LOCUS       NZ_CP030862            12178 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces globosus strain LZH-48 chromosome, complete genome.
ACCESSION   NZ_CP030862
VERSION     NZ_CP030862.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globosus
  ORGANISM  Streptomyces globosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Draft genome Sequence of streptomyces globosus LZH-48
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Institute of Biophysics, Dezhou University,
            566 DaXuexi RD, Dezhou, Shandong 253023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Portal v. version 2.2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003325375.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:22:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,671
            CDSs (total)                      :: 6,576
            Genes (coding)                    :: 6,458
            CDSs (with protein)               :: 6,458
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 41 of 118
            Pseudo Genes (incomplete)         :: 101 of 118
            Pseudo Genes (internal stop)      :: 11 of 118
            Pseudo Genes (multiple problems)  :: 32 of 118
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:39:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3512825
            Orig. end                         :: 3525003
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030862.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..12178
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="19"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12178
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12178
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7178](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7178
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(320..1816)
                     /locus_tag="C0216_RS15295"
                     /old_locus_tag="C0216_15270"
     CDS             complement(320..1816)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013504.4"
                     /locus_tag="C0216_RS15295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15270"
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_114055830.1"
                     /transl_table=11
                     /translation="MTTARRLLRAAASPALAAALLASTAPSASAADPQPVYGELAANGT
                     FAAGTAGWWSAGASIASAGGALTATATGGTQNPWDAIVGQNGLRLRRGATYTLSFDAKA
                     SAPARLRATAQLGGAPYTAALDRTVDLATVSKRFTWTFTSGIDTATGALNFQIGGQPAT
                     TAITLDNVSLTTSTAREGFYVDPANNAAAWVAGNPGDPRAAKIKAAVADHNTSKWFGDW
                     DADRDPATGIQTEVSDHVGAAAAQGRLPVLVAYNIPGRDCGGASSGGAGSPAAYKAWID
                     KFAQGIAGRPAVVVLEPDAVAQSSDDACMKGAAEERFDMLRYATQRLRDQGGFVQTYLD
                     AGNATWTLGPDLSGTQGIGLERMAYLLDRSGVAAARGVSVNVANFDATAVADDYGKRLA
                     ARLKADFGVTSRWVVDTARNGNGGYVVPGDPGSGHVGFCNPGKRKLGVTSRAGSAGGAE
                     YQLWLKNPGDSDGNSAECPAGSPPAGAFSPVLAEALIDGR"
     gene            2227..2916
                     /locus_tag="C0216_RS15300"
                     /old_locus_tag="C0216_15275"
     CDS             2227..2916
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS15300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_15275"
                     /product="hypothetical protein"
                     /protein_id="WP_114055831.1"
                     /transl_table=11
                     /translation="MLPFATRADAGTPDLARTALAARDGWASSGSGTTGGQAADAAHDT
                     TVTTRAELVKALRAGPSGAPRIIRIKGRIDAKTDDQGRRLDCADYAKGTGYTLAAYLKA
                     YDPAVWGRSELPAGAQEPARAAAQARQAERIAIAVPSNTTVVGVPGTDAGINGGSLLVQ
                     KADNAVYRWTPKPGRTVPPGEHVFAVQYNHARGPRAPGADTYTATAATAGGRQHTVTGP
                     VRAPGGG"
     gene            complement(2921..3970)
                     /locus_tag="C0216_RS15305"
                     /old_locus_tag="C0216_15280"
     CDS             complement(2921..3970)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016576508.1"
                     /locus_tag="C0216_RS15305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15280"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_246042550.1"
                     /transl_table=11
                     /translation="MRLSPVILTVVIAGLAYATPPEMAFSRLLPAAPALAAAMWPVLPT
                     VLLGTVCLLLMIGLGFVFPDLGTWWTAAGIIAVTVAAAYGSHARLQRERTLFQVRLVAD
                     AAQQVVLSPLPRRFGNVEIESLYLAAAAEASIGGDFYEVVDTPYGVRLLIGDVRGKGLP
                     AVGAAAAIVNAFREAAYGEADLVDVARRLDASSARYNAAFPPDGPMERFATALLAEIPH
                     EGGRIRILNCGHPPPLILNRRELRVLEPDSPSPLLSLAELIGQHYTVDTFDLSPGDLLL
                     LYTDGIAEARSRDGEFFPLAAWMRRQPQTPPRELLAALHGDLLRYSRGRLDDDVAALAV
                     RLGEGRGSG"
     misc_feature    4090..4105
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.24"
                     /tool="antismash"
     gene            complement(4358..4504)
                     /locus_tag="C0216_RS33885"
     CDS             complement(4358..4504)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059383.1"
                     /locus_tag="C0216_RS33885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_174250402.1"
                     /transl_table=11
                     /translation="MSGLLARLKVFSRSPQGRRAIASVRRAAADPRRQEQARRLLGSLR
                     GRR"
     misc_feature    complement(4702..4714)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.14"
                     /tool="antismash"
     misc_feature    complement(4702..4717)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            5001..7178
                     /locus_tag="C0216_RS15310"
                     /old_locus_tag="C0216_15285"
     CDS             5001..7178
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998132.1"
                     /locus_tag="C0216_RS15310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15285"
                     /product="YcaO-like family protein"
                     /protein_id="WP_114055833.1"
                     /sec_met_domain="TIGR03604 (E-value: 4.1e-78, bitscore:
                     261.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 9.5e-65, bitscore: 217.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAEDTAWELLDTEVYDLGQDMCFLATPNGGQFYISAPPDEFRAW
                     LARCDGTRTRTELLAGMSPDYAEVVDVLRDDGCLRPAGAARDADRAARIARTTVLLTGA
                     PELTNPLAHALATTGYRHVGPAPEDLIAIDAADLTDTVLVAAFPHPAHAELGRLDGLCA
                     RLGLRWLPLRHERGRAVLGPAITPGVSADFTDVLERRLSAAADPRIPEAMRAAPPPGAR
                     RLRGGDIRWTASQLAVSLERWISGEAAVDEAELDPRRLTRLERTILPVPTRPRPVVRGN
                     PDDDLLLDDQVGVVTGVQELAPLPGMPAQLRVCAVDVADMRRVADWPNDRQAFGTSWSD
                     FDAARRSAVGEAVERYCGSRLPEDRLRFGSHASLRRAGIPALDPRRLHLYSERQYRSDG
                     FPFAPLTTDAECSWVEGRSWTTGEPVWVPAFLVAHGEHDPLPYSDPLVAGVACGTSEEH
                     AVTSGLEEVIERDTTMLWWANAARLPRLPMTDRLRALTADSADAYDTTLIPLDNEFGVP
                     VLAAVVRDRATGWLAIGFATRPDPYEAAEKALAEGFTLHHTCRFLDDEKALGDGVADLP
                     HLGNLMPYRADRRYLDSYRPDFADVRDLLCQQQLHLDPRAGEHVAPWLEDLPFRPWHGL
                     PALGERRLAAYRERVEARGFEVISVDLTTCDAEAAGFSAAHTIVPGLVSNFPAGMPMWG
                     NGRIGRAGVRLGWRPQPLAETEYNVFPLPHA"
     misc_feature    5048..5068
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.77"
                     /tool="antismash"
     gene            7187..8446
                     /locus_tag="C0216_RS15315"
                     /old_locus_tag="C0216_15290"
     CDS             7187..8446
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998131.1"
                     /locus_tag="C0216_RS15315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15290"
                     /product="MFS transporter"
                     /protein_id="WP_114055834.1"
                     /transl_table=11
                     /translation="MAVIDTFGLPNTKGRRPLIVAQIVDALGTGLFLPFAVVYFHAAKG
                     IPLTTVGLMLSTGALLSLPAGPLGGRLIDRIGPRRVLVSANLIRVLTFTAYVFTDTPWQ
                     LVLLVTATMWGDSLFRPSVFALVAQVADDGHRARWYAMDRSLRNAGIGAGGLIGSTFVG
                     WGGTSGYTAVVVLNALSFLLAAGLVATWRRGALRSPAAPAPADAARKAEPRAGYREVLA
                     DRPFLAVLTTTWVFALCDLALTLLLSAYIIEGRGLPEWQPGMLFAINTVMVVLGQTALA
                     KAVERYRRPAVLQTAAVLWMASFLVIAAVPGDHASLAFCGLVLGMVVFTVAELLQAPTT
                     SALIVGMAAGHLRGRYLGMEELMWSLAKVLAPTVFTGLLAFGAALPWLMLCAFCLVAVV
                     LLQRLNRVLPAHVQRETADV"
     gene            8439..8975
                     /locus_tag="C0216_RS15320"
                     /old_locus_tag="C0216_15295"
     CDS             8439..8975
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998130.1"
                     /locus_tag="C0216_RS15320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15295"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_114055835.1"
                     /transl_table=11
                     /translation="MSEPGSAPLHLGEFREVYHRVYREPPYHEDTADADGFARQLAGHA
                     ALPGFAVATVRDGATLTGFAYGVHRGAGWWHPRAAAPAPRWLRRLPLFYVYELAVVREA
                     RGRGHGRLLLDRLLADRSEPYAVLAASGKAPARDMYRRWGWTEAGRLTGPPHGVDLLVL
                     PLPQQHRPDRRGETG"
     gene            8972..9571
                     /locus_tag="C0216_RS15325"
                     /old_locus_tag="C0216_15300"
     CDS             8972..9571
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="C0216_RS15325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15300"
                     /product="response regulator transcription factor"
                     /protein_id="WP_114055836.1"
                     /transl_table=11
                     /translation="MNTDVLVHDDLALSRAALTALLDGFPGLTVVASADSAYAALEFAE
                     LHRPDVVLISFGGRDEETLEAAEKIAVLPGSRTLLLATACPRPLVRRALAGGIGGLVRR
                     SDPPERLAEAVRRVHRGERVFDDGPAAAPGGDCPLTRRQLSVLELLHRGDPVPQIAARL
                     SLSEGTARNYVSAVVSAMGARNRIDALRMAREREWI"
     gene            9674..11368
                     /locus_tag="C0216_RS15330"
                     /old_locus_tag="C0216_15305"
     CDS             9674..11368
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018092540.1"
                     /locus_tag="C0216_RS15330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_15305"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_114055837.1"
                     /transl_table=11
                     /translation="MPHSTAPSGGRLPREVADAHVDAFVALDPIAATFLGVAAGSDRLP
                     DLSPDGRHAAADLARTTLRQLAEAEREPGADTAAERRCARLLRERLTAELAVHEAGEHL
                     RTVGNLGSPLHEVRDVFTLTPQDTAEDWAAIGRRLYAVPDALAGYQASLGTGLARGLTA
                     GPRQTAAVIGQLTEWIGTDRSWFQEFTDPCPEPLRPGLDGAAAAATGALAELRDWLRDT
                     YAPAVADAPDVAGRERYVRLARHHNGTDLDLDEAYAYGWAEFRRLLAEMRTEAARVLPG
                     ATDPWEALAWCDRHGDAVEGVEETRQWLQTLMDDTIGLLDGTHFELAPRVRRVESHIAP
                     RGSAAAPYYTEPSLDFSRPGRTWLPTMGETRFPVYDLVTTWYHEGVPGHHLQLAQWAHV
                     ADDLSRYQTTLGLVGANAEGWALYAERLMDELGFLTDPQRRLGYLDAQMMRAVRVIVDI
                     GMHLELEIPKDSPFHPGERWTPSLAQEFLGRHTSRPADYVESEITRYLGMPGQAIGYKL
                     GERVWLAGREAARARHGAGFDLKAWHMAALSQGSLGLDDLLGELSAL"
ORIGIN
        1 cagggcggat aggccgccca tgcccggata ccggtgcgcg gcatgcggcc accagcggat
       61 cgtccactcc gtcctgcgcg gcggcagctg ccggggcagc ctctcctgcg agtgccgcga
      121 gagccgcgcg ggcattcccg ccgcgccgcg cccggccgcg gcccctcagg agccgtcgga
      181 gccggaatgc gccgcctgcc ggtcaccctt cggcgcgtgc cggtgcgact cctggtgggc
      241 ccgcgacgac ggccggcacg gcccctgcgg cggatgcggc gggtaggcgt cccggccgca
      301 ccgccgcggg tgccgcccgt cagcggccgt cgatcagcgc ctccgccagc accggcgaga
      361 acgcgccggc cggcggcgaa cccgccgggc actcggcgga gttgccgtcc gagtcgccgg
      421 ggttcttgag ccacagctgg tactcggcgc cgcccgcgct gccggcccgc gaggtcacgc
      481 ccagcttgcg cttgcccggg ttgcagaacc cgacgtggcc gctgcccgga tcgccgggga
      541 cgacgtaccc gccgttgccg ttgcgggcgg tgtcgaccac ccagcggctg gtcaccccga
      601 agtcggcctt cagccgggcc gccaggcgct tgccgtagtc gtcggcgacg gccgtcgcgt
      661 cgaagttcgc cacgttgacc gacacgccgc gcgccgctgc gacacccgag cggtcgagca
      721 ggtacgccat ccgctccagg cctatgccct gcgtgccgct caggtccggg ccgagcgtcc
      781 aggtggcgtt gccggcgtcc aggtacgtct gcacgaagcc gccctggtcc cgcagccgct
      841 gggtcgcgta ccggagcatg tcgaagcgct cctcggcggc gcccttcatg cacgcgtcgt
      901 cggaggactg ggccacggcg tccggctcca gcacgacgac cgccgggcgg cccgcgatgc
      961 cctgcgcgaa cttgtcgatc cacgccttgt acgcggccgg agagcccgcg ccgccggagg
     1021 aggcgccgcc gcagtcccgg cccgggatgt tgtaggcgac cagcaccggc agccggccct
     1081 gcgccgccgc ggcgcccacg tggtccgaca cctccgtctg gatgccggtg gcgggatccc
     1141 ggtcggcgtc ccagtccccg aaccacttcg acgtgttgtg gtccgcgacg gccgccttga
     1201 tcttcgcggc gcgcgggtcg cccgggttgc ccgcgaccca ggccgccgca ttgttggccg
     1261 ggtcgacgta gaagccctcg cgggcagtgg aggtggtcag cgagacgttg tcgagggtga
     1321 tggccgttgt ggccggctgc ccgccgatct ggaagttcag ggccccggtg gcggtgtcga
     1381 taccggaggt gaacgtccag gtgaagcgct tggagacggt cgccaggtcg accgtgcggt
     1441 cgagcgccgc cgtgtagggg gcgccaccga gctgcgccgt cgcgcgcagt ctcgccggcg
     1501 cggacgcctt ggcgtcgaag gacagtgtgt acgtcgcccc ccggcgcagc cggaggccgt
     1561 tctggccgac gatggcgtcc cacgggttct gcgtcccgcc ggtggcggtc gcggtgaggg
     1621 cgccgccggc ggaggcgatg gacgcgccgg cggaccacca gccggcggtg ccggcggcga
     1681 aggtgccgtt ggccgccaac tcgccgtaga ccggctgagg gtcggccgcc gaggcggacg
     1741 gggcggtcga ggcgaggagg gcggcggcca gtgcgggact ggcggctgcg cggagcagtc
     1801 tgcgtgcggt cgtcatggtg gaacggcctc cttcggtcgc ggtgggggcc ggcctgaacg
     1861 gcgcgggggc acagccgggc cgggtccccc ctcgtgtgcc tgcccgaggc aggcgcacgg
     1921 accccacacc catgatcact ggaccgcggg ccgcgacgcg acccgggccg gtcacgcctc
     1981 cctctcaaat cccctggcgg aggcccgagt tcgccggcgg gcgatgtggc gcagctctca
     2041 ccccttccgc cgcctgcggc aacccttccg cgcccggcgg caaccggggg acgacagaca
     2101 gcagttcccg acagccgctc cccccgaagg agaaccaccc cgtgaccctt ccctccgacc
     2161 gccgcttccc ccgccgccgc ctggtcctcg cgtccgcggg cgctcgccgc cgtcgccggc
     2221 ctcggcgtgc tgcccttcgc cacccgcgcg gacgcgggca cccccgacct cgcgcgcacc
     2281 gccctcgccg cccgcgacgg ctgggcgtcg agcggctcgg gcaccaccgg cgggcaggcc
     2341 gccgacgcgg cgcacgacac aacggtcacc acccgggccg agctggtcaa ggcgctccgc
     2401 gccggcccat ccggagcccc gaggatcatc cggatcaagg ggcggatcga cgccaaaacc
     2461 gacgaccagg gccgccggct cgactgcgcc gactacgcga agggcaccgg ctacacgctc
     2521 gccgcctacc tgaaggcgta cgaccccgcc gtctggggcc gctccgaact gcccgccggc
     2581 gcccaggagc cggcgcgggc ggccgcccag gcccggcagg ccgaacgcat cgccatcgcc
     2641 gtgccgtcga acaccaccgt cgtcggcgtg cccggcaccg acgcgggcat caacggcggc
     2701 agcctcctgg tgcagaaggc cgacaacgcc gtctaccggt ggacccccaa gccgggccgc
     2761 accgtccccc cgggggagca cgtcttcgcc gtccagtaca accacgcccg gggcccgcgg
     2821 gccccgggcg ccgacacgta caccgcgacg gccgccaccg ccggagggcg gcagcacaca
     2881 gtcaccggcc cggtccgcgc accgggcgga ggctgacccc ctacccggag ccccggccct
     2941 cgcccagccg gacggcgagg gcggcgacgt cgtcgtcgag gcggccccgg ctgtagcgca
     3001 gcaggtcgcc gtggagggcg gcgagcagct cgcggggcgg cgtctgcggc tgtcggcgca
     3061 tccaggccgc cagcgggaag aactcgccgt cgcgggagcg ggcctcggcg atcccgtcgg
     3121 tgtagaggag cagcaggtcg ccgggggaga ggtcgaaggt gtccacggtg tagtgctggc
     3181 cgatcagctc cgccaggctg agcagcggcg acggcgagtc gggttccaga acgcggagct
     3241 ccctccggtt caggatcagc ggcggcgggt gcccgcagtt gaggatgcgg atgcgtcccc
     3301 cctcgtgcgg gatctcggcg aggagcgcgg tggcgaagcg ctccatgggg ccatccgggg
     3361 gaaaggcggc gttgtagcgg gcgctgctgg catccagcct gcgcgcgacg tcgaccagat
     3421 cggcctcgcc gtacgcggcc tcccggaagg cgttgacgat ggccgccgcg gcgcccaccg
     3481 ccgggaggcc cttgccgcgg acgtccccga tcagcagccg gaccccgtac ggggtgtcca
     3541 ccacctcgta gaagtccccg ccgatgctgg cctccgctgc ggccgccagg tacagcgact
     3601 cgatctcgac gttcccgaag cggcgcggca gggggctcag caccacctgc tgtgccgcgt
     3661 ccgccacgag gcgcacctgg aagagggtgc gctcccgctg aagccgggcg tggctgccgt
     3721 acgcggcagc cacggtgacc gcgatgatcc ccgcggccgt ccaccacgtc cccaggtcgg
     3781 ggaagacgaa gccgaggccg atcatcagga ggaggcacac cgtcccgagc aggacggtgg
     3841 gcaggaccgg ccacatggcg gcggcgaggg ccggggccgc cggcaggagg cggctgaagg
     3901 ccatctccgg cggcgtggcg taggccaggc cggcgatgac gacggtcagg atgaccggcg
     3961 acagccgcac aagccttccc gggccggggc gccgacgggg ctgcggccgt ccggtctcga
     4021 tcacatctac agactatcca tgcaaagagg acaaagcgcc ccggcgaggc cgcgcaaccc
     4081 cgtctgaaat cgaacgtatg agtgaaaatg gcgggcgatg gccagaccat gccgttctac
     4141 tggctccacc ccgacggcgc ccacgccgtc agcgccctcc tcacccccgc acagccgctc
     4201 gtccccgccc tcggcaaccc gtgacccgga ccggctgcac accgccgagc agcccgaccg
     4261 ccttcgctgg ccgcacgcgc gggatccgcg cggagtgccc gggcaccgtc ggccccgaag
     4321 gaggggcggg ggagaacccc gcccctcctc ccgctcgtca gcgccggccg cggagactgc
     4381 cgaggagcct gcgcgcctgc tcctgcctgc gcgggtccgc agcggcccgg cgtaccgacg
     4441 cgatggcccg ccgcccctgg gggctgcggc tgaacacctt gagcctggcg agtagtccgg
     4501 acacggttcc ctcccggtgt ggcccgtcgt ttcgacgccg tgtgccccgg ccccgcccgc
     4561 gcaaacggcg gccccggggg gatttgcatt cgccgtgggg gcccaaaacg ccgatgagca
     4621 gggaaaacgc ctgcggaaca agccctcccg cggggcggaa tctggagtgc ggatggagcg
     4681 cggctttaat tgcggcggaa tgtgaaaaac gcatctgtgc aaggccgttg gaggcccgta
     4741 acgtatttcc cgtaagcacg accgaacgga aaacaggagg aaaaaccatg atctccaccg
     4801 tcaaggccag cgccgtcacc gccgtcgtcc acaaccgcgc cgtggtccac aaccgggccg
     4861 tcgtccacaa ccgcgcggtc gtgcacaacc gcacggtggc caagtgaagc tgaccgtcta
     4921 aggtccttct cccacggccc cgggatccat cccccggggc cgtggccctt tgtatcggaa
     4981 ctcgtttcat gggggcggta atgccggcgg aagacaccgc ttgggaactc ctggacaccg
     5041 aggtgtacga cctcggacag gatatgtgct ttcttgccac accgaacggc ggacagttct
     5101 acatttccgc cccgccggac gagttccgcg cctggctggc acgctgcgac ggcaccagga
     5161 cccgcaccga actgctcgcc ggaatgtccc ccgactacgc cgaggtcgtc gacgtcctcc
     5221 gggacgacgg ctgcctgcgc ccggccgggg ccgcccgcga cgccgaccgg gccgcccgca
     5281 tcgcccgcac caccgtgctc ctcaccggcg cgcccgaact gaccaacccc ctcgcccacg
     5341 cgcttgccac caccggatac cggcacgtcg ggccggcccc cgaagaccta atcgcgattg
     5401 acgccgccga tctcaccgac accgtgctcg tcgccgcctt cccccacccc gcgcacgccg
     5461 aactcggccg actcgacgga ctgtgcgcgc gactcggcct gcgctggctg ccgctgcgcc
     5521 acgaacgcgg ccgggccgtc ctcggccccg ccatcacccc gggcgtctcg gccgacttca
     5581 ccgacgtact ggagcgccgg ctcagcgcgg ctgccgaccc gcggatcccc gaagccatgc
     5641 gggccgcgcc gccacccggg gcccgccggc tccgcggcgg cgacatccgc tggaccgcct
     5701 cccaactcgc cgtgagcctg gagcgctgga tcagcggcga ggccgccgtc gacgaggccg
     5761 agctcgatcc gcgccgcctc acccgcctcg aacgcaccat cctgcccgtc cccacccggc
     5821 cgcggcccgt ggtccgcggc aaccccgacg acgacctgct cctcgacgac caggtcggcg
     5881 tggtgaccgg agtccaggag ctggctccgc tccccggcat gcccgcgcaa ctgcgggtgt
     5941 gcgccgtgga cgtcgccgac atgcggcgcg tcgcggactg gcccaacgac cggcaggcgt
     6001 tcggcacgtc ctggtccgat ttcgacgccg cccgccgcag cgccgtcgga gaggcagtcg
     6061 aacgctactg cggcagccgg ctccccgagg accgcctccg cttcggcagc cacgcgagcc
     6121 tgcgccgggc cgggatcccc gcgctcgacc cgcgccgcct acacctgtac tccgagcggc
     6181 agtaccgaag cgacggcttc cccttcgccc cgctgaccac cgacgccgag tgctcctggg
     6241 tcgagggccg ctcctggacg accggcgaac cggtgtgggt gcccgccttc ctcgtcgccc
     6301 acggcgagca cgacccgctc ccgtactccg acccgctcgt cgccggcgtg gcctgcggca
     6361 ccagcgagga gcacgccgtc acctccgggc tcgaagaggt catcgagcgc gacacgacca
     6421 tgctgtggtg ggcgaacgca gcccgcctgc cccggctgcc gatgacggac cggctccgcg
     6481 ccctcaccgc ggacagcgcc gacgcctacg acaccaccct gatccccctg gacaacgagt
     6541 tcggtgtccc cgtactcgcc gccgtcgtcc gcgaccgcgc caccggctgg ctcgccatcg
     6601 gcttcgccac ccgccccgac ccgtacgagg cggcggagaa ggcgctcgcc gaggggttca
     6661 cgctgcacca cacctgccgc ttcctcgacg acgagaaggc tctcggggac ggtgtggcgg
     6721 acctgccgca cctcggcaac ctcatgccgt accgcgccga ccgccgctac ctcgactcct
     6781 accgccccga cttcgcggac gtccgcgacc tgctgtgcca gcagcagctc cacctcgacc
     6841 cgcgggccgg cgagcacgtc gcgccctggc tggaggacct ccccttccgc ccctggcacg
     6901 ggctgcccgc cctcggcgag cggcgcctcg ccgcctaccg ggaacgcgtc gaggcccgcg
     6961 gattcgaggt catcagtgtc gacctgacga cctgtgacgc cgaggcggcc gggttctccg
     7021 ccgcgcacac gatcgtgccg ggcctcgtgt cgaacttccc cgccggcatg cccatgtggg
     7081 gcaacggcag gatcggccgc gccggcgtcc ggctgggctg gcggccgcag ccgctcgccg
     7141 agaccgagta caacgtattc ccgctacccc acgcgtgagg gacacgatgg ctgtcatcga
     7201 cacgttcggc ctgcccaaca ccaagggccg caggcccctg atcgtcgcgc agatcgtcga
     7261 cgccctgggc accggcctct tcctgccctt cgcggtggtg tacttccacg ccgccaaggg
     7321 catccccctg accacggtcg gcctgatgct gtcgaccggc gccctgctct ccctgcccgc
     7381 gggcccgctc ggaggcaggc tgatcgaccg gatcgggccg cggcgcgtcc tcgtctcggc
     7441 caatctgatc cgcgtcctca ccttcaccgc ctacgtgttc accgacaccc cctggcagct
     7501 cgtcctcctc gtcacggcca ccatgtgggg cgacagcctc ttccggccct ccgtcttcgc
     7561 cctcgtcgcc caggtcgccg acgacgggca ccgggcccgc tggtacgcga tggaccgctc
     7621 cctgcgcaac gccggtatcg gcgcgggcgg cctcatcggc agcactttcg tcggctgggg
     7681 cggcacctcc ggctacaccg ccgtcgtcgt cctgaacgcc ctgtcgttcc tcctcgccgc
     7741 cgggctcgtc gcgacctggc gccggggcgc cctccggagc cccgccgccc ccgccccagc
     7801 cgacgccgcc cggaaggcgg aaccgcgcgc cggctaccgg gaggtcctcg ccgaccggcc
     7861 gttcctcgcc gtcctcacca ccacctgggt gttcgccctg tgcgacctgg cgctgaccct
     7921 gctgctgagc gcgtacatca tcgaggggcg cgggctcccc gagtggcagc ccggcatgct
     7981 cttcgcgatc aacacggtca tggtggtgct cggccagacc gccctggcca aggccgtgga
     8041 gaggtaccgg cggcccgccg tgctccagac ggcggccgtc ctgtggatgg cgtccttcct
     8101 ggtcatcgcg gccgtgcccg gcgaccacgc gagcctcgcc ttctgcgggc tcgtcctcgg
     8161 catggtcgtc ttcacggtcg ccgaactgct ccaggccccc accaccagcg cgctgatcgt
     8221 gggcatggcc gcggggcacc tccgcggccg ctacctgggc atggaggagc tgatgtggag
     8281 cctcgccaag gtgctggcgc cgaccgtgtt caccgggctg ctggccttcg gggccgccct
     8341 gccgtggctc atgctgtgcg ccttctgcct cgtcgccgtc gtcctgctcc agcggctcaa
     8401 ccgggtgctg ccggcgcacg tccagcggga gaccgccgat gtctgagccc ggctccgcac
     8461 ccctgcacct cggcgagttc cgcgaggtct accaccgggt ctaccgcgaa ccgccctacc
     8521 acgaggacac ggcggacgcg gacggcttcg cccggcaact cgccggccac gcggccctgc
     8581 cgggcttcgc cgtcgccacc gtccgcgacg gcgcgaccct gaccgggttc gcctacggag
     8641 tccaccgagg ggccggctgg tggcacccgc gggccgccgc ccccgcacct cggtggctgc
     8701 gccgcctgcc gttgttctac gtgtacgagc tcgcggtcgt ccgggaggcc cgcggccgcg
     8761 ggcacggccg cctgctcctc gaccggctgc tggccgaccg cagcgagccg tacgccgtcc
     8821 tggccgcatc cgggaaggcg ccggcccgcg acatgtaccg gcggtggggc tggaccgagg
     8881 cgggcaggct gacgggcccg ccgcacggcg tggacctcct cgtcctgccg ctgccgcaac
     8941 agcaccgtcc cgaccgccgc ggggagaccg gatgaacacc gacgtgctgg tccacgacga
     9001 cctcgccctg tcccgcgccg cgctcaccgc cctcctggac ggcttccccg gcctcaccgt
     9061 cgtcgcatcc gccgacagcg cctacgccgc cctggagttc gccgaactcc accgtcccga
     9121 tgtcgtcctc atcagcttcg gcggccggga cgaggagacc ctcgaggccg ccgagaagat
     9181 cgccgtcctc ccgggcagcc gaaccctgct cctcgccacc gcctgccccc ggcccctcgt
     9241 ccgcagggcc ctcgccggcg gcatcggcgg actggtccgc cgcagcgacc cgcccgaacg
     9301 cctcgccgag gccgtccgcc gcgtgcaccg cggagagcgg gtcttcgacg acgggcccgc
     9361 ggcagcgccg ggcggggact gcccgctcac ccgccggcag ctgtccgtcc tcgaactcct
     9421 ccaccgcggc gaccccgtcc cgcagatcgc cgcccggctc tccctgtccg aaggcaccgc
     9481 ccgcaactac gtctccgccg tcgtgtccgc catgggcgcc cgcaaccgca tcgacgcgct
     9541 gcgcatggcc cgcgaacggg agtggatctg atcccggccg ccccggcccc gcaccccgcc
     9601 ccgcccgcac accccccacc gacccgccgg cccccatccc gccgacgcac ccacccgtac
     9661 aaggacggct cgcatgcccc actccaccgc ccccagcggc ggcaggctgc cccgggaggt
     9721 cgccgacgcc cacgtcgacg ccttcgtcgc cctcgacccg atcgccgcca ccttcctcgg
     9781 tgtcgccgcc ggctccgacc gcctccccga cctctcgccc gacggccggc acgccgccgc
     9841 cgacctggcc cgcaccaccc tgcgacagct cgccgaagcc gagcgggagc ccggcgccga
     9901 caccgccgcc gaacgccgct gcgcccgcct gctccgcgag cggctcaccg ccgaactcgc
     9961 cgtccacgag gccggcgagc acctccgcac ggtcggcaac ctcggctcgc cgctgcacga
    10021 ggtccgcgac gtcttcaccc tcacccccca ggacaccgcc gaggactggg cggcgatcgg
    10081 acggcggttg tacgccgtcc ccgacgccct cgccggctac caggcttccc tgggcaccgg
    10141 actcgcccgc ggcctcaccg cggggccccg gcagaccgcc gccgtcatcg gccagctgac
    10201 cgagtggatc ggcacggacc gcagctggtt ccaggagttc accgacccct gccccgagcc
    10261 gctgcgcccc gggctcgacg gcgccgccgc ggccgccacc ggtgccctcg ccgaactccg
    10321 cgactggctc cgcgacacct acgcgccggc cgtcgcggac gcgccggacg tcgccggcag
    10381 ggagcgctac gtccgcctcg cccgccacca caacggcacc gacctcgacc tggacgaggc
    10441 ctacgcctac ggctgggccg agttccgccg gctgctcgcc gagatgcgca ccgaggccgc
    10501 acgcgttctg cccggcgcca ccgacccgtg ggaggcgctg gcctggtgcg accggcacgg
    10561 cgacgccgtc gaaggcgtcg aggagacccg gcagtggctc cagacgctga tggacgacac
    10621 catcggcctc ctcgacggca cccacttcga actggccccg cgcgttcgca gggtcgagtc
    10681 gcacatcgcc ccgcggggca gcgccgccgc cccctactac accgagccgt ccctggactt
    10741 ctcccggccc ggacgcacct ggctcccgac catgggcgag acccgcttcc ccgtctacga
    10801 cctcgtcacc acctggtacc acgagggcgt acccggccac cacctccagc tcgcccagtg
    10861 ggcgcacgtc gccgacgacc tctcccgcta ccagaccacc ctgggcctcg tcggcgccaa
    10921 cgccgagggc tgggcgctgt acgcggagcg cctcatggac gaactgggct tcctgaccga
    10981 cccgcagcgc cgcctcggct acctggacgc gcagatgatg cgggccgtcc gcgtcatcgt
    11041 cgacatcggc atgcacctgg aactggagat cccgaaggac tcgcccttcc acccgggcga
    11101 acgctggaca ccctccctgg cccaggagtt cctcggccgg cacaccagcc gccccgccga
    11161 ctacgtcgag agcgagatca cccgctacct gggcatgccc ggccaggcca tcggctacaa
    11221 gctgggcgag cgggtctggc tggcgggccg ggaggccgcc cgtgcccggc acggcgcggg
    11281 cttcgacctc aaggcctggc acatggccgc cctgtcgcag ggctcgctcg gcctggacga
    11341 cctgctcggc gaactctccg ccctctgacg cgcgcccgcg gggacccgcc cgcagggacc
    11401 cgcccgccct tgtgcggtct catccggcac accgcgagcc gatgcgggcg agcaccgcgc
    11461 cggcgccgtc ctccgccgcg atgcgacggg cgagggcggc cgcccggcgg cggtgggccg
    11521 gctcggacag gcaggcgcgg atcgcggcgc cgagggtttc ggcggtgagg tcccgcagcg
    11581 gcaggggccg ggtggccact cccagccggt gcagccgggc cgcccagaaa ggctggtcgg
    11641 ccatgacggg caccggcacc gccggcaccc cggcccgcag cccggccccg gtcgtgcccg
    11701 ccccggcgtg gtggacgacg gccgcggtgc gggggaacag ccagtcgtgc gggacgtcgc
    11761 cgacggccag gacgccgtca ccgcagccgg ccaggccggc ccacccggcc tggaccaccg
    11821 cccgcacccc cgcccgccgc acggccgcgg ccaccagcgc gctgagccgt tccccctgcc
    11881 cggccgccat gctgccgaac ccgacgaaca ccggcggcgg ccccgcccgc aggaagtcgg
    11941 ccaggtcggc cgggggccgc cagccgtcgg gccgcgcggg ccaccagtac cccgacacac
    12001 cgaccccgga gggccagtcg cgggggcggg gcaccaccag cgggctgaag ccgtggaaca
    12061 caggccggac gccgtccggc tgcacgggcg cctcggccgg cagtccgagc cgcccgcgca
    12121 gccgggccgc ggcgcccgcg aagaccccgg ccgcacgcgc caccacgtcc cggcccgc
//
