LOCUS       NZ_CP030862            12349 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces globosus strain LZH-48 chromosome, complete genome.
ACCESSION   NZ_CP030862
VERSION     NZ_CP030862.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globosus
  ORGANISM  Streptomyces globosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Draft genome Sequence of streptomyces globosus LZH-48
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Institute of Biophysics, Dezhou University,
            566 DaXuexi RD, Dezhou, Shandong 253023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Portal v. version 2.2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003325375.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:22:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,671
            CDSs (total)                      :: 6,576
            Genes (coding)                    :: 6,458
            CDSs (with protein)               :: 6,458
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 41 of 118
            Pseudo Genes (incomplete)         :: 101 of 118
            Pseudo Genes (internal stop)      :: 11 of 118
            Pseudo Genes (multiple problems)  :: 32 of 118
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:39:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1618299
            Orig. end                         :: 1630648
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030862.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..12349
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12349
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12349
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7349](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7349)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    259..273
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     misc_feature    759..773
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     gene            795..2954
                     /locus_tag="C0216_RS07555"
                     /old_locus_tag="C0216_07550"
     CDS             795..2954
                     /EC_number="3.6.4.12"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004982569.1"
                     /locus_tag="C0216_RS07555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_07550"
                     /product="RecQ family ATP-dependent DNA helicase"
                     /protein_id="WP_114054514.1"
                     /transl_table=11
                     /translation="MDDPDLRAEADAVLAELVGDPGGAARLREDQWQAVAALVRERRRA
                     LVVQRTGWGKSAVYFVATALLRRRGAGPTVIVSPLLALMRNQVEAAERAGIRARTINSA
                     NPEEWDSIHEEVERGATDVLLVSPERLNSVDFRDQMLPKLAATTGLLVVDEAHCISDWG
                     HDFRPDYRRLRAMLAELSPGVPVLATTATANARVTADVAEQLGTGAGEALVLRGPLERE
                     SLRLGVVRLPDAAHRLAWLAEHLDELPGSGIVYTLTVAAAEEATAHLRQRGFAVSSYTG
                     RTENADRLQAEADLLANRVKALVATSALGMGFDKPDLGFVLHLGSPSSPIAYYQQVGRA
                     GRGVEHADVLLLPGKEDEAIWRYFADTAFPPEAQVRQTLAALADAGRPLSVPALEAAVD
                     LRRSRLETMLKVLDVDGAVKRVKGGWTSTGQPWVYDAERYARVARQRAAEQQAMRDYVT
                     TDRCRMEFLRLQLDDAGAAPCGRCDNCAGPWADTAVSAETLTAAAKELDRPGVEIEPRR
                     MWPTGMPALGIDLKGRIPAGEQCSAGRALGRLSDIGWGNRLRPLLADGAPDGPVPDDVL
                     RAAVAVLADWARSPGGWAPDVPDASARPVGVVAVPSLTRPQLVDSLARGIASVGRLPFL
                     GTLDHTGPEGAYAARRSNSAQRLRGLSGAFAVPEELAAALQRSPGPVLLVDDSTDSGWT
                     LAVAARLLRRAGSGEVLPLVLAATG"
     gene            complement(2980..3636)
                     /locus_tag="C0216_RS07560"
                     /old_locus_tag="C0216_07555"
     CDS             complement(2980..3636)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018531615.1"
                     /locus_tag="C0216_RS07560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_07555"
                     /product="response regulator transcription factor"
                     /protein_id="WP_114054515.1"
                     /transl_table=11
                     /translation="MIQDAKIDRADGGLATVIRILLAEDMNMVRGALVALLEMEDDLEV
                     VSELERGDKILAAALEVRPDIAVIDIDLPGLDGLSAAAQLHEHLPECRTLMLTSLGRPG
                     TLRRALAAQVSGYILKDDSPKELASAIRRVVAGQRVIDSKLAVAAWNGLESPLTDRETE
                     VLRMAAQGSEAAEIAGELHLSTGTVRNYLTTVVMKLKARNRVDAIRIARDAGWLV"
     misc_feature    complement(3620..3634)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.4"
                     /tool="antismash"
     misc_feature    3621..3633
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 15.94"
                     /tool="antismash"
     misc_feature    3625..3638
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.1"
                     /tool="antismash"
     misc_feature    complement(3625..3641)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.53"
                     /tool="antismash"
     misc_feature    complement(3628..3641)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.57"
                     /tool="antismash"
     misc_feature    3628..3641
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.48"
                     /tool="antismash"
     misc_feature    3628..3644
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.22"
                     /tool="antismash"
     gene            complement(3683..4918)
                     /locus_tag="C0216_RS07565"
                     /old_locus_tag="C0216_07560"
     CDS             complement(3683..4918)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948909.1"
                     /locus_tag="C0216_RS07565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_07560"
                     /product="histidine kinase"
                     /protein_id="WP_114054516.1"
                     /transl_table=11
                     /translation="MSGRLKSSDDASEAVLFEGILRRSRDLPAPRMAKVTVVVALLCYV
                     GITTLNVLGAGVEGPALAAALFCLAAVFGLQLLHSRAGAKQAPAARRALTLGAQAALTY
                     LPLLALKSQWGAMAGFLAGSLLLLLPPRLGWSLYGFVGVSMLVPPLLDGRPVLDSVYLV
                     QTTLLTGLVTFGLTRLSELVHVLHESRDELTRAAVTRERLRFARDLHDLLGYSLSAIQL
                     KGELIHRLIPAHPAKAKKEIEDILAISRQSLADVRRVASGYRDLSLEEEIASARSVLSA
                     AEVEAVTDVRMGKVSAPVDTVLATVLREAVTNVLRHSRAAYCEITAVEEDGLMTLSVTN
                     DGVTDGYRDSSPHSGSGLGNLGLRLQAVGGELEVDRRPGNVFRVVARVPAQGAVDLDLE
                     GSPEGERTWLVA"
     gene            complement(5001..7349)
                     /locus_tag="C0216_RS07570"
                     /old_locus_tag="C0216_07565"
     CDS             complement(5001..7349)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003890.1"
                     /locus_tag="C0216_RS07570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_07565"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_114054517.1"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 3.5e-09,
                     bitscore: 35.1, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 3.3e-15,
                     bitscore: 54.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 4.9e-10, bitscore:
                     37.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 1.2e-90, bitscore: 303.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 1.4e-75, bitscore:
                     253.0, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAERGRPAAPPAAADRLVGFKSHLRPTVVPGDAAYLVSRRGVT
                     ALGGSQAEVLVPLLDGTRTAGAVRQEASRLLGAEDAEAALTALTDAGLIRATSPPAATA
                     AGGVPAPGAAEAEAYWDLAGLDGGLASADLSRASAAIEALPGLDPAPVAEACRASGVAV
                     AGDADGASLVLVLCDDYLSPGLAAADAAHRAAGRPWLPVRLCGTEPWVGPFFRPDTGPC
                     WHCLAVRLRGHRHSELPVGRALGLDGPVPRPPAGLAAGTALAVNLAVLEAAKWLAGLRN
                     PEQGHLHTFDTLRLRTSGHRVDRLPQCPACGDPGLVARRVHAPFVPASRPKAPAAAGGN
                     GDRALTPAQLLAAYGHLVDPVTGVVKEIRRAPGTPDDAHAYTSGHNLAMASATLAGLRS
                     GLRALSGGKGRTAEEARAGALCEAVERYSGTRHGDEPTVRDSLRGLGAAAVHPDDCLLY
                     SARQYAERDLWNARASRFHYVSAPFDETRPTDWTPVWSLTGGVQRLLPASMLYFARGDG
                     RAPAPHPDDPWADSNGNAAGSSPEDALVQGFMELVERDAVALWWYNRTRQPAVDLDAFA
                     DDWTERIRRGLRRAGREAWALDLTSDLGIPVVAALSRRTDKPGEDVVFGFGAHFDPGVA
                     LRRALSEMAQLLPAVRDARPDGTGYRIGDPEPLSWWRNATVGNQRYLAADPAAAPRTPA
                     DWPAVRTADLLDDVQTITELVRRKGMDLLVLDQTRPDLGIPVTKVVVPGLRHFWPRFAP
                     GRLFDVPVELGRLAEPTPYDQLNPIPLFV"
     aSDomain        complement(7029..7298)
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C0216_RS07570_Goadsporin_CD_RRE.1"
                     /evalue="1.50E-17"
                     /identifier="RREFam013.1"
                     /label="C0216_RS07570"
                     /locus_tag="C0216_RS07570"
                     /protein_end="107"
                     /protein_start="17"
                     /score="54.5"
                     /tool="antismash"
                     /translation="RLVGFKSHLRPTVVPGDAAYLVSRRGVTALGGSQAEVLVPLLDGT
                     RTAGAVRQEASRLLGAEDAEAALTALTDAGLIRATSPPAATAAGG"
     aSDomain        complement(7047..7292)
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C0216_RS07570_NHLP_CD_RRE.1"
                     /evalue="2.30E-12"
                     /identifier="RREFam015.1"
                     /label="C0216_RS07570"
                     /locus_tag="C0216_RS07570"
                     /protein_end="101"
                     /protein_start="19"
                     /score="37.8"
                     /tool="antismash"
                     /translation="VGFKSHLRPTVVPGDAAYLVSRRGVTALGGSQAEVLVPLLDGTRT
                     AGAVRQEASRLLGAEDAEAALTALTDAGLIRATSPPA"
     aSDomain        complement(7068..7298)
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C0216_RS07570_Cyanobactin_D_RRE.1"
                     /evalue="1.60E-11"
                     /identifier="RREFam007.1"
                     /label="C0216_RS07570"
                     /locus_tag="C0216_RS07570"
                     /protein_end="94"
                     /protein_start="17"
                     /score="35.1"
                     /tool="antismash"
                     /translation="RLVGFKSHLRPTVVPGDAAYLVSRRGVTALGGSQAEVLVPLLDGT
                     RTAGAVRQEASRLLGAEDAEAALTALTDAGLI"
     gene            complement(7346..7540)
                     /locus_tag="C0216_RS07575"
                     /old_locus_tag="C0216_07570"
     CDS             complement(7346..7540)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C0216_RS07575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C0216_07570"
                     /product="hypothetical protein"
                     /protein_id="WP_114054518.1"
                     /transl_table=11
                     /translation="MTSIPASARTTVNGSAPAPAHSARPGLVIEHLDALPDTQHALFTV
                     CAVTQLAEPAAPAAGPQGA"
     gene            complement(7725..8921)
                     /locus_tag="C0216_RS07580"
                     /old_locus_tag="C0216_07575"
     CDS             complement(7725..8921)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010064117.1"
                     /locus_tag="C0216_RS07580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_07575"
                     /product="cytochrome P450"
                     /protein_id="WP_114054519.1"
                     /sec_met_domain="p450 (E-value: 2.5e-19, bitscore: 67.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHTEIAADFAALGEDFTRDPYPVYAALRARGPVHRIRTPEGAEAW
                     LVVGHEACRAALTHPGLSKSWRDASPGLPLARLSAGENLLSSNPPDHTRLRRLVAGEFT
                     PRRVEGLAPRVRELAGGLLGAMLARPDRRADLVEALAFPLAMGVICELLGVPALDRASF
                     RDWAGQALSSPDREVRTAATAAMTRYLVGMVEEMRARPGADLMSALIRTTDEDGGRLSA
                     DELIGMAWLLLVTGFETTVNLIATGVLLLLRHPDQLAALRADPALAGGAVEEVLRYEGP
                     VETTTYRFTTGPVEIGGAAIPGGGELVLVALADADRDPARFTDPDRFDIRRPAGGHIAF
                     GHGIHYCLGAPLARLQARTALCALLERAPGLRLDADPASLPWRAGLLIRGPRSLPVRW"
     gene            complement(9004..9954)
                     /locus_tag="C0216_RS07585"
                     /old_locus_tag="C0216_07580"
     CDS             complement(9004..9954)
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018556337.1"
                     /locus_tag="C0216_RS07585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_07580"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_114054520.1"
                     /transl_table=11
                     /translation="MNASRKTAEFSRRTTLTGGALVGIGLAEGLLGAAPAAAAGAPAAG
                     AAAAADAAAAGRNSRYARGLAVLRETSGERGTAVVESLKDIAPDLGRFVVEFAYGDIYP
                     RAGLDLRERELVTLGALTAQGDTAPQLNFHIDAALHVGVKPAEVVEALIHLVPFMGFPR
                     ALNAIGVARTVFADRGVAFRPPVMNDARDRYRRGVDKLVEIDGRHGLEVVESLKDIAPD
                     LGRFIVEFTFGDVYHRPWLSPRRRQLVTVGALTAFGDTAPQLRVHIGAALNVGLSPAQV
                     VEALIHVVPYAGFPRVLNAITVAREVFEKRKTSVS"
     misc_feature    10004..10019
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.83"
                     /tool="antismash"
     misc_feature    10028..10043
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.92"
                     /tool="antismash"
     misc_feature    10033..10042
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 12.73"
                     /tool="antismash"
     misc_feature    10035..10049
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(10040..10891)
                     /locus_tag="C0216_RS07590"
                     /old_locus_tag="C0216_07585"
     CDS             complement(10040..10891)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133232.1"
                     /locus_tag="C0216_RS07590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_07585"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_114054521.1"
                     /sec_met_domain="PCMT (E-value: 1.1e-05, bitscore: 23.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTADHAGWGYTASTGLAFTHGEIVDQHFEACAGHYREALHGVGL
                     RPGWQVLDAGCGSGAFLPLIAELVGPEGGVCAVDLAAENAARAAARMRAHPARARVEVR
                     QGSVLDLPYEDGAFDAVWCANTTQYLDDGELAQALSELRRVTRPGGLVAVKDVDGTLST
                     VRPADPFLITDFFRWSAASPGYARQLLRGRDLHRWLRAAGLEAVRQRTLLMEHHAPLPP
                     AAFRFYGNACARFALQAAAEGAPGNWAPFLDPADPAHPLRDPDGYISEGNALAIGTVPK
                     TP"
     gene            complement(10885..11715)
                     /locus_tag="C0216_RS07595"
                     /old_locus_tag="C0216_07590"
     CDS             complement(10885..11715)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (22-254). E-value:
                     4.8e-28. Score: 90.3. Matches aSDomain:
                     nrpspksdomains_C0216_RS07595_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138111.1"
                     /locus_tag="C0216_RS07595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_07590"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_246042365.1"
                     /sec_met_domain="PF00561 (E-value: 3.4e-23, bitscore: 81.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.4e-18, bitscore:
                     64.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAAVHADAPGAGRPRAEDAGGPPVVLLHALPFDASMWEGPAREL
                     RARGHRVLAVDQPGFGAAPAAQGPPSLDSVADALAAELDRQGIGSAVLAGCSLGGYTAM
                     AFLRRHPHRVRGLALLAARGTADTAQAAEQRLRFADAFLDDAARGRLVAQTTPSLLGAT
                     TRRRRPDLLDRVTGLALAAPPQSVAWTQRALAARPDSTAVLRAAAVPALVVLGGEDELV
                     AAAEARPVAAALPQGRLAVLPGVGHLAPLEAPRETARLLAGLLARAGKAGAGAW"
     aSDomain        complement(10954..11649)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C0216_RS07595_Abhydrolase_1.1"
                     /evalue="4.80E-28"
                     /label="C0216_RS07595_Abhydrolase_1.1"
                     /locus_tag="C0216_RS07595"
                     /protein_end="254"
                     /protein_start="22"
                     /score="90.3"
                     /tool="antismash"
                     /translation="PPVVLLHALPFDASMWEGPARELRARGHRVLAVDQPGFGAAPAAQ
                     GPPSLDSVADALAAELDRQGIGSAVLAGCSLGGYTAMAFLRRHPHRVRGLALLAARGTA
                     DTAQAAEQRLRFADAFLDDAARGRLVAQTTPSLLGATTRRRRPDLLDRVTGLALAAPPQ
                     SVAWTQRALAARPDSTAVLRAAAVPALVVLGGEDELVAAAEARPVAAALPQGRLAVLPG
                     VGHLAPLEAP"
     CDS_motif       complement(11320..11418)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C0216_RS07595_0001"
                     /evalue="3.30E-01"
                     /label="PKSI-DH_m2"
                     /locus_tag="C0216_RS07595"
                     /protein_end="132"
                     /protein_start="99"
                     /score="3.8"
                     /tool="antismash"
                     /translation="GYTAMAFLRRHPHRVRGLALLAARGTADTAQAA"
ORIGIN
        1 cagcgcaggc cgtgcagggt gcaggcgtcg cgcagccccc acatccaggc gccgtcctcc
       61 tcggtccacc gctcgtcgcc gtcgcggcag tacatcagca ccgcagtccg caccggggtc
      121 cggcggcgca ggtcgtgcgg gatcacccgg cgcagggcgg ccagcagcgc gttgcggtag
      181 tcccagccgt cgccggacgc ggcccgctgg acgaacgacg cactcgcgac gaggtcctcc
      241 tcggggccca ggacggctat caccgcggtc gacggcgcgg ggccgtgccg tgagtgcagg
      301 ccgctgacga gttcgcgcgg gttgcccagc agcggaatgc cggccgccgt ccactcggcg
      361 ggctccagca gtcttccgtg ccggctgctg ccgccggccg tcgtagtcag agacgcggtc
      421 gagggcgggg cgaatccgaa ggccacggtc ctcccttcgg gtacacgccc gcggacgggc
      481 acggctggag tgggggcgcg ccgcagcacg gcccaggggg tgccgtcgag ccgagcggga
      541 gcactccgat tctcgcgtgg gccgagagca tgcggcaacg agcaattgcg accgccgacc
      601 ggaattcgcc ggtatgccgt tcatatcctt gcccagccgc gctgacggcg actcatgcgg
      661 ccgcagccga gcggcccgtc gccctgcgcg ctgccctccc gcggcccgcg gcaaaccggc
      721 cgccaccctc cgcatgcggg gtgtcgcccg gagtgaactg gccgaccggc ccctgcatcc
      781 ggttgcatgg gggtatggac gatcccgacc tgcgcgccga agccgatgcc gtactcgccg
      841 agctggtggg cgacccgggg ggcgccgcgc ggctgcgcga ggaccagtgg caggcggtcg
      901 ccgccctcgt acgggagcgc cggcgggccc tggtcgtgca gcgcaccggc tggggcaagt
      961 ccgcggtcta cttcgtggcg accgccctgc tgcgccgccg cggcgccggg cccacggtga
     1021 tcgtctcccc gctgctggcc ctgatgcgca accaggtcga ggccgccgag cgggccggca
     1081 tccgcgcccg caccatcaac tccgccaacc ccgaggagtg ggactccatc cacgaggagg
     1141 tcgagcgcgg cgccaccgac gtcctcctcg tcagccccga acgcctcaac tcggtcgact
     1201 tccgcgacca gatgctcccc aagctcgccg ccaccaccgg cctcctcgtc gtcgacgaag
     1261 cgcactgcat ctccgactgg gggcacgact tccggcccga ctaccggcgg ctgcgggcca
     1321 tgctcgccga gctctccccc ggggtgccgg tcctggccac caccgcgacc gcgaacgccc
     1381 gcgtcaccgc cgacgtcgcg gagcagctcg gcaccggcgc cggcgaggcc ctcgtactgc
     1441 gcggaccgct ggagcgggag agcctgcgcc tgggcgtcgt ccggctgccc gacgccgcgc
     1501 accgcctggc ctggctcgcc gagcacctcg acgagctgcc cggctccggg atcgtgtaca
     1561 cgctgaccgt ggcggcggcc gaggaggcca ccgcccacct gcggcagcgc gggttcgccg
     1621 tctcctcgta cacggggcgg acggagaacg ccgaccgcct ccaggcggag gccgacctgc
     1681 tggccaaccg ggtcaaggcg ctcgtcgcga cgtcggccct cggcatgggc ttcgacaagc
     1741 cggacctcgg cttcgtcctc cacctcggct ccccgtcctc gccgatcgcc tactaccagc
     1801 aggtcgggcg cgccggccgc ggcgtcgagc acgccgacgt gctgctgctg cccggcaagg
     1861 aggacgaggc catctggcgg tacttcgccg acaccgcctt cccgcccgag gcgcaggtgc
     1921 ggcagaccct cgcggccctc gccgacgccg gccggcccct gtccgtaccg gccctggagg
     1981 ccgcggtgga cctgcggcgc agcaggctgg agaccatgct gaaggtcctc gacgtcgacg
     2041 gcgccgtcaa gcgcgtgaag ggcggctgga ccagcaccgg gcagccgtgg gtgtacgacg
     2101 ccgagcgcta cgcgcgggtc gcccgccagc gggccgccga acagcaggcc atgcgcgact
     2161 acgtcaccac cgaccggtgc cggatggagt tcctccgcct ccagctggac gacgcggggg
     2221 cggccccctg cggccgctgc gacaactgcg ccggcccctg ggccgacacc gcggtctccg
     2281 cggagacgct gaccgccgcc gccaaggagc tcgaccgccc cggcgtggag atcgagccgc
     2341 gccgcatgtg gcccaccggc atgcccgccc tcgggatcga cctcaagggc cggatcccgg
     2401 ccggcgagca gtgctcggcc gggcgcgccc tcggccggct ctccgacatc ggctggggca
     2461 accggctgcg ccccctcctg gcggacggcg cccccgacgg gcccgtcccc gacgacgtgc
     2521 tgcgcgccgc cgtcgcggtc ctcgccgact gggcgcgctc gccgggcggc tgggcgcccg
     2581 acgtcccgga cgcctcggcc cggccggtcg gcgtcgtcgc cgtgccgtcc ctgacccgcc
     2641 cgcagctcgt cgactcgctc gcccggggca tcgcctccgt cggccgcctg ccgttcctgg
     2701 gcaccctcga ccacaccggc ccggagggcg cgtacgcggc acgccgcagc aactccgcgc
     2761 agcggctgcg gggcctgtcg ggggccttcg cggtccccga ggagctggct gccgcgctgc
     2821 agcggtctcc cggccccgtc ctcctcgtgg acgacagcac cgactccggc tggacgctcg
     2881 ccgtggcggc ccgcctgctg cggcgggcgg gcagcggcga ggtcctcccg ctcgtcctcg
     2941 ccgccaccgg ctgacggggc ccgcgggccc cgcggccggt cagaccagcc agcccgcgtc
     3001 gcgcgcgatg cggatggcgt cgacccggtt gcgggccttc agcttcatca ccacggtcgt
     3061 caggtagttg cgcaccgtcc ccgtggagag gtgcagctcg ccggcgatct ccgccgcctc
     3121 cgagccctgc gcggccatgc gcagcacctc ggtctcccgg tcggtgagcg ggctctccag
     3181 gccgttccag gcggcgacgg cgagcttgga gtcgatcacc cgctgcccgg ccaccacgcg
     3241 gcggatggcg ctggcgagct ccttggggga gtcgtccttg aggatgtatc cggacacctg
     3301 cgcggcgagc gcccggcgca gggtgccggg gcggccgagg ctggtcagca tcagcgtgcg
     3361 gcactccggc aggtgctcgt gcagctgcgc cgccgcgctg aggccgtcga ggccggggag
     3421 gtcgatgtcg atgaccgcga tgtccggccg gacctccagt gccgcggcca ggatcttgtc
     3481 gccgcgctcc agctcgctga cgacctccag gtcgtcttcc atttcgagca gggcgacgag
     3541 cgcgccgcgc accatgttca tgtcttcggc cagcaggatt ctgatcaccg ttgcgagccc
     3601 cccgtccgcg cggtcgatct ttgcatcttg aatcataaca accgtcccac ggccggtcgg
     3661 cagggcgtga cgcggggtca gctcacgcga ccagccaggt gcgttcgcct tccggcgacc
     3721 cctccaggtc caggtcgacc gccccctggg cggggacccg cgcgaccacc cggaagacgt
     3781 tgccgggacg gcggtcgacc tccagctccc cgccgaccgc ctggaggcgc agacccaggt
     3841 tccccaggcc gctgccgctg tgcggggagg agtcccggta cccgtcggtg acgccgtcgt
     3901 tcgtgaccga cagcgtcatc aggccgtcct cctcgacggc cgtgatctcg cagtacgccg
     3961 ccctgctgtg ccgcagcacg ttggtgacgg cctcccgcag cacggtggcc aggaccgtgt
     4021 ccaccggagc gctgaccttc cccatccgca cgtcggtgac cgcctcgacc tcggcggcgc
     4081 tcagcaccga ccgcgccgag gcgatctcct cctccagcga caggtcccgg tagccgctcg
     4141 ccacccgccg cacgtccgcc agggactgcc gggagatcgc caggatgtcc tcgatctcct
     4201 tcttggcctt cgccggatgc gccggtatca ggcggtggat cagctcgccc ttgagctgga
     4261 tggcggacag gctgtatccg agcaggtcgt gcaggtcgcg ggcgaagcgg agccgctcgc
     4321 gggtgaccgc cgcgcgcgtc agctcgtccc ggctctcgtg caggacgtgc accagctcgg
     4381 acaggcgggt gagcccgaag gtgaccagcc ccgtcagcag tgtggtctgc accaggtaca
     4441 cgctgtcgag gacgggccgc ccgtccagca gcggcggaac gagcatgctg acgcccacga
     4501 agccgtacag ggaccagccc aggcgcggcg gcaggagcag cagcagggag ccggcgagga
     4561 accccgccat ggccccccac tgcgacttca gcgcgagcag cggcaggtag gtcagggccg
     4621 cctgcgcgcc cagtgtcagc gcccggcgcg ccgcgggggc ctgcttggcg ccggcacggg
     4681 agtgcagcag ctgcagaccg aagaccgcgg ccaggcagaa cagggcggcc gccagggccg
     4741 ggccctccac cccggcgccc aggacgttca gggtggtgat gccgacgtag cagaggagcg
     4801 cgacgaccac ggtgaccttg gccatccgcg gcgccggcaa gtcccggctg cgccgcagaa
     4861 tcccctcgaa caggaccgcc tccgatgcgt catccgagga cttgaggcgg ccagacatgt
     4921 caatcccccc atgggcgttc cgtgttgcag ccaccttgag cataggcgag gaagtcgggc
     4981 aggcgctgaa atccgatcgc tcacacgaac agagggatgg gattgagctg gtcgtacggt
     5041 gtgggttcgg ccagtctgcc gagttccacg ggcacgtcga atagccggcc gggagcgaat
     5101 ctcggccaaa agtgacgcag tcccggtacg accactttcg ttaccggaat ccccaggtcc
     5161 ggccgtgtct ggtccaggac caacaggtcc atgcctttcc gccggaccaa ctccgtgatc
     5221 gtctgtacgt cgtccagcag gtccgcggta cggaccgccg gccagtcggc gggagtccgc
     5281 ggcgccgccg caggatcggc cgccaggtac cgctggttcc cgacggtcgc gttccgccac
     5341 cacgacagcg gctccgggtc gccgatccgg taccccgtgc cgtccggccg ggcgtcccgc
     5401 accgcgggca gcagctgggc catctccgac agcgcccggc gcagcgcgac ccccgggtcg
     5461 aagtgcgcgc cgaagccgaa caccacgtcc tcgcccggct tgtcggtgcg ccgggacagc
     5521 gccgcgacca ccggtatccc caggtccgag gtgaggtcga gcgcccacgc ctcccggccc
     5581 gcccgccgca gcccgcggcg gatccgctcg gtccagtcgt cggcgaacgc gtccaggtcg
     5641 accgccggct ggcgggtgcg gttgtaccac cacagggcca ccgcgtcccg ctccaccagc
     5701 tccatgaacc cctgcaccag cgcgtcctcg gggctgctgc cggccgcgtt gccgttggag
     5761 tcggcccacg ggtcgtccgg gtgcggggcc ggagcccggc cgtcgccgcg ggcgaagtac
     5821 agcatcgagg ccggcagcag ccgctgcacg cccccggtca gcgaccacac cggcgtccag
     5881 tcggtgggcc gcgtctcgtc gaacggcgcc gacacgtagt ggaagcggga ggcacgggcg
     5941 ttccacaggt cgcgctccgc gtactggcgg gcgctgtaga gcaggcagtc gtcggggtgg
     6001 acggccgccg cgcccaggcc gcgcagcgag tcgcggaccg tcggctcgtc gccgtgccgg
     6061 gtgccgctgt agcgctcgac cgcctcgcac agcgcgcccg cgcgggcctc ctcggcggtg
     6121 cggcccttgc cgccgctgag cgcgcgcagg cccgagcgga gcccggccag ggtcgccgac
     6181 gccatggcca ggttgtggcc ggaggtgtag gcgtgggcgt cgtccggggt gccgggcgcc
     6241 cgccggatct ccttgaccac cccggtcacc gggtcgacga ggtgcccgta cgcagccagc
     6301 agctgcgcgg gcgtgagcgc ccggtccccg ttccctccgg cggcggccgg ggccttgggc
     6361 cgggaggcgg ggacgaacgg ggcgtgcacg cggcgggcga cgaggccggg gtcgccgcac
     6421 gcagggcact ggggcagccg gtccacccgg tggccggagg tgcgcagccg cagcgtgtcg
     6481 aaggtgtgga ggtggccctg ctcggggttg cgcaggcccg cgagccattt cgccgcctcc
     6541 aggacggcga ggttcaccgc gagggccgtc ccggcggcca gcccggccgg gggccgcgga
     6601 acgggcccgt ccaggccgag cgcgcggcct acgggcagct cggagtggcg gtggccgcgc
     6661 agccggacgg ccaggcagtg ccagcagggg ccggtgtccg gccggaagaa cgggcccacc
     6721 cagggttcgg ttccgcagag ccggaccggc agccacggcc ggccggccgc gcggtgggcg
     6781 gcgtcggccg cggcgaggcc gggggagagg tagtcgtcgc acaggacgag gaccagggag
     6841 gcgccgtccg cgtcgcccgc gacggccacg ccggaggccc ggcaggcctc cgcgacgggt
     6901 gccgggtcga gtccgggcag ggcctcgatc gcggcggacg cccgggacag gtcggcggag
     6961 gccaggcctc cgtccagccc ggccaggtcc cagtaggcct cggcctcggc agcgccgggc
     7021 gcggggaccc cgccggccgc ggtggcggcc ggcggggagg tggcgcggat cagtccggcg
     7081 tcggtgaggg cggtgagggc cgcttcggcg tcctccgctc ccaggaggcg ggaggcctcc
     7141 tgccggaccg cgcccgcggt gcgggtgccg tcgaggagcg gaacgagtac ctccgcctgg
     7201 ctgcctccca gcgcggtcac tccgcgccgg gacaccaggt aggcggcgtc gccgggcacg
     7261 accgtcggcc gcaggtggga cttgaagccc accaggcggt ccgcggccgc cggaggcgcg
     7321 gccggccgcc cgcgctcggc agtgctcatg cgccctgcgg tccggcggcc ggggctgccg
     7381 gctcggccag ctgcgtcacg gcgcagaccg tgaacagcgc gtgctgggtg tcgggcaggg
     7441 cgtcgaggtg ttcgatcacg aggcccgggc gggcggagtg ggcgggggcc ggtgcggatc
     7501 cgttgacggt ggtgcgggca ctggccggaa tgctggtcat ggtggtcagg ttccctctgc
     7561 gttgtcgtct ggcgggtttc gatccgttca tgaacgattc tgcgagggaa caggcgaccg
     7621 cagacagtgc tgccgtcacc atcacgggat gaagatttca catcgaccgg tggcatgacc
     7681 accggccggg cgccccgagt gctgccggaa cgtcaggctc cgccctacca gcggacgggc
     7741 aggctgcggg gaccgcggat gaggagcccc gcccgccacg gcagcgacgc cgggtcggcg
     7801 tccaggcgca gcccgggggc gcgctccagc agtgcgcaca gggccgtgcg cgcctggagc
     7861 cgggccagcg gggcgcccag gcagtagtgg atgccgtggc cgaatgcgat gtggccgccc
     7921 gccggccggc ggatgtcgaa gcggtccgga tccgtgaacc gcgccgggtc gcggtcggcg
     7981 tcggcgagcg cgaccagcac cagctcgccg ccccccggga tggcggcccc gccgatctcc
     8041 acgggacccg tcgtgaaccg gtacgtggtg gtctcgaccg gcccctcgta gcgcaggacc
     8101 tcctccacgg ccccgcccgc cagcgcgggg tccgcgcgca gtgcggcgag ctggtcgggg
     8161 tggcgcagga gcagcaggac gcccgtcgcg atgaggttga cggtggtctc gaagccggtg
     8221 acgagcagca gccaggccat gccgatgagc tcgtccgcgg agagccggcc gccgtcctcg
     8281 tccgtggtcc ggatcagtgc gctcatcagg tcggcgccgg gccgggcccg catctcctcc
     8341 accatgccga ccaggtaccg cgtcatcgcg gcggtggcgg ccgtacgcac ctcgcggtcc
     8401 gggctgctca gcgcctgccc ggcccagtcc cggaaggacg cgcggtccag ggcgggcacg
     8461 ccgaggagct cgcagatcac gcccatcgcc agcgggaacg ccagggcctc gacgaggtcg
     8521 gcccgccggt ccggccgggc gagcatcgcg ccgaggagcc cgcccgccag ctcccgcacc
     8581 cggggggcca gcccctcgac gcgccgcggc gtgaactccc cggccaccag ccgccgcagc
     8641 cgggtgtggt cgggcgggtt cgagctcagc aggttctcgc ccgccgagag ccgggccagc
     8701 ggcagcccgg gcgaggcgtc ccgccacgac ttcgacaggc ccgggtgggt gagcgcggcc
     8761 cggcaggcct cgtgcccgac gacgagccag gcctcggcgc cctcgggcgt gcggatccgg
     8821 tgcaccgggc cccgcgcgcg cagggccgcg tacaccgggt acgggtcgcg ggtgaagtcc
     8881 tcgccgagcg ccgcgaagtc cgccgcgatc tccgtgtgca tgctgcctgc cgttcccttt
     8941 gtcggacggt gttgcggcgg cggccccggc ccgcgcggtc ggcgcgcggg cggggcccgg
     9001 cccctacgag acggaggtct tccgcttctc gaacacctcg cgcgccaccg tgatggcgtt
     9061 cagcacccgc gggaagcctg cgtacggcac cacgtggatc agcgcctcca cgacctgcgc
     9121 cgggctcagg ccgacgttca gcgcggcgcc gatgtgcacg cgcagctgcg gggcggtgtc
     9181 gccgaacgcg gtgagcgcgc cgaccgtgac gagctggcgc cgccgcggcg acagccacgg
     9241 ccggtggtag acgtcgccga aggtgaactc gacgatgaac cgccccaggt cgggcgcgat
     9301 gtccttcaga gactcgacga cctccagacc gtgccggccg tcgatctcca ccagcttgtc
     9361 gacaccgcgc cggtagcggt cgcgggcgtc gttcatgacc ggcggccgga aggccacgcc
     9421 gcggtcggcg aacaccgtcc gggcgacgcc gatcgcgttc agcgcccgcg ggaaccccat
     9481 gaagggcacc aggtggatca gcgcctcgac cacctcggcc ggcttcacgc cgacgtgcag
     9541 cgctgcgtcg atgtggaagt tcagctgcgg cgccgtgtcg ccctgggcgg tcagcgcgcc
     9601 cagcgtcacg agctcccgct cgcgcaggtc cagaccggcc cgcgggtaga tgtcgccgta
     9661 cgcgaactcg accacgaagc gcccgaggtc gggggcgatg tccttcagcg actcgaccac
     9721 ggcggtcccg cgctcgcccg aggtctcgcg cagcacggcg agcccgcgcg cgtagcggga
     9781 gttcctgccc gcggcggcgg cgtccgcggc cgcggcggct ccggccgccg gggcgccggc
     9841 ggccgccgcc ggagccgcgc ccagcaggcc ctcggcaagg ccgattccga ccagggcgcc
     9901 cccggtcagg gtggtgcggc gggagaattc cgcggtcttt cgcgatgcat tcatgacgtc
     9961 tcgatccatt cgataggggt cggctgtggg ggagggaatc gggtcgaatt cctcttccgc
    10021 cgagaagagg acggtttttt cagggagttt tcggaaccgt gccgatcgcg agggcgttgc
    10081 cctcgctgat gtatccgtcc ggatcgcgca gcggatgggc cggatccgcc gggtccagaa
    10141 aaggcgccca gttccccggg gcgccttcgg ccgccgcctg cagggcgaaa cgcgcgcacg
    10201 cgttcccgta gaagcggaag gccgccggcg ggagcggcgc gtggtgctcc atcagcagcg
    10261 tgcgctgccg caccgcctcc aggccggccg cgcgcagcca ccggtggagg tcccggccgc
    10321 gcagcagctg gcgggcgtac ccgggggagg cggccgacca ccggaagaag tcagtgatca
    10381 ggaaggggtc cgccgggcgc accgtgctca gcgtgccgtc cacgtccttc acggcgacga
    10441 gcccgcccgg cctggtgacc cggcgcagct ccgacagcgc ctgcgccagc tccccgtcgt
    10501 cgaggtactg cgtcgtgttc gcacaccaca ccgcgtcgaa cgcgccgtcc tcgtacggca
    10561 ggtcgaggac gctgccctgc cgcacctcca cgcgggcccg cgcggggtgc gcccgcatcc
    10621 gcgcggctgc ccgcgccgcg ttctccgcag ccaggtccac ggcgcacacg cccccttccg
    10681 ggccgacgag ctccgcgatc agcggcagga aggcgccgct gccgcagccg gcgtcgagca
    10741 cctgccagcc gggccgcagg cccacgccgt gcagcgcctc ccggtagtgg ccggcgcacg
    10801 cctcgaagtg ctggtcgacg atctccccgt gcgtgaacgc gagccccgtg gaggcggtgt
    10861 acccccaccc cgcgtggtcg gccgtcacca tgcgccggca cccgcctttc cggcacgggc
    10921 gagcagcccg gcgaggagcc gcgccgtctc ccgcggggcc tccagcgggg cgaggtggcc
    10981 cacgccgggg aggacggcga gccggccctg cggcagcgcc gcggcgaccg gccgcgcctc
    11041 cgctgctgcg accagctcgt cctcgccgcc gaggacgacg agggcgggca ctgcggccgc
    11101 gcgcaggacc gccgtggaat cggggcgcgc cgcgagggcc cgctgtgtcc aggcgaccga
    11161 ctgcggcggg gccgccagcg ccaggcccgt cacccggtcg aggaggtccg gccgccggcg
    11221 acgcgtcgtg gcgcccagca gcgacggagt ggtctgcgcc acgagcctcc cgcgcgcggc
    11281 gtcgtcgagg aacgcgtcgg cgaagcgcag gcgctgctcg gcggcctgcg cggtgtcggc
    11341 ggtgccgcgg gcggccagca gggccaggcc gcggacccgg tgcgggtggc ggcgcaggaa
    11401 cgccatggcc gtgtagccgc ccagggagca gccggccagg acggcggagc cgatcccctg
    11461 ccggtcgagc tccgcggcga gcgcgtccgc caccgagtcc agcgacggcg gcccctgcgc
    11521 cgcaggcgcg gcgccgaagc cgggctggtc gacggcgagg acgcggtggc cgcgggcgcg
    11581 cagctcccgc gcggggccct cccacatgga cgcgtcgaac ggcagggcat ggaggaggac
    11641 caccggcggg ccgccggcgt cctccgcgcg cgggcggccc gccccgggcg cgtccgcgtg
    11701 cacggccgcg ctcaccgctg caccgcccgt tccgcggcgg cgacgaaccg cgcgacgtgc
    11761 tccggctgtt cgacgccgcg cagccggccg aaggcgaccg gcgacggcgg gaggtcgtgc
    11821 accgggacga cctcgatgtc cggcgggagg acggccgcca gcgaccggaa cgagacgtgc
    11881 accgccgggc tgctgcgcag cagctccgcg agcgcgccga gagtggtcat cgggtggacg
    11941 cggcggatcg tgcggccccc cggggtgcgc ggcggcacca ccaggtccca cacgtgcgcg
    12001 gggaagctgc cggggcaccg gaacgcctcg tagtccgcga cctcctcgat cgacacctcc
    12061 ccgcggccgg cgagcgggtg gccggcgccg accagcacgg cccgcccgtc gaaggcgacg
    12121 ggcgcgctga cggcgatgtc cggctccagc gggtcgtact tgaggagcat gaggtccgcc
    12181 aggccggcgc gcagcggtgc gaacggctcg gccacctcgt aggggacgta ctccacggcg
    12241 gacggcggga cgcccgcggc ggcggcgatc cgctccgcct ggcggggcgg gccgtgcacg
    12301 ccgaggcgga ccgggcgcgg cgcggcgggt gagggagccg cgccggttc
//
