LOCUS       NZ_KZ845881            20729 bp    DNA     linear   CON 11-APR-2024
DEFINITION  Enterococcus faecalis strain 262EA1 aekev-supercont1.1, whole genome
            shotgun sequence.
ACCESSION   NZ_KZ845881
VERSION     NZ_KZ845881.1
KEYWORDS    WGS; RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 2403193)
  AUTHORS   Earl,A.M., Van Tyne,D., Lebreton,F., Saavedra,J.T., Gilmore,M.S.,
            Manson Mcguire,A., Clock,S., Crupain,M., Rangan,U., Young,S.,
            Abouelleil,A., Cao,P., Chapman,S.B., Griggs,A., Priest,M., Shea,T.,
            Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genomics Platform, The Broad Institute Genome
            Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Enterococcus faecalis 262EA1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2403193)
  AUTHORS   Earl,A.M., Van Tyne,D., Lebreton,F., Saavedra,J.T., Gilmore,M.S.,
            Manson Mcguire,A., Clock,S., Crupain,M., Rangan,U., Young,S.,
            Abouelleil,A., Cao,P., Chapman,S.B., Griggs,A., Priest,M., Shea,T.,
            Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genomics Platform, The Broad Institute Genome
            Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JUN-2015) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R48559
            Genome Coverage                   :: 131.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003319555.1-RS_2024_04_11
            Annotation Date                   :: 04/11/2024 13:29:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,976
            CDSs (total)                      :: 2,907
            Genes (coding)                    :: 2,847
            CDSs (with protein)               :: 2,847
            Genes (RNA)                       :: 69
            rRNAs                             :: 3, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 4, 3 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 40 of 60
            Pseudo Genes (incomplete)         :: 25 of 60
            Pseudo Genes (internal stop)      :: 25 of 60
            Pseudo Genes (multiple problems)  :: 25 of 60
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:38:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 716561
            Orig. end                         :: 737290
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ845881.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Please be aware that the annotation is done automatically with
            little or no manual curation.
FEATURES             Location/Qualifiers
     region          1..20729
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="2"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20729
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20729
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10729](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10729)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    107..122
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: strong, score: 28.99"
                     /tool="antismash"
     misc_feature    578..592
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.08"
                     /tool="antismash"
     gene            complement(1997..3385)
                     /locus_tag="EB41_RS03625"
                     /old_locus_tag="EB41_00701"
     CDS             complement(1997..3385)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010712556.1"
                     /locus_tag="EB41_RS03625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00701"
                     /product="MFS transporter"
                     /protein_id="WP_256891523.1"
                     /transl_table=11
                     /translation="MIDRKKVILYTCCMSLFVVTMDVTVVNVALPSIQSDFHTNLSTLQ
                     WVTDGYTLMVASLLLLSGSTADRIGRKRVLQLGLACFGLASFLCGISQTPGQLIAFRML
                     QGIGGSMLNPVAMSIITQVFTEKLERAKAIGLWGSVTGISLGMGPIIGGLIVSYFSWRY
                     VFFVNVPIIAAAIILTQKFVPESKVEKTVKNDFVGQALMILFLFSSIYSIIGLPRKGLF
                     APDILSTGIIGCLAIVIFFIYEYNIDNPLINPRFFLSIPFTSASFLAIFGFIIYNGYLF
                     LNTLYLQEMRGFSPLEAGLSTIPLAFVSFLVAPRAGEMVGRIGTKRPIMLCGISMLAVS
                     FLQLFVTKTTPMIILFVIYIFLGIGFGMLNSPITITAIEGMPFSQSGTAAAIAVTCKQI
                     GNSLGVALPSLLITKPITSSLTRTPFTNVWLLFGCCAIAIIFLSYLSNSPLAKKSLRRV
                     RFYF"
     gene            complement(3767..4621)
                     /locus_tag="EB41_RS03630"
                     /old_locus_tag="EB41_00702"
     CDS             complement(3767..4621)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010821679.1"
                     /locus_tag="EB41_RS03630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00702"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_002408854.1"
                     /transl_table=11
                     /translation="MTIEKLEYFYTIAKYNSISKAASELHVSKSTLSASLKDLESELGH
                     LLFDRNGNSLTLNSYGDKIVQSVYIILNEAKKMKLNLHEMIENPVMRLGFGNTSLMYKV
                     TENEDQLNRFWECYHGSSFELLNKLENHELDFVITSADVNSPVLKKEQLIELKMYLCVS
                     REIKQEIEEEGFICLTNYPFLFLPHHLDHLEATKSVLEMLQLTSPLVCCYDTLMLTRLI
                     EKSKGVYAVISLRKEQLQEIDSKLFFLPIERKQKFYLYRNVSSSVFVQPGQIKATLQKL
                     LET"
     gene            5013..5843
                     /locus_tag="EB41_RS03635"
                     /old_locus_tag="EB41_00703"
     CDS             5013..5843
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002397393.1"
                     /locus_tag="EB41_RS03635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00703"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_002357232.1"
                     /transl_table=11
                     /translation="MKINYLGTGAAERIPGIFCNCKLCKYAREKKGREIRTQTQLIIDD
                     VLLIDFPGDSYLHLLQYDLCFADFDSLLISHWHSDHFYGEDLAYRMSGYALDIPNRLTV
                     YGNEAVKTFYQRAFDLEGRQDDTRLHYQVIQPYKCFTIANYTIYPLPAQHGNFSEDCFI
                     FVIDDGKDAFLSTHDTGYFTSEMFEYLEKSHLLLSIVSLDCTSQTNETGNSHMNWEENL
                     KLITELKERKLVTDKTIYVANHFSHNGGLSYAEMAALSQKHEIITSYDGLEILT"
     gene            complement(5991..6845)
                     /gene="sprE"
                     /locus_tag="EB41_RS03640"
                     /old_locus_tag="EB41_00704"
     CDS             complement(5991..6845)
                     /codon_start=1
                     /gene="sprE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002364098.1"
                     /locus_tag="EB41_RS03640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00704"
                     /product="serine proteinase SprE"
                     /protein_id="WP_002357230.1"
                     /transl_table=11
                     /translation="MKKFSIRKISAGFLFLILVTLIAGFSLSANAEEYIVPAESHSRQK
                     RSLLDPEDRRQEVADTTEAPFASIGRIISPASKPGYISLGTGFVVGTNTIVTNNHVAES
                     FKNAKVLNPNAKDDAWFYPGRDGSATPFGKFKVIDVAFSPNADIAVVTVSKQNDRPDGP
                     ELGEILTPFVLKKFESSDTHVTISGYPGEKNHTQWSHENDLFTSNFTDLENPLLFYDID
                     TTGGQSGSPIYNAQFEVVGVHSNGGIKQTGNHGQRLNEVNYNFIVNRVNEEENKRLSAV
                     PAA"
     gene            complement(6894..8426)
                     /gene="gelE"
                     /locus_tag="EB41_RS03645"
                     /old_locus_tag="EB41_00705"
     CDS             complement(6894..8426)
                     /EC_number="3.4.24.30"
                     /codon_start=1
                     /gene="gelE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002369251.1"
                     /locus_tag="EB41_RS03645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00705"
                     /product="M4 family metallopeptidase coccolysin"
                     /protein_id="WP_002357227.1"
                     /transl_table=11
                     /translation="MMKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLS
                     KLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDKNGAVTSV
                     TGNPVDQVVKIQSVDAIGEEGVKKIIASDNPENKDLVFLAIDKRVNNEGQLFYKVRVTS
                     SPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVTFNVPVEKSNTGIALHG
                     TDNTGVYHAVVDGKNNYSIIQAPSLATLNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRG
                     MPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAG
                     LEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMA
                     QYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQ
                     FSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDIQVNQPSESVLVNE"
     gene            complement(8661..10004)
                     /gene="fsrC"
                     /locus_tag="EB41_RS03650"
                     /old_locus_tag="EB41_00706"
     CDS             complement(8661..10004)
                     /codon_start=1
                     /gene="fsrC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002402207.1"
                     /locus_tag="EB41_RS03650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00706"
                     /product="sensor histidine kinase FsrC"
                     /protein_id="WP_010715283.1"
                     /transl_table=11
                     /translation="MILSLLATNVLLVSSFIVFVFLRVTLIKIECKIPLLSLLIVINLC
                     SFAALMLGYSWLIYALTVVVFTGFLLIHKKRFSIFKAIFLSVFTLLMVSFINYTEQTIL
                     SVFFQQIYQNKLLWIASNVLLLLINIWIALKIPNSVFLRLNRVLENSRIFFGCLLLLLI
                     LLLLFVFLISPEISPDFMRGFVTVNSSKLELLISVGLFLILIGLVIEAYLEEQRINTQL
                     LNNLTIYTEKIESINEELAMFRHDYKNLLYSLQIAISYEDILEIKRIYEETIAPTKKII
                     DNEEFELMKLNRLKNMELKALISMKINTAKQAKLKVIVDVPEVFILDTSIDLVVVIRLL
                     AILLDNAIENSAKSELKMFAISIFNKNETQEFVITNSVQAEFDFRVMKKTKFSSKSNPE
                     EHGWGLLYVKEIVDFSDQFDLQTSFNEGSVTQHLIIEKNHNSKKVVNE"
     gene            complement(10001..10729)
                     /locus_tag="EB41_RS03655"
                     /old_locus_tag="EB41_00707"
     CDS             complement(10001..10729)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016634271.1"
                     /locus_tag="EB41_RS03655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00707"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_016614687.1"
                     /sec_met_domain="AgrB (E-value: 4.5e-31, bitscore: 104.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIDWILKNIMDMDQEDQSGKTQWTKYYLTVYFSGLFNFLMILIL
                     SVLFGTLSETFIVYVILIFLRPVAGGWHAKTKWLCRLESIVIYVAIPFVLKNSSVSLPF
                     IYKILSMCLLVVLFYWYAPQGTAIEPVQPSDLNVLKKQSLIRVCLLILCSLFVKEKIAS
                     VILYGLVIQGLMILPVTKNLIEGSVFMKFGKKIIKNVIEKRVAKVSDGVGTKPRLNQNS
                     PNIFGQWMGQTEKPKKNIEK"
     gene            complement(10818..11549)
                     /gene="fsrA"
                     /locus_tag="EB41_RS03660"
                     /old_locus_tag="EB41_00708"
     CDS             complement(10818..11549)
                     /codon_start=1
                     /gene="fsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109506.1"
                     /locus_tag="EB41_RS03660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00708"
                     /product="response regulator FsrA"
                     /protein_id="WP_078126945.1"
                     /transl_table=11
                     /translation="MAIYILEDQIIQAKALEALLTNILHSRNIYNETIHLFSRSDELLQ
                     VAHQDAQLNIFFLDIQMNNHIQAGFEVAKEIRKTDSESLIVFISTHTELVLTSYKYMVS
                     ALQFIQKNVDFLDFQKEVETCVDAYIQQKENIKTKSEYIIINLKASSIKMDINDIYFFQ
                     TEYDHRVSMVGKNFKREFYGTLSKIEQLHPDLIRVHQSIIINKKYASKLNYKTHLLTMR
                     DGTEVPVSRRYYTQVKALFLT"
     misc_feature    11661..11676
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            complement(11968..13926)
                     /locus_tag="EB41_RS03665"
                     /old_locus_tag="EB41_00709"
     CDS             complement(11968..13926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401391.1"
                     /locus_tag="EB41_RS03665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00709"
                     /product="amidase domain-containing protein"
                     /protein_id="WP_016614688.1"
                     /transl_table=11
                     /translation="MKRKKIKNQLLVLTSILILLSLEVAPVVTLAAELPSSSLQTALSS
                     ETTITSEEKVTETTETTVATSTTSTSSSSSESSSSSDTTTESTSHSTTETTTTNTSSET
                     KKEPTEPTVSSEITQPVEQSQPPQVPVTKQEPEEPIQVPEATNNVVEENQAVSLNPSLK
                     VDEIASSNLKGYELPLLSSFGEKKRAVVVAEALRHVGKTKKEFNLTEQALTSSFLAQKI
                     YQQLFKIDIGSTPQEQMTFGKARSIEEAEPGDLIFWQTAEGKTLQNGVYLGQGKYLIAA
                     AEADSKEKSEVIGQLENIYTTKQQPDSKEEIRLVVTNPFKEFTLTEYGKEVLATYGASF
                     EMQKSEQTTAFIKKIGETARELGEKYDVFASVMIAQAILESGSGESQLAKEPYYNLFGV
                     KGSFQGNSVSFSTKEADQRGQLYTISAGFRDYGGYNDSLQDYVQLLRQGIDGNQDFYKP
                     AWRSEAKNYLQATRFLTGKYATDKQYDNKLNSLIAVYNLTQFDLPKTADGLIIQSKNEL
                     SEAEQQQMHFPVYDGINYNRSGSYPVGQCTWYVYNRFKQLGTSVDEFMGNGSDWGRKGR
                     ALGYQVSSLPKAGRAISFQPGVAGADNQYGHVAFVEAVTSDGIIISESNVINDQTISYR
                     VLPNAIAYSSGVTYIGA"
     gene            complement(14008..19635)
                     /locus_tag="EB41_RS03670"
                     /old_locus_tag="EB41_00710"
     CDS             complement(14008..19635)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016633936.1"
                     /locus_tag="EB41_RS03670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00710"
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="WP_162783904.1"
                     /transl_table=11
                     /translation="MGSNFKEEKMNKEYQGKKIYGKKHWLTFLLVSSSVLAFHSLVTMD
                     SQVVDAQEQTAKEDVADSATSVGAIVSIEKAEKNFVITYASGKKAQISILNDHLFRYHL
                     DPTGKFEEYPTPNDPKHVAKITAKTMADYGTQAFEQTNVTDSGNQFILENNGLKIMFEK
                     ESALMKVLDKKKNQVILEETAPLSFKNDKATQTLKQSSQENYFGGGTQNGRFTHKGTAI
                     QIVNTNNWVDGGVASPNPFYWSTAGYGVVRNTWKPGNYDFGSHDPQTTTTTHEGTDFDA
                     FYFFNDSSAGILKDYYELTGKPALMPEYGFYEAHLNAYNRDYWVKVAEGTAGAVKFEDG
                     NFYKEYQPGDLGNLNGTLESLNGEKENYQFSARAVIDRYKKNDMPLGWFLPNDGYGAGY
                     GQTDSLDGDVQNLKEFTEYAQANGVEVGLWTQSNLHPADPKNPKKGERDIAKEVSVAGV
                     KALKTDVAWVGYGYSFGLNGVEDAANVFVKETDGAVRPMIVSLDGWAGTQRHAGIWTGD
                     QTGGQWEYIRFHIPTYIGTSLSGQPNVGSDMDGIFGGKNKEVNIRDFQWKTFTPVQLNM
                     DGWGSNPKTPFAFDQEATDLNRAYLKLKSMMMPYNYSIAKESVDGLPMVRAMALEFPNE
                     GTAYTKDSQYQYMWGPNLLVAPIYNGNQDEAGNSIRDGIYLPDEKQVWVDLFTGEKYQG
                     GRVLNGVKTPLWKVPVFVKDGSIIPMTNPNNNPKEIQRDQRSFLIYPNGATSFNMYEDD
                     GISTSYEAGQSATTKINSQGPKSNEKGDLTVTIEPTKGSYKGFVDERSTTLDLLASEAP
                     ESVTAMVGGTEVTLKQAANKEEFLAGTNLYYFDKEFQVNQYLSEASGEKLNQSALSVKL
                     AKQSVTAKDVQITVNGFINKGTIDGGNTTVDDQLTIPANVAINEEKTTPSSLTLQWDQV
                     TEATSYEVERDGTVFGNIQTNTATFDGFSFLSEHTFRVRAVGKNGVSEWSEPIKGKTQD
                     DPYKETINQVKATSNLPEQPGAELKKLTDKDLSTGWHTNWSTGIANPSDGNFLTLKFDL
                     GAEYQMDKIEYLPRDNAGNGNILQLQYRTSKDGANWTEFSEPINWKQDALTKTIETKDQ
                     AYRFVEMKVLKSVGNFGSGREMLFYKQPGTEGILNGDITNDGTIDENDAMSYRNYTGLE
                     SLDSDFNGYVEKGDLNKNGVIDAYDISYVLRQLDGGIEIPDVEEIAGGLSLAVVNENGK
                     DTYLPGDTLTFTLKGQDLKNINALSTKMSFDSSKFELVGQPATTNNTQHMENYSKYRKH
                     SNDVENLYLVLSNQGNKQLLNGSMDLVTFKVKVKETTRVKRATTVEQSLQFDMSQGLLV
                     GQGFQQATLSDFSVTVKPTELVDKELLQALITLNQARVEKEYTPETWAIFKPILDEAVA
                     VLANEQATQTDVSAAVENLEKAVEQLEKMPDVANKADLEKAIQEGLTKKPSDGQEFTEE
                     TKKVLEESLAAAQKVFAQEKVTQEEIDQATKTLREAIAQLKEQPVAVDKETLKEKIAQA
                     RGIKPEEGYQFTKETEKQLQEAIQAAEAIVAKETATKEEVSAALNALETAMAQLKEVPL
                     VNKDQLQEVVKRAQQVTPSEGHQFTASSLQDLQKALLAAKNTLENPAANQKMIDEAVAE
                     LTSAIDGLQEEALVTDKKALEAMIAKAKAIKPSAGKEFTSESKARLTEAIDQAEGILAD
                     KNARQEQIDTAEKNVKTALDSLEEQVLQTDKTKLKELLQKAETLKSKAGKQFTKVSQEA
                     LAEAIKQAKALVEDPNATQEAVDKCLSILAQAIEAMAEEPISSNSTGNNRNHGTVSGTG
                     SVTSPGKGTAAGGTTTKTTTSGTLPKANEVVSPIWSISGFLLIVSIGLGKLFFKNKKDQ
                     N"
     gene            complement(20138..20533)
                     /locus_tag="EB41_RS03675"
                     /old_locus_tag="EB41_00711"
     CDS             complement(20138..20533)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002407764.1"
                     /locus_tag="EB41_RS03675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00711"
                     /product="hypothetical protein"
                     /protein_id="WP_002408845.1"
                     /transl_table=11
                     /translation="MDGMFANLTLRERRLLKQAQVGATISFILLFVPILTISLLHTSDS
                     LAKWLGIVGVIMVLPLLYFAWQILKIAYKDQKDNPTPPLWVPKVYGIGLSINPYHRFGK
                     LIFILLAVLIVGIIISLLFTPASQINH"
     misc_feature    complement(20680..20694)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.5"
                     /tool="antismash"
ORIGIN
        1 ttttcaaaag ccacatcata gttgtagtcc tttggttgaa cttcttggaa tccttgtggt
       61 ttataaaaac gtaaaaggtt ttcctgattt aatttgtcag ataaacttaa cgattttttc
      121 acccaatcgt tatctttcgt gacttctgct tttaaatctg ctggaacttg gtctaatttt
      181 ttcccttgat tattgtagat ttccccacct agataagaaa attgaggcgt tacaaaatcg
      241 ccatttctaa aaggaaccac ttgtttatat tgaggagata aaaggtccgt gccaaaatgg
      301 atataatttt tatcatcgac acctaaaaga tggtacagtg tcggtaaaac gtcaatttct
      361 ccaccatatt cgtgcatgat tttcccttgc gtatagcctg gcatgtaaaa catcaaaggt
      421 actctttgca attgcgcatt gtcatagttt gtccacgttt ttggatcgcg gttgaaggct
      481 ttacataagt ccttgttgtt tgcatctgaa ataccgaagt gatcaccata aataacaaaa
      541 atagaatgat tgtataaact tgttgtttgc aagtaatgga aaaattgttc tagcgattga
      601 tccaaatagt gcgctgttcg aacataatca tccacaatcg aattgcctgt gttcaattta
      661 ggaaacggga agttttggtc atccgtataa taaggggtat gattggtcac agttaaaaac
      721 ttcgcataga atggctgctg taaatgctca agctcactag ctgattcacg caacaattgt
      781 ttatctaaaa taccgtaacc tagcattttg tcatcttttg aaaaatatga ccgatcaaaa
      841 aagtattgat atcctaagtt tttatacaca tggtctcgat tccaaaaact ccccacattt
      901 ccatggaaaa cagcggttgt atagcctttt tgtcctaaaa ctgcgggagc cgcttcgaaa
      961 gtattgtctg atcctaattg tgtaaaaaga gagccttgcg ggagcccgaa tgttcctgtt
     1021 tctaacatgt tctccgcatc actcgttttt ccttgcccta cttcatgaaa gaaattatca
     1081 aaactgattg tcgctttgtt ttgatagagc tgatttaaaa acggtgtaac ctcttggcct
     1141 tggactttca tattaatcaa aaattgttga aaactttcta aatgaatcac aaatacattt
     1201 tttcctttgg caatcccggc atactgcgga ttaagcggta aattattttg cttggtaaat
     1261 ttcatgattt caggtaattc gtttgaacta gcttctgctc ttacctcatt tgacatggct
     1321 gttttgacac catcgatggc tgtgaatgca tccaagccaa gatattttac aatataatta
     1381 cggtcaaaaa ttctttgaag caattgagga cgatcggttt cgcttaaaaa taagttaacc
     1441 gaaaagagca agacacttaa acaactaatt gagatcgcca atcttctgtt gataggttta
     1501 gtcatgaaga cttgatgatt ccgtcgctgt ttaaaagagt aaaataccaa aacgagcagc
     1561 actaaagtat ctagccaata aaagacatcg tggaccctca ttaaggcaag taaatcacca
     1621 gaaatccctt ctgaaacttt tgaaaagcca aaaacagatt ggatggtaat aaagtcagtg
     1681 aattcacgat aaaaaataat attcaaatat aaaattaatg tatttaaaac atttaaaaga
     1741 gttaagctaa gcataaatgt tttatgcttt ttaaaataca aactaaagcc aaataataac
     1801 agcgtagtag caactggatt gaaccacaaa atttctcgtt ggagactgcc cttaacgccc
     1861 aatgagaaat ctaggtaata cgccagaatc gtttttgccc aaaagagtaa aacaaaaaat
     1921 aaaaagagtc ctaatcggtt atttattttt ttcatctaag tttgtcttcc tttcccttca
     1981 aaaaaatctt gatttgttaa aaataaaacc taactctgcg caatgacttt ttcgctagcg
     2041 gagaattgga taaataactt aaaaagataa tcgcaatggc gcaacatcca aataaaagcc
     2101 atacgtttgt aaaaggtgtt cgagtaaggg aactagtaat aggctttgta attaaaagac
     2161 ttggtagcgc cacccctaaa gaattgccaa tttgcttaca tgtcaccgca atggctgctg
     2221 ccgttcctga ctgagaaaat ggcattcctt caatcgctgt aatggtaatc ggtgaattta
     2281 acatcccaaa cccaatgcct aaaaagatat aaataacaaa taaaataatc ataggcgttg
     2341 ttttagttac aaataattgt aaaaagctaa cagccaacat tgaaatacca caaagcataa
     2401 taggacgttt cgtccctatt ctccctacca tttcgccggc tctcggggca acaagaaaac
     2461 taacaaaagc caaaggaatg gttgataagc cagcttccaa cgggctgaag cctctcattt
     2521 cttgcaaata tagcgtgttt aaaaataaat aaccgttata tatgataaag ccaaaaatag
     2581 ctaaaaaaga agccgatgta aagggaatag ataaaaagaa gcgcggattg attaacggat
     2641 tgtcaatgtt atattcataa ataaagaaaa taacaatagc taagcagccg attatcccag
     2701 tacttaaaat atctggcgcg aaaagccctt ttctaggtag tccgataatg gaatagatag
     2761 aactaaatag aaaaagaatc atcaatgctt gaccaacaaa atcatttttc accgtcttct
     2821 ctacttttga ctcaggtaca aacttttgtg taaggatgat tgccgcagca atgatcggta
     2881 cattgacaaa aaagacatac ctccagctaa aataagaaac aatcagtccg ccaataatcg
     2941 ggcccattcc taaggaaatc cctgtaacag agccccacaa gccaattgct ttcgctcgtt
     3001 ctaacttttc ggtaaatacc tgtgtaataa tagacattgc taccggattt aacatagaac
     3061 caccaatccc ttgcaacatg cgaaacgcaa tcaattgccc tggggtttgc gaaatcccac
     3121 ataggaaaga cgctaaacca aaacaggcta agcccaattg aaggactcgt ttacggccaa
     3181 ttcggtctgc tgtagaccca gataacaata ataaggatgc taccattaaa gtgtacccat
     3241 ctgttaccca ctgtaatgta gacagattcg tgtgaaaatc actttgaatg gatggtaacg
     3301 ccacattgac aaccgtaaca tccatggtca ctacaaacaa actcatgcaa caagtataca
     3361 aaataacttt ttttctatcg atcataaaaa cagtcctttc tagcaactac ataaaacagg
     3421 aaaaacaaca atgacactta aacttctaac gacacgatta tcgcaagtac tcacgtatca
     3481 acagttcttt atattgcttg ccatttagtt attttatact taaaaaagta aatctttaga
     3541 tagccaaact atacaccaga acccttttaa attgaaccgt aatagatacg atttatcgat
     3601 tcttaagtta ttaaataatt gaacattccg ttcagaaata tcgaacagtc ccataattga
     3661 gcatctcttt taaacaatga acaacaaaaa tagccttatc cgcagcagaa gtaaatctaa
     3721 gcgaataaag ctatttttag taactattcc aaagtaattt taatggctaa gtctctagca
     3781 acttttgtaa agttgccttg atttgaccag gttggacaaa aaccgaactg gaaacatttc
     3841 ggtataaata aaatttttgt tttcgttcaa tcggtaaaaa gaagagttta gaatcaattt
     3901 cctgcagttg ttctttccga agagagatca ccgcataaac tcctttactt ttttcaatga
     3961 gacgagtaag catcaacgta tcgtagcaac aaacaagcgg acttgttaat tgcaacattt
     4021 ctagcacact cttggtagct tctaaatgat ctaagtgatg aggcaaaaat agaaatggat
     4081 agttggtcaa acagatgaaa ccttcttcct caatttcttg tttaatttct cttgaaacac
     4141 aaagatacat ttttagttca attaattgtt ctttctttaa aactggacta ttcacatctg
     4201 cagaagtaat cacaaaatcc aactcatgat tctccaattt attcaataac tcaaacgatg
     4261 aaccatggta acattcccaa aaacgattca gttgatcctc attttctgtc actttataca
     4321 tcaaggacgt atttccaaaa cctaaacgca tcactggatt ctcaatcatt tcatgcaaat
     4381 taagtttcat tttcttggcc tcgtttaaaa tgatatatac agattggacg attttatcac
     4441 cataggaatt taacgtcaaa gaattcccgt tacggtcaaa aagtaaatgg cccaattcac
     4501 tttccaaatc ttttaatgac gcacttaagg ttgatttact aacatgaagt tcagaggctg
     4561 ctttggaaat actattatat tttgcaatgg tataaaaata ttctaatttt tcaatagtca
     4621 tcttttgtca tcccttttat tcaaattcaa ttgcccacgc aacctgttca aaacacgcct
     4681 cactctttat caatagcgta gttatttttg ctctaataag ctatgtccat cttgttattt
     4741 ttctataact aatagcagat gaatatgaaa gtgcctttgg taaaactttt tctcggaaat
     4801 agcatgaaca ttcacaacaa attcagctta ttaaaaaagg cgtctagctt tttctatttt
     4861 acgcaaattt acttaagaaa ttccatttca attcttttct aaaaaaggta agatggacac
     4921 aacaaatgtt tcagtttcca tgcccattta ctttaaggtt cagcgttatc tactaagtat
     4981 gaagaatgtc aaagaaaggt taggtactcc caatgaaaat caactattta ggtacgggtg
     5041 cagcagaacg gattccagga attttttgta attgtaaatt atgtaagtac gctcgagaga
     5101 aaaaaggacg agaaattcgt acacaaactc aattaattat tgatgatgtc ctgctgattg
     5161 attttccagg ggattcttat ttacacctgt tgcagtacga cttgtgtttt gcagactttg
     5221 actctttact aatctctcat tggcattccg atcattttta cggcgaggat ttggcttatc
     5281 gaatgtctgg ttatgcatta gatattccca atcgtttaac tgtttacgga aatgaagcag
     5341 ttaagacgtt ttatcagcgc gcctttgatt tagaaggtcg gcaagatgat acccgattac
     5401 attatcaggt tattcagccc tacaaatgtt ttactattgc gaactatacg atttatcccc
     5461 ttcctgcaca acatggaaat ttcagtgaag attgttttat tttcgttata gacgatggta
     5521 aagatgcttt tttatccacc catgatacag gttactttac gtcagaaatg tttgaatatc
     5581 ttgaaaagag ccacttactt cttagtattg tttctttaga ttgtactagt caaacaaacg
     5641 aaactggcaa tagtcatatg aattgggaag aaaatttaaa attaattaca gaattaaaag
     5701 aaagaaaact cgtcacagat aaaacgattt acgttgccaa ccatttttct cacaatggcg
     5761 gcttgtcata tgcggagatg gcggctttat ctcaaaagca tgaaatcatt acgagttatg
     5821 atggtttaga aatactaact taatcggatt atttgccttc ttttcagcac tattatatgc
     5881 ttttaaccga taattacaag gtacttttat cgtaacttac actatcttaa aaaacaaaaa
     5941 tactcgagat ttcccgtgat tctggaaatt ccgagtattt ttatggttct ttacgctgct
     6001 ggcacagcgg ataaacgttt attttcttct tcattcactc gattgacaat aaagttataa
     6061 ttcacttcat ttagtctttg accatggttt cctgtttgct taatgccgcc attggaatga
     6121 acaccaacta cttcaaactg agcattatag attggggaac cagattgacc acctgttgta
     6181 tcgatatcat aaaatagtaa tggattttct aagtctgtaa agttagatgt aaacaaatca
     6241 ttttcatgag accattgtgt gtggtttttc tcacctggat agcctgatat tgtgacatgg
     6301 gtatctgaag attcaaactt tttcaaaaca aatggcgtta aaatttctcc caactctggg
     6361 ccatctggac gatcgttttg tttgctgaca gtcactaccg caatatccgc attcggggaa
     6421 aaagctacat caatcacttt gaatttacca aatggtgtcg cactgccatc tcgacctgga
     6481 taaaaccaag catcatcttt ggcattcgga tttaatactt tggcattctt aaaactttca
     6541 gccacatgat tattggtgac aattgtatta gttccaacaa caaagcctgt tcctaaagaa
     6601 atatagcctg gtttactggc aggggaaatg attcttccga ttgacgcaaa aggcgcttcg
     6661 gttgtatctg ccacttcttg tcttctgtct tcagggtcca gtaacgatct tttttgtcgt
     6721 gaatgacttt cggcaggaac gatatactct tctgcatttg cagacaagct aaaaccggcg
     6781 atcaaagtta ctaaaatcag aaacaaaaaa ccagcactaa tttttcgtat ggagaacttt
     6841 ttcataagat tatgccactc cttatccatt tttatttaat tggggaattt ttttcattca
     6901 ttgaccagaa cagattcact tggttggttt acttgaatat cctctttagc tccgattcca
     6961 gcagagttaa aggctgctga caccactgaa gctgcttcat cgccatattg aacttttgca
     7021 gcagcaagca tcgcatcacg agcatcactg aattgtgctt taggtgttaa gtaatttact
     7081 aacgagctgt agaaaatagt ctgtgctttt tcaatgccta agttctggat aatggtgtaa
     7141 ccaatccgat taataattcc actattataa tgaacaccgc cttgatcata ataaggcgtt
     7201 cctttatacc gtgctcgatc gtcgtattga gccatggttt ctggttgtcc gtgtttactt
     7261 ggcgtttgta aatttcgaat acctgttttt cggtcaacac tctgagtatc cgcaccaatt
     7321 tctggattag atgcacccga aataatataa cccatcaaat cagaataaga ttcattcaag
     7381 gcacctgatt gtcctaaata ttctaaaccg gcagtatgtt ccgtcacacc atgtgtcatt
     7441 tcatgaccaa ctacatctaa agaggaagca tacgtttttc ctgttggtgt acttgtttca
     7501 ccataacgca ttgcttttcc atcccaaaaa gcattgtcat aagcatctgg atgttgttca
     7561 tcaacaactg acaagatggg catccctcga tcatcaatac tgtgtcgttg gaaatgatct
     7621 tcataatatg ttttcacaaa ttttccatgc gtataggcgt caacagcatt ctgatttaat
     7681 gtcgctagtg atggcgcttg aataatagaa taattatttt tgccatcaac tactgcatgg
     7741 taaacccctg tgttatccgt tccgtgtaaa gcaattcccg tattgctttt ttcaactggt
     7801 acattaaacg ttacttgaaa agagtttttt aacgttactt cactaccgac atgttccgtt
     7861 aaatcttgtt tttccataat tgttccatct gtagcgttca ctttataaac caatgatacg
     7921 gggtcaccag ttggtgaaga agttactctg actttataaa ataattgccc ttcattattt
     7981 acacgtttgt caatagctaa aaagacaaga tctttatttt ccggattatc agaagcaata
     8041 atttttttaa ctccttcttc accgattgca tcaaccgatt gaattttcac aacttgatca
     8101 actggatttc ctgtaacact tgttactgca ccgtttttat ctaaatgaat aatcacatta
     8161 tctgaatcaa cagtaacgcc ttccgtttgc ttttctaact taagatgctt catcccccac
     8221 gcgtcttctt ttcgatctac aaccgtatat tgttcagcag ctgcctcaga aattgcctcc
     8281 ttttccaact tcgataaaac tgttgaaact tcactttctg aataaacttg ttcttctgcg
     8341 gctacaaaaa gtgaagaaaa tagacatgaa cttccaacaa agatgcctgt acctaaaatg
     8401 tataaaattt tatttccctt catcaaacaa ttaactcctt ccccagtttc cttttatttc
     8461 ttttcccaac aaaagtattg ctttatcctc cctaattttt cccgttaaac gaccgcccct
     8521 ttccctgcgt aaatatttgt tgctattttc attatagaca actacctaac cggcactatc
     8581 taaattcctt aatcagccga catttttccc tgtattgccc ctcataactc aataccatag
     8641 caaaaaagtt gttaacaaat tcattcgtta acaacttttt tactgttatg atttttttca
     8701 ataattaaat gttgagtaac cgatccttca ttgaaggacg tttgcaaatc aaattgatct
     8761 gaaaaatcaa caatttcttt tacgtataac aatccccaac cgtgctcttc agggttactt
     8821 ttagaactaa atttggtttt cttcataacc ctaaaatcaa attcggcttg gacactattt
     8881 gttatcacaa actcttgtgt ttcattttta ttgaaaattg agattgcgaa cattttcaat
     8941 tctgattttg cactgttttc aatcgcgtta tctaatagaa tagccaacaa acgaatcaca
     9001 accactaagt cgattgatgt atcaagaata aatacttctg gcacatcaac aatcactttt
     9061 agttttgctt gctttgcggt attaattttc atacttatga gtgccttaag ttccatattt
     9121 ttcaaacgat ttaacttcat aagttcaaat tcttcattat caataatttt tttggttggt
     9181 gcaatcgttt cttcataaat tcttttgatt tccagaatat cttcgtatga aatagcaatt
     9241 tgtaaactat acaataaatt tttataatca tgacgaaaca tcgctagctc ttcgttaatg
     9301 gattctattt tttcagtata aatcgttaaa ttattcaata attgagtgtt gatacgttgt
     9361 tcttccaaat aagcttcaat gactaagcca atcagaatta aaaataaacc tacacttatt
     9421 aataactcca atttagaact atttaccgtg acaaatcctc gcataaagtc aggtgaaatc
     9481 tctggcgaaa tcaaaaacac aaaaagtaac aacagaatca acaataaaag taaacaacca
     9541 aaaaaaattc ggctattttc taacacacga tttaatctta aaaaaacact attgggaatt
     9601 tttaaagcaa tccagatatt tataagcaac agaagaacat ttgaggcaat ccataataat
     9661 ttattttgat aaatctgttg aaaaaaaaca cttaaaatcg tttgctccgt gtaattgata
     9721 aacgaaacca taagcaatgt aaaaacggat aaaaatatcg ctttaaaaat tgagaacctc
     9781 tttttgtgaa tgagtaaaaa tcctgtaaaa acaacgactg ttagcgcata aatcaaccaa
     9841 gagtagccca acattaatgc cgcaaacgaa caaagattaa tgacaataag caatgaaagt
     9901 aacggtattt tacattcaat cttgatcaat gttactcgta aaaagacaaa aacgataaag
     9961 ctagatacaa gcaaaacgtt agtagctaat aacgacaaaa tcatttttca atattctttt
    10021 taggtttttc agtttgtccc atccattgtc caaatatatt gggcgaattt tgatttaatc
    10081 taggcttagt tcccacacca tcactgactt ttgcaactct tttttcaata acatttttaa
    10141 ttattttttt accaaatttc ataaaaacac ttccttcaat taaatttttt gttacaggga
    10201 gtatcatcag accttggatg acgagaccgt agagtattac tgaagcaatc ttttctttga
    10261 caaacagact acataaaata agtaaacaca cccttataag gctttgcttt ttgagcacgt
    10321 ttaaatcaga tggctgaaca ggttcaattg ctgttccttg tggcgcatac caataaaata
    10381 atacgactaa gaggcacatc gatagaattt tataaataaa cggtaagctc acagaagaat
    10441 ttttcaatac aaatggtatg gcaacataga taacaatgct ttctagacga cagagccatt
    10501 tggtttttgc atgccagcca cctgcgacag gccgtaaaaa aatcagtatg acgtatacaa
    10561 taaaggtttc gcttaacgtc ccaaataaaa ctgataaaat cagaatcatc agaaaattaa
    10621 ataagccaga aaaataaacg gttagataat actttgtcca ttgtgttttt cctgattgat
    10681 cttcctgatc catatccata atatttttta gaatccaatc gattagcata tcgccctcct
    10741 cttcaagtat tgcactaaat tataacgaat atagcgacta atagatagat aattccttaa
    10801 ttagtcatta tccctcccta agtaagaaat agcgccttga cctgagtata atatcttctt
    10861 gagactggta cttccgttcc gtctctcata gttaaaagat gcgttttata atttaatttt
    10921 gacgcatatt ttttattgat gatgattgat tgatggactc taatcaaatc tggatgcagt
    10981 tgttcaattt ttgataacgt tccataaaat tctcttttaa aatttttacc aaccattgat
    11041 acacgatgat cgtattccgt ttgaaagaaa taaatatcat taatatccat ttttatagaa
    11101 gatgctttta agttaatgat aatatattca ctttttgtct ttatattttc tttttgttga
    11161 atatatgcat cgacacatgt ttcgacctct ttttggaaat ctagaaaatc cacgttcttt
    11221 tgaataaatt gaagagctga aaccatatat ttgtaggaag ttaaaactaa ttctgtgtga
    11281 gtagaaataa atacaatcag actttcactg tctgtttttc tgatttcttt ggcaacctca
    11341 aatcctgcct ggatatgatt gttcatttga atatctagga aaaagatatt tagttgggcg
    11401 tcctggtgtg ccacttgtaa taattcatct gaacgtgaaa ataaatggat tgtttcatta
    11461 taaatatttc ttgaatgtag gatatttgtt aacaatgctt ctaacgcttt tgcttgaata
    11521 atttggtctt ctaatatata aatagccatt tgttcactca tccctttctc aagaagatat
    11581 aaaattacac aacaaaagac aaatgattat aatgttcaat caatttatac accaataaaa
    11641 gagataaaaa attgattgtc tgttagtata ttcacataaa tttagtatag cgatttcagt
    11701 agtttcctgc aaacaaaaac ataaaataac aaagcatcaa gaaagagtac tttggactat
    11761 tcatcttttt ctaacgaatc atgaggacga ttgtctcttc gttgatgaaa aacaaagaat
    11821 caaccgccaa actgttcttg tcattttata catgacaaaa tcaattcatt ggtcgattct
    11881 ggttatttta atttgttagt tcacacatgg atcattgtgc taacttttta cttaaacatc
    11941 cacacttctt cctgttgaat gagtcgctta agcgccaatg taggtcacgc cactactata
    12001 agcaattgca ttaggtaaga cacgatacga aatcgtttga tcattgatga cattgctttc
    12061 agaaataatg attccatcag aagtgaccgc ttcaacaaaa gcaacatgtc catattgatt
    12121 atctgcgcca gcaactcctg gttggaaact aatcgcacga ccagctttag gcaatgaact
    12181 aacttgatag cctaatgcac gtccttttct tccccagtca ctgccatttc ccataaattc
    12241 atccacagaa gtgcccaact gtttgaaacg attatagaca taccacgtac attggcccac
    12301 gggatagcta ccactccgat tataattgat cccatcatag actggaaaat gcatttgttg
    12361 ctgttccgct tccgacagct catttttaga ttggataatc aaaccgtctg ctgtttttgg
    12421 taaatcaaat tgcgttaagt tataaaccgc aattaacgaa tttaatttat tatcgtattg
    12481 cttgtctgtt gcatatttac ctgttaaaaa acgcgttgct tgaaggtagt ttttggcttc
    12541 cgaacgccac gctggtttat aaaaatcttg atttccgtca atcccttgtc ggagtaattg
    12601 aacataatct tgcagtgagt cattatagcc accgtaatcg cgaaacccag cggaaattgt
    12661 ataaagttgg cccctctgat cagcctcttt tgttgaaaag ctaacactat ttccttggaa
    12721 cgaacctttc acgccaaaga gattataata aggttctttg gctagttgac tttcgccaga
    12781 gccactttct aaaatagcct gagctatcat cactgatgca aaaacatcgt atttttcacc
    12841 aagttctctg gctgtctcac caattttttt aataaacgct gtggtttgtt ctgacttctg
    12901 catttcaaat gacgcaccat atgttgctaa aacttctttg ccatactccg ttaatgtgaa
    12961 ctccttaaaa ggattagtca ctaccaagcg tatttcctct tttgagtctg gttgttgttt
    13021 ggtagtatag atattctcta actgaccaat tacttctgat ttttctttag aatccgcttc
    13081 cgctgcggca attaaatatt ttccttggcc aagataaaca ccattttgaa gcgtttttcc
    13141 ttcagctgtt tgccaaaaaa tcagatcacc aggttctgcc tcctctatag aacgagcttt
    13201 accaaatgtc atttgttctt gcggcgtact gccaatgtct attttaaata attgttggta
    13261 aattttttgg gcaaggaaac tactggtcaa tgcttgctcc gtcaaattaa attctttttt
    13321 tgttttccca acgtgtctta atgcttcagc caccacaact gcccgtttct tttcgccaaa
    13381 agacgacaac agtggaagtt cgtagccttt taaattagaa gaagctattt catctacttt
    13441 gagggacgga tttaacgata cagcctgatt ttcttcaaca acgttattgg tggcttcagg
    13501 aacttgaata ggttcttcag gttcttgctt ggtcacagga acttgtggtg gttgcgattg
    13561 ttcaacaggc tgagtgattt ctgatgatac cgtcggctct gtaggttctt tttttgtttc
    13621 agaactagta tttgtggttg tcgtttctgt cgttgaatga ctcgttgatt cggtagtcgt
    13681 atcgctagaa ctacttgatt cagatgacga actactagtg gacgttgtcg atgtagcaac
    13741 agttgtttcg gttgtttcgg ttactttttc ttccgaagta attgtcgttt ccgaggacag
    13801 agctgtttgt agcgagctac ttggtaattc tgcagccaac gtaacaactg gagcgacttc
    13861 caaactcaga agaatgagaa tacttgttaa aacaagtagt tgattcttga ttttctttct
    13921 tttcattcgt aaaaatcctc tcctattact tacttgcgca tttgcacact gtttttgtac
    13981 aaatgcgcct tgtaagttaa tgatacgcta attttggtct tttttatttt tgaagaataa
    14041 ttttcctaaa ccaatactta ctatcaatag aaaaccactg attgaccaga ttggcgaaac
    14101 aacttcattt gcttttggca aagtaccaga agtggtggtt tttgttgtcg ttccacctgc
    14161 tgctgtgccc tttcctggac tggttacgct accagtcccg ctaaccgtgc catgatttct
    14221 attgttgcct gtagagttgc tactgattgg ctcttctgcc attgcttcaa tggcttgtgc
    14281 taaaatactt aaacatttgt ccacagcttc ttgcgtcgca tttgggtcct caacaagtgc
    14341 ttttgcttgt ttaattgctt cagctaaagc ttcttgcgat acttttgtaa attgttttcc
    14401 tgctttagat ttcaaggttt ctgctttttg aagcagttct ttcaactttg ttttatccgt
    14461 ttgaaggact tgttcctcta aactatccaa agcagttttt acattttttt cagcagtatc
    14521 aatttgttct tgccgagcat ttttatcagc taaaatccct tccgcttggt caattgcttc
    14581 agttaagcgc gctttagact cgctggtaaa ttcttttccg gcagatggtt tgattgcttt
    14641 tgctttggct atcattgcct ctaaggcttt tttatctgta actaacgctt cttcttgtaa
    14701 cccatcgatg gcactagtta attcagcaac cgcttcatca atcatttttt gattagctgc
    14761 tgggttttcc aatgtgtttt tagctgctaa aagcgctttt tgtaaatctt gtaacgagga
    14821 ggcagtaaat tggtgccctt cacttggagt gacttgctgc gctcgtttga caacttcttg
    14881 taattggtct ttatttacaa gtggtacttc ttttaattga gccattgcag tttccaatgc
    14941 gtttagagcc gctgagactt cttcttttgt cgccgtttct ttcgctacga ttgcttcagc
    15001 tgcttgaatt gcttcttgca attgtttttc tgtttctttt gtaaattggt atccttcttc
    15061 cggctttatt cctcgggctt gagcgatttt ctcttttaag gtttccttat caacggcgac
    15121 gggttgttct tttaattgtg caattgcttc acgcaatgtt ttagtcgctt ggtctatttc
    15181 ttcttgggta actttttctt gagcaaatac tttttgagct gctgctaatg actcttcgag
    15241 aactttttta gtttcttcgg tgaattcttg cccatcactt ggtttctttg ttagcccctc
    15301 ttgaattgct ttttctaaat cagctttatt cgctacatca ggcatttttt ccaactgttc
    15361 tacagccttt tctagatttt ccacagcagc agaaacgtct gtctgtgtgg cttgctcatt
    15421 ggctagaaca gctactgcct catctaagat tggtttaaag attgcccaag tttcaggtgt
    15481 atattctttt tcgacacgtg cttgatttag cgtaattagc gcttgtaata actctttatc
    15541 tactagctct gttggcttca ctgttacaga aaaatctgaa agtgtggctt gttggaatcc
    15601 ttggcccact aataagcctt gactcatatc aaattgtaat gactgctcaa cagttgtcgc
    15661 acgttttacg cgagttgttt cttttacttt aactttaaag gtaactaagt ccattgaacc
    15721 gtttaacaat tgtttatttc cttgattact aagaactaaa tatagattct ccacatcatt
    15781 tgaatgtttc cgatatttag aataattttc catgtgttgt gtattattcg tggttgcagg
    15841 ctgaccgaca agttcaaatt tgctagaatc aaaggacatt tttgtgctta acgcattaat
    15901 gttttttaag tcttgacctt taagtgtaaa ggttaatgta tcgccaggaa gataggtatc
    15961 cttgccattt tcattaacca cagcaaggga taaaccgccc gcaatttctt cgacatcagg
    16021 tatttcaatc ccaccatcta attgtcgtaa aacataactg atatcataag catcaattac
    16081 cccattttta tttaaatcgc ctttttcaac atagccatta aaatcactgt ccaacgattc
    16141 taagcctgta tagtttcgat aactcattgc atcattttca tcaatcgttc catcgttagt
    16201 aatgtctcca tttaagattc cttctgttcc tggttgtttg taaaagagca tctcacgacc
    16261 agagccaaaa ttacccaccg attttaatac cttcatttca acaaaacgat acgcttggtc
    16321 cttcgtttca atggtttttg tcaaagcatc ttgcttccag ttaataggtt ctgaaaactc
    16381 tgtccaatta gctccatctt tcgacgtccg atactggagc tgcaaaatat ttccgttgcc
    16441 ggcattgtct cttggcaagt attcaatttt atccatttga tactccgcac caagatcaaa
    16501 ttttaaagtc aagaaattcc catcacttgg attagcgatg ccggttgacc agttcgtatg
    16561 ccaacctgta cttaaatctt tatctgttaa tttcttcaat tctgcgcctg gttgttctgg
    16621 taaattactt gttgctttga cttgattaat tgtttcttta tagggatcat cttgtgtttt
    16681 tcctttaatc ggttcactcc attcagaaac cccatttttt ccaacagctc gaactcgaaa
    16741 agtatgttcg cttaggaagg aaaatccatc aaatgttgct gtattcgttt gaatatttcc
    16801 gaaaacagtc ccgtcacgct ctacttcata acttgttgcc tcagttactt gatcccattg
    16861 aagagtcaaa gaagatggcg ttgttttttc ttcattgatt gcgacatttg ccggaatagt
    16921 taactggtca tcgaccgttg tatttcctcc gtcaatcgtt cctttattaa tgaaaccatt
    16981 gacagttatt tgaacatctt tggcggtcac agattgtttc gctagtttta ctgataacgc
    17041 tgattggttc agtttttctc ctgaagcttc agaaagatac tgattcactt ggaattcttt
    17101 atcaaaataa tatagatttg tgccagctaa aaattcttct ttattagctg cttgtttcaa
    17161 ggttacttct gttcccccca ccattgctgt tacgctttcg ggcgcttctg aagctagcaa
    17221 atcaagcgtg gtgcttcgtt catcaacaaa gcctttgtaa cttccttttg tcggttcgat
    17281 agtaacggtc agatcccctt tttcgtttga tttagggcct tgactattta ttttagtcgt
    17341 agctgattgc ccagcttcat aactagttga aattccgtca tcttcataca tattaaaaga
    17401 agtggcgcca tttggataaa tcaagaaaga tcgttgatcc cgttggattt cctttggatt
    17461 gttgtttgga ttcgtcattg ggataatact gccatctttg acgaaaacgg gcaccttcca
    17521 gagcggtgtt tttactccat ttaagacacg gccaccttga tatttttcgc ctgtaaataa
    17581 gtcaacccag acttgttttt catctggtaa atagattcca tcacggattg aatttcctgc
    17641 ctcatcttga ttgccattat aaattggggc aacgagtaaa ttgggtcccc acatatattg
    17701 gtattgagaa tcttttgtat atgctgttcc ttcattagga aattctaaag ccatggcccg
    17761 taccattggt agtccatcaa ctgattcctt ggcaatactg tagttataag gcatcatcat
    17821 tgattttaat tttagatacg ctcggttcaa atctgtggct tcttgatcaa aagcaaatgg
    17881 cgtttttgga ttggagcccc agccgtccat atttagctgc actggtgtaa aagttttcca
    17941 ttggaaatca cgtatgttga cctctttatt ttttccacca aaaattccat ccatatctga
    18001 accgacattt ggttgtccag acaacgaagt cccgatatat gttgggatat ggaagcgaat
    18061 atattcccat tgaccacccg tttgatcgcc tgtccaaata ccagcgtgcc gttgggttcc
    18121 ggcccaacca tctaatgaaa caatcatcgg acgaactgcg ccgtctgttt cttttacaaa
    18181 aacattcgcg gcatcttcta caccatttaa gccaaaggaa tacccatacc cgacccacgc
    18241 cacgtcagtt ttgagagctt taacaccagc gacactaact tctttcgcaa tatcccgttc
    18301 tcctttttta ggatttttag gatccgctgg atggagatta gattgagtcc acagccccac
    18361 ttcaacacca ttggcttgag catactctgt aaattctttt aagttttgta catcgccgtc
    18421 caatgaatct gtttggccat agccagcacc gtagccgtca tttggcaaga accaccctaa
    18481 cggcatatcg tttttcttat atcgatcaat aactgcgcgt gcagaaaatt gataattctc
    18541 tttttctcca tttaaagatt ctagcgtgcc atttaagttt cctagatcgc ctggttggta
    18601 ttctttgtaa aaattaccat cttcaaactt aactgctccc gcggttcctt ctgctacttt
    18661 cacccaatag tcccgattat acgcgtttaa atgtgcttca tagaacccgt attctggcat
    18721 caaagctggt ttcccggtta attcatagta atcttttaaa atacctgctg aggaatcatt
    18781 aaagaaataa aaagcatcaa aatctgttcc ttcgtgcgtt gttgtggttg tttgtggatc
    18841 atgacttcca aaatcatagt tgccaggttt ccatgtattt cgaacaacgc cataccctgc
    18901 agttgaccaa taaaatgggt taggcgatgc tactccgcca tctacccaat tgttcgtatt
    18961 gacaatctgg atagctgttc ctttatgcgt aaatcgacca ttttgagttc ctccgccaaa
    19021 ataattttct tgactacttt gttttaacgt ttgtgtagct ttatcatttt taaaggatag
    19081 cggagcggtt tcttctaaaa taacttgatt ctttttcttg tctagaacct tcattaaagc
    19141 gctttctttt tcgaacataa tttttaaacc attattttct agaataaatt ggtttcctga
    19201 atctgtgacg ttcgtttgct caaaggcttg tgtaccatag tcggccattg ttttagccgt
    19261 aattttcgca acatgctttg gatcatttgg cgttggatat tcttcaaatt taccagttgg
    19321 atctagatga tagcgaaaaa gatggtcgtt taaaatacta atttgtgctt tttttccaga
    19381 agcatacgta atgacaaagt ttttctccgc tttttcaatc gacacaattg ctccgactga
    19441 cgttgctgaa tcagctacgt cttcttttgc tgtttgctct tgcgcatcaa ccacttgaga
    19501 atccatcgta acaagcgaat ggaacgccaa tacagacgaa ctcactaata aaaatgtcaa
    19561 ccagtgcttt ttaccgtaaa tttttttacc ctgatactct ttgttcattt tttcctcctt
    19621 aaaattgctt cccatagaat agttccgaca caattactca caaaatccaa aacccaacaa
    19681 agttttatcc agatgaaaag tcataacgat tttcttagtt tactgagact gttagaaagt
    19741 cagtttcagt aaccccttca taaacacatc ctttcaataa attattaaat gaaaacaatc
    19801 tattttcatc ttatataaaa attttagtac agaatcacaa tttcccgatg aatgcgtttt
    19861 catttgttga ctaccaattt ttcacttttt taataacata attatcgtat gatggttttt
    19921 ttgtgtttgt caacggttaa ttatagcagc caccattaac aagtattaac ccttgataaa
    19981 cctgttaatt cacttataat gatgatttta ttgcgaaaat atttacatca gaaaaagaaa
    20041 gactttttca aaaatctaat acctgttact caactttagt ctatttaaaa ataatcaaca
    20101 ccctcctgct cagcaagagg gtgtttaata attgttttta gtgattgatt tgacttgctg
    20161 gtgtgaaaag caaactaatg atgatgccaa ctatcagtac cgctagcaat ataaaaatta
    20221 actttccaaa ccggtgatag ggattgatcg aaagcccaat tccataaact tttggaaccc
    20281 acaaaggagg cgttggatta tctttttgat ctttataggc tatctttaaa atctgccacg
    20341 caaaatacaa caatggtaaa accataatta ccccaactat acctaaccat tttgctaatg
    20401 agtcactagt atgcaaaaga ctgattgtca gaattggtac aaacaaaaga ataaagctaa
    20461 ttgtggctcc cacttgtgct tgtttaagca gtcgtctctc acggagagta agattcgcaa
    20521 acattccatc catcctttca tggttttcag attaaatcaa cgaatcacta aaaaactaaa
    20581 ttaactgcga aaatcaatga ccattcgccc gcgaattttt ccttgttcca tttcttcaaa
    20641 aatagcatta atttcttctg gttggcgtgt ttgacaaaca ggaacaactt ttccttctgc
    20701 accgaattgg aaagcttcgc ttaaatctt
//
