LOCUS       NZ_CP030862            20741 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces globosus strain LZH-48 chromosome, complete genome.
ACCESSION   NZ_CP030862
VERSION     NZ_CP030862.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces globosus
  ORGANISM  Streptomyces globosus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Draft genome Sequence of streptomyces globosus LZH-48
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6863360)
  AUTHORS   Ran,K., Li,Z., Wei,S. and Dong,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JAN-2018) Institute of Biophysics, Dezhou University,
            566 DaXuexi RD, Dezhou, Shandong 253023, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SMRT Portal v. version 2.2.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 110.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003325375.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 02:22:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,671
            CDSs (total)                      :: 6,576
            Genes (coding)                    :: 6,458
            CDSs (with protein)               :: 6,458
            Genes (RNA)                       :: 95
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 41 of 118
            Pseudo Genes (incomplete)         :: 101 of 118
            Pseudo Genes (internal stop)      :: 11 of 118
            Pseudo Genes (multiple problems)  :: 32 of 118
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:39:31
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1277770
            Orig. end                         :: 1298511
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP030862.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20741
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="2"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20741
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20741
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10741](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10741)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     misc_feature    458..472
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            1139..3343
                     /locus_tag="C0216_RS06070"
                     /old_locus_tag="C0216_06065"
     CDS             1139..3343
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04215.1"
                     /locus_tag="C0216_RS06070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06065"
                     /product="choice-of-anchor A family protein"
                     /protein_id="WP_162793126.1"
                     /transl_table=11
                     /translation="MSARNWALGLAIGAVVAAGTPAAALAADTSGERPAAAAARAPLPG
                     GLGPCVPGDCPSPFPPIGSNGIPVGRDNAVNIFAGGDFRVRGTASEAEGRLVVLGGFDQ
                     DKQAGGDQRYNVGVVGAGSLVPPPAGADFLTTGRDVTVADGERLLADTGVVRYGGTLTG
                     TVTGTLVADPDAAAPYAGLRDRLTAASQCYARVDGQPRPATGTVVNSGFETLLTGDGTS
                     ALQVFNVDADLVNAGAMNGQQGIRFDRIPANATILVNVLGTTRTINTFSGGIADTDPLN
                     AYRERLLWNFPDATTVNLNGTGQFQGSVLIGNQASEATVTLPGMNGRFFTTGSVTHGSS
                     TLPGSGQEFHAYPFTGDLPECGPGPEPVTGAVSVLKRDENGAALPGARFELWRETNGQD
                     GAQFTGPDPDTRVAECTTGADGRCSREVEPGTYYWRETAAPDGYELPADPVFPLTLTAD
                     DAEAGVSVTVDNTRQPQPVTGRVAVRKVDAAGGAPLAGAVFELWRETNGTEGLQTLGIN
                     PDQRVGAECTTGADGRCSSEVEPGTYYWRETAAPDGYELPARPVATVVLTVQNASAGVT
                     VTLPNARRSDGGGAVQVLKRDKTTQLPLRGAAFDLWKEANGTEGLQTAGADPDLRIGSG
                     CTTDTAGRCGFRQLEPGSYYLVETAVPPGYVLPRNPVTGPLVLDANTPGATVAVTVDNR
                     REGACECKDKEHGKDKKDKKDKGKGKKKDKEKEKAEKPHS"
     misc_feature    complement(3417..3432)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            3530..4753
                     /locus_tag="C0216_RS06075"
                     /old_locus_tag="C0216_06070"
     CDS             3530..4753
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743355.1"
                     /locus_tag="C0216_RS06075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06070"
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_246042781.1"
                     /transl_table=11
                     /translation="MQPIRGRARRTGLPALLLGAALLFTSACSNGGDAGGAGAGSAGAG
                     GAAKTGTEASKAVVTVKPDDGSKEVATSGVLKITATGGKLTTVSVADTKGNQVEGKISA
                     DGAGWEPVRHLASATEYKVHAVAKDEAGRESAKDATFTTLTPKNTFIGHYTPEDGQTVG
                     VGMPVSFNFTRGITNTEAVEKAITVTAEPSVPIEGHWFGNDRLDFRPEKYWAAGTKVTV
                     KIALDGVEGRPGVYGKQTRTVSFTIGRSQVSTVDASEHTMQVVRDGQVIKNLPITAGAP
                     STTTYNGQMVISEKYKVTRMNGATVGFGGEYDISDVPHAMRLSTSGTFVHGNYWASAST
                     FGSQNVSHGCIGLKDVRGAYDGNQPAAWFFNESLIGDVVIVKNSKDKQIAPDNGLNGWN
                     MDWAEWVK"
     gene            4841..5608
                     /locus_tag="C0216_RS06080"
                     /old_locus_tag="C0216_06075"
     CDS             4841..5608
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (5-246). E-value: 1.1e-73. Score:
                     239.5. Matches aSDomain:
                     nrpspksdomains_C0216_RS06080_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432556.1"
                     /locus_tag="C0216_RS06080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06075"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_114054263.1"
                     /transl_table=11
                     /translation="MTLSLEVSEGVGTIRLDRPPMNALDIAAQDRLRELAAEAGDRADV
                     RAVILYGGEKVFAAGADIKEMQTMDHAAMVARSRALQDAFTAVARIPKPVVAAVTGYAL
                     GGGCELALCADYRIAADNAKLGQPEILLGLIPGAGGTQRLSRLVGPSKAKDLIFTGRMV
                     KADEALALGLVDRVVPAAEVYGQAQAWAAALAKGPAIALRAAKECVDAGLEADIDTGLA
                     IERNWFAGLFATEDRERGMRSFVEEGPGKAKFL"
     aSDomain        4856..5578
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C0216_RS06080_ECH.1"
                     /evalue="1.10E-73"
                     /label="C0216_RS06080_ECH.1"
                     /locus_tag="C0216_RS06080"
                     /protein_end="246"
                     /protein_start="5"
                     /score="239.5"
                     /tool="antismash"
                     /translation="EVSEGVGTIRLDRPPMNALDIAAQDRLRELAAEAGDRADVRAVIL
                     YGGEKVFAAGADIKEMQTMDHAAMVARSRALQDAFTAVARIPKPVVAAVTGYALGGGCE
                     LALCADYRIAADNAKLGQPEILLGLIPGAGGTQRLSRLVGPSKAKDLIFTGRMVKADEA
                     LALGLVDRVVPAAEVYGQAQAWAAALAKGPAIALRAAKECVDAGLEADIDTGLAIERNW
                     FAGLFATEDRERGMRSFVE"
     gene            5787..6359
                     /locus_tag="C0216_RS06085"
                     /old_locus_tag="C0216_06080"
     CDS             5787..6359
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266679.1"
                     /locus_tag="C0216_RS06085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06080"
                     /product="ATP-binding protein"
                     /protein_id="WP_246042782.1"
                     /transl_table=11
                     /translation="MTLRGVFSRGTARAGPQPVHDGCMAGLEGVEQPRPQGGAAAVRPT
                     AALEDEQGLGAVEEYGNPAEAEVTLPSMPVSAGTARRLAQYVVIRFWGFSPQVAEHTVL
                     LVSELVGNAVRHTGARSFGLRMVRRRGWIRVEVRDPSRGLPCLMPVQELDTTGRGLFLV
                     DKLSDRWGADLLPRGKITWFEMRVADR"
     misc_feature    6156..6158
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6745..7536
                     /locus_tag="C0216_RS06090"
                     /old_locus_tag="C0216_06085"
     CDS             6745..7536
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955798.1"
                     /locus_tag="C0216_RS06090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06085"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_246042341.1"
                     /transl_table=11
                     /translation="MPCYPDRRSALRAGAAAAAGVLATACGAGGAHPSAAPASAAPAKA
                     APARPPRRPAAAPRRFAGQPEEIAHGPRTRPEVALTFHGNGDPATARAVLAEAERAGAR
                     VTVLAVGTWLDAHPAMAARILDGGHELGNHTQRHLALNDLPEAEAYAEITGCAQRLRRL
                     TGSIGTWFRPSQTQHATPLVRTLARRAGYPHVLSYDVDSLDFTSPGAAAVIRTVTGTIR
                     SGSVVSLHFGYADTVDAMPPLLEELARRKLRAVTTTELLTP"
     gene            7533..8723
                     /locus_tag="C0216_RS06095"
                     /old_locus_tag="C0216_06090"
     CDS             7533..8723
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743359.1"
                     /locus_tag="C0216_RS06095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06090"
                     /product="YncE family protein"
                     /protein_id="WP_114054266.1"
                     /transl_table=11
                     /translation="MTTPRPSRKAAALVAGLALAALAGCGSADRGPAEALGSKAPAGRP
                     AKAVPAAPPGLPGMPPLLDPNDVYAADRPNALSPVVKDFPSRVYVPNTNSNTVSVIDPA
                     TYKVIDTIPVGVQPQHVVPSWDLKTLWVNNNRGHTLTPINPATGEAGKPVEVHDPYNLY
                     FTPNGKYAVVMASMDKELVFRDPHTMDRVKTVPVTCFGVNHADFSADGRYFIVSCEFSG
                     ELLKVDTEKMEVVAQQKLPFEGAMPQDVKVSPDGKTFYVADMMAHGMWVLSGDRFETPK
                     LLPTGKGCHGLYVSRDSREMYVSNRGEGSVSVFDFKQNKITKKWELPDGGSPDMGGVSA
                     DGKVLWLSGRYDNEVYAIDTVTGKELARVPVGGGPHGLAVYPQPGRYSLGHTGIFR"
     gene            complement(8782..10020)
                     /locus_tag="C0216_RS06100"
                     /old_locus_tag="C0216_06095"
     CDS             complement(8782..10020)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889608.1"
                     /locus_tag="C0216_RS06100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06095"
                     /product="cytochrome P450"
                     /protein_id="WP_114054267.1"
                     /sec_met_domain="p450 (E-value: 4e-12, bitscore: 44.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGGQPDTGRQQAAPLLDFPLSRRGDALPEECARLRGKAPVARVR
                     TLTGDEAWLVSSYALARQVLEDDRFSLRDTANDGVPRQYALTIPPEVVDNMGTITSAGL
                     RAAVMKSLNPRQAGLQEALRATAHALLDAMAAEGAPADLRAAFADPYSAAMHCRILGVP
                     SDDWRRLMSGLDVAFMTAREPFADSALNWYKDVGYFADRLAGQAALPAEERTGLLGRFA
                     ELKESDPESAHLTDEMFATVAVSLFGAGAVSTSAFLVLAVLALLQRPELIGWLRRHPER
                     MGVAVDELLRWNLSVGDGLPRIALADVRVGDVLVREGELVLVLLEGANFDPAAFDRPEE
                     LDLERESRNAHLAFGAGRHFCPASALGRVHAMIALEVLVERLPGLRLAVPAENLVWRTG
                     FIKRLPERLPVAW"
     gene            complement(10001..10741)
                     /locus_tag="C0216_RS06105"
                     /old_locus_tag="C0216_06100"
     CDS             complement(10001..10741)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889609.1"
                     /locus_tag="C0216_RS06105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06100"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_246042342.1"
                     /sec_met_domain="CDPS (E-value: 1.4e-80, bitscore: 268.5,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAITADASFEVLPFTRACRHIWEDGDHVLIGVSPGNSYFGSDRIG
                     SLARWASSRFAQVDFVYADLHVDRMFAAFGYSREHAARRASKEIKAVRRRVLKGVEESV
                     RAHPGIRVSALSDFQSNSVYRLLHRRVLHFLETDGEFRKGCEEMAVHFVGPKLPEGESM
                     TDAQLQACFDYLAAELPFFLDTPSILDVPSSVAAYHVRMPLTDLLFARGGGLRATRNQG
                     CAVVRPEPADRAPAEGSADERRAA"
     misc_feature    complement(10734..10748)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
     gene            10997..11209
                     /locus_tag="C0216_RS06110"
                     /old_locus_tag="C0216_06105"
     CDS             10997..11209
                     /GO_function="GO:0005509 - calcium ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266682.1"
                     /locus_tag="C0216_RS06110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06105"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_114054268.1"
                     /transl_table=11
                     /translation="MADIESARATFGRFDADGDGFVTADEFRQAMAQMGDPFVTGPVAD
                     AVIAARDTDADGLMSFDEFWASLNK"
     gene            complement(11273..11866)
                     /locus_tag="C0216_RS06115"
                     /old_locus_tag="C0216_06110"
     CDS             complement(11273..11866)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972077.1"
                     /locus_tag="C0216_RS06115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06110"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_114054269.1"
                     /transl_table=11
                     /translation="MSLPHAILTALLEKPSSGLELTRRFDRSIGYFWSATHQQIYRELG
                     RLEEAGYIRALPGDGPVRGQRKAYEVLPAGSGELARWVGGSQDPKAIRDPLLLRVRAAA
                     VVGTDGLLAELRRHLELHRRQLALYEAIEERDFPPGRDSDEDRLRRLVLHGGIGLETFW
                     LRWLEEALEEVGGMADLPGGDPDAAGPADGAGAP"
     gene            complement(11939..12760)
                     /locus_tag="C0216_RS06120"
                     /old_locus_tag="C0216_06115"
     CDS             complement(11939..12760)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743362.1"
                     /locus_tag="C0216_RS06120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06115"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_114054270.1"
                     /transl_table=11
                     /translation="MNPLVELAGAGYAYEDGPAVLDGVDFSIAESRALVLLGRNGSGKT
                     TLMRLLSGGLRPASGELLLDGTPVAYDRAGLTRLRKAVQLVVQDPDDQLFAASVEQDVS
                     FGPMNLGLSAAEVRARVGEALSALGITALRDRPTHLLSYGQRKRAAIAGAVAMAPRVLI
                     LDEPTAGLDPEGQERLLDALAGLRAAGTTVVMATHDVDLAVRWADDAAVLTPDGIRFGP
                     AAALLSDPELLAGAGLRQAWAPAVAAFLRSGGRLAADALGPKTPEALASWH"
     gene            complement(12757..13506)
                     /gene="cbiQ"
                     /locus_tag="C0216_RS06125"
                     /old_locus_tag="C0216_06120"
     CDS             complement(12757..13506)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0032778 - P-type cobalt transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006824 - cobalt ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cbiQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030565.1"
                     /locus_tag="C0216_RS06125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06120"
                     /product="cobalt ECF transporter T component CbiQ"
                     /protein_id="WP_114054271.1"
                     /transl_table=11
                     /translation="MLPIDVAAHGSRWRGRHPLEKALLGLGLTVTAVCLPPWPGGPLVA
                     AATLAVLLGPAGVAGRQLWRAFRIPLGFCFTGALPLLFAVGGAAGPVSLAPDGPRHAGE
                     LLLRTSAASLGVLLFAFTTPVSDVLPRLVRAGVPAPVVDVALVMYRIGFLLLDSLAQVR
                     RAQAARLGHADRAAVWRSLAGLAATSFVRAFDRAARLQSGLAGRGYDGALRVLVPEAAL
                     SRRFLAASAALIAGLVALTYTLEGLYS"
     gene            complement(13510..13860)
                     /locus_tag="C0216_RS06130"
                     /old_locus_tag="C0216_06125"
     CDS             complement(13510..13860)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015087 - cobalt ion transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006824 - cobalt ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445148.1"
                     /locus_tag="C0216_RS06130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06125"
                     /product="energy-coupling factor ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_114058484.1"
                     /transl_table=11
                     /translation="MSRNAKINTLLLLVVAALAVLPLALGLGEGREEPFAGADAQAEAA
                     ITELRPDYEPWFTPLYEPPSGEVESALFALQAALGAGVLAYYFGVRRGRRQGAAAAAAI
                     GSGTPGDTRAEG"
     gene            complement(13866..14558)
                     /locus_tag="C0216_RS06135"
                     /old_locus_tag="C0216_06130"
     CDS             complement(13866..14558)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_process="GO:0000041 - transition metal ion transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005474518.1"
                     /locus_tag="C0216_RS06135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06130"
                     /product="energy-coupling factor ABC transporter permease"
                     /protein_id="WP_114054272.1"
                     /transl_table=11
                     /translation="MHIAEGFLPPLHAAAWGAASAPFVVHGVRALTREVKENPESTLLL
                     GASGAFTFVLSALKIPSVTGSCSHPTGTGLGAILFRPPIMAVLGTITLLFQALLLAHGG
                     LTTLGANVFSMAIAGPWAGFGVYLLLRRSGAPLMVSVFFGAFTADLVTYCVTSVQLALA
                     FPDPGSGVAGALAKFGGIFAVTQIPLAVSEGLLTVLVMRLLMQSSKSDLVRLGVAKLAG
                     RSDRKAAA"
     regulatory      complement(14587..14782)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            15079..15810
                     /locus_tag="C0216_RS06140"
                     /old_locus_tag="C0216_06135"
     CDS             15079..15810
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014059112.1"
                     /locus_tag="C0216_RS06140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06135"
                     /product="flavodoxin family protein"
                     /protein_id="WP_114054273.1"
                     /transl_table=11
                     /translation="MAAEPDTANPYDYSDLTALFVNCTLKRSPETSNTEGLIDRSRAVM
                     ESAGARTSVVRAVDHDIATGVWPDMTEHGWETDQWPVLYSRVMDADILVLCGPIWLGDN
                     SSVMKQVIERLYACSSLLNEHGQYAYYGRVGGALVTGNEDGVKHCAMNILYSLQHLGYA
                     IPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRNTAFMSWNLMHLAALLKRSGGIPAH
                     GNQRSLWDAGCRFDFPNPEHR"
     gene            complement(15833..16354)
                     /locus_tag="C0216_RS06145"
                     /old_locus_tag="C0216_06140"
     CDS             complement(15833..16354)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136948.1"
                     /locus_tag="C0216_RS06145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06140"
                     /product="hypothetical protein"
                     /protein_id="WP_114054274.1"
                     /transl_table=11
                     /translation="MNHLRRRRTAALATGVLLTAALALAAPASTAAAPSGRAPATPLVV
                     GARWAGHCAYDRIVIDLKGYVPDADVTRVPALHQDGSGAPVPLAGKHFLQIRLHPAAAH
                     LRSGEGTYRGPKLVRTNLPALKGLAMTGDFEGYVTFGAAFDSRPSYKAFTLRSPDRFVV
                     DIAHRNVCCG"
     misc_feature    complement(16418..16434)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.22"
                     /tool="antismash"
     misc_feature    complement(16430..16442)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     misc_feature    16438..16454
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.57"
                     /tool="antismash"
     gene            complement(16519..17901)
                     /locus_tag="C0216_RS06150"
                     /old_locus_tag="C0216_06145"
     CDS             complement(16519..17901)
                     /EC_number="4.3.1.17"
                     /GO_function="GO:0003941 - L-serine ammonia-lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0009063 - amino acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889625.1"
                     /locus_tag="C0216_RS06150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06145"
                     /product="L-serine ammonia-lyase"
                     /protein_id="WP_114058485.1"
                     /transl_table=11
                     /translation="MAISVFDLFSIGIGPSSSHTVGPMRAARMFVNRLKKDGLLAQTAS
                     VRAELYGSLGATGHGHGTPKAVLLGLEGHSPRTVDVETADDEVERIRSTGRLRLLGTEI
                     GSAHEIAFDEPNQLVLHRRRSLPYHANGMTLFAYDAAGTPLLEKTYYSVGGGFVVDEDA
                     VGEDRIKLDDTVLKYPFRSGDEMLRLAKETGLSISSLMLENEKAWRTEEEIREGLLEIW
                     RVMQACVSRGMSREGILPGGLRVKRRAAATARQLRTEGDPMMHRSEWTTIYAMAVNEEN
                     AAGGRVVTAPTNGAAGVLPAVLHYYVNFVPGADEDGVVRFLLAAGAIGMLFKENASISG
                     AEVGCQGEVGSACSMAAGALAEVLGGTPEQVENAAEIGMEHNLGLTCDPVGGLVQIPCI
                     ERNGMAAVKAVTAAKMAMRGDGSHKVSLDKVIKTMKETGADMKIKYKETARGGLAVNVI
                     EC"
     misc_feature    17999..18015
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.18"
                     /tool="antismash"
     misc_feature    complement(18038..18054)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.58"
                     /tool="antismash"
     gene            complement(18193..19449)
                     /gene="glyA"
                     /locus_tag="C0216_RS06155"
                     /old_locus_tag="C0216_06150"
     CDS             complement(18193..19449)
                     /EC_number="2.1.2.1"
                     /GO_function="GO:0004372 - glycine hydroxymethyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0070905 - serine binding [Evidence IEA]"
                     /GO_process="GO:0019264 - glycine biosynthetic process from
                     serine [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (76-366). E-value:
                     1.3e-12. Score: 39.5. Matches aSDomain:
                     nrpspksdomains_C0216_RS06155_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="glyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266694.1"
                     /locus_tag="C0216_RS06155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06150"
                     /product="serine hydroxymethyltransferase"
                     /protein_id="WP_114054275.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.5e-10, bitscore:
                     39.2, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVLNTPLHELDPDVAAAVDAELARQQSTLEMIASENFAPVAVME
                     AQGSVLTNKYAEGYPGRRYYGGCEHVDVVEQIAIDRIKALFGAEAANVQPHSGAQANAA
                     AMFALLKPGDTIMGLNLAHGGHLTHGMKINFSGKLYNVVPYHVGEDGQVDMAEVERLAK
                     ESKPQLIVAGWSAYPRQLDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHV
                     VTTTTHKTLGGPRGGVILSTQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKVAASPEF
                     KERQERTLAGAKIIAERLVQDDVKAVGVDVLSGGTDVHLVLVDLRNSELDGQQAEDRLH
                     EIGITVNRNAIPNDPRPPMVTSGLRIGTPALATRGFGAEDFTEVADVIAEALKPSYDGE
                     ALKARVSALAAKHPLYPSL"
     aSDomain        complement(18352..19221)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C0216_RS06155_Aminotran_1_2.1"
                     /evalue="1.30E-12"
                     /label="C0216_RS06155_Aminotran_1_2.1"
                     /locus_tag="C0216_RS06155"
                     /protein_end="366"
                     /protein_start="76"
                     /score="39.5"
                     /tool="antismash"
                     /translation="IAIDRIKALFGAEAANVQPHSGAQANAAAMFALLKPGDTIMGLNL
                     AHGGHLTHGMKINFSGKLYNVVPYHVGEDGQVDMAEVERLAKESKPQLIVAGWSAYPRQ
                     LDFAAFRRIADEVGAYLMVDMAHFAGLVAAGLHPNPVPHAHVVTTTTHKTLGGPRGGVI
                     LSTQELAKKINSAVFPGQQGGPLEHVIAAKAVSFKVAASPEFKERQERTLAGAKIIAER
                     LVQDDVKAVGVDVLSGGTDVHLVLVDLRNSELDGQQAEDRLHEIGITVNRNAIPNDPRP
                     PMVTSGLRI"
     gene            complement(19464..19847)
                     /gene="gcvH"
                     /locus_tag="C0216_RS06160"
                     /old_locus_tag="C0216_06155"
     CDS             complement(19464..19847)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0019464 - glycine decarboxylation via
                     glycine cleavage system [Evidence IEA]"
                     /codon_start=1
                     /gene="gcvH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008743370.1"
                     /locus_tag="C0216_RS06160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C0216_06155"
                     /product="glycine cleavage system protein GcvH"
                     /protein_id="WP_114054276.1"
                     /transl_table=11
                     /translation="MSNPQQLRYSKEHEWLSAAEDGVATVGITAFAANALGDVVYAQLP
                     AVGDTVTAGETCGELESTKSVSDLYSPVTGEVVEANQDVVDDPSLVNSAPFEGGWLFKV
                     RVSEEPEDLLSAAEYEQLTLSGN"
ORIGIN
        1 tggaggacgc ccaggaggtg cgggtccccg gcacgatcgc ccccgacggg ctcagctgga
       61 gccccgaccc ggacgccggc cgcctcgcgc tcgccgccaa gtacaccgtg gacgccgtcg
      121 ccgtcgacgg ccacaaccgc cgccaggccc gccacaccac cttcaccacg tacgtgcccg
      181 aggagcgctt catcggctac ttcaagccgg agaaccgctc caccgtcggc gtcggcatga
      241 tcgtgtcctt ccggttcagc aggcccatcg agaaccgggc cgacgtcgag cgggccgtca
      301 ccgtcaccgc cgatccgccc gtcgaggtcg ccggccactg gttcggccgc gaccgcctcg
      361 acttccggcc ccgggagtac tggaagccgg gcaccgaggt cacggtccgc atccggctgc
      421 gcgacgtcca gggcgccccc ggctcgtacg gcatccagga caagacggtc cgcttcaccg
      481 tcggccgcgc gcaggtctcc acggtggacg cggccgcgca caccatggcg gtccgccgcg
      541 acggccggct gctgtcgacg gtccccatca gcgccgggtc cccggagaac ccgacctaca
      601 acggcaggat ggtggtgatg gagatgtacg acgtcacccg gatgaacggg cagaccgtgg
      661 gcttcggcgg cgagtacgac atccccgacg tcccgcacgc gatgcggctc accacctccg
      721 gcaccttcct gcacggcaac tactgggtca gccccgacac cttcggctcc gccaacacca
      781 gccacggctg cgtgggcctg cgcgacgaca agggcggcgg ctccgacacc cccgcgggct
      841 ggttcttcga ccggaccctc gtcggcgacg tggtggaggt cgtgaactcg caggacaaga
      901 cggtcgcccc ggacaacggg ctgggcggct ggaacatgcc ctggacggag tgggccgcag
      961 gctccgccct gtcctgaccg ctgtcctccg ccggccgccc ggcccgcgct cccgccctgc
     1021 gggcgctcgg gtgaacgcat gaccggtttg ccgtagcgca gggagtgtcc gcgcgccccc
     1081 cgccgcgccc cgcccgcagc ctgacagggc acatcagcgc aggcaaggac ggagtctcat
     1141 gtcagcaagg aactgggccc tcgggctcgc gatcggagcc gtcgtggccg cggggacacc
     1201 cgccgcggcc ctggccgccg acaccagcgg ggaacggccc gccgcggccg cggcgcgggc
     1261 cccgctgccc ggcggcctcg gcccgtgcgt ccccggcgac tgccccagcc ccttcccgcc
     1321 gatcggcagc aacggcatcc cggtgggccg cgacaacgcc gtcaacatct tcgcgggcgg
     1381 ggacttccgc gtccgcggca ccgcctccga ggccgagggc cgcctcgtcg tcctgggcgg
     1441 tttcgaccag gacaagcagg cgggcgggga ccagcggtac aacgtgggcg tcgtcggcgc
     1501 cggctcgctg gtgccgccgc cggcgggggc ggacttcctc accaccggcc gggacgtcac
     1561 cgtcgcggac ggcgagcgac tcctcgccga caccggggtg gtccgctacg gcggcaccct
     1621 caccggcacc gtgaccggca ccctcgtcgc cgaccccgac gccgccgccc cctacgccgg
     1681 cctgcgcgac cggctcaccg ccgccagcca gtgctacgcc cgggtcgacg gacagccccg
     1741 cccggccacc ggcacggtcg tcaacagcgg cttcgagacc ctcctcaccg gggacggcac
     1801 ctcggccctc caggtgttca acgtcgacgc cgacctggtc aacgccggcg ccatgaacgg
     1861 ccagcagggc atccgcttcg accggatccc cgcgaacgcc accatcctcg tcaacgtcct
     1921 cggcaccacc cgcaccatca acaccttcag cggcgggatc gcggacaccg accccctcaa
     1981 cgcctaccgc gaacggctcc tgtggaactt cccggacgcc acgacggtca acctgaacgg
     2041 caccggccag ttccagggca gcgtcctgat cggcaaccag gcgtccgagg ccacggtcac
     2101 cctccccggc atgaacggcc gcttcttcac caccggctcc gtcacccacg gcagctccac
     2161 cctcccgggc agcggccagg agttccacgc ctaccccttc accggcgacc tccccgaatg
     2221 cggccccggc cccgagccgg tcaccggcgc ggtgtccgtg ctcaagcggg acgagaacgg
     2281 ggccgcgctg cccggggccc gcttcgagct gtggcgggag acgaacggac aggacggggc
     2341 ccagttcacc ggtcccgacc cggacacccg cgtcgcggag tgcaccaccg gcgcggacgg
     2401 ccgctgctcg cgcgaggtcg aacccggcac ctactactgg cgggagacgg ccgcccccga
     2461 cggctacgaa ctccccgccg accccgtctt cccgctgacc ctgaccgccg atgacgccga
     2521 ggcgggcgtc agcgtcaccg tcgacaacac gaggcagccc cagccggtca cggggcgggt
     2581 cgccgtccgc aaggtcgacg ccgcgggcgg agccccgctg gccggagccg tcttcgagct
     2641 ctggcgcgag accaacggga cggaggggct gcagaccctc ggcatcaacc ccgaccagcg
     2701 tgtcggcgcg gagtgcacca ccggcgcgga cggccgctgc tccagcgagg tcgaacccgg
     2761 cacctactac tggcgggaga ccgccgctcc cgacgggtac gagctgcccg cccggcccgt
     2821 cgcgaccgtc gtgctgacgg tgcagaacgc gtcggccggg gtgacggtga cgctccccaa
     2881 cgcccggcgc agcgacggcg gaggcgccgt ccaggtcctg aagcgggaca agacgacgca
     2941 gctcccgctg cgcggggcgg cgttcgacct ctggaaggag gccaacggca ccgaggggct
     3001 ccagaccgca ggcgcggacc ccgacctccg catcgggtcg ggctgcacca cggacaccgc
     3061 gggccgctgc gggttccggc agctggagcc gggctcgtac tacctggtgg agactgccgt
     3121 gcccccgggc tacgtgctcc cgcgcaaccc cgtcaccggc ccgctcgtcc tggacgcgaa
     3181 caccccgggc gccacggtcg cggtgacggt cgacaaccgc cgcgagggcg cgtgcgagtg
     3241 caaggacaag gagcacggca aggacaagaa ggacaagaag gacaagggca agggcaagaa
     3301 gaaggacaag gagaaggaga aggccgagaa gccgcactcc tgatccgttg ttccccgagt
     3361 gcccccgcgc ggtcccgagc cgcgcggggg cactccgctg cccgctgccg ggtcttggga
     3421 cggaacggtg acatgaccgt ttctcttcgt gatgtctcgg tgtgttttcc tgtgggcaag
     3481 cgcgcgagcg tccgcgcgcg ggggacgtgg ggagaagaga aaagtgaagc tgcagccgat
     3541 tcgcggccgt gcccgccgca ccggtctgcc ggcccttctg ctgggagcgg cgctgctgtt
     3601 cacgagcgcg tgcagcaacg gcggcgacgc cggcggcgca ggcgccggca gcgcaggcgc
     3661 ggggggcgcg gccaagacgg ggacggaggc ctccaaggcg gtcgtcaccg tcaagccgga
     3721 cgacgggtcc aaggaagtgg ccaccagcgg cgtcctgaag ataaccgcaa ccggcggcaa
     3781 gctcaccacg gtgagcgtcg ccgacaccaa gggcaaccag gtcgagggca agatatcggc
     3841 ggacggcgcc ggctgggagc cggtgcggca cctggcctcg gccaccgagt acaaggtgca
     3901 cgcggtcgcc aaggacgagg cgggccgcga gtccgccaag gacgccacct tcaccaccct
     3961 caccccgaag aacaccttca tcggccacta cacgcccgag gacgggcaga ccgtcggcgt
     4021 cggcatgccg gtgtcgttca acttcacccg cggcatcacc aacaccgagg cggtcgagaa
     4081 ggccatcacg gtgacggccg agccgtccgt cccgatcgag ggccactggt tcggcaacga
     4141 ccgcctcgac ttccgcccgg agaagtactg ggccgccgga accaaggtca ccgtgaagat
     4201 cgccctggac ggggtcgagg gccggccggg cgtctacggc aagcagaccc gcacggtcag
     4261 cttcacgatc ggccgctcgc aggtctccac ggtcgacgcg agcgagcaca cgatgcaggt
     4321 cgtccgcgac ggccaggtca tcaagaacct gcccatcacc gcaggcgccc cgtcgacgac
     4381 cacgtacaac ggccagatgg tcatcagcga gaagtacaag gtgacccgga tgaacggcgc
     4441 gaccgtcggg ttcggcggcg agtacgacat ctccgacgtc ccgcacgcga tgcggctgtc
     4501 gacctcgggc accttcgtcc acggcaacta ctgggcctcg gcgagcacgt tcggatcgca
     4561 gaacgtcagc cacggctgca tcggcctgaa ggacgtccgc ggcgcctacg acggcaacca
     4621 gcccgccgcc tggttcttca acgagtcgct catcggcgac gtcgtcatcg tgaagaactc
     4681 caaggacaag cagatcgccc cggacaacgg cctcaacggc tggaacatgg actgggcgga
     4741 gtgggtcaag taacccctcc gcgagcccgc tgacggcggc ccggtgctgt gacccacggc
     4801 accgggccgt ttggtgttaa ccggcgctaa ccttccccgt atgaccctct ctctcgaagt
     4861 ctccgaaggc gtcggcacca tccgcctgga ccggccgccc atgaacgccc tggacatcgc
     4921 cgcccaggac cggctgcgcg agctggcggc cgaggccggc gaccgcgccg acgtccgggc
     4981 cgtcatcctc tacggcggcg agaaggtgtt cgcggccggc gcggacatca aggagatgca
     5041 gacgatggac catgcggcga tggtcgcccg gtcccgcgcg ctccaggacg ccttcaccgc
     5101 cgtggcgcgg atccccaagc cggtcgtggc ggccgtcacc ggctacgcgc tgggcggcgg
     5161 ctgcgagttg gcgctctgcg cggactaccg catcgccgcc gacaacgcca agctcggcca
     5221 gcccgagatc ctgctcggcc tcatccccgg cgcgggcggc acccagcgcc tctcccgcct
     5281 ggtcggcccg tccaaggcca aggacctgat cttcaccggc cggatggtca aggcggacga
     5341 ggcgctcgcc ctcggcctcg tcgaccgggt ggtgcccgcg gcggaggtgt acgggcaggc
     5401 gcaggcctgg gccgcggcgc tcgccaaggg cccggccatc gcgctccgtg cggcgaagga
     5461 gtgcgtcgac gcgggcctgg aggcggacat cgacacgggc ctggccatcg aacggaactg
     5521 gttcgcgggc ctgttcgcga ccgaggaccg ggagcggggc atgcgcagct tcgtcgagga
     5581 ggggccgggc aaggcgaagt tcctctaggg cggcgggaat tcgccggtcc tccctggggg
     5641 tggattagcc cggccttaac gcggccttaa gcggggcggg cgaccgcccg cgggtgatca
     5701 tcgcagtgcg gtgcgtcatc gcagttcagc gccgccgggc gggcctccgg ttgcccggcg
     5761 catatgacgg ggcacccctg cgcggcatca cgctgcgggg ggtgttttcc cgcggaacgg
     5821 cccgggcggg cccgcagccc gtccatgatg ggtgcatggc gggcctggag ggtgtggagc
     5881 agccgcggcc gcagggcggc gccgcggccg tgcggccgac ggcggcactg gaggacgagc
     5941 agggcctcgg cgcggtggag gagtacggca atccggccga ggcggaggtg accctgccgt
     6001 ccatgccggt ctcggcgggc accgcccgcc ggctcgccca gtacgtggtg atccgcttct
     6061 ggggcttctc cccgcaggtc gccgagcaca ccgtgctgct ggtgtccgaa ctcgtcggca
     6121 acgcggtgcg ccatacgggc gcccgctcgt tcggcttacg gatggtgcgg cggcgcggct
     6181 ggatccgggt ggaggtgcgc gacccctcgc gggggctgcc ctgcctgatg ccggtgcagg
     6241 agctggacac cacggggcgg gggctcttcc tcgtcgacaa gctgtccgac cggtggggcg
     6301 cggacctgct gccccgcggc aagatcacct ggttcgagat gcgggtggcg gaccgctgag
     6361 cgggccccgg aacgcctgaa gcccccgtgc gccgcggtgg ggcgtcgtgg gggcttcatg
     6421 ggtgcgccga ggatcgaaag gggtgtgatc ctcggcgtgg gcgacttcgc tcgggtcaat
     6481 gggaagccgt gattccgact atggcagacg ggggaccgaa tgccaaaagt cccaacttgg
     6541 acataagtgt gcatatccca agactttccc gctaaatctt aggtgaggtc cgccacgcac
     6601 ctcgtaatcc atgaataaat atccaccccc ctgtgtgaat ccttgatcag gcggcgggtt
     6661 aacccccgaa tggcccctct ttggttggtg tcccgaattg ggtcaatcgt tacttctcgg
     6721 cacaacgccc ccttaaatgg gcgggtgcct tgctacccgg accgcaggtc cgccctccgc
     6781 gccggtgcgg cggccgccgc cggagtcctc gccaccgcct gtggcgcggg cggcgcccac
     6841 ccctccgccg caccggcctc cgcggccccc gccaaggccg ccccggcccg gccgccccgc
     6901 cgccccgcgg ccgcgccgcg ccgcttcgcc gggcagcccg aggagatcgc gcacggtccc
     6961 cgcacccgcc ccgaggtggc cctcaccttc cacggcaacg gcgaccccgc gaccgcccgc
     7021 gccgtcctcg ccgaggccga gcgcgccggc gcccgggtca ccgtcctcgc cgtcggcacc
     7081 tggctcgacg cccaccccgc aatggccgcg cgcatcctgg acggcggcca cgaactcggc
     7141 aaccacaccc agcgccacct cgccctcaac gacctgccgg aggccgaggc ctacgccgag
     7201 atcaccggct gcgcccagcg cctgcggcgg ctcaccggct ccatcggcac ctggttccgc
     7261 ccctcgcaga cgcagcacgc cacccccctc gtccggacgc tggcccgcag ggcgggctac
     7321 ccgcacgtcc tctcgtacga cgtggactcc ctcgacttca cctcgcccgg cgcggcggcc
     7381 gtcatccgca ccgtcaccgg gacgatccgc agcggatccg tggtgagcct gcacttcggc
     7441 tacgcggaca cggtcgacgc gatgccgccc ctcctcgaag aactcgcgcg ccggaagctg
     7501 cgcgcggtga ccaccacgga gctgctgacc ccatgacgac cccccgcccc tcccgtaagg
     7561 ccgccgcgct cgtggccggt ctggccctcg ccgccctggc cggctgcgga tcggccgacc
     7621 ggggccccgc cgaggcgctc ggctccaagg cccccgccgg ccggccggcc aaagccgtcc
     7681 ccgcggcccc gccgggcctc cccggcatgc cgccgctcct cgacccgaac gacgtctacg
     7741 ccgccgaccg gccgaacgcg ctgtccccgg tggtcaagga cttcccgtcg cgcgtctacg
     7801 tcccgaacac caactccaac accgtctcgg tcatcgaccc ggcgacgtac aaggtcatcg
     7861 acaccatccc ggtgggcgtc cagccgcagc acgtcgtccc ctcctgggac ctgaagaccc
     7921 tctgggtcaa caacaaccgc gggcacaccc tcaccccgat caacccggcg accggcgagg
     7981 ccggcaaacc ggtcgaggtg cacgacccgt acaacctgta cttcacgccg aacggcaagt
     8041 acgcggtcgt catggcctcc atggacaagg agctcgtctt ccgcgacccg cacaccatgg
     8101 accgggtcaa gacggtcccc gtgacctgct tcggcgtcaa ccacgccgac ttctcggcgg
     8161 acggccgcta cttcatcgtc tcctgcgagt tctccgggga gctgctgaag gtggacacgg
     8221 agaagatgga ggtcgtcgcc cagcagaagc tgcccttcga gggggccatg ccgcaggacg
     8281 tgaaggtgtc cccggacggc aagaccttct acgtcgccga catgatggcg cacggcatgt
     8341 gggtgctcag cggggaccgg ttcgagacgc cgaagctgct gcccaccggc aagggctgcc
     8401 acgggctgta cgtcagccgc gactccaggg agatgtacgt ctccaaccgc ggcgagggct
     8461 ccgtgtccgt cttcgacttc aagcagaaca agatcacgaa gaagtgggag ctgccggacg
     8521 gcggcagccc cgacatgggc ggcgtcagcg ccgacggcaa ggtgctgtgg ctgtccggcc
     8581 gctacgacaa cgaggtctac gcgatcgaca cggtgacggg caaggagctc gcccgggtcc
     8641 ccgtcggcgg cggcccgcac ggcctggccg tctaccccca gccgggccgc tactccctcg
     8701 gccacaccgg catcttccgc tgaggacgtg cggggaggcg ctccggtccg cggcccggtc
     8761 cgcagcgcct ccccgcgcgg atcaccaggc gaccgggagc cgctccggca ggcgcttgat
     8821 gaagccggtg cgccacacca ggttctccgc gggcacggcg agccgcagcc cgggcagccg
     8881 ctccaccagc acctccagcg cgatcatcgc gtgcacccgg cccagcgcgg aggccgggca
     8941 gaagtgccgg cccgcgccga acgcgaggtg ggcgttgcgg ctctcgcgct ccaggtccag
     9001 ctcctccggc cggtcgaagg ccgccgggtc gaagttggcc ccttcgagga ggacgaggac
     9061 gagctcgccc tccctgacga ggacgtcgcc gacccggacg tcggcgagcg cgatgcgcgg
     9121 caggccgtcg ccgacggaca ggttccagcg cagcagctcg tccacggcca cccccatccg
     9181 ctcgggatgt ctgcgcagcc atccgatgag ttccggccgc tggagcagcg ccagtacggc
     9241 gaggacgagg aacgcggacg tggacacggc gccggcgccg aagagggaca cggcgacggt
     9301 cgcgaacatc tcgtcggtga ggtgcgccga ctccgggtcg gactccttca gctccgcgaa
     9361 ccggccgagg agccccgtac gctcctcggc gggcagggcg gcctgccccg ccagccggtc
     9421 ggcgaagtag ccgacgtcct tgtaccagtt gagggcggag tcggcgaacg gctcgcgcgc
     9481 ggtcatgaac gcgacgtcca gcccggacat caggcgccgc cagtcgtcgg acggcacgcc
     9541 caggatccgg cagtgcatgg ccgccgagta ggggtcggcg aacgcggccc gcaggtcggc
     9601 gggcgccccc tcggcggcca tcgcgtcgag gagggcgtgg gccgtggccc gcagcgcttc
     9661 ctgaaggccc gcctggcgcg ggttcagcga cttcatcacc gcggcccgca ggcccgcgct
     9721 ggtgatggtg cccatgttgt cgacgacctc gggcgggatc gtcagcgcgt actgccgggg
     9781 gacgccgtcg ttcgccgtgt ccctcaggct gaaccggtcg tcctccagca cctgcctggc
     9841 cagcgcgtag ctgctcacca gccaggcctc gtcgcccgtc agggtgcgga ccctggcgac
     9901 aggcgccttc ccgcgcagcc gggcgcactc ctcggggagg gcgtcgccgc ggcgcgacag
     9961 cgggaagtcg aggagggggg cggcctgctg ccggcccgtg tcaggctgcc cgccgctcat
    10021 cggcgctccc ttcggccggt gcgcggtccg cgggctccgg ccggacgacg gcgcagccct
    10081 ggttgcgggt cgcgcgcagg cccccgccgc gcgcgaagag gaggtcggtg agcggcatcc
    10141 gcacgtggta ggccgccacg gacgagggca cgtccagaat gctcggcgtg tccaggaaga
    10201 acggcagttc ggctgcgagg tagtcgaaac aggcctgcaa ctgggcgtcc gtcatggatt
    10261 cgccttccgg cagcttgggg ccgacgaaat gaacggccat ctcctcgcac cccttgcgga
    10321 attcgccgtc ggtctccagg aaatgcagga cgcgtcggtg aaggagtcgg taaacggagt
    10381 tcgactggaa gtcggacagt gcgctcaccc gtatgcccgg atgcgcccgg acggattcct
    10441 ccacgccctt caggacccgc cggcggacgg ccttgatctc cttcgaggcc cgcctggcgg
    10501 cgtgttcgcg gctgtacccg aacgccgcga acatgcggtc cacgtgcagg tccgcgtaga
    10561 cgaagtcgac ctgtgcgaaa cgcgatgagg cccagcgggc caggcttccg atgcggtcgg
    10621 agccgaagta gctgtttccg gggctgactc cgatgagcac atggtcgccg tcctcccata
    10681 tgtgccggca ggcgcgggtg aaggggagga cttcgaatga tgcgtcggct gtgatcgcca
    10741 cctgtgatca cctttgtttg ccgcatgtcc ctgggagccc tgcgctcctg gtgtggcggc
    10801 aatgccggta cgttatgcgg tgaccccgga acgtgacaag cccacgtccg gtttcccggc
    10861 cggaatcagt gattccgggt tacggcgcgg taattgaatt tgtttctgcc gggcgaacgg
    10921 gacccggagt ccgcagccgc ccgggccggc gctaccctga gccggtcaga cagcaccgag
    10981 aaggggtgga tcccaagtgg cggacatcga gagcgcgcgg gcgacgttcg gcaggttcga
    11041 cgcggacggc gacggcttcg tgacggccga cgagttccgt caggccatgg cccagatggg
    11101 cgacccgttc gtgacgggcc cggtcgcgga cgccgtgatc gccgcccggg acaccgacgc
    11161 cgacggcctg atgagcttcg acgagttctg ggcgtccctg aacaagtgag ccgtgcgccg
    11221 tgcccccgcc cgcccgatcc gggcaggcgg gggcacggcc gcgtacagcc cgtcagggcg
    11281 cgcccgcccc gtcggcgggc cccgcggcat ccggatcgcc gcccgggagg tccgccatgc
    11341 cgccgacctc ctccagggcc tcctccagcc agcgcagcca gaacgtctcc agcccgatgc
    11401 cgccgtgcag cacgagccgg cgcagccggt cctcgtcgga gtcccggccg ggcgggaagt
    11461 cccgctcctc gatggcctcg tagagcgcca gctgccggcg gtgcagctcc aggtgccgcc
    11521 gcagctcggc caggagaccg tccgtcccca ccacggccgc ggcgcggacg cgcagcagca
    11581 gcgggtcgcg gatggccttc gggtcctggc tcccgcccac ccagcgcgcc agctccccgc
    11641 tgccggcggg caggacctcg tacgccttcc gctgcccccg cacgggcccg tcgcccggca
    11701 gcgcccggat gtacccggcc tcctccagcc tgccgagctc ccggtagatc tgctggtgcg
    11761 tcgccgacca gaagtacccg atcgaccggt cgaaccggcg ggtcagctcc agccccgacg
    11821 agggcttctc cagcagggcg gtgaggatcg cgtgcggcag ggacatgccg ccatcctagg
    11881 gaggccggac ggcgggcagc ggggagcggc cgcccggcac ccctccggcg gcggggactc
    11941 agtgccagga ggccagcgcc tccggcgtct tcgggccgag ggcgtccgcc gccagccggc
    12001 cgccggagcg caggaacgcc gccaccgccg gcgcccaggc ctgccgcagg cccgcccccg
    12061 ccagcagctc cgggtccgac agcagcgccg ccgccggacc gaagcggatc ccgtccgggg
    12121 tcagcaccgc ggcgtcgtcc gcccagcgca ccgccaggtc gacgtcgtgc gtcgccatca
    12181 ccaccgtcgt ccccgcggcg cgcagccccg ccagggcgtc cagcagccgc tcctgcccct
    12241 ccgggtccag gccggccgtc ggctcgtcca ggatcagcac ccgcggggcc atcgcgaccg
    12301 ccccggcgat cgccgcccgt ttgcgctgcc cgtacgacag caggtgcgtc ggccggtccc
    12361 gcagcgcggt gatgccgagt gcggacagcg cctccccgac gcgtgcccgc acctcggcgg
    12421 ccgacaggcc caggttcatc gggccgaagg agacgtcctg ttcgacggag gccgcgaaca
    12481 gctggtcgtc cgggtcctgg acgaccagct ggaccgcctt gcgcaggcgg gtcaggcccg
    12541 cccggtcgta cgccaccggc gtcccgtcca gcaggagttc cccggaggcc ggccgcagcc
    12601 cgccgctcag cagccgcatc agcgtggtct tgccgctgcc gttgcggccc agcaggacca
    12661 gcgcccggct ctcggcgatg gagaagtcca cgccgtccag caccgccggg ccgtcctcgt
    12721 aggcgtagcc cgctccggcc agttccacca acgggttcac gagtacagcc cctccagggt
    12781 gtaggtcagc gcgaccaggc ccgcgatgag ggccgccgag gccgcgagga agcgccggga
    12841 cagggcggcc tcgggaacga gcacgcgcag cgccccgtcg tacccgcgcc cggcgaggcc
    12901 ggactggagc cgcgccgccc ggtcgaaggc ccggacgaac gaggtcgctg cgagcccggc
    12961 cagcgaccgc cacaccgcgg cccggtccgc gtgccccagc cgggccgcct gggcccgccg
    13021 gacctgcgcc agcgagtcca gcagcaggaa cccgatgcgg tacatcacga gcgccacgtc
    13081 caccacgggc gccggcaccc cggcccggac cagccggggc agcacgtccg agacgggggt
    13141 ggtgaacgcg aacagcagga cgcccaggga cgcggcggac gtgcgcagca gcagttcgcc
    13201 cgcgtgccgc ggcccgtccg gtgcgagcga cacgggcccg gccgcgccgc cgaccgcgaa
    13261 gagcagcggc agcgcaccgg tgaagcagaa gcccagcggg atccggaagg cccgccacag
    13321 ctgccgcccg gcgacgcccg ccggcccgag caggacggcg agggtcgccg cggcgaccag
    13381 gggcccgccg ggccagggcg gaaggcacac ggccgtgacc gtcagcccga gccccagcag
    13441 ggccttctcc agggggtgcc ggccgcgcca gcggctgccg tgcgcagcca cgtcgatcgg
    13501 cagcaccggc tagccctccg cgcgcgtgtc gcccggggtg cccgatccga tggccgccgc
    13561 ggccgcggcg ccctggcggc ggcccctgcg caccccgaag tagtaggcga ggacgcccgc
    13621 gccgagggcc gcctggaggg cgaacagggc cgactcgacc tcgccggacg gcggctcgta
    13681 cagcggggtg aaccacggct cgtagtcggg cctgagctcg gtgatcgccg cttcggcctg
    13741 ggcgtcggcg ccggcgaacg gctcctccct gccctcgccg aggcccagcg cgagggggag
    13801 caccgcgagg gcggcgacca cgagcagcag cagggtgttg atcttcgcgt tccggctcat
    13861 gcccatcacg ccgccgcctt ccggtcggag cggccggcga gcttggcgac gcccagccgg
    13921 accaggtcgg acttgctgga ctgcatcagc agccgcatca ccaggaccgt cagcaggcct
    13981 tcgctgaccg ccagcgggat ctgggtgacg gcgaagatgc cgccgaactt cgcgagggcg
    14041 ccggcgacgc cgctgcccgg gtcggggaag gcgagcgcca gctgcacgga ggtgacgcag
    14101 taggtgacca ggtccgcggt gaaggcgccg aagaacacgg acaccatcag cggggcgccg
    14161 gaccgccgca gcagcaggta gaccccgaag cccgcccacg ggccggcgat cgccattgag
    14221 aagacgttgg cgccgagggt ggtcaggccg ccgtgcgcga gcagcagcgc ctggaagagc
    14281 agggtgatcg tgccgagcac cgccatgatc ggcggccgga acaggatcgc cccgagcccg
    14341 gtccccgtcg ggtgcgagca actgcccgtc acagagggga tcttcagggc ggaaaggacg
    14401 aaggtgaagg ctccggacgc gcccaggagc agggtgctct ccgggttctc cttcacctcg
    14461 cgggtgagtg cgcggacgcc gtggacgacg aagggagcgg acgcggcgcc ccaggcggcc
    14521 gcgtgcagcg ggggcagaaa cccctcggct atgtgcatgt gtggggagac ctctccagca
    14581 cctcgtggat ggacagcacg ccccggccgg tctcctggct cacgggtcat gccgccctgg
    14641 ctccgccttc ccgggcggtg cggatcaccc cgcgccgccc agtggcttcc cgcaggagtg
    14701 gagccggact tcccgttcac agtggcgagg gccgcaccgg tcttccaccg gtttcccgaa
    14761 caccaaggcc cgctgaccct aatggcccgc acggacccgg aacaagccgg tgtgggcgag
    14821 cgcacgcccg agccggattc cgcttccggg ccgtccggcg gcgtacgcgc tctccgggcg
    14881 cagccggagc cgccgttccg ccgcgtgttt ccgcccttgc ggcgcccgtt cggtcccccg
    14941 gagagccccc ggcgcacggc ccggcgtgat tccgccgccg tgctcccacc ggcgtgcgcc
    15001 ggagccgcgg aacgggcccg ccccccggac gggtgccgtc cgctggcggg gccggcgggg
    15061 gccgcgcagg gtggagccgt ggccgccgaa cccgacaccg cgaacccgta cgactactcc
    15121 gacctcaccg ccctcttcgt caactgcacg ctcaagcgct cgccggagac cagcaacacc
    15181 gagggcctca tcgaccgcag ccgcgccgtc atggagtcgg ccggcgcccg cacctcggtc
    15241 gtccgcgccg tcgaccacga catcgccacc ggcgtctggc cggacatgac cgagcacggc
    15301 tgggagacgg accagtggcc cgtcttgtac agccgggtca tggacgcgga catcctggtc
    15361 ctgtgcgggc cgatctggct cggcgacaac agctccgtca tgaagcaggt gatcgagcgc
    15421 ctctacgcct gctcctccct gctgaacgag cacggccagt acgcctacta cggccgggtc
    15481 ggcggggcgc tcgtcaccgg caacgaggac ggcgtcaagc actgcgcgat gaacatcctg
    15541 tacagcctcc agcaccttgg ctacgcgatc ccgccgcagg ccgacgccgg ctggatcggc
    15601 gaggccgggc ccggcccctc ctacctggac ccgggatcgg gcggccccga gaacgacttc
    15661 accaaccgca acaccgcctt catgtcgtgg aacctcatgc acctcgcggc gctgctcaag
    15721 cgctccggcg gcatcccggc ccacggcaac cagcgctcgc tgtgggacgc cggctgccgc
    15781 ttcgacttcc ccaacccgga acaccgctga cgggcggccc ggccggtgcc ggtcagccgc
    15841 agcacacgtt ccggtgcgcg atgtcgacca cgaaccggtc gggcgagcgg agcgtgaacg
    15901 ccttgtacga gggcctgctg tcgaaggcgg cgccgaaggt gacgtacccc tcgaagtcgc
    15961 cggtcatggc gaggcccttg agcgcgggca ggttcgtccg gaccagcttg ggcccgcggt
    16021 aggtgccctc gccggagcgc aggtgcgccg cggcggggtg cagccggatc tggaggaagt
    16081 gcttcccggc cagcgggacg ggcgccccgg agccgtcctg gtggagcgcg gggacgcggg
    16141 tgacgtccgc gtcgggcacg taccccttca ggtcgatgac gatccggtca tacgcgcagt
    16201 gcccggccca gcgggcgccc acgacgagcg gggtggccgg ggcccggccg gagggggccg
    16261 cggccgtgga ggccggtgcg gcgagggcga gggcggcggt gagcaggact ccggtggcca
    16321 gggccgcggt ccgccggcgg cgcaggtggt tcatggcgtc ccccctgttc tttcgagaga
    16381 cggggacagg ttgtcgctcc tgaagacacg ccgtgcatgc ccatggttgc agcaaaacgc
    16441 aaaaaaatcg ggcagaaggg gtgaacctgg tggggtccgc cccttctgcc cgcgtccgcc
    16501 cggctcagcc ggccggtgtc agcactcgat gacgttgacg gcgaggccgc cgcgcgccgt
    16561 ctccttgtac ttgatcttca tgtcggcgcc ggtctccttc atggtcttga tgaccttgtc
    16621 gagggagacc ttgtgggagc cgtcgccgcg catcgccatc ttcgccgccg tgacggcctt
    16681 caccgccgcc atgccgttgc gctcgatgca cgggatctgc accaggccgc cgaccgggtc
    16741 gcaggtcagg cccaggttgt gctccatgcc gatctcggcc gcgttctcca cctgctccgg
    16801 ggtgccgccc aggacctccg cgagcgcgcc ggccgccatg gagcaggccg acccgacctc
    16861 gccctggcag ccgacctcgg cgcccgagat cgaggcgttc tccttgaaca gcatgccgat
    16921 cgcgcccgcg gcgaggagga agcggaccac gccgtcctcg tccgcgccgg gcacgaagtt
    16981 cacgtagtag tgcaggacgg ccggcaggac gcccgccgcg ccgttcgtcg gggccgtcac
    17041 gacgcggccg cccgccgcgt tctcctcgtt gaccgccatg gcgtagatcg tcgtccactc
    17101 gctgcggtgc atcatcgggt cgccctcggt gcgcagctgc cgcgccgtgg ccgcggcccg
    17161 gcgcttgacg cgcaggccgc cggggaggat gccctcgcgg gacatgccgc gcgacacaca
    17221 ggcctgcatg acccgccaga tctccaggag gccctcgcgg atctcctcct ccgtgcgcca
    17281 ggccttctcg ttctccagca tcagggagga gatcgacagg ccggtctcct tggcgaggcg
    17341 cagcatctcg tcgcccgagc ggaaggggta cttcagcacg gtgtcgtcga gcttgatccg
    17401 gtcctcgccg accgcgtcct cgtcgaccac gaagccgccg ccgaccgagt agtacgtctt
    17461 ctccagcagc ggcgtgccgg cggcgtcgta cgcgaagagg gtcatgccgt tcgcgtggta
    17521 cggcagggag cggcggcggt gcaggacgag ctggttcggc tcgtcgaagg cgatctcgtg
    17581 cgcgctccct atctccgtgc ccagcaggcg cagccggccc gtgctgcgga tgcgctccac
    17641 ctcgtcgtcg gcggtctcga cgtccacggt ccgcggggag tggccctcca ggcccagcag
    17701 caccgccttg ggcgtgccgt ggccgtggcc ggtcgcgccg agcgagccgt acagctccgc
    17761 gcggacggac gcggtctggg cgagcaggcc gtccttcttc agccggttga cgaacatgcg
    17821 ggcggcgcgc atcgggccga cggtgtgcga gctggacgga ccgatgccga tcgagaagag
    17881 atcgaagacg gaaatggcca cggtggcgga ctccagggtc acccccgcgg tggcggggag
    17941 cgaaccgccg cgtcgctctc gcagcggggg cgaggcggcc ggcggagggg gcggactttg
    18001 cagggattgc gggcaaagat cgcctcgtgg gcgcccttgc ccggttaatc agcgtacgtc
    18061 aggtcgtgag ggggccggtg acgccggcct gtacggcggc ttgcgggccg gtggcgcgcc
    18121 gcgccgccgg ccccggccat gggaaaggcc cggccctgtg ggacacaagg ccgggccttt
    18181 ggagccgcgg ccttacagcg acgggtacag cgggtgcttc gcggcgagcg ccgagacgcg
    18241 cgccttgagg gcctcgccgt cgtaggacgg cttcagggcc tcggcgatga cgtcggcgac
    18301 ctcggtgaag tcctcggcgc cgaaaccgcg ggtggccagg gccggcgtgc cgatccgcag
    18361 gcccgaggtg accatcgggg gccgcgggtc gttcgggatg gcgttgcggt tgacggtgat
    18421 gccgatctcg tggaggcggt cctcggcctg ctggccgtcc agctccgagt tgcgcaggtc
    18481 caccaggacc aggtgcacgt cggtgccgcc ggagaggacg tccacgccga cggccttgac
    18541 gtcgtcctgc accaggcgct cggcgatgat cttcgcgccg gccagggtgc gctcctggcg
    18601 ctccttgaac tcgggcgagg ccgccacctt gaaggagacc gccttggcgg cgatcacgtg
    18661 ctccagcggg ccgccctgct ggccggggaa gaccgcggag ttgatcttct tggccagttc
    18721 ctgcgtcgac aggatgacac cgccgcgcgg accgccgagg gtcttgtgcg tggtggtggt
    18781 gacgacgtgg gcgtgcggca ccgggttcgg gtgcaggccc gcggcgacca ggccggcgaa
    18841 gtgcgccatg tcgaccatca ggtacgcgcc gacctcgtcc gcgatgcggc ggaaggcggc
    18901 gaagtccagc tggcgcgggt acgcggacca gccggcgacg atcagctgcg gcttggactc
    18961 cttggcgagg cgctcgacct cggccatgtc gacctggccg tcctcgccga cgtggtacgg
    19021 gaccacgttg tagagcttgc cggagaagtt gatcttcatg ccgtgggtca ggtgaccgcc
    19081 gtgggccagg ttcaggccca tgatcgtgtc gcccggcttc agcagcgcga acatcgcggc
    19141 ggcgttggcc tgcgcaccgg agtgcggctg gacgttcgcg gcctcggcgc cgaagagcgc
    19201 cttgatccgg tcgatggcga tctgctcgac gacgtcgacg tgctcgcagc cgccgtagta
    19261 gcggcggccc gggtagccct cggcgtactt gttggtcagg accgagccct gggcctccat
    19321 gacggcgacc ggagcgaagt tctccgacgc gatcatctcc agggtggact gctggcgtgc
    19381 gagctcggcg tcgacggcgg cggcgacgtc ggggtcgagc tcgtggagcg gggtgttcag
    19441 aacggacatc ttcggtccct ggttcagttg ccggaaaggg tgagctgctc gtactcggcg
    19501 gcggagagca ggtcctccgg ctcctccgac acgcgcacct tgaagagcca cccgccctcg
    19561 aagggggcgc tgttgacgag cgacgggtcg tccacgacgt cctggttggc ctcgacgacc
    19621 tcgcccgtga cgggggagta caggtcgctg accgacttgg tcgactccag ctcgccgcag
    19681 gtctcgcccg cggtcacggt gtcgccgacg gcggggagct gggcgtagac gacgtcaccg
    19741 agcgcgttgg ccgcgaacgc ggtgatgccg accgtcgcga cgccgtcctc ggcggccgac
    19801 agccactcgt gctccttgct gtaacgcagc tgctgggggt tgctcatggc ctgattctcc
    19861 tggatgcggg ggagtgcgga cgaacggttg tcttgcctgt cgagactcgg cccggcaggc
    19921 gggagcgtgc gggcgtgccg acgcgtcggg gtctacttct gccgcttgta gaagggcagg
    19981 gcgacgacct cgtacggctc atgggtaccg cggatgtcca cgccgacgcc ggaggcgccc
    20041 ggctcggcgt gtgccgcgtc gacgtacgcc atggcgatcg gcttgccgag agtcggggac
    20101 ggggcgccgg aggtgacctc gccgaccacc tggccgccgg ccacgacggg gaacccggcg
    20161 cgcgggaccc ggcggccctc ggcgaccagg ccgaccagct tgcgcggcgg gttcgaggcg
    20221 gagcgctcgg cagcggcctc cagggcggcg cggcccacga agtcgccctc cttctcgaac
    20281 ttcacgaccc ggcccaggcc cgcgtcgaac ggggtcaggg aggtggtcag ctcgtgcccg
    20341 tacagcggca tgcccgcctc caggcgcagc gtgtcgcggc aggacaggcc gcacggcacc
    20401 aggccgcggc cctcgccggc cttgctcagc gcctgccaca gctccacggc gtgcgcgggg
    20461 gagacgaaga gctcgaagcc gtcctcgccg gtgtagccgg tgcgggcgat cagcgcgggg
    20521 acgcccgcga ccgtgcccgg caggccggcg tagtacttca ggccgtccag gtcggcgtcc
    20581 gtcagcgagg ccaggatggc gggcgactcc ggcccctgca ccgcgatcag cgcgtacgcg
    20641 tcgcggtcgt cgcggacctc ggtgtcgaag ccggccgcgc gctcggtgag ggcgtccagg
    20701 acgacctggg cgttcgaggc gttggcgacg accatgtact c
//
