LOCUS       NZ_QOIM01000040        22739 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces reniochalinae strain LHW50302
            NODE_3_length_463606_cov_17.2509_ID_5, whole genome shotgun
            sequence.
ACCESSION   NZ_QOIM01000040
VERSION     NZ_QOIM01000040.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces reniochalinae
  ORGANISM  Streptomyces reniochalinae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 463606)
  AUTHORS   Li,L.
  TITLE     Streptomyces reniochalinae sp. nov. and Streptomyces diacarnus sp.
            nov. from marine sponges
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 463606)
  AUTHORS   Li,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JUN-2018) Department of Pharmacy, Ren Ji Hospital
            School of Medicine, Shanghai Jiao Tong University, Pujian, Pudong,
            Shanghai 200127, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-FEB-2016
            Assembly Method                   :: A5-misseq v. MARCH-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003323735.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 01:54:27
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,751
            CDSs (total)                      :: 6,669
            Genes (coding)                    :: 6,475
            CDSs (with protein)               :: 6,475
            Genes (RNA)                       :: 82
            rRNAs                             :: 6, 4, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 4, 3, 2 (5S, 16S, 23S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 194
            CDSs (without protein)            :: 194
            Pseudo Genes (ambiguous residues) :: 0 of 194
            Pseudo Genes (frameshifted)       :: 66 of 194
            Pseudo Genes (incomplete)         :: 154 of 194
            Pseudo Genes (internal stop)      :: 16 of 194
            Pseudo Genes (multiple problems)  :: 41 of 194
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:03:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 245124
            Orig. end                         :: 267863
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QOIM01000040.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22739
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="3"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22739
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22739
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12739](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12739
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    complement(796..810)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.87"
                     /tool="antismash"
     gene            1112..2593
                     /locus_tag="DQ392_RS22965"
                     /old_locus_tag="DQ392_22945"
     CDS             1112..2593
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602270.1"
                     /locus_tag="DQ392_RS22965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22945"
                     /product="NCS2 family permease"
                     /protein_id="WP_114017584.1"
                     /transl_table=11
                     /translation="MTQSKVGPTTSPEDAGPGSRIPAGRSWLDRYFHISARGSSYGQEV
                     RGGITTFMAMAYIVLLNPVILSVPDAAGHRLDGGEVTTATALAAAVTTLVMGFIGNVPL
                     AMAAGLSVSAVMSTQVATEMTWGNAWAMCVIYGAVIILLVVTGLRELIMNAIPMALKHA
                     ITMGIGLFVCLLGLVQAGFVTSTGGPGGLPGVKPIQLGTAEVLTGWPVLCFSVTVLLIF
                     ALQVRKVPGAILIGIVGGTVIAAVIHQFAGLTKKDWGGHNAPEFPGSVVSSPDFGLFGS
                     VSFDGLGDVGAISIGVIVFTLVLAGFFDAIGTIIGIGQQAGLADKEGRMPGLAKALTID
                     GAGGVMGGLAGASGQTVFVESTAGVGDGARTGFASVISGLGFTLCLFFTPLAQMIPPQV
                     AAAALVVIGSMMITNAMHIDWSDPATSIPVFLTTVLMPFAYSITTGIGAGVISYVLIKA
                     VQGKFREPGWLMWVLGFVFLAYFALNPIEQWLGAK"
     gene            2702..3865
                     /locus_tag="DQ392_RS22970"
                     /old_locus_tag="DQ392_22950"
     CDS             2702..3865
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470579.1"
                     /locus_tag="DQ392_RS22970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22950"
                     /product="XdhC/CoxI family protein"
                     /protein_id="WP_114017585.1"
                     /transl_table=11
                     /translation="MLDIAAQLHRWCEEGRDFAVATVVGVSNSAPRQVGAALAVDADGE
                     AVGSVSGGCVEGAVYELCQEALECGDSIRQTFGYSDEDAFAVGLTCGGIIDILVTPARA
                     GTRARAVFTAAVAEAAQRRTAALVRLVEGPDELLGGALWLDAEGQPHGALGGAAELDAT
                     AVAEGRALLDAGRTATVTVGADGSRCGAPVTLLVESSVPAPRMLVFGAIDFAAALVRIG
                     TFLGYRVTVCDARPVFATARRFPDADEVVVDWPHRYLDTQELDGRTVVCVLTHDAKFDV
                     PLLERALRLPVAYVGAMGSRRAHLERLERLREAGLTDAELARLRSPIGLDLGARTPQET
                     ALSIAAEIVAVRQGGTGVPLNGAHTPIHHDRGPAPGSLTGGTDRATG"
     gene            complement(4099..5073)
                     /locus_tag="DQ392_RS22975"
                     /old_locus_tag="DQ392_22955"
     CDS             complement(4099..5073)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357188.1"
                     /locus_tag="DQ392_RS22975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22955"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_245981796.1"
                     /transl_table=11
                     /translation="MADGAPAGRRRHPFVAALCALTLLVLSVPLGFRAADEDGPTPVPQ
                     LLAFLPWFLVPAWLALVGAALARRWLVLVWALVVLAGTGWFLRPYGPPAPDGAAGLAGK
                     AQFRVLTANLKYGGATRDLVETVRRERPQLVAVQECDNPCAKALNGSVLREEYPHRLVT
                     GVDGGARGSALLSVYPLHDRGQVSGRLSMPGAVADIHGERVALQVAHPMPPTPGDTATW
                     RSELAGLRSYAAARRLPTLIAGDFNSSQDHAGFRAVLDTGMHDAARLLGNSRTPTWPTR
                     TTPVLGAQIDHVLLSEEMVPVDGKFLDLRGTDHRALLVNVKLL"
     gene            5234..6919
                     /locus_tag="DQ392_RS22980"
                     /old_locus_tag="DQ392_22960"
     CDS             5234..6919
                     /NRPS_PKS="Domain: AMP-binding (50-451). E-value: 4.1e-84.
                     Score: 274.5. Matches aSDomain:
                     nrpspksdomains_DQ392_RS22980_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547551.1"
                     /locus_tag="DQ392_RS22980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22960"
                     /product="AMP-binding protein"
                     /protein_id="WP_114017587.1"
                     /sec_met_domain="AMP-binding (E-value: 6.4e-93, bitscore:
                     306.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPSTPTEAFRAARDTLLTHRTDYEAARAAFTWPRPEHFNWALDW
                     FDRIAEGNDRLALHIVEEDATERRVTFAQMRERSNRVANWLRGRGVVPGDRVIVMLGNQ
                     VELWETLLALMKLRAVVIPATPQLGPRDLTDRVTRGEARHVVARAADTGKFAEVAGDYT
                     RVAVGSGGTPEAGWLAYEDAYEADGAFDPRGVTRADDTLLLYFTSGTTALPKLVEHTHV
                     SYPVGHLSTMYWIGLRPGDVHLNISSPGWAKHAWSNFFAPWNAEATIFIHNYTRFDAGR
                     LMAEMERGGVTSFCAPPTVWRMLIQADLGKLAAVPREVVAAGEPLNPEVIEHVRRVWGV
                     TIRDGFGQTETAVQVANTPGQVLKTGSMGRPTPGFDVTLLDPVTGEAGVDEGEICLDLA
                     GSPVGLMRGYHGDTERTERAMADGYYRTGDIGSRDADGYLTYVGRSDDVFKASDYKISP
                     FEVESVLLEHEAVAEAAVVPSPDPVRLAVPKAYVVLADGYAADAQTARVLFAHCRERLA
                     PYKRVRVVEFAELPKTISGKIRRVELRAHAAGETGTPGVEHRDG"
     aSDomain        5384..6586
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DQ392_RS22980_AMP-binding.1"
                     /evalue="4.10E-84"
                     /label="DQ392_RS22980_AMP-binding.1"
                     /locus_tag="DQ392_RS22980"
                     /protein_end="451"
                     /protein_start="50"
                     /score="274.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="EGNDRLALHIVEEDATERRVTFAQMRERSNRVANWLRGRGVVPGD
                     RVIVMLGNQVELWETLLALMKLRAVVIPATPQLGPRDLTDRVTRGEARHVVARAADTGK
                     FAEVAGDYTRVAVGSGGTPEAGWLAYEDAYEADGAFDPRGVTRADDTLLLYFTSGTTAL
                     PKLVEHTHVSYPVGHLSTMYWIGLRPGDVHLNISSPGWAKHAWSNFFAPWNAEATIFIH
                     NYTRFDAGRLMAEMERGGVTSFCAPPTVWRMLIQADLGKLAAVPREVVAAGEPLNPEVI
                     EHVRRVWGVTIRDGFGQTETAVQVANTPGQVLKTGSMGRPTPGFDVTLLDPVTGEAGVD
                     EGEICLDLAGSPVGLMRGYHGDTERTERAMADGYYRTGDIGSRDADGYLTYVGRSDDVF
                     KA"
     CDS_motif       5843..5896
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS22980_0001"
                     /evalue="6.70E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="DQ392_RS22980"
                     /protein_end="221"
                     /protein_start="203"
                     /score="12.7"
                     /tool="antismash"
                     /translation="LYFTSGTTALPKLVEHTH"
     CDS_motif       6440..6487
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS22980_0002"
                     /evalue="5.90E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="DQ392_RS22980"
                     /protein_end="418"
                     /protein_start="402"
                     /score="12.3"
                     /tool="antismash"
                     /translation="VGLMRGYHGDTERTER"
     CDS_motif       6554..6619
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DQ392_RS22980_0003"
                     /evalue="3.30E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="DQ392_RS22980"
                     /protein_end="462"
                     /protein_start="440"
                     /score="10.3"
                     /tool="antismash"
                     /translation="YVGRSDDVFKASDYKISPFEVE"
     gene            complement(7020..7739)
                     /locus_tag="DQ392_RS22985"
                     /old_locus_tag="DQ392_22965"
     CDS             complement(7020..7739)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470582.1"
                     /locus_tag="DQ392_RS22985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22965"
                     /product="hypothetical protein"
                     /protein_id="WP_114017588.1"
                     /transl_table=11
                     /translation="MAESVLVRCPVCRREHHYAAPVYPCGCGAPIALPLLATASATQVR
                     HRTWAGSWISVRCPACGRVDEWPQPELGCGCGTTLRVPVARAGAPAREGATTGPPPVAA
                     PAAPGTPVVRPPFRPVTIRTAHDAKNAAAQYLRWLGFEGVRVAERIPASGVDVRGARVV
                     AHVDPSTTPTGVREVETLWLTGLNDSVEAVCFALAGYAPDARARAEALALPLFVLDLTG
                     TPSAINEAAQHLLRTRR"
     gene            complement(8028..9500)
                     /locus_tag="DQ392_RS22990"
                     /old_locus_tag="DQ392_22970"
     CDS             complement(8028..9500)
                     /EC_number="1.11.1.6"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357179.1"
                     /locus_tag="DQ392_RS22990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22970"
                     /product="catalase"
                     /protein_id="WP_114017589.1"
                     /transl_table=11
                     /translation="MSKSSKPTLTTEAGAPVADNQNSTSAGIGGPLLLQDQHLLEKLAR
                     FNRERIPERVVHARGSGAYGYFEVTDDVSAYTSAHFLGEVGRRTETFARFSTVADSLGG
                     PDAARDPRGFALKFYTEEGNYDLVGNNTPVFFIKDPLKFPDFIHSQKRDPFTGKQEPDN
                     VWDFWANSPEATHQVTWLMGDRGIPASYRHMNGYGSHTYQWTNAEGETFFVKYHFKTNQ
                     GIRCLSAEQGAELSGSDPNSHQTDLLQSIERGVYPSWTLYVQVMPAAEAADYRFNPFDL
                     TKIWPHKDHPLIRVGRLVLDRNPDNVFAEVEQSAFSPNNFVPGIGPSPDKMLQGRLFAY
                     ADAHRYRLGVNHTQLAVNAPKAVATGANNYGRDGLMATNAYDRHAKNYEPNSYGGPVET
                     GAPLSAPQPVTGHWGTHEAPQHTKDDDFFQAGELYRLMSEEEKNRLVANIAGGLSQVSR
                     EDVVEKNIAHFAAADPEYGKRVEEAVRELQEG"
     misc_feature    complement(9529..9540)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.05"
                     /tool="antismash"
     misc_feature    9576..9591
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.55"
                     /tool="antismash"
     misc_feature    9581..9595
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.25"
                     /tool="antismash"
     misc_feature    9734..9746
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            9757..9912
                     /locus_tag="DQ392_RS34555"
     CDS             9757..9912
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DQ392_RS34555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_181856542.1"
                     /transl_table=11
                     /translation="METLSEFTPREAGALPAEPQTSFADTDMSTAAADRCPISMCVDHC
                     VGTQTG"
     gene            10001..12739
                     /locus_tag="DQ392_RS22995"
                     /old_locus_tag="DQ392_22975"
     CDS             10001..12739
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="DQ392_RS22995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22975"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_114017590.1"
                     /sec_met_domain="Pkinase (E-value: 2.3e-11, bitscore: 38.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.2e-24, bitscore:
                     79.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDWNAVDSLRALVEEPAPPGHPAATGEHVVTPGPHWVHVRPHEA
                     DPLPGEGWKLHISSRAATLPALAEVLLPRLLRERCRFKVVRSARALALMNDGQRSPASV
                     GKAVTVYPSAGRVRGLGLELAALLRGHEGPRVLSDRRVAADAPVYYRYGPFRAQWHAGD
                     KGTLVVRLHGADGEVFDAAATLDYRQPSWARDPFKPEAGPRDPAPDDPDHGEGAAEAPL
                     LGGRYRVLEGLRESARGNVYRAEDIRAPGPAHGSARPTLVVKQARAYVAENADGVDVRA
                     RLRNERRVLETCAGVPGIPAFVDHFAHEADEYLVTTDAGDTNLLRHIRGNGALLPPVPG
                     AGPGRGLGPGGEGSAARAERERRAERFARLCGDLATTLLALHERGVVMRDISPRNVVLG
                     PRRAHLIDFGISALDGLHLPGGTPGFAPREQLDKTAEPRPQDDHFALGMVLAYAATGLL
                     PVVGAATTRLARERQLACLAAVYGESRAALRATLAQLQSGDADAGRSALLALATQPPAQ
                     EPAPAAPPPAPAPASAPRPAGPPSRTAGTASRAHLAQAVREALLAGVADYQFGGEYADF
                     PAVDASLYTGSAGVGLELLHHREEPGVAKVLDQLAAHAHDGLRRVALPPGLFSGRTGTE
                     LFLAGARAAGVAVPEGPLPGGTEWSAPEPETDVISGRAGVGLAALSLGDLDAAREQAGR
                     LAALPPRTAPRDEDDASGSDPGFGYAHGFAGTTDLLLLVAARTPDDSALLSAAHAHARE
                     LARRTVQLAAASRGPEALPMVASWCRGLAGAARTLQHARELFAGETDFAPAAEQAALAA
                     AEWVPRMETPGQCCGASGVGTMLVELARATGDGRWLEAAHEVADHLLRRSLGPDEAPAL
                     LNTELQETPYSWAQGYAGILTFLRRLEHPDSPGVLGPAASE"
     gene            complement(12791..14560)
                     /gene="gcl"
                     /locus_tag="DQ392_RS23000"
                     /old_locus_tag="DQ392_22980"
     CDS             complement(12791..14560)
                     /EC_number="4.1.1.47"
                     /GO_function="GO:0009028 - tartronate-semialdehyde synthase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="gcl"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357178.1"
                     /locus_tag="DQ392_RS23000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22980"
                     /product="glyoxylate carboligase"
                     /protein_id="WP_114017591.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.3e-49, bitscore:
                     160.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.9e-36, bitscore:
                     118.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAARAAVEILKREGVEVAFGVPGAAINPFYAALRAAGGVEHTLA
                     RHVEGASHMAEGYTRTAPGNIGVCIGTSGPAGTDMITGLYSALGDSIPILCITGQAPVA
                     VIEKEDFQAVDIASIAAPVTKKATTVKEAAQVPGVFQEAFHLMRSGRPGPVLIDLPIDV
                     QQTEIEFDVDTYEPLVPHRPAATRKQVLKALDMLAEADRPLIVAGGGIINADAAHLLVE
                     FAELTGVPVVPTLMGWGAIGDDHALHAGMVGLQTSHRYGNSTFLESDFVLGIGNRWANR
                     HTGALDAYTEGRTFVHVDIEPTQIGKIFAPDYGIVSDAHAALTLFVEVAKERKAAGQLK
                     DLSKWADTTRRRKGELQRRTHFDNVPLKPQRVYEEMNRAFGPETRYVSTIGLSQIAGAQ
                     FLHVYRPRHWINCGQAGPLGWTVPAALGVAKADPEASVVALSGDYDFQFMIEELAVGAQ
                     HHIPYVHVLVNNSYLGLIRQAQRGFDMDFQVNLEFENINTPELGAYGVDHVKVAEGLGC
                     KAIRVTEPDKLLPAFEEAKKIAAEHRVPVVVEAILERITNISMSGSDIGSVNEFEELAT
                     EASHAPTATVPLG"
     gene            complement(14721..15653)
                     /locus_tag="DQ392_RS23005"
                     /old_locus_tag="DQ392_22985"
     CDS             complement(14721..15653)
                     /EC_number="1.1.1.60"
                     /GO_function="GO:0008679 - 2-hydroxy-3-oxopropionate
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0019580 - galactarate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357177.1"
                     /locus_tag="DQ392_RS23005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22985"
                     /product="2-hydroxy-3-oxopropionate reductase"
                     /protein_id="WP_281273032.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 1.3e-10, bitscore:
                     35.5, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWERQAVMAHTAGNTKIGFIGLGIMGDPMARNLLKAGYDVTAYTL
                     ETEKVEQFAKDGGKGASSIAEAVEDADVVITMVPASPQVEAVVLHEGGVLENIREGGLI
                     IDMSSITPQTSIEVAAAAKAKGVRALDAPVSGGEAGAIEAVLSIMVGGEQEDFDAAKPI
                     LEALGKTIVLCGPAGSGQTVKAANQLIVAVNIEAVAEAVVFLKKSGVDLNAALDVLNGG
                     LAGSTVLTRKKDSILAGDYQPGFKIDLHHKDMGIVTDAARAVGAAVPAGALVAQLVASL
                     RAQGDGGLDHSALVRSVKRLSGENPDGAN"
     gene            complement(15714..16532)
                     /locus_tag="DQ392_RS23010"
                     /old_locus_tag="DQ392_22990"
     CDS             complement(15714..16532)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470586.1"
                     /locus_tag="DQ392_RS23010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22990"
                     /product="TIM barrel protein"
                     /protein_id="WP_114017593.1"
                     /transl_table=11
                     /translation="MVSSDRFTVNASILFTELPLLERPAAAAAAGFDKIELWWPWVDAP
                     VPERSALDALRSAIEDAGVQLTGLNFYAGQLPGPDRGALSIPGQESERFRANLKVAADF
                     ARSLGCKAFNALYGNRVEGVTEQEQDALALENLQLAAREADRVGGVLLIEALNAPESPK
                     CPLVSAPKAIEVVDKVNEATGLGNARFLMDLYHLSMNGEDLAGVIERYAAKTGHVQIAD
                     NPGRGAPGTGSLDFDDLIGRLDKAGYDGLIGLEYKPGDNGSAASFGWLGK"
     misc_feature    16595..16609
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 20.75"
                     /tool="antismash"
     gene            complement(16744..17625)
                     /locus_tag="DQ392_RS23015"
                     /old_locus_tag="DQ392_22995"
     CDS             complement(16744..17625)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470587.1"
                     /locus_tag="DQ392_RS23015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_22995"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_114017594.1"
                     /transl_table=11
                     /translation="MDRNGERRRRTERAARPPHSERDLGLDRHHSARIYDYFLGGKTNF
                     PPDREVAEKLLAAFPGFRNAARANRAFMHRAARFLAERGIHQFLDIGTGIPTSPNLHEV
                     VQAMAPRARVVYADNDPIVLAHARALLTGSAEGRTAYVDADITRPDSILHSAQVRETLD
                     LDRPVALCLVGLLHYITDEHDAHGIVRHLVEAIPAGSYVVLSQCTPDFAPEEWEQAMEV
                     YKMDGGSAQVRPKEEFARFFEGLDLVEPGIEVPHRWHPDQDTSQVVNLPPHDPGDATDA
                     LVSMWAGVARKP"
     misc_feature    complement(17841..17856)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            17871..18776
                     /locus_tag="DQ392_RS23020"
                     /old_locus_tag="DQ392_23000"
     CDS             17871..18776
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470588.1"
                     /locus_tag="DQ392_RS23020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_23000"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_114017595.1"
                     /transl_table=11
                     /translation="MSAMMQPSGAPSRGGASEAPNGPTALRIILGVKLRRLRQALDISR
                     EDAGRAIRGSHAKITRLERGQVGAKERDLRDLLTLYGLHDREEREEFFDLARQANSPGW
                     WYQYSDVLEDWFELHLGLEDAASLIRTYEVQFLPGLLQTEEYAHAVSRLGYPNTEPRKV
                     ARIVDLRMARQKLLHRSDPPRLWAVVDEAVVRRPFGGAEVMRAQLEHLLKVVRLPHVTL
                     QVAPFEVTAAAAGTPVTLLRFADPDLPDKVYLEHLTNAVYLDKPAEIDQYTLIMDRLCA
                     EAFSPKETVSFIEELLEELH"
     gene            18815..19069
                     /locus_tag="DQ392_RS23025"
                     /old_locus_tag="DQ392_23005"
     CDS             18815..19069
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470589.1"
                     /locus_tag="DQ392_RS23025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_23005"
                     /product="hypothetical protein"
                     /protein_id="WP_114017596.1"
                     /transl_table=11
                     /translation="MERLRVEFTTEPFDLDEAPRHAVVAREVVQGAALDAVDVGPFGNT
                     AEGSGEQVLAAVTELLRRSLEAGATRVSLQVNVIGEDEG"
     gene            19069..19452
                     /locus_tag="DQ392_RS23030"
                     /old_locus_tag="DQ392_23010"
     CDS             19069..19452
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357173.1"
                     /locus_tag="DQ392_RS23030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_23010"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_114017597.1"
                     /transl_table=11
                     /translation="MGDEPHAARHPFVVAVKPLVDAMGGAMVEPEQAQGDDVVLAWEGE
                     DVVAVRLPHLSDSLDHLLAELERRHGVPLAELDRRSKQSVVRILETRGAFSVRHGVETV
                     AGALGVSRFTVYNYLNRDDSRSD"
     misc_feature    19511..19525
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.59"
                     /tool="antismash"
     misc_feature    complement(19530..19545)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.88"
                     /tool="antismash"
     misc_feature    complement(19541..19556)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.55"
                     /tool="antismash"
     gene            19621..20139
                     /gene="uraD"
                     /locus_tag="DQ392_RS23035"
                     /old_locus_tag="DQ392_23015"
     CDS             19621..20139
                     /EC_number="4.1.1.97"
                     /GO_process="GO:0019628 - urate catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="uraD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357172.1"
                     /locus_tag="DQ392_RS23035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_23015"
                     /product="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
                     decarboxylase"
                     /protein_id="WP_114017598.1"
                     /transl_table=11
                     /translation="MTSRSTPGLTWFNTAKDAEARAALHDVCAAGSWGSALLSQRPYDS
                     AEALFAASDEATGALTDEGLDEAMAGHPPIGRPKPGDPTSAREQRSMAGASEALKAEML
                     ELNLAYQDKFGHVFLICATGKTAEEMRDAVRHRIDNSPRQEREIVRRELAKINRLRLTR
                     LTEEGAPTA"
     gene            20136..20561
                     /gene="uraH"
                     /locus_tag="DQ392_RS23040"
                     /old_locus_tag="DQ392_23020"
     CDS             20136..20561
                     /EC_number="3.5.2.17"
                     /GO_process="GO:0019628 - urate catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="uraH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612348.1"
                     /locus_tag="DQ392_RS23040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_23020"
                     /product="hydroxyisourate hydrolase"
                     /protein_id="WP_114017599.1"
                     /transl_table=11
                     /translation="MSDATSTSVSTHILDTSLGRPAAEVGVRLFVRQGDGQAAWAAHGA
                     SKTDADGRCKDFPALPEGTTHVRIVFETEPYFAQQHSSNPRSQREAAEQQDAPRVRDSA
                     PGSFFPEVTIVFAVDPGEHYHVPLLLNPFGYSVYRGS"
     gene            20567..21502
                     /gene="pucL"
                     /locus_tag="DQ392_RS23045"
                     /old_locus_tag="DQ392_23025"
     CDS             20567..21502
                     /EC_number="1.7.3.3"
                     /GO_function="GO:0004846 - urate oxidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0019628 - urate catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pucL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514695.1"
                     /locus_tag="DQ392_RS23045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DQ392_23025"
                     /product="factor-independent urate hydroxylase"
                     /protein_id="WP_114017600.1"
                     /transl_table=11
                     /translation="MPTILGQNQYGKAENRVVKITRDGDTHHIKDLNVSVALSGDLDDV
                     HYSGSNAHVLPTDTTKNTVFAYAKEHGIESAEAFGLLLARHFVDDTEPIHQARIRIEEY
                     EWERIETSDANSRFIGADEVKHSFVRKGQETRTAQITYDGEGVEVLSGLKDLTVLNSTN
                     SEFWGYIKDRYTTLKEDYDRILATSVSAVWRHNYTGGEQERTPNWEKSYAQTKKHMLHA
                     FAETYSLSLQQTLYQMGSRVINSRPEIDEIRFSMPNKHHFRVDLSPFDMKNEAADGAVY
                     YAADRPYGLIEATVLRDGATPRIPVDMTNL"
ORIGIN
        1 gcattaccgt gcaggcccag atcgcccgca ccgaactggg cgtcacccag gtgaccatcc
       61 accccgccga cacccaggtc ggctccgcgg gctcgacctc cgcgtcccgg cagacgtaca
      121 tgacaggcgg cgccgtcaag cacgtgtgcg agctggtgcg cgagaaggtg ctccagcgcg
      181 gccgggagct gttcggcacc caccatccgg cgtgggcgac ggccggactg ctgctggagg
      241 gcggcaaggt cgtcaccgac ggcggcgagg tgctcgcctc gctggcggac gtgctcggtg
      301 aggaggccgt cgaggccgag gacgagtggc ggcaccgcac gaccgtgccc ttcgacctgg
      361 agacggggca gggcttcggc cacgtccagt actccttcgc cgcgcaccgc gccgtggtcg
      421 aggtcgacac cgagctcggg ctcgtcaagg tcgtcgagct ggcctgcgcc caggacgtcg
      481 gcaaggccat gaacccccag gccgtggtgg gccagatcca cggcggcacc acgcaggggc
      541 tcgggctggc cgtgatggag gagatcgtgg tcgaccctgc ggccaaggtc cgcaacccct
      601 ccttcaccga ctacctgatc cccacgattg cggacacgcc gaccatcccg gtcgacgtgc
      661 tggagctcgc cgacgagcac gccccgtacg ggctgcgggg agcgggggag gcgccgacgc
      721 tgtcgtcgac gcctgccgtg atggcggccg tcagggccgc gaccgggcgc gcgctgccgc
      781 gcgtgcccgt acgaccggag cacatcgtcc aggtgtgatc cttttccccg gccccgcccc
      841 ttcccggaac cgggggcccg gcccccaacc cccgctcctc aatcgccgga ggggctgctt
      901 ttgagcctgt ccggcgcttg aggacgagcg aagcgatcgg gggaaagggg ggcgaagccc
      961 ccatgagaaa cggtgaaggt gggggtcccc cggacggagt ctgggggagg ggctggggtc
     1021 taagcgccgg cgcgggccgt cccccgggtc gtggcttccc aaatcctcgg tatccgccgg
     1081 ggtgcccctg tgaaccttgg gagtcagcac aatgacccag tccaaagtag ggccgacgac
     1141 gtcgccggag gacgcgggcc ccggctcgcg catccccgcg ggacgctcgt ggctcgacag
     1201 gtacttccac atctccgcga gagggtcgag ttacggccag gaggtgcgcg gcggtatcac
     1261 caccttcatg gcgatggcgt acatcgtcct gctcaacccc gtcatcctct ccgtgcccga
     1321 cgccgcgggg cacaggctgg acggcggcga ggtcaccacg gcgaccgcgc tggcggccgc
     1381 ggtgaccacc ctcgtgatgg gcttcatcgg caacgtgccg ctggcgatgg cggcgggcct
     1441 cagcgtctcc gctgtcatgt ccacgcaggt agccaccgag atgacgtggg gcaacgcgtg
     1501 ggcgatgtgc gtcatctacg gcgccgtgat catcctcctg gtggtcaccg ggctccgtga
     1561 gctcatcatg aacgcgatac ccatggcact gaagcacgcc atcaccatgg gcatcgggct
     1621 gttcgtctgt ctgctcggcc tggtgcaggc cggcttcgtc acctccacgg gcggccccgg
     1681 aggtctgccc ggcgtcaagc cgatccagct cggcaccgcc gaggtgctca ccggctggcc
     1741 ggtgctgtgc ttctccgtga ccgtgctgct gatcttcgcg ctccaggtgc gcaaggtgcc
     1801 gggcgcgatc ctgatcggca tcgtcggcgg caccgtcatc gcggccgtca tccaccagtt
     1861 cgccgggctc accaagaagg actggggcgg ccacaacgcc cccgagttcc ccggttcggt
     1921 ggtcagctcg cccgacttcg ggctcttcgg ctccgtctcg ttcgacggcc tcggcgacgt
     1981 cggcgccatc tccatcggcg tcatcgtctt caccctcgtc ctggcgggct tcttcgacgc
     2041 catcggcacc atcatcggca tcggccagca ggccgggctc gccgacaagg agggccgcat
     2101 gccggggctg gccaaggcgc tgaccatcga cggcgccggc ggcgtcatgg gcggtctggc
     2161 cggtgcctcg gggcagaccg tcttcgtgga gtccaccgcc ggtgtcggcg acggcgcgcg
     2221 caccggcttc gccagcgtga tcagcggcct cggcttcacc ctctgcctgt tcttcacgcc
     2281 cctcgcgcag atgatccctc cgcaggtggc ggcggccgcg ctggtcgtca tcggatcgat
     2341 gatgatcacc aacgccatgc acatcgactg gtcggacccg gccacgtcga tcccggtctt
     2401 cctgacgacc gttctgatgc ctttcgcgta ctcgatcacc accggtatcg gcgcgggcgt
     2461 catctcctat gttctgatca aggctgtaca gggaaagttc cgcgagcccg gatggttgat
     2521 gtgggtgctg ggattcgtct tcctggccta tttcgcgctc aacccgatcg agcagtggct
     2581 gggggcgaaa tagccgcccg gccgccggcc tgacgcccgg cgggagcggg tgcggtcgcc
     2641 ctggccgttc ccgctcccgt tcaggctgct cggacctgcg ccaacgccga ggagtaggca
     2701 catgctggac atcgccgcac agctgcaccg ctggtgcgag gaaggacgcg acttcgccgt
     2761 cgccaccgtc gtcggcgtca gcaacagcgc cccgcggcag gtcggcgcgg cactggccgt
     2821 cgacgcggac ggcgaggccg tcggcagcgt gagcggcggc tgcgtcgaag gcgccgtcta
     2881 cgagctgtgc caggaggcgc tggagtgcgg cgacagcatc cgccagacct tcggctacag
     2941 cgacgaggac gccttcgccg tcggcctcac ctgcgggggc atcatcgaca tcctggtcac
     3001 cccggcgcgc gccggaacgc gggcgcgcgc ggtgttcacc gccgccgtcg ccgaagccgc
     3061 ccagcgccgc accgccgcgc tcgtccgcct cgtggagggc cccgacgagc tgctgggcgg
     3121 cgcgctgtgg ctggacgccg aagggcagcc ccacggcgcc ctgggcggcg cggccgagct
     3181 ggacgccaca gccgtggcag agggccgggc cctgctggac gccggccgca ccgcgaccgt
     3241 caccgtcggc gccgacggca gcaggtgcgg agcgccggtg accctgctcg tcgagtcgag
     3301 cgtccccgcg ccccgcatgc tggtgttcgg cgccatcgac ttcgcggccg cgctggtgcg
     3361 gatcggcacg ttcctcggct accgggtcac cgtgtgcgac gcgcgccccg tcttcgccac
     3421 cgcccgccgc ttccccgacg ccgacgaggt cgtcgtcgac tggccgcacc gctacctcga
     3481 cacccaggag ctggacggcc gcaccgtcgt ctgcgtgctc acccacgacg ccaagttcga
     3541 cgtgccgctg ctggagcgcg cgctgcggct cccggtggcc tacgtcggtg ccatgggctc
     3601 gcgccgcgcc cacctggagc ggctggagcg gctgcgcgag gccgggctga ccgacgccga
     3661 actcgccagg ctgcgctcgc ccatcggcct cgacctcggc gccaggacgc cgcaggagac
     3721 ggcgctctcg atcgccgcgg agatcgtcgc ggtgcgccag ggcggcaccg gcgtgcccct
     3781 caacggcgcc cacaccccca tccaccacga ccggggcccg gcccccggct cgctcacggg
     3841 cggcacggac cgggcgacgg gctgaacccg ccgacggcgg acggtgctag ggagtgtctt
     3901 caaagtagcg gcgtccgccc ggagggcggg cctggcggtg tctggtgcgt gcgctcgcaa
     3961 ggcggaggag ggagtccctg cgtgggggca cctcccgggg cgagcgaagc cgagccctgg
     4021 gggaagcggc gaccgacgac aacgccgcga gcgtgcgtgc caggcgccgc caggcaggcg
     4081 ggactttgaa gacacgacct agagcagttt cacgttcacc agcagcgccc ggtggtccgt
     4141 gccccgcagg tcgaggaact tgccgtccac cggcaccatc tcctcgctga gcagcacgtg
     4201 gtcgatctgc gcgcccagca ccggtgtggt gcgggtcggc cacgtcggtg tgcgcgagtt
     4261 gccgagcagg cgggccgcgt cgtgcatgcc ggtgtccagg acggcccgga atccggcgtg
     4321 gtcctgcgag gagttgaagt cgcccgcgat cagcgtcggc agcctgcggg ccgcggcgta
     4381 ggagcgcagc ccggccaact cggaccgcca cgtggccgtg tcgcctggcg tgggcggcat
     4441 cgggtgcgcc acctggaggg cgacccgctc gccgtggatg tcggcgacgg cgcccggcat
     4501 cgacagccgg ccgctcacct ggccccggtc gtgcagcggg tagacgctca gcagcgccga
     4561 gccccgcgcg ccgccgtcca ccccggtgac gagccggtgc gggtactcct cgcgcagcac
     4621 ggaaccgttc agcgccttcg cgcacgggtt gtcgcactcc tggacggcca ccagctgcgg
     4681 acgctccctg cgcaccgtct ccaccaggtc ccgcgtcgcc ccgccgtact tgaggttggc
     4741 cgtcagaacc cggaactgcg ccttgccggc caggcccgcg gccccgtccg gcgccggcgg
     4801 cccgtaagga cgcaggaacc agcccgtgcc cgccagaacc accagcgccc acaccagcac
     4861 cagccaccgc cgggccagcg ccgcgcccac cagcgccagc caggcgggca ccaggaacca
     4921 cggcaggaac gccagcagct gcggcaccgg ggtcggcccg tcctcgtccg ccgcgcggaa
     4981 acccaacggc acgctgagga cgaggagcgt cagcgcgcac agtgccgcga cgaaggggtg
     5041 ccggcgccgc cccgcgggcg caccgtccgc cactccccgc tccctgtccg tcctcgcccc
     5101 cgtgtacacg tccccgatga tgccgcacct cctgtcacgt tggggtaagc ccccgcccgg
     5161 gggtggtgcg cgcgcgggtg tacctccacg atgggctccc agcacttccg gcccccgctg
     5221 accaggaggg aacatgatcc cgtccacgcc caccgaggcc ttccgcgccg cccgcgacac
     5281 gctgctgacg caccggacgg actacgaggc cgcgcgcgcc gccttcacct ggccacggcc
     5341 cgagcacttc aactgggcgc tggactggtt cgaccggatc gccgagggca acgaccggct
     5401 cgccctgcac atcgtggagg aggacgccac cgagcggcgc gtcaccttcg cgcagatgcg
     5461 ggagcgctcg aaccgggtcg ccaactggct gcgcggccgc ggcgtcgtcc ccggtgaccg
     5521 cgtcatcgtc atgctgggca accaggtcga actctgggag accctgctgg ctctgatgaa
     5581 actgcgcgcc gtcgtcatcc ccgcgacccc gcagctgggc ccgcgcgacc tcaccgaccg
     5641 cgtcacgcgc ggcgaggccc gccacgtcgt ggcccgcgcc gcggacaccg gcaagttcgc
     5701 cgaggtggcc ggcgactaca cgcgcgtcgc cgtgggcagc ggcggcacgc ccgaggccgg
     5761 ctggctcgcc tacgaggacg cgtacgaggc cgacggcgcc ttcgacccgc ggggcgtcac
     5821 ccgcgcggac gacaccctgc tgctgtactt cacctcgggg acgaccgccc tgcccaaact
     5881 ggtggagcac acgcacgtct cctacccggt gggacacctt tcgaccatgt actggatcgg
     5941 gctgcgcccc ggcgacgtgc acctcaacat ctcctcgccg gggtgggcca agcacgcctg
     6001 gtccaacttc ttcgccccct ggaatgccga ggcgaccatc ttcatccaca actacacgcg
     6061 cttcgacgcg ggccgcctca tggccgagat ggaacgcggc ggcgtcacca gtttctgcgc
     6121 accgcccacc gtctggcgca tgctcatcca ggcagacctg ggcaagctcg cggccgtacc
     6181 gcgcgaggtc gtcgccgcgg gggagcccct caacccggaa gtcatcgaac acgtgcgccg
     6241 cgtctggggc gtgaccatcc gcgacggctt cggccagacc gagacggccg tccaggtcgc
     6301 caacaccccg ggccaggttc tcaagacagg atccatgggc cgccccaccc cgggcttcga
     6361 cgtcaccctc ctcgaccccg tcactggcga ggcgggtgtc gacgagggcg agatctgcct
     6421 cgacctcgcc gggtccccgg tcggcctgat gcggggctac cacggcgaca ccgagcgcac
     6481 cgagcgggcc atggcggacg gctactaccg caccggcgac atcggctcac gcgacgcgga
     6541 cggctacctc acctacgtgg gccgctccga cgacgtcttc aaggccagcg actacaagat
     6601 ctcccccttc gaggtggaga gcgtcctgct ggagcacgag gccgtcgccg aggcggccgt
     6661 cgtaccgtcg cccgatccgg tgcggctcgc ggtgccgaag gcgtacgtcg tgctggcgga
     6721 cggctacgcg gccgacgcgc agacggcgcg cgtgctgttc gcgcactgcc gcgagcggct
     6781 cgccccctac aagcgtgtgc gcgtcgtcga gttcgccgag ctccccaaga cgatctccgg
     6841 caagatccgc cgcgtcgaac tgcgcgcgca cgcggccggg gagacgggca cccccggggt
     6901 ggagcaccgc gacggctgag atccagtgcg ttctttcacg gtccggcccc cgcccccgat
     6961 cgcagcgatc gggggagggg gcggagcctc ccggaggaaa cggtggaagt ggggtcgctt
     7021 cagcggcgtg tgcgcagcag gtgctgggcc gcttcgttga tggcgctcgg tgttccggtg
     7081 aggtcgagga cgaacagcgg gagggcgagc gcctcggccc gggcccgcgc gtcgggcgcg
     7141 tacccggcaa gggcgaagca cacggcttcc acggagtcgt tgagcccggt gagccacagg
     7201 gtctccacct cgcgcacccc ggtcggcgtg gtggaggggt cgacgtgggc gacgacccgt
     7261 gcaccccgca cgtcgacccc cgaggccggg atccgctcgg cgacccgcac cccctcgaac
     7321 ccgagccacc gcaggtactg cgcggcggcg ttcttggcgt cgtgcgccgt gcggatggtg
     7381 acgggtctga acggcggccg taccaccggc gtcccgggcg cggcgggcgc cgccaccggg
     7441 ggcggcccgg tggtggcgcc ttcgcgcgcc ggggcgccgg cgcgggcgac cggcacccgc
     7501 agtgtggtgc cgcagccgca gcccaactcc ggctgcggcc actcgtcgac gcgcccgcac
     7561 gccgggcacc gtacggagat ccaggagccc gcccaggtgc ggtggcgcac ctgggtcgcg
     7621 gaggcggtgg cgagcagggg cagcgcgatc ggagcgccgc atccgcaggg gtacaccggg
     7681 gccgcgtagt ggtgctcgcg acggcacacg gggcagcgca caagcacact ttcagccatc
     7741 gttcgggctc cagcaggtcg tccggcactt cgccggtcac ggcacgattc cccccatcgt
     7801 gccccagccc cgccctgatc gtcaccggcc gttccggtcg ccggtgtcgc gcggtggggg
     7861 ccgctgtcgc gcggtgcccg ccgtgcggga ggatgacacg aggatgcccc cgcgcgggac
     7921 ggccacccct catcaactgg accgtcccgc acgggggcgc gcacggaccg acctcccaat
     7981 cggtcccgta cgccgctcat ggtgcggctg gcgcggagcg cgggtgctca gccctcctgc
     8041 agctcgcgga ccgcctcttc gacgcgcttg ccgtactccg gatccgcggc ggcgaagtgg
     8101 gcgatgttct tctcgacgac gtcctcgcgc gagacctgcg agaggccgcc ggcgatgttg
     8161 gcgaccagac ggttcttctc ctcctcggac atcagccggt agagctcgcc ggcctggaag
     8221 aagtcgtcgt ccttggtgtg ctgcggcgcc tcgtgggtgc cccagtggcc ggtcaccggc
     8281 tgcggcgcgg acagcggggc gccggtctcg acggggccgc cgtaggagtt gggctcgtag
     8341 ttcttggcgt ggcggtcgta ggcgttggtg gccatcaggc cgtcgcggcc gtagttgttg
     8401 gcgcccgtcg ccacggcctt cggcgcgttg accgcgagct gggtgtggtt gacgccgagc
     8461 cggtagcggt gcgcgtccgc gtaggcgaac agccggccct ggagcatctt gtccggcgag
     8521 gggccgatgc cgggcacgaa gttgttcggc gagaacgcgg actgctcgac ctcggcgaag
     8581 acgttgtccg ggttgcggtc cagcaccagg cggcccacgc ggatgagcgg gtggtccttg
     8641 tgcggccaga tcttggtcag gtcgaacggg ttgaagcggt agtcggccgc ctccgccgcg
     8701 ggcatgacct ggacgtacag cgtccaggac gggtagacgc cgcgctcgat cgactggagc
     8761 aggtcggtct ggtggctgtt ggggtcggag cccgacagct cggcgccctg ctcggcggac
     8821 aggcagcgga tgccctggtt cgtcttgaag tggtacttga cgaagaaggt ctcgccctcc
     8881 gcgttggtcc actggtaggt gtgcgagccg tagccgttca tgtggcggta ggaggccggg
     8941 atgccgcggt cgcccatcag ccaggtgacc tggtgggtcg cctcgggcga gttggcccag
     9001 aagtcccaga cgttgtcggg ctcctgcttg ccggtgaacg ggtcgcgctt ctgcgagtgg
     9061 atgaagtcgg ggaacttcag cggatccttg atgaagaaga ccggggtgtt gttgccgacg
     9121 aggtcgtagt tgccctcctc ggtgtagaac ttcagggcga agccgcgcgg gtcacgggcc
     9181 gcgtcggggc cgccgaggct gtcggcgacg gtggagaagc gggcgaacgt ctcggtgcgg
     9241 cggccgacct caccgaggaa gtgggcgctg gtgtaggcgc tgacgtcgtc cgtcacctcg
     9301 aagtagccgt acgcgccgga gccgcgggcg tgcaccacgc gctccgggat ccgctcccgg
     9361 ttgaaccgcg ccagcttctc cagcaggtgc tggtcctgga ggaggagcgg gccaccgatg
     9421 ccggcggagg tggagttctg gttgtcggcg acgggcgcac ccgcctcggt ggtcagcgtg
     9481 ggcttcgacg acttcgacat ggacgacctt cctggggcgt gtttcgcgga aaacagtttc
     9541 cgcatcatgg agcgtaggga ggcccgcagg gcgagtcaac agtttgttga aattttggcg
     9601 cgggggaaac ccgtaggacg gcgacacggc cggaaacccg ccgcttcccg ggtcttgtcc
     9661 gcccctgtcc gccgctcata tcgtcctcgg gtcgcgacgc acgcacgtgc tgaccgcacg
     9721 tgctcaaggg aacatgacgc tttcacggga gaaaccatgg aaacgctgtc agagttcacg
     9781 ccacgcgagg ccggggccct cccggcggag ccgcagacct ccttcgccga caccgacatg
     9841 agcaccgcgg cggcggaccg ctgcccgatc agcatgtgcg tcgaccactg cgtcggcacc
     9901 cagaccggct gaccgcacgg cccgcaggac cggcggcccc cgggccgccg ctgagcgccg
     9961 ctgactgctg agggaccaac gccttggggg agtcgggtcg atgacggact ggaacgcggt
    10021 ggacagcctg cgcgcgctcg tcgaggaacc ggctccccca gggcacccgg cggccacggg
    10081 ggaacacgtc gtcacccccg ggccacactg ggtgcacgtg cggccccacg aggcggaccc
    10141 gctgcccggc gagggctgga agctgcacat ctcctcccgg gccgccaccc tccccgcgct
    10201 cgccgaggtg ctgctgccca gactgctgcg ggagcggtgc cgcttcaagg tcgtgcgctc
    10261 cgcgcgggcg ctcgccctca tgaacgacgg acagcgcagc cccgcctcgg tcggcaaggc
    10321 cgtcacggtc tacccgtccg cagggcgcgt ccgcggcctc ggcctggagc tggccgcgct
    10381 gctgcgcggc cacgagggcc cccgggtgct cagcgaccgc cgggtcgccg ccgacgcacc
    10441 cgtctactac cggtacggcc ccttccgggc gcagtggcac gcgggggaca agggcaccct
    10501 cgtggtgcgg ctgcacggcg cggacggtga ggtcttcgac gcggccgcca ccctcgacta
    10561 ccggcagccg tcctgggccc gcgacccctt caagccggag gccggccccc gggacccggc
    10621 gcctgacgac cccgaccacg gcgaaggcgc ggccgaagcg ccgctgctgg gcgggcgcta
    10681 ccgggtgctg gagggcctgc gggagtcggc gcgcggcaac gtctaccgcg ccgaggacat
    10741 ccgcgccccc ggcccggccc acggctccgc gcgccccacg ctcgtcgtca agcaggcgcg
    10801 cgcctacgtg gccgagaacg cggacggtgt ggacgtccga gcgcggctgc gcaacgagcg
    10861 gcgggtgctg gagacctgcg ccggggtgcc cggcatcccc gccttcgtcg accacttcgc
    10921 gcacgaggcg gacgaatacc tggtcaccac ggacgccggg gacaccaacc tgctccgcca
    10981 catacgcggg aacggcgccc tgctgccgcc ggtccccgga gccggccccg gccgcggtct
    11041 cggccccggc ggcgagggaa gcgcggcgcg tgccgagcgc gagcggcgcg cggagcgctt
    11101 cgcccggctg tgcggcgacc tggccaccac cctcctggcg ctgcacgaga ggggcgtggt
    11161 catgcgggac atctcgccgc gcaacgtcgt cctgggcccg cgccgcgccc acctgatcga
    11221 cttcgggatc tcggcgctcg acggcctcca cctgcccggc ggcacccccg ggttcgcgcc
    11281 ccgcgagcag ctcgacaaga cggctgagcc ccgcccccag gacgaccact tcgcgctggg
    11341 catggtcctc gcctacgccg cgaccggact gctgcccgtg gtgggggccg ccaccacccg
    11401 gctggcacgc gagcggcaac tggcctgcct cgcggccgtc tacggcgaga gccgcgccgc
    11461 gctgcgggcc acgctggcgc agctgcaaag cggcgacgcg gacgccgggc gcagcgccct
    11521 gctggccctg gccacccagc caccggcaca agaacccgca ccggcggcgc ccccaccggc
    11581 gcccgccccc gcctccgcgc cccgcccggc agggccgccg tcccgcacgg cggggaccgc
    11641 gtcgcgcgca cacctggcgc aggcggtgcg ggaagcgctg ctggcgggcg tcgccgacta
    11701 ccagttcggc ggcgagtacg ccgacttccc cgccgtggac gcgagcctct acaccggcag
    11761 cgccggagtc ggcctcgaac tgctgcacca ccgggaggag cccggcgtcg ccaaggtcct
    11821 cgaccagctc gccgcgcacg cgcacgacgg gctgcgccgc gtcgcgctgc cacccgggct
    11881 cttctcgggg cgtaccggca ccgagctctt cctcgccggg gcgcgcgcgg ccggtgtggc
    11941 cgtacccgag gggccgctgc ccggcggcac cgagtggagc gcgccggagc ccgagacgga
    12001 cgtgatcagc ggccgtgccg gagtggggct ggcggcgctg tcgctgggcg acctggacgc
    12061 ggcgcgcgaa caggccgggc gcctggccgc gctgccgccc cgcaccgcgc cgcgggacga
    12121 ggacgacgcg agcggcagcg accccggatt cggctacgcg cacgggttcg ccgggacgac
    12181 cgacctcctg ctgctcgtcg cggcgcgcac gcccgacgac tcggctctgc tgagcgccgc
    12241 gcacgcccac gcgcgcgaac tggcccgccg cacggtccag ctggccgctg cctcgcgcgg
    12301 ccccgaggcc ctgccgatgg tggcctcctg gtgccgcggc ctggcgggcg ccgcccgcac
    12361 gctccagcac gcccgcgaac tcttcgccgg cgaaactgac ttcgccccgg ccgccgaaca
    12421 ggccgcgctg gccgccgccg agtgggtgcc gcgcatggag acgccgggcc agtgctgcgg
    12481 cgccagcggc gtgggcacca tgctggtgga gctggcgcgg gcgaccggag acggccgctg
    12541 gctggaggcc gcgcacgagg tggcggacca tctgctgcgg cgcagcctcg gccccgacga
    12601 ggcgcccgcc ctgctgaaca ccgagctcca ggagaccccg tactcctggg cgcagggcta
    12661 cgccgggatc ctcaccttcc tgcgccgcct ggagcacccg gacagccccg gcgtgctcgg
    12721 ccccgctgcc tcggagtgag ggagcggggc cggcggcgca cagaggaggg gcgggcgggc
    12781 cgcccgggcc tcagcccagc ggcaccgtgg ccgtcggcgc gtgggacgcc tcggtggcca
    12841 gctcctcgaa ctcgttgacc gagccgatgt cgctcccgct catcgagatg ttggtgatcc
    12901 gctccaggat cgcctccacc acgaccggca cccggtgctc ggcggcgatc ttcttcgcct
    12961 cctcgaaggc gggcagcagc ttgtccggct cggtgacgcg gatcgccttg cagcccaggc
    13021 cctcggcgac cttgacgtgg tcgacgccgt aggcgcccag ctccggggtg ttgatgttct
    13081 cgaactccag gttgacctgg aagtccatgt cgaacccgcg ctgcgcctgg cggatcaggc
    13141 ccaggtagga gttgttgacc agcacgtgca cgtaggggat gtggtgctgc gcgccgacgg
    13201 ccagctcctc gatcatgaac tggaagtcgt agtcgcccga cagcgcgacg acgctcgcct
    13261 ccgggtccgc cttggcgaca ccgagggcgg ccggcaccgt ccagcccagc gggcccgcct
    13321 ggccgcagtt gatccagtgc cgcggccggt agacgtgcag gaactgcgcg cccgcgatct
    13381 gcgagaggcc gatggtggac acgtagcggg tctcgggccc gaaggcgcgg ttcatctcct
    13441 cgtagacgcg ctgcggcttg agcggcacgt tgtcgaagtg cgtgcggcgt tgcagctcgc
    13501 ccttgcgccg gcgggtggtg tccgcccact tggacaggtc cttgagctgc ccggcggcct
    13561 tgcgctcctt ggcgacctcg acgaagaggg tcagtgcggc gtgcgcgtcg gagacgatgc
    13621 cgtagtccgg tgcgaagatc ttgccgatct gggtcggctc gatgtccacg tggacgaagg
    13681 tgcggccctc ggtgtaggcg tccagcgcgc cggtgtggcg gttggcccag cggttgccga
    13741 tgcccaggac gaagtccgac tccaggaagg tggagttgcc gtacctgtgc gaggtctgga
    13801 ggccgaccat cccggcgtgc agcgcgtggt cgtcgccgat cgcgccccag cccatcaggg
    13861 tcggcacgac ggggacgccg gtcagctcgg cgaactcgac cagcaggtgg gccgcgtcgg
    13921 cgttgatgat gccgccgccc gccacgatca gcggccggtc ggcctcggcc agcatgtcca
    13981 gggccttgag aacttgcttg cgggtcgcgg ccggcctgtg cggcaccagc ggctcgtagg
    14041 tgtcgacgtc gaactcgatc tcggtctgct ggacgtcgat cggcaggtcg atcaggaccg
    14101 gtcctgggcg gcccgagcgc atcaggtgga acgcctcctg gaagacgccc ggaacctgcg
    14161 ctgcctcctt gacggtggtg gccttcttgg tgaccggggc ggcgatggag gcgatgtcga
    14221 cggcctggaa gtcctccttc tcgatcaccg cgaccggcgc ctggcccgtg atgcacagga
    14281 tcgggatgga gtcaccgagc gccgagtaga ggccggtgat catgtcggtg ccggccgggc
    14341 ccgaggtgcc gatgcacacc ccgatgttgc cgggcgcggt acgggtgtag ccctcggcca
    14401 tgtgcgaggc gccctcgacg tggcgggcga gcgtgtgctc gacgccgccg gcggcgcgca
    14461 gggcggcgta gaacgggttg atcgccgccc ccggcacgcc gaacgcgacc tccacaccct
    14521 cacgcttgag gatctcaact gccgcacggg cagcggtcat acgagccatc gaactctcct
    14581 ggttcggtgc aggtggtacc cggacggcgg cgcctgggcg cgacaggaca gtgtcgacgc
    14641 cgccgcccgg agtcggtggg tgtaagcccg caggtcagga accgggaggg gtgtccgggg
    14701 tgacccgggt ggggcgtttc tcagttggcg ccgtcggggt tctcgcccga cagccgcttg
    14761 acgctgcgca ccagcgccga gtggtcgagc ccgccgtcgc cctgcgcacg cagcgaggcg
    14821 acgagctggg cgaccagcgc accggccggt acggcggcgc cgacggcgcg ggccgcgtcg
    14881 gtcacgatgc ccatgtcctt gtggtgcagg tcgatcttga agccgggctg gtagtcgccg
    14941 gccaggatgc tgtccttctt gcgggtcagc acggtggagc ccgccaggcc gccgttgagc
    15001 acgtcgagcg ccgcgttcag gtccacgccg gacttcttga ggaagaccac ggcctcggcc
    15061 acggcctcga tgttgacggc gacgatcagc tggttggccg ccttgacggt ctggccggag
    15121 ccggccgggc cgcacagcac gatcgtcttg ccgagggcct cgaggatcgg cttcgccgcg
    15181 tcgaagtcct cctgctcgcc gccgaccatg atggagagca cggcctcgat cgcgcccgcc
    15241 tcgccgccgg agaccggggc gtcgagggcg cgcaccccct tggccttggc ggccgcggcg
    15301 acctcgatgg aggtctgcgg ggtgatcgag gacatgtcga tgatcaggcc gccctcgcgg
    15361 atgttctcca ggacgccacc ctcgtgcagg acgacggcct cgacctgcgg ggaggccgga
    15421 accatcgtga tcacgacgtc ggcgtcctcg acggcctccg cgatggagga ggcgcccttg
    15481 ccgccgtcct tggcgaactg ctcgaccttc tcggtctcca gtgtgtacgc cgtgacgtcg
    15541 tagcccgcct tgagcagatt gcgggccatg gggtcgccca tgatgcccag accgatgaag
    15601 ccgatcttgg tgttgccggc cgtgtgagcc atgactgctt gcctttccca gatcctgtcg
    15661 ttgcccgccc cgcgcacggg gcactgcccc ggaccgcgtc cgggggaggg tgattacttg
    15721 ccgagccagc cgaaggaggc cgcgctgccg ttgtcgcccg gcttgtactc cagcccgatc
    15781 agaccgtcgt agccggcctt gtccagccgg ccgatgaggt cgtcgaagtc gagggagccg
    15841 gtacccggcg cgccgcggcc cgggttgtcg gcgatctgta cgtgcccggt cttggcggcg
    15901 tagcgctcga tgacgcccgc caggtcctcg ccgttcatgg acaggtggta gaggtccatg
    15961 aggaaccgcg cgttgcccag cccggtcgcc tcgttcacct tgtcgacgac ctcgatcgcc
    16021 ttcggggcgc tcaccagcgg gcacttgggc gactcgggcg cgttgagcgc ctcgatcagc
    16081 aggacgccgc ccacccggtc cgcctcccgc gcggccagct ggaggttctc cagcgcgagt
    16141 gcgtcctgct cctgctcggt gacgccctcg acgcggttgc cgtagagggc gttgaacgcc
    16201 ttgcagccca gcgaccgggc gaagtccgcg gccaccttca ggttggcgcg gaacctctcc
    16261 gactcctggc cggggatgga cagggcgccc ctgtccgggc cggggagctg tcccgcgtag
    16321 aagttcagcc cggtgagctg gacgcccgcg tcctcgatgg cgctgcgcag cgcgtcgagt
    16381 gcggagcgct cgggcacggg ggcgtcgacc cacggccacc acagctcgat cttgtcgaac
    16441 cccgcggcgg cggccgccgc cgggcgctcc agcaggggca gctcggtgaa gaggatcgag
    16501 gcgttgacgg tgaaccggtc cgaggagacc actgcgaccg cccttccttc cttgggggtt
    16561 tcgtccggtg agcgcgtcga gtaattccgt attgtgaaac tcgtattctg ctcactggaa
    16621 gattgctctc cgggcggccc tcctgtcaag agccgcaggc ggtcgcggac agcgaagagc
    16681 cccgggctcc gccggaatga cggagcccgg ggctcgatgt gcaagcgctg ccgacgcgcc
    16741 tgttcagggc ttgcgggcga cccccgccca catgctcacc agcgcgtccg tggcgtcccc
    16801 cggatcgtgc ggaggcaggt tcacgacctg cgaggtgtcc tggtccgggt gccagcggtg
    16861 cggcacctcg atacccggct cgacgaggtc gagcccctcg aagaagcggg cgaactcctc
    16921 cttcggccgc acctgggcgc tgcccccgtc catcttgtag acctccatgg cctgctccca
    16981 ctcctcgggc gcgaagtccg gggtgcactg ggagaggacg acgtagctgc cggcgggtat
    17041 cgcctcgacc agatgccgga cgatgccgtg cgcgtcgtgc tcgtcggtga tgtagtgcag
    17101 cagccccacc agacacagcg cgaccggccg gtcgaggtcg agcgtctcgc gcacctgcgc
    17161 ggagtgcagg atgctgtcag gccgggtgat gtccgcgtcc acgtacgccg tgcgcccctc
    17221 ggccgagccg gtcagcaggg cgcgggcgtg cgcgagcacg atcggatcgt tgtccgcgta
    17281 gacgacgcgc gcccgcggcg ccatcgcctg caccacctcg tgcaggttgg ggctggtggg
    17341 gatgccggtg ccgatgtcca ggaactggtg gatgccgcgc tcggccagga accgcgcggc
    17401 gcggtgcatg aaggcgcggt tggcgcgggc ggcgttgcgg aacccgggga aggctgccag
    17461 cagcttctcg gccacttccc ggtccggcgg gaagttggtc ttgccgccca ggaagtagtc
    17521 gtagatgcgg gcgctgtggt gccggtcgag gcccaggtcg cgctcgctgt gcggtggcct
    17581 ggcggcacgc tccgtccgcc gtcgccgctc gccgttccgg tccatgtgtc tgcccctgtc
    17641 gtcgcctgag ctgtgggcgg catcgtagtg gccccaggtg tgccgagcgc tccattctgc
    17701 gacaccaact gccgtgtctc gaagggtggt tgcgtggtgc tccgggaggg ggtatggggg
    17761 cgccccggcg gacacgggca cgccggggcg cgtattctcc cggtgcctgt accggaccgg
    17821 tgctcaggtg ccacactgtt gtgaccgccc agtcaccctt gggagtcgga atgtccgcca
    17881 tgatgcagcc gtcaggggcg ccgtcgcgtg ggggcgcgtc agaagcgccg aacggcccca
    17941 ccgcgctgcg catcatcctg ggtgtcaagc tgcgcaggtt gcggcaggcg ctggacatct
    18001 cccgggagga cgcgggccgc gccatccgcg gctcccacgc caagatcacc cggctggagc
    18061 gcggtcaggt cggcgccaag gaacgcgacc tgcgggatct gctgacgctc tacggcctcc
    18121 acgaccggga ggagcgtgag gagttcttcg acctcgcccg ccaggccaac tcgccgggct
    18181 ggtggtacca gtactcggac gtgctggagg actggttcga gctgcacctc ggcctggagg
    18241 acgcggcctc cctgatcagg acgtacgagg tccagttcct gccggggctg ttgcagaccg
    18301 aggagtacgc gcacgccgtc agccgcctcg gctaccccaa caccgagccg cgcaaggtcg
    18361 cgcggatcgt ggatctgcgc atggcccgcc agaagctgct gcaccgctcg gatccgccgc
    18421 gcctgtgggc cgtggtcgac gaggccgtgg tccgtcggcc gttcggcggc gccgaggtga
    18481 tgcgggcgca gctcgaacac ctgctgaagg tcgtgcggct gccgcacgtc actctccagg
    18541 tcgcgccctt cgaggtgacc gcggcggcgg ccggcacgcc ggtgacgctg ctcaggttcg
    18601 ccgacccgga cctgcccgac aaggtctatc tggagcacct gaccaacgcg gtctacctcg
    18661 acaagcccgc cgagatcgac cagtacacgc tgatcatgga ccggctgtgc gccgaggcgt
    18721 tctcgccgaa ggagacggtc tccttcatcg aggagctcct ggaggagctg cactgagcag
    18781 cccggggcgc ggtgccctcg gtagtgtgtg gcgcatggaa cgcttgcgtg tggagttcac
    18841 gaccgagcct ttcgacctcg acgaggctcc tcggcacgct gtcgtggccc gggaggtcgt
    18901 ccagggtgcg gcactggatg ccgtggacgt cggccccttc ggcaacaccg ccgagggctc
    18961 gggcgaacag gtgctggcgg ccgtgaccga gctgctgcgc cgctcgctgg aggcgggggc
    19021 gacccgggtc tccctccagg tcaacgtgat cggggaggac gagggctgat gggggacgag
    19081 ccgcacgccg cccgccatcc gttcgtcgtg gcggtcaagc cgctggtcga cgccatggga
    19141 ggggcgatgg tggagccgga acaggcgcag ggggacgacg tggtcctcgc ctgggagggc
    19201 gaggacgtgg tggctgtacg gctgccgcac ctgtccgact ccctcgacca cctcctggcc
    19261 gaactggaga ggcggcacgg ggtgccgctc gcggagctgg accgcaggag caagcagtcg
    19321 gtggtccgga tcctggagac gcggggagcg ttctcggtcc ggcacggggt ggagacggtg
    19381 gccggcgccc tgggcgtttc ccgcttcacc gtctacaact acctgaaccg ggacgacagc
    19441 cgctcggact gagggtctcc ggcgccgcgc cgggaaccgc gaaggaaagc ccgccatgct
    19501 tccgcatggc gggctttcgt ttccaagatg tcgaaaaggc ttcaacaaac tgttgacgtg
    19561 gtgttgccgg gggacttagc tgttcccagc ccgaacagca ccacggccac ggagggtccc
    19621 gtgacttcgc gttcgacgcc aggtctcacc tggttcaaca ccgccaagga cgccgaggcg
    19681 cgcgccgcgc tccacgacgt gtgcgccgca ggaagctggg ggagcgcgct gctctcccag
    19741 cgaccgtacg acagcgccga ggctctcttc gcggcgagtg acgaggccac cggggccctc
    19801 accgacgagg gcctcgacga ggccatggcc gggcacccgc ccatcggccg cccgaagccc
    19861 ggcgacccga cctcggcccg cgaacagcgg agcatggccg gcgcctccga ggcactgaag
    19921 gccgagatgc tcgaactcaa cctggcctac caggacaagt tcgggcacgt gttcctcatc
    19981 tgcgccaccg gcaagaccgc cgaggagatg agggacgccg ttcgtcaccg gatcgacaac
    20041 tccccccggc aggagaggga gatcgtgcgg cgggaactgg cgaagatcaa ccgtcttcga
    20101 ctcacccgcc tcacggagga aggagccccc acggcatgag cgacgcgacg agtacctcgg
    20161 tgtccacgca catcctggac accagcctcg gccgcccggc cgcggaggtc ggtgtacggc
    20221 tcttcgtacg ccagggtgac ggacaggccg catgggccgc gcacggggcg tcgaaaaccg
    20281 acgccgacgg gcgctgcaag gactttccgg cgctgccgga aggcaccacg cacgtacgga
    20341 tcgtcttcga gacggagccg tacttcgcgc aacagcacag ttcgaatccg cgcagccagc
    20401 gcgaagccgc ggaacagcag gacgcccccc gcgtaaggga cagcgcacca ggcagcttct
    20461 ttcccgaggt caccatcgtg ttcgcggtcg acccgggcga gcactaccac gtgccgctgc
    20521 tgctcaaccc gttcggctac tccgtgtacc gagggagctg acacctatgc ccacgattct
    20581 cggccagaac cagtacggca aggcggagaa ccgcgtcgtc aagatcacgc gggacggcga
    20641 cacccaccac atcaaggacc tgaacgtctc ggtcgccctc agcggcgacc tggacgacgt
    20701 gcactactcc ggctccaacg cccacgtcct gccgaccgac accaccaaga acaccgtgtt
    20761 cgcctacgcc aaggagcacg gcatcgagtc ggccgaggcg ttcggcctcc tgctggcccg
    20821 gcacttcgtc gacgacaccg agccgatcca ccaggcccgt atccgcattg aggagtacga
    20881 gtgggagcgc atcgagacct ccgacgccaa ctccaggttc atcggcgccg acgaggtcaa
    20941 gcactccttt gtccgcaagg gccaggagac ccgcaccgcg cagatcacct acgacggtga
    21001 gggcgtcgag gtgctctccg ggctgaagga cctgaccgtg ctcaactcca ccaactcgga
    21061 gttctggggc tacatcaagg accgctacac cacgctgaag gaggactacg accgcatcct
    21121 ggccacctcg gtcagcgccg tgtggcggca caactacaca ggtggcgagc aggagcggac
    21181 gcccaactgg gagaagtcct acgcccagac gaagaagcac atgctgcacg ccttcgccga
    21241 gacctactcg ctctcgctcc agcagaccct ctaccagatg ggttcgcgcg tcatcaacag
    21301 ccggcccgag atagacgaga tccgtttctc gatgccgaac aagcaccact tccgcgtcga
    21361 cctgtcgccg ttcgacatga agaacgaggc ggcggacggg gcggtctact acgcagcgga
    21421 caggccctac ggcctgatcg aggcgacggt cctccgcgac ggtgccaccc ctcgcatccc
    21481 cgtggacatg accaacctct gatccacccc tgcctgcccc ttcccacctt ccgggggacc
    21541 gttcacggcc ccggactccc tcggcgggcc cgcttgtcgc gcgggcccgc ccgggagggc
    21601 ggtccgttcc ctgcggaccg cggggcccgg gacggaacct ccgcgaggag acgggaagag
    21661 ccctggcggg gccgtaaacc ccccgaacga ggaccccatg gcggaccaac aagccgcggc
    21721 taccggccgc atcgtcatcg agaagtgtgc gatcgcgacg gtcgacgcgg aagataccga
    21781 gtacgcgacc ggtcacgtcg tcatcaacgg caaccggatc gagtcggtcg gtccgggtga
    21841 cgcgcccggc ggcttgcgac acgtcacgcg ccgcgtcgac ggcacgggac acctgctcac
    21901 cccagggctg gtcaacaccc accaccactt ctaccagtgg atcacccgtg gtctggccac
    21961 ggactccaac ctcttcgact ggctggtcgc cctctacccc acgtgggcac ggctcgacga
    22021 ggagatggtg tacgcggcgg cccgcggctc gctggggatg atggcccgcg gcggtgtcac
    22081 caccgcgatg gaccaccact acgtcttccc gcgcggcgcc ggagacctgc tgggcgccga
    22141 gatacgcgcg gccggcgagc tcggcgtccg cttcaccgcg gcccgcggat ccatggaccg
    22201 cggcacctcg gacggcggac tgccgccgga cttcgccgtc gagacgctgg acggcgcgct
    22261 ggcggagacc gagagggcca tcgacgccca ccacgacgcc tcgttcggtt cgatgctgca
    22321 cgtcgccgtg gcgccgtgct ccccgttctc cgtgtccacc gagctgatgc ggcagggggc
    22381 cgagctggcc cgccgcaagg gcgtgcgcct gcacacgcac ggctcggaga cggcacagga
    22441 ggagaagttc tgccacgagc tgttcggcat gggcccgacc gactacttcg agtcggtcgg
    22501 ctggctgggc gaggacgtgt ggatggcgca ctgcgtccac atgaccgacg cggacatcga
    22561 ggcgttcggc cgtacgaaga cgggtgccgc ccactgccct tcgtccaacg cgcgggtggc
    22621 cgcggggacg gcgcgggtgc ccgacatgct cgcggcgggc atccccgtgg gcctcggcgt
    22681 ggacggtacg gcctccaacg agtcgggcga gctgcacacc gagttgcgca acgcgctgc
//
