LOCUS       NZ_QOIM01000041        21080 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces reniochalinae strain LHW50302
            NODE_6_length_351937_cov_16.9904_ID_11, whole genome shotgun
            sequence.
ACCESSION   NZ_QOIM01000041
VERSION     NZ_QOIM01000041.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces reniochalinae
  ORGANISM  Streptomyces reniochalinae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 351937)
  AUTHORS   Li,L.
  TITLE     Streptomyces reniochalinae sp. nov. and Streptomyces diacarnus sp.
            nov. from marine sponges
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 351937)
  AUTHORS   Li,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUN-2018) Department of Pharmacy, Ren Ji Hospital
            School of Medicine, Shanghai Jiao Tong University, Pujian, Pudong,
            Shanghai 200127, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-FEB-2016
            Assembly Method                   :: A5-misseq v. MARCH-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003323735.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 01:54:27
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,751
            CDSs (total)                      :: 6,669
            Genes (coding)                    :: 6,475
            CDSs (with protein)               :: 6,475
            Genes (RNA)                       :: 82
            rRNAs                             :: 6, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 4, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 66 of 194
            Pseudo Genes (incomplete)         :: 154 of 194
            Pseudo Genes (internal stop)      :: 16 of 194
            Pseudo Genes (multiple problems)  :: 41 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:03:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 90295
            Orig. end                         :: 111375
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QOIM01000041.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21080
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21080
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21080
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11080](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11080
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            567..902
                     /locus_tag="DQ392_RS24250"
                     /old_locus_tag="DQ392_24230"
     CDS             567..902
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964185.1"
                     /locus_tag="DQ392_RS24250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24230"
                     /product="Asp23/Gls24 family envelope stress response
                     protein"
                     /protein_id="WP_114017828.1"
                     /transl_table=11
                     /translation="MTGDEREQRVAAAAAAALQVQGVAFLKPGLAGRLRASASALARTG
                     RGPDRRRTDPAAGVRVRQGTPWTAEVHIVLQRGHRALDVTRAVRSAVADSFGETPVRVT
                     VTVSGMV"
     gene            1112..1540
                     /locus_tag="DQ392_RS24255"
                     /old_locus_tag="DQ392_24235"
     CDS             1112..1540
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470804.1"
                     /locus_tag="DQ392_RS24255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24235"
                     /product="ATP-binding protein"
                     /protein_id="WP_114017829.1"
                     /transl_table=11
                     /translation="MDQATALQDEEERNLPAAMAQTAYVSSSFEARQLTRDFLTTLVPR
                     PSQETTETFLLVVSELVTNALRYGNGVTDFQLGATCDTLTIDVGDSNSALPRERTPGSL
                     EGGENGGFGWPIIRHLAHDITIRLRRNNGKIIHAGIPM"
     gene            1658..2173
                     /locus_tag="DQ392_RS24260"
                     /old_locus_tag="DQ392_24240"
     CDS             1658..2173
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470805.1"
                     /locus_tag="DQ392_RS24260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24240"
                     /product="VOC family protein"
                     /protein_id="WP_114017830.1"
                     /transl_table=11
                     /translation="MHGVRGIDHVGVTVPDIEAATEFFVRALGAEKLYDTLPREEGPKG
                     GEETVRRLGVPPGTEQVAMRMLRLPRGPGLELFEFRGPRRRGAVVPSDLGWQHLACYVE
                     DLPAACEAVRGAGGTVLGEPRPLPGPEAGPRNRFLYCRTPWGSTLELLTYPDPMPYEDT
                     TELRRWRP"
     gene            complement(2982..4004)
                     /gene="nrfD"
                     /locus_tag="DQ392_RS24265"
                     /old_locus_tag="DQ392_24245"
     CDS             complement(2982..4004)
                     /codon_start=1
                     /gene="nrfD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537624.1"
                     /locus_tag="DQ392_RS24265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24245"
                     /product="NrfD/PsrC family molybdoenzyme membrane anchor
                     subunit"
                     /protein_id="WP_114017831.1"
                     /transl_table=11
                     /translation="MTTAPLNGGKRRRKRRGEQTVVPDAEFTSYYGKPILNTPEWKPLN
                     IGGYFFLGGLAGAGSLLAAGATATQRPVMARSMKITSTVAIAGSAAALIHDLGKPARFA
                     NMLRVLKPTSPMSVGSWLLAAYGPLAGAAAVSDLTGVLPRAGHAATAGAALLGPAVATY
                     TAVLASDTAAPAWHDGYRELPFVFAGSATAAAAGTALLTAPLRENRPARHAALFGAGLE
                     AAATHRLESRLGIVAETYRKGLAGRLMRSAKVLTAAGALAGAAAGGRNRGLAAMSGAAL
                     LAGSVCTRLGVFHAGRAALADPKYTVVPQRERLRAREAAQATMATPSTDHNHAPPTEPT
                     "
     gene            complement(4001..4912)
                     /locus_tag="DQ392_RS24270"
                     /old_locus_tag="DQ392_24250"
     CDS             complement(4001..4912)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014057198.1"
                     /locus_tag="DQ392_RS24270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24250"
                     /product="4Fe-4S dicluster domain-containing protein"
                     /protein_id="WP_114018017.1"
                     /transl_table=11
                     /translation="MGFFTDTSVCIGCKACEVACKEWNAIPEDGMELTGMSYDNTQGLG
                     ASTWRHVAFIEQSKPVVPKEHPGQHQHQGDGAQSPQGEGPQDDADVFALAAQGSGSSEL
                     RWLMSSDVCKHCTHAACLDVCPTGSLFRTEFGTVVVQEDICNGCGYCVPACPYGVIEQR
                     PDDGRAFKCTLCYDRLGEGQTPACAKACPTESIQYGPLDELRERAADRVEELHRAGVPD
                     ARLYGHDPDDGVGGDGAFFLLLDEPEVYGLPPDPVVTTRDLPAMWKQAGAAALTLLGGL
                     AAAFATSGKPKTTRGSFTRRRP"
     gene            complement(5197..8460)
                     /gene="fdh"
                     /locus_tag="DQ392_RS24275"
                     /old_locus_tag="DQ392_24255"
     CDS             complement(5197..8460)
                     /EC_number="1.17.-.-"
                     /codon_start=1
                     /gene="fdh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470808.1"
                     /locus_tag="DQ392_RS24275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24255"
                     /product="formate dehydrogenase"
                     /protein_id="WP_114017832.1"
                     /transl_table=11
                     /translation="MGVRTWIKDWPVYRQAMGGDPTGRGAAASSAYTRSLRPRTHSADR
                     VVKSICPYCAVGCGQDVYVKNEQVVQIEGDPDSPVSRGRLCPKGAATLQLTTGDARRHE
                     VLYRRPHGTDWERLDLETAMDMVADRVIRTRRQGWEHERDGVRVNRTMGLAALGGAALD
                     NEENYLIKKLLTALGVVQIENQARVCHSSTVAGLGTSFGRGGATTFLQDLQHADCIVIE
                     GSNFAEAHPVGFQWVMEAKARGATIIHVDPRFTRTSALADLHVPIRAGTDIAFLGGIIN
                     YVLSHEADFREYVLDYTNASTLVGEDFRDTEDLDGVFSGLNQETGHYDTASWQYEGDVV
                     QAASGERDALYEERTRQGRSVAAAGGSESHGSGGAPVSGNRTHDRTLRHPRCVFQILKR
                     HYARYTPEMVEETCGIPPETFLGVCRALVDNSGPDRTSAFAYAVGWTQHTVGAQYIRAA
                     CVLQLLLGNIGRPGGGIQALRGHASIQGSSDIPTLFNLLPGYIPMPHAHKAEDLDTFTG
                     AMRTDKGYWGDMRNYVVSLLKAYWGEAATAENDYCFDHLPRLTGSHSTYDTVLEQLAGR
                     CKGYFLMGENPAVGSANAKMQRMGMANLDWLVVRDFSLIESATWWKDGPETETGELKTE
                     ENATEVFFFPAASHTEKAGSFTNTNRMLQWHYPAKEPDGEARSDLWFMYHLGRRIREKL
                     RGSTDPIDRPVLDLTWDYPVDGPLEEPVADAVLAEINGRHADGSPLSRYQELRDDGSTS
                     CGCWIYCGVYKDGVNQAARKKPHTQQDWIAAEWAWSWPSNRRILYNRASADPEGAPWSP
                     GKALVWWDAERSAWSGHDVPDFPADRPPSHRPAPDATGPDALSGIDPFIMQGDGKGWLY
                     APAGLMDGPLPTHYEPQDSPVHNPLHPDQQRSPVRETHSHPANAYHPSGHEAGTGVFPY
                     VVTTYRLTEHFTAGGMSRWSPYLSELQPEFFCEVSPQLAAERGLEHTGWATVVTARGAV
                     EARVLVTERMRPLRVGGHAVHQIGLPYHWGRNGYTRGDAANELTSIALDPNVHIQEVKA
                     LTADIRPGRRPRGPELLTLLADYRERAGITEHTGTEVRG"
     gene            complement(8512..9633)
                     /locus_tag="DQ392_RS24280"
                     /old_locus_tag="DQ392_24260"
     CDS             complement(8512..9633)
                     /GO_function="GO:0045027 - DNA end binding [Evidence IEA]"
                     /GO_process="GO:0006303 - double-strand break repair via
                     nonhomologous end joining [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389547.1"
                     /locus_tag="DQ392_RS24280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24260"
                     /product="Ku protein"
                     /protein_id="WP_114017833.1"
                     /transl_table=11
                     /translation="MARPVWSGVITFGLVTVPVRMYAATEDHTTHFHQLQRGTNDRVRN
                     KRVNERTGKSVGYDDIVKGYEIADGQYVTVEREELEEIAPGKSQVIDVSGFVEADEVDP
                     VYYVRSYYLSPGDEKYRKPYELLRAALESSAKTGIATFVMHGKEYLVALRAGENVLALH
                     TLHWADEVRDPEEELSELPGRQRSDSKELKTARQLIDSMSTTFHPEDYSDRYEARVRAL
                     VQAKAEGEELTPEEGPPEATNVVDLSEALNRSIERARSGKKGGDGGRKTGGGRQKSTAR
                     DRTHPAKRRQSTSRSGTGAWKSRAGTSKSRTGAPKGRTGASKNTSPLRDLGKDELYRRA
                     GDQGVKGRSKMTREQLLEALEALAGSGSSGKAA"
     misc_feature    complement(9739..9750)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            10001..11080
                     /locus_tag="DQ392_RS24285"
                     /old_locus_tag="DQ392_24265"
     CDS             10001..11080
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019354042.1"
                     /locus_tag="DQ392_RS24285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24265"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_114017834.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5e-36, bitscore:
                     118.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTEELSDTHGLPAAPSLLSTAHERIEPLLREAVGALQPELRRVC
                     GYHFGWSQPDGSPTYGVTPEPPLRAALTLCAAGASETGRDGSATDPTAAALPGAAAVEL
                     VHNWASLHDDVMDGEALRHGRSAVWAVYGTGWAVLAGDALLGAATRRVLPTGADPEAEG
                     AVLRLLTRTTSRLVSGRSAELALRRRAPEGISVEEYAVVAGARRSSLLECALAGGALLA
                     GADERVVEALTRAGHHLGVAAQVARDIEDLWSGTALSGRPVMSGLREGGPSLPLIAALR
                     AGNPAARTLAQSLGGGPACPPPPDELAALIDHAGGRAAADEISAWQLTEALTQLDKAAL
                     PPATHAALTALFRHTVARG"
     gene            11233..12666
                     /locus_tag="DQ392_RS24290"
                     /old_locus_tag="DQ392_24270"
     CDS             11233..12666
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0045227 - capsule polysaccharide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470811.1"
                     /locus_tag="DQ392_RS24290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24270"
                     /product="CapA family protein"
                     /protein_id="WP_245981873.1"
                     /transl_table=11
                     /translation="MRTHVPPGRGRRSGRRPGRRRAPRDARLASPIRLSSPIRPFLPTD
                     LVARARLFRRVRLLPRIHPVGRVRPTRGRLRARGLLAAVAVTALLGGVAGCGTAADGVR
                     SGSAGTGARAERGEGQQSVHERGQGDAQGFSLVATGDLLVHDSIIRQARADAGGPGYDF
                     GRMIDAAKPMVRKADLAICHMETVYGPDGGPFSGYPLFKTPPQLARSVKNVGYDSCSTG
                     SNHTLDDSSDGVHRTLEAMDSAGLQHVGSARSARERGRPAVLRAGGAKVAQLAYTYGTN
                     GISVPENKPWLVNLIEPQRIIRDARAARRAGADVVVVSMHWGTEWQQKPDQLQRSMAKT
                     LTASRSHGRRDVDLILGTHAHVPQAYEKVNGTWVVYGMGDQIAGKMNDPRGSMGTAARF
                     HFVPPGRTSDRGHKGAWTIDKASFTPFLMRSSPRYTLVNLASGSSRSAGDPAQDKAYET
                     IREAVFSRGAKKDGLRMVP"
     misc_feature    11236..11249
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.43"
                     /tool="antismash"
     gene            complement(12791..14254)
                     /locus_tag="DQ392_RS24295"
                     /old_locus_tag="DQ392_24275"
     CDS             complement(12791..14254)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019354046.1"
                     /locus_tag="DQ392_RS24295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24275"
                     /product="APC family permease"
                     /protein_id="WP_245981876.1"
                     /transl_table=11
                     /translation="MTDTHEDTSRPRLTRSIGVVGGTLLTLSCLTPASSLFVIVPDSFG
                     TLGTGTALTLAIAALLCVGVAFTYSELGTLVPSSGGEYAMVGTLMGRLAGWLVFVLSLI
                     VVMIVPPIIALGTADYLAPLVQLDPRVAAAAVMLLSTAMGLLDLRANAWITGVFLALEV
                     VGAAIVAFLGFTHAQRPASVLLHPVMDSGQGHTSPVTAGLIVTGLATALFILQGFTTAV
                     YLAEEMENPRRTVSRTVLWTLSIGFAIVIVPVVALTLGAPDLHALAGGDIAGMVQQWSN
                     SAVGTFISLCIALAIINAAIVMVIQNSRVVFASARDAAWPGPVNRALSRLGTRFASPWV
                     ATLVVGVPGAVLCFVNLDVLNEVTGVAVAGLYVFVALGALAARREAFKHRAAWRMPLWP
                     VLPALLMAALIWVLYQQSAESLAVTGGIVAAAALYWACYLRPRRATHWVISVPEEEHAG
                     AGSGDATGGSPQCSHNPPSAGHDESLQNV"
     misc_feature    complement(14378..14391)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.82"
                     /tool="antismash"
     misc_feature    14439..14454
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            complement(14549..16078)
                     /locus_tag="DQ392_RS24300"
                     /old_locus_tag="DQ392_24280"
     CDS             complement(14549..16078)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016908284.1"
                     /locus_tag="DQ392_RS24300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24280"
                     /product="SLC13 family permease"
                     /protein_id="WP_114017835.1"
                     /transl_table=11
                     /translation="MDNPAPLVHTAIAIAAVVVLILKAKVNPALALVLGAVYLGLAGGL
                     GAERTLKTVNKGFGDLMAEVGLLIVLGVLLGTLLSALGAIDKLVTLLLRTLGPKRLPYS
                     FAITMGTVLQSIFADVLLVMTAPLARSLGTRIGPGGLARMAAAMALGVEVGIALSVPGI
                     GALALAGLLDIPLGIMLLYGFPLAAVTILLTLLLFSALVKRGFWNPDRDESAVAEGEAV
                     VEGGAAVEGGAGFHDGAVAHDGAAARGDATAHGGAGMSGDAAVGEGGAGHAGAGVGDAV
                     AADGDAGTARGDGTAPPLGLSLTPLLLALVLIATGAFAQVAGWDSPVVGFLGDPVVGLL
                     TGLILACLVARRRLPAGAVGEAFGQGFRTSGQILVLTGVGGSLAAVVEAVGLGDLIKDS
                     FSAGTWAPLALVWLIAAVLHMAIGSVTTSAITAAGILAPVAPSLDVQPVLIALAAGAGS
                     LFAIHATSNTFWLLQTLLGQTTRGTLKTVTLTVSGASVIALGLIQTVSLVM"
     gene            complement(16237..17109)
                     /locus_tag="DQ392_RS24305"
                     /old_locus_tag="DQ392_24285"
     CDS             complement(16237..17109)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019359722.1"
                     /locus_tag="DQ392_RS24305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24285"
                     /product="glycoside hydrolase family 16 protein"
                     /protein_id="WP_114017836.1"
                     /transl_table=11
                     /translation="MRLPWRLRTAVCGATLLCCTTAALLPATGSAGAADSGRPGSGAQA
                     VVFSDDFDGPAGSPADSGKWQTETGDNVDNHERQYYTPGTDNAALDGNGNLVVTARKEN
                     PGNYQCWYGTCEYTSARLNTAGKFTQTHGHVEARIKVPRGQGMWPAFWMLGDDIGSAGW
                     PACGEIDVMENVGFEPNTVHGTLHGPGYSGSGGIGAAYSLPDGAAFADDFHVFAIDWSP
                     GAISWSVDGNVYQTRTPADTGANPWVFDKPFFLILNLAVGGYWPGDPDGSTTFPQQMTV
                     DYVRVTAGD"
     misc_feature    complement(17258..17273)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.85"
                     /tool="antismash"
     gene            complement(17378..18373)
                     /gene="meaB"
                     /locus_tag="DQ392_RS24310"
                     /old_locus_tag="DQ392_24290"
     CDS             complement(17378..18373)
                     /EC_number="3.6.5.-"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="meaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470816.1"
                     /locus_tag="DQ392_RS24310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24290"
                     /product="methylmalonyl Co-A mutase-associated GTPase MeaB"
                     /protein_id="WP_114017837.1"
                     /transl_table=11
                     /translation="MPRTIDPDDYAKGVLAGSRASIARAITLVESRRADHRELAQQLLT
                     ALLPHAGGSRRVGISGVPGVGKSTFIDALGTLLTERGHRVAVLAVDPSSTRTGGSILGD
                     KTRMERLAVNPDAFVRPSPTAGTLGGVAKATRETMIVMEAAGYDAVLVETVGVGQSEAT
                     VAQMVDSFLLLTLARTGDQLQGIKKGVLELADVLAVNKADGPHERDARSAARELAGALR
                     LMRSADASWTPPVLTCSGREGTGLDEVWERVERHREVQESTGELAAKRRDQQVEWVWSM
                     VRDDLLGRLEQHPGVRRLAPLLEERVREGSLTATRAAQRIVETFGGRAAD"
     gene            complement(18378..20711)
                     /gene="scpA"
                     /locus_tag="DQ392_RS24315"
                     /old_locus_tag="DQ392_24295"
     CDS             complement(18378..20711)
                     /EC_number="5.4.99.2"
                     /GO_function="GO:0004494 - methylmalonyl-CoA mutase
                     activity [Evidence IEA]"
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470817.1"
                     /locus_tag="DQ392_RS24315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_24295"
                     /product="methylmalonyl-CoA mutase"
                     /protein_id="WP_245981879.1"
                     /transl_table=11
                     /translation="MSRQTTGAEDSAAIPDFTTVGLESDPGAERGAEGGRGSDGERWRE
                     TVKERTGRSVEDLAWHTPEGIAVKPLYTEEDLHGLDFLGTYPGIAPYLRGPYPTMYVNQ
                     PWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDHPRVTGDVGMAGV
                     AIDSLYDMRQLFDGIPLDRMTVSMTMNGAVLPVLALYIVAAEEQGVPPEKLAGTIQNDI
                     LKEFMVRNTYIYPPQPSMRIISDIFAYTSQKMPRYNSISISGYHIQEAGATADLELAYT
                     LADGVEYLRAGLDAGMDVDAFAPRLSFFWAIGMNFFMEVAKLRAARLLWAKLVNGFEPK
                     NPKSLSLRTHSQTSGWSLTAQDVFNNVTRTCVEAMAATQGHTQSLHTNALDEALALPTD
                     FSARIARNTQLLLQQESGTCRVIDPWGGSAYVERLTHDLAARAWQHIEEVEAAGGMAKA
                     IDAGIPKLRVEEAAARTQARIDSGRQPVIGVNKYRAASDEQIDVLKVDNSSVRAQQVAK
                     LRRLREERDEGACRAALEALTRAAGAASGPGLENNLLALAVDAARAMATVGEISEALEK
                     VYGRHSGQIRTISGVYREEAGVSSSLARTRELVDAFEEAEGRRPRLLVAKMGQDGHDRG
                     QKVIATAFADLGFDVDVGPLFQTPAEVARQAVEADAHIVGVSSLAAGHLTLVPALREEL
                     AAAGREDIMIVVGGVIPPADVEPLHEAGATAVFPPGTVIPEAAYDLLRELAASLGHDEL
                     AEPAESAEPSEGATGSEGPAEGEG"
ORIGIN
        1 tgcggagctc ggtctgctcg gtgacacggt gcgggacgtg ctcgcctcgg agccggacga
       61 cagagacggg caggggtggg acaccacggc gctgaccgcg cgggtcatgg acgtggtgcg
      121 gctggagctg cgccccgggc gccccctccc gctgggggag acctccgagg acctgtggat
      181 catggaggcg gccgcggcga agacggtgcg ggctgcggcc gagtccttgg caggggtaca
      241 cgcgggagcc tgccgcatcg gcccgccacc ggagcagttc gtccccgccc ggccgacgga
      301 ggagcggcgc cgcccgaccc acgtggagct ggaggtggcc gtctccgatc tcgctccgtt
      361 gtgggaggtg gccgacgggg tgcgtgagcg ggtgcgcatg gcggtggacc acgagctggg
      421 gatggatgtc gccgccatcg acatccggat caccgacatc tacgccgacg aggacgacga
      481 cgaggagata ggcatgccgg gccggccggg tcacgggagg agtgggtcgg ggcgggcccc
      541 ggccggtggc tgggaggtga ctctcgatga ccggtgacga acgggagcag cgcgtcgcgg
      601 ccgcggcggc agccgctctc caggtgcagg gtgtcgcttt tctgaaacct ggcctggcag
      661 gcaggctgcg ggcctccgcc tcggctctcg ccagaacggg gaggggcccg gaccgtcgcc
      721 ggaccgaccc ggcggcgggt gtccgggtgc gccagggcac gccgtggacg gcggaggtgc
      781 acattgtgct gcaacgtggt caccgggcgt tggacgtcac gcgggcggtg cggtccgcgg
      841 tggcggattc cttcggcgaa accccggtgc gtgtcaccgt cacggtctcc ggaatggtct
      901 gacctctctc agccccgcag gggccgatgc atgaagacgg aggcgccggg taactgaccc
      961 tgcatccgtt cgagcgttca cgcggggcac cgttcgacgg gcggcgtggt agcacgcttt
     1021 gcgtactacc acgccgagga gaggaaagac ccccacattc gcggggaccg gccgtttcca
     1081 cggtgagcgt ccgcgaagac gggagacaga catggatcag gcaacagccc ttcaggacga
     1141 ggaggagcga aatcttccgg cggccatggc acagaccgct tatgtgagca gcagtttcga
     1201 ggcccgtcag ctcacccggg atttcctcac cactctcgtt ccgcggccct cgcaggagac
     1261 cacggagaca ttcctgctgg tggtatccga gctggtgacc aacgcactac ggtacgggaa
     1321 cggagtcacg gacttccaat tgggagccac gtgcgacacc ctcacgatcg acgtggggga
     1381 ttccaattcc gcgctcccga gggagcgaac cccggggagc cttgagggcg gggaaaacgg
     1441 agggttcggt tggcccatca tccgccacct ggcccacgac atcaccattc ggctgcgtcg
     1501 taacaatggg aagatcattc acgcgggtat tccgatgtga ggagacgctg agagcctgcg
     1561 gggatcgccc gggggtggcg gcactggcca ccgtgatgtc ctgcgaagcc ggatgcggct
     1621 cggcgaagcg gctacgcggg tgagggtggt acgggaaatg catggtgtac ggggaatcga
     1681 ccacgtcgga gtgaccgttc ccgatatcga ggccgcaacg gaattcttcg ttcgggcgct
     1741 cggggccgag aagctgtatg acacgctgcc gcgggaggaa gggcccaagg gaggcgagga
     1801 gaccgtgcgg cgtctggggg taccaccagg caccgagcag gtggccatgc ggatgctgcg
     1861 gctgccgcgc ggtccgggtc tggagttgtt cgagttccgg ggtccccgcc ggcggggagc
     1921 ggtggttccg agtgatctgg gctggcagca tctggcctgc tacgtcgagg atctgcccgc
     1981 cgcatgtgag gccgtgcgcg gggcgggcgg gaccgtgctg ggcgagcctc gtccgttgcc
     2041 gggcccggag gccggtccgc gcaaccggtt cctctactgc cgcactccgt gggggagcac
     2101 tctggaactg ctgacctacc ccgatcccat gccttacgag gacaccaccg agttgcgtcg
     2161 ctggcgtccg tagagctctc gcgtggcggc gcgcggctgg gctcgtgggg gcacacgcgc
     2221 tctcgcggcg tcgtcatcga tcgctggcgt ccccttctac gaatcggacc ggagcgtgcc
     2281 gacgctcggc acggcgggag ggaaaacttg aggccgaccc gggcaggctg cgcgtcggcc
     2341 tccgccttga cttcggcctg acttggccag tcgcgttttc cggtcgcggg ccggtcagag
     2401 cgggcgtctc gtggttgtcg gccgggcccg agttggcttc tgcgggttgt gggctcggtc
     2461 cggatatgcg gctcgtggtc gtgcggccgg cttcgagttg ggtttctgcg ggttgcgggt
     2521 tgcgggttgc gggttgcggg ttgcgggttg cgggttgcgg gttgccgggt gcgggtcgcg
     2581 ggctcggatc gggtacgcgg ttcgtggtcg tgcggctggt tcgagctggg ctgtgtgggg
     2641 tgtgggcccg gaacggacag gcgactcgcg gccgtgcggc cagtacgggc aggaatctcc
     2701 cggtcgtcgc ccggttcgag ccgggctctg ccgggagtcg gccggagccg ggcacgcggc
     2761 ttctggtcgt cagcctgtac gggacgggcg attcccggct cggtccaggc gcaccaacgc
     2821 tcggcctgtt ggcctgttgg cctgtcggcc tgtcggcctg tcggcctgtg ccggccaggg
     2881 gccaggggtt aggcagccga ccagtcggac agtcgggtgc cggtcggccc ggtcggcccg
     2941 gtcggctggt cgaccgggcc gtggccggtt ggtgatccgg gtcaggtggg ttcggtgggg
     3001 ggtgcgtggt tgtggtccgt cgacggggtg gccatggtgg cctgggcggc ctcgcgggcg
     3061 cggagtcgtt cccgctgcgg taccacggtg tatttcggat cggccagtgc cgcgcggcct
     3121 gcgtggaaga ctcccaggcg ggtgcagacc gatccggcga gcagggccgc cccgctcatc
     3181 gccgccaggc cgcggttgcg gccgcccgcc gcggcgccgg ccagtgcccc ggccgcggtg
     3241 agcaccttcg cggagcgcat cagccgtccc gcgagcccct tgcggtaggt ctcggcgacg
     3301 atgcccagcc gggactccag ccggtgggtc gcggcggcct ccagcccggc gccgaagagg
     3361 gcggcgtgcc gggcgggtcg gttctcccgc aggggcgcgg tcagtagcgc tgtgccggcc
     3421 gcggcggcgg tggccgaccc ggcgaagacg aagggcagtt cgcggtagcc gtcgtgccag
     3481 gcgggcgccg ccgtgtcgga ggccagtacg gccgtgtagg tggcgacggc gggcccgagc
     3541 agtgccgcgc ccgcggtggc ggcgtgcccg gcgcgtggca ggacgcctgt caggtccgag
     3601 acggcggcgg cgccggccag cgggccgtag gcggccagca gccaggagcc gacgctcatg
     3661 ggggaggtcg gtttgaggac gcgcagcatg ttggcgaatc tggcgggttt gccgaggtcg
     3721 tggatgaggg ccgcggcgga gcccgcgatg gccaccgtgg aggtgatctt catggagcgc
     3781 gccatcacgg gccgctgtgt cgccgtggct ccggcggcca gcagcgagcc ggctccggcg
     3841 agtccgccga ggaagaagta gccgccgatg ttgaggggtt tccactcggg ggtgttgagg
     3901 atgggtttgc cgtagtagga ggtgaactcc gcgtcgggga cgaccgtttg ttcgcctcgg
     3961 cgcttgcggc gccgcttgcc gccgttgagc ggggccgtcg tcatggccgc ctccttgtga
     4021 acgagccgcg cgtggtcttc ggtttgccgc ttgtcgcgaa ggcggcggcg agtccgccca
     4081 gcagggtgag tgcggctgcg cctgcctgct tccacatggc gggcaggtca cgggtggtga
     4141 ccaccggatc ggggggcagg ccgtagacct cgggttcgtc gagcagcagg aagaacgcgc
     4201 cgtcgccacc cactccgtcg tccgggtcgt ggccgtagag ccgtgcgtcg ggtacgcccg
     4261 cgcggtgcag ttcctcgacc cggtccgctg ctcgttcgcg cagctcgtcc agcgggccgt
     4321 actggatcga ctcggtgggg cacgccttgg cgcaggcggg cgtctggcct tcgccgagcc
     4381 ggtcgtaaca cagagtgcac ttgaaggcgc ggccgtcgtc ggggcgctgc tcgatgacgc
     4441 cataggggca ggcgggtacg cagtagccgc agccgttgca gatgtcctcc tgcaccacca
     4501 ccgtgccgaa ttcggtgcgg aagagggagc cggtcgggca gacgtcgagg caggcggcgt
     4561 gggtgcagtg cttgcacacg tcggaggaca tcaaccagcg cagctcggag gagccggagc
     4621 cctgggccgc cagcgcgaag acgtcggcgt cgtcctgtgg cccttcgcct tgggggcttt
     4681 gagcgccgtc cccttggtgc tggtgctggc cggggtgctc cttgggcacg accggcttgc
     4741 tctgttcgat gaaggcgacg tgtcgccagg tggaggcgcc gagcccctgg gtgttgtcgt
     4801 agctcatccc ggtcagctcc atgccgtctt ccgggatggc gttccactcc ttgcaggcca
     4861 cctcgcacgc cttgcagccg atgcacacgg aggtgtcggt gaagaagccc atgcgctcga
     4921 cggtggccgt cacctcacgc gtccccgtac cgccggcagc agcggtccct gtgccgtcgg
     4981 ccgcggccac ccccgtgcct ccgccgccgc tggtgcccca gctgcccccg gagccgccat
     5041 ggccgccgcc cccggcggcc tccacgccac ccgcggcggc gcccacgccg cccccggccg
     5101 cttccgcgcc gcccccagcg ggccccgcgc cacccccaac agcccccacg ccatcgcgac
     5161 caccggcgcg accgtcgcgg ccaccgtcgc cgtccgtcat ccccgtacct ccgtcccagt
     5221 gtgctcggtg atgcctgctc gttcgcggta gtccgcgagg agggtcaaaa gttcggggcc
     5281 gcgtgggcgg cggcccggcc tgatgtcggc ggtgagggcc tttacttcct ggatgtggac
     5341 gttcgggtcc agcgcgatgg aggtgagttc gttggcggcg tcgccgcgtg tgtagccgtt
     5401 gcgtccccag tggtagggga gtccgatctg gtgtacggcg tggccgccca cccgcagggg
     5461 gcgcatccgt tcggtgacca ggacgcgtgc ttccacggcg ccgcgggcgg tgaccacggt
     5521 ggcccatccc gtgtgttcga ggccgcgctc ggcggcgagt tggggggaga cctcgcagaa
     5581 gaactcgggc tggagttccg acaggtacgg cgaccatcgg ctcatcccgc ccgcggtgaa
     5641 gtgttcggtc agccggtagg tcgtcaccac gtaggggaag acgccggtgc ccgcctcgtg
     5701 gccgctggga tggtacgcgt tggctgggtg ggagtgggtc tcgcggaccg ggctgcgctg
     5761 ctggtcgggg tggagcgggt tgtggacggg ggagtcctgc ggttcgtagt gggtgggcag
     5821 tgggccgtcc atcagaccgg ccggcgcgta gagccatccc tttccgtcgc cctgcatgat
     5881 gaacgggtcg atgcccgaga gcgcgtcggg gccggtggcg tccggggcgg gccggtggga
     5941 gggcgggcgg tcggcgggga agtcgggaac gtcgtgaccg ctccaggcgg atcgctccgc
     6001 gtcccaccac accagggcct tgcccgggct ccagggggcg ccttcggggt cggcggaggc
     6061 gcggttgtag aggatgcgcc ggttggacgg ccaggaccag gcccactcgg cggcgatcca
     6121 gtcctgttgg gtgtggggct tcttgcgggc ggcctggttg acgccgtcct tgtagacgcc
     6181 gcagtagatc cagcagccgc acgaggtcga gccgtcgtcg cgcagttcct ggtagcggga
     6241 cagcggactg ccgtcggcgt ggcggccgtt gatctcggcg agcaccgcgt cggcgacggg
     6301 ttcctccagc ggtccgtcga ccgggtagtc ccaggtcagg tcgagtaccg gccggtcgat
     6361 cgggtcggtg gagccgcgca gcttctcgcg gatgcgccgg cccaggtggt acatgaacca
     6421 caggtcgctg cgggcttcgc cgtccggttc cttggccggg tagtgccatt ggagcatccg
     6481 gttggtgttg gtgaaggagc cggccttctc ggtgtgcgag gcggcgggga agaagaagac
     6541 ctcggtggcg ttctcctccg ttttcagctc gccggtctcc gtctccgggc cgtccttcca
     6601 ccaggtggcc gactcgatga gggagaagtc gcgcacgacg agccagtcga ggttggccat
     6661 gcccatccgc tgcatcttcg cgttcgcgga gccgaccgcc gggttctcgc ccatcaggaa
     6721 gtagcccttg caccgtccgg cgagctgttc gaggaccgtg tcgtaggtgc tgtgcgagcc
     6781 ggtcagcctg ggcagatggt cgaagcagta gtcgttctcg gcggtcgcgg cctcgcccca
     6841 gtaggccttg agcaggctga cgacgtagtt gcgcatgtcg ccccagtagc ccttgtcggt
     6901 gcgcatggct ccggtgaagg tgtccaggtc ctcggccttg tgcgcgtggg gcatcgggat
     6961 gtagccgggc agcaggttga agagggtggg gatgtcgctg gagccctgga tgctggcgtg
     7021 tccgcgcagt gcctggatgc cgccgccggg ccggccgatg ttgccgagca ggagctggag
     7081 cacgcaggcg gcccggatgt actgggctcc gacggtgtgc tgtgtccagc cgacggcgta
     7141 ggcgaacgcg gaggtgcggt cgggtccgga gttgtccacg agggcgcggc acacgcccag
     7201 gaacgtctcg ggcgggatgc cgcaggtctc ttcgaccatc tcgggcgtgt agcgcgcgta
     7261 gtggcgcttg aggatctgga agacgcagcg cgggtggcgc agcgttcggt cgtgtgtgcg
     7321 gttcccggag acgggtgcgc cgccggagcc gtgtgactcg gagccgcccg cggcggccac
     7381 cgagcggccc tggcgggtgc gctcctcgta cagcgcgtcg cgttccccgg aggcggcctg
     7441 cacgacgtcg ccctcgtact gccagctggc ggtgtcgtag tgtccggtct cctggttgag
     7501 cccggagaag acgccgtcca ggtcctcggt gtcgcggaag tcctcgccga cgagggtgga
     7561 ggcgttggtg tagtcgagca cgtactcgcg gaagtccgcc tcgtgggaca gcacgtagtt
     7621 gatgatgccg ccgaggaagg cgatgtcggt gccggcccgg atcggcacgt gcagatcggc
     7681 cagggcactc gtccgggtga agcgcgggtc gacgtggatg atcgtggcgc cgcgtgcctt
     7741 ggcctccatc acccactgga atccgaccgg gtgcgcctcg gcgaagttgg agccctcgat
     7801 gacgatgcag tcggcgtgct ggaggtcctg gaggaaggtg gtggcgccgc cccgcccgaa
     7861 cgaggtgccg agcccggcga cggtggagct gtggcagacc cgcgcctggt tctcgatctg
     7921 caccacgccg agggccgtga gcagcttctt gatgaggtag ttctcctcgt tgtccagcgc
     7981 cgcgccgccc agcgccgcaa ggcccatggt gcggttgacg cggacgccgt cgcgttcgtg
     8041 ctcccagccc tggcggcgcg tgcggatgac ccggtcggcc accatgtcca tggccgtctc
     8101 caagtcgagc cgctcccagt cggtgccgtg gggccgccgg tagagcactt cgtggcggcg
     8161 ggcgtcgccc gtggtcagct ggagtgtggc cgcgcccttg gggcagagcc tgcccctgct
     8221 gacgggggag tcggggtccc cctcgatctg gacgacctgc tcgttcttga cgtacacgtc
     8281 ctggccgcag ccgacggcgc agtagggaca gatcgacttg acgacacggt cggcggagtg
     8341 ggtgcgcggc cgcagggagc gggtgtacgc ggaggaggcg gccgcgcctc ttcccgtcgg
     8401 atcgccgccc atggcctgcc ggtacacggg ccagtccttg atccaggttc gtacgcccat
     8461 cccacgtcct cccagcgggt cggcctcatg caggggctcg gatgtacggg ctcaggcggc
     8521 cttgccggag ctgccgctgc cggcaagtgc ttcgagtgct tcgagcagtt gttcgcgggt
     8581 cattttcgaa cggcccttca ctccctggtc gccggcgcgc cggtagagct cgtccttgcc
     8641 caggtcccgg agcggcgaag tgttcttcga ggcacctgtc cggcccttcg gggcccccgt
     8701 tcggctcttc gaggtgcctg cccggctctt ccaggcacct gtcccgctcc tggacgtgct
     8761 ctgccgcctc ttcgcaggat gcgtgcggtc tctggcggtg gatttctggc ggccgcctcc
     8821 ggtcttccgg cccccgtcgc cgcccttctt cccggagcgg gcccgttcga tactgcggtt
     8881 gagggcctcg ctgaggtcca ccacgttggt ggcctccggg gggccctcct cgggggtgag
     8941 ttcctcacct tcggccttgg cctggaccag cgcacgcacc cgggcctcgt agcggtcgct
     9001 gtagtcctct gggtggaagg tggtgctcat gctgtcgatg agctgccgcg cggtcttcag
     9061 ctccttgctg tccgagcgct gacgtcctgg cagttcggac agctcctcct cgggatcgcg
     9121 gacctcgtcc gcccagtgca gggtgtgcag cgccaggacg ttctcgccgg cgcggagggc
     9181 gaccaggtac tccttgccgt gcatgacgaa ggtggcgatg cccgtcttcg cggaggactc
     9241 cagagcggca cggagcagtt cgtagggctt gcggtacttc tcgtcgccgg gcgagaggta
     9301 gtaggagcgc acgtagtaga ccggatcgac ctcgtccgcc tccacgaagc cgctcacgtc
     9361 gatgacctgg gacttgccgg gggcgatctc ctccagctcc tcccgctcga cggtgacgta
     9421 ctggccgtcg gcgatctcgt atcccttgac gatgtcgtcg tagccgacgc tctttccggt
     9481 gcgttcgttc acccgcttgt tgcgcacccg gtcgttggtg ccgcgctgca actggtggaa
     9541 atgggtggtg tggtcctcgg tggcggcgta catccgcacc gggaccgtca ccagcccgaa
     9601 ggtgatcact ccgctccaga ccgggcgtgc catcgcttct cctgctcctg agtggtcccg
     9661 ggccgcgggg gacctcgggc ccgggacgag cgcgctccca ctgtcgcccg aggtgcgcgc
     9721 caccgcatcc cgggccgtgc gttcgtgtgc ccgggtttca cgcccccggc gcctcacacc
     9781 ccccacttcg cacgcaccgc tccgccgagc cgcgcccctg cgccccgcgt gcttcgtacg
     9841 gaatcggtgc ggcgggagtc gcgggtccct cggtggggaa agccgattac tgagagcaca
     9901 ccattcccgc acgcttcgca tccgcccggg tgatccggat gtccggcacg gcccgggtga
     9961 tccggatgtc cggcacggag agatcaggag gcgctccggt atgacgactg aggaactctc
    10021 cgacacgcac ggtctgcccg ccgccccgtc cctgctgtcc accgcacacg agcggatcga
    10081 gccgctgctg cgggaggccg tcggcgctct ccagcccgag ctgcgacgcg tctgcggcta
    10141 ccacttcggc tggagccagc cggacggcag ccccacctac ggcgtcaccc ccgagccccc
    10201 gctgcgcgcg gccctgacgc tgtgcgcggc gggcgcgagc gagaccgggc gggacggttc
    10261 cgccacggac cccacggctg cggcgctgcc cggagccgcg gccgtcgaac tggtgcacaa
    10321 ctgggcgtcc ctgcacgacg acgtgatgga cggtgaggcg ctccggcacg ggcgctccgc
    10381 ggtgtgggcc gtctacggca ccggctgggc cgtcctggca ggggacgcgc tcctgggcgc
    10441 ggccacccgc cgcgtgctgc ccacgggcgc ggaccccgag gcggagggcg ccgtgctgcg
    10501 tctgctgacc cgcaccacgt cgcggctggt ctccggccgg tcggccgaac tcgcgctgcg
    10561 gcgccgcgcg cccgagggca tcagcgtgga ggagtacgcg gtggtggccg gtgcgcggcg
    10621 cagttcgctg ctggagtgcg cgctggccgg cggcgcgctg ctggcggggg cggacgagcg
    10681 ggtggtcgag gcgctgacgc gtgcaggaca ccacctgggc gtggcggcgc aggtggcccg
    10741 cgacatcgag gacctgtggt cggggacggc gttgagcggg cgtcccgtca tgagcgggct
    10801 gcgggagggc gggcccagcc ttccgctgat cgcggcactg cgcgcgggca accccgcggc
    10861 gcggacgctc gcccagtcgc tgggcggcgg tcccgcctgt ccgccgccgc cggacgagct
    10921 ggccgctctc atcgaccacg cgggagggcg cgccgccgcc gacgagatat cggcctggca
    10981 gctgaccgaa gcgctcaccc agttggacaa ggccgcgctg ccgcccgcca cccacgccgc
    11041 gctcacggcg ctgttccgtc acacggtcgc ccggggctga gggggccctt ccggagcgtc
    11101 gttacggagc ccgggtgctc cctgtgggcc ggtcggggga caggcgctgt gtcgctcccg
    11161 gggagcgagg gcgagtcgtc gtccagtgcg tttatcgcac ttgtatgact ggctcgcccc
    11221 gcaggagcat ccatgcgcac acacgttccc cccggccgcg gtcgccgctc gggccgccgt
    11281 cccggccgcc gccgcgcacc gcgcgacgcc cgcctggcct cgccgatccg cctctcttct
    11341 ccgatccggc ccttcctccc cacggacctc gtcgcccgtg cccgcctctt ccggcgcgtg
    11401 cgcctcctcc cgcgcatcca tcccgtgggg cgcgtccgtc ccactcgcgg tcgcctccgc
    11461 gcacgcggtc tcctcgcggc tgtcgccgtc accgcactgc tcggcggcgt cgccggatgc
    11521 ggaacggccg cggacggcgt gcgcagcggc tccgcgggga ccggggcgcg cgcggagcgc
    11581 ggggagggac agcagtccgt gcacgagcgg gggcagggcg acgcgcaggg cttctccctg
    11641 gtggccaccg gcgatctgct cgtccacgac tcgatcatcc ggcaggcgcg cgcggacgcg
    11701 ggcggcccgg gctacgactt cggccgcatg atcgacgcgg cgaagccgat ggtgcggaag
    11761 gccgacctgg caatctgcca catggagacc gtctacgggc ccgacggcgg accgttctcc
    11821 ggatacccgc tcttcaagac cccgccgcag ctggcgcgct ccgtcaagaa cgtgggctac
    11881 gactcgtgtt cgacgggttc caaccacacg ctggacgaca gcagcgacgg cgtgcaccgc
    11941 accctggagg ccatggactc cgcggggctc cagcacgtgg gctccgcccg ctctgcccgc
    12001 gaacgcgggc ggcccgccgt gctgcgggcg ggcggcgcca aggtcgcaca gctggcgtac
    12061 acctacggca ccaacggcat ctccgtgccc gagaacaaac cctggctcgt caacctgatc
    12121 gagccccagc gcatcatccg ggacgcccgg gccgcacggc gggcgggcgc cgacgtggtc
    12181 gtcgtcagca tgcactgggg taccgagtgg cagcaaaagc ccgaccagct ccagcggtcc
    12241 atggccaaga cgctgaccgc ctcccgctcc cacggccgcc gggacgtcga cctgatcctc
    12301 ggcacgcacg cacacgtgcc gcaggcgtac gagaaggtca acggcacctg ggttgtctac
    12361 ggcatgggcg accagatcgc gggcaagatg aacgaccccc gcggctccat gggcaccgcg
    12421 gcgcgtttcc acttcgtccc gcccggccgc acctccgacc gggggcacaa gggcgcctgg
    12481 acgatcgaca aggcgtcctt cacccccttc ctgatgcggt cctcgccccg gtacacgctc
    12541 gtcaacctcg cgtccggcag cagcaggtcg gccggcgacc ccgcacagga caaggcctac
    12601 gagaccatcc gcgaggccgt cttcagccgg ggcgccaaga aggacggcct gcgcatggtg
    12661 ccgtgacgag ccggcccggt ccggcgtggt ccggccccgc ccccactacg ccggaccggg
    12721 gccggatacc gcttcgggac gccgtgccta cgccggccct gagcgtcccg ggcccgccgg
    12781 agggggcggg tcagacgttc tgaagggact cgtcgtggcc ggcgctcgga gggttgtggg
    12841 aacactgagg gctgcctccg gtggcgtcac cggaacccgc accggcgtgc tcctcctcgg
    12901 ggacggagat gacccagtgc gtggcccggc gcggccgcag gtagcaggcc cagtagaggg
    12961 cggcggcggc gacgatgcct ccggtgacgg cgaggctctc ggcgctctgc tggtacagca
    13021 cccagatcag tgcggccatc aggagcgcgg ggaggacggg ccacagcggc atccgccagg
    13081 cggcccggtg tttgaacgcc tcccgccggg cggccagcgc accgagggcg acgaagacgt
    13141 acaggccggc caccgccacg ccggtgacct cgttgagcac gtcgaggttg acgaagcaca
    13201 ggacggctcc ggggacgccg acgacgaggg tggccaccca gggcgaggcg aagcgcgtgc
    13261 ccagccggga gagggcgcgg ttgaccgggc cgggccaggc ggcgtcgcgg gcggaggcga
    13321 agacgacgcg cgagttctgg atcaccatga cgatcgcggc gttgatgatg gccagcgcga
    13381 tgcacaggct gatgaacgtg ccgacggcgg agttgctcca ctgctggacc atgcccgcga
    13441 tgtcgccgcc cgcgagggcg tgcaggtcgg gggcgccgag ggtgagggcg acgacgggga
    13501 cgatgacgat ggcgaagccg atgctcagcg tccacagcac ggtgcgggag acggtgcggc
    13561 gcgggttctc catctcctcc gccaggtaca cggcggtggt gaagccctgg aggatgaaca
    13621 gcgcggtggc cagccccgtg acgatcagtc cggccgtgac cgggctggtg tgaccctgtc
    13681 cggagtccat gacggggtgg aggaggacgg aggcggggcg ctgggcgtgg gtgaagccga
    13741 ggaaggcgac gatggcggcg cccacgacct ccagggccag gaagacgccg gtgatccagg
    13801 cgttggcccg caggtcgagc aggcccatgg cggtggacag cagcatcacg gcggcggccg
    13861 cgacgcgcgg gtcgagctgc acgagagggg cgaggtagtc cgcggtgccc agggcgatga
    13921 tgggcggcac gatcatgacg acgatcagtg agagaacgaa gaccagccag cccgccagcc
    13981 tgcccatcag ggtgccgacc atggcgtact caccgccgga cgacgggacg agggtgccga
    14041 gttcggagta ggtgaaggcg acgccgacgc acagcagggc ggcgatggcg agggtgaggg
    14101 ccgttcccgt gccgagcgtg ccgaaggagt ccggcacgat cacgaagagc gacgaggccg
    14161 gagtcagaca ggacagggtg agcagggtgc cgcccacgac gccgatggag cgcgtgagcc
    14221 ggggccggct ggtgtcttcg tgggtgtcgg tcatgcggtt ccgttcgtac tgcgtacggg
    14281 atacggcgcg tactgggcgg ggagcggtgt cgcctccggc gcggcaccgc gggcgcggtg
    14341 cgggatgtgc ggtgccggaa gcgcgttccg gtcagcgcat acaagcggtt gcggagaagt
    14401 ggagtcaagg gctccattca acggaatccg tcatgtgagg aggtgttgac cactgttccg
    14461 agggggcgca gccccttatg gagaggtttt tggcggtcga ggaaaccgca gcgacgattc
    14521 ccaggttttc ccggccgtca ccggcttctc acatcacgag actcaccgtc tgtatcagtc
    14581 ccagcgcgat cacggacgcg ccggagacgg tcagcgtgac cgtcttgagc gtgccccgcg
    14641 tcgtctgtcc gagcagggtc tgcaacagcc agaaggtgtt gctcgtggcg tggatggcga
    14701 acagcgagcc cgcgccggcc gcgagcgcga tcagtaccgg ctgcacgtcc aggctgggcg
    14761 ccacgggggc gaggatgccc gctgccgtga tggcggaggt ggtgaccgaa ccgatcgcca
    14821 tgtgcaggac ggcggcgatc agccacacca gtgcgagcgg tgcccacgtg ccggccgaga
    14881 acgagtcctt gatcaggtcg ccgagcccca cggcttccac cacggcggcc agcgagccgc
    14941 cgaccccggt cagcaccagg atctgcccgc tggtgcggaa accctgcccg aacgcctctc
    15001 cgacggcccc ggccggcagg cggcgccgtg cgacgagaca ggcgaggatc agccccgtca
    15061 acagcccgac gaccgggtcg ccgaggaagc cgacgacggg tgagtcccag ccggcgacct
    15121 gggcgaaggc gccggtcgcg atcaggacga gggccagcag cagcggtgtg agcgagagcc
    15181 ccaggggcgg cgcggtgccg tcgccgcgcg cggtaccggc gtcgccgtcc gccgccactg
    15241 cgtcaccgac gcccgcacca gcatgccctg caccaccctc acctacggcc gcgtcgccac
    15301 tcatcccggc gcctccgtgc gccgtcgcgt ctccgcgcgc tgccgcgccg tcgtgggcga
    15361 ccgcaccgtc atgaaagccc gcgccgccct cgacggccgc gccgccctcg acgaccgcct
    15421 cgccctcagc gaccgcgctc tcgtcccggt ccgggttcca gaagccgcgc ttgaccagcg
    15481 cgctgaacag cagcagggtc agcaggatcg tcacggcggc cagggggaag ccgtacagga
    15541 gcatgatgcc cagcgggatg tccagcaggc ccgcgagggc cagcgcgccg atgccgggca
    15601 ccgacagcgc gatgccgacc tcgacgccca gcgccatggc ggccgccatc cgggcgagtc
    15661 cgccaggacc gatgcgggtg cccagcgacc gggcgagcgg ggcggtcatc acgagcagca
    15721 cgtcggcgaa gatggactgc aagacggtgc ccatcgtgat ggcgaaggag tagggcagcc
    15781 gcttggggcc cagcgtccgc agcagcaggg tgaccagctt gtcgatggcg ccgagcgcgg
    15841 agagcagggt gcccagcagc acgccgagga cgatgaggag ccccacctcg gccatcaggt
    15901 cgccgaagcc cttgttgacc gtcttcaggg tgcgttcggc gcccaggccg ccggcgaggc
    15961 cgaggtacac ggcgccgagt acgagcgcca gcgcggggtt gaccttcgct ttgaggatga
    16021 gcacgaccac cgccgcgatg gcgatggccg tgtgcaccaa aggtgccggg ttgtccatcg
    16081 ttcgtctccc gtccgacctg cggaaacccg atgttccgca gccggatcat ggtcaacgcg
    16141 gcacgccgtg aggggaatgg gggtctcacc atgtggcccg cgcctcggcc ggacggggac
    16201 tcggccgagg cgcgggcagg tgtacgcccg cgcggctcag tcgccggcgg tgacccgcac
    16261 gtagtcgacg gtcatctgct gcgggaaggt cgtcgagccg tccgggtcgc cgggccagta
    16321 gcctcccacg gccaggttga ggatcaggaa gaacggtttg tcgaacaccc acgggttggc
    16381 gccggtatcg gcgggggtgc gcgtctggta gacgttgccg tccaccgacc agctgatggc
    16441 gccgggagac cagtcgatgg cgaagacgtg gaagtcgtcg gcgaaggccg cgccgtccgg
    16501 cagggagtag gcggcgccga tgccgcccga gccggagtag ccggggccgt gcagcgtgcc
    16561 gtgcaccgtg ttcggctcga agccgacgtt ctccatcacg tcgatctcgc cgcaggcggg
    16621 ccatccggcg ctgccgatgt cgtcgccgag catccagaag gccggccaca tgccctggcc
    16681 ccgtggcact ttgatgcgcg cttcgacgtg cccgtgggtc tgggtgaact ttccggcggt
    16741 gttcagccgt gccgaggtgt actcgcacgt gccgtaccag cactggtagt tgccggggtt
    16801 ctctttgcgt gcggtgacga cgaggttgcc gttgccgtcg agcgcggcgt tgtcggtgcc
    16861 gggggtgtag tactgccgtt cgtggttgtc gacgttgtct ccggtctcgg tctgccactt
    16921 gccgctgtcg gcaggggagc cggccgggcc gtcgaagtcg tcggagaaga cgaccgcttg
    16981 tgcgccgctg cccggccgtc cgctgtccgc ggcgccggcc gagcccgtgg cggggaggag
    17041 cgcggcggtt gtgcagcaca gcagggtcgc tccgcacaca gctgtgcgga gccgccaggg
    17101 aagtctcatg tcagcccgtc ctttcgtggg ggtggacgta gggcgtgctc atgacaagaa
    17161 gtgacaagac atcaactgag gcgcgcgtag cgcttccgct gagccccggg ctttcttgat
    17221 gacttgttgt aagcctgccc gaacgagccg tcaaggcttt ggtccagacc gatgtgtgtt
    17281 caagaggtgg cgacaggtgt gaggggcttg ctgcctgtgc gcccgtaagg cccgctcgcg
    17341 cggccctctt ccaggaccgc gggagacgcg gcggggctca gtccgcggcc cgcccgccga
    17401 aggtttcgac gatccgttgg gcggcgcgtg tggccgtcag ggagccctcg cggacgcgct
    17461 cttccagcag gggcgcgagg cgccgtaccc cggggtgctg ttcgaggcgt cccagcaggt
    17521 cgtcgcggac catggaccac acccattcga cctgctggtc gcggcgtttc gcggccagtt
    17581 ccccggtgga ctcctggact tcgcggtgcc gctcgacgcg ctcccacacc tcgtcgagtc
    17641 cggtgccctc ccggccgctg cacgtgagca ccggcggggt ccaggaggcg tcggccgacc
    17701 gcatcagccg cagcgcgccc gccagttcgc gggcggcgga gcgggcgtcg cgctcgtgcg
    17761 ggccgtcggc cttgttgacg gccagtacgt cggcgagttc cagcacgccc ttcttgatgc
    17821 cctgaagctg gtcgcccgtg cgggcgaggg tgagcagcag gaaggagtcc accatctggg
    17881 ccacggtcgc ctcggactgg ccgacgccga cggtctcgac gaggacggcg tcgtagcccg
    17941 cggcctccat cacgatcatc gtctcgcggg tggccttggc gacgccgccg agcgtgcccg
    18001 ccgtggggga ggggcgcacg aacgcgtccg ggttgacggc gagccgctcc atcctggtct
    18061 tgtcgcccag gatggagccg ccggtacggg tggaggaggg gtcgacggcg aggacggcca
    18121 cccggtggcc gcgctcggtc agcagggtgc ccagcgcgtc gatgaaggtc gacttgccga
    18181 caccgggtac tccgctgatg ccgacgcgcc gggagccgcc cgcgtgcggc agcagcgccg
    18241 tcagcaactg ctgcgccagc tcccggtggt cggccctgcg ggactccacc agcgtgatgg
    18301 cccgcgcgat ggaggcgcgg gatcctgcca gtacgccctt ggcgtagtcg tcggggtcga
    18361 tggtccgggg cacgttttca gccctcaccc tccgccgggc cctcggagcc cgtcgcgcct
    18421 tcgctcggct cggcggactc cgccggctcg gccaactcgt cgtggccgag cgaggcggcc
    18481 agctcgcgca gcaggtcgta cgccgcctcg gggatgaccg tgccgggcgg gaagaccgcc
    18541 gtcgcgcccg cctcgtgcag cggttccacg tcggcgggcg gaatcacacc gccgacgacg
    18601 atcatgatgt cctcgcgtcc ggccgccgca agttcctccc gcagcgccgg tacgagggtg
    18661 aggtgtccgg ccgccagtga ggagacgccc acgatgtgcg cgtccgcctc gacggcctgc
    18721 cgtgccactt cggccggggt ctggaagagg ggaccgacgt ccacgtcgaa gcccaggtcg
    18781 gcgaacgcgg tggcgatcac cttctggccc cggtcgtgcc cgtcctggcc catcttggcc
    18841 accagcagcc gcggcctgcg gccctccgcc tcctcgaagg cgtccaccag ctcccgggta
    18901 cgggccaggg acgacgacac tcctgcctcc tcgcggtaca caccggagat cgtacggatc
    18961 tgtcccgagt gccgcccgta gaccttctcc agcgcctcgg agatctcccc gacggtggcc
    19021 atggcgcgcg ccgcgtccac ggccagggcc agcaggttgt tctccaggcc cggtcctgag
    19081 gccgccccgg cggcccgggt gagggcctcc agcgcggcgc ggcaggcgcc ctcgtcgcgc
    19141 tcctcgcgca gccgccgcag cttggccacc tgctgggcgc ggacggagga gttgtcgacc
    19201 ttgaggacgt cgatctgctc gtcgctcgcc gcccggtact tgttgacgcc gatgaccggc
    19261 tgccgccccg agtcgatccg ggcctgggtg cgggccgcgg cctcctccac gcgcagcttg
    19321 ggaatgcccg cgtcgatggc cttggccatg ccgccggcgg cctcgacctc ctcgatgtgc
    19381 tgccaggccc gtgccgccag gtcgtgggtg agccgctcca cgtaggcgct gccgccccac
    19441 gggtcgatca cccggcaggt gcccgactcc tgctggagca gcagctgggt gttgcgggcg
    19501 atgcgcgccg agaagtcggt gggcagcgcc agggcctcgt ccagcgcgtt ggtgtgcaac
    19561 gactgcgtgt ggccctgggt ggcggccatc gcctcgacac acgtgcgggt gacgttgttg
    19621 aagacgtcct gcgccgtcag cgaccagccc gaggtctgcg agtgggtgcg cagcgacagc
    19681 gacttggggt tcttcggctc gaacccgttc acgagcttcg cccacagcag ccgcgccgcg
    19741 cgcagcttgg cgacctccat gaagaagttc atcccgatcg cccagaagaa cgacagccgg
    19801 ggggcgaaag cgtcgacgtc catgcccgcg tccagtccgg cgcgcaggta ctccacgccg
    19861 tccgccagcg tgtacgccag ctccagatcg gccgtcgcgc cggcctcctg gatgtggtag
    19921 ccggagatgg agatggagtt gtagcgcggc atcttctgcg aggtgtaggc gaagatgtcg
    19981 gagatgatcc gcatggaggg ctgcggcgga tagatgtagg tgttgcggac catgaactcc
    20041 ttgaggatgt cgttctgtat ggtcccggcc agtttctcgg gcggtacgcc ctgttcctcg
    20101 gccgcgacga tgtagagcgc cagcaccggc aggacggcgc cgttcatcgt catcgagacg
    20161 gtcatccggt ccagggggat gccgtcgaag agctgccgca tgtcatagag cgagtcgatc
    20221 gccacgcccg ccatgccgac atcgcccgtc acgcgcgggt ggtcgctgtc gtagccgcgg
    20281 tgggtgggca ggtcgaaggc gaccgagagg cccttctgtc cggccgccag gttgcggcgg
    20341 tagaaggcgt tggactcctc ggccgtggag aagcccgcgt actggcgaat ggtccacggc
    20401 tggttgacgt acatcgtcgg gtacgggccg cgcaggtagg gggcgatgcc cgggtacgtc
    20461 cccaggaagt cgaggccgtg caggtcctct tcggtgtaga ggggcttgac cgcgatgccc
    20521 tcaggggtgt gccaggccag gtcctcgacg gagcgcccgg tgcgctcttt gacggtctcc
    20581 cgccaccgct cgccgtcgga cccacggccg ccctcggctc cgcgctcggc cccggggtcg
    20641 gattcgaggc cgacggtggt gaagtcgggg atcgcggcgg agtcctccgc gcctgtcgtc
    20701 tgccggctca tgcgtcgacc cccatgcggt cgaggaggga ggtgagggcg gcgacggcgt
    20761 caccgcccgc gtggacgaac gcgtcgacac cggcggcccg gtacgcctcg cgccgctccg
    20821 cgtcgggttt ccccgcgagg agcacgcgcg ccgcgcccgc ccgcttgagc gcggtggcga
    20881 cctgtgccgc ctcctcggtg tacagcgcgt cgctggagca caggcacgcc accgtggcgc
    20941 cgctggcggt gaacgcggcg gccgcggtgg cggcgtccac cgtcaccgga tcgtgtaccg
    21001 gctggatgcc gcccgcctgg gcgaggttgg agacgaagga gacgcgtgcc gtgtgcgccg
    21061 cggcgggacc gagcgcggcc
//
