LOCUS       NZ_CP030862            22220 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces globosus strain LZH-48 chromosome, complete genome.
ACCESSION   NZ_CP030862
VERSION     NZ_CP030862.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globosus
  ORGANISM  Streptomyces globosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Draft genome Sequence of streptomyces globosus LZH-48
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Institute of Biophysics, Dezhou University,
            566 DaXuexi RD, Dezhou, Shandong 253023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Portal v. version 2.2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003325375.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:22:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,671
            CDSs (total)                      :: 6,576
            Genes (coding)                    :: 6,458
            CDSs (with protein)               :: 6,458
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 41 of 118
            Pseudo Genes (incomplete)         :: 101 of 118
            Pseudo Genes (internal stop)      :: 11 of 118
            Pseudo Genes (multiple problems)  :: 32 of 118
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:39:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2058097
            Orig. end                         :: 2080317
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030862.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22220
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="9"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22220
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22220
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12220](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12220)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    544..557
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(721..737)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.87"
                     /tool="antismash"
     misc_feature    complement(873..887)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     misc_feature    1159..1177
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.35"
                     /tool="antismash"
     misc_feature    complement(1421..1437)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.96"
                     /tool="antismash"
     misc_feature    complement(1514..1531)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.45"
                     /tool="antismash"
     misc_feature    complement(1525..1542)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.73"
                     /tool="antismash"
     gene            1610..2503
                     /locus_tag="C0216_RS09465"
                     /old_locus_tag="C0216_09460"
     CDS             1610..2503
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965395.1"
                     /locus_tag="C0216_RS09465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09460"
                     /product="xanthine dehydrogenase family protein subunit M"
                     /protein_id="WP_114054835.1"
                     /transl_table=11
                     /translation="MDFLRPAGWEEALAAKAEYPTAVPIAGGTDIMVEINFDHRRPEYL
                     LDLNRIELLREWEVGEEVTRVGASVPYTHIMENLRETLPGLALASHTVASPQIRNRGGV
                     GGNLGCASPAGDSHPALLAAGAEVEVESVRGTRMIPIDEFYTGVKRNALAPDELIKAIH
                     VKNATGPQQYSKVGTRNAMVIAVCAFGLALHPETRTVRTGIGSAAPTPIRAKAAEEFLN
                     AALEEGGFWDSGKVITPSIAKQFGELASGACNPIDDVRGTAKYRRHAVGIMARRQLVWT
                     WEQYRGSNGRPLEGAA"
     gene            2506..3111
                     /locus_tag="C0216_RS09470"
                     /old_locus_tag="C0216_09465"
     CDS             2506..3111
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944663.1"
                     /locus_tag="C0216_RS09470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09465"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_114054836.1"
                     /transl_table=11
                     /translation="MRVNFTVNGRPQQADDVWEGESLLYVLRERLGLPGSKNACEQGEC
                     GSCTVRLDGVPVCSCLVAAGQVEGRDVVTVEGLADFARKRGEHGHGGACGTGACGGAAG
                     VSTDEAQRWSAKGTDSQTGEGVELSGIQQAFIDAGAVQCGFCTPGLLVQADALLEQNPD
                     PTDQDIREALSGNLCRCTGYEKILDAVRLAAARQGEAV"
     misc_feature    2507..2521
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.09"
                     /tool="antismash"
     misc_feature    2513..2527
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.56"
                     /tool="antismash"
     gene            3114..5516
                     /gene="pucD"
                     /locus_tag="C0216_RS09475"
                     /old_locus_tag="C0216_09470"
     CDS             3114..5516
                     /EC_number="1.17.1.4"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pucD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1293: aldehyde oxidase and xanthine dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267276.1"
                     /locus_tag="C0216_RS09475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09470"
                     /product="xanthine dehydrogenase subunit D"
                     /protein_id="WP_114054837.1"
                     /transl_table=11
                     /translation="MANTRTTPSGTPTNVSQKHSQGGIGESTLRPDGTLKVTGEFAYSS
                     DMWHEDMLWGQTLRSPVAHAEIAGIDISEALALPGVYSVLTYADLPTEVKNYGLEIQDT
                     PVLANGRVRHHGEPVALVAADHPETARRAAAKIKVDYRELPLVTDEASALAPGAPLLHE
                     GRDDHHAGHVPHPNIVHRQPIVRGNVEEARKRADVIVEGEYTFGMQDQAFLGPESGLAV
                     PGEDGGVDLYVATQWLHSDLRQIAPVLGLPEEKVRMTLSGVGGAFGGREDISMQIHACL
                     LALATNKPVKMVYNRFESFFGHVHRHPAKLYYEHGATKDGKLTHMKCRIVLDGGAYASA
                     SPAVVGNASSLSVGPYVVDDVDIEAIALYTNNPPCGAMRGFGAVQACFAYEAQMDRLAA
                     KLGMDPVEFRQLNAMEQGTVMPTGQVVDSPAPVAELLRRVKARPLPPERQWETAGEGAD
                     VRALPGGLSNTTHGEGVVRGVGYAVGIKNVGFSEGFDDYSTARVRLEVIGGEAVAMVHT
                     AMAEVGQGGVTVHAQIARTELGVTHVTIHPADTQVGSAGSTSASRQTYMTGGAVKNTCE
                     AVREKVLEIGRRKNGSYHPAWATAELLLEGGKVVTDGGEVLADIAELLEGEEPIDLELE
                     FRHRPTAAFDLVTGQGDGHVQYTFAAHRAVVEVDTELGLVKVVELACAQDVGKALNPLS
                     VIGQIQGGTTQGLGVAVMEEIIVDPKTAKVRNPSFTDYLIPTILDTPSIPVDYLELADP
                     NAPYGLRGLGEAPTLSSTPAVLAAIRAATGLELTKTPIRPEALTGTL"
     gene            5879..7345
                     /locus_tag="C0216_RS09480"
                     /old_locus_tag="C0216_09475"
     CDS             5879..7345
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125408.1"
                     /locus_tag="C0216_RS09480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09475"
                     /product="NCS2 family permease"
                     /protein_id="WP_114054838.1"
                     /transl_table=11
                     /translation="MTQSSVEPKTTAEEAGDGSRTPAGRSWLDRYFHITHRGSSVGNEI
                     RGGVTTFMAMAYILLLNPLILSGKDAAGDTMSQKALITATAFAAAVTTLLMGFVGKVPL
                     ALAAGLSVSGVLASQVAPQMTWPQAMGMCVMYGVVICLLVVTGLREMIMNAIPLALKHA
                     ITMGIGLFVALIGLVKAGFVHENPAPGGGPVTLGPTGELAGWPVLLFSVTLLLIFMLQA
                     RKVPGAILIGIGVGTVLAVVLNAIADVDPKAWASGPPELNGSAVSLPDFSLFGEVEFGG
                     WGEVGAMTVGMIVFTLVLAGFFDAMATIIGVGTEAKLADDKGRMPGLSKALFIDGAGGA
                     IGGVAGGSGQTVFVESATGVGEGARTGLASVVTGLFFALCIFFTPITQIVPGEVASAAL
                     VVIGAMMMQNARHVDWADAATAVPVFLTVVIMPFTYTITAGVAAGVISHVAIKVAQGKA
                     REIGAFMWALTAIFVVFFALDPIEGWLGVH"
     gene            7412..8590
                     /locus_tag="C0216_RS09485"
                     /old_locus_tag="C0216_09480"
     CDS             7412..8590
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385643.1"
                     /locus_tag="C0216_RS09485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09480"
                     /product="XdhC/CoxI family protein"
                     /protein_id="WP_114054839.1"
                     /transl_table=11
                     /translation="MLDIAEELNRWVEQGRDFAVATVVAVTGSAPRQPGAALAVDEAGT
                     AVGSVSGGCVEGAVYDLCVQALQDGETVLERFGYSDDDAFAVGLTCGGIIDILVTPVRA
                     GTPGRQVYEAALAAAARGGAAAVARIAEGPQELKGSAVLVLGEDGEDREDRGDRFLGGF
                     GGHPELDRMVAEEARALLDAGKTGVLEVGADGRLCGEPLKVLVESSVPPPRMIVFGAID
                     FASALVRIGKFLGYHVTLCDARPVFATKQRFPEADEIAVDWPHRYLERTETDGRTVLCV
                     LTHDAKFDVPLLRLALRLPVAYVGAMGSRRTHEDRNRRLRDVGVTELELARLRSPIGLD
                     LGARSPEETALSIAAEIVANRRGGSGAALTGAHIPIHPDAPATAARRIGSVA"
     misc_feature    complement(8655..8672)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.65"
                     /tool="antismash"
     gene            8698..9993
                     /locus_tag="C0216_RS09490"
                     /old_locus_tag="C0216_09485"
     CDS             8698..9993
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031550.1"
                     /locus_tag="C0216_RS09490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09485"
                     /product="YncE family protein"
                     /protein_id="WP_114054840.1"
                     /transl_table=11
                     /translation="MPRTARTARTPVRTLLAGGVLAAAALAAAAAPAPAAPPAPASARP
                     AAPDAAGLREVLFVGNNWEGTADVLASTGGMERIGRINVVPDKEERLREIHLNPVKLAF
                     FLGIRHSAGEGHDQLVDDMYTTPDGSAVVVSRPSFADVVSLDLRTGRINWRFPVSGYRS
                     DHMAVSPDGTRVAVSASTSNTVHVLDIATGRQVGSFATGDKPHENTFSRDGRLIWNASI
                     GEVNTALDAPWLDWTKGDRKFTVVDAQTFRTVRTVDMRERLDAAGRSDLSDSIRPNAFT
                     PDESMLYFQVSFFNGFAEYDVAADRITRVKTLPKNPKTPADRMAWVNDSRHHGMAMSPD
                     GAKLCIAGTMDDYATVVDRATLAEGPLVPADKPYWATVSGDGTACVISESGSDRVTAID
                     FATGEKRVSVPVGDHPQRVRLGRVPADWTGTR"
     gene            complement(10001..12220)
                     /locus_tag="C0216_RS09495"
                     /old_locus_tag="C0216_09490"
     CDS             complement(10001..12220)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321403.1"
                     /locus_tag="C0216_RS09495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09490"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_114054841.1"
                     /sec_met_domain="T1TS (E-value: 2.6e-81, bitscore: 272.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFRLPDFYVPYPARLNPHLEAAREHTRRWARGFGMLEGSGVW
                     TQEDLDAHDYALLCSYTHPDCGADALELVTDWYVWVFFFDDHFLEVYKRSGDREGARAY
                     LDGLAAFMPMDLADGFPEPANPVEAGLRDLWQRTVPAMSAAWRERFAESTRNLLNESMW
                     ELHNIGMGRVANPLEYIEMRRKVGGAPWSAGLVEYVAAEVPARVAHARPLQVLRDAFSD
                     AVHIRNDIFSYRREVEEEGELSNAVLVLETFLDCTTQEAADLANDLLTSRLEQFEYTAL
                     AEVPALAARHGLGPDEAAAVLAYAKGLQDWQSGGHEWHMASSRYMNEEARRSAPRTLPF
                     LPGGLGTAALDWRSVLTPRSLELRRRRFSHVPFRKVGRRILPDIDLPFALSLNPHLDRA
                     RRELTAWCRVVGMLEPQPGDPGSDVWTEDVLAGMDLALCAAGIDPDAAPEALSLGAQWL
                     AWGTYGDDYYPRVFGAARDPGGARAAADRLAAMMPPEPGQGPEPLTALERGLADLWART
                     AAGLDGQARAGFRRHVVAMLDSWVWEIANTAVNRVPDPVDYAEMRRFTFGSDLTMFLAR
                     LGRGDGTAFPEELRREGAVRSLESAAADVGCLVNDLFSYRKEIEFEGEVHNHVLVAQHF
                     FGIDYPQAAAIVADLLAQRTREFEHVRDHQLPVLCDDRGLGAAERAALASYVRELEDWM
                     AAILHWHRSVRRYRDEELRPGPAGLRALLAGPGFGMAAARISLPS"
     gene            complement(12419..16036)
                     /gene="cobN"
                     /locus_tag="C0216_RS09500"
                     /old_locus_tag="C0216_09495"
     CDS             complement(12419..16036)
                     /EC_number="6.6.1.2"
                     /GO_function="GO:0051116 - cobaltochelatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cobN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1263: cobaltochelatase subunit CobN"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993582.1"
                     /locus_tag="C0216_RS09500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09495"
                     /product="cobaltochelatase subunit CobN"
                     /protein_id="WP_114054842.1"
                     /transl_table=11
                     /translation="MILLLSTSDTDLLSARAAGGPVPYRFANPSRLPLDDLPGLLDGAD
                     LVVVRLLGGLRAWEDGLEALLDREQTRPVVVLTGEQAPDAQLMEASTVPIGIAAEAHAY
                     LAHGGPDNLEQLARFLSDTVLLTGHGFEPPAAAPTWGPLERPDAPSAAADGPRIAVLYY
                     RAHQMSGNTAFVHALCDAITAAGGSPVPLYVSSLRTPEPELLAALEGADAVVTTVLAAG
                     GTRPATASAGGDDESWDAGALARLGVPVLQALCLTGSRSAWEENDEGLSPLDAATQVAV
                     PEFDGRLITVPFSFKEFDADGLPAYVADPERAARVAGIAVRHARLRHIARADKKIALVL
                     SAYPTKHSRIGNAVGLDTPASAVRLLRALIDGGYDFGPAEDIPGLVSGDGDELIRALIE
                     AGGHDQDWLTEEQLARNPVRIPAADYRRWYAELPAELREQVEEHWGEAPGSMFVDRSAN
                     PEGDIVLAALRRGNLLILIQPPRGFGENPIAIYHDPDLPPSHHYLAAYRWIQAAAEDGG
                     FGADAMIHLGKHGNLEWLPGKNAGLSAACAPDAALGDLPLVYPFLVNDPGEGTQAKRRV
                     HATLVDHLVPPMARAESYGDIARLEQHLDEYAQISAMDPAKLPAIRAQIWTLIQAAKLD
                     HDLGLEERPDDDGFDDFLLHVDGWLCEVKDAQIRDGLHVLGGAPAGEARVNLVLAILRA
                     RQIWGGTTALPGLREALGLDESKATRTSADEAEEAARGLVQAMEDAGWDPAAVSRVAAG
                     HPEQVAAVLDFAAREVVPRLAGTTDEIAHVVAALDGRFVPAGPSGSPLRGLVNVLPTGR
                     NFYSVDPKAVPSRLAWETGQALAESLLERYRTDNGEWPASVGLSLWGTSAMRTAGDDVA
                     EALALLGVRPVWDEASRRVTSLEAIPPAELGRPRVDVTLRISGFFRDAFPHVIGLLDDA
                     VRLVAALDEPAEQNFVRAHAQADLAEHGDERRATTRIFGSRPGTYGAGILQLIDSRDWR
                     TDADLAEVYTVWGGYAYGRGLEGRPARAEMESAYKRITVAAKNTDTREHDIADSDDYFQ
                     YHGGMVATVRALRGTAPEAYIGDSTRPETVKTRTLVEETSRVFRARVVNPRWIEAMRRH
                     GYKGAFELAATVDYLFGYDATTGVVADWMYDKLTETYVLDPENRAFLEEANPWALHGIA
                     ERLLEAESRGMWEKPDPQVLEALRQVYLDTEGNLESDGG"
     regulatory      complement(16090..16174)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            16326..17672
                     /gene="cobG"
                     /locus_tag="C0216_RS09505"
                     /old_locus_tag="C0216_09500"
     CDS             16326..17672
                     /EC_number="1.14.13.83"
                     /GO_function="GO:0016709 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, NAD(P)H as one donor, and incorporation
                     of one atom of oxygen [Evidence IEA]"
                     /GO_process="GO:0019250 - aerobic cobalamin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="cobG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004938317.1"
                     /locus_tag="C0216_RS09505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09500"
                     /product="precorrin-3B synthase"
                     /protein_id="WP_246042431.1"
                     /transl_table=11
                     /translation="MPQPPSAVSRDEPVIRDRGDACPGALRLHAADDGFLARIRIPGGI
                     LGADAARLLADAADRLGDGHIDLTSRGNAQLRGLGASCGGELAAVLERAGLLPAPGHER
                     VRNVVASPLTGLDGRGRADVAPWVARLDRELCAEPAAAALSGRFLFAVDDGRGDVLSLS
                     ADANVLACGGGQALLWLGPGGPDSRAARVAADDAPRAAVAAALCFLDAARAAGTRAWRV
                     AELPPEHRPDAAGLAARLAAAGIPAEVVPLDAPQGPGGPEPLPGVVRGTSGGPAALSVL
                     APLGRLDTAQWRLLAGLSGRMRLTPWRGVVVPGLAAGAADSALAALARAGLATAPDSPW
                     RSVTACTGRPGCAKALADVRADARAVAARATGPLPVHWSGCERRCGHPRGTAWVDLVAT
                     GDGYAVTLAAAGTAGPAHRTVKTSELAAVLADARRTDACRTPSHDAAKK"
     gene            17669..18316
                     /locus_tag="C0216_RS09510"
                     /old_locus_tag="C0216_09505"
     CDS             17669..18316
                     /EC_number="5.4.99.61"
                     /GO_function="GO:0016993 - precorrin-8X methylmutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014056941.1"
                     /locus_tag="C0216_RS09510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09505"
                     /product="precorrin-8X methylmutase"
                     /protein_id="WP_114054844.1"
                     /transl_table=11
                     /translation="MSEYTVFEYEKDGAEIYRQSFATIRAEADLSGLPASVAQVAVRMI
                     HACGMTDLPQDLGYTPDVVLRARAALHAGAPILCDVQMVASGVTRKRLPADNQVVCTLS
                     DPAVPALAARMGTTRSAAALEVWRDRGLLEGSVVAVGNAPTALFRLLEMIEEGAPRPAA
                     VIGVPVGFIGAAESKDALAAHPSNLDHLVVRGRRGGSALAAAALNAIASEEE"
     gene            18313..19860
                     /locus_tag="C0216_RS09515"
                     /old_locus_tag="C0216_09510"
     CDS             18313..19860
                     /EC_number="2.1.1.130"
                     /GO_function="GO:0030788 - precorrin-2
                     C20-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125855.1"
                     /locus_tag="C0216_RS09515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09510"
                     /product="precorrin-2 C(20)-methyltransferase"
                     /protein_id="WP_114054845.1"
                     /sec_met_domain="TP_methylase (E-value: 8.5e-52, bitscore:
                     174.6, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTAATPAATPAAAGSAAAPAKGRLYGVGLGPGDPSLMTLRAVE
                     AIAEADVVAYHSARHGRSIARSIAARHLRADHIEEPLVYPVTTETTDHPGGYQGAMEEF
                     YEASAARLAAHLDAGRTVAVLAEGDPLFYGSYMHMHKRLADRYEAEVIPGVTSVSAAAA
                     RLGTPLVEGEEVLTVLPGTLPEEELAARLAATDSAVVMKLGRTFPAVRRALETSGRLAE
                     ARYVERATMDGERTGLLADTDPDTVPYFSVAVVPSRVGNPGSVPSGPGEVAVVGTGPAG
                     PLWLTPETRRALSDAEVLVGYTTYLDRVPARPGQIRHGSDNKVEAERAEFALDLARRGK
                     RVAVVSGGDPGVFAMATAVLEAAAQDAYKDVPVRVLPGVTAANAAAAAAGAPLGHDYAT
                     VSLSDRLKPWEVIAERLRAAAAADLVLALYNPGSRSRTWQVAKARDLLLELRSPHTPVV
                     VARDVGGPEQSVRVVTLETLEPSEVDMRTILLIGSSQTQVTERPDGTSVAWTPRRYP"
     gene            complement(19922..20710)
                     /locus_tag="C0216_RS09520"
                     /old_locus_tag="C0216_09515"
     CDS             complement(19922..20710)
                     /EC_number="1.3.1.106"
                     /GO_function="GO:0016994 - precorrin-6A reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018890779.1"
                     /locus_tag="C0216_RS09520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09515"
                     /product="cobalt-precorrin-6A reductase"
                     /protein_id="WP_114054846.1"
                     /transl_table=11
                     /translation="MSAEAGSGPHVLVLGGTTEARRLAELLAEGAADAAGRPWRVTTSL
                     AGRVAAPVLPPGGVRIGGFGGPEGLAAWIAAHAVTHLVDATHPFAERMSFNAAAAARLA
                     GVPLLALRRPGWSPGPGDDWTFAADLAEAASLLPGLGSRVFLTTGRTGLHAFAHLADPW
                     FLVRSVDPPAAPAPPRLEVLLARGPFSLDDERALLARHRIDVLVTKDSGGQATAPKLAA
                     AREAGVPVLVVRRPPVPAGVPEAGTAAAAARWLHGPAGRS"
     gene            complement(20700..21449)
                     /gene="cobM"
                     /locus_tag="C0216_RS09525"
                     /old_locus_tag="C0216_09520"
     CDS             complement(20700..21449)
                     /EC_number="2.1.1.133"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0046026 - precorrin-4
                     C11-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cobM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019887972.1"
                     /locus_tag="C0216_RS09525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09520"
                     /product="precorrin-4 C(11)-methyltransferase"
                     /protein_id="WP_114054847.1"
                     /sec_met_domain="TP_methylase (E-value: 2.7e-41, bitscore:
                     140.3, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVYFIGAGPGAADLITVRGARTLAAAPVCLYAGSLVPRELLAEC
                     PDGARLVDTSRLNLDEIIAECVRAHEAGLDVARLHSGDPSVFSAVAEQMRRLDAAGIPY
                     EVVPGVPAFAAAAAALKRELTVPTVGQTVILTRIAQQATPMPPGEDLATLGRSGALLVL
                     HLATRYVDRVVEELLPHYGAECPAAVVAMASRPDELVLRGTLADIAGQVKEAGLVRTSV
                     IIVGRTLGAEQFRDSHLYSPERDRHVC"
     misc_feature    complement(21538..21553)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.37"
                     /tool="antismash"
     misc_feature    21674..21689
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     misc_feature    21933..21946
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
ORIGIN
        1 gggcgcgcgg cggcgacccg ccgggcgtgc cgggcctcct ccagcgcgcc gcgcagcccc
       61 tcggcggagt gcacggcggc gctgacgccg agggtgaggc ggccgtcgtc ggcgaggccc
      121 gcgcgcaggg gctcccgtac ggtcgcgagg agctcgtcgg cgtgcagggc ggcctgcggg
      181 gccttgtcct ccgcgccctc cccggtctgc gcgggcagcg gcacgagggc gatggcctcg
      241 tcgccggtgt gggcgaccgc gatgcggtcc gagggctccg gcccggacac ggacgggtcg
      301 acgaggatct cctccagcag cgactgcgcc accggcccgc cggggatgtc gccgccctcc
      361 cagtccaccc gggccacgac gacctgccag tgcggggccg cgccgagccc cggcagcagc
      421 accggggccg cgacgcgcag gcgcgcggcg atctcggcgg gcggggcgcc cgtctggacg
      481 agctccagca cctcctgggc caggcggcgg cgcaccgtgc gggcggcgtc gcgccggtcc
      541 cgctcgacgg cgatcagctg ggtgacgccc tggagcaggt cgagccgctc cgccggccag
      601 tcgcccgcgt cggcctcgac ggccagcagc cagtccgaca gcacgctctc gcgcacgtcg
      661 cggccgcccg ggccgcccgg ggcgcggccc gctcccctga tcgggaacag cgagtaggca
      721 ataccctgga gggagatccg gtgcgggccc ctgcgcccgg tgcggaccgc cgcgaggtgc
      781 tcgccggcca gggccgcaca gatgcccggc ggcaggggct ctcccgctcc ggcgatctgc
      841 cggcccgtgg gggagagcac ccacgcgcgc agatcgaggt cggtggtgag cagatcgagc
      901 accacgtcgg gaccgccgcc cgcgggaccg gaggtcatca gccggcggtg gcggtcgacg
      961 acggccgcga ggtcgccggc gcgctcgccg gagacctgcc gcaccacgta ctccgtgatg
     1021 gtggcgaatg caacgtcctc gttcaccgcg aacagcggga gccggtggtg ccggcaggcg
     1081 gcgacgaggt cgtcggggat gtcgcccagc tccgcctcgc ccgcggcgag gccggcgacg
     1141 cccgcgctcg cgaggattcg tacgaacggc tcggagtcgg ctgaatttct tcgccacgcc
     1201 aggcccgtca ggacgagttc gcccccggtg aggtaccggc tgggatccct caggtccgtc
     1261 gtcatgacgc cgcggaccgt ccggtcgagt tcgtcctcgc cgcccagcag ccgcagcccc
     1321 agcgcctcgg tttccagcag tgcgcgcagc cgcatggtgt cgccgccgat ctgtctcgaa
     1381 tgttgccgtc ggaaatcggg caggtcagtg catcctgcct ttcatacgaa tctacaagac
     1441 gagggaggcc gccagccaac tccttcatgg tttcggtgac tgcaccgcag ggacgcgcgg
     1501 cttgtgtact gactccacac cgcgttaaca gcaagtgaac gaccagtcga gggcccttcg
     1561 gcctcctggc ccccaagcga acgacccgat tacaagaaga gagccgcaca tggacttcct
     1621 tcgccccgcc ggctgggagg aggcactcgc cgccaaggcc gagtacccca cagccgtgcc
     1681 gattgcgggt ggcaccgaca tcatggtcga gatcaacttc gaccaccgcc gtccggagta
     1741 cctcctcgac ctgaaccgca tcgaactgct gcgggagtgg gaggtaggcg aggaggtcac
     1801 cagggtcggc gcctccgtcc cgtacacgca catcatggag aacctgcgcg agacgctccc
     1861 cgggctcgcg ctcgcctcgc acacggtcgc ctccccgcag atccgcaacc gcggcggcgt
     1921 cggcggcaac ctgggctgcg cctctcccgc gggcgactcc caccccgccc tcctcgccgc
     1981 cggcgccgag gtcgaggtcg agtccgtccg cggcacccgc atgattccga tcgacgagtt
     2041 ctacaccggc gtcaagcgca acgcgctcgc ccccgacgag ctcatcaagg cgatccacgt
     2101 caagaacgcc accggtccgc agcagtactc caaggtcggc acccgcaacg cgatggtcat
     2161 cgccgtgtgc gccttcggcc tcgcgctgca ccccgagacc cgcaccgtgc ggacgggcat
     2221 cggctcggcc gcgcccacgc ccatccgggc gaaggccgcc gaggagttcc tgaacgccgc
     2281 ccttgaggag ggcggcttct gggacagcgg caaggtcatc accccgtcga tcgccaagca
     2341 gttcggtgag ctcgcctccg gcgcctgcaa cccgatcgac gacgtccgcg gcacggcgaa
     2401 gtaccgccgg cacgcggtcg gcatcatggc tcgccgccag ctcgtctgga cgtgggagca
     2461 gtaccgcggc tcgaacggcc gcccgctcga aggggctgcg taaccatgcg cgtcaatttc
     2521 actgtcaacg gtcgtccgca gcaggccgac gacgtctggg agggcgagtc cctcctgtac
     2581 gtcctgcgtg agcgcctggg cctgcccggc tcgaagaacg cctgcgagca gggcgagtgc
     2641 ggatcctgca ccgtacgcct cgacggcgtg cccgtctgct cctgtctcgt cgccgccggc
     2701 caggtcgagg gccgcgacgt cgtgaccgtc gagggcctgg ccgacttcgc ccgcaagcgc
     2761 ggggagcacg gccacggcgg ggcctgcggc accggcgcct gcggcggcgc ggccggcgtg
     2821 tccacggacg aggcgcagcg ctggtccgcg aagggcaccg actcgcagac cggcgagggc
     2881 gtggagctgt ccggcatcca gcaggcgttc atcgacgccg gcgccgtcca gtgcggcttc
     2941 tgcaccccgg gcctgctggt ccaggccgac gccctgctgg agcagaaccc ggacccgacc
     3001 gaccaggaca tccgcgaggc cctgtccggc aacctctgcc gctgcacggg ctacgagaag
     3061 atcctcgacg cggtccgcct ggcggccgcc cgccagggag aggcggtctg accatggcca
     3121 acacccgcac cactccgtcc ggcacgccga cgaacgtctc ccagaagcac agccagggcg
     3181 gcatcggcga gtccacgctc cgccccgacg gcaccctcaa ggtcaccggc gagttcgcgt
     3241 actcctccga catgtggcac gaggacatgc tgtggggcca gaccctgcgc agccccgtcg
     3301 cgcacgccga gatcgccggc atcgacatct ccgaggcgct ggccctgccc ggcgtctact
     3361 cggtcctcac ctacgcggac ctgccgaccg aggtgaagaa ctacggcctg gagatccagg
     3421 acacccccgt cctcgccaac ggccgggtac gccaccacgg cgagccggtc gccctcgtcg
     3481 ccgccgacca cccggagacg gcccgccggg ccgccgccaa gatcaaggtg gactaccggg
     3541 agctgccgct cgtcaccgac gaggcctccg ccctcgcccc cggcgcgccg ctcctccacg
     3601 agggccgcga cgaccaccac gccgggcacg tcccgcaccc gaacatcgtg caccgccagc
     3661 ccatcgtccg cggcaacgtg gaggaggccc gcaagcgcgc cgacgtcatc gtcgagggcg
     3721 agtacacctt cggcatgcag gatcaggcgt tcctcggccc cgagtccggc ctcgccgtac
     3781 ccggggagga cggcggcgtc gacctgtacg tcgccaccca gtggctgcac tccgacctcc
     3841 ggcagatcgc ccccgtcctc ggcctgcccg aggagaaggt ccgcatgacg ctgtccggcg
     3901 tcggcggcgc cttcggcggc cgcgaggaca tctccatgca gatccacgcc tgcctgctcg
     3961 ccctcgccac gaacaagccg gtcaagatgg tctacaaccg gttcgagtcc ttcttcggcc
     4021 acgtgcaccg ccacccggcc aagctgtact acgagcacgg cgccaccaag gacggcaagc
     4081 tcacgcacat gaagtgccgg atcgtcctgg acggcggcgc ctacgcgtcg gcctccccgg
     4141 ccgtcgtcgg caacgcctcc tcgctctccg tcggcccgta cgtcgtcgac gacgtcgaca
     4201 tcgaggccat cgccctctac acgaacaacc cgccctgcgg tgccatgcgc ggcttcggcg
     4261 ccgtccaggc ctgcttcgcg tacgaggccc agatggaccg gctcgcggcg aagctgggca
     4321 tggacccggt cgagttccgg cagctcaacg ccatggagca gggcacggtc atgccgaccg
     4381 ggcaggtcgt ggactccccg gccccggtcg ccgagctgct gcgccgggtc aaggcccgcc
     4441 cgctgccgcc ggagcgccag tgggagaccg ccggcgaggg cgcggacgtc cgcgcgctgc
     4501 ccggcggcct gtcgaacacc acccacggcg agggcgtcgt ccgcggcgtc ggctacgcgg
     4561 tcggcatcaa gaacgtcggc ttctccgagg gcttcgacga ctactccacc gcccgcgtgc
     4621 gcctggaggt catcggcggc gaggccgtcg ccatggtcca caccgccatg gcggaggtcg
     4681 gccagggcgg cgtcaccgtc cacgcccaga tcgcccgcac ggagctgggc gtcacccacg
     4741 tgacgatcca ccccgccgac acccaggtcg gctccgccgg ctccacctcc gcctcccggc
     4801 agacgtacat gaccggcggc gcggtgaaga acacctgcga ggccgtccgc gagaaggtcc
     4861 tggagatcgg ccgccggaag aacggctcct accaccccgc gtgggccacc gccgagctgc
     4921 tcctggaggg cggcaaggtc gtcaccgacg gcggcgaggt cctcgcggac atcgcggagc
     4981 tgctggaggg cgaggagccc atcgacctgg agctggagtt ccgccaccgt ccgacggccg
     5041 ccttcgacct ggtcaccggc cagggcgacg gccacgtcca gtacaccttc gccgcgcacc
     5101 gcgcggtggt cgaggtggac accgagctcg gcctcgtcaa ggtcgtcgag ctggcctgcg
     5161 cccaggacgt cggcaaggcc ctcaacccgc tctccgtcat cggccagatc cagggcggca
     5221 ccacccaggg cctcggcgtc gcggtgatgg aggagatcat cgtcgacccg aagaccgcga
     5281 aggtgcgcaa cccctccttc acggactacc tgatcccgac gatcctcgac accccgagca
     5341 tcccggtcga ctacctggag ctcgccgatc cgaacgcgcc gtacggcctg cgcgggctcg
     5401 gcgaggcccc gaccctgtcg tccaccccgg ccgtcctcgc ggcgatccgg gcggcgaccg
     5461 gcctggagct caccaagacg ccgatccgcc cggaggccct caccggcacc ctgtaggacg
     5521 gcgtcctccg ggggccgcga ggcccccgga ccgcgaactc tccgggcggc gcggcagcag
     5581 ggcccgcgcc ccgccgcacc gcccggagcc aaggaagtcc gggacgcccg ccgcaccgct
     5641 cgcggcacgt ccccggccgt acccccacgc aggaaccggc ggcaccggca ccccggcgcc
     5701 gccaccggaa ccaccagtac cgcagaaccc ccgcagtacc cgcagtacac gcagtgcaat
     5761 tcgcgtcgcc tcgggccgtc accccgggtc gtgcagccga acggcatttc ccaaatcccg
     5821 cagatcgcct ggcattccag gtgcgggtgc ccctttgaac cttgggagtt taggcaccat
     5881 gacccaatcg tctgtggagc ccaagaccac cgcggaagag gccggcgacg gctctcgcac
     5941 tcccgccggg cgttcttggc tcgaccggta cttccacatc acccatagag ggtccagcgt
     6001 cggcaacgag attcgtggcg gcgtcacgac gttcatggcg atggcgtaca tcctcctgct
     6061 caaccccctg atcctctccg gcaaggacgc cgccggggac accatgagcc agaaggccct
     6121 gatcacggcg accgcgttcg ccgcggccgt gaccaccctg ctcatgggct tcgtcggcaa
     6181 ggtgcccctc gcgctggccg ccggcctctc cgtgtccggc gtgctcgcct cgcaggtcgc
     6241 cccgcagatg acctggccgc aggccatggg catgtgcgtc atgtacggcg tcgtgatctg
     6301 tctcctggtc gtcaccggcc tccgcgagat gatcatgaat gcgatcccgc tggccctcaa
     6361 gcacgcgatc accatgggca tcggcctctt cgtcgcactc atcggcctgg tgaaggccgg
     6421 gttcgtgcac gagaaccccg cccccggcgg cggccccgtc accctcggcc cgacgggcga
     6481 gctggccggc tggccggtcc tgctcttctc cgtcaccctc ctgctcatct tcatgctgca
     6541 ggcccgcaag gtccccggcg cgatcctcat cggcatcggc gtcggcaccg tgctcgcggt
     6601 cgtcctgaac gcgatcgccg acgtcgaccc gaaggcctgg gccagcggcc cgccggagct
     6661 gaacggctcg gcggtctccc tgccggactt ctcgctcttc ggggaggtcg agttcggcgg
     6721 ctggggcgag gtcggcgcga tgaccgtcgg catgatcgtc ttcacgctgg tgctggccgg
     6781 cttcttcgac gcgatggcca ccatcatcgg cgtcggcacc gaggccaagc tggccgacga
     6841 caagggccgc atgccgggcc tgtccaaggc cctcttcatc gacggcgccg gcggcgccat
     6901 cggcggcgtc gcgggcggca gcggccagac cgtgttcgtc gagtccgcca ccggcgtcgg
     6961 cgagggcgcc cgcacgggcc tggcctcggt cgtcaccggc ctcttcttcg ccctgtgcat
     7021 cttcttcacc ccgatcacgc agatcgtccc cggcgaggtc gcctcggccg cgctcgtggt
     7081 gatcggcgcc atgatgatgc agaacgcccg ccacgtggac tgggcggacg ccgccaccgc
     7141 cgtgccggtc ttcctcaccg tcgtgatcat gccgttcacg tacacgatca cggccggtgt
     7201 cgccgccggt gtcatctcgc acgtcgccat caaggtcgcg cagggcaagg cccgcgagat
     7261 cggcgcgttc atgtgggcgc tcaccgcgat cttcgtggtg ttcttcgcgc tcgacccgat
     7321 cgagggctgg ctcggcgtcc actgacgcgg gccccgcccc cggtcctcca cgcatccgat
     7381 actggaaccg aaccccctcc aggaggcctc catgctggac atcgccgaag agctgaaccg
     7441 gtgggtcgag caagggcgcg acttcgccgt cgccaccgtc gtggcggtca ccggcagcgc
     7501 gccccggcag cccggcgcgg ccctcgccgt cgacgaggcg gggacggccg tcggctcggt
     7561 ctccggcggg tgcgtggagg gcgcggtgta cgacctgtgc gtgcaggcgc tccaggacgg
     7621 cgagaccgtc ctggagcgct tcggatacag cgacgacgac gcgttcgccg tgggcctgac
     7681 ctgcggcgga atcatcgaca tcctcgtgac cccggtccgc gccggcaccc ccgggcggca
     7741 ggtctacgag gccgcgctgg ccgccgccgc ccgcggcggg gcggccgccg tcgcccgcat
     7801 cgccgaaggg ccgcaggaac tgaagggcag cgccgtgctc gtcctcggtg aggacggcga
     7861 ggaccgcgag gaccgcgggg accgcttcct cggcggcttc ggcgggcacc ccgaactgga
     7921 ccgcatggtc gccgaggagg cccgcgccct gctcgacgcg gggaagaccg gcgtcctgga
     7981 ggtcggcgcc gacggccggc tgtgcggcga gccgctcaag gtgctcgtcg agtccagcgt
     8041 cccgcccccg cggatgatcg tcttcggggc catcgacttc gcgtccgccc tcgtgcggat
     8101 cggcaagttc ctcggctacc acgtgacgct gtgcgacgcg cggcccgtct tcgcgacgaa
     8161 gcagcgcttc cccgaggccg acgagatcgc cgtcgactgg ccccaccgct acctggagcg
     8221 cacggagacc gacggccgga ccgtgctgtg cgtcctcacc cacgacgcca agttcgacgt
     8281 gccgctgctg cgcctcgccc tgcgcctgcc cgtcgcctac gtcggcgcca tgggctcccg
     8341 caggacccac gaggaccgca accggcggct gcgcgacgtc ggcgtcaccg agctcgaact
     8401 ggcccgcctg cgctccccga tcggcctgga cctcggcgcc cgctccccgg aggagaccgc
     8461 cctgtccatc gccgccgaga tcgtcgccaa ccggcggggc ggctccgggg ccgcactgac
     8521 cggcgcccac atccccatcc accccgacgc cccggccacc gcggcccggc gcatcggctc
     8581 ggtggcctga cgggcgggcc gtacggaaaa agggcgtgcc gcgagggttg cgccctgctg
     8641 ggctcccccc tagttttacc ggccggtaac agcgcctttc cgcctgggag ttgagcgatg
     8701 ccccggaccg cccgcactgc ccgtacgccc gtccgcacgc tcctcgccgg cggcgtgctc
     8761 gccgccgcgg cgctcgcggc ggccgccgca cccgcgcccg ccgcaccccc cgcgcccgcc
     8821 tcggcccggc ctgccgcacc cgatgcggcc gggctgcgcg aggtgctctt cgtcggcaac
     8881 aactgggagg gcaccgccga cgtcctcgcc tccaccggcg gcatggagcg catcggccgc
     8941 atcaacgtcg tccccgacaa ggaggagcgc ctccgggaga tccacctcaa cccggtgaag
     9001 ctcgccttct tcctcgggat ccggcacagc gccggagagg gccacgacca gctcgtcgac
     9061 gacatgtaca ccacccccga cggctccgcc gtggtcgtct cccgcccgag cttcgccgac
     9121 gtcgtctccc tcgacctgcg caccggccgc atcaactggc gcttccccgt ctccggctac
     9181 cgctccgacc acatggccgt ctcgcccgac ggcacccggg tcgcggtgtc cgcgtccacc
     9241 tcgaacaccg tccacgtcct cgacatcgcg accggccgcc aggtcggctc gttcgccacc
     9301 ggcgacaagc cgcacgagaa caccttctcc cgcgacggcc ggctgatctg gaacgcctcc
     9361 atcggcgagg tcaacaccgc cctggacgcg ccctggctcg actggaccaa gggcgaccgg
     9421 aagttcaccg tcgtggacgc gcagaccttc cgcaccgtcc gcaccgtcga catgcgcgaa
     9481 cgcctcgacg ccgccggccg ctccgacctg tccgactcga tccggccgaa cgccttcacc
     9541 ccggacgagt cgatgctgta cttccaggtc tccttcttca acggcttcgc cgagtacgac
     9601 gtcgccgccg accgcatcac ccgcgtcaag accctcccga agaacccgaa gacccccgcc
     9661 gaccgcatgg cctgggtcaa cgactcccgc caccacggca tggccatgag cccggacggc
     9721 gcgaagctgt gcatcgccgg caccatggac gactacgcca ccgtcgtgga ccgggccacc
     9781 ctcgccgagg ggccgctcgt ccccgccgac aagccgtact gggcgaccgt cagcggcgac
     9841 ggcacggcct gcgtcatctc cgagagcggc tccgaccgcg tcaccgccat cgacttcgcc
     9901 accggcgaga agcgggtctc cgtccccgtc ggcgaccacc cgcagcgcgt ccgcctcggc
     9961 cgggtcccgg ccgactggac cgggacccgg tagccgcggc tcacgacggc agggagatcc
    10021 gcgccgccgc catcccgaac ccggggcccg ccaggagcgc ccgcagcccg gcgggcccag
    10081 gccgcagctc ctcgtcccgg taacggcgca cgctgcggtg ccagtggagg atcgccgcca
    10141 tccagtcctc cagctcccgc acgtacgagg cgagcgccgc ccgctccgcg gcccccagcc
    10201 cccggtcgtc gcacagcacc ggcagctggt ggtcgcggac gtgctcgaac tcccgggtgc
    10261 gctgcgccag caggtcggcg acgatcgcgg ccgcctgcgg gtagtcgatg ccgaagaagt
    10321 gctgcgcgac gagcacgtgg ttgtgcacct cgccctcgaa ctcgatctcc ttccggtacg
    10381 agaacaggtc gttgaccagg cagccgacgt cggcggcggc gctctccagc gagcggaccg
    10441 ccccctcgcg gcgcagctcc tccgggaagg cggtgccgtc cccgcggccg agccgggcca
    10501 ggaacatcgt caggtccgag ccgaaggtga agcggcgcat ctccgcgtag tccaccggat
    10561 ccggcacccg gttcacggcc gtgttcgcga tctcccagac ccaggagtcc agcatcgcga
    10621 cgacgtggcg gcggaacccc gcgcgcgcct gcccgtccag accggccgcg gtccgcgccc
    10681 acaggtccgc caggccgcgc tccagcgcgg tgagcggctc cgggccctgc cccggctccg
    10741 gcggcatcat cgcggcgagc cggtccgcag ccgcccgcgc gccgccgggg tcccgcgccg
    10801 cgccgaacac ccgcgggtag tagtcgtccc cgtacgtgcc ccaggccagc cactgcgcgc
    10861 ccagcgacag cgcctccggc gcggcgtccg ggtcgatgcc cgccgcgcac agcgccaggt
    10921 ccatgccggc cagcacgtcc tcggtccaga cgtccgagcc ggggtcgccg ggctgcggtt
    10981 cgagcatccc caccacccgg caccacgctg tgagttcgcg gcgggcccgg tccaggtgcg
    11041 ggttgaggga cagcgcgaac ggcaggtcga tgtccggcag gatccgccgc cccaccttcc
    11101 ggaacggcac gtgcgagaac cggcgccggc gcagctccag cgagcggggc gtgaggaccg
    11161 agcgccagtc cagggccgcc gtcccgaggc cgccgggcag gaacggcagg gtccgcgggg
    11221 cggagcgccg cgcctcctcg ttcatgtagc ggctggaggc catgtgccac tcgtggccgc
    11281 cggactgcca gtcctgcagg cccttcgcgt acgccaggac ggccgcggcc tcgtcggggc
    11341 cgagcccgtg gcgggcggcg agcgcgggca cctccgcgag ggccgtgtac tcgaactgct
    11401 ccagccggga cgtcagcagg tcgttggcca ggtcggcggc ctcctgcgtg gtgcagtcca
    11461 ggaaggtctc caacaccagg accgcgttgg agagttcgcc ctcctcctcg acctcgcgcc
    11521 ggtacgagaa gatgtcgttg cggatgtgca cggcatccga gaaggcgtcg cggagcacct
    11581 ggagcggccg cgcgtgggcc acccgggcgg ggacctccgc cgccacgtac tcgaccagcc
    11641 cggccgacca gggcgccccg ccgaccttgc ggcgcatctc gatgtactcc agcgggttcg
    11701 cgacccgccc catgccgatg ttgtgcagct cccacatcga ctcgttcagc aggttccgcg
    11761 tcgattcggc gaaccgttcc ctccacgccg cggacatcgc cgggaccgtg cgctgccaca
    11821 ggtccctcag gcccgcctcg acggggttgg ccggctcggg gaacccgtcc gcgaggtcca
    11881 tcggcatgaa cgcggccagt ccgtcgaggt acgcccgcgc gccctcgcgg tccccgctgc
    11941 gcttgtacac ctccaggaag tggtcgtcga agaagaacac ccacacgtac cagtcggtga
    12001 cgagctccag ggcgtcggcg ccgcagtcgg ggtgggtgta ggagcacagc agcgcgtagt
    12061 cgtgcgcgtc gaggtcctcc tgcgtccaga cgccggagcc ctccagcatc ccgaagcccc
    12121 gggcccaccg ccgggtgtgc tccctggcgg cctccaggtg cgggttgagt ctcgccgggt
    12181 acggcacgta gaagtccggc aggcggaacg gctgggtcac gtcggggcag gcctttcggt
    12241 ccggggctgc ggaaggccgg aaccgtcccc ggacgccgtc cccccgcacg ggatcggctg
    12301 tgccctaccc gcctcccggc cgccccaagt gccgcttcac cgcatcaggt gaagcggcgc
    12361 cgtccaccgc acgccgccgc gccgcggacg ctatgggcgg cggcgtgcgg ggcccgcgtc
    12421 agccgccgtc ggactccagg ttgccctcgg tgtccaggta cacctgccgc agcgcctcca
    12481 gcacctgcgg gtccggcttc tcccacatgc cgcgggactc cgcctccagc agccgttcgg
    12541 cgatgccgtg cagcgcccag gggttggcct cctccaggaa cgcgcggttc tccgggtcca
    12601 ggacgtacgt ctcggtcagc ttgtcgtaca tccagtccgc gaccacgccc gtcgtggcgt
    12661 cgtacccgaa caggtagtcc accgtcgccg ccagctcgaa ggcgcccttg tagccgtgcc
    12721 ggcgcatcgc ctcgatccac cgcggattga ccacgcgggc gcggaagacg cggctggtct
    12781 cctccaccag ggtgcgggtc ttgaccgtct ccgggcgggt ggagtcgccg atgtacgcct
    12841 ccggcgccgt gccgcgcagc gcgcggaccg tcgccaccat gccgccgtgg tactggaagt
    12901 agtcgtccga gtcggcgatg tcgtgctcgc gggtgtccgt gttcttcgcg gccaccgtga
    12961 tccgcttgta cgcggactcc atctcggcgc gcgccgggcg gccctccagg ccgcggccgt
    13021 acgcgtagcc gccccacacc gtgtagacct ccgccaggtc ggcgtcggtg cgccagtccc
    13081 gcgagtcgat cagctggagg atgccggcgc cgtaggtgcc cggccgggag ccgaagatgc
    13141 gggtggtggc gcgccgctcg tcgccgtgct cggccaggtc ggcctgcgcg tgggcccgta
    13201 cgaagttctg ctccgccggc tcgtcgagcg cggccacgag ccgtaccgcg tcgtcgagca
    13261 ggccgatgac gtgcgggaag gcgtcccgga agaagccgga gatgcgcagc gtgacgtcga
    13321 cgcggggccg gcccagctcg gcgggcggga tcgcctccag ggaggtcacc cggcgcgagg
    13381 cctcgtccca caccgggcgc acgccgagga gggccagcgc ctcggcgacg tcgtcgccgg
    13441 cggtgcgcat cgcgctcgtg ccccacaggg acaggcccac cgacgccggc cactcgccgt
    13501 tgtcggtgcg gtagcgctcc agcagcgact ccgccagtgc ctggccggtc tcccacgcga
    13561 ggcgggaggg cacggccttc gggtcgacgg agtagaagtt gcggccggtc ggcagcacgt
    13621 tgaccaggcc gcgcagcggc gagccggacg ggccggccgg gacgaaccgg ccgtcgagcg
    13681 cggccaccac gtgcgcgatc tcgtcggtgg tgccggccag gcgggggacg acctcgcggg
    13741 ccgcgaagtc cagcaccgcc gcgacctgct ccgggtgccc ggcggctacc cgggacacgg
    13801 cggccgggtc ccagccggcg tcctccatcg cctgcaccag cccgcgcgcc gcctcctccg
    13861 cctcgtcggc ggaggtgcgg gtcgccttgg actcgtccag gccgagggcc tcgcgcaggc
    13921 cgggcagggc cgtggtgccg ccccagatct ggcgggcgcg caggatggcc aggaccaggt
    13981 tgacgcgggc ctcaccggcc ggggcgccgc ccaggacgtg caggccgtcg cggatctgcg
    14041 cgtccttcac ctcgcacagc cagccgtcga cgtgcagcag gaagtcgtcg aagccgtcgt
    14101 cgtccgggcg ctcctccagg cccaggtcgt ggtcgagctt cgcggcctgg atcagggtcc
    14161 agatctgcgc gcggatcgcc ggcagcttcg ccgggtccat ggcggagatc tgcgcgtact
    14221 cgtcgaggtg ctgctccagg cgcgcgatgt cgccgtacga ctcggcgcgc gccatcggcg
    14281 gcaccaggtg gtcgacgagg gtggcgtgca cgcgccgctt ggcctgggtg ccctcgcccg
    14341 ggtcgttgac gaggaacggg tagacgagcg gcaggtcgcc gagcgccgcg tcgggggcgc
    14401 aggccgcgga caggcccgcg ttcttgcccg gcagccactc caggttgccg tgcttgccga
    14461 ggtggatcat cgcgtcggcg ccgaagccgc cgtcctcggc ggcggcctgg atccaccggt
    14521 aggcggccag gtagtggtgc gacggaggca ggtccgggtc gtggtagatc gcgatcgggt
    14581 tctcgccgaa gccgcgcggc ggctggatca ggatcagcag gttcccgcgg cgcagcgccg
    14641 cgaggacgat gtcgccctcg gggttggccg agcggtcgac gaacatgctg ccgggggcct
    14701 caccccagtg ctcctcgacc tgctcgcgca gctccgccgg cagttcggcg taccagcgcc
    14761 tgtagtcggc cgcggggatg cggaccgggt tgcgggcgag ctgctcctcc gtcagccagt
    14821 cctggtcgtg gccgccggcc tcgatcaggg cgcggatcag ctcgtcgccg tcgccggaga
    14881 ccaggcccgg gatgtcctcg gccggcccga agtcgtagcc gccgtcgatg agggcgcgca
    14941 gcagccggac cgcgctcgcc ggggtgtcga ggcccacggc gttgccgatc cgggagtgct
    15001 tcgtcgggta cgccgacagc accagtgcga tcttcttgtc ggcgcgggcg atgtgccgca
    15061 gccgggcgtg ccgcacggcg atcccggcga cgcgcgcggc gcgctcgggg tcggcgacgt
    15121 aggcgggcag cccgtccgcg tcgaactcct tgaaggagaa cggcacggtg atcaggcggc
    15181 cgtcgaactc ggggacggcg acctgcgtcg cggcgtccag cggggacagg ccctcgtcgt
    15241 tctcctccca ggcgctgcgc gacccggtca ggcacagcgc ctgcaggacg ggcacgccga
    15301 ggcgggccag cgcgccggcg tcccaggact cgtcgtcccc gccggcggag gcggtcgccg
    15361 ggcgggtgcc gccggccgcg aggacggtcg tgacgacggc gtcggcgccc tccagcgcgg
    15421 cgagcaactc cggctcgggc gtgcgcaggg aggacacgta cagcggcacg ggcgacccgc
    15481 ccgccgcggt gatcgcgtcg cacagcgcgt gcacgaaggc ggtgttgccg ctcatctggt
    15541 gggcgcggta gtacagcacg gcgatccgcg ggccgtcggc cgcggcggac ggggcgtcgg
    15601 ggcgctccag cgggccccac gtcggcgcgg cggcgggcgg ctcgaagccg tggccggtca
    15661 gcagcaccgt gtcggacagg aagcgggcca gctgctccag gttgtccggc ccgccgtgcg
    15721 cgaggtaggc gtgcgcctcg gccgcgatgc cgatcgggac ggtcgaggcc tccatcagct
    15781 gcgcgtccgg ggcctgttcg ccggtcagca cgacgaccgg gcgggtctgc tcgcggtcca
    15841 ggagcgcctc caggccgtcc tcccaggcgc gcaggccgcc gaggaggcgt acgacgacca
    15901 ggtcggcgcc gtcgaggagg ccgggcaggt cgtccagggg aaggcgggag gggttcgcga
    15961 accggtaggg gacggggccc ccggcggcgc gggcgctgag cagatcggtg tcggacgtcg
    16021 acagcagcag gatcatgcgg cggcaggcct tcctcggggt ttccgcgccc cgggcagtgg
    16081 ggacggcggg agttcctggc tcacccggcg ccgagcggct gctctgccgg gctcacagtg
    16141 gcgggaccgc gccggaatcg caccgggctt cctcccatgt cgccgtcctc ggcgatgagc
    16201 gggccgtgtg gcacgccgaa ggtcatctta ggtgccgccg cccccggccg ggagtcgggg
    16261 agggtggcgt cggccacagc tcacgggagc atggggggag cgcatcggtg ggtatgctcg
    16321 ccgccatgcc ccagccccct tccgccgtat cgcgggacga accggtcata cgtgaccgcg
    16381 gtgacgcctg cccgggcgca ctgcggctcc acgccgccga cgacgggttc ctggcccgga
    16441 tccggatccc cggcggcatc ctcggcgcgg acgcggcccg gctgctcgcc gacgcagcgg
    16501 accggctcgg cgacgggcac atcgacctca cctcgcgcgg caacgcccaa ctccgcggcc
    16561 tcggcgcgtc ctgcggcggc gaactggccg ccgtcctgga gcgggccggg ctgctgccgg
    16621 cgcccggaca cgagcgggtc cgcaacgtcg tcgcctcacc gctgaccggc ctggacgggc
    16681 gggggcgggc ggacgtcgca ccctgggtcg cccgcctgga ccgggagctg tgcgcagagc
    16741 cggccgcggc cgcactgtcg gggcggttcc tgttcgccgt cgacgacggg cgcggcgacg
    16801 tgctgtccct gtccgccgac gccaacgtcc tggcatgcgg gggcgggcag gcgctgctgt
    16861 ggctcgggcc gggcggcccg gactcccggg ccgcccgcgt cgccgcggac gacgcgccgc
    16921 gcgccgccgt ggcagccgcc ctgtgcttcc tcgacgcggc ccgcgccgcc ggcacccgcg
    16981 cctggcgggt cgccgagctg ccgcccgaac accgcccgga cgccgccggg ttggcggcgc
    17041 gcctcgccgc cgccgggatc ccggccgagg tggttccgct cgacgccccg cagggcccag
    17101 gcgggcccga gcccctgccc ggcgtcgtgc gcggcacctc cggcggaccg gccgcgctgt
    17161 ccgtcctcgc cccgctcggc cgcctcgaca ccgcccagtg gcggctgctg gccgggctgt
    17221 cgggccgcat gcggctcacg ccctggcggg gcgtcgtcgt ccccgggctc gccgccggcg
    17281 ccgcggactc cgccctcgcc gccctcgccc gcgccggcct cgccaccgcc cccgacagcc
    17341 cctggcggtc cgtcaccgcc tgtacggggc gccccggttg cgccaaggcg ctcgccgacg
    17401 tacgggccga cgcgcgcgcc gtcgcggccc gggcgaccgg accgctgccc gtgcactggt
    17461 ccggctgcga gcgccgctgc ggccaccccc gcggcaccgc gtgggtcgac ctggtcgcca
    17521 ccggcgacgg gtacgccgtc acgctcgccg cagccggaac cgccggtccg gcgcaccgga
    17581 ccgtgaagac ttccgaactg gccgcggtcc tcgcggacgc acgccgcact gacgcatgcc
    17641 gcaccccctc ccacgacgca gcgaagaaat gagcgagtac acagtgttcg agtacgagaa
    17701 ggacggggcg gagatctacc gccagtcctt tgccacgatc cgcgccgagg cggacctctc
    17761 cggactgccc gcctccgtgg cgcaggtcgc ggtgcgcatg atccacgcct gcggaatgac
    17821 cgacctgccc caggacctcg gctacacccc ggacgtcgtg ctccgtgccc gggccgccct
    17881 gcacgcgggc gcccccatcc tctgcgacgt gcagatggtc gccagcggcg tcacccgcaa
    17941 gcggctcccc gccgacaacc aggtcgtctg caccctctcc gacccggccg tccccgcgct
    18001 cgccgcccgc atgggcacca ctcgcagcgc cgccgccctg gaggtgtggc gcgaccgcgg
    18061 cctgctggag ggctccgtcg tcgccgtcgg caacgccccg accgccctgt tccgcctgct
    18121 ggagatgatc gaggagggcg ccccgcgccc ggccgccgtc atcggcgtgc ccgtcggctt
    18181 catcggcgcc gccgagtcca aggacgccct cgccgcgcac ccctcgaacc tcgaccacct
    18241 ggtcgtccgc ggccggcgcg gcggcagcgc cctcgcggcc gccgccctca acgcgatcgc
    18301 gagcgaggaa gaatgagcac caccgcagca acccccgcag cgacccccgc agccgccggg
    18361 agcgcggccg ccccggccaa gggccgcctc tacggcgtcg gcctcggccc cggcgacccg
    18421 tccctgatga cgctgcgcgc cgtcgaggcc atcgccgagg ccgacgtcgt cgcctaccac
    18481 agcgcccgcc acggccgctc catcgcccgc tcgatcgcgg cccgccacct gcgcgccgac
    18541 catatcgagg agccgctggt ctacccggtc accaccgaga ccaccgacca cccgggcggc
    18601 taccagggcg cgatggagga gttctacgag gcctccgccg cccgcctggc cgcccacctg
    18661 gacgccggcc gcaccgtcgc cgtcctcgcc gagggcgacc cgctcttcta cggctcctac
    18721 atgcacatgc acaagcggct cgccgaccgg tacgaggccg aggtgatccc cggcgtgacc
    18781 tcggtcagcg ccgccgccgc ccgcctcggc accccgctcg tcgagggcga ggaggtcctg
    18841 acggtcctcc ccggcaccct ccccgaggag gagctcgccg cgcggctcgc cgcgaccgac
    18901 tccgcggtcg tcatgaagct gggccgcacc ttccccgccg tccgccgcgc cctggagacg
    18961 agcggccgcc tcgccgaggc gcgctacgtg gagcgggcca ccatggacgg cgagcggacc
    19021 gggctgctcg ccgacaccga cccggacacc gtcccctact tctccgtcgc ggtcgtcccc
    19081 agccgtgtcg gcaaccccgg cagcgtcccg tccggccccg gcgaggtcgc cgtcgtcggc
    19141 accggccccg ccggaccgct gtggctgacc cccgagacgc ggcgggcgct gtccgacgcc
    19201 gaggtcctcg tcggctacac cacctacctc gaccgggtcc ccgccaggcc gggccagatc
    19261 cggcacggct ccgacaacaa ggtcgaggcg gagcgcgccg agttcgccct cgacctcgcc
    19321 cgccgcggca agcgcgtcgc cgtcgtgtcc ggcggcgacc cgggcgtctt cgccatggcc
    19381 accgccgtcc tggaggccgc cgcgcaggac gcctacaagg acgtgcccgt acgggtcctg
    19441 cccggcgtca ccgccgccaa cgcggccgcc gccgcggccg gcgccccgct cggccacgac
    19501 tacgccaccg tctccctgtc cgaccggctc aagccctggg aggtgatcgc ggaacggctg
    19561 cgcgcggccg ccgccgcgga cctcgtcctc gccctgtaca acccgggctc gcgcagccgg
    19621 acctggcagg tcgccaaggc ccgcgacctg ctgctggagc tgcgctcccc gcacaccccg
    19681 gtggtcgtcg cccgcgacgt gggcggcccg gagcagtccg tccgcgtcgt gacgctggag
    19741 acgctggagc cgtccgaggt cgacatgcgg accatcctgc tgatcggctc ctcgcagaca
    19801 caggtcacgg agcggcccga cgggacctcc gtcgcctgga cgccccgccg ctacccctga
    19861 cgggcggcgg cagccgcagc agggcccggg gcacgacggc gccgggcgct gccgcggcgg
    19921 ctcaggaccg gcctgccggg ccgtgcagcc accgcgcggc ggcagccgcc gtacccgcct
    19981 ccggcacccc ggccggcacc ggcgggcggc gcaccaccag caccgggaca cccgcctcgc
    20041 gggcggcggc cagcttcggg gcggtcgcct ggccgccgct gtccttggtg acgaggacgt
    20101 cgatgcggtg ccgggcgagc agcgcgcgct cgtcgtccag gctgaacggc ccgcgcgcca
    20161 ggaggacttc caggcgcggc ggcgcgggcg ccgccggcgg gtccaccgag cgcaccagga
    20221 accacgggtc cgcgaggtgc gcgaaggcgt gcagaccggt ccggccggtg gtcaggaaca
    20281 cccggctgcc gagcccgggc aggagggacg cggcctccgc gaggtcggcg gcgaacgtcc
    20341 agtcgtcccc cggcccgggc gaccatccgg ggcggcgcag cgccagcagc ggcacgcccg
    20401 ccagccgggc cgcggccgcc gcgttgaagc tcatccgctc cgcgaacggg tgggtggcgt
    20461 cgacgagatg cgtgaccgcg tgcgcggcga tccaggcggc gagcccctcc ggcccgccga
    20521 acccgccgat ccgcaccccg cccggcggca gcaccggcgc ggccacgcgg cccgccaggg
    20581 acgtcgtcac ccgccacggg cggcccgcgg cgtccgccgc cccctccgcg aggagctccg
    20641 cgaggcgccg ggcctcggtg gtgccgccca gcaccaggac gtgcggcccg gatcccgcct
    20701 cagcagacat gccggtcgcg ctcgggcgag tacaggtggc tgtcgcggaa ctgctccgcg
    20761 cccagcgtcc ggcccacgat gatgacggac gtgcggacca ggcccgcctc cttcacctgc
    20821 ccggcgatgt cggccagcgt gccgcgcagg accagctcgt cggggcggct cgccatcgcc
    20881 accaccgcgg ccgggcactc ggccccgtag tgcggcagca gctcctccac gacccggtcg
    20941 acgtagcggg tcgccaggtg cagcaccagc agcgccccgc tgcggcccag cgtggcaagg
    21001 tcctcgcccg gcggcatcgg cgtggcctgc tgcgcgatcc gggtcaggat caccgtctgg
    21061 ccgaccgtgg gaaccgtcag ctcccgcttc agcgcggccg ccgccgccgc gaacgccggc
    21121 acgccgggca cgacctcgta cgggatcccc gccgcgtcga gccggcgcat ctgctcggcg
    21181 accgcgctga agaccgacgg gtcgccggag tggagccgcg ccacgtccag gcccgcctcg
    21241 tgcgcccgta cgcactcggc gatgatctcg tccaggttca ggcgggaggt gtccaccagg
    21301 cgggcgccgt ccgggcactc ggcgagcagc tcgcgcggga cgaggctgcc ggcgtagagg
    21361 cagaccgggg cggcggccag cgtccgggcc ccgcgcaccg tgatcaggtc ggcggcaccg
    21421 gggcccgccc cgatgaagta cacggtcatg actgctggtc cttgtcgtcg tcggaggatg
    21481 aggaggaggg aggggcgggg gagccgcaag aggccggggg agcggccggc ttgacgacgg
    21541 accactgggt caccggcatc gcctgccgcc agcccgtgaa cccgccgacg ggcacggcgt
    21601 gcgcgacgga cagcttgacc aggtcgccgc cgtggcggcg gtgccgctcg ccgaggacgg
    21661 cctcggactc cagggtgacc gtgttcacga cgagccggcc gccgggcggc agcgcctccc
    21721 agaccgcgtc cagcagaccg ggcgcggtca gcccgccgcc gacgaacacc gcatccgggg
    21781 cgggcagtcc ggccagcgcc gcgggagccg agccggtcac cacgcgcagc ccgggcacgc
    21841 cgagcgcggc cgcgttgcgg ccgatccggc cggcccgctc cgggacgcgc tccaccgcga
    21901 ccgcccggca ggacgggtgc gtccgcatcc actcgatgcc gatcgagccg gagccgcccc
    21961 cgatgtccca cagcagctcc ccgggcgccg gggccagcgc gcacagcgtc gccgcccgca
    22021 catggcgctt ggtgagctgg ccgtcgtgct cgtacgccgc atccggcagg cccggcgtcg
    22081 cgccgagccg cgggaccgcg gaggccgggt cccggcggca gtccaccgcc accacgttca
    22141 gcgggtcgcc cggcggacgg tcccagccgt cggcggtgcc ctcgtacgcg tcctcgcgct
    22201 ccgagccgag ctgctccagc
//
