LOCUS       NZ_CP030862            22673 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces globosus strain LZH-48 chromosome, complete genome.
ACCESSION   NZ_CP030862
VERSION     NZ_CP030862.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globosus
  ORGANISM  Streptomyces globosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Draft genome Sequence of streptomyces globosus LZH-48
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Institute of Biophysics, Dezhou University,
            566 DaXuexi RD, Dezhou, Shandong 253023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Portal v. version 2.2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003325375.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:22:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,671
            CDSs (total)                      :: 6,576
            Genes (coding)                    :: 6,458
            CDSs (with protein)               :: 6,458
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 41 of 118
            Pseudo Genes (incomplete)         :: 101 of 118
            Pseudo Genes (internal stop)      :: 11 of 118
            Pseudo Genes (multiple problems)  :: 32 of 118
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:39:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3640478
            Orig. end                         :: 3663151
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030862.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22673
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="20"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22673
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22673
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12673](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12673)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            221..1786
                     /locus_tag="C0216_RS15840"
                     /old_locus_tag="C0216_15815"
     CDS             221..1786
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (99-263). E-value:
                     3.4e-11. Score: 35.1. Matches aSDomain:
                     nrpspksdomains_C0216_RS15840_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008736942.1"
                     /locus_tag="C0216_RS15840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15815"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_246042823.1"
                     /sec_met_domain="PF00561 (E-value: 3.6e-14, bitscore: 51.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAGLLVTGSLLAAPAAQARSGTDASATPGAPLGTAARTVGDASY
                     TPGACPKTPEPIEELEGARCGTLTVPENRSEPDGKKIKLGVAIVPALSAAPKPDPIVWL
                     AGGPGDDAVGEAEMAIGGGLNRDRDVVLMSQRGTYSAEPNVLCPNIDEFNARAVGLVSG
                     APSTERLHVEATKACRDRLAAQGTDLAAYNDTESAADYEDLRAALGLKQWNLYGISYGT
                     HLALVYMRLHPGGLRSVALDGILPPSIAGSAATWSSARQGFDGVFKACADQPACNKRYP
                     NLSATFDRLVRDLEANPVTTTVTLPGSDKPVKVVLDGGTLVNWMTSATHIAPQVPLAID
                     ELAHGKPQRIAAQYAGGKLSPAAVGRVAHGLVYGVFCSEWTPYETEEEALEGGRKAFPT
                     YPRPVLEQAPQLAFLRSDCDVWDVPPADPSIRDATRSDIPTLALSGSFDAQTGADNGPY
                     VARTLPNATIVTVPYEPHVVFATSKCAQQIAVSFFDTPDAPDTACLKGLEAPRFEIGEP
                     GSTG"
     aSDomain        518..1009
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C0216_RS15840_Abhydrolase_1.1"
                     /evalue="3.40E-11"
                     /label="C0216_RS15840_Abhydrolase_1.1"
                     /locus_tag="C0216_RS15840"
                     /protein_end="263"
                     /protein_start="99"
                     /score="35.1"
                     /tool="antismash"
                     /translation="PIVWLAGGPGDDAVGEAEMAIGGGLNRDRDVVLMSQRGTYSAEPN
                     VLCPNIDEFNARAVGLVSGAPSTERLHVEATKACRDRLAAQGTDLAAYNDTESAADYED
                     LRAALGLKQWNLYGISYGTHLALVYMRLHPGGLRSVALDGILPPSIAGSAATWSSARQG
                     F"
     gene            complement(1802..3217)
                     /locus_tag="C0216_RS15845"
                     /old_locus_tag="C0216_15820"
     CDS             complement(1802..3217)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017949629.1"
                     /locus_tag="C0216_RS15845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15820"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_114055915.1"
                     /transl_table=11
                     /translation="MKHTPGERPTDPTRRALLTATAGVGAALMAGCARGAAPGAPAPTP
                     TAAGSASPTAGAGGITPGAMTLFQDPAYNFSALLALGASGAGAAEVGEVLTAVNTVNAA
                     GLSPQTYVETFRKLGDRLLRPPPGAPADDQTKRFRALRAAQYYGQALFFVLGSDAPGSE
                     EQLYRSGRKAWDAFCDLCEPAPVKAQVPYGTTPLPVWFFRPDTSGARRPTVILTNGSDG
                     QNVDMWTYGVPAALERGWNALVYDGPGQGRLLFVDRIVFTPTWEKVVTPLVDWLTARSD
                     VDPDRIALTGLSMAGDLAPRAAAFESRIAALVAMPGCVDPWLGFPPEIRRILTPDKQQT
                     NDIWNNEVVPELPPAAAATMKKRFEPFSIPAMLEARQGRLFTDFYTPATRIQALKITDV
                     VPLIKAPTLVLDYEGEQFYPGQPREMYNALTSPKDYVRLTAQEGAQLHCSPMAPQLHCE
                     VVFDWLQQTLQGS"
     gene            3531..4337
                     /locus_tag="C0216_RS15850"
                     /old_locus_tag="C0216_15825"
     CDS             3531..4337
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010470403.1"
                     /locus_tag="C0216_RS15850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15825"
                     /product="serine protease"
                     /protein_id="WP_246042824.1"
                     /transl_table=11
                     /translation="MHSVRRRVARTTVVGTLVAAACATLLAGSAGAIVNGSDAGEHYPF
                     MATIPESAPKYGLHDGNCGASLIDPRWVLTAAHCVQGDGLELEGTVRIGSRHRKSGGTV
                     RAIDRIVVHPGYANGEGKAFNKHDIALVRLDRPVAGKPVRLAEGAGRPGTPTRILGFGT
                     TVDTELRFAERLQELDTRIGAEAECAPGYADRTRLCTISRVPEAMACFGDSGGPQLQRG
                     RHGRWELVGVTSGPGAPGVACSDGPGLYAGVPVYRDWIRKTVRRDA"
     gene            4788..5609
                     /locus_tag="C0216_RS15855"
                     /old_locus_tag="C0216_15830"
     CDS             4788..5609
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126327.1"
                     /locus_tag="C0216_RS15855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15830"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_114055917.1"
                     /transl_table=11
                     /translation="MTILVTGATGTLGRLVVERLRQGGERVRALTRTPAAAGLPDGVEV
                     VGGDLTRPQTLAGAFDGVRAVHLLGATGHDHTPLETGPQVVAMAAEAGVERLTVLSAGE
                     DGPWEGTVRASGLEWTFVWPIDFMANTLGWAGAIRTAAEVREPYAGRRTASVDEADVAD
                     VIAAVLTRGGHAGRRFTVSGPEALTPADKVSAIAAATNRALRFTGLTDEQARRQWRAEG
                     WPEEGIAFVLHMWATVPDTVAEVTTAVEEVLGRPPRTFARWASAHAAAFRP"
     gene            complement(5623..6306)
                     /locus_tag="C0216_RS15860"
                     /old_locus_tag="C0216_15835"
     CDS             complement(5623..6306)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS15860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_15835"
                     /product="hypothetical protein"
                     /protein_id="WP_114055918.1"
                     /transl_table=11
                     /translation="MFVTENGTGTAVLLVFGGVLLLLALFGSRLEGLEVGGVSLRLRAA
                     AADRLALAEESERQGDVASARRLRAEAQVLLDSAAPAAADRTPVRRTAHRGVPRTWATE
                     EAASRDRRSAEEREHEPADVLSRFREGTAEERITALAAMQADRALRDVDAAVTAVEDPR
                     SPLEQHQALLLAAHMADDLDEAQARRLADAVRAQRDRRFRRDSDLWRLAEAILRRLEAG
                     RPQDG"
     gene            complement(6429..6956)
                     /locus_tag="C0216_RS15865"
                     /old_locus_tag="C0216_15840"
     CDS             complement(6429..6956)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612781.1"
                     /locus_tag="C0216_RS15865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15840"
                     /product="DoxX family membrane protein"
                     /protein_id="WP_114055919.1"
                     /transl_table=11
                     /translation="MTWINRRDLALLALRAGTGAVLMAHGTQKLFGWFGGGGLDRTAAA
                     MEHMGFTPGRRSALAAGLGEAGGGALLVLGLATPAAGAAAAGAMAGAVSVHAPAGFFAQ
                     AGGYEYPAFLGFTAAAIGLAGPGRLSLDHATGHTFDQRWMLALAFAASAAAAAAVVAKR
                     AQAPQDTGEEPS"
     misc_feature    6943..6956
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            complement(7186..7596)
                     /locus_tag="C0216_RS15870"
                     /old_locus_tag="C0216_15845"
     CDS             complement(7186..7596)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975554.1"
                     /locus_tag="C0216_RS15870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15845"
                     /product="four-helix bundle copper-binding protein"
                     /protein_id="WP_114055920.1"
                     /transl_table=11
                     /translation="MNAPVKDMLHSYPADLGDLDQDRLARCIEECIACAQACTACADAC
                     LAEGMVGDLTKCIRTDMDCADICTATAAVLSRHTGYNPDIARALVTACAVACRACADEC
                     AAHADQHEHCRLCAEACRSCAEACSDLAATLG"
     gene            complement(7715..8512)
                     /locus_tag="C0216_RS15875"
                     /old_locus_tag="C0216_15850"
     CDS             complement(7715..8512)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031829.1"
                     /locus_tag="C0216_RS15875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15850"
                     /product="ABC transporter permease"
                     /protein_id="WP_114058697.1"
                     /transl_table=11
                     /translation="MRRELRAVHALVHRDLLRLAAQPTHAALVLFQPVLYLFILGGGLA
                     ALIPDSSLGTGYQAYLFPGMLMMTVQAPAIMVGVRLITDRQSGYLRELLMAPVRRSTLL
                     LGSCAGGTLVATVQGALLLCLAGAVGLPYDPVLMALLLGGMVLASFTITALSLALAVSL
                     HRPEVFHMLLGLVMMPLMFLSGGFFPLQNLPGWARALADANPLAYGVDLLRGCIALRVP
                     DQAAVGGIDWFGRQPPLLLEAGVLLAAGAAALLWAAHRFSRPE"
     gene            complement(8584..9672)
                     /locus_tag="C0216_RS15880"
                     /old_locus_tag="C0216_15855"
     CDS             complement(8584..9672)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845680.1"
                     /locus_tag="C0216_RS15880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15855"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_114055921.1"
                     /transl_table=11
                     /translation="MQPHAGAGAPAQAAPAPAPRTSPDSAHDAAGTAYAISTRGLVKTY
                     PGPDGTATRALRGLDLDVHRGETFAFLGPNGAGKSTTIALLCALARPTSGRATVAGADI
                     LTEPDRVRRRVGMLFQHSALDPDLTAEQNLHIHARLFGLSRRDARRRTAETLEAVDLAD
                     RRRALVRTLSGGMRRRLELARGLLHAPEVLFLDEPTTGLDPHARAQVWQHLRALRDRQG
                     STLFVTTHYLEESEHCDRLAIIDGGRLVAQGAPAALKAAIGDDRVVLRTSDDATARRIV
                     CEATGSPDPAVTADAEGVWLRVPDGSAWIPRLCAALAGRGISVHAASAAPPTLDDVFFH
                     HTGRSINAARPDLTPDAPGSAP"
     gene            complement(9802..9957)
                     /locus_tag="C0216_RS33890"
     CDS             complement(9802..9957)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104907.1"
                     /locus_tag="C0216_RS33890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VenA family class IV lanthipeptide"
                     /protein_id="WP_174250405.1"
                     /transl_table=11
                     /translation="MENRDFELLAHLHALPETDPLGADGAAFADTCQCVGLLTLLNTVC
                     VGVSCA"
     gene            complement(10001..12673)
                     /gene="lanL"
                     /locus_tag="C0216_RS15885"
                     /old_locus_tag="C0216_15860"
     CDS             complement(10001..12673)
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955211.1"
                     /locus_tag="C0216_RS15885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15860"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_114055922.1"
                     /sec_met_domain="Pkinase (E-value: 1.3e-17, bitscore: 62.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.5e-45, bitscore:
                     152.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSHATEADLESLLHDALKATDTETRWAVDADDMWCRLTPGSATP
                     RTQGWKLHVSATAASAPEVLARSLDVLLREESAFKFARSLEQVSALNTRATPRGSSGKF
                     LTVYPSSDADAARIAQQLHRATAGLAGPRILSDQPYAAHSLVHYRYGAFVGRRRLSDEG
                     LLVWYIEDPDGNPVEDKRTGQYDPPPWAVSPFPPSVPAPPRTEQTAASPVLLGGRFSVR
                     EAIRHTNKGGVYRGTDVTTGAPVVIKETRPHVEADASGSDVRDWLRAEARTLEKLRGTG
                     LAPEPLAMFEVGGHLFLAQEEVPGIPLRTWVAEHFRDSGSEQYRADALAQAVRLAELVA
                     AAHARGCVLRDFTPGNVMVRPDGELRLIDLELAVLREDGALPTRVGTPGFSAPERLADA
                     PVSPTADYYSLGATICFVLAGKVPNLLPEEPAGRPAEQRLAAWLTACTAPLDLPPALQE
                     TVLGLMKDDPAERWDPARALTALRATALMRPARPAAAPQPGGTAADEVDAAIAGMVDHL
                     VDTMDPADDRRLWPVSTMAGEADPCTVQQGAAGVLAVLTRYFELTGDPRLPGLISTAGR
                     WTAARTDTRSTRPGLHFGGRGTAWALYEAGRAVNDSALMDHALALALAPQDPTPSHDIT
                     HGTAGSGLAAAHLWYRTRDPRLAGLVTDAADRLAAAARREPAAVSWPVPAEAVSAEAGK
                     RYLGFAHGTAGIACFLLAAAAVTERQQHRDLALAAGEHLAACAVRVGDAVHWPAHTADL
                     PTAPYWCHGSAGIGSFLVRLWQATGDDRFRNLAHGAARAVVQRASRAPLTQCHGLAGNG
                     DFLLDLADATGESSYRAMADDLARLLVAERARRGSHVVFPNEYGEASTSWSDGTAGILA
                     FLLRVRHTEPRHWMVQQPV"
     misc_feature    12632..12643
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.88"
                     /tool="antismash"
     misc_feature    12671..12689
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.52"
                     /tool="antismash"
     misc_feature    complement(13179..13195)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.12"
                     /tool="antismash"
     gene            13701..13952
                     /locus_tag="C0216_RS15890"
                     /old_locus_tag="C0216_15865"
     CDS             13701..13952
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007263001.1"
                     /locus_tag="C0216_RS15890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15865"
                     /product="UBP-type zinc finger domain-containing protein"
                     /protein_id="WP_246042825.1"
                     /transl_table=11
                     /translation="MLRPVRHVGKGCEDCEAGTPRVGLLRCLTCGHVGCCDSSPGQHAH
                     AHAEASAHPLAQSCASGARWAWCYPDGLYLVPAAPAPR"
     gene            complement(13998..14174)
                     /locus_tag="C0216_RS33895"
     CDS             complement(13998..14174)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452666.1"
                     /locus_tag="C0216_RS33895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6480 family protein"
                     /protein_id="WP_174250406.1"
                     /transl_table=11
                     /translation="MSNLRIPPGETPPAEGSTASAHRERADGGPWEHPGVFLALVVLGA
                     AMVAAFFAARLWG"
     gene            complement(<14377..14928)
                     /locus_tag="C0216_RS15895"
                     /old_locus_tag="C0216_15870"
                     /pseudo=""
     CDS             complement(<14377..14928)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012334.4"
                     /locus_tag="C0216_RS15895"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15870"
                     /product="SDR family oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNVPGGGARVLVVGATGEIGTLAVRGLAGRHCRTALAGRDRRRLA
                     ALAAGTGSPARRIDAYDLRGCSGLAPWAAEALGGLDGVLVTVGVAAFGPAARVSDAAAE
                     HLLTVNALCPMAVLRGAAPVVGDGGFLAAVTGAVVDTPLAGTADYAASKAALAGWLGVL
                     AREVRKRRVAVVDARFPHLDT"
     gene            complement(14925..15461)
                     /locus_tag="C0216_RS15900"
                     /old_locus_tag="C0216_15875"
     CDS             complement(14925..15461)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004936618.1"
                     /locus_tag="C0216_RS15900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15875"
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_114055923.1"
                     /transl_table=11
                     /translation="MSLRDELPVDHPLNRVYRIGAALCGLLLLLFGCLGYADSLSAFDT
                     DGQQIAGLSTNGLLSTVSVVFGLLLVVAALIGGNVASSVNIAVGVLFLLSGFVHLFLIG
                     RPGNILDFGLSNVFFSFLMGLLIMTFGMYGRVSGGLPHDNPYWRRRHPDQAARETAGRP
                     RLGPAAGRPAELPRR"
     gene            complement(15597..16283)
                     /locus_tag="C0216_RS15905"
                     /old_locus_tag="C0216_15880"
     CDS             complement(15597..16283)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324178.1"
                     /locus_tag="C0216_RS15905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15880"
                     /product="adenosylcobinamide amidohydrolase"
                     /protein_id="WP_114055924.1"
                     /transl_table=11
                     /translation="MSAVIPPPRPATGLLPVQPLDRLEGGERLHGLLWRAGADWRMISS
                     AVLGGGIGERAWVLNAQVSHGYRRTDPERHLAELARDAGVRGPGVGLMTAADVRAYGHA
                     HDAGAEAVATAGLGVRGWAAAPGQGAAAAPQPGTVNIVVALPVALTDAALVNAVATATE
                     AKVQALLDAGYDCSGTPTDAVCVAARVPRGGEDAHPFAGPRSLWGARLARAVHRAVHAA
                     ARPPAA"
     gene            complement(16417..17067)
                     /locus_tag="C0216_RS15910"
                     /old_locus_tag="C0216_15885"
     CDS             complement(16417..17067)
                     /GO_process="GO:0007155 - cell adhesion [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514771.1"
                     /locus_tag="C0216_RS15910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15885"
                     /product="fasciclin domain-containing protein"
                     /protein_id="WP_114055925.1"
                     /transl_table=11
                     /translation="MNTIRIRRTAVAVAAAAVLPFSLAACSDSGSETKAAPTAGAEGAA
                     QTAGSAPMDDAATGGKPFGPGCASVPEEGAGSFEGMAQDPVATAASNNPALSTLVAAVK
                     QAGLVDTLNNAKDITVFAPTNEAFAKIPKADLDKVLADKAALTNILTYHVVGQRLTPQQ
                     LENGSFETLQKGTVTTKGSGESYKVNDTAAVVCGNVKTANANVYIIDTVLMPK"
     gene            complement(17075..18742)
                     /locus_tag="C0216_RS15915"
                     /old_locus_tag="C0216_15890"
     CDS             complement(17075..18742)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018561954.1"
                     /locus_tag="C0216_RS15915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15890"
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_246042563.1"
                     /transl_table=11
                     /translation="MSSFRNTLARVGPGALAGLLAAFAALAAAELAAGLARPAAGPVTV
                     VGGAVVDLAPAAVKDFAVRTFGEDDKDALRLGILFLLALSAAGLGVLSLRHLRAGAAGV
                     LLFGAVGAAAALSRPDAAGLGDALPSLAGAAAGAATLCFLVARRAGAPPDGPAGSGRGD
                     WNRRGFLTAAAATAGAAASAGALGRTLADRHGQDAAASRNALVLPPPASPAPALPAGAQ
                     LKVPGISPFTTPTRDFYRVDTALAVPRIDAGTWRLRIHGEGVTRPRTLTLGELLARPLV
                     ERDITLTCVSNEVGGPYTGTARWLGVPLADLLREAGVRPPSQGGRSDQLVARSADGMTL
                     GSPVEELMDGRDAMLAVGMNGEPLPFDHGFPARMLVPGLYGYVSACKWITDMELTSFDA
                     YDPYWVRRGWARRAPVKTQSRIDTPKPFARPAAGPVTVAGVAWAQRRGIIRVEVRIDDG
                     PWQDADLAAPTGADTWRQWTYRWEAAPGGHTLTVRATDGTGRVQTEERTRTVPDGASGR
                     HSVFVTVPQTTGRPARGPAGAPPRPPDNRTAVQPSLKE"
     gene            19131..19718
                     /gene="sigK"
                     /locus_tag="C0216_RS15920"
                     /old_locus_tag="C0216_15895"
     CDS             19131..19718
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene="sigK"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952779.1"
                     /locus_tag="C0216_RS15920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15895"
                     /product="ECF RNA polymerase sigma factor SigK"
                     /protein_id="WP_246042564.1"
                     /transl_table=11
                     /translation="MNQPLPSGAGHAPGGADLAELMQQVARGDKQSFSALYDALAPLVH
                     GIVVRVVRDRAQSEEVAQEVMIDLWRQAARYRPDTGSVTTWAATIAHRRAVDRVRSAQA
                     AADREHTQAAREHQTAFDEVAEQVETRLESEQVRRCLRGLTELQRQAVDLAYYRGLTYR
                     EVAEALRTPLPTIKTRMRDGLIRLRDCMGVTT"
     gene            19715..20467
                     /locus_tag="C0216_RS15925"
                     /old_locus_tag="C0216_15900"
     CDS             19715..20467
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952780.1"
                     /locus_tag="C0216_RS15925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15900"
                     /product="anti-sigma factor"
                     /protein_id="WP_114055927.1"
                     /transl_table=11
                     /translation="MKHDVSDPHALAAAYALNALDPGEQAVFESHLHECASCRQEVAEF
                     LATAARLAAAVSQPPPAAGKQAVLDAIDGVRQLPPRVPPASSATARGGTLRRRALPLAL
                     AASLAAAASLAGLAVWQVRQGEELRQRAVQAEQRLDDVSSVLAAPDARAVHGRAANGAL
                     TTVVASDMQNRAVFTAGSLPAPAAGKTYQLWLDHDGTMRPAGFISGDGTVQLSGDPADA
                     TAVGLSLEPVGGSPHPTTAPLLLMALPS"
     gene            complement(20506..21075)
                     /locus_tag="C0216_RS34405"
     CDS             complement(20506..21075)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS34405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_246042565.1"
                     /transl_table=11
                     /translation="MAPTTADAEAWAVDAHRQDRVRSIRARTRRAVPAMPDPDASLLVP
                     VLAAAALVIRTAVLEMRQPGTARRTLAFAGSPRAMAAGATVTAAVLLTGAGRGGWTAVA
                     WAVLAGALTAHLTGRDLRTSAPEASAGGGPAVTPRRIGAVAAAVGTPLAAAAAALYTLP
                     ATGLPVLAIGLALLLAGLVLAAARRR"
     gene            complement(21164..21556)
                     /locus_tag="C0216_RS15935"
                     /old_locus_tag="C0216_15910"
     CDS             complement(21164..21556)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524500.1"
                     /locus_tag="C0216_RS15935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15910"
                     /product="ACT domain-containing protein"
                     /protein_id="WP_114055928.1"
                     /transl_table=11
                     /translation="MTGEKDLRTLLASMSPQLNEGEYVFALAPQGEVPAGTRPVATVRE
                     EEGLTLVLPRADADRLGLAYDYVAAWITLRVHSALDAVGLTAAFATALASAGLSCNVVA
                     GYHHDHLFVPHGEAPRALAVLADLAG"
     gene            21699..22478
                     /locus_tag="C0216_RS15940"
                     /old_locus_tag="C0216_15915"
     CDS             21699..22478
                     /NRPS_PKS="Domain: PKS_KR (16-184). E-value: 4.2e-14.
                     Score: 44.8. Matches aSDomain:
                     nrpspksdomains_C0216_RS15940_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608143.1"
                     /locus_tag="C0216_RS15940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15915"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_114055929.1"
                     /sec_met_domain="adh_short (E-value: 1.8e-30, bitscore:
                     104.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 4e-30, bitscore:
                     104.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQRHLVELFSLDGLVAVVTGGSSGIGRAVAGALARAGAGVVIV
                     ARREAELASAVDEFAADGCRAAWVSADLGTREGVRAAAEQAAGVFGEPDILVNSAGINL
                     RPPMGELDDAVWDATMAVNLEAPYLLGQRFGPGMAERGFGRIIHISSQQAHRAFVQSGA
                     YGVSKGALESLARSQAEAWSPHGVTCNALVPGFVVTPLNARLSSDEETVAALARRTLVG
                     RNGLAEDFAGAAVFLAGRSSGYITGQAIFVDGGFSAH"
     aSDomain        21747..22250
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C0216_RS15940_PKS_KR.1"
                     /evalue="4.20E-14"
                     /label="C0216_RS15940_PKS_KR.1"
                     /locus_tag="C0216_RS15940"
                     /protein_end="184"
                     /protein_start="16"
                     /score="44.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGGSSGIGRAVAGALARAGAGVVIVARREAELASAVDEFAA
                     DGCRAAWVSADLGTREGVRAAAEQAAGVFGEPDILVNSAGINLRPPMGELDDAVWDATM
                     AVNLEAPYLLGQRFGPGMAERGFGRIIHISSQQAHRAFVQSGAYGVSKGALESLARSQA
                     EAWSP"
     CDS_motif       21753..21842
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C0216_RS15940_0001"
                     /evalue="1.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="C0216_RS15940"
                     /protein_end="48"
                     /protein_start="18"
                     /score="17.7"
                     /tool="antismash"
                     /translation="VVTGGSSGIGRAVAGALARAGAGVVIVARR"
ORIGIN
        1 ggtccccggc atcggccact gggtggttcc gcagtctccg tgcgcgcagc aggtgctcgc
       61 gtcgttcttc gcccgcccga ccgcccccga cacgtcgtgc gtggacggtc tcaagccggc
      121 cccgttcacg atcatcccga aatgaccggg agcgcagatg actctccacc gcacgccccg
      181 caggcgtacc gtacggcggc tgcaggccgc gtccgcgggc atggcggccg gcctgctcgt
      241 caccggcagc ctgctcgccg cgcccgcggc gcaggcgcgg tccggcaccg acgccagtgc
      301 gacccccggc gcgccgctcg gcacggccgc ccgcaccgtc ggcgatgcga gctacacccc
      361 gggcgcctgc ccgaagactc cggagccgat cgaggagctc gaaggggccc gctgcggaac
      421 cctcaccgtc cccgagaacc gctccgagcc ggacggcaag aagatcaagc tcggtgtcgc
      481 gatcgtgccc gcgctgtcgg ccgcgccgaa gcccgacccc atcgtgtggc tcgccggcgg
      541 ccccggggac gacgcggtcg gcgaggcgga gatggcgatc ggcggcggcc tgaaccgcga
      601 ccgggacgtg gtcctcatgt cccagcgcgg cacgtactcg gccgagccga acgtgctgtg
      661 ccccaacatc gacgagttca acgcgcgagc cgtcggcctc gtctccggcg caccgtccac
      721 cgaacgcctg cacgtcgagg ccaccaaggc ctgccgcgac cggctggcgg cccagggcac
      781 cgacctcgcc gcctacaacg acaccgagag cgccgccgac tacgaggacc tgcgggcggc
      841 gctcggcctc aagcagtgga acctgtacgg catctcctac ggcacgcacc tcgcgctggt
      901 ctacatgcgg ctgcaccccg gcgggctgcg ctccgtcgcc ctcgacggga tcctgccgcc
      961 gtccattgcg ggttccgcgg cgacctggag cagcgcccgg cagggcttcg acggcgtgtt
     1021 caaggcgtgc gcggaccagc cggcgtgcaa caagcgctac ccgaacctgt cggccacctt
     1081 cgacaggctc gtccgcgacc tcgaagcgaa tccggtcacg acgaccgtca cgctgccggg
     1141 cagcgacaag ccggtgaagg tcgtgctgga cggtggaacg ctggtcaact ggatgacctc
     1201 cgccacccac atcgcacccc aggtccccct cgccatcgac gagttggcgc acggcaagcc
     1261 gcagcggatc gccgcgcagt acgcgggcgg caagctcagc ccggcggccg tgggccgggt
     1321 cgcgcacggc ctcgtctacg gcgtgttctg cagcgagtgg acgccgtacg agacggagga
     1381 ggaggccctg gagggcggcc ggaaggcttt cccgacctac ccccgcccgg tgctggaaca
     1441 ggcgcctcag ctggccttcc tccggtcgga ctgcgacgtg tgggatgtgc ccccggccga
     1501 cccctcgatc cgggacgcca cccgcagcga cataccgacg ctcgccctgt ccggcagctt
     1561 cgacgcccag accggcgcgg acaacgggcc gtacgtcgcg cggacgctgc ccaacgccac
     1621 gatcgtcacc gtcccatacg agccgcacgt ggtgttcgcc acctcgaagt gcgcgcagca
     1681 gatcgccgtc tccttcttcg acacgccgga cgcgccggac acggcgtgcc tgaagggctt
     1741 ggaggcgccc cggttcgaga tcggggagcc cggttccacc ggatagccgg ccccggcggc
     1801 gtcagctgcc ctgcagggtc tgctgcagcc agtcgaagac gacctcgcag tgcagctgcg
     1861 gcgccatggg agagcagtgc agttgcgcgc cctcctgcgc cgtcaaccgg acgtagtcct
     1921 tgggcgaggt gagcgcgttg tacatctcgc gcggctggcc ggggtagaac tgctcgccct
     1981 cgtagtcgag gacgagggtc ggggccttga tgagggggac gacgtccgtg atcttcaggg
     2041 cctggatgcg ggtcgccggg gtgtagaagt cggtgaacag ccggccctgg cgggcttcga
     2101 gcatcgcggg gatggagaac ggctcgaagc gcttcttcat cgtcgcggcg gccgccgggg
     2161 gcagctccgg aacgacctcg ttgttccaga tgtcgttcgt ctgctgcttg tcgggtgtga
     2221 ggatccggcg gatctcggga gggaagccca gccaggggtc gacgcagccc ggcattgcca
     2281 ccagggcggc gatccggctt tcgaacgcgg cggcgcgggg cgcgaggtcg cccgccatgc
     2341 tgaggcccgt caacgcgatc cggtccgggt ccacgtcgga gcgggccgtc agccagtcga
     2401 cgagcggggt gacgaccttc tcccaggtgg gcgtgaagac gatcctgtcg acgaacagca
     2461 gccggccctg ccccggcccg tcatagacga gggcgttcca gccgcgttcg agggcggcgg
     2521 ggaccccgta cgtccacatg tcgacgttct ggccgtcgct gccgttggtc aggatcacgg
     2581 tggggcgccg ggcgccggac gtgtcggggc ggaagaacca caccggcagc ggtgtcgtcc
     2641 cgtacgggac ctgcgccttg accggggcgg gctcgcacag gtcgcagaag gcgtcccagg
     2701 ccttgcgccc cgaccggtac agctgctcct cgctgcccgg ggcgtcggag ccgaggacga
     2761 agaacagtgc ctgcccgtag tactgggcgg cgcgcagggc gcggaaccgc ttggtctggt
     2821 cgtcggcggg ggcgccgggc ggcggccgca ggagccggtc gccgagcttg cggaacgtct
     2881 ccacgtacgt ctggggggac agtccggcag cgttgacggt gttgacggcg gtcaggacct
     2941 cgccgacctc ggcggcgccg gcaccggagg cgcccagtgc caggagtgcg ctgaagttgt
     3001 acgcgggatc ctggaacagc gtcatcgcgc ccggggtgat cccgcccgcg ccggcggtcg
     3061 gcgaggcgga gccggcagcg gtgggggtgg gtgccggtgc gccgggagcg gccccgcggg
     3121 cacagcccgc catgagcgct gcgccgacgc cggcagtcgc ggtgagcagg gcgcggcggg
     3181 tggggtcggt gggacgctcg cccggtgtgt gcttcatgcc gtcggaacct agcggcggtc
     3241 ccgcgccgcg gcatccgctc ggccgcccgc aggcgggccc gcggcgccgg agtctgctgc
     3301 ggacggcgtg cgtatcgcca ggtcgccggc gtgcggcaca ccggtcggcc gcagcctcgg
     3361 agccggggcg gtcgcactgg gccgaccggc ggcagcaggg cgccgcggcc acccgcctgc
     3421 gggggttgcc cctacgccgg ggggcgtgct gcccccatgg tccggctgat cttgaacggg
     3481 caggctggag cacgcccgaa ccccgagtga aggaagtctc tgtgctctct ctgcattcgg
     3541 tgcgccgccg cgtggcgcgc accacggtcg tcggaacgct cgtcgccgcc gcatgcgcca
     3601 ccttgctggc cggcagcgcc ggggccatcg tcaacggatc cgacgccggc gaacactacc
     3661 cgttcatggc gacgattccg gagtcggctc cgaagtacgg cctgcacgac gggaactgcg
     3721 gggcgtcgct gatcgatccg cggtgggtgc tgacggcggc ccactgcgtg cagggtgacg
     3781 ggctggagct ggagggcacc gtccggatcg gcagcaggca ccgcaagtcc ggcgggaccg
     3841 tacgggccat cgaccggatc gtggtccacc ccggctacgc caacggtgag ggcaaggcct
     3901 tcaacaagca cgacatcgcg ctggtccgcc tcgaccgccc ggtggccggg aagccggtcc
     3961 gcctcgcgga gggggccggc cgccccggta ccccgacccg gatcctgggc ttcgggacca
     4021 ccgtggacac ggagctgcgg ttcgcggagc gactgcagga gttggacacc cgcatcggcg
     4081 ccgaggcgga atgcgccccc ggttacgcgg accggacgcg gctgtgcacc atcagcaggg
     4141 tgcccgaggc gatggcgtgc ttcggcgact ccggcggacc gcagctccag cggggcaggc
     4201 acgggcggtg ggagctggtc ggcgtgacct cgggtcccgg tgccccgggg gtcgcctgtt
     4261 cggacgggcc cggcctctac gccggcgtac ccgtctaccg ggactggatc cggaagaccg
     4321 tccggcgcga tgcctgacct tgcgctccgc cggtcggcag ccgggggcct caccggcggc
     4381 ggcagacggg gcggacgtcg cccgccggtc ttccctccgg cgggcctcgg cggacttcga
     4441 caaggcgctc gcgtgcaacg tcgacctctg ctcgcgtgca acgtcgacct ctgctggacg
     4501 gcccggccgc gcgggagtcg tccgtgccgg cccggctgct gcggccggcc ggccggccgg
     4561 ctcgtcccgg tatacggggc tcccgggggc cgggccccgc cgccgatggc ggagtcggtg
     4621 cgcgcggccc tgcacggggc ggcttccgta ccgctgcgtc cgtccgccgg cgccgcggca
     4681 ccgcgctgct ggtaatcagc gcggacgttg cccattgcgg acaggagttg gcctagatcc
     4741 cgcttagtgt cgtccgcaga ggtgagacgg cggccgagga gggcgacgtg acgattctgg
     4801 tgaccggtgc gacagggact ctggggcgcc tggtggtcga gaggttgcgg cagggcggcg
     4861 agagggtccg cgcgctcacg cgtacgccgg ccgcggcggg tctgcccgac ggcgtcgagg
     4921 tggtgggcgg cgacctcacc cggccgcaga ccctggcggg cgcgttcgac ggggtgcgcg
     4981 ccgtgcacct gctcggcgcg accggacacg accacacccc gctggagacg ggcccgcagg
     5041 tcgtggccat ggcggccgag gccggagtgg agcggctcac cgtgctgtcc gcaggcgagg
     5101 acgggccgtg ggaagggacc gtgcgggcga gcggcctgga gtggacgttc gtctggccga
     5161 tcgacttcat ggccaacacg ctcggctggg ccggggccat ccgcacagcg gccgaggtac
     5221 gcgagccgta cgcgggccgc aggaccgcct ccgtggacga ggcggacgtc gccgacgtca
     5281 tcgccgccgt gctcacgcgc gggggccacg cgggccggcg gttcaccgtt tccgggcccg
     5341 aagcgctcac cccggccgac aaggtgtccg ccatcgcggc ggccaccaac cgggctctcc
     5401 gcttcaccgg gctgaccgac gagcaggcgc gccggcagtg gagggcggag ggctggcccg
     5461 aggagggcat cgcattcgtg ctgcacatgt gggccaccgt ccccgacacg gtggccgagg
     5521 tgacgacggc ggtcgaggag gtgctgggcc gcccgccccg cacgttcgcc cggtgggcct
     5581 ccgcgcacgc cgccgccttc cgcccctgac cggggcggct cgtcacccgt cctgcggccg
     5641 gccggcctcc aggcggcgga ggatcgcctc ggcgagccgc cacaggtccg agtcgcgccg
     5701 gaaccggcgg tcccgctgcg ccctgacggc gtcggcgagg cgcctggcct gcgcctcatc
     5761 gaggtcgtcg gccatgtggg cggcgagcag cagcgcctgg tgctgctcca gtgggctgcg
     5821 cgggtcctcg acggcggtga ccgcggcgtc gacgtcgcgc agggcgcggt cggcctgcat
     5881 cgcggcgagc gcggtgatgc gctcctcggc ggtcccctcc cggaaccggc tcaggacgtc
     5941 ggccggttcg tgctcgcgct cctccgcgga gcggcggtcc cgggaagcgg cctcctccgt
     6001 ggcccaggtg cggggcacac cgcggtgcgc ggtcctgcgt accggcgtgc ggtcggcggc
     6061 agcgggagct gcgctgtcca gcaggacctg cgcctcggcg cggagccgcc gcgccgaggc
     6121 gacgtcgccc tgccgctcgg actcctcggc cagcgccagc ctgtccgcgg cggccgcgcg
     6181 gagccggagg ctgactccgc cgacctccag gccttcgagg cggctgccga acagggcgag
     6241 gagcagcagg actccgccga agacgagcag gacggccgtg ccggtgccgt tctccgtcac
     6301 gaacacggcg aggacgcccg tcccgaacgc cgccgcgccg agcagcccgg cgaccaggcg
     6361 cagggcgggc gtgaagtgga agggtgcagg gtcggaatcg gccggctcgc cccttctccc
     6421 cggcgacgtc aggacggctc ctcgcccgtg tcctgggggg cttgggcgcg cttggccacg
     6481 accgcggctg ccgcggcggc gctcgccgcg aaggccaggg cgagcatcca ccgctggtcg
     6541 aaggtgtggc cggtggcgtg gtcgagggag aggcggcccg ggccggcgag gccgatggcg
     6601 gccgctgtga agccgaggaa cgccgggtac tcgtacccgc cggcctgggc gaagaacccg
     6661 gccggggcgt ggacggacac cgctccggcc atggcgcccg cggcggccgc gcccgctgcc
     6721 ggggtggcga ggccgaggac cagcagggcc ccgccgccgg cctcgccaag cccggcggcg
     6781 agggcgctgc gccgtccggg ggtgaagccc atgtgctcca tggcggcggc ggtccggtcg
     6841 aggccgccgc cgccgaacca gccgaagagc ttctgtgtgc cgtgcgccat cagcacggct
     6901 ccggtcccgg cgcggagggc cagcagagcg aggtcgcgtc ggttgatcca tgtcatcgga
     6961 agtctccctg ggacggcggg gcacggtgcc ggagacatcc ctatccccgc acgccggcgc
     7021 cgccccgcgc cccgggccac gtccgcccgg acgggtgccg gtggcacgga gccgccgaac
     7081 ggaagccggc cgccgtccgg cgcggcttct tcgacggcct cggcgcccgc ccggcgccgg
     7141 taccctcctg gctttccggc gcgcgggcgg gcccggtggc gggcctcagc cgagggtggc
     7201 cgcgaggtcg ctgcacgcct cggcgcacga gcggcaggcc tcggcgcaga ggcggcagtg
     7261 ctcgtgctgg tcggcgtggg cggcgcactc gtcggcgcag gcccggcagg cgacggcgca
     7321 ggccgtgacg agggcgcggg cgatgtcggg gttgtagccg gtgtgccggg agaggaccgc
     7381 ggccgtggcg gtgcagatgt cggcgcagtc catgtcggtg cggatgcact tggtgaggtc
     7441 gccgaccatg ccttcggcca gacaggcgtc ggcgcaggcc gtacaggcct gcgcgcaggc
     7501 gatgcattcc tcgatgcagc gggcgagcct gtcctggtcg aggtcgccga ggtcggcggg
     7561 gtagctgtgc agcatgtcct tgacgggcgc gttcatggcg agggccctcg ctttcccgcc
     7621 gccggccgga gggagccgcg ccttcggggg aaccgtgcgg cggcttaccg ccaggatcgc
     7681 cccgcggccc ggtttccgcc cggcgggcgg ggtgtcattc ggggcggctg aagcggtggg
     7741 ccgcccagag cagggccgcc gcgccggccg ccaggaggac gcccgcttcg aggagcagcg
     7801 gcggctgccg gccgaaccag tcgatgccgc cgacggcggc ttggtcgggg acccgcaggg
     7861 cgatgcagcc gcggagcagg tcgacgccgt aggcgagcgg gttggcgtcg gccagggcgc
     7921 gggcccagcc gggcaggttc tgcagcggga agaagccgcc ggagaggaac atcagcggca
     7981 tcatgaccag gccgagcagc atgtggaaca cctcgggccg gtgcaggctc accgcgaggg
     8041 ccagggacag ggccgtgatg gtgaaggagg cgaggaccat gccgccgagg agcagggcca
     8101 tgaggaccgg atcgtagggc aggccgacgg cgccggcgag acagaggagg agggcgccct
     8161 ggaccgtggc gaccagggtg ccgccggcgc agcttcccag gagcagggtg gaccggcgca
     8221 ccggggccat cagcagctcg cgcaggtagc cgctctgccg gtcggtgatc agccgcacgc
     8281 cgaccatgat ggcgggcgcc tgcacggtca tcatcagcat gccggggaag aggtaggcct
     8341 ggtatccggt gccgagcgag gagtccggga tgagggcggc gagtccgcct ccgaggatga
     8401 agaggtagag caccggctgg aacagcacca gggcggcgtg ggtgggctgg gccgccaggc
     8461 gcagcaggtc gcggtggacc agggcgtgca cggcgcgcag ttcgcggcgc agccggtccg
     8521 gcggcgcggc cccggggccg cgggtgccgt cgggggcggc cggtgtgcgg agggcgggtg
     8581 tggtcacggg gcgctcccgg gggcgtccgg cgtcaggtcg ggccgggcgg cgttgatgct
     8641 gcggccggtg tggtggaaga agacgtcgtc gagggtgggc ggtgccgcgg acgcggcgtg
     8701 cacggagatg ccgcggcccg ccagggcggc gcacaggcgg gggatccagg cgctgccgtc
     8761 gggcacgcgc agccagaccc cctcggcgtc cgcggtgacg gcgggatccg gcgatccggt
     8821 cgcctcgcac acgatcctgc gggcggtcgc gtcgtcgctg gtgcgcagca cgacgcggtc
     8881 gtcgccgatc gctgccttga gtgcggcggg cgcgccctgg gcgaccaggc ggccgccgtc
     8941 gatgatggcg aggcggtcgc agtgctcgga ctcttccagg tagtgggtgg tgacgaagag
     9001 ggtgctgccc tgccggtcgc ggagggcgcg caggtgctgc cagacctgtg cgcgggcgtg
     9061 ggggtcgagg ccggtcgtcg gctcgtcgag gaacaggacc tcgggtgcgt gcagcaggcc
     9121 gcgggcgagt tccaggcggc gccgcatgcc gccggacagg gtacgcacca gggcccggcg
     9181 ccggtctgcc aggtcgaccg cctccagtgt ctcggcggtc cggcggcggg cgtcgcggcg
     9241 gctgagcccg aagaggcggg cgtggatgtg caggttctgc tcggccgtca ggtcggggtc
     9301 gagggcgctg tgctggaaga gcattcccac ccgccggcgt acccggtcgg gctcggtgag
     9361 gatgtcggcg ccggccacgg tggcccgtcc cgaggtgggg cgggcgaggg cgcacagcag
     9421 ggcgatggtg gtggacttcc cggcgccgtt ggggccgagg aaggcgaagg tctcgccccg
     9481 gtgcacgtcc aggtccaggc cgcgcagggc ccgggtggcg gtgccgtcgg gtccggggta
     9541 cgtcttgacc aggccgcggg tgctgatggc gtatgccgtt ccggctgcgt cgtgcgcgct
     9601 gtccgggctt gtgcgggggg cgggcgcggg ggctgcctgg gcgggggcgc cggcaccggc
     9661 gtgtggctgc atggggtcgg gtcctcgtct acgggtggtc gtccgccggg acgggcttcc
     9721 gggagcggtg gcgcccccgg aggggcacca ccgcttcggc cggcggccgt gctgggacgg
     9781 ccgccggccg gaagggccgg gtcaggcgca gctgacgccg acgcagacgg tgttgagcag
     9841 ggtgagcagg ccgacgcact ggcaggtgtc ggcgaacgcc gcgccgtcgg cgccgagcgg
     9901 gtcggtctcc ggaagggcgt gcaggtgggc gagcagctcg aagtcgcggt tctccatgac
     9961 gttctccttc tctgtgactc aagcggcagt gttctgccgc tcagaccggc tgctggacca
    10021 tccagtgccg gggttctgtg tggcggaccc gcaggaggaa tgccaggatt cccgcggttc
    10081 cgtcgctcca gctcgtcgag gcctccccgt actcgttggg gaagacgacg tggctgccgc
    10141 gccgggcccg ttcggcgacg aggagacggg ccaggtcgtc ggccatcgcc cggtaggagg
    10201 actcccccgt ggcgtcggcc aggtcgagga ggaagtcgcc gttgccggcg aggccgtggc
    10261 attgcgtcag gggggcgcgg gaggcacgct ggacgacggc gcgggccgct ccgtgggcga
    10321 ggttgcggaa ccggtcgtcc ccggtcgcct gccacagcct gaccaggaag gatccgatgc
    10381 cggccgagcc gtggcaccag tacggtgccg tgggcaggtc cgcggtgtgg gcgggccagt
    10441 ggaccgcgtc gccgacccgc acggcgcagg ccgcgaggtg ttcgcccgcc gccagggcga
    10501 gatccctgtg ctgttggcgt tctgtgacgg cggcggcggc gaggaggaag caggcgatgc
    10561 ctgcggtgcc gtgggcgaag cccaggtagc gtttcccggc ttcggcggag acggcttccg
    10621 cggggaccgg ccagctcacc gcggccggct cgcgccgtgc ggcggcggcc agccggtcgg
    10681 ccgcgtcggt gacgagcccg gcgaggcggg ggtcccgggt gcgataccac aggtgggcgg
    10741 cggcgagtcc gctgcctgcc gtgccgtggg tgatgtcgtg gctgggcgtc ggatcctgcg
    10801 gggccagggc cagggccagg gcgtggtcca tgagggcgct gtcgttgacg gcgcggccgg
    10861 cctcgtacag ggcccaggcg gtgccgcggc cgccgaagtg caggccgggg cgggtcgagc
    10921 gggtgtcggt ccgggccgcc gtccaccggc ccgcggtgga tatcagcccg gggagccgcg
    10981 ggtcgccggt gagttcgaag tagcgggtca ggacggcgag gactccggcc gcgccctgct
    11041 ggacggtgca ggggtcggcc tcgccggcca tcgtggagac gggccacagc cgccggtcgt
    11101 ccgccgggtc catcgtgtcg acgaggtggt cgaccatgcc ggcgatggcg gcgtccacct
    11161 cgtcggcggc cgtgccgccc ggctggggtg cggcggcggg gcgtgcgggt cgcatcaggg
    11221 cggtcgcgcg gagggcggtg agcgccctgg cggggtccca gcgctcggcg gggtcgtcct
    11281 tcatcagccc gaggacggtc tcctggaggg ccggcggcag gtcgagcggt gcggtgcagg
    11341 cggtgagcca ggcggcgagc cgctgctcgg cgggccggcc ggcgggttcc tcggggagca
    11401 ggttcgggac cttcccggcc aggacgaagc agatggtggc gccgaggctg tagtagtcgg
    11461 ccgtcgggga gaccggggcg tcggccaggc gttcgggggc gctgaagccg ggggtgccga
    11521 ctcgggtcgg cagggcgccg tcttcgcgga ggacggcgag ttcgaggtcg atgaggcgga
    11581 gttcgccgtc cgggcggacc atgacgttgc cgggggtgaa gtcccggagg acgcagccgc
    11641 gggcgtgggc cgccgcgacc agctccgcga ggcgtacggc ctgggcgagc gcgtcggcgc
    11701 ggtactgctc gctgccggag tcgcggaagt gctccgcgac ccaggtgcgc aggggtatgc
    11761 ccggcacctc ctcctgggca aggaacaggt gcccgccgac ctcgaacatc gcgagcggct
    11821 ccggtgcgag gcccgttcct ctgagcttct ccagcgtccg tgcctcggcc cggagccagt
    11881 cgcggacgtc ggatccggac gcgtcggcct cgacgtgcgg ccgggtctcc ttgatcacca
    11941 cgggtgcgcc cgtggtgacg tccgtccccc ggtagacgcc gcccttgttg gtgtgccgga
    12001 tcgcctcccg tacggagaag cggccgccga ggagcaccgg gctggcggcc gtctgctcgg
    12061 tgcgcggcgg ggcggggacg gacggcggga aggggctgac ggcccagggg ggcgggtcgt
    12121 actggcctgt gcgcttgtct tcgacggggt tgccgtcggg gtcctcgatg taccacacca
    12181 gcaggccctc gtccgacagc cgccgccggc cgacgaaggc gccgtaccgg tagtggacca
    12241 ggctgtgcgc ggcgtagggc tggtcggaca ggatgcgcgg gccggcgagt cccgccgtgg
    12301 cccggtgcag ctgctgcgct attcgggccg cgtcggcgtc ggaggacggg tagacggtga
    12361 ggaacttgcc cgacgaaccg cgcggcgtgg cgcgggtgtt gagcgcgctg acctgctcca
    12421 gcgaccgggc gaacttgaac gccgactcct cgcgcagcag cacgtccagg gaccgggcga
    12481 gaacctccgg cgcggaggcg gcggttgccg acacgtggag cttccagccc tgggtgcggg
    12541 gggtcgcgga accgggcgtg aggcggcacc acatgtcgtc cgcgtcgacc gcccaacgcg
    12601 tttcggtgtc cgtggccttg agtgcgtcgt ggagaaggct ttcgagatcg gcttcggttg
    12661 cgtggctcgt catgcgtgtc cctctcaacg gtggaaaccg ctggtggaat gtgccgtcgg
    12721 tttatgaacg tacagtccgc accgcgccgt ccgtcagtgg ccgaagggag cgcacggagt
    12781 tgttgcggcg ccgaatggcg tctaccggcg cgcgggcagg cgcgtttggc tctggaggtc
    12841 ggggaggctc cttggtgcgc ctcgcgggat cgcgacggag cggcgcacgc acctgaattc
    12901 aggggcggag cggcagcgga attcgtcggt gcgattcccg ctgcggtcgg ttccgtggga
    12961 gaacgtctgc cgcggaagca gggccgacgc tccatcgggt ccggcttccg gcgtacagct
    13021 ttgccgctgc ccggcccgcg gtaaagactg tgtttgcgcc gtcgcggcaa cctgcggcgg
    13081 agcatgatcc ggtccggcgg ccggacggcg atcatgcgtc tgaactgggc gcggccgccg
    13141 cgtcacacgc gtcacaaccc cccggcacat gcaggggatt gactcaaaac gacaaccgga
    13201 atgctttcgg tcgacttgga ggcgaaaacc cgacagcgcc ggcatccgtg cttcgggaat
    13261 actgcaccgc ctttccgaac tcctgtttcc ctgcgctttg ggtgcaggca accggggtgc
    13321 ggggagggcg gtggtgagcg tgcattctcc gcaccgtgcc gaccggttgc ccggccgtac
    13381 ggaaaggcag attcgggcgg tgcgcagcct cgccccgacg ggcgcgtgca cgggcggggt
    13441 cacgcgggct tcctgcccgg ggtggccgag tcctcctggc agcgccccgt cgtgcggcgc
    13501 cgggtgcgct cccgccgcgg cacccggcgg accgcgtccg ggcccggacc gcatccgcgg
    13561 atcgggcccg gacggaagag gagagtgggg gcgacaggac aggaggcgct gtgggacgtg
    13621 aaccggaggc cccgttctgg gcgcctgccc ccgacggggg ccgcgtggag cagcccgtct
    13681 gctcccacct cggggaggcg gtgctccgtc ccgtccgcca cgtggggaag gggtgcgagg
    13741 actgcgaggc cgggacgccg cgggtaggcc tgctgcggtg tctcacgtgc ggccatgtcg
    13801 gctgctgtga cagctccccg gggcagcacg cccatgccca cgccgaggcg tccgcgcacc
    13861 ccctcgccca gtcctgcgcg agcggtgccc ggtgggcctg gtgctatccg gacggcctgt
    13921 acctcgtccc ggccgccccg gcgccgcgct gagcacggcc ctgtacgggg gcagccggcc
    13981 ggtgggcggg ggcgtcgtca gccccagagg cgggcggcga agaacgccgc gaccatggcg
    14041 gcgccgagga cgacgagcgc gaggaagacg ccggggtgtt cccaggggcc tccgtccgcg
    14101 cgttcccggt gggccgatgc ggtggatcct tcggccggag gagtctcccc cggcggaatc
    14161 ctgaggttcg acatgatccc tcctcggagc gggtggtggg cggtggggcg gttcaggggg
    14221 ccgggcgggc tccggacgcc agggcggtgc cgtgagcggt gtcgcgggag ccgccggggc
    14281 gagcagtcgg tcgagcaggg ccgacaccgc ggcgtccggg tctgcgggcc ggggcagcgg
    14341 cggtgggctc ccctcgacgg cgcgggcggc gaaccccgtg tccaggtggg ggaatctggc
    14401 gtcgacgacg gcgacacgcc gcttgcgcac ctcgcgggcg aggacgccga gccagccggc
    14461 gagcgcggct ttggaggccg cgtagtcggc cgtaccggcc aggggggtgt cgacgacggc
    14521 gccggtcacc gcggcgagga agccgccgtc gccgaccacg ggggcggcgc cccgcaggac
    14581 agccatggga cagagggcgt tcacggtgag caggtgttcg gcggcggcgt ccgacacgcg
    14641 cgctgccggc ccgaaggcgg cgacgccgac ggtcaccagg acgccgtcca ggccgccgag
    14701 ggcctcggcc gcccacggag ccagaccgga gcagccgcgc aggtcgtagg cgtcgatacg
    14761 gcgggccggg ctgccggttc cggcggccag ggccgccagg cggcggcggt cgcggccggc
    14821 cagcgcggtc cggcagtgcc tcccggccag cccgcggacg gcgagggtgc cgatctcgcc
    14881 ggtggcgccg accaccagca ccctcgcgcc gccgccgggc acgttcacct cctcggcagc
    14941 tcggcgggcc ggccggccgc cgggccgagc cgcgggcggc ccgccgtctc gcgggcggcc
    15001 tggtcggggt ggcggcgccg ccagtacggg ttgtcgtgcg gcaggccgcc gctgacccgg
    15061 ccgtacatgc cgaacgtcat gatcagcagg cccatcagga agctgaagaa gacgttggag
    15121 aggccgaagt ccaaaatgtt gccgggtcgc ccgatgagga acaggtgcac gaacccgctc
    15181 aggaggaaca gcacgccgac cgcgatgttg acggacgagg cgacgttgcc gccgatcagg
    15241 gcggcgacga ccaggagcag tccgaacacg accgagacgg tgctcagcag tccgttcgtg
    15301 gacaggccgg cgatctgctg cccgtcggtg tcgaaggcgg agaggctgtc ggcgtagccg
    15361 aggcagccga agaggaggag cagcaggccg cacagggcgg ctccgatccg gtagaccctg
    15421 ttcagggggt ggtcgaccgg aagttcgtca cgcaggctca tgggtcctcc cgtggatggc
    15481 tgcatacagg ccccgaggtc tccaggctgg ggcgcggctg ccggtacgga aagtcgcagt
    15541 gattctgcac cgttttgcct gactcctccg cacatgccgg ggatgtgcgg taccgctcag
    15601 gcggcgggcg gacgggcagc ggcgtgcacg gcccggtgga cggcgcgggc caggcgcgcg
    15661 ccccacaggg agcgggggcc ggcaaagggg tgggcgtcct cgcccccgcg ggggacgcgg
    15721 gcggcgacgc acacggcgtc cgtcggggtg cccgagcagt cgtatccggc gtccagcagc
    15781 gcctgcacct tggcttcggt ggcggttgcc accgcgttga ccagcgcggc atcggtcagg
    15841 gccacgggaa gcgccaccac gatgttgacc gtgcccggct gcggcgccgc ggcggcgccc
    15901 tgcccgggag cggccgccca gccccgcact ccgagccccg cggtggccac cgcctccgct
    15961 cccgcgtcgt gcgcgtggcc gtacgcgcgg acgtcggcgg ctgtcatcag gccgacgcca
    16021 ggcccgcgca cgcccgcgtc ccgggcgagc tccgcgaggt ggcgttccgg atcggtgcgc
    16081 cggtagccgt gcgacacctg ggcgttgagg acccaggccc gttccccgat gccgccgccg
    16141 aggacggcgc tgctgatcat ccgccagtcc gcaccggccc gccacagaag gccgtgcagc
    16201 cgctcgccgc cctccaggcg gtcgagcggc tgcacgggca gcaggccggt tgcggggcgg
    16261 ggcggcggaa tgactgcgga caccgggcgg gaactccttg cggggcgggg accggctgat
    16321 cgtacgccgc ggcagccgcc cgcgcggagg ggaggggagg ccggggcggt gcagggcctg
    16381 cccccgtccc gtggcggggg caggtaccgc cgaccgctac ttcggcatca ggacggtgtc
    16441 gatgatgtag acgttggcgt tcgccgtctt gacgttgccg cacaccaccg ccgccgtgtc
    16501 gttgaccttg taggactcgc ccgagccctt ggtcgtgacc gtgcccttct ggagggtctc
    16561 gaaggagccg ttctcgagct gctgcggcgt cagcctctgc ccgacgacgt ggtaggtgag
    16621 gatgttcgtc agggccgcct tgtcggcgag gaccttgtcg aggtcggcct tcgggatctt
    16681 ggcgaaggct tcgttggtgg gcgcgaagac ggtgatgtcc ttcgcgttgt tcagggtgtc
    16741 gacgaggccg gcctgcttca ccgcggcgac gagggtggag agggccgggt tgttggaggc
    16801 cgcggtggcg accgggtcct gggccatgcc ctcgaaggag ccggcgcctt cctcgggcac
    16861 gctcgcgcag cccgggccga acggcttgcc gcccgttgcc gcgtcgtcca tcggggcgct
    16921 cccggcggtc tgcgctgccc cctcggctcc cgcggtgggg gcggccttgg tctcgctgcc
    16981 ggagtcggag cacgcggcga gggagaaggg caggacggct gcggccgcaa cggcgactgc
    17041 ggtacggcgg atgcggatgg tgttcatggt gggtctactc cttcaacgag ggttgtacgg
    17101 ctgttcggtt gtccggtggc cggggtggtg ctccggccgg cccgcgagca ggccggccgg
    17161 tggtctgggg gacggtgacg aagacgctgt gccggccgct cgccccgtcg gggacggtgc
    17221 gggtgcgctc ttcggtctgc acccgtccgg tgccgtccgt ggcgcggacg gtgagggtgt
    17281 gtccgccggg agcggcctcc cagcggtagg tccactgccg ccaggtgtcc gcgcccgtcg
    17341 gagccgcgag gtcggcgtcc tgccagggcc cgtcgtcgat gcggacctcg acccggatga
    17401 tgcctctgcg ctgggcccag gcgacgcccg cgacggtgac cggcccggcg gcgggccgcg
    17461 cgaagggctt gggggtgtcg atgcgggact gggtcttgac cggcgcccgc cgggcccagc
    17521 cgcgccggac ccagtagggg tcgtaggcgt cgaaggaggt cagctccatg tcggtgatcc
    17581 acttgcaggc ggagacgtag ccgtagaggc cgggcacgag catccgcgcg gggaagccgt
    17641 ggtcgaaggg gagcggttcg ccgttcatgc cgacggcgag catggcgtcc cgcccgtcca
    17701 tcagctcctc gaccggggaa ccgagggtca tgccgtccgc ggagcgcgcc accagctggt
    17761 cggacctgcc gccctgggac ggcggccgca cgccggcctc ccgcaggagg tcggcgaggg
    17821 ggacgccgag ccagcgggcg gtgccggtgt acggaccgcc gacctcgttg gagacgcagg
    17881 tgagggtgat gtcgcgctcg acgagggggc gggccaggag ctcgccgagg gtgagggtgc
    17941 gggggcgtgt gacgccctcg ccgtggatcc gcaggcgcca ggttccggcg tcgatcctcg
    18001 gcacggcgag cgcggtgtcg acgcggtaga agtcgcgggt gggtgtggtg aacgggctga
    18061 tgccgggcac cttcagttgt gcgccggccg ggagggccgg ggccggggag gccggcggcg
    18121 gcaggaccag ggcgttccgg gaggcggcgg catcctgccc gtgccggtcg gcgagggtgc
    18181 ggcccagggc tccggcggag gcggcggcgc cggcggtggc agccgccgcg gtgaggaagc
    18241 cccgcctgtt ccagtcgccc cggccgctcc cggccggccc gtccggcggg gcgcctgccc
    18301 tccgcgcgac caggaagcag agggtggccg cccctgccgc cgcgccggcg agcgagggaa
    18361 gcgcgtcgcc gaggccggcg gcgtcgggac ggctcagcgc ggcggcggcg ccgacggctc
    18421 cgaagagcag gacgccggcc gccccggcac gcaggtgacg caggctcagt acgccgaggc
    18481 cggcggcgct gagcgccagc aggaagagga tgccgagccg gagggcgtcc ttgtcgtcct
    18541 ccccgaaggt gcggaccgcg aagtccttca ccgcggccgg ggccaggtca accaccgcgc
    18601 cgcccacgac cgtcaccggg cccgcggccg ggcgggccag gccggctgcc agctcggccg
    18661 cggcgagcgc cgcgaacgcg gccaggagtc cggccagggc gccggggccg acgcgggcga
    18721 gggtgttgcg gaagctgctc acgtacggga ttcggcggca cgcgcccggc ggattggccg
    18781 gacacccgaa cgagtgaaat atcgcgcctg tggcgcccgg cacttgacat caacccggcg
    18841 gcccgtccaa ctcgtcggcc ggagcggctc ccctcttccc tgctcccttc acccgaccgg
    18901 gctgtccgaa cgcggcgaag gcggcggagt gccctcccat ccgcagcgcc gtccgctacg
    18961 aagaacaccc gacacaccac acgttccggc gccgggctcc gccccgccac ccggcagggg
    19021 cggccccgca ccacgacgag gacaaggacc ggcatgcgat ggacacccct cccccgggca
    19081 acccgccccg gcggcccctc cccctcctca cccgtgccgg agcccggccg gtgaaccaac
    19141 cgctcccctc cggcgcaggc cacgccccgg gcggggccga cctcgccgag ctcatgcagc
    19201 aggtcgcccg aggcgacaag cagtccttct ccgcgctcta cgacgccctc gcacccctgg
    19261 tccacgggat cgtcgtcaga gtcgtacgcg accgcgcgca gtcggaggag gtcgcccagg
    19321 aggtcatgat cgacctgtgg cggcaggccg cccgctaccg gcccgacacc ggaagcgtca
    19381 ccacctgggc ggcgaccatc gcacaccgcc gcgcggtcga ccgcgtccgc tccgcccagg
    19441 cggctgcgga ccgcgagcac acccaggccg cccgggagca ccagaccgcc ttcgacgagg
    19501 tcgccgagca ggtggagacc cggctggaga gcgagcaggt acgccgctgc ctgcgcgggc
    19561 tgaccgagct ccagcgccag gccgtggacc tggcctacta ccggggactg acctaccgtg
    19621 aagtcgccga agccctgcgc acaccgcttc ccaccatcaa gacacgcatg cgcgacgggc
    19681 tcatccggct ccgcgactgc atgggggtga ccacatgaaa cacgacgtat ccgatcccca
    19741 cgcccttgcc gccgcctacg cgctgaacgc cctcgacccc ggcgaacagg cggtgttcga
    19801 gagccacctg cacgagtgcg cgtcgtgccg gcaggaggtc gcggagttcc tggccaccgc
    19861 ggcgcgcctg gccgcggccg tctcccagcc gccgcctgcg gcgggcaagc aggcggtcct
    19921 ggacgcgatc gacggtgtgc ggcagctgcc gccgcgggtg cccccggcct cgtccgcgac
    19981 cgcccgcggc ggcaccctgc gccgcagggc cctcccgctc gccctggccg ccagcctggc
    20041 cgccgccgcg tcactcgccg gcctggccgt gtggcaggtc cggcagggcg aggagctgcg
    20101 gcagcgggcc gtacaggccg agcagcgcct ggacgacgtc agctccgtcc tcgcggcgcc
    20161 cgacgcccgg gccgtgcacg gccgggccgc caacggcgcc ctgaccacgg tggtggcctc
    20221 cgacatgcag aaccgggccg tcttcaccgc cggcagcctt ccggcgcccg ccgccggcaa
    20281 gacgtaccag ctgtggctcg accacgacgg caccatgcgc cccgccggtt tcatctccgg
    20341 ggacgggacc gtgcagctca gcggcgatcc ggccgacgcg accgcggtcg gcctcagcct
    20401 cgaacccgtc ggcggatcgc cccacccgac caccgcgccc ctgctgctga tggccctgcc
    20461 ttcctgaccc cggcgggcgc cggccgcagt gcgcgccggg agccttcagc ggcgccgggc
    20521 cgcggccagg accaggccgg cgagcagcag cgccaggccg atggcgagga cgggaaggcc
    20581 ggtggcgggg agggtgtaca gggccgccgc ggccgcggcg agcggtgtgc cgaccgcggc
    20641 ggcgaccgcg ccgatccggc gcggtgtcac ggccggaccg ccgcccgcgg acgcctcggg
    20701 ggcggaggtc cgcaggtcgc ggccggtgag gtgggcggtg agggcgccgg ccagcacggc
    20761 ccaggcgacg gcagtccagc cgccccggcc ggcgccggtg agcaggacgg ccgcggtgac
    20821 ggtcgccccg gccgccatgg cccgggggct gccggcgaag gccaaggtgc ggcgggcggt
    20881 tcccggctgc cgcatttcca gcaccgcggt acggatcacc agggcggcgg cggcgagcac
    20941 cgggacgagg agggaggcgt cgggatcggg catcgcgggg accgctctcc tcgtgcgggc
    21001 ccggatgctg cggacccggt cctgccggtg ggcgtcgacc gcccacgcct cggcgtcggc
    21061 ggtggtgggg gccaccgggc ggcggcccct acgtgtgcac cagtgtcgcc ggaatcgggc
    21121 gtcccggcag gccccgtacg gatacccggc ggcgccgggc ccgtcagccg gcgaggtccg
    21181 ccaggacggc cagggcccgg ggtgcctcgc cgtgcggcac gaacaggtgg tcgtggtggt
    21241 agccggccac gacgttgcag ctcaggcccg ccgaggccaa ggccgtcgcg aaggcggcgg
    21301 tcagacccac cgcgtccagg gcggagtgca cgcgcagggt gatccacgcg gcgacgtagt
    21361 cgtacgcgag ccccagccgg tcggcgtccg cgcggggcag caccagggtc agcccctcct
    21421 cttcgcggac cgtggccacc gggcgggtcc ccgccggcac ctcgccttgc ggggcgagcg
    21481 cgaacacgta ctccccctcg ttgagctgcg ggctcatcga ggcaagcagg gtgcggaggt
    21541 ccttctctcc tgtcatgtcg cctcctcggg cgttgccgtg gcggggtggt ccggctcggg
    21601 ccggcaggtg ggcgtggtgc gggaccggcc gctcgcggtc gtgccgcgcc acggctgagc
    21661 ggtgcccggc tgcggcaggc tcctcgtatc ctgcgggcat gacctcacag cgccacctcg
    21721 tggaactgtt ctcgctggac ggcctggtcg ccgtggtgac cggcgggagc tccggcatcg
    21781 gacgggccgt ggccggcgcc ctcgcacgcg ccggggccgg cgtcgtcatc gtggcgcgca
    21841 gggaggccga actggcctcc gccgtagacg agttcgcggc agacggctgc cgggcggcct
    21901 gggtgagcgc cgatctcggc acgcgtgagg gggtgcgcgc cgcggcggag caggcggccg
    21961 gggtgttcgg cgagccggac atcctcgtga acagcgcagg gatcaacctg cggccgccga
    22021 tgggcgagct ggacgacgcc gtgtgggacg ccacgatggc ggtgaacctg gaggcgccct
    22081 acctgctggg gcagcgcttc gggcccggca tggcggagcg gggcttcggg cggatcatcc
    22141 acatcagctc gcagcaggcg caccgggcgt tcgtgcagag cggcgcctac ggggtgtcga
    22201 agggggcgct cgagtcgctg gcccgttcgc aggccgaggc ctggtcgccg cacggggtca
    22261 cgtgcaacgc gctggtgccc ggcttcgttg tgaccccgct caacgcgcgg ctgtcgtccg
    22321 acgaggagac ggtggcggcg ctggcccggc ggacgctggt cggacggaac ggcctggccg
    22381 aggacttcgc cggtgcggcc gtgttcctcg ccggccggtc gtccggctac atcacgggcc
    22441 aggcgatctt cgtggacggc gggttctcgg cccactgagc ctccccgcgc cgctctcccg
    22501 ccggtgccgg ccgcgcctgc gcagggggga ggcccccgca tgcggtggtg ggctggtgcc
    22561 gccaccgcac cggaggtcgt catcggggcc gggaaccgcg gcggtcgagc agccggcggg
    22621 ctcgcgggac cgtgctgcta gttgccgatg ccggagctgc cgacgcccgt gtt
//
