LOCUS       NZ_CP030862            11308 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces globosus strain LZH-48 chromosome, complete genome.
ACCESSION   NZ_CP030862
VERSION     NZ_CP030862.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globosus
  ORGANISM  Streptomyces globosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Draft genome Sequence of streptomyces globosus LZH-48
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Institute of Biophysics, Dezhou University,
            566 DaXuexi RD, Dezhou, Shandong 253023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Portal v. version 2.2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003325375.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:22:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,671
            CDSs (total)                      :: 6,576
            Genes (coding)                    :: 6,458
            CDSs (with protein)               :: 6,458
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 41 of 118
            Pseudo Genes (incomplete)         :: 101 of 118
            Pseudo Genes (internal stop)      :: 11 of 118
            Pseudo Genes (multiple problems)  :: 32 of 118
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:39:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1943520
            Orig. end                         :: 1954828
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030862.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11308
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11308
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11308
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6308](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6308)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(342..1433)
                     /locus_tag="C0216_RS08980"
                     /old_locus_tag="C0216_08975"
     CDS             complement(342..1433)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025616.4"
                     /locus_tag="C0216_RS08980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_08975"
                     /product="DUF4349 domain-containing protein"
                     /protein_id="WP_162793147.1"
                     /transl_table=11
                     /translation="MRARSSWTTTTTRTTRTGRRGAAALAGLALAGSLALAGCGADGGS
                     AGSAAADKAAVAPAAPQGEARTGAGAAGPAAEGAAKAPGAPAPGGQAPAAVRPHVVRTA
                     SLAIEADDAGKVLASARTAAEGAGGFVGNESTRRGKDGRMASAMTLRVPSERFDAVLGA
                     LEGSGKLLSRKVEAQDVTEKVADVDSRVRSQQASVARVREMMERATALGDVVMLEGELS
                     RRQSDLESLLAQQTALKDRTSLGTVTVEVSEPEAAAGPSEDDGRPSVGGALRTGWEAFT
                     DVVAYAVVAVALVLPFAAAAAVGVLGFRFLRRRRRGGGAAAAAAPAGVEAPAGVEAPAA
                     SAAPAVPPARDGGDPAETPRVSD"
     gene            1584..3065
                     /gene="hemG"
                     /locus_tag="C0216_RS08985"
                     /old_locus_tag="C0216_08980"
     CDS             1584..3065
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267196.1"
                     /locus_tag="C0216_RS08985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_08980"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_114058540.1"
                     /sec_met_domain="DAO (E-value: 1.7e-07, bitscore: 29.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHEADTRTHDGTHGDGAPGAPGTDPRRRVLVIGGGIAGLAAAHRL
                     LAAGLRVTLLEAGQRLGGKLHAGELAGLPVDLGAESVLARRPEALDLARAVGLGPALQP
                     PATTTAHLWTRGALRPMPTGHVMGVPGDTAPLAASGVLSAEGLARIAAEADLPPADIGE
                     DAAVGEYVAARLGREVVDRLVEPLLGGVYAGDAYRISLRAAVPQLYEAARRHGSLGDAV
                     RDLQRRAAAQPAQGPVFSGIEGGIGRLPAAVADACRAAGAEISTGAEVRELRRTAAGWR
                     AVTAAGAVDADAVVLAVPAGPAARLLQDAAPAAAAELRAVEYASMALVTMAFRRSELPA
                     AITAGTASGFLVPPVDGKTVKASTFSSSKWAWAGTDPDLFLLRTSVGRHGDEADLARED
                     SELVGVSLRDLGEAVGLTARPVASTVTRWGGGLPQYPVGHLDRVARIRAAVGALPGLAV
                     CGALYDGVGIPACIASAGKAADAVAAALATPGSEH"
     gene            3089..3802
                     /gene="hemQ"
                     /locus_tag="C0216_RS08990"
                     /old_locus_tag="C0216_08985"
     CDS             3089..3802
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888541.1"
                     /locus_tag="C0216_RS08990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_08985"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_114054760.1"
                     /transl_table=11
                     /translation="MTAPEKIPNAGKKAKDLNEVIRYTLWSVFKLKDVLPEDRTGYADE
                     VQELFDQLAAKDITVRGTYDLSGLRADADIMIWWHAETADELQTAYNLFRRTRLGRALE
                     PVWSNMALHRPAEFNKSHIPAFLADEVARDYVSVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGYPDVRANTVASFSLGDYEWLLAFEADELHRIVDLMRHLRASEARMHVREEVPFF
                     TGRRKSVADLVAGLA"
     gene            complement(4003..5004)
                     /locus_tag="C0216_RS34945"
                     /old_locus_tag="C0216_08990"
     CDS             complement(4003..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554827.1"
                     /locus_tag="C0216_RS34945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_08990"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_281277910.1"
                     /transl_table=11
                     /translation="MTGFAVVWLPVAVSSVLLVWALRRTRPRTGGEPPRLLDLSEAAFL
                     TGGPGGVVDTALVVLLGDGRLTAGGPGIVQARPGAPAADTAERAVLRACGQAPSGRLYQ
                     VRYAAMRDPAVQEVGDGLAARGLLTAPGRGRGVRVWGVVQAAVCGVLFLLSLPLVLFTL
                     AVSGGGGVPAGVSLLFALPAGAVVGAVCARRAARRVTPRGRRALRAMRAVYVGDGSPQA
                     QTALFGLRTLRDPYLGPLLVPAARQARLAAAEHRAQGGRSGRSGGGGGGSDGCGSSGAE
                     AVPVVWCAGSGGGSGCGSSGDGGWGGSGCGSSGGSSCSSSSSSSSCSSSSSS"
     gene            complement(5001..6308)
                     /locus_tag="C0216_RS09000"
                     /old_locus_tag="C0216_08995"
     CDS             complement(5001..6308)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238120.1"
                     /locus_tag="C0216_RS09000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_08995"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_114054762.1"
                     /sec_met_domain="DUF692 (E-value: 7.2e-88, bitscore: 292.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLGVGIGWRPEIADAVERLPGLDWVEVVAENICPGHLPEPLQR
                     LLDRGVRVVPHGVSLGLGGAEPPDAGRLAALAERAVALGAPLVTEHIAFVRTASPALEA
                     GHLLPVQRTRDALDVLCENVRIAQEALPVPLALENIAALVRWPGEELTEAQFLTELVER
                     TGVRLLIDVANLHTNRVNRGEDPAAVLAAVPPEALAYVHVAGGVERDGVWHDTHAHPVP
                     PAVLDILADLAGRMRPAGVLLERDDAFPPEKELAAEFAAIRSTLEAAAAAPVLGGGGAP
                     AGAVPGGVRGARAAAGGLSAARTRVGLEQAALLSSLVAGTPVPEGFDRQRVRVQARALA
                     AKRADIVAKVAPELPELLGGRKAFREAFLGYARHRPLPGGYRRDALDFAEHLLVRDLPA
                     DPAARRRLTVWWRDRAGPKPPGRIVRWARALTGRAA"
     misc_feature    complement(6622..6635)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.53"
                     /tool="antismash"
     gene            complement(6839..7042)
                     /locus_tag="C0216_RS09005"
                     /old_locus_tag="C0216_09000"
     CDS             complement(6839..7042)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035291.1"
                     /locus_tag="C0216_RS09005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09000"
                     /product="hypothetical protein"
                     /protein_id="WP_114054763.1"
                     /transl_table=11
                     /translation="MNAEDVAELHAAMRAYGIPGTLAPVDAGDPAGEWRVLDSAGRDVT
                     AGTLAAAATARARRPARGFVVG"
     gene            complement(7073..7621)
                     /locus_tag="C0216_RS09010"
                     /old_locus_tag="C0216_09005"
     CDS             complement(7073..7621)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015034217.1"
                     /locus_tag="C0216_RS09010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09005"
                     /product="hypothetical protein"
                     /protein_id="WP_246042413.1"
                     /transl_table=11
                     /translation="MTCNNTPPGAPPPPCTVKPAGGAAPSPRRLLTDAQFNDVRATVLD
                     NNPGMAPDMATRIVVEVLKFVVAASLFPTVRIAPTREVDEGWHALILHTHLYATLCSRL
                     GRTVHHYPERPDESRHDPDVLTRTVALIEQAGYSPDAELGPGPERSLVSVAASCSHTPV
                     PGGCGPIRPGQCATHGGDE"
     gene            complement(7697..7834)
                     /locus_tag="C0216_RS33380"
     CDS             complement(7697..7834)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS33380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162793148.1"
                     /transl_table=11
                     /translation="MRPRPAPPAETPASAGAVTERARQALYVLIVLSTLGTLAVGIARP
                     "
     gene            complement(7947..8126)
                     /locus_tag="C0216_RS09015"
                     /old_locus_tag="C0216_09010"
     CDS             complement(7947..8126)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS09015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_09010"
                     /product="hypothetical protein"
                     /protein_id="WP_162793149.1"
                     /transl_table=11
                     /translation="MPLPAFSDLTIEQARGKACVACGKLLGLGRIYRGPILGYDGPMLL
                     DVDVWSCPPPAAGR"
     gene            complement(8150..8383)
                     /locus_tag="C0216_RS09020"
                     /old_locus_tag="C0216_09015"
     CDS             complement(8150..8383)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS09020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_09015"
                     /product="hypothetical protein"
                     /protein_id="WP_114054765.1"
                     /transl_table=11
                     /translation="MAARYTLTPSPERVGTSVPHAWLGRDVQDLLDGRCGTLMDVCVEE
                     NQYGLRYDAAYIRGADAREFVIPVTQMRLVSC"
     gene            8503..9612
                     /locus_tag="C0216_RS09025"
                     /old_locus_tag="C0216_09020"
     CDS             8503..9612
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007492231.1"
                     /locus_tag="C0216_RS09025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09020"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_114054766.1"
                     /transl_table=11
                     /translation="MDSNATGTLTRGQGSQHRPRGGIVSGYVFRVIREQLDHTQESLAE
                     VFHVSPDTVAGWESGRRPLTSLAVGQMLVHRHRLMRMGVSPGLLLALEKALEADVLLAS
                     ALTDDGPTGDSPLGAWVMQRDLVEVLAWPLTGVTPEPMRALQAPSKPRRGPAPRGPELS
                     VGDRRRFFRCMRRTAEEAGPGQFLRRRQALYLAGYDDAPDTSEWLAQQQRAERPGDWLT
                     QWLAARSVAAVAARQGDRDRMQHFISTTLDDDAGEAANLNYWAYWIGESTHIQISDDFI
                     ATHSAPWHGHKLLQHLVNGLVPHQGFFDLNLHTLWALLAARPTLLRATSATGRALRDRL
                     PVLLDGTEPWTRARRELEGIRYAIRLAEA"
     gene            9625..10203
                     /locus_tag="C0216_RS09030"
                     /old_locus_tag="C0216_09025"
     CDS             9625..10203
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006348500.1"
                     /locus_tag="C0216_RS09030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_09025"
                     /product="HD domain-containing protein"
                     /protein_id="WP_114054767.1"
                     /transl_table=11
                     /translation="MADDLSAVARFLYEAGTLKHTRRTGWWMAGINDPESVAEHSWRTS
                     LIASIIAKLEGADPARAAFLAVWHDTQETRTGDVNHLGKKYASSADPEAVTADQTAGMP
                     EVLASTIQDLVAEYEAKGSPEAICARDADKLECMLQGIEYKAQGYQAAQRWIDNSRARL
                     TTETGQRLADELLGQGTLDWLRAAIGETN"
     gene            10563..10781
                     /locus_tag="C0216_RS09035"
                     /old_locus_tag="C0216_09030"
     CDS             10563..10781
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS09035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_09030"
                     /product="hypothetical protein"
                     /protein_id="WP_114054768.1"
                     /transl_table=11
                     /translation="MDPSRGILAAGVFSAALAIPAFPDLAGADTPDPVRPGKGTVRIGR
                     AQAASVRAMTDRIADFLAARSVGARKA"
ORIGIN
        1 ggacgcggtt cccggccagg tccagctcca gcacctccgt acgggtgcgc aggtcgatgc
       61 cgcgggcgcg gtgctcctcg ggggtgcggg cgatcaggtc gtcccggtcg gtgacgccgc
      121 cgccgatcca gtacgggatc ccgcacgccg agtacgaggt gaagcggccc cgctcgaagg
      181 ccgtgatctc cagctccgca gggcccttca gccgccgggc ctgcgacgcg gcggacatcc
      241 ccgccgcgtc gccgccgacc accaccagcc gttccactgc catcgtccgc accgtcctcc
      301 actgtggcca cgtggagaac acgctacggg ggagcggttg ttcagtccga gacccggggc
      361 gtctccgccg ggtcgccccc gtcccgcgcc ggcggaacgg ccggggcggc ggaggccgcg
      421 ggagcctcca cgcccgccgg ggcctccacg cccgccgggg ccgccgcggc ggccgcgccg
      481 ccgccccgcc gtcggcggcg caggaaccgg aagccgagca cgccgaccgc ggcggccgcc
      541 gcgaacggca gcaccagcgc caccgcgacg acggcatacg ccacgacgtc cgtgaacgcc
      601 tcccagccgg tccgcagcgc acccccgacc gacggccggc cgtcgtcctc cgacggcccg
      661 gccgcggcct ccggctccga gacctccacg gtgaccgtgc cgagcgaggt ccggtccttc
      721 agcgcggtct gctgcgccag cagcgactcc aggtccgact ggcgcctgct cagctcgcct
      781 tccagcatca ccacgtcgcc gagggccgtg gcccgctcca tcatctcccg cacccgggcg
      841 acgctcgcct gctgcgagcg gacccggctg tcgacgtccg cgaccttctc cgtcacgtcc
      901 tgcgcctcca ccttccggct gaggagcttc ccgctgccct ccagggcgcc gagcacggcg
      961 tcgaaccgct cggagggcac ccgcagggtc atcgccgacg ccatccgccc gtccttgccg
     1021 cgccgcgtcg actcgttgcc gacgaacccg ccggcgccct ccgcggccgt ccgggccgac
     1081 gccagcacct tccccgcgtc gtccgcctcg atcgccagcg aggccgtcct gaccacgtgc
     1141 ggccggaccg cggccggggc ctgcccgccc ggcgccggcg cgcccggcgc cttcgccgcg
     1201 ccctccgccg ccgggccggc cgccccggcg cccgtacggg cttccccctg gggggcggcc
     1261 ggcgccaccg cggccttgtc ggcggccgcg gagccggccg acccgccgtc ggcgccgcag
     1321 ccggcgagcg ccagcgagcc cgccagggcc agcccggcca gcgcggccgc accgcgccgc
     1381 cccgtccgtg tcgtgcgcgt ggtcgtggtg gtccaactgg agcgtgctcg cactgcggtc
     1441 cccccggggg tcggatgccg tcgtgccgtt tcgacgcgca cgcccgcccc gcgggtttcg
     1501 ccccgccggt cccgggacgg tcccgatgcg gtcacggtcc ggcctcggca cagccccgga
     1561 acccggtctg agagcatgtg tccatgcacg aagcggacac gcgtacgcac gacggcaccc
     1621 acggcgacgg cgcgcccggc gcccccggca cggacccccg ccgccgggtc ctcgtcatcg
     1681 gcggcggcat cgccggcctc gccgcggccc accggctcct cgccgcagga ctccgcgtca
     1741 ccctgctgga ggccgggcag cgcctcggcg gcaagctgca cgccggcgaa ctcgccggcc
     1801 tccccgtcga cctcggcgcc gagtccgtgc tggcccgccg cccggaagcc ctcgacctcg
     1861 cccgcgccgt cggcctcggc ccggcgctcc agccgcccgc caccaccacc gcccacctgt
     1921 ggacccgcgg cgcgctccgc ccgatgccga cagggcacgt catgggcgtc cccggcgaca
     1981 cggcaccgct ggccgcctcc ggcgtcctct ccgccgaggg cctcgcccgg atcgccgccg
     2041 aagccgacct gccgcccgcc gacatcggcg aggacgccgc cgtcggcgag tacgtcgccg
     2101 cccgcctcgg ccgcgaggtc gtcgaccggc tcgtcgaacc cctcctcggc ggcgtctacg
     2161 ccggcgacgc ctaccgcatc tccctgcgcg ccgccgtccc gcagctgtac gaggccgccc
     2221 gcaggcacgg ctcgctcggc gacgccgtac gcgacctcca gcgccgggcc gcggcccagc
     2281 cggcgcaggg ccccgtcttc tccggcatcg agggcggcat cggccgcctc cccgccgccg
     2341 tcgccgacgc ctgccgggcc gccggcgccg agatcagcac cggcgccgag gtccgcgaac
     2401 tccggcgcac cgcagccggc tggcgggccg tcaccgccgc cggcgccgtc gacgccgacg
     2461 ccgtcgtcct cgccgtgccg gccggccccg ccgcccggct gctccaggac gccgccccgg
     2521 ccgccgcggc cgagctgcgc gcggtggagt acgcctcgat ggccctcgtc acgatggcgt
     2581 tccggcgctc ggagctgccc gccgcgatca ccgccggaac ggccagcggg ttcctcgtac
     2641 cgcccgtcga cggaaagacg gtcaaggcgt ccaccttctc cagcagcaag tgggcctggg
     2701 ccggcaccga ccccgacctc ttcctgctgc gcacctccgt cggccgccac ggcgacgagg
     2761 ccgacctggc ccgcgaggac tccgaactcg tcggcgtctc gctgcgcgac ctcggcgagg
     2821 ccgtcggcct caccgccagg cccgtcgcct ccaccgtcac ccgctggggc ggcggactgc
     2881 cgcagtaccc ggtcggccac ctcgaccggg tcgcccggat ccgggccgcg gtcggcgcac
     2941 tgcccggcct cgccgtgtgc ggcgccctct acgacggcgt cggcatcccc gcctgcatcg
     3001 ccagtgccgg gaaggccgcc gacgcggtcg ccgccgcatt ggccacccct ggctccgagc
     3061 actgatcggc acacgggaca atggacgcat gactgcacca gagaagatcc ccaacgcggg
     3121 gaagaaggcg aaggacctca acgaggtcat ccgctacacc ctgtggtccg tcttcaagct
     3181 gaaggacgtg ctcccggaag accggacggg ctacgcggac gaggtccagg agctcttcga
     3241 ccagctggcc gcgaaggaca tcaccgtccg cggcacctac gacctctccg gcctgcgcgc
     3301 cgacgccgac atcatgatct ggtggcacgc ggagacggcc gacgagctgc agaccgcgta
     3361 caacctcttc cggcgcacca ggctgggccg cgccctggag ccggtgtggt cgaacatggc
     3421 cctgcaccgc ccggccgagt tcaacaagtc gcacatcccg gcgttcctcg ccgacgaggt
     3481 cgcccgcgac tacgtcagcg tctacccctt cgtgcgcagc tacgactggt acctgctgcc
     3541 cgacgaggac cgccgccgga tgctcgccga ccacggcaag atggcccgcg gctacccgga
     3601 cgtccgcgcc aacaccgtcg cctccttctc gctcggcgac tacgagtggc tgctggcctt
     3661 cgaggccgac gagctgcacc gcatcgtcga cctgatgcgc cacctgcgcg cctccgaggc
     3721 ccgtatgcac gtccgggaag aggtcccctt cttcaccggg cgccgcaagt ccgtcgccga
     3781 cctggtcgcc gggctcgcct gatacctccc ccggggggaa acagccggag gaatgacctc
     3841 ctccggcagc gggggaggcc ctgcccccga aacgacgcag ccggagaccc cgcaccggaa
     3901 gttcagactg ccggcggaag cgccccgggc ctggtgcccg gggcgcttcc gcccggtggt
     3961 ccagcgacac cggcgcgggc tccggatgcg gcggggccgg cctcacgagg aggagctgct
     4021 tgagcagctc gacgaggagg agctgcttga gcagctcgat ccgcccgaac tcccgcaccc
     4081 ggaaccgccc cagccgccgt cgccggagga cccgcagccc gagccgccgc ccgagccggc
     4141 gcaccacacg accggcaccg cctccgcccc ggacgacccg cagccgtcac tcccgccgcc
     4201 gccgccgccc gaacggcccg accggccgcc ctgcgcccgg tgctcggccg cggccagccg
     4261 cgcctgccgc gccgccggaa ccagcagcgg cccgaggtac gggtcccgca gcgtgcgcag
     4321 cccgaacagg gccgtctgcg cctgcggact gccgtcgccc acgtacacgg cgcgcatcgc
     4381 ccggagcgcc cgccgccccc gcggcgtgac acgccgcgcc gcccgcctcg cgcagaccgc
     4441 cccgaccacg gcgccggccg gcagcgcgaa cagcagcgac accccggccg gaaccccgcc
     4501 gccgcccgac accgcgagcg tgaacagcac cagcggcagc gacagcagga acagcacacc
     4561 gcacaccgcg gcctgcacca caccccacac ccgcacaccg cgcccccggc ccggcgcggt
     4621 cagcagcccg cgggccgcca gcccgtcccc gacctcctgc acggccggat cgcgcatggc
     4681 ggcgtaccgc acctgataaa gccggccgga cggcgcctgc ccgcaggcgc gcagcaccgc
     4741 ccgctcggcg gtgtcggcgg cgggggcgcc gggccgcgcc tgcacgatgc cggggccgcc
     4801 ggcggtcagg cggccgtccc cgaggagcac gacgagcgcg gtgtcgacga ccccgccggg
     4861 cccgcccgtg aggaacgccg cctccgacag gtccagcagc cgcggcggct ctccgccggt
     4921 acggggccgg gtgcgccgca gcgcccacac cagcagcacg ctggagacgg cgacgggcag
     4981 ccagacgacg gcgaacccgg tcacgccgcc ctccccgtga gggcgcgagc ccagcgcacg
     5041 atccgccccg gcggcttcgg cccggcgcgg tcccgccacc agacggtgag ccggcgccgc
     5101 gcggcggggt cggcgggcag gtcgcggacc agcaggtgct cggcgaagtc gagcgcgtcc
     5161 cgccggtagc cgccgggcag cggccggtgg cgcgcgtacc cgaggaacgc ctcccggaac
     5221 gccttccgcc cgccaagcag ctccggcagt tcgggcgcga ccttggcgac gatgtcggcc
     5281 cgcttggccg ccagcgcccg cgcctgcacc cgcacccgct gccggtcgaa cccctcgggc
     5341 acgggcgtcc cggcgacgag cgaggacagc agcgcggcct gctccaaccc cacccgggtc
     5401 cgcgcggcgg acagcccgcc ggcggccgcg cgagcgccgc gaacgccgcc gggcacggcg
     5461 ccggccggcg cgcccccgcc gcccaggacg ggcgccgccg cggcggcctc cagggtggag
     5521 cggatggccg cgaactcggc ggccagctcc ttctccggcg ggaaggcgtc gtctcgctcc
     5581 agcaggaccc cggccggccg catccggccc gccaggtccg ccaggatgtc gagcacggcc
     5641 ggcggcacgg ggtgggcgtg cgtgtcgtgc cacacgccgt cccgctcgac gccgcccgcg
     5701 acgtgcacgt acgccagcgc ctccggcggg accgccgcga gcaccgcggc cgggtcctcc
     5761 ccgcggttga cgcggttcgt gtggaggttc gccacgtcga tgagcagtcg gacgcccgtc
     5821 cgctcgacca gctccgtcag gaactgcgcc tccgtcagct cctcgcccgg ccagcgtacg
     5881 agcgcggcga tgttctccag cgccagcggc acgggcagcg cctcctgcgc gatccgcacg
     5941 ttctcgcaca gcacgtcgag cgcgtcccgg gtccgctgca cgggcagcag gtgcccggcc
     6001 tccagggccg gggaagcggt ccgtacgaag gcgatgtgct cggtgaccag cggcgccccc
     6061 aacgccaccg cccgctccgc gagcgcggcc agccggcccg cgtcgggcgg ctccgcaccg
     6121 ccgagcccga gcgacacccc gtgcgggacg acgcgcacac cgcggtcgag cagccgctgc
     6181 aacggctccg gcaggtggcc ggggcagatg ttctcggcga cgacctcgac ccagtccagg
     6241 ccgggcagcc gctcgaccgc atccgcgatc tccggccgcc acccgatgcc cactcccagc
     6301 tgcgccatgg ttcccgcgcc ctccccccgt tcgtcggccc ggcgtaccgg cccgtgtgcc
     6361 ggattgatgg ccccgcccac acggcgccaa cccagcgggg gtgacgttca gagcaacatt
     6421 tgaggttccg cccggcggga ggccgaagca cccgatgcgg gaccctccgg gcgccgcccc
     6481 tgcccgggcg ccgcccctgc ccgggcgccg cccctgcccg ggcgccgccc ctgcccgggc
     6541 agcgggccac ccgggctgcg gggggacggg tggtcggcga ccaccgtcgt ggagccgggg
     6601 gcggtatcgc tcacgcccgg gagaactctt gtactgcgat ttacatgatc caggggatag
     6661 cagctcgcgt cccgggttcc tgtactcgtc gacagcaggg tggggtgcac agcacacagg
     6721 gtgcgtctgc cggcggccat tgccgacggg atcggcgtct ccccccttgc cgagcgggta
     6781 cgcgagtagc cccggccggt cgtccctcct ccggccgggg ctggaccgcg aggggcagct
     6841 acccgacgac gaacccgcgg gcgggccgtc gggcgcgggc ggtcgccgcg gcggcgaggg
     6901 tcccggcggt gacgtcccgg cccgcgctgt cgaggacccg ccactctccg gccgggtctc
     6961 cggcatccac gggcgcgagc gtgccgggga tcccgtacgc ccgcatcgcg gcgtgcagct
     7021 cggctacgtc ttccgcgttc atgccctcac ctctcgttcg cgtgccgcga ctctattcgt
     7081 ccccgccgtg ggtggcgcac tggccgggac ggatcggccc gcacccgccc gggaccgggg
     7141 tgtgcgagca ggacgccgcc accgacacga gggaccgctc cggccccggc cccagctcgg
     7201 cgtccgggga gtacccggcc tgctcgatca gcgccacggt gcgggtcagg acgtcggggt
     7261 catggcggga ctcgtccggc cgctcggggt agtggtggac ggtccggccg agccggctgc
     7321 acagcgtcgc gtacaggtgg gtgtggagaa tgagggcgtg ccagccctcg tcgacctcgc
     7381 gggtcggggc gatccgcacc gtggggaaca ggctcgcggc gacgacgaac ttgagcacct
     7441 cgacgacgat gcgggtggcc atgtccgggg ccatgcccgg gttgttgtcg agcacggtgg
     7501 cgcggacgtc gttgaactgg gcgtcggtca gcaggcgcct cgggctgggg gcggcgccgc
     7561 ccgccggctt cacggtgcag ggcggcggag gggcgccggg aggggtgttg ttgcacgtca
     7621 tggggtctcc ttggtgtgag gtccgatggt gcaagggccc ggtcctgccc tgcgagggca
     7681 gggcggaccg ggagtctcag gggcgcgcga tgccgacggc gagggtgccg agggtgctga
     7741 ggacgatcag gacgtacagg gcttgccgtg cccgctcggt caccgcgccc gccgaggccg
     7801 gggtttcagc gggcggagcg ggtcgcggtc gcattccggg tgcacccaca tgtccggccg
     7861 ggcgcccgat gccgagtctc ggatgacgcg gatcgcgtcg ccgaacaccg gccgctggca
     7921 gacggcgcag atccgccccg ccgcggtcat cgcccggccg ccgggggcgg gcaggaccag
     7981 acgtcgacgt cgaggagcat cgggccgtcg tagccgagga tcgggccccg gtaaatgcgg
     8041 cccaggccga gcagcttgcc gcaggcgacg caggccttgc cgcgggcctg ctcgatcgtc
     8101 aggtcggaga acgccggcag cggcatgtcg gcgcatacgg tgccctgcgt cagcacgaga
     8161 ccagccgcat ctgtgtgacg gggatgacga actcgcgggc gtccgcgcca cggatgtacg
     8221 cggcgtcgta gcgcaggccg tactggttct cttcgacaca gacgtccatg agggtgccgc
     8281 acctgccgtc gaggaggtcc tgcacgtccc ggccgagcca ggcatgcggc acggacgtgc
     8341 cgacacgctc ggggctgggt gtcagggtgt agcgggctgc catggcggtg ctccctaccg
     8401 tcgtcagcgg gtggtgagag cagcgtagga ttcggcctgc gtcggccgaa gtgaccctca
     8461 gtacgggtac tttggacgca gtgcgcaggc tggaggggca gcatggacag caatgccacc
     8521 ggcaccctga cccgcggtca gggatcccaa catcgtcccc gcggcggcat agtgtccggc
     8581 tacgtttttc gcgtgatccg agagcagctg gaccacaccc aggagtccct ggccgaggtc
     8641 ttccatgtct cgccggatac cgtggctgga tgggagtcag gtcggcggcc tctcacgtca
     8701 ctggctgtcg gccagatgct ggtacaccgc caccggctca tgcgcatggg cgtgagccct
     8761 ggactgctcc ttgcgcttga gaaggcgttg gaagcggatg tcctactggc gagtgcgctc
     8821 actgacgacg ggcccacagg tgacagcccc cttggagcgt gggtgatgca gcgtgacctc
     8881 gtcgaggtgc tggcttggcc tttgaccggg gtaactccag agccgatgcg cgccctccag
     8941 gccccgtcaa agccaaggcg aggccccgcg cccagggggc cagaactatc agtgggcgac
     9001 cgccgccgat tcttccggtg catgcgccgg accgccgagg aggcggggcc gggccagttt
     9061 ctccgacgcc gtcaggccct ctacctcgcc gggtacgacg atgccccgga tacctcggaa
     9121 tggctcgcac agcagcagcg tgcagagcgg ccaggggact ggctcaccca gtggctcgct
     9181 gcccggtccg ttgccgcagt tgctgcccgc cagggcgatc gggaccgcat gcagcacttc
     9241 atctccacca cgctggacga tgacgcgggc gaagcagcaa acctgaacta ctgggcgtac
     9301 tggatcggcg aaagcacaca catccaaatc tcggacgact tcatcgccac gcacagcgcg
     9361 ccttggcatg gccacaagct gctccagcac ctcgtgaacg gcctcgtgcc gcatcagggc
     9421 ttcttcgacc tcaacctcca cactctctgg gccctgcttg ccgcgcgccc cactcttctg
     9481 cgtgcgacct ctgccacagg gcgcgccctc cgcgaccggc tccctgtgct gttggatggc
     9541 actgagccct ggacgcgcgc gcgtcgagag ctggaaggca tccggtacgc gatccgcctc
     9601 gccgaggcgt gaaggagaga tacagtggct gacgacctgt ccgcggtggc ccgcttcctc
     9661 tacgaagccg gcacgctcaa gcacacacgc cgcacgggct ggtggatggc tgggatcaat
     9721 gatccggaga gcgttgctga gcactcctgg cgtacctcgc tcatcgcgtc gatcatcgca
     9781 aagctggaag gcgctgaccc tgcgcgcgcc gcgttcctcg ccgtctggca cgacacccag
     9841 gagacccgca cgggggacgt gaaccacctc gggaagaagt acgcgtccag tgctgaccct
     9901 gaggctgtaa cggccgacca gacggccggc atgcccgaag tgctggcgtc tacgattcag
     9961 gatctggtcg ctgagtacga ggcgaagggc tctcccgaag cgatctgcgc acgtgacgcc
    10021 gacaagttgg agtgcatgct ccaaggcatc gagtacaagg cccaggggta ccaggccgca
    10081 cagcggtgga tcgacaacag ccgagcccgg ctcacgaccg agacggggca gaggctggca
    10141 gacgagctcc ttgggcaggg caccctcgac tggctgcggg cagccatcgg cgagacgaac
    10201 tgagcccaga cgcacgaaaa cgccccctcc cggcccgaag gccgagaggg ggcgctgtgc
    10261 agtggggcat cagttcccgg atcgcggcga cgatccggcg ggcgaggcac acgtgtccgg
    10321 cgtcggtcgg gtggacgccg tcgccgccga tgtaggcggt gatggcggag gtgatgaacg
    10381 gcccgtgcgt ggcgatcaag aagccggcgg cgtcgtagca gccgcccgtc agcgggctga
    10441 cgaacggaat cccatcagca gcagcggccg ctgtcacgta ttccgaggcg gggctgaagc
    10501 cgccgcccgg ggaggaggag gcggacaccg tccgcgaact cgtcgatccg gggaaggccg
    10561 acatggaccc gtcccgcggc atcctcgcgg ccggcgtctt ctcggccgcc ctggcgatcc
    10621 ccgcgtttcc cgatctcgcg ggcgccgaca ctcccgaccc ggtacggccc ggcaagggca
    10681 cggtccggat cgggcgggcg caggccgcct ccgtccgggc catgacggac cgcatcgccg
    10741 acttcctcgc ggcgcgctcg gtcggcgccc ggaaggcgta ggggctccgc cgggccggag
    10801 cggggcccct gtcgcgccgc cggagccggg cagcccgccc gccgccccgt cagaggcggg
    10861 agcggaggga cgggtggtcg gcgaccaccg tcgcggagcc gggggcgatc tcggtgaagc
    10921 ccgcgtcgcg gaccaccggg aggccgccgg tcgtgagggc cggccactgg tcgggggcgg
    10981 cggtgcggac ctccaggcgg aagccggagt cctgccaggc ggcgcgctcc gcggcggtca
    11041 ggtcccacca ggcgagctgc gccgcgtgcc cggcctgggc catggtcttg ccggcggaca
    11101 tctccaggtc cgggttgagc cacagcaccg gcacgcccgc ggtggcggcc ggcaccgggg
    11161 cggggtcgtc gaggtcggtg cccgacacct ggagtttggc gagctccttg ggccagccgt
    11221 ccagcgggac cggcgggaag acccgtacct gcgcggtgcc gccgtcgacc gtgatgccgg
    11281 gcagtgcgca cgccttgcgc cactccgc
//
