcag gggagggcga gggcaagggc gggggagccg
    24301 gcatgggttg gggtgccgcc ggcagcggat ccccgaaggc ttcgcgggcc gtggcgagca
    24361 ccgccgcggc gaggccgcgt gcggcccccg ccgtacggcc gcggatgcgg gacggccggg
    24421 ccgcgaggcc gtgcgtccgg atgtccgcgt cgtgcgggag gtgcaccacg gccgcggtgt
    24481 gcggggccag catcgtcgcg gccgcccggg ccaccgccgg gaggcgcccg tccgaggcgg
    24541 cggagaacgc gacgaccgtg cgctgcaggg gcatcccttc gcagtggcgg aggacctcca
    24601 cggcctgttg cagccggtgt acgccgcccg cggtggactg tgcgcacagc acgggcacgg
    24661 cgtacgggag ggcgcaccag ccgcgggtca gccccggcag gcccgcccag tcggccgcgg
    24721 tgatgtcgag cgcgacgggg tgggcggtgt cggcgacgag gacctgccag ccgccggcgg
    24781 cggccagttg gtaccaggcg gcggggtcgg cggggagggg cagtggggcg gcgctccact
    24841 cgcggccgtc ggtcagcacc gaccacctgc cctcggccgc cggccggacc gcggccgcgt
    24901 cgcggatctc ggcccggctc agcggccggt ccggcggaag ggccccgaga ccgccgccgc
    24961 cctgggcgcc cgccgtccag gccggccagg gggagcagag ccgcgccgac aggtcggcga
    25021 cgaccgtgtc gccgagccgg gccagcgcgt ccgcgagcag gcaggccacc gtcgaccggc
    25081 cgctgccgcc gccggcggcc atcacgggca ccacgaggcg cgccgattcg g
//
