LOCUS       NZ_QOIM01000062         8542 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces reniochalinae strain LHW50302
            NODE_36_length_8542_cov_19.7406_ID_71, whole genome shotgun
            sequence.
ACCESSION   NZ_QOIM01000062
VERSION     NZ_QOIM01000062.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces reniochalinae
  ORGANISM  Streptomyces reniochalinae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8542)
  AUTHORS   Li,L.
  TITLE     Streptomyces reniochalinae sp. nov. and Streptomyces diacarnus sp.
            nov. from marine sponges
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8542)
  AUTHORS   Li,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUN-2018) Department of Pharmacy, Ren Ji Hospital
            School of Medicine, Shanghai Jiao Tong University, Pujian, Pudong,
            Shanghai 200127, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-FEB-2016
            Assembly Method                   :: A5-misseq v. MARCH-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003323735.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 01:54:27
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,751
            CDSs (total)                      :: 6,669
            Genes (coding)                    :: 6,475
            CDSs (with protein)               :: 6,475
            Genes (RNA)                       :: 82
            rRNAs                             :: 6, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 4, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 66 of 194
            Pseudo Genes (incomplete)         :: 154 of 194
            Pseudo Genes (internal stop)      :: 16 of 194
            Pseudo Genes (multiple problems)  :: 41 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:03:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 8542
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QOIM01000062.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     gene            complement(<1..2679)
                     /locus_tag="DQ392_RS33875"
                     /old_locus_tag="DQ392_33855"
     CDS             complement(<1..2679)
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (2-30). E-value:
                     2.1e-16. Score: 51.2. Matches aSDomain:
                     nrpspksdomains_DQ392_RS33875_PKS_Docking_Nterm.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (34-458). E-value:
                     7.2e-181. Score: 593.6. Matches aSDomain:
                     nrpspksdomains_DQ392_RS33875_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (568-867). E-value: 3.9e-103.
                     Score: 336.8. Matches aSDomain:
                     nrpspksdomains_DQ392_RS33875_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491085.1"
                     /locus_tag="DQ392_RS33875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_33855"
                     /product="type I polyketide synthase"
                     /protein_id="WP_114019536.1"
                     /sec_met_domain="mod_KS (E-value: 2e-224, bitscore: 732.8,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2.6e-91, bitscore:
                     293.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 2e-104, bitscore: 336.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEDKLRDYLKRVTADLHQARRRLDEYESQSREPIAIVGMACRFP
                     GDADSPEALWELVSQSRESVSGFPDDRGWPDDLYDPDPEAHGKTYSARGNFVQGAARFD
                     AEFFGISPREALAMDPQQRLLLETAWEALEHASLVPGELHGTDAGVFIGAAGAEYASLR
                     DGGPAAADGYLLTGLLTSVASGRLAYTLGLEGPAVTIDTACSSSLTAMHLAAQALRNGE
                     TRLALAGGATIMSHPGVFVEFSRQRGLSPDGRCRAFAASADGTAWGEGVGLLVLERLSD
                     AQRNGHPVLAVIRGSAVNQDGASNGLTAPNGPSQERVIRAALANADLPASGVDVVEAHG
                     TGTRLGDPIEAQALLATYGQDRPDDRPLWLGSVKSNIGHTQAAAGVAGVIKMVEAMRHG
                     VLPRTLHVDEPTPHVDWSVGGVRLLTESTAWPQTGRPRRAAVSSFGISGTNAHVVLEAP
                     PAVEGALSEGSGVEEPGGVVSWVLSAKSQVALRAQAARLEKHVEGHPDLGASAVAGALA
                     TTRTVFDHRAVVTGTDRDELIEGLRALAQDETRPGVVCPGQAADPSGRTAFLFSGQGSQ
                     RAGGGAGLYAAEPVFKAAVDEACQHLDPLLGRSLVEVMCAEPGTEAARLLDHTRYTQPA
                     LFALHLGLHRLLEHHGLKPDFLAGHSVGEISAAHCAGVFSLADAARLIVKRAELMGQLP
                     PGAMASIQATADELTPHLSDQVCIAAYNTPRHTVISGDPDAVADIVEAFTAQGRRVKTL
                     ATEHAFHSPHTDTILDAFREAAEQVTYHPPHTPLISNLTGRPAETEQVTTPAYWSAHIR
                     QPVRFADMLTTLANAGTNTYLDLGPTPTLAPLIHHTLTSDNNSETDTPTVLTTLHPDHH
                     DTHALTTTLAHAHTTTHPLTWH"
     source          1..8542
                     /collected_by="Lei Li"
                     /collection_date="2015-04-30"
                     /country="China: Xisha"
                     /culture_collection="CCTCC:AA 2018013"
                     /culture_collection="DSM:106194"
                     /db_xref="taxon:2250578"
                     /identified_by="Lei Li"
                     /isolation_source="marine sponge"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces reniochalinae"
                     /strain="LHW50302"
                     /submitter_seqid="NODE_36_length_8542_cov_19.7406_ID_71"
                     /type_material="type strain of Streptomyces reniochalinae"
     region          1..8542
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..8542
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..8542
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[<0:2679](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(<1..2679)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     aSDomain        complement(79..975)
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS33875_PKS_AT.1"
                     /evalue="3.90E-103"
                     /label="DQ392_RS33875_PKS_AT.1"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="867"
                     /protein_start="568"
                     /score="336.8"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFSGQGSQRAGGGAGLYAAEPVFKAAVDEACQHLDPLLGRSLVEV
                     MCAEPGTEAARLLDHTRYTQPALFALHLGLHRLLEHHGLKPDFLAGHSVGEISAAHCAG
                     VFSLADAARLIVKRAELMGQLPPGAMASIQATADELTPHLSDQVCIAAYNTPRHTVISG
                     DPDAVADIVEAFTAQGRRVKTLATEHAFHSPHTDTILDAFREAAEQVTYHPPHTPLISN
                     LTGRPAETEQVTTPAYWSAHIRQPVRFADMLTTLANAGTNTYLDLGPTPTLAPLIHHTL
                     TSDNNSETDTPTVLTTLH"
     aSModule        complement(79..2577)
                     /domains="nrpspksdomains_DQ392_RS33875_PKS_KS.1"
                     /domains="nrpspksdomains_DQ392_RS33875_PKS_AT.1"
                     /incomplete
                     /locus_tags="DQ392_RS33875"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(229..264)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33875_0008"
                     /evalue="2.00E-05"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="817"
                     /protein_start="805"
                     /score="17.8"
                     /tool="antismash"
                     /translation="YWSAHIRQPVRF"
     CDS_motif       complement(487..525)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33875_0007"
                     /evalue="2.10E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="731"
                     /protein_start="718"
                     /score="14.4"
                     /tool="antismash"
                     /translation="AAYNTPRHTVISG"
     CDS_motif       complement(610..729)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33875_0006"
                     /evalue="1.80E-20"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="690"
                     /protein_start="650"
                     /score="65.2"
                     /tool="antismash"
                     /translation="GLKPDFLAGHSVGEISAAHCAGVFSLADAARLIVKRAELM"
     CDS_motif       complement(925..978)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33875_0005"
                     /evalue="1.70E-03"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="585"
                     /protein_start="567"
                     /score="11.2"
                     /tool="antismash"
                     /translation="FLFSGQGSQRAGGGAGLY"
     aSDomain        complement(1306..2577)
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS33875_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="7.20E-181"
                     /label="DQ392_RS33875_PKS_KS.1"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="458"
                     /protein_start="34"
                     /score="593.6"
                     /tool="antismash"
                     /translation="IAIVGMACRFPGDADSPEALWELVSQSRESVSGFPDDRGWPDDLY
                     DPDPEAHGKTYSARGNFVQGAARFDAEFFGISPREALAMDPQQRLLLETAWEALEHASL
                     VPGELHGTDAGVFIGAAGAEYASLRDGGPAAADGYLLTGLLTSVASGRLAYTLGLEGPA
                     VTIDTACSSSLTAMHLAAQALRNGETRLALAGGATIMSHPGVFVEFSRQRGLSPDGRCR
                     AFAASADGTAWGEGVGLLVLERLSDAQRNGHPVLAVIRGSAVNQDGASNGLTAPNGPSQ
                     ERVIRAALANADLPASGVDVVEAHGTGTRLGDPIEAQALLATYGQDRPDDRPLWLGSVK
                     SNIGHTQAAAGVAGVIKMVEAMRHGVLPRTLHVDEPTPHVDWSVGGVRLLTESTAWPQT
                     GRPRRAAVSSFGISGTNAHVVLEAP"
     CDS_motif       complement(1525..1569)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33875_0004"
                     /evalue="2.80E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="385"
                     /protein_start="370"
                     /score="13.1"
                     /tool="antismash"
                     /translation="GSVKSNIGHTQAAAG"
     CDS_motif       complement(1630..1674)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33875_0003"
                     /evalue="1.30E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="350"
                     /protein_start="335"
                     /score="13.9"
                     /tool="antismash"
                     /translation="VEAHGTGTRLGDPIE"
     CDS_motif       complement(1735..1755)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33875_0002"
                     /evalue="9.90E+01"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="315"
                     /protein_start="308"
                     /score="-2.9"
                     /tool="antismash"
                     /translation="APNGPSQ"
     CDS_motif       complement(2050..2097)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33875_0001"
                     /evalue="1.00E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="210"
                     /protein_start="194"
                     /score="20.6"
                     /tool="antismash"
                     /translation="GPAVTIDTACSSSLTA"
     aSDomain        complement(2590..2673)
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS33875_PKS_Docking_Nterm.
                     1"
                     /evalue="2.10E-16"
                     /label="DQ392_RS33875_PKS_Docking_Nterm.1"
                     /locus_tag="DQ392_RS33875"
                     /protein_end="30"
                     /protein_start="2"
                     /score="51.2"
                     /tool="antismash"
                     /translation="EDKLRDYLKRVTADLHQARRRLDEYESQ"
     gene            complement(2896..4194)
                     /locus_tag="DQ392_RS33880"
                     /old_locus_tag="DQ392_33860"
     CDS             complement(2896..4194)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="DQ392_RS33880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_33860"
                     /product="cytochrome P450"
                     /protein_id="WP_114019537.1"
                     /sec_met_domain="p450 (E-value: 1.9e-21, bitscore: 63.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVEPDAVEGLPTARGCPFSPPAELTELSATRPLARMSYPDGHMG
                     WLVTSHFLARQILASQDFSARHDLRHSPIPTMLTPTPAPPGAFIGMDPPEHTRYRKPLN
                     QYFTVRRIRQLEPAIERTTREHLNTMEKTGAPTDLMRAFALPIPVAVISELLGSTPEIN
                     EELQRLRAVSMDPRSPAEDVGASVKATHELMQNLVAYKRDTPGDDLLTKLIGDGELDDA
                     ELTGLALMMLIAGHETTAQMIGLSMYYLLRHEEIRDRLIGGPVLTDEAVNELLRCLSAV
                     QFVTRVALTDVELGGVTVRKGEACTISLPAVNRDARAFDEPDLFKAVGDTAETPQASRH
                     APASGSPQASRHAPASGSPQASGQAPASGSHLTFGHGIHQCIGHNLARSEMKIAIGAVW
                     QRFPALRLASDDAEITTREAFNTYGLDRLPVEW"
     gene            complement(4226..8344)
                     /locus_tag="DQ392_RS33885"
                     /old_locus_tag="DQ392_33865"
     CDS             complement(4226..8344)
                     /NRPS_PKS="Domain: PKS_DH (12-184). E-value: 3.5e-49.
                     Score: 159.3. Matches aSDomain:
                     nrpspksdomains_DQ392_RS33885_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_ER (606-912). E-value: 9.1e-116.
                     Score: 378.3. Matches aSDomain:
                     nrpspksdomains_DQ392_RS33885_PKS_ER.1"
                     /NRPS_PKS="Domain: PKS_KR (921-1101). E-value: 1.8e-64.
                     Score: 209.0. Matches aSDomain:
                     nrpspksdomains_DQ392_RS33885_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (1205-1291). E-value: 2.8e-28.
                     Score: 90.1. Matches aSDomain:
                     nrpspksdomains_DQ392_RS33885_PKS_PP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (1300-1372). E-value:
                     8.7e-11. Score: 34.5. Matches aSDomain:
                     nrpspksdomains_DQ392_RS33885_PKS_Docking_Cterm.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF020243.4"
                     /locus_tag="DQ392_RS33885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_33865"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_342774990.1"
                     /sec_met_domain="ADH_N (E-value: 8.3e-11, bitscore: 29.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.7e-16, bitscore:
                     47.1, seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3.9e-68, bitscore:
                     216.5, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.9e-13, bitscore:
                     36.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVVGSGLNAPGHPLLSAHVDLPSGGHVFTTRLGPGSHRWLADHA
                     VGDVVVLPGTAFVELVTHAARVSGMACVEELTLHTPVVLEGDGALRLQMVVEPPDETGR
                     RQVLVHAREADTGTDSDSDSGEEGRPWVCHAEAVLTTASEADTPPAPVRLPADAQPVDV
                     QELSLELAEAGMDYGPAFQGLERAWRHGQDICADVTLPQTLEPGGYGIHPALLDAALHP
                     LALLTRQAGEEAVLRLPYSWRDVTVHATGATELRVRLSATAEDTAALTVSTLDGEPVVT
                     VGGLTVRPADVKPADRLRARHDEPPHLAWTPLLAPVSAAERVVGEPSRTVTLLGVLPEA
                     AAAPAAAAAEPRSLPTDIVHSAAHSDVRFDVHSDVRAFLDRLAEGAPVPREVFAVFPPV
                     PHSDDDAGAVGRRDRRSAPAAADPVSAAHAVTGEALDLVQTWLSDERLVDCRLVVVTEN
                     AVSVENNGAAVDPAAASLWGLLRSAQREHPGRFALLDVDLNADMDLYADMGPSAAVDPS
                     AAVDPNVDMAVNGEPGVDVDDSAAPRRRPVDVAAVLGGDVAPVLAGGEEDQVAVRKGDL
                     YVPRLVRSGACPSLSPPADEDAWRLDVRTPGTLDELALLAFHDAEKPLGEGQVRIAVRA
                     AGVNYRDVLIALGMYPGEEIIGGEGAGVVTEVGAGVTGLMVGDRVMGLIPGAMGPVAVA
                     DHRLVRRVPAGWSFAQAAAVPVVFLTAYYGLADLAGVRAGERLLVHAAAGGVGTAALQL
                     ARHWGLEVYGTASRGKWDFLRSQGLDDRHIGDSRSLAFQEVFAQATDGAGVDVVLNSLA
                     HEFVDASLRLLPRGGRFLEMGKTDIRSADEIAAASPGVRYRAFDMTDAGPDRIGAMLDE
                     LIALFESGVLRPPPVTTWDVRQAGEAFRCLREAKHVGKVVLTVPAPLSLSGTVLITGGT
                     GALGRALARHLVARHGVRHLLLTSRRGRDAEGAAEAEAELAALGAEVTVASCDVAVPSA
                     VAGLLEGIPAAHPLTAVFHTAGVLDDATVAALTPDALHAVLRPKADGAWHLHRATEHLD
                     LSAFVLFSSVAGVLGSPGQANYAAANTFLDALAHHRRERGLPAVSLAWGLWGEAGGMTA
                     HLEGSALSRMRGTGIRAMSHQEALALLDSALATGRVASVPARFVPPPSTPDGSGTQATR
                     LPVLRDLFDVRGPGRGVGRRTSPGVAVPASKRGGTWREDLAGLTEDEQREQLTRLVLTE
                     AAAVLGHSELDAFGHNRPLKEAGFDSLTAVELRNRLATAVELRLPASLIYDHPTPEAVA
                     DHLMKQLAPEQGDFLHHVLSDIQRLESSVLSEEPGPEARTEIAAHLKEWLRKLTSGAEP
                     QASGEEDDVYQQMASSTDDEIFAFIDNEL"
     aSDomain        complement(4229..4444)
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS33885_PKS_Docking_Cterm.
                     1"
                     /evalue="8.70E-11"
                     /label="DQ392_RS33885_PKS_Docking_Cterm.1"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="1372"
                     /protein_start="1300"
                     /score="34.5"
                     /tool="antismash"
                     /translation="HVLSDIQRLESSVLSEEPGPEARTEIAAHLKEWLRKLTSGAEPQA
                     SGEEDDVYQQMASSTDDEIFAFIDNEL"
     aSDomain        complement(4472..4729)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS33885_PKS_PP.1"
                     /evalue="2.80E-28"
                     /label="DQ392_RS33885_PKS_PP.1"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="1291"
                     /protein_start="1205"
                     /score="90.1"
                     /tool="antismash"
                     /translation="LAGLTEDEQREQLTRLVLTEAAAVLGHSELDAFGHNRPLKEAGFD
                     SLTAVELRNRLATAVELRLPASLIYDHPTPEAVADHLMKQL"
     aSModule        complement(4472..8308)
                     /domains="nrpspksdomains_DQ392_RS33885_PKS_DH.1"
                     /domains="nrpspksdomains_DQ392_RS33885_PKS_ER.1"
                     /domains="nrpspksdomains_DQ392_RS33885_PKS_KR.1"
                     /domains="nrpspksdomains_DQ392_RS33885_PKS_PP.1"
                     /incomplete
                     /locus_tags="DQ392_RS33885"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(5042..5581)
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS33885_PKS_KR.1"
                     /evalue="1.80E-64"
                     /label="DQ392_RS33885_PKS_KR.1"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="1101"
                     /protein_start="921"
                     /score="209.0"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GTVLITGGTGALGRALARHLVARHGVRHLLLTSRRGRDAEGAAEA
                     EAELAALGAEVTVASCDVAVPSAVAGLLEGIPAAHPLTAVFHTAGVLDDATVAALTPDA
                     LHAVLRPKADGAWHLHRATEHLDLSAFVLFSSVAGVLGSPGQANYAAANTFLDALAHHR
                     RERGLPAVSLAWGLWGE"
     CDS_motif       complement(5090..5194)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0011"
                     /evalue="1.70E-23"
                     /label="PKSI-KR_m4"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="1085"
                     /protein_start="1050"
                     /score="75.3"
                     /tool="antismash"
                     /translation="AFVLFSSVAGVLGSPGQANYAAANTFLDALAHHRR"
     CDS_motif       complement(5222..5251)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0010"
                     /evalue="2.40E-03"
                     /label="PKSI-KR_m3"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="1041"
                     /protein_start="1031"
                     /score="11.3"
                     /tool="antismash"
                     /translation="PKADGAWHLH"
     CDS_motif       complement(5477..5578)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0009"
                     /evalue="3.90E-11"
                     /label="PKSI-KR_m1"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="956"
                     /protein_start="922"
                     /score="35.5"
                     /tool="antismash"
                     /translation="TVLITGGTGALGRALARHLVARHGVRHLLLTSRR"
     CDS_motif       complement(5609..5656)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0008"
                     /evalue="4.40E-05"
                     /label="PKSI-ER_m9"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="912"
                     /protein_start="896"
                     /score="16.5"
                     /tool="antismash"
                     /translation="AFRCLREAKHVGKVVL"
     aSDomain        complement(5609..6526)
                     /ASF="ER domain putatively catalyzing 2S-configuration
                     product formation"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS33885_PKS_ER.1"
                     /evalue="9.10E-116"
                     /label="DQ392_RS33885_PKS_ER.1"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="912"
                     /protein_start="606"
                     /score="378.3"
                     /tool="antismash"
                     /translation="GTLDELALLAFHDAEKPLGEGQVRIAVRAAGVNYRDVLIALGMYP
                     GEEIIGGEGAGVVTEVGAGVTGLMVGDRVMGLIPGAMGPVAVADHRLVRRVPAGWSFAQ
                     AAAVPVVFLTAYYGLADLAGVRAGERLLVHAAAGGVGTAALQLARHWGLEVYGTASRGK
                     WDFLRSQGLDDRHIGDSRSLAFQEVFAQATDGAGVDVVLNSLAHEFVDASLRLLPRGGR
                     FLEMGKTDIRSADEIAAASPGVRYRAFDMTDAGPDRIGAMLDELIALFESGVLRPPPVT
                     TWDVRQAGEAFRCLREAKHVGKVVL"
     CDS_motif       complement(5912..5950)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0007"
                     /evalue="6.70E-05"
                     /label="PKSI-ER_m7"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="811"
                     /protein_start="798"
                     /score="15.3"
                     /tool="antismash"
                     /translation="TDGAGVDVVLNSL"
     CDS_motif       complement(6083..6145)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0006"
                     /evalue="4.40E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="754"
                     /protein_start="733"
                     /score="25.5"
                     /tool="antismash"
                     /translation="GERLLVHAAAGGVGTAALQLA"
     CDS_motif       complement(6170..6214)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0005"
                     /evalue="1.20E-05"
                     /label="PKSI-ER_m4"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="725"
                     /protein_start="710"
                     /score="18.5"
                     /tool="antismash"
                     /translation="AAAVPVVFLTAYYGL"
     CDS_motif       complement(6341..6379)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0004"
                     /evalue="3.90E-02"
                     /label="PKSI-ER_m2"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="668"
                     /protein_start="655"
                     /score="7.2"
                     /tool="antismash"
                     /translation="IGGEGAGVVTEVG"
     CDS_motif       complement(6401..6436)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0003"
                     /evalue="3.50E-03"
                     /label="PKSI-ER_m1"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="648"
                     /protein_start="636"
                     /score="10.5"
                     /tool="antismash"
                     /translation="GVNYRDVLIALG"
     CDS_motif       complement(6683..6706)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0002"
                     /evalue="8.90E+01"
                     /label="PKSI-ER_m1"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="554"
                     /protein_start="546"
                     /score="-2.6"
                     /tool="antismash"
                     /translation="VDVAAVLG"
     aSDomain        complement(7793..8308)
                     /ASF="catalytic triad H,G,P inconclusive"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS33885_PKS_DH.1"
                     /evalue="3.50E-49"
                     /label="DQ392_RS33885_PKS_DH.1"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="184"
                     /protein_start="12"
                     /score="159.3"
                     /tool="antismash"
                     /translation="HPLLSAHVDLPSGGHVFTTRLGPGSHRWLADHAVGDVVVLPGTAF
                     VELVTHAARVSGMACVEELTLHTPVVLEGDGALRLQMVVEPPDETGRRQVLVHAREADT
                     GTDSDSDSGEEGRPWVCHAEAVLTTASEADTPPAPVRLPADAQPVDVQELSLELAEAGM
                     DYGPAFQGL"
     CDS_motif       complement(8150..8227)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS33885_0001"
                     /evalue="2.80E-09"
                     /label="PKSI-DH_m2"
                     /locus_tag="DQ392_RS33885"
                     /protein_end="65"
                     /protein_start="39"
                     /score="29.4"
                     /tool="antismash"
                     /translation="WLADHAVGDVVVLPGTAFVELVTHAA"
ORIGIN
        1 gtgccaggtc agtgggtggg tggtggtgtg ggcgtgggcg agggtggtgg tgagggcgtg
       61 ggtgtcgtgg tggtcggggt ggagggtggt gaggacggtg ggggtgtctg tttcgctgtt
      121 gttgtcgctg gtgagggtgt ggtggatgag cggggcgagg gtgggggtgg ggccgaggtc
      181 gaggtaggtg tttgtgccgg cgttggcgag ggtggtgagc atgtccgcga accgcacggg
      241 ctggcggatg tgtgcgctcc agtaggcggg ggtcgtgacc tgctcggtct cggcgggtcg
      301 gccggtgagg ttggaaatga gcggggtgtg tggtgggtgg taggtgactt gctcggccgc
      361 ttcccggaag gcgtccagga tggtgtcggt gtggggggag tggaaggcgt gctcggtcgc
      421 gagtgtcttc accctccgcc cctgagccgt gaacgcctcc acgatgtccg cgacagcgtc
      481 cggatcgccg gagatgacgg tgtggcgggg tgtgttgtag gccgcgatac acacctgatc
      541 actgaggtgg ggggtgagtt cgtctgcggt ggcttggatg ctggccatcg cgccgggagg
      601 cagctgcccc atcagctctg cccgcttgac gatcaggcgt gcggcatccg cgagggagaa
      661 gacccccgcg cagtgggcag cgctgatctc ccccaccgag tgtccggcca ggaagtcggg
      721 cttgaggccg tggtgttcca ggaggcggtg caggcccagg tggagggcga acagtgcggg
      781 ttgggtgtag cgggtgtggt ccagcagcct ggccgcctca gtgcccggct cggcgcacat
      841 gacctccacc agcgaccggc ccaacagggg gtcgaggtgt tggcaggctt cgtcgaccgc
      901 cgccttgaac accggctcag cggcgtacag cccggcgccg ccccccgcgc gctgcgaacc
      961 ctgccccgag aacaggaacg ccgtccgccc cgaggggtca gcagcctgcc ccgggcacac
     1021 cacaccgggg cgtgtctcgt cttgggccag ggcgcgtagg ccctcgatca gctcgtcacg
     1081 gtccgtcccg gtgacgaccg cgcggtggtc gaagaccgta cgggtcgtgg ccaacgcccc
     1141 cgcaacagcc gacgccccca ggtcggggtg cccttcgacg tgtttctcca gccgggccgc
     1201 ctgggcccgc aacgccacct gcgacttcgc cgacaacacc cacgacacaa ccccgcccgg
     1261 ctcctcaacc cccgagcctt ccgacagcgc cccctccaca gcgggcggag cctccagcac
     1321 cacatgcgca ttcgtcccac tgatcccgaa cgaagagacc gcagcccgcc gcggacgccc
     1381 cgtctgcggc cacgcggtcg actcggtcaa cagccgcacc ccacccaccg accagtccac
     1441 atgcggcgtc ggctcatcca catgcaacgt gcgcggcagc acaccgtgcc gcatcgcctc
     1501 caccatcttg atcacacccg ccacacccgc agcagcctgc gtatgaccga tgttcgactt
     1561 caccgacccc aaccacaacg gccgatcgtc gggccgatcc tgcccatacg tcgccaacag
     1621 cgcctgcgcc tcgatcggat cacccaacct cgtgcccgta ccgtgcgcct ccaccacatc
     1681 aacaccactg gcgggcagat cagcattggc caacgccgca cgaatcaccc gctcctgcga
     1741 cggaccgttc ggagccgtca gaccgttgct cgcgccgtcc tggttgactg cgctgccgcg
     1801 gatgacggcc agtaccgggt ggccgttgcg ctgcgcgtcc gacagtcgct caagtaccag
     1861 cagtccgacg ccctcgcccc aggcggtgcc gtccgccgag gcggcgaagg cgcggcagcg
     1921 cccgtccggg gacagcccgc gctggcggct gaactccacg aagacgccgg ggtgggacat
     1981 gatcgtcgcg ccgcccgcca aggcgagacg ggtctcgccg ttgcgcagtg cctgggcggc
     2041 caggtgcatg gcggtcagcg acgacgagca cgccgtgtcg atcgtgaccg ccgggccttc
     2101 cagccccagg gtgtaggcga gccggcccga ggccacactg gtcagcaggc cggtgagcag
     2161 gtagccgtcc gctgctgccg ggccgccgtc gcgcagcgac gcgtactccg cgccggcggc
     2221 gccgatgaag actccggcgt cggtgccgtg cagctcgccg gggacgaggg aagcgtgctc
     2281 cagggcttcc caggccgtct ccagcaacag ccgctgctgc gggtccatcg ccaacgcctc
     2341 gcgcggactg atgccgaaga actccgcgtc gaaccgggcg gctccctgta cgaagtttcc
     2401 ccgcgccgag tacgtcttgc cgtgcgcctc ggggtcgggg tcgtacagat cgtcgggcca
     2461 gcctcgatcg tccgggaagc ccgagacgct ctcccggctc tggctcacga gctcccacag
     2521 tgcctccggt gagtccgcgt cgcccgggaa gcggcaggcc atccccacga tggcgatcgg
     2581 ctcgcggctc tgcgactcgt actcgtcgag gcggcgccgt gcctggtgga ggtcggccgt
     2641 gacgcgcttg aggtagtcgc gcagcttgtc ctcgttcatc gtgtgtcaac ctcggagttg
     2701 ttgtcggtct gccgcgcagc gacggttcga ctcactccgc ggccgcagcg tccggacgaa
     2761 cgggtacggg ctcaccgccc ggggagggcg cgagatcacc cgaaaggtga tcattgctgt
     2821 ctgcatcctc cgcagagggg ctgaagtggc tctagtttgt gacttgggtg gcggctgtcc
     2881 gggggccgac gacggctacc actccaccgg gagccggtcg agcccgtagg tgttgaatgc
     2941 ctcgcgggtg gtgatctccg cgtcgtctga cgccaggcgc agcgccggga agcgttgcca
     3001 caccgcaccg atggcgatct tcatctcgga cctggcgagg ttgtgtccga tgcactggtg
     3061 gatgccgtgg ccgaaggtca ggtgacttcc ggaagccggg gcctgccccg acgcctgcgg
     3121 gcttccggaa gccggggcgt gcctcgacgc ctgcgggctt ccggaagccg gggcgtgcct
     3181 cgacgcctgc ggggtttcgg ccgtgtcgcc gacggccttg aagaggtccg gttcatcgaa
     3241 ggcccgggcg tcccggttca cggcaggaag ggagatcgtg caggcctcgc ccttccgcac
     3301 ggtgacgccg cccagttcga cgtccgtcag agccacccgg gtgacgaact ggacggccga
     3361 caggcagcgc aggagttcgt tcaccgcctc gtccgtcagc acgggaccgc cgatcagccg
     3421 gtcacggatc tcctcgtgcc gcagcaggta gtacatgctg aggccgatca tctgggcggt
     3481 cgtctcatgg ccggcgatga gcatcatcag ggcgaggccg gtcagctcgg cgtcgtcgag
     3541 ttcgccgtcg ccgatcagct tggtgagcag atcgtcgccg ggggtgtccc gcttgtacgc
     3601 cacgaggttc tgcatgagct cgtgggtcgc cttcactgag gcgcccacgt cttcggccgg
     3661 gctcctcgga tccatggaga cggcccggag ccgctgcaat tcctcgttga tctccggagt
     3721 ggaaccgagc agctcggaga tcaccgcgac cgggatcggc agggcgaagg cgcgcatcag
     3781 gtcggtgggc gcgcccgtct tctccatggt gttcaggtgc tcgcgcgtcg tccgctcgat
     3841 cgcgggttcg agttgccgta tgcggcggac ggtgaagtac tggttgagag gcttccggta
     3901 gcgggtgtgc tcgggcgggt ccatgccgat gaacgccccg ggcggggcgg gcgtcggtgt
     3961 gagcatcgtc gggatcggtg agtgccgcag gtcgtgacgt gcgctgaagt cctggctggc
     4021 cagtatctga cgtgccagaa agtggctcgt caccagccag cccatgtggc cgtccgggta
     4081 ggacatgcgg gcgaggggcc gggtcgcgct cagctcggtc agctccgcgg gcgggctgaa
     4141 cgggcagccg cgagccgtcg gaagtccctc gacggcgtcc ggttccactg tcatgaaggc
     4201 tcctgatgtc gtggatcggc tccggtcaga gctcgttgtc gatgaaggcg aagatctcgt
     4261 cgtccgtgga ggacgccatc tgctggtaga cgtcgtcctc ttcaccgctc gcctgcggct
     4321 cggcgcctga ggtgagtttg cggagccact ccttgaggtg ggcggcgatc tcggtgcgcg
     4381 cctccgggcc gggctcctcg gacagcacgc tgctctcgag ccgctggatg tccgagagca
     4441 cgtggtgcag gaagtcgccc tgttcgggcg ccagttgttt catgaggtgg tcggcgacgg
     4501 cctcaggagt ggggtggtcg tagatcagcg acgccggaag ccgcagctcg acggctgtgg
     4561 cgagccggtt gcgcagttcg acggcggtca gcgagtcgaa gccggcctcc ttcagcggac
     4621 ggttgtgacc gaaggcgtcg agctcgctgt gaccgagcac ggcggccgcc tcggtgagga
     4681 cgagccgcgt cagctgctcg cgctgctcgt cctccgtcag gcccgcaagg tcctcacgcc
     4741 aggtcccgcc acgcttcgac gcgggaacgg cgactcccgg gctcgtcctg cggcccacgc
     4801 cccggcccgg gccgcgtacg tcgaaaaggt ctcgcagtac gggcagtcgc gttgcctgcg
     4861 tccctgagcc gtccggcgtc gatggcggtg gcacgaagcg ggcgggcacc gacgccaccc
     4921 gtcccgtggc gagcgcagag tccagcagcg cgagtgcctc ctggtgggac atggcccgga
     4981 taccggtgcc cctcatgcgg gagagggcgg agccctccag gtgcgccgtc ataccgccgg
     5041 cttctcccca cagtccccag gccagtgaca ccgcgggcag acctcgctcg cggcggtggt
     5101 gggccagggc gtcgaggaac gtgttggcgg cggcgtagtt cgcctggccg ggactgccga
     5161 ggactccggc cacggacgag aacagcacga acgcggagag gtccaggtgc tcggtggcac
     5221 ggtgcagatg ccaggctccg tcggccttcg gacgcagcac cgcgtggaga gcgtccgggg
     5281 tcagggcggc caccgtggca tcgtcgagga cgccggcggt gtggaagacc gcggtgaggg
     5341 gatgagccgc cggtatcccc tccagcaggc cggccaccgc tgacgggacc gccacgtcac
     5401 aggaggcgac ggtcacctcg gcgcccagag cggcgagctc ggcctcggcc tcggcggctc
     5461 cctcggcgtc acgcccccgg cggctggtga gcagcaggtg ccgtacgccg tgtcgtgcca
     5521 ccagatgacg cgccagagcc ctgcccagcg cgccggtgcc gccggtgatc aggaccgtgc
     5581 cgctcaggga cagcggggcc ggcacggtga gtacgacctt gcccacgtgc ttcgcctcgc
     5641 gcaggcaccg gaaggcctcg ccggcctggc ggacgtccca ggtggtgacc ggcggcggcc
     5701 gcaggacacc gctctcgaag agggcgatca gctcgtcgag catcgcgccg atccggtcgg
     5761 gaccggcgtc ggtcatgtcg aaggcccggt agcggacgcc tggactggct gcggcgatct
     5821 cgtcggcaga cctgatgtcg gtcttgccca tctccaggaa ccggccgccg cgcggcagca
     5881 gccgcaacga cgcgtcgacg aactcgtgcg cgagggagtt gaggaccacg tcgacgcccg
     5941 caccgtccgt cgcctgcgcg aacacctcct ggaaggccag gctgcgcgag tcaccgatgt
     6001 gccggtcgtc caacccctgg gagcgcagga agtcccactt gccacgactg gccgtcccgt
     6061 acacctccag cccccaatga cgggccagtt ggagagccgc cgtgccgacg ccgcccgccg
     6121 ccgcgtggac gagcagcctc tcccccgccc gcacaccggc cagatccgcc agcccgtagt
     6181 acgcggtcag gaacaccacc ggtacggccg cggcctgcgc gaacgaccag cccgccggta
     6241 cgcgcctgac caggcggtgg tcggccacgg cgacagggcc catcgcaccg ggtatcaggc
     6301 ccatcacccg gtcaccgacc atcagcccgg tcaccccggc gcccacctcg gtgacgacac
     6361 cggcgccctc tcccccgatg atctcctccc cggggtacat gccgagtgcg atgagcacgt
     6421 cccggtagtt cacgcccgcc gcccgtacgg cgatacggac ctgcccctcg cccagcggtt
     6481 tctccgcgtc atgaaaggcc agcagggcaa gctcgtccaa cgtgccaggc gtcctgacgt
     6541 cgagccgcca cgcgtcctcg tccgccggcg ggctcaacga agggcaggcg ccggaccgta
     6601 cgagacgcgg cacgtacagg tcgcccttcc gcaccgcgac ctggtcttcc tccccgcctg
     6661 cgagcactgg cgccacgtcg ccgccgagca ctgctgccac gtcgaccggt cgccgccggg
     6721 gcgcggcgct gtcgtccacg tccacgccgg gctcgccgtt cacggccatg tccacgttcg
     6781 ggtccacggc cgcgctcggg tccacggccg cgctcgggcc catgtccgcg tacaggtcca
     6841 tgtccgcgtt caggtccacg tccagcagcg cgaaacggcc ggggtgctcg cgttgagccg
     6901 agcgcagcaa cccccacagc gaagccgctg cgggatccac ggctgcgccg ttgttctcga
     6961 cactcacggc gttctccgtc accacgacca gccggcagtc cacaagacgc tcgtccgaca
     7021 gccatgtctg caccaggtcg agtgcctcgc ccgtcacggc gtgggccgcg ctcaccgggt
     7081 cggcggcggc aggggccgag cgcctatccc tccggccgac ggcaccggcg tcgtcgtcac
     7141 tgtgcggcac cggcggaaag acggcgaaca cctcgcgggg aaccggtgcg ccctcggcaa
     7201 ggcggtccag gaacgcgcgg acgtcggagt ggacgtcgaa gcggacgtcc gagtgggctg
     7261 cggagtggac gatgtccgtc gggaggctac ggggttcggc ggcggctgcc gctggtgccg
     7321 ccgctgcctc ggggagtacg cccagcaggg tgacggtgcg ggacggttcg cccacgacgc
     7381 gctcagctgc ggagacgggg gccagcaacg gcgtccacgc aaggtggggt ggttcgtcgt
     7441 gacgcgctcg caaccggtca gccggcttca catccgcggg gcgcacggtg aggccgccga
     7501 cggtgaccac gggttccccg tcgagggtcg atacggtcag cgcggccgtg tcctcggcgg
     7561 tggccgacaa acgcacgcgc agctcggtgg cgccggtggc gtgcaccgtg acatcgcgcc
     7621 atgagtaggg gagacggaga acagcctcct cgcccgcctg acgagtgagg agggcgaggg
     7681 ggtggagtgc ggcgtcgagg agggcggggt ggatgccgta cccgccgggc tccagggtct
     7741 ggggcagtgt gacgtcggcg cagatgtcct gaccgtgtcg ccaggcccgc tccagcccct
     7801 ggaaggcagg cccgtaatcc atccccgcct ccgccagctc cagcgacagc tcctgcacat
     7861 cgacgggctg cgcgtcggca ggaagccgca ccggggccgg tggagtgtcc gcctccgagg
     7921 cggtggtcaa gaccgcctcg gcgtgacaca cccacggccg accctcctct cccgagtccg
     7981 agtcggagtc cgtgccggtg tccgcctctc gtgcgtgcac caggacctgg cgacgacccg
     8041 tctcatccgg cggctccacc accatctgca accgcagcgc cccgtccccc tccaagacga
     8101 ccggcgtgtg caacgtcaac tcctccacac acgccatccc cgaaacccgt gcggcatgcg
     8161 tgaccaactc gacgaaggcc gtaccaggaa gcaccacgac atcccccacg gcgtgatccg
     8221 caagccaccg gtgactccca ggacccagcc gcgtggtgaa cacatgcccc ccactgggca
     8281 gatcgacatg cgcagacaac aacggatgcc ccggcgcatt caaccccgac cccaccacat
     8341 ccaccgaccc accaaccggc tccaaccaaa agctccgacg aacaaacgcg taggtgggca
     8401 acggaacagc aggtcggatg gcgttcgggt gggggtggtg ccaggtcagc gggtgggtgg
     8461 tggtgtgggc gtgggcgagg gtggtggtga gggcgtgggt gtcgtggtgg tcggggtgga
     8521 gggtggtgag gacggtgggg gt
//
