LOCUS       NZ_CP030862            21014 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces globosus strain LZH-48 chromosome, complete genome.
ACCESSION   NZ_CP030862
VERSION     NZ_CP030862.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globosus
  ORGANISM  Streptomyces globosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Draft genome Sequence of streptomyces globosus LZH-48
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Institute of Biophysics, Dezhou University,
            566 DaXuexi RD, Dezhou, Shandong 253023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Portal v. version 2.2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003325375.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:22:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,671
            CDSs (total)                      :: 6,576
            Genes (coding)                    :: 6,458
            CDSs (with protein)               :: 6,458
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 41 of 118
            Pseudo Genes (incomplete)         :: 101 of 118
            Pseudo Genes (internal stop)      :: 11 of 118
            Pseudo Genes (multiple problems)  :: 32 of 118
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:39:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3046595
            Orig. end                         :: 3067609
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030862.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21014
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="15"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21014
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21014
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11014](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11014)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            781..3108
                     /locus_tag="C0216_RS13195"
                     /old_locus_tag="C0216_13175"
     CDS             781..3108
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF045194.1"
                     /locus_tag="C0216_RS13195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13175"
                     /product="TIR domain-containing protein"
                     /protein_id="WP_114055463.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 8.7e-17,
                     bitscore: 59.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYARKRIFVSHAGPDLPWAEWIAWVLEQEGHEVDLDLWDWRMGE
                     RFEERVGAGLGERPGYDLVVMLLSPQYLDSPYAGREWEHALRAPAIRLLSPGRLLPVQI
                     KPLTGPVPPALAPLPRLVLHGLHSESEVIARLADAVRNAGATAGTDDRTAPAPASAPQP
                     GAGPVGRPAPSAAAGPAAPRLPGSADRPALWNIPGRHPGVQGREALIQQIRLQLLASSV
                     AAVPALHGLDGVGAHEVAQEYAQRFRGQYDLVWWIGAADRAAVRAGYADLAGRLGIAAA
                     PGSPLRPDRDRLLEALFADLATRPRWLVVLADAGPPESLADLLPPEPGHLLLLPAAGDW
                     TDPAAVRRNVQPGRPEQPEDPATGHRPAQSPPGPAGARSRPRPRVLAVATEWSSSRGGL
                     STFNRRMCRALSVAGADVYCLVPAFDKEEAAAASAAGVTLVEAERPPLWTGERSLLRKP
                     GPALPGPPDLVIGHGRVTGPAAQLLAEDHYPQARRIHVIHMVPDQIEWLKEDRADDPAR
                     RADDRSTTERLLGATAHRPVVLGPLLYSKYAKHFTVPTGGTRLLRVDPGFEPSSAEPRA
                     VPEGDPEVLVFGRAEDVLIKGLDTAAEAMGRLVRRAHRFRGVDLAVRGVPDGEDGGALR
                     ERLMAYAGSGDLNIVPKPFRTDPETLRADLHHASLVLLPSRREGFGLSAVEAIAAGTPV
                     LVSDASGLGLLLRETLGVAEAEQYVVETRGDDQDAERWSHAVEFLLRDRAAAFARAAEL
                     REHLAARFSWSRAAAALLAELP"
     gene            3148..4098
                     /locus_tag="C0216_RS13200"
                     /old_locus_tag="C0216_13180"
     CDS             3148..4098
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661473.1"
                     /locus_tag="C0216_RS13200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13180"
                     /product="AEC family transporter"
                     /protein_id="WP_114055464.1"
                     /transl_table=11
                     /translation="MGAAQALEKLVPVVLAFGCGVLLARRKVVPAESSKAFADYAFLFA
                     VPCFLFGNIHRSDLGALFDWRAVTGYAAAACTGAVLVGVVAWTAGVRDPRGAALRIMAG
                     VQVNTAYFSVPVFIMLFGNAAPIFPVLLFQVCVFSLVIISIMEWGRPGRVGSPARRLGS
                     AVSASLLTPVVIACNAGILLGLLPVTVPGVVLDAFAFVGDSASPVALFALGLHLGGSGL
                     KIRGTTREEMAVIAFKCAAMPLITYAVCRHLFGVEGEWLGHLVLIAAMPAPQNLFIFAQ
                     RYDVGVDLSAALVVKSSVVALLLLPLWTQWAVHLA"
     gene            complement(4196..5017)
                     /locus_tag="C0216_RS13205"
                     /old_locus_tag="C0216_13185"
     CDS             complement(4196..5017)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013661.4"
                     /locus_tag="C0216_RS13205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13185"
                     /product="peptidoglycan recognition family protein"
                     /protein_id="WP_114055465.1"
                     /transl_table=11
                     /translation="MTSSAQQQAPAAAPSHTRRSVFTGALALAAGAALPSFAAGRAFAA
                     DAAAPVIASCATWGARPSSEPVVVLANRPQRIIVHHTATANVTDYSQQRAFALARAIQT
                     YHMDAQGWIDTGQHFTVSRGAFVMEGRHSSLAELRGGARQVRAAHCVGQNTVSIGIENE
                     GTYTSEEPPAAQYAALADLCAYVCTQYRLPATAIYGHRDFNATSCPGDRLYALLPALRR
                     DVAERLGASASGAGTVPAPDPVRDPIRDLLDQAASGPLAALPEYLPAHLLP"
     gene            5235..5450
                     /locus_tag="C0216_RS13210"
                     /old_locus_tag="C0216_13190"
     CDS             5235..5450
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432880.1"
                     /locus_tag="C0216_RS13210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13190"
                     /product="hypothetical protein"
                     /protein_id="WP_114055466.1"
                     /transl_table=11
                     /translation="MPLDAVGRFLAALDPAHRDAVAGEPRKEQERLAAAWEEELESDTD
                     IDTLDELSPAAAESEAARRVMERRPR"
     gene            complement(5536..6480)
                     /locus_tag="C0216_RS35205"
     CDS             complement(5536..6480)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS35205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_342777104.1"
                     /transl_table=11
                     /translation="MYTLLGYVRYRRGRLAEAEDFVRNGLEIANRIGQDNPAQWYAVGT
                     LVETLLARGNLAEAQKVARDYRLGEGFPQAIVYPDPQTVFGRLLLAQGRVDEAERQLTE
                     AGRRLDLRGTRNPSWSSWQLDLALAQATHDTGLARATAEEAVARARAFGAASIIGQALR
                     VQAATVEPAQAAVLLEEAVAHLEQSPAACEFAHALVDHGTVLQTMGDPHRAAQQLYRGM
                     EVATACGADTLTDRARGLLAAAGLRPRRLHTSEQDTLTVAEAEAARHAALGLDNAAIGK
                     EMRMDPAVVGELLSAVFTKLGTNRTGLGRALGM"
     gene            6491..7225
                     /locus_tag="C0216_RS35210"
     CDS             6491..7225
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS35210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_342777105.1"
                     /transl_table=11
                     /translation="MRAAPALGLELQDAGVEELLRPARLVAVHEGDRDDDRHLEAEVLV
                     GPAHAAVERLLREVDGGAHGFAAHGGVPGAQAQDVPLGQTAADEPLGELGEQPRPGGRV
                     LLVAADRVPLELLGLHAQPGPGTGGPARLVVQQSDGLRQPARVRQSLGKAVRDRLAQRR
                     LGLRLLQCRPQLVDGGHRVVQEVRGAELEQHLRPVLRLRGFAQRPRQVAACRVGRTGGE
                     ALVGGLAQLLYDPRVALGVHLQ"
     gene            complement(<7925..8437)
                     /locus_tag="C0216_RS35215"
                     /pseudo=""
     CDS             complement(<7925..8437)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024589.4"
                     /locus_tag="C0216_RS35215"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSYAAEPRGGASRPLLERESEILAIQRAVDDLCGGSDLGSATRRG
                     GVLTFAGSAGIGKTTLLAEARRHAAERGCTVLFARGGEQEKQVPFHVMRQLIQPAYAAM
                     TEGERRESLGAWYDIVAPALGLTAAAQGPTAPDPQGVRDGLDWVVTQLSVRSAPVVLVL
                     DDAHWADA"
     gene            complement(8631..9986)
                     /locus_tag="C0216_RS13220"
                     /old_locus_tag="C0216_13200"
     CDS             complement(8631..9986)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742345.1"
                     /locus_tag="C0216_RS13220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13200"
                     /product="cytochrome P450"
                     /protein_id="WP_114055467.1"
                     /sec_met_domain="p450 (E-value: 3.8e-74, bitscore: 248.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHAGLEATGVQAPVAPGRLPLLGHAVPLWREPIAFLESLRDHGE
                     VVRLDIGTWPVHLLTSPELVHEVLVGRAEQFGRGRIFDRLRPVFGNGIVTTDGAFHRSQ
                     RRMIQPAFHRNHIARYAETMSRQAVAMAASWAPGREVCILTETRRYAVSSVAEMVFSGE
                     LSRPAVDEVHRSLPVVLEGMLLRAVMPKALDRLPIPPNVRFDTAAERLRAVIDDVIRQY
                     GEPQPEERHDLLTLLMSSTDPETGAAMPPEQVRDEVVSLLLAGTETSATTLAWALYEIS
                     RHPAVEERLQAEVDAVVGDRPVRPSDLPALGYTRHVFQEALRLHSPLLFTRRALAPLTL
                     GGIAIPEGAELAYSPYALHRDPALFRNPRVFDPDRWQPGAEKRPRPHRYIPFGAGQHKC
                     IGDTFGVAEIMTAIAAVTSRWRLTPAPGVTVREVPAGIPQPSALPLIPLPRR"
     misc_feature    complement(9927..9929)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..11014)
                     /locus_tag="C0216_RS13225"
                     /old_locus_tag="C0216_13205"
     CDS             complement(10001..11014)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742346.1"
                     /locus_tag="C0216_RS13225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13205"
                     /product="terpene synthase family protein"
                     /protein_id="WP_246042519.1"
                     /sec_met_domain="T1TS (E-value: 7.8e-66, bitscore: 221.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDFHLPFGNAKHPLAARANAEATSWVVRHELVTSAVDQFAGIGC
                     GHLAGRVSGDAPYERVLLLAQWMAWSFVLDDQHDHLIRKGEVAAWRPVVGAITEYLDTG
                     RITSPDLARNPLVSGFAELCDRILAGLSPDAATRYRTHVRLVLASLDQEAGNRGGSGRP
                     TVEEYILLRRHSSQILPMMDMVEAGLGLDLPQYVHEMRELRQLVASVLDVISWGNDVFS
                     LPKEHSCGDTNNLVSLVAAWEGRSLPDAVRAVEQRIQVRIEEYLAGRRRLFEVLDADPS
                     TDPPLRDAVARYVHSCEDWMIGADLWQRYECTRYRDERFAAGLESAYTRPDLVSVA"
     misc_feature    11257..11270
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.4"
                     /tool="antismash"
     misc_feature    11258..11271
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.82"
                     /tool="antismash"
     gene            11468..11917
                     /locus_tag="C0216_RS13230"
                     /old_locus_tag="C0216_13210"
     CDS             11468..11917
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS13230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_13210"
                     /product="hypothetical protein"
                     /protein_id="WP_114055469.1"
                     /transl_table=11
                     /translation="MTEHRPSDPYHPASDGPEGDVLGSYLEDLRDRLGGARFEALIRAV
                     QATCALLGDGPRPVLEVPGGGLPPDLRREYVALLAVMITGRADHRLVELPSADGDTGWA
                     VVDATAADAPAPGRLHVRAQPDGVAGPAGRLPTRAHPHRLPGQRG"
     gene            complement(11961..13817)
                     /locus_tag="C0216_RS13235"
                     /old_locus_tag="C0216_13215"
     CDS             complement(11961..13817)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018517968.1"
                     /locus_tag="C0216_RS13235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13215"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_114055470.1"
                     /sec_met_domain="Pkinase (E-value: 1.1e-42, bitscore:
                     144.6, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 1.5e-05, bitscore: 23.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGQHPRGGGGMEGTGRPVHFEPLGPDDPATVAGYRIAARLGAGG
                     MGKVYLSHTPGGRPVAVKVIRPEFAEDPEFRRRFAQEIRSAQRVQGLFTAPVIDADTDG
                     PHPWLATAYVPGPSLAAAVSAHGALPVETVLLLVAGIAEALQVIHGAGIVHRDLKPSNV
                     LLAADGPRVIDFGIAHAADATSLTGSGVAVGTPAFMAPEQAAGRGVGPATDVFALGQVA
                     AYAAAGAPAFGEGASHGVLYRIVHEEPDLSGVPERLSELVTRCLAKDPADRPSVAEVIA
                     LCQSANDATTLRRAEDWLPAAVTAEITARSAAPAAAPAPPAAAPAITPAPPAHPPTVPG
                     GVAHQSTAPGGVAHQATSPAGAPYTPAAAPQHAPAVPPAYPPQHGYQPAGPYTAPQFTP
                     AHPYPGHTGQFQVPPAQVAQRKPRGAVLAALAIGFAVAVSAVGYNVVKGKDSGSQAAGS
                     SAGADGSGSGSGSAGSAAKPSGAAPRPDPQPAEYKGINLVAGYHLTLGDESLRPQKGED
                     GGYELSYDTGSYLDAEAQGGSLVLLDPGQEGSLATCRAETRFTQNVKINQLGSGRQVCV
                     TTGTGHLGLVTVRGISPEDSPSKYLTLDVTVWRNAAVGSNSR"
     gene            14108..15268
                     /locus_tag="C0216_RS13240"
                     /old_locus_tag="C0216_13220"
     CDS             14108..15268
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005479142.1"
                     /locus_tag="C0216_RS13240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13220"
                     /product="alkaline phosphatase PhoX"
                     /protein_id="WP_114055471.1"
                     /transl_table=11
                     /translation="MERRTFLRGAVVGTSAAAFGGTLMRGAAYAAPAQPGAGPYGALGA
                     ADANGIMLPAGFTSRVIARSGQTVSGTSYTWHKAPDGGACYADGTGWIYVSNSEINPSG
                     GASAVRFNSSGSITSAYRILSGTRQNCAGGKTPWNTWLSCEEVSLGYVYETDPWGVNAA
                     VRRPAMGRFKHEAAAADPVRQAVYLTEDESDGCFYRFLPTTWGNLSSGTLQVLKAGSGT
                     SGSFTWQNVPDPDGSPTATRNQVSGAKRFNGGEGCHYANNTVWFTTKGDNRVWQLNLSS
                     NTYELAYDDSLVVGGGAPLTGVDNVTGSSFGDLYVAEDGGNMEICVITPDDVVAPFLRI
                     TGQSSSEICGPAFSPAGDRLYFSSQRGTSGSSSGGITYEVTGPFRT"
     gene            15399..15713
                     /locus_tag="C0216_RS13245"
                     /old_locus_tag="C0216_13225"
     CDS             15399..15713
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891762.1"
                     /locus_tag="C0216_RS13245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13225"
                     /product="PRC-barrel domain containing protein"
                     /protein_id="WP_114055472.1"
                     /transl_table=11
                     /translation="MAGTDMARFVGFKVDASDGHIGKIDRHSEYVGRQFIVVDTGPWIF
                     GRHVVVPASLVARVDEENETVHLSASRDQVKHSPEFESGRYEDDVALLQVIERYYDGHT
                     "
     gene            complement(15751..16446)
                     /locus_tag="C0216_RS13250"
                     /old_locus_tag="C0216_13230"
     CDS             complement(15751..16446)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024853.4"
                     /locus_tag="C0216_RS13250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13230"
                     /product="thioredoxin domain-containing protein"
                     /protein_id="WP_162793192.1"
                     /transl_table=11
                     /translation="MQLSRRSVLAGVGAAVIVPAAAGCLPARWGSRADEGYTGPVAAAL
                     GTEGHTVVVGDPGAPVTVRVYEDPSCPGCAEFQTEGSGPRLRRMAAEGDVQVHYVLGSF
                     LGNGSKRAVNALRASLDRGKFAELHEVLHRGQAAAKRRGGFTGGTLLSLASSVDGLRDA
                     GFDEAVRTGTHRDFVEAADRAVSTSWIKATPALEVDGRPVGKGDQDVLDDPDALDRYLR
                     RARQRSARG"
     gene            complement(16605..18161)
                     /locus_tag="C0216_RS13255"
                     /old_locus_tag="C0216_13235"
     CDS             complement(16605..18161)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265669.1"
                     /locus_tag="C0216_RS13255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13235"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_114055474.1"
                     /transl_table=11
                     /translation="MDAYGVAAAGSGAETGTEQRRGRPGREPAGSGVLVVGAGPTGLAL
                     ACDLARRGVRPLVVERSAGLFPGSRGKGIQPRTLEVFEDLGVLGAVLDRGGPAPVGMAW
                     KEGVRLGEHRMFEEVAATEQEPYAEPWLVPQWATQEVLLARLHELGGKVSFGTALTGMA
                     QDGEGVTAELAVADGATRTVRARYAVGADGGRSTVRRLTGIGMTGERVDPVPLVVADVA
                     IDSLDRDHWHLFAPAEDGSRGYAALCPLPRTGLFQFVGQYHGTRAEPAEDEVRALIAGL
                     THIRAEDVREVRWASDFTVNAALADRFREGRVFLAGDAAHIHSPAGGQGLNTSVQDAYN
                     LGWKLAAVLHDGAPEALLDTYEQERRPQAAEMLGLSTRIHRGQDRRGAATRQLGIHLRE
                     SPLSRETRTGLPEGALVAGDRAPDGRRDGIRLFDLFRGPHFTLLAVDTDLPEEVPSLPH
                     LRAARISAYAAYGRGLFLIRPDGHIAWAGRSAADAEELAGWAAWFATPVGRTAAPTPAR
                     L"
     gene            18316..19035
                     /locus_tag="C0216_RS13260"
                     /old_locus_tag="C0216_13240"
     CDS             18316..19035
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016469348.1"
                     /locus_tag="C0216_RS13260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_13240"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_114055475.1"
                     /transl_table=11
                     /translation="MTPKPDRTPPRVPPLSRATVAEAALRLLNETGLEKLTLRAIAAEL
                     DVKAPALYWHFKNKQELIDEMATEMVRRMTADDAGRKPEPAADRAGPEGGGGPGCAWRE
                     RLLAANRALRRALLSYRDGARVFSGSRFTGTDHAEHVDAQLRVLVEAGFELPQAVRTLT
                     TAFLYTLGFVTEEQGVHPVPGERREGFDVAERSARLAAHPLAAAAGPHLFEDYDAHFEE
                     GLGLILDGAAARYGIAI"
     gene            19059..19283
                     /locus_tag="C0216_RS13265"
                     /old_locus_tag="C0216_13245"
     CDS             19059..19283
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS13265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_13245"
                     /product="hypothetical protein"
                     /protein_id="WP_114055476.1"
                     /transl_table=11
                     /translation="MVIIEAADEVLPGDACGQRLLFTTLLREGRRWSSRQPQGGERSRL
                     VVTMSRDAASVPSLKERLRSHLPEAHHPG"
     misc_feature    complement(20223..20232)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 ccatcgccga caccgtccac ggcgccgacc cgcggccgcc cgtcgcaccc ccgcccgggt
       61 acgcggccac cggcgcgcgc accgctgccg cggctgcggc ggcggaccgg ccctccccgg
      121 caccggcccg tacgggcggg ccgccccgcc gccggccccc cttccccggt gtcgccgccc
      181 ccgacctcgc cctgctgcac cacgccctgc gcgaggccct ggcccggggc gtgcccggcc
      241 cgctcccgtg ggcgggggtg cgggaggcgg ccgaacggga cggcctggcc ggcgacgcac
      301 tggccggggc gctgcggtcg ctcgaagcgg cggggctgat cacggccgcc cgcggaggag
      361 ggaccgtggc gtggtgcacg ctgaccccgc acggctaccg gctcggcgcc ccgggcgcgg
      421 tacccgatct ggaggacgcc aagcgccggg tcatcgccgc gctgctgaac cggccgcccg
      481 ggcaccggtc gacgggccgg gacactgccg agctggcgga gacggccgat gccccggtcc
      541 tcgtcgcgga ccggctcctg gccgacctgg cggaggccgg gcacctgcgc ctgctccgcg
      601 gggccggcgg gcggaccctg gtggcggacg tcagccccct cctcgcccgg tggatcacct
      661 gacgcccact cagaaaccgc cgaatcgctg cagatccgcc ccgggggccg ctcgccttcc
      721 cggccacagc actaggctgg ccccggcggg cgcgggcccg ccgggggagg gggcggcagg
      781 ttgccgtacg cacggaagcg gatcttcgtc agccatgccg gaccggacct gccctgggcg
      841 gaatggatcg cctgggtgct ggagcaggag ggccacgagg tcgacctcga cctctgggac
      901 tggcggatgg gcgagcgctt cgaggagcgc gtcggcgccg gcctcggcga gcgccccggc
      961 tacgacctcg tcgtcatgct gctgtccccc caatacctcg actcccctta cgccggccgg
     1021 gaatgggagc acgcgctgcg cgccccggcg atccgcctgc tctcccccgg ccgactgctg
     1081 ccggtgcaga tcaaaccgct gaccgggccc gtgccgcccg ccctcgcccc gctcccgcgg
     1141 ctggtcctgc acggcctgca cagcgagtcc gaggtgatcg cccgcctcgc cgacgcggtg
     1201 cgcaacgccg gcgcgacggc cgggacggac gaccggaccg cccccgcccc cgcctccgcg
     1261 ccgcaacccg gcgccggccc ggtcggccgg cccgcgccct ccgccgcagc gggccccgcc
     1321 gcaccccggt tgcccggcag cgccgaccgg cccgccctgt ggaacatccc cggccgccac
     1381 cccggcgtcc agggccgcga ggccctcatc cagcagatcc gcctccaact cctcgcgtcc
     1441 tccgtggcgg ccgtcccggc gctgcacggc ctcgacgggg tcggcgcgca cgaggtcgcc
     1501 caggagtacg cgcagcgctt caggggccag tacgacctcg tgtggtggat cggcgccgcc
     1561 gaccgcgcgg cggtccgcgc cgggtacgcc gacctcgccg gccgcctcgg catcgccgcc
     1621 gcgcccggaa gccccctccg gcccgaccgc gaccggctgc tcgaagccct gttcgccgac
     1681 ctcgccaccc gccccaggtg gctcgtcgtc ctcgccgacg ccggcccccc ggaatccctg
     1741 gcagacctgc tgccgccgga gccggggcac ctgctgctgc tccccgccgc cggagactgg
     1801 acggacccgg ccgcagtacg gcggaacgtg cagcccggcc ggccggagca gcccgaggac
     1861 ccggccaccg ggcaccgtcc ggcgcagtcc ccgcccggcc cggcaggggc ccgaagccgg
     1921 ccccggccgc gcgtcctcgc agtggcgacc gagtggtcgt cctcgcgcgg cggcctcagc
     1981 accttcaacc ggcggatgtg ccgggccctg tccgtagccg gcgccgacgt gtactgcctg
     2041 gtacccgcct tcgacaagga ggaggccgcc gctgcctcgg ccgccggggt gaccctcgtc
     2101 gaggcagaac gccccccgct gtggaccggc gagcgctccc tgctgcgcaa gccgggcccc
     2161 gccctgcccg gcccgccgga cctggtcatc ggccacggcc gcgtcaccgg cccggcagcc
     2221 cagctcctgg cggaggacca ctacccgcag gcccggcgga tccacgtcat ccacatggtc
     2281 cccgaccaga tcgaatggct gaaggaggac cgcgccgacg acccggcccg ccgcgccgac
     2341 gaccgcagca ccaccgagcg cctcctcggc gccaccgcgc accggcccgt cgtcctcggc
     2401 cccctcctct acagcaagta cgccaagcac ttcaccgtcc ccacgggcgg cacccgcctg
     2461 ctgcgcgtcg accccggctt cgaaccgtcc tccgccgagc cgcgcgccgt ccccgagggc
     2521 gaccccgaag tcctcgtctt cggacgggcc gaggacgtcc tgatcaaggg cctcgacacg
     2581 gccgccgagg cgatggggcg gctcgtccgg cgcgcccacc gcttccgcgg cgtcgacctg
     2641 gccgtacgcg gcgtacccga cggtgaggac ggcggcgcgc tccgggagcg gctgatggcg
     2701 tacgcgggca gcggggacct gaacatcgtc cccaagccct tccggaccga ccccgagacc
     2761 ctgcgggccg acctgcacca cgccagcctg gtcctgctgc cgtcccggcg ggaggggttc
     2821 gggctctccg cggtcgaggc gatcgccgcg ggcacccccg tcctggtcag cgacgcgagc
     2881 gggctcggcc tgctgctgcg cgagacgctg ggcgtggcgg aggccgagca gtatgtggtg
     2941 gagacccgcg gtgacgacca ggacgcggag cggtggagcc acgccgtcga gttcctcctg
     3001 cgggaccggg cggccgcctt cgcgcgggcg gcggagctgc gcgagcacct ggcggcccgg
     3061 ttcagctgga gcagggccgc ggccgcgctc ctggccgaac tgccctgacc gggcagtccg
     3121 ggggagtagg agagcggggg cgcgcggatg ggagcggcac aggcactgga gaagctggta
     3181 ccggtggtgc tggccttcgg ctgcggggtc ctcctcgcgc ggcggaaggt cgtaccggcg
     3241 gagagctcga aggccttcgc ggactacgcc ttcctcttcg ccgtcccctg cttcctcttc
     3301 ggcaacatcc accgcagcga cctcggcgcc ctgttcgact ggcgtgccgt caccggctac
     3361 gcggccgcgg cctgcaccgg ggccgtcctc gtcggcgtcg tcgcctggac ggccggcgtg
     3421 cgcgacccgc gcggcgcggc gctgcgcatc atggccggcg tccaggtcaa cacggcctac
     3481 ttctccgtgc ccgtcttcat catgctgttc gggaacgccg cacccatctt ccccgtgctg
     3541 ctgttccagg tgtgcgtctt ctccctggtc atcatctcga tcatggagtg gggccgcccg
     3601 ggccgcgtcg gcagcccggc ccgccggctc ggatcggcgg tctccgcctc gctgctgacg
     3661 cccgtggtca tcgcctgcaa cgcgggcatc ctgctgggcc tgctgcccgt caccgtgccc
     3721 ggcgtggtcc tcgacgcgtt cgcgttcgtc ggcgacagcg cctcgcccgt cgccctgttc
     3781 gccctcggac tgcacctggg cggcagcggc ctgaagatcc gcggcaccac ccgcgaggag
     3841 atggcggtca tcgcgttcaa gtgcgccgcc atgcccctga tcacgtacgc cgtctgccgc
     3901 cacctgttcg gcgtcgaggg ggagtggctc ggccacctcg tcctgatcgc agcgatgccc
     3961 gcaccgcaga acctcttcat cttcgcccag cgctacgacg tcggcgtcga cctgtccgcc
     4021 gccctcgtcg tcaagagctc cgtcgtcgcc ctgctcctgc tcccgctgtg gacgcagtgg
     4081 gccgtacacc tggcctgagc acgaccgcac gcgccgtaca gcgcggcgaa atgccctgcc
     4141 gcgggcctgc gccacgcggc aggctcgccc ccacgccaca gcacacggcc cgccgctacg
     4201 gcagcaggtg tgccgggagg tactccggca gggccgccag cgggccggag gcggcctggt
     4261 cgaggaggtc ccggatcgga tcgcggacgg gatcgggggc cggcaccgtc ccggcaccgg
     4321 aagcggacgc ccccagccgt tccgccacgt cccggcgcag cgccggcagc agtgcgtaca
     4381 gccggtcgcc ggggcaggac gtcgcgttga agtcccggtg cccgtagatg gcggtggcgg
     4441 gcagcctgta ctgggtgcag acgtacgcgc acaggtccgc cagcgccgcg tactgcgcgg
     4501 ccggcggctc ctccgaggtg taggtgccct cgttctcgat gccgatcgac accgtgttct
     4561 ggccgacgca gtgcgccgca cggacctggc gggcgcctcc gcgcagctcg gcgaggctgc
     4621 tgtgccgccc ctccatcacg aacgcgcccc ggctcacggt gaagtgctgc ccggtgtcga
     4681 tccagccctg cgcgtccatg tggtacgtct ggatcgccct cgccagggcg aaggcccgct
     4741 gctgcgagta gtcggtgacg ttcgccgtcg ccgtgtggtg gacgatgatc cgctgagggc
     4801 ggttggcgag gaccacgacc ggctccgacg aaggccgcgc cccccaggtg gcgcagctcg
     4861 cgatgaccgg agcggccgcg tcggcggcga acgcccgtcc ggcggcgaag gaggggaggg
     4921 cggcgcccgc cgccagggcc agcgcgcccg tgaacacgga ccgcctggtg tgcgacgggg
     4981 ctgccgccgg tgcctgctgc tgcgcggaag aggtcatacc gtgcccgttt ccaatcggag
     5041 gctgcccatt gaaggggccc cgggcgtacg gggcgcgcag acacaccgcg cgcgccgccg
     5101 ccgggtgggc gcgcggccgc catccgggtg ggcgcgggcc gtgtccggcg caccgagcct
     5161 gcccgccctc cccatcctgg gcgggggccg ccccaggccc gcccgccacc gccacgccac
     5221 acaaggagta cgggatgccc ctggacgccg tcggacgctt cctggccgcc ctcgacccgg
     5281 cccaccggga cgccgtcgcc ggcgagcccc gcaaggagca ggaacggctc gccgccgcct
     5341 gggaggagga actggagtcg gacaccgaca tcgacaccct cgacgagctg tctcccgcgg
     5401 cggccgagag cgaggcggcc cggcgcgtga tggagcgccg cccccggtag cgtcctcggc
     5461 accggccgga cgcggacgcg ccccgcgccg ccccctccgg ggccgcgcgg ggcgcgcgag
     5521 gcgggcgccc gcccgtcaca tgccgagggc ccggcccaac cccgtccggt tggtccccag
     5581 cttggtgaac accgccgaca gcaactcgcc gacgaccgcg gggtccatgc gcatctcctt
     5641 gccgatcgcc gcgttgtcga ggcccagcgc cgcatgccgc gcggcctctg cctccgccac
     5701 cgtcagcgtg tcctgctcgg aggtgtgcag acggcgcggg cgcaggccgg ccgcggccag
     5761 caggccgcgc gcccggtccg tgagggtgtc cgcaccgcat gcggtggcaa cctccatgcc
     5821 ccggtacagc tgctgcgcgg cccggtgcgg atcgcccatc gtctgcagca ccgtgccgtg
     5881 gtcgacgagc gcatgcgcga actcgcacgc cgccggcgac tgctccagat gggccaccgc
     5941 ctcctccagc agtacggccg cctgcgccgg ctccacggtg gccgcctgga cgcgcagcgc
     6001 ctgcccgatg atgctcgccg ccccgaaggc acgcgcccgg gccacggcct cttccgcggt
     6061 ggcccgcgcc agtccggtgt cgtgcgtggc ctgagccagc gccaggtcga gctgccacga
     6121 actccacgac gggttccgcg taccgcgcag gtccaggcgc cggcccgctt ccgtgagctg
     6181 ccgctcggcc tcgtccacac gcccctgcgc cagcagcagc ctgccgaaca cggtctgcgg
     6241 gtccgggtag acgatggcct gcgggaagcc ctcgccgagc cggtagtcgc gcgccacctt
     6301 ctgcgcctcg gccaggttgc cgcgggcgag gagcgtctcg accagcgtgc cgaccgcgta
     6361 ccactgggcc gggttgtcct gcccgatgcg gttggcgatc tccaggccgt tgcggacgaa
     6421 gtcctccgcc tcggcgagcc ggccgcgccg gtagcggacg tagccgagca gcgtgtacac
     6481 gtaaggacag gtgcgtgccg cgccagccct tggcctcgaa ctccaggatg ccggtgttga
     6541 agagctcctc cgcccggccc ggctggtcgc agtacatgag ggtgatcgcg acgacgaccg
     6601 gcacctcgaa gccgaagtcc tggtcggtcc agctcatgcc gccgtcgagc gcctgctccg
     6661 cgaagtcgac ggcggtgccc acgggttcgc cgcgcatggc ggcgtcccag gcgcgcaggc
     6721 ccaggatgtg ccgctcggcc agaccgcggc cgacgagccg cttggcgaac tgggcgagca
     6781 gccgcgaccg ggcgggcgag ttctcctcgt cgccgcggac cgagttccac ttgaactgct
     6841 cggcctgcat gcgcagcctg gtccgggcac tggtggacct gcgcgcctcg tcgtccagca
     6901 gtccgacggc ctccgccagc cggcccgtgt gcgccagagc ctgggcaagg cggtacgtga
     6961 tcgcctcgcg cagcgccggc tcggtcttcg gctcctccag tgccgtccgc agctggttga
     7021 tggtggtcat cgggtcgtgc aggaggttcg cggcgccgag ctcgaacagc acctgcgccc
     7081 ggtcctccgg ctccgggggt tcgcgcagcg cccgcgccag gtagcggcgt gccgcgtcgg
     7141 gcgcaccggc ggcgaagctc tcgttggcgg cctggcgcag ctgctgtacg acccacgggt
     7201 cgccctcggg gtgcatctcc agtaaatgcc gcgcggcggc ggatgcgccg tgcccgccgt
     7261 cgatgagggc ctgggcggcc atgccgtgca tgccgacccg cacgccgggc gggatcgacc
     7321 ggtagacggc cgtcgcgatg agcgggtggt agaactccac gacctccttg gtgcgcagtc
     7381 cggtcaggac ggtcaggatg cgggcggccc gcagctgcga gatggcctcg gaggcctgcg
     7441 cctcgccgag ggcggcgacg cttgcgacgg tgcccgtcgg caccgcgttg cccagtaccg
     7501 cggcggccca ggcgagccgg accgtggagg ggccgagctg ctccaggcgg tcgatgaggc
     7561 cgctgccctt gacggcggac gcgaggtcgc gcagctccgg gatgttgtcc tggttcggct
     7621 tgagcccctg gtcgcggccc ttcatggcca actcgacgac ctcgaagggg tttcccgcgg
     7681 tgatcgccca gcattcgcgg cagaacatgt cgtccgcgcc ggagccgagg gcgtcgcgca
     7741 cgatgcgcgc cacagcgccg gtcgtcagcg gcgccagctc gtgcgggcgg gtgccgcggc
     7801 gcgccatgag cgcgcgcagg aacgcggcgt cggccgggat ctcgtccggc ctgcacgcca
     7861 cgatgatcag catggcgagt tcttcggccc gcgccgcgaa cgacgtgagc caggccaggg
     7921 actccgcgtc cgcccagtgc gcgtcgtcga ggacgagcac caccggcgcg ctccgcacgg
     7981 agagttgggt gacgacccag tcaaggccgt cgcggacgcc ctgcgggtcg ggtgctgtcg
     8041 ggccctgggc ggcggcggtc aggccgagcg ccggcgcgac gatgtcgtac caggcgccca
     8101 gcgattcgcg ccgctcccct tccgtcatgg ccgcgtacgc cggctggatg agctggcgca
     8161 tgacgtggaa cggaacctgc ttctcctgtt cgccgccgcg tgcgaagagc acggtgcagc
     8221 cccgctcggc ggcgtgccgc cgggcctcgg ccaacagggt ggtcttgcct atgcctgccg
     8281 atcccgcgaa ggtcaggacg cctccgcggc gggtggccga accgaggtcg gaccctccgc
     8341 acagatcgtc cacggcgcgc tggatcgcca ggatttcgga ctcccgctcg agcaggggcc
     8401 gggacgcccc tcctctgggt tcagcggcat acgacattct tgttgccccc tcctgcgcgt
     8461 gcggccgagt gtatggccct ggggggcgag atgttctcga ttcaagttgt attcccgcat
     8521 ctcgccactc gtgcgagtgc aatgctgtac cctccgctca cgacggcgcc caccggtgat
     8581 caggaattgg cgggaagccg ccccagccgg gcgcaaacga tctgtcctcg tcagcgtcgc
     8641 ggcagtggga tcaggggcag ggcgctgggc tgcggaattc cggccggcac ttcccgcacg
     8701 gtgacgccgg gggcgggtgt cagcctccac cgcgacgtga cggccgcgat cgcggtcatg
     8761 atctccgcga cgccgaacgt gtcgccgatg cacttgtgct ggcccgcccc gaacgggatg
     8821 taccggtgcg gcctcggccg tttctcggcg ccgggctgcc agcggtccgg gtcgaacacc
     8881 cggggattgc ggaagagcgc cggatcgcgg tgcagggcgt acgggctgta ggccagctcg
     8941 gcgccctcgg ggatcgcgat cccgccgagc gtgagcgggg cgagggcgcg gcgggtgaac
     9001 agcagggggg agtgcagccg cagcgcctcc tggaagacgt gccgcgtgta gccgagcgcg
     9061 ggcaggtcgg agggccggac cggccggtcg ccgacgacgg cgtcgacctc ggcctgcagc
     9121 cgctcttcga cggccgggtg gcggctgatc tcgtacaggg cccacgcgag ggtggtcgcg
     9181 gaggtctccg tgccggcgag gaggagcgag acgacctcgt cgcggacctg ctcgggcggc
     9241 atggcggcgc ccgtctcggg gtcggtgctc gacatcagca gggtgagcag gtcgtggcgc
     9301 tcctccggct ggggctcccc gtactggcgg atgacgtcgt cgatgacggc ccgcagccgc
     9361 tcggcggccg tgtcgaagcg cacgttcggc gggatgggca gccggtccag cgccttgggc
     9421 atgaccgcgc gcagcagcat gccctccagg acgacgggca gcgagcggtg cacctcgtcg
     9481 acggcggggc ggctcagctc gccggagaag accatctcgg cgaccgagga caccgcgtag
     9541 cggcgggtct cggtgaggat gcacacctct cggccgggcg cccaggaggc ggccatggcg
     9601 accgcctgcc ggctcatcgt ctcggcgtac cgggcgatgt ggttgcggtg gaaggcgggc
     9661 tggatcatcc gccgctggct gcggtggaac gcaccgtccg tcgtcacgat gccgttgccg
     9721 aagacgggcc gcagccggtc gaagatgcgt ccgcggccga actgctcggc tctgccgacc
     9781 agcacctcgt gcaccagctc ggggctggtc aggaggtgga cgggccaggt gccgatgtcg
     9841 aggcggacca cctcgccgtg gtcccggagg gactccagga aggcgatggg ctcccgccac
     9901 agggggacgg cgtggccgag gaggggtaac cgccccggcg cgaccggggc ttggactccg
     9961 gtggcttcca gtccagcgtg tgccatggcc cgaccccctg tcatgccacc gataccaggt
    10021 ccggacgggt gtaggcagac tccagcccgg ccgcgaagcg ttcgtcgcgg taccgcgtgc
    10081 actcgtaacg ctgccacaga tcggcgccga tcatccagtc ttcgcagctg tgcacgtacc
    10141 gggccacggc gtcccggagc ggggggtcgg tcgaggggtc ggcgtcgagc acctcgaaga
    10201 ggcggcggcg gccggccagg tactcctcta tgcggacctg gatgcgctgc tcgacggcgc
    10261 ggacggcgtc gggcagggag cggccctccc acgcggcgac gagggagacg aggttgttgg
    10321 tgtcgccgca ggagtgctcc ttcggcaggg agaacacgtc gttgccccac gagatgacgt
    10381 cgaggacgct cgcgacgagc tgccggagct cgcgcatctc gtggacgtac tgcggcaggt
    10441 cgaggccgag gccggcctcc accatgtcca tcatcggcag gatctgggag ctgtgccggc
    10501 gcaggaggat gtactcctcg acggtcggcc gcccgctgcc gccgcggttg ccggcctcct
    10561 ggtccagcga ggccaggacg agccggacgt gcgtgcggta gcgcgtcgcg gcgtccgggg
    10621 acagtcccgc caggatgcgg tcgcagagtt cggcgaatcc gctcaccagg gggttgcggg
    10681 cgaggtcggg gctggtgatg cggcccgtgt cgaggtattc ggtgatggcg ccgaccacgg
    10741 gccgccaggc ggcgacttcg cccttcctga tgaggtggtc gtgctggtcg tcgaggacga
    10801 acgaccaggc catccactgg gcgagcagca ggacccgctc atagggcgcg tccccgctga
    10861 cccggccggc gagatgaccg cagccgatgc ccgcgaactg gtccacggca ctcgtcacga
    10921 gttcgtggcg gaccacccac gaggtggctt ccgcgtttgc ccgcgcggcc agcgggtgct
    10981 tcgcgttgcc gaatggcagg tggaaatccg gcacggagaa attctgcagc ggtggcattt
    11041 ggctcccccc aaagacgtct gattcaccga tggtcgcccg gtcggttgcc cgggcgtcac
    11101 gacctggaac gttcctccct catgaagaat cgtcacgggg tcagggtggt gtcagtgggg
    11161 aggaaccggc cgcacggcga ctggttccgg ccatccgtaa agcaattaac acccagaagg
    11221 gcgcggagtg tcaatgtagg ccacgggaag atggtgaatt gatcccaaaa acaccacggg
    11281 gtgttcacct caaatatgtg ggcggcatag tcacggccgg ttgcacggtc cacgggaccg
    11341 gcgggacggc gcgcgcgggg gcgcacgagc ggtcgtgggc gcgggattgt ggccgaagag
    11401 cgcctggggg caagggcgtt cggcctagac ttgggaccgg gcggtaccgc ccgggagggg
    11461 tggggaagtg accgagcacc gtccgtccga tccgtaccat ccggcgtccg acggcccgga
    11521 gggcgacgta ctcggctcct acctcgaaga cctgcgggac cgcctcggcg gcgcgcggtt
    11581 cgaggcgctc atccgggccg tccaggccac ctgcgccctc ctcggcgacg gcccgcggcc
    11641 ggtgctggag gtccccggcg gcggactccc gcccgacctg cggcgcgagt acgtggccct
    11701 gctggcggtg atgatcaccg ggcgggcgga ccaccggctg gtcgaacttc cctcagccga
    11761 cggggacacg gggtgggcgg tcgtcgacgc caccgccgcg gatgcgcccg cccccggacg
    11821 cctgcacgtc cgcgcgcagc cggacggcgt cgcaggcccg gcaggccgcc tgccgacccg
    11881 ggcgcatccg catcggctcc cggggcaacg cggttaggcg cttgcccgac ctcgccgtgc
    11941 ggtgctgtac ggcgctgcac tcagcgggag ttggagccca ccgccgcgtt gcgccagacg
    12001 gtgacgtcga gggtgaggta cttgctcggc gagtcctccg gggagatgcc ccgcaccgtg
    12061 accaggccga ggtggccggt gccggtggtc acgcagacct gccggcccga gcccagctgg
    12121 ttgatcttca cgttctgcgt gaaccgggtc tcggcccggc acgtggcgag cgacccctcc
    12181 tggccggggt cgagcaggac gagcgatccg ccctgggcct ccgcgtcgag gtagctgccg
    12241 gtgtcgtacg agagctcgta gccgccgtcc tcgcccttct gcgggcggag gctctcgtcg
    12301 cccagggtca ggtggtagcc cgccacgagg ttgatgccct tgtactcggc gggctgcgga
    12361 tcgggccggg gcgctgcgcc ggacggcttg gccgccgatc ccgcgctgcc gctgccgctg
    12421 ccgctgccgt cggcgccggc gctgctgccg gcggcctggg agccgctgtc cttccccttg
    12481 accacgttgt agccgacggc gctgacggcc acggcgaagc cgatggccag ggccgccagg
    12541 acggcgccgc gcggcttgcg ctgggcgacc tgcgccggcg ggacctggaa ctggccggtg
    12601 tgcccgggat acgggtgcgc gggggtgaac tgcggtgccg tgtaggggcc ggccggctgg
    12661 tacccgtgct gcggcgggta tgcggggggt actgcggggg cgtgctgcgg cgcggccgcc
    12721 ggagtgtacg gggcgcccgc cggggaggtc gcctggtggg ccacgccgcc cggagcggtg
    12781 gactggtggg ccacgccgcc ggggacggtc ggcggatgcg ccggaggagc cggagtgatc
    12841 gccggcgccg cggcgggcgg ggcgggtgcg gcggccgggg cagcggaacg cgcggtgatc
    12901 tccgcggtca ccgcggcggg cagccagtcc tcggcccggc gcagcgtcgt ggcgtcgttc
    12961 gcggactggc acagggcgat gacctcggcc acgctcggcc ggtcggccgg atccttggcg
    13021 aggcagcggg tgacgagctc ggacagccgt tccggcaccc cggagaggtc cggctcctcg
    13081 tggacgatcc ggtacagcac cccgtgggag gcaccctcgc cgaacgccgg cgcgccggcg
    13141 gcggcgtacg cggcgacctg cccgagggcg aagacgtcgg tcgccgggcc gaccccgcgg
    13201 cccgccgcct gctccggcgc catgaaggcg ggcgtgccga cggcgacgcc gctgccggtg
    13261 agggaggtcg cgtcggcggc gtgggcgatg ccgaagtcga tgacgcgcgg gccgtcggcg
    13321 gccagcagca cgttcgacgg cttcaggtcc cggtgcacga tgccggcgcc gtggatgacc
    13381 tggagcgcct ccgcgatgcc ggcgaccagc agcagcacgg tctcgacggg cagcgccccg
    13441 tgcgcggaca cggcggcggc cagggagggg ccgggcacgt aggcggtggc cagccagggg
    13501 tgcgggccgt cggtgtcggc gtcgatgacg ggagccgtga acaggccctg cacgcgctgc
    13561 gcggagcgga tctcctgtgc gaaacgccgc ctgaactccg ggtcttcggc gaactcgggc
    13621 cggatcactt tgaccgcgac cgggcggccg cccggcgtgt gcgacaggta caccttgccc
    13681 atgccgccgg cgccgagccg ggcggcgatg cggtatcccg cgacggtggc ggggtcatcc
    13741 gggcccagcg gctcgaagtg caccggcctg ccggtgcctt ccatgccgcc gcccccgcgc
    13801 ggatgctgac cgttcatcac cttgttgctc ccaagtcctg cacgttcgat gcgcaccgca
    13861 ccctatccga gtcgggacgc ggcccgggat gccgagacgg cccatgcgat gacacgtgtc
    13921 cgacaggtcg atcggcggag cgggcgccgt gcgacgccgg ggagtccggc agctgccgcc
    13981 cctgcgtcac cctgcgttgg gatgcctgcc atacacggcc cctaacttcc tcgacgccag
    14041 cccgctcacc gctccccagc caccggcccg accgggcccg gggcgacccc ctctccgagg
    14101 agtgaccgtg gaacgtcgta ccttcctgcg cggcgccgtc gtcggcacct ccgccgcggc
    14161 cttcggcggc acgctcatgc gcggcgccgc gtacgcggcc ccggcccagc cgggcgccgg
    14221 cccctacggg gcgctcggcg cggcagacgc caacggcatc atgctgcccg ccggtttcac
    14281 gagccgggtc atcgcccggt cgggccagac cgtctccggc acctcctaca cctggcacaa
    14341 agcccctgac ggcggtgcct gctacgccga cggcaccggc tggatctacg tctccaactc
    14401 cgagatcaac ccctcgggcg gggccagcgc ggtccgtttc aactcctccg gctccatcac
    14461 ctccgcctac cggatcctct ccggcacccg gcagaactgc gcgggcggga agacgccgtg
    14521 gaacacctgg ctctcctgtg aggaggtcag cctcggctac gtgtacgaga ccgacccgtg
    14581 gggcgtgaac gcggccgtcc ggcgccccgc gatgggccgg ttcaagcacg aggcggctgc
    14641 agccgacccc gtccgccagg cggtgtacct gacggaggac gagtcggacg gctgcttcta
    14701 ccgcttcctc cccaccacct ggggcaacct ctcctccggc accctccagg tcctcaaggc
    14761 cggctcgggc acctccggct ccttcacctg gcagaacgtc ccggacccgg acggctcccc
    14821 gaccgcgacc cgcaaccagg tgtcgggcgc caagcgcttc aacggcggcg agggctgcca
    14881 ctacgccaac aacacggtct ggttcaccac caagggcgac aaccgggtct ggcagctcaa
    14941 cctctcctcc aacacctacg agctggccta cgacgactcc ctcgtcgtcg gcggcggtgc
    15001 cccgctgacg ggcgtggaca acgtcacggg ctcctccttc ggcgacctgt acgtcgccga
    15061 ggacggcggg aacatggaga tctgcgtgat cacccccgac gacgtggtcg caccgttcct
    15121 gcggatcacc ggccagtcct cgtccgagat ctgcggcccc gccttctcgc cggccggcga
    15181 ccgcctgtac ttctccagcc agcgcggcac gagcggcagc tcctccggcg gcatcaccta
    15241 cgaggtcacc ggtcccttcc gcacctgacc gccacccggg cccgcccggc ctgcgcccgc
    15301 ccgacccctc gggcagggcc gggcggaccc ggtggcatgc cgcgcccgac ccggggtagg
    15361 cgctggcacc cgaggacgtg cagggaaggg gatgcctcat ggccggtacg gacatggccc
    15421 ggttcgtcgg gttcaaggtc gatgcctccg acggccacat cggcaagatc gacaggcaca
    15481 gcgagtacgt gggccggcag ttcatcgtgg tggacaccgg gccgtggatc ttcggccggc
    15541 acgtggtggt gcccgcctcc ctcgtcgccc gcgtcgacga ggagaacgaa acggtccacc
    15601 tgtcggcctc ccgggaccag gtcaagcact cacccgagtt cgagagcggc cggtacgagg
    15661 acgacgtggc cctgctccag gtcatcgagc gctactacga cggccacacc tgagaggcgg
    15721 agccgccggc cgtgctgccg gcctccggct tcacccccgt gccgaccgct gccgtgcccg
    15781 ccgcaggtac cggtccaggg cgtccgggtc gtcgaggacg tcctggtcgc ccttgcccac
    15841 gggccgcccg tcgacctcca gggccggtgt ggccttgatc cacgaggtgc tcacggcacg
    15901 gtccgccgcc tccacgaagt cccggtgcgt gcccgtgcgc actgcctcgt cgaagcctgc
    15961 gtcgcgcagc ccgtccacgg acgaggccag cgagagcagt gtgccgccgg tgaatccgcc
    16021 gcgcctcttc gccgccgcct gcccgcggtg cagcacctcg tgcagctcgg cgaacttccc
    16081 cctgtccagg gaggcccgca gtgcgttgac cgcccgcttg gacccgttcc cgaggaacga
    16141 tcccaggacg tagtgcacct ggacgtcgcc ctcggcagcc atcctgcgca gccgcggccc
    16201 gctcccctcc gtctggaact cggcgcatcc cgggcagctc gggtcctcgt agacccggac
    16261 ggtcaccggc gcccccgggt ccccgacgac caccgtgtgc ccttccgtgc cgagcgccgc
    16321 ggccaccggc ccggtgtacc cctcgtccgc ccggctgccc caccgcgcgg gcaggcaccc
    16381 cgcggcggca ggcacgatga cggccgctcc cacaccggcg agcaccgaac gtctgctgag
    16441 ctgcacgaac attcctcccc tggtccaaag ggggaagcgt acgcagcccc ctccgacctg
    16501 cctcgcccgg ggtccggcag acatgctccg cgcggcggaa accggcggaa atccgacggg
    16561 gcgcggcggg cgcctgcaca gccgcgcggc acctgggacc ccggtcagag ccgggccggt
    16621 gtcggggcgg cggtgcggcc gacgggtgtc gcgaaccacg ccgcccagcc ggcgagctcc
    16681 tcggcgtccg ccgcggagcg gcccgcccag gcgatgtggc cgtcggggcg tatgaggaac
    16741 agtccccggc cgtaggccgc gtaggcgctg atgcgggccg cccgcaggtg cggcagcgag
    16801 ggcacctcct cgggcaggtc ggtgtcgacg gcgagcaggg tgaagtgcgg gccccggaag
    16861 aggtcgaaga gccggatgcc gtcgcgccgc ccgtcgggtg cacggtcgcc ggcgacgagg
    16921 gcgccctccg gcagcccggt ccgggtctcc cggctgagcg gcgactcccg caggtgtatg
    16981 ccgagctgcc gtgtggctgc cccgcggcgg tcctggccgc ggtggatccg ggtcgacagg
    17041 ccgagcattt cggcggcctg cggccgacgc tcctgctcgt acgtgtcgag cagggcctcg
    17101 ggggcgccgt cgtgcaggac cgcggccagc ttccagccca ggttgtaggc gtcctgcacg
    17161 ctggtgttca gcccctgccc gcctgcgggt gagtggatgt gggcggcgtc cccggcgagg
    17221 aagacccggc cctcgcggaa gcggtcggcc agcgcggcgt tgaccgtgaa gtcggaggcc
    17281 cagcggacct cgcggacgtc ctcggccctt atgtgcgtga ggccggctat cagggcgcgg
    17341 acctcgtcct ccgcgggctc ggcgcgggtc ccgtggtact ggcccacgaa ctggaagagc
    17401 ccggtgcggg ggagggggca cagggccgcg taccccctgc tgccgtcctc ggcgggcgcg
    17461 aacaggtgcc agtggtcgcg gtccaacgag tcgatcgcga cgtcggcgac gaccagcggg
    17521 acggggtcga cgcgctcccc ggtcatcccg atccccgtga gccggcggac cgtggaccgg
    17581 cctccgtcgg cgccgaccgc gtaccgggcg cgcacggtcc gagtcgcccc gtcggccacc
    17641 gccagctccg ccgtcacccc ctcaccgtcc tgtgccatgc cggtcagcgc tgtcccgaag
    17701 gacaccttgc cgcccagctc gtgcaaccgg gccagcagca cttcctgggt cgcccactgc
    17761 ggaaccagcc acggctccgc gtacggctcc tgctcggtgg ccgcgacctc ctcgaacatg
    17821 cggtgctcgc ccagccgcac cccctccttc cacgccatgc cgacgggcgc cggcccgccc
    17881 cggtcgagga ccgccccgag gacgccgagg tcttcgaaca cctccagcgt gcgcggctgg
    17941 atccccttcc cccgcgagcc cgggaacaag cctgccgagc gctcgacgac cagcggccgc
    18001 accccgcggc gcgccaggtc gcaggccagc gcgagtccgg tcggcccggc cccgacgacc
    18061 agcaccccgc tccctgccgg ttccctcccc ggccgcccac ggcgctgctc cgtcccggtc
    18121 tcggcaccgc tgcccgcggc cgccaccccg tacgcatcca tctccctgcc cccgtttccc
    18181 ttcgttccgg cgtgagcatc cgagcgcacc ctgcagcgtt tttccttaac gccgttaagg
    18241 agcgcacatc gcaagtgtgt ccttaacgtt gttaagctgt caaccccgga agcagcagcc
    18301 cgaagagagg cagcgatgac ccccaagccc gaccgcacac ccccgcgcgt cccgcccctg
    18361 agccgtgcga cggtcgccga agcggcgctg cgcctgctga acgagacggg cctggagaag
    18421 ctcaccctcc gcgccatcgc cgccgagctg gacgtcaagg ccccggcgct ctactggcac
    18481 ttcaagaaca agcaggaact catcgacgag atggcgacgg agatggtccg ccgtatgacg
    18541 gccgacgacg ccggccgcaa gccggagccc gccgcagacc gggccggccc ggagggtggc
    18601 ggcggccccg gctgcgcctg gcgcgagcgg ctcctcgccg cgaaccgcgc gctccgccgc
    18661 gcgctgctct cctaccgcga cggcgcccgc gtcttcagcg gatcgcgctt caccgggacc
    18721 gaccacgccg aacacgtcga cgcccagctc agggtcctgg tcgaagcggg cttcgagctg
    18781 ccccaggccg tccgcacgct gacgaccgcc ttcctgtaca cgctcggctt cgtcaccgag
    18841 gagcagggcg tccacccggt gccgggggag cgccgcgagg gcttcgacgt cgccgagcgc
    18901 agtgcgcgac tggccgccca ccccctggcc gctgccgccg gcccccacct gttcgaggac
    18961 tacgacgccc acttcgagga ggggctcggc ctcatcctcg acggcgcagc cgcacggtac
    19021 gggatcgcga tctgaagtgg ctgtccgcgg accaccacgt ggtgatcatc gaggccgcgg
    19081 acgaggtgct gccgggcgac gcctgcgggc agcggctgct cttcaccacc ctgttgcggg
    19141 agggacggcg atggtcctcc aggcagcccc aaggcggaga acgcagcaga ctcgtcgtga
    19201 ccatgtcgcg cgacgccgca tccgttccgt ccctgaagga acggctgcgg tctcaccttc
    19261 cggaggcgca ccacccgggg tgacccgtcc ggggctttcg agcgttcgcg gccatcgcct
    19321 cacggagccc ccgccgccct atgcacccgc gtgccccgca gggccgggga cgtcggcggc
    19381 gtcgccggag gccgccgctc ccgccgtgtc cacggcggac gcggccgccg caaggtcccc
    19441 gtcgccctcc ccgaggtccg ggatctgctg ctccgaccag atgaccttcc cctcgggcgt
    19501 gtaccgggcc ccccaccgcc ggctcagctg ggcgacgagg aacagcccgc ggcctccctc
    19561 gtccgtcgtc gtcgcgtagt gcaggcgcgg ggagctgctg ctgccgtcga agacctcgca
    19621 ggtcagcacc cgatcccgca ggaggcgtac gcggaccggc tcggcgccgt gccggatcgc
    19681 gttcgtgatc agctcgctga gcaccagctc cgtgccgaac accagctcct ccaggcccca
    19741 ctcctccagc ttcgcggtcg cggcggcgcg aagctgcccc accgcgctcg gctcgaacgg
    19801 cacgtcccat tcggcgatcc ggtcggccga cagggccgac gtacgggcga cgagcagggc
    19861 gacatcgtcg cgggcccgca ccggcagcag ctcggcgagg accgcccgca cggtgtcctc
    19921 cgggctcggg ccggcacgcg agagggcggc gcgcagcagg tcgagccctt cgtcgatgtc
    19981 ccgggtgcgg tcctcgatca gcccgtccgt gtacaggacc agtcggctcc cctcggccag
    20041 gtccagttcg gccgactcga acgggaaccc gcccaggccc agcggcgcgc cggccggcag
    20101 ctccggcgcc tccaccgtgc cgtcggcgtg taccacgaga ggcgggacgt gccccgcgcg
    20161 cgccaccgtg cagcgccgcg ccaccgcgtc gtagacggcg tacaggcagg tggcgccgag
    20221 gaggccgcct tcggcgcctc cgccctcgcc gttctggtcg gtgtactgca cgaggtcgtc
    20281 gaggcgggcg agcagctcgt cgggcggcag gtccaaggag gagaagttca ggacggcggt
    20341 gcggagccgg cccatggcgg ccgcggcgtg caggccgtgc ccgacgacgt cgccgacgac
    20401 gagcgcgacc cgcccggcag gcagcgggat cacgtcgaac cagtcgccgc ccacccccga
    20461 ctgcgcgggc aggtagtaat gggccacttc cacggcgctc tgctccggca ggtcccgggg
    20521 cagcaggctg tgctggagag tgatcgccac ggcgtgctcg cgggtgtagc ggcgggcgtt
    20581 gtcgatgctg acgccggccc gggccaccag ctcctccgcc agcgacaggt cctcctcgtc
    20641 gaacggctcc ggcttctcgg agcgccagaa gttgaccacg ccgaggacca ccccgcgggc
    20701 cttgaggggc gccgtgatca gcgagtggat gccgtagtcg atgacggcct gggcccgcgg
    20761 cgggtcctgc gcgtaccagc cgggtgcctt cttcaggttg gcgatgacct cggccctgcc
    20821 gctgctcagg ccccgtgcct gcggcgtgga cggcagaaag tcgatcaccc ggccgcgcgg
    20881 gtagagcggg atgtcctcgc ggatgccgct gacgccggtg cggcgcaggt cgcccggtgc
    20941 ggcggtgggc tcgtcgcccc gcaggaccgg ttccgccagg tcgacggtcg cgaagtcggc
    21001 gaaccgcggc acgg
//
