LOCUS       NZ_KZ845881            21134 bp    DNA     linear   CON 11-APR-2024
DEFINITION  Enterococcus faecalis strain 262EA1 aekev-supercont1.1, whole genome
            shotgun sequence.
ACCESSION   NZ_KZ845881
VERSION     NZ_KZ845881.1
KEYWORDS    WGS; RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 2403193)
  AUTHORS   Earl,A.M., Van Tyne,D., Lebreton,F., Saavedra,J.T., Gilmore,M.S.,
            Manson Mcguire,A., Clock,S., Crupain,M., Rangan,U., Young,S.,
            Abouelleil,A., Cao,P., Chapman,S.B., Griggs,A., Priest,M., Shea,T.,
            Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genomics Platform, The Broad Institute Genome
            Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Enterococcus faecalis 262EA1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2403193)
  AUTHORS   Earl,A.M., Van Tyne,D., Lebreton,F., Saavedra,J.T., Gilmore,M.S.,
            Manson Mcguire,A., Clock,S., Crupain,M., Rangan,U., Young,S.,
            Abouelleil,A., Cao,P., Chapman,S.B., Griggs,A., Priest,M., Shea,T.,
            Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genomics Platform, The Broad Institute Genome
            Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JUN-2015) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R48559
            Genome Coverage                   :: 131.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003319555.1-RS_2024_04_11
            Annotation Date                   :: 04/11/2024 13:29:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,976
            CDSs (total)                      :: 2,907
            Genes (coding)                    :: 2,847
            CDSs (with protein)               :: 2,847
            Genes (RNA)                       :: 69
            rRNAs                             :: 3, 5, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 4, 3 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 3 (16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 40 of 60
            Pseudo Genes (incomplete)         :: 25 of 60
            Pseudo Genes (internal stop)      :: 25 of 60
            Pseudo Genes (multiple problems)  :: 25 of 60
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:38:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 274794
            Orig. end                         :: 295928
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KZ845881.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Please be aware that the annotation is done automatically with
            little or no manual curation.
FEATURES             Location/Qualifiers
     region          1..21134
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21134
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21134
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11134](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11134
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(293..306)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 25.18"
                     /tool="antismash"
     gene            344..877
                     /locus_tag="EB41_RS01475"
                     /old_locus_tag="EB41_00280"
     CDS             344..877
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002360460.1"
                     /locus_tag="EB41_RS01475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00280"
                     /product="hypothetical protein"
                     /protein_id="WP_002357809.1"
                     /transl_table=11
                     /translation="MGKVLEGLPLETVYFYALVGSAVLAFLLIIFGDVFNFDGPVDPML
                     IIPWIAFTSLFGYLGEELTAVNSWLILIVSGILSTIIVFFLNFYVLVPLKNSEATISIS
                     EKDMEGRVATVITPIPVRGMGEIQLKSVTGSLSRPAAFYVPQEVAAPRGSEVLIIELKE
                     RVCYVIPYEGSLKI"
     gene            894..2363
                     /locus_tag="EB41_RS01480"
                     /old_locus_tag="EB41_00281"
     CDS             894..2363
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002357808.1"
                     /locus_tag="EB41_RS01480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00281"
                     /product="flotillin family protein"
                     /protein_id="WP_002357808.1"
                     /transl_table=11
                     /translation="MGILLPIIIAVLVLLMLLIVFVSKYQTAKPDEALIISGSYLGSKN
                     VHVDEGGNKIKIVRGGGAFVLPVFQRSNRISLLSSKLDVSTPEVYTEQGVPVMCDGTSI
                     IKIGSSVEEIATAAEQFLGKTTEELENEAREVLEGHLRSILGSMTVEEIYQNRDKFSQS
                     VQEVASVDLAKMGLVIVSFTIKEVRDKNGYLDSLGKPRIAQVKRDADIAEAEALKETRI
                     KKAEAEKESQQAELQRQTEIAEASKEKELKLALYKQEQDIAKAKADQAYNLESARAQQH
                     VVEQEMEVKVVERQKQIELEEKEITRREKQYDSEVKKKADADRYAREQEALAQKAREVA
                     EAEAERFKVEALAEAEANKTRLTGQAQAEAILARGAAEAEAKQKIADAFKEYGEAAVLS
                     MVMEMLPQLMKEAAQPLGNIDKISVVDTGAGGENSGANRITNYATNLLAGTQETLKETT
                     GLDVKELIENFSKKGTSNSVNYHATEGSEKE"
     gene            2510..2743
                     /locus_tag="EB41_RS01485"
                     /old_locus_tag="EB41_00282"
     CDS             2510..2743
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002357806.1"
                     /locus_tag="EB41_RS01485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00282"
                     /product="DUF2969 domain-containing protein"
                     /protein_id="WP_002357806.1"
                     /transl_table=11
                     /translation="MSKKNKDIEVRVEEEKAQYNGANVLMNKLFIGKKEIGRVIPQNDK
                     KFIIEIDGKQEGTAKNLDEAFETIIRQWNLSE"
     misc_feature    complement(2758..2771)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.56"
                     /tool="antismash"
     misc_feature    complement(2759..2772)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.0"
                     /tool="antismash"
     tRNA            2840..2920
                     /anticodon=(pos:277668..277670,aa:Tyr,seq:gta)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EB41_RS01490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EB41_00283"
                     /product="tRNA-Tyr"
     gene            2840..2920
                     /locus_tag="EB41_RS01490"
                     /old_locus_tag="EB41_00283"
     tRNA            2930..3001
                     /anticodon=(pos:277756..277758,aa:Gln,seq:ttg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EB41_RS01495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EB41_00284"
                     /product="tRNA-Gln"
     gene            2930..3001
                     /locus_tag="EB41_RS01495"
                     /old_locus_tag="EB41_00284"
     gene            3156..3335
                     /locus_tag="EB41_RS01500"
                     /old_locus_tag="EB41_00285"
     CDS             3156..3335
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002357804.1"
                     /locus_tag="EB41_RS01500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00285"
                     /product="hypothetical protein"
                     /protein_id="WP_002357804.1"
                     /transl_table=11
                     /translation="MNFKEKITEMVENVYDLARDGKYDVKVDLIPRKKGNIKSGVKVTS
                     SRNTAHNIKWRSKN"
     misc_feature    3189..3200
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.7"
                     /tool="antismash"
     gene            complement(3391..4002)
                     /locus_tag="EB41_RS01505"
                     /old_locus_tag="EB41_00286"
     CDS             complement(3391..4002)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002419800.1"
                     /locus_tag="EB41_RS01505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00286"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_162783897.1"
                     /transl_table=11
                     /translation="MMAKKTDLRVQRTRKMIIEAFFKLVETKGYEAVTIQDIADEAMIN
                     RATFYAHYKDKQHLYDAIFTFTLSAFTAILDSQQLVNGNRVRVKHIEELLTQLYINIQE
                     NKSFFLTIMDNNFDEHFRKRLAEIIEEKYATIFSQLRITENDIDVPIDFVIEYMTSIFI
                     GTLHWWITSETDMTPNHLAQLVIKLVGNGHLTVLGIELEK"
     gene            4178..8425
                     /locus_tag="EB41_RS01510"
                     /old_locus_tag="EB41_00287"
     CDS             4178..8425
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002406841.1"
                     /locus_tag="EB41_RS01510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00287"
                     /product="2-hydroxyacyl-CoA dehydratase"
                     /protein_id="WP_101008415.1"
                     /transl_table=11
                     /translation="MVMRAGIDVGSTTVKLVFLNKQNQPIFTKYERHFSDVKAATERIL
                     KEGLSRIGADQPVTMSITGSGGMGLAEVLGIPFVQEVIACTRTVETIIPETDVAIELGG
                     EDAKITFFDGALEQRMNGSCAGGTGAFIDQMAVLLKTDANGVNELAKNYQTIYPIASRC
                     GVFAKTDVQPLINEGAAKEDIAASIFQAVVNQTIAGLAAGRKIKGKVAFLGGPLFFMSE
                     LRKRFIETLAIQPEDVIFPEQPQLFVAMGAALYSEDAAECTLEELIQRLVNSQATDLQP
                     SDTLPPLFNSAEDLADFRERHAQAQAKEKPLSQHTGVTFLGIDAGSTTTKVALIDEDGH
                     LLFSFYGNNQGQPLETTMTVLKSLYQQLPEEVFIGKAAVTGYGEQLIKNALKVDIGEVE
                     TMAHYKAANHFQPGVDFILDIGGQDMKAMTIKNGVLSSIQLNEACSSGCGSFIETFAQS
                     LKYNVKDFALAALESQAPVDLGSRCTVFMNSKVKQVQKEGASVGDISAGLSYSVIKNAI
                     YKVIKVRRPEELGEKIVCQGGTFYNEAVLRAFEKISGREVVRPSIAGLMGAYGAALIAL
                     DAYEIGEETTLLSLEELAAFTSEKEFTHCGLCENNCQLTVTVFSDGRQFITGNRCERGA
                     RIKIKREERKVNLVDYKYRKLFKYRPLRENKAFRGRLGIPRVLNMYENYPLWHTFFTDL
                     GFRVELSPRSNKQIYEQGLETIPSDTVCYPAKMAHGHIQALIDAQVPIIFYPGVVFEQQ
                     ETVEADNHFNCPIVQSYPDVIRNNVDAIREGQVDYRNPYLNLANEAAVAKVLAENFADL
                     GISLEEIQTALHHGYQELAAFKKEIQEKGEETLAMLTEKGQRGIVLSGRPYHLDPEINH
                     GIAEVITQEGFHVLTEDSISHLGDVQNLRVVNQWVYHSRLYAAAKVVAKTKNLELVQLN
                     SFGCGLDAVTTDQVEEIMDRSGKIYTVLKIDEGANLGAIRIRLRSLKAAVNEREKQQFV
                     PHMQMEEPEKIVFTKQMKKTHTLLLPMLSPIHQSGLVDVALQASGYHVVCLPEQDKEAV
                     NVGLKYVNNDACYPAIISIGQLVEALESGQYDLDNVSVLMTQTGGGCRATNYIPLLRKA
                     LNDAGFSQVPVVSVSMGNKGVESNPGFKFTLPMIKRLVVAFLYGDLFERVVYRTRPYET
                     EKGMVDQLHQDWLKRVEANVRNGSLTQFNHFMKKIIRTFDEIPLQEIKKPKVGVVGEIL
                     VKYSPTANNDIVRLLEEEGAEAVVPDIVGFMNYSLYNQIWKYENMGMSKQSKRLAEFAI
                     KIIELVEKPMDKALRKSVRFDGIHSIYDMAADASKILSIGNHTGEGWFLTAEMIELLKH
                     EVNNIVCMQPFGCLPNHIVGKGVVKELRRQYPQANIAAVDYDPGVSLVNQLNRIRLMMA
                     TANKLLKEENVKR"
     gene            8632..9339
                     /locus_tag="EB41_RS01515"
                     /old_locus_tag="EB41_00288"
     CDS             8632..9339
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010737976.1"
                     /locus_tag="EB41_RS01515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00288"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_002357800.1"
                     /transl_table=11
                     /translation="MVQNIPIYIQIHDKIKEDIEKGVWSIGDRLPSERELALKFDVSRM
                     TLRQAIQTLADEGILERKIGSGTYVARKKVQETMTGTTSFTEITLSQNRVPSSRTVSYF
                     VAKPSSSEMEKLQLGPEDSILRMERIRFADDIPICFEVASIPYSLVSQYGKSEITNSFY
                     KTLEAKSGHKIGHSNQTISAVQASEQIAEYLEIKRGDAILRVRQVSYFENGLPFEYVRT
                     QYAGSRFEFYLEK"
     misc_feature    complement(8652..8672)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.16"
                     /tool="antismash"
     gene            10001..11134
                     /locus_tag="EB41_RS01520"
                     /old_locus_tag="EB41_00289"
     CDS             10001..11134
                     /GO_function="GO:0008641 - ubiquitin-like modifier
                     activating enzyme activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002419798.1"
                     /locus_tag="EB41_RS01520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00289"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_002419798.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 1.6e-10,
                     bitscore: 38.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 1.5e-51, bitscore: 172.2,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKYPRIKPIYPLYQLNKERFRVGAQLGITIEFDDDEGQFWTLS
                     NLLDGVRSFDEVVTEMKRKYPELTVKDIEEGIDFLNDEGLIEETFPGRMIEDRYLANVN
                     YFSRYCKADDDRFEIQEKINNLKILLLGLGGGGSNILTLLAGLGPKMIRMVDYDRVETS
                     NLGRQLLYREADIGEKKTVVAKRAINEMNSNINVETVDKKIIDVNDVVELTEGIDIIVC
                     AIDEPPFLIHRIVNEAIVKVGLPCVFGASQVSRGRVYTVIPQKTGCFDCMNLNFSKNDP
                     KFVEQFVGFRNIQFAPPSIAYGPGIFQLTASIVDELIRVVTRYAEPKSLGTQYEINYED
                     GNSFTHKTWPRFESECPTCGKGDVSQWEIFQYYQEKK"
     aSDomain        10016..10267
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EB41_RS01520_Pantocin_Microcin_RRE.1"
                     /evalue="2.00E-12"
                     /identifier="RREFam017.1"
                     /label="EB41_RS01520"
                     /locus_tag="EB41_RS01520"
                     /protein_end="89"
                     /protein_start="5"
                     /score="38.0"
                     /tool="antismash"
                     /translation="PRIKPIYPLYQLNKERFRVGAQLGITIEFDDDEGQFWTLSNLLDG
                     VRSFDEVVTEMKRKYPELTVKDIEEGIDFLNDEGLIEET"
     gene            11098..11970
                     /locus_tag="EB41_RS01525"
                     /old_locus_tag="EB41_00290"
     CDS             11098..11970
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002382253.1"
                     /locus_tag="EB41_RS01525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00290"
                     /product="hypothetical protein"
                     /protein_id="WP_002363835.1"
                     /transl_table=11
                     /translation="MGNISILSREEIGRDYTEARTLKRKLNNGDWVYVSEENQLLVLSD
                     EVARQINSSELIEEEVLNELVENKIMIKKADQRDDYKPLFVEPKNILFKSSSFLIDVNG
                     IVAFTISIFLFVIKGSPFGSAVNVLFTNPLKFLLIAILVSIVSTTFHEFMHIIFSRNSR
                     KINLNIVKAVATIPMTHVWTWSRFGRITAITSGMSSDAIFLLVFLIMNNKSVGVNSIAA
                     SILITRILWQFIIIQKTDINILISFVVDNPFYFEEVAIMKLIIIKVISISVLAMIIWLW
                     FQPVINQFN"
     gene            11993..12937
                     /locus_tag="EB41_RS01530"
                     /old_locus_tag="EB41_00291"
     CDS             11993..12937
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002379390.1"
                     /locus_tag="EB41_RS01530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00291"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002419797.1"
                     /transl_table=11
                     /translation="MNQQLELHSLSKKYKKSESYANDNINLRFNKGEITAIAGHNGAGK
                     TTMLNQIIGITKSTKGSITFNGLSFARDSKIAREYVSMMPQLHAPLAGITMAQSVESII
                     RIRGGSQKIAEEECIKILKELKIDGWKDIPGQKLSGGLRRLTSFAMAVVYPSPIIVLDE
                     PTNDVDPIRRQKIWRYLKELSNKGHIIIVVTHNILEVEKYADRYILMNHGKVLEDKNLK
                     KQSIKINDRNYMTVNFLNLSDLKSVIVPSAIQTNINDEELMIEMELENSQVLEAVDWVM
                     KLVIERKVQNYKVSPKSLNETYGELIDENDKKL"
     gene            12915..13673
                     /locus_tag="EB41_RS01535"
                     /old_locus_tag="EB41_00292"
     CDS             12915..13673
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401516.1"
                     /locus_tag="EB41_RS01535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00292"
                     /product="ABC transporter permease"
                     /protein_id="WP_002419796.1"
                     /transl_table=11
                     /translation="MKMIKNYRRKSMIKELFALVGWSLLRHKYLLPVFTLTQVFLSLAI
                     VYGLALLIPDVNNQTAIYLSSGATTLGIIAVGCVLAAQIVSTAKQEGIVDYQRTLPVSR
                     LNILISDFIIWGMASLPGVFMSFLAAYLRFDVQIRFSMKALAILSLIQLCMISIGFALA
                     YWLTPNVVGLATQIIMIGGLLFSPITYPTDRLPSALVNFFEFLPFVPSSNLIRSLFYEQ
                     NTVNISNIIVVCFWFVLTTLLSLISLSRRD"
     misc_feature    complement(13675..13687)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: strong, score: 26.12"
                     /tool="antismash"
     gene            13682..14395
                     /locus_tag="EB41_RS01540"
                     /old_locus_tag="EB41_00293"
     CDS             13682..14395
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002417630.1"
                     /locus_tag="EB41_RS01540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00293"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002378341.1"
                     /transl_table=11
                     /translation="MQTININNLYKKVSDTFNLKVDQLDLEVGKIYGLVGPNGAGKTTL
                     MKCLCSLLRPDSGILKIDNRQVEIADPKILLQVGTNFVNSDSLNGFMLEDIYNDHAFYY
                     KLKNLLMIETLLMDVGLNVNKKRKFNTMSLGMKQRFLLGLATAHNPSLVLLDEPFNGLD
                     PDGVELFIENVKTLSENRVLIISSHILRDMETFLDDVIFIEKGNVQEPKSMVEIREEYR
                     EGLKEYYDEQKRKHD"
     gene            14367..15101
                     /locus_tag="EB41_RS16255"
                     /old_locus_tag="EB41_00294"
     CDS             14367..15101
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002419795.1"
                     /locus_tag="EB41_RS16255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00294"
                     /product="hypothetical protein"
                     /protein_id="WP_002419795.1"
                     /transl_table=11
                     /translation="MMNKRENMISDSKLNVYRYELDKIKNVWFKVFLITLVIQMLFFMF
                     FSFVGVFDESADTISSFQGIIALSNTVSMCGISIYGAVLLRKELVRFYVGNHRNRTFLF
                     PIDRKELLVKKTSSFYVIILSSFGSALLISFVTEVLLNLILKFHSSNLFFEIYLGFITI
                     VTSCSLLFVILILSEIISIWKQSEIASIITSVVLMLIYSNFSAMGLMNFPTITFLFSTI
                     MGLMLVWLFLKFSDKLCDMEVY"
     gene            complement(15123..16154)
                     /locus_tag="EB41_RS01550"
                     /old_locus_tag="EB41_00295"
     CDS             complement(15123..16154)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002379391.1"
                     /locus_tag="EB41_RS01550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00295"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_224785632.1"
                     /transl_table=11
                     /translation="MTLISINLICEVLSLHFTKIILNAELTSYGSPTFFITSITITTLI
                     GVAWIVILKFSIVKEAKSELSTNLSFIVILLPIPILSIIILFGLLIGNNNDKISEITIT
                     ISVIFLNICVIFLYKITIEYQKNQYDLTLRKKNIEVEYRILNEIKRNRTNVLKLKHDLK
                     NQYLTILGLIENEEVNEAIDYIKSSFDILEPPTKTYAADGVLNYLLNEKLAEARKNQIN
                     VDHQIFVSKNIKINNDVLTIVIGNIIDNAIQASKRIKPIDRYVNIIIKQVNNDLFIEVS
                     NNYNSEEIFTRKHRKDKGLGMKNIGDLLQQLGGIQRHWTKERRYFVTIVIFNVYKGNKC
                     GDN"
     misc_feature    complement(16355..16370)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.13"
                     /tool="antismash"
     gene            complement(16433..17137)
                     /locus_tag="EB41_RS01555"
                     /old_locus_tag="EB41_00296"
     CDS             complement(16433..17137)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002399975.1"
                     /locus_tag="EB41_RS01555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00296"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_002399975.1"
                     /transl_table=11
                     /translation="MKVAICDDNPTLTEKINTMLFNYNPNIFETYTYYNPLKLVNQLDQ
                     ENFDFFILDIEMSEMSGIDLAKKIRERDILSPIVFLTSYKEYMEEVFQVQTFDYLLKPP
                     TEDRLHQVLEKLRQQLEKKRNYFVFSSNKVTYKIPTKDIIYFEKDKRQVLIHTVGEIYK
                     PYMSTNQINEQLDTNFVQVHSSFIINCAYIKELGKNFLLMDSKEKCIEIPISRRFKAAA
                     HKSIVMSMRGKI"
     misc_feature    complement(17546..17560)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.98"
                     /tool="antismash"
     misc_feature    17618..17628
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            17622..18053
                     /locus_tag="EB41_RS01560"
                     /old_locus_tag="EB41_00297"
     CDS             17622..18053
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002419793.1"
                     /locus_tag="EB41_RS01560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00297"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_002419793.1"
                     /transl_table=11
                     /translation="MLQKYIEILTRDEAIFRKKPDGTEVNYFLFPEFEIHINSLPGKTV
                     QGWHRHHEIEEVLLVQSGKVKIEELENQQIISRICAGGELIRMHNSLHRISNPDTLSAS
                     FTVFRFVPQGQNQQECIKNDKEEFSDAAVQRLLKINDSL"
     gene            18222..19136
                     /gene="trxB"
                     /locus_tag="EB41_RS01565"
                     /old_locus_tag="EB41_00298"
     CDS             18222..19136
                     /EC_number="1.8.1.9"
                     /GO_function="GO:0004791 - thioredoxin-disulfide reductase
                     (NADP) activity [Evidence IEA]"
                     /codon_start=1
                     /gene="trxB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016617920.1"
                     /locus_tag="EB41_RS01565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00298"
                     /product="thioredoxin-disulfide reductase"
                     /protein_id="WP_002357780.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.3e-56, bitscore:
                     187.7, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 1.2e-07, bitscore: 28.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYDVIIIGAGPAGMTAALYASRSNLSVLMIERGAPGGQMNNTAEV
                     ENYPGFDSIMGPELAYKMYENVEKFGTENAYGIVMGIEDHGSYKEVICDDKSYEAKAVI
                     IATGCEHRKLGVKGEEEFAGRGVSYCAVCDGAFFKNKRLVVVGGGDSAVEEAIYLTQFA
                     SEVVIVHRRDELRAQKIIQDRAFANEKISFVWDTVVEEIVGNEMVVTGVKARNVKTDEV
                     SEIEANGVFIYVGLDPLTEPFKKAGITNEAGWIETDQEMRTKIPGVYAIGDVREKTLRQ
                     ITTAVGEGGIAGQQVFNYIEELK"
     gene            complement(19178..19639)
                     /locus_tag="EB41_RS01570"
                     /old_locus_tag="EB41_00299"
     CDS             complement(19178..19639)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002419792.1"
                     /locus_tag="EB41_RS01570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00299"
                     /product="hypothetical protein"
                     /protein_id="WP_002419792.1"
                     /transl_table=11
                     /translation="MVYTVDFKEVATLGLESSPVAPVLAGLRANEARYFWNKYKHRFTT
                     VPASEAPETLAWIEKILLERELHFPYKPLEISSFTLDGIKMAYVFYENGLAVNVMYTLA
                     DEGKRAVGFKLSDGMAIPAEFEGKFKFARQKSKLAGTIRGSYFGIKGTY"
     gene            complement(19836..20336)
                     /gene="camE"
                     /locus_tag="EB41_RS01575"
                     /old_locus_tag="EB41_00300"
     CDS             complement(19836..20336)
                     /codon_start=1
                     /gene="camE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002358931.1"
                     /locus_tag="EB41_RS01575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB41_00300"
                     /product="plasmid sex pheromone cAM373 precursor"
                     /protein_id="WP_002419791.1"
                     /transl_table=11
                     /translation="MLKKPFLLFFSLLGAIFILASCGIGKDAVTDTKYKVSLQQAAEIY
                     EKEAGNSKPLVNVQFDTKPESDYSYIFTNDTETLYVNPETGKVTKNTEANQLGENETAF
                     SAAEVKELGAVNDVLSKAKKEVGGLSPRILTWKLTKNNNKLVYTVDVKTTTADEKVTLD
                     ANK"
ORIGIN
        1 cgttgaagtt gatttaatta tgttttcgcc aattattcat tggccaagtt atctatattc
       61 cgcagtcatc accatgtgtt tcacgttgtt tgtgatggtc attatgcatc ggaaattgaa
      121 gaaaatcaat atgattgaag cgttaaaatc aaatgaatag cacattttaa aaaacgagga
      181 gtccgtagaa gttcgataat tctagggctg ctcgtttatt gttgcttctt ttattaagaa
      241 aaaataggtc ttaagatgta tcttttgaga tttatttgga aattactact ctttttattt
      301 aaaaattggt acactattac taggttatag cacagaaagg agtgtgggaa aagtgttaga
      361 aggtctacca ttggaaacgg tttattttta tgcattagtg gggagcgcgg tcctcgcttt
      421 tttactaatt atttttgggg atgtttttaa ttttgatgga ccggttgacc caatgctgat
      481 tattccatgg attgctttta cctcgctgtt tgggtacctt ggggaagaat taacagcggt
      541 gaatagttgg cttattttaa ttgtcagtgg tattctttca accattattg ttttcttcct
      601 aaatttttat gtgttggtcc ctttgaaaaa ttcagaggcc acaatttcta tttcggaaaa
      661 agacatggag ggtcgtgttg ctactgtgat taccccaatt cctgtccggg gaatgggcga
      721 gattcaattg aagagtgtca caggttcgtt aagtcgacca gcagcatttt atgtgccaca
      781 agaagtggct gcgccaagag gtagtgaggt attgattatt gaattgaaag aacgggtttg
      841 ttatgtcatt ccttacgaag gcagtctaaa aatatagagt aggagagaag aaaatgggaa
      901 ttttgttacc gattattatt gcagttttag tattattaat gttattaatt gtgtttgttt
      961 ctaaatatca gaccgccaaa cctgatgaag cgttaattat cagcgggagc tatctaggct
     1021 ctaaaaatgt tcatgtagac gaaggtggca acaaaattaa aatcgttcgt ggcggtggtg
     1081 cgtttgtctt accagtgttc caacgttcaa atcgaattag tttgctttca agtaaattag
     1141 atgtttctac accagaagtg tatacagaac aaggggttcc tgtaatgtgt gatggaacat
     1201 caatcattaa aattggttcg tcggttgaag aaattgcgac agcagcggaa caatttttag
     1261 gaaaaacaac ggaagaatta gaaaatgaag cacgtgaagt attagaagga catttacgtt
     1321 cgattttagg ttcaatgaca gtggaagaaa tttaccaaaa tcgtgataaa tttagccaaa
     1381 gtgtacaaga agttgccagt gttgacttag ctaaaatggg cttagttatt gtgtcgttca
     1441 caattaaaga agttcgtgat aaaaatggat acttggattc attagggaaa ccaagaatcg
     1501 ctcaagttaa acgtgatgca gatattgctg aagcagaagc tttgaaagaa actcgcatca
     1561 aaaaagcgga agcagaaaaa gaatcacaac aagcggaatt gcaacgtcaa acagaaattg
     1621 cagaagcttc aaaagaaaaa gaattgaaat tagcgttata caaacaagaa caagacattg
     1681 ccaaagccaa agcagaccaa gcctataact tggaaagcgc gcgtgcacaa caacacgtgg
     1741 tggaacaaga aatggaagtc aaagtcgttg aacgtcaaaa acaaattgag ttagaagaaa
     1801 aagaaattac gcgtcgtgaa aaacaatacg actcagaagt gaagaaaaaa gccgatgcag
     1861 atcgttatgc acgcgaacaa gaagctcttg ctcaaaaagc acgcgaagtg gcagaagccg
     1921 aagcagaacg tttcaaagtt gaagcattag ccgaagcgga agccaacaaa acgcgtttaa
     1981 caggtcaagc gcaagccgaa gctattttag ctcgtggtgc agcggaagcc gaagccaaac
     2041 aaaagattgc tgatgccttt aaagaatatg gtgaagcagc tgtgttaagt atggtgatgg
     2101 aaatgttacc acaattaatg aaagaagcag cacaaccatt gggcaacatt gacaagattt
     2161 cagtggtaga tacaggcgca ggtggcgaaa attctggcgc caaccgtatt accaattatg
     2221 caacaaactt gttggctggt acacaagaaa cactaaaaga aacaacgggc ctcgacgtga
     2281 aagagctaat tgaaaacttt tctaaaaaag gtacctcaaa tagcgtgaac tatcatgcaa
     2341 cagaaggttc agaaaaagaa tagaaatcag cctttaagga gtagcgaatc gcatttcgtt
     2401 actccttaat gctgcattga aacgataaac aaacaatctg acagagaaat agcgggtgct
     2461 tgttttgttt caaagattct gataacatag agttcttgga gggatagaga tgtcaaaaaa
     2521 gaataaagat attgaagtac gtgttgaaga agaaaaagcc caatacaatg gagcaaatgt
     2581 tttaatgaac aaattattta ttggtaaaaa agaaatcggt cgtgttattc cgcaaaatga
     2641 taaaaaattc atcattgaaa ttgatggcaa gcaagaaggt acagcaaaaa atctggacga
     2701 agcctttgaa acaattattc gtcaatggaa tttaagtgaa taaaaaataa ataacaattt
     2761 tttttaaaaa agggttgctt ttttctggaa aagattgtat tataactaag tcaggtcgtt
     2821 acagcgacaa tgactttttg gaggaatagc gaagtggcta aacgcgacgg actgtaaatc
     2881 cgttccttag ggttcagtgg ttcgaatcca ctttcctcca ttttcttttt ggggtatagc
     2941 caagcggtaa ggcaacggac tttgactccg tcatgcgttg gttcgaatcc agctacccca
     3001 gttttcagaa catttctggt agagagatgt tctttttttg tataattata taacaaaaat
     3061 gaggtaagat tttcctcatg tacaggctag aaaagttttc atttatataa gaatatgcta
     3121 aagtataaag aaagaatagt ctggagttga taagaatgaa ctttaaagaa aaaattacag
     3181 aaatggttga aaatgtttac gatttagcac gcgatggtaa gtatgatgtc aaagttgact
     3241 taattcctcg taaaaaaggc aacatcaaaa gtggtgttaa agtcacttct tcaagaaata
     3301 cagcccacaa tatcaaatgg cgttcaaaaa actaactcgt ctttaacaga aacaccggag
     3361 cagacaaaat tattgtctac tccggtgttt ttatttttct aattcgatgc ctaagacagt
     3421 taaatgccca ttaccaacta atttgataac taattgggct aagtggttgg gtgtcatatc
     3481 cgtttcgcta gtaatccacc aatgaagggt accgatgaag atagaggtca tgtattcaat
     3541 aacaaaatct atcggtacat caatatcatt ttcggtaata cgcaactgcg aaaaaatcgt
     3601 cgcatatttt tcttcgataa tctcagctaa gcgttttcga aagtgttcgt cgaaattatt
     3661 gtccatgata gttaagaaga aagatttgtt ctcttgaatg ttgatgtaga gttgcgtcag
     3721 aagttcttca atgtgcttca cgcggacacg gttgccatta accagttgtt gcgaatcaag
     3781 aatagcggta aaagcactaa gcgtaaaggt gaagattgca tcatataaat gctgtttgtc
     3841 tttataatga gcataaaaag tcgcacgatt aatcatagct tcatcagcaa tatcctgaat
     3901 cgtcaccgct tcgtagcctt tcgtttctac aagtttaaaa aaagcttcaa taatcatttt
     3961 tctggttcgt tgtactctaa ggtctgtttt ctttgccatc ataaattcct ttcgagatag
     4021 tcaacattcg cggaaacttt gttgtttatc tcacaaaata gggtaaattg cttgttgcaa
     4081 atcatttaga acctttctaa aataggtata tctattataa caaacagttt gtataataat
     4141 caacaaactg ttgggaaatg aaggggtatt ttaattgatg gttatgagag cagggattga
     4201 tgttgggtca acgacagtaa aattagtatt tttaaataaa caaaatcagc ctatttttac
     4261 aaaatatgaa cgccattttt cagatgtcaa agcagcaacg gaacgcattt taaaagaagg
     4321 gctatcaagg atcggtgcag accaacctgt gacaatgagc ataactggct ctggtggtat
     4381 ggggctggct gaggtattag ggattccctt tgttcaagaa gttatcgcgt gtacacgaac
     4441 tgttgaaaca ataatcccag aaacggatgt tgctattgaa cttggcggag aagatgcaaa
     4501 aatcactttt tttgatggtg ctttagagca acgaatgaat ggtagttgtg caggtgggac
     4561 aggcgccttc atcgatcaaa tggctgtttt acttaaaacg gatgccaatg gagtgaatga
     4621 attggcgaag aattatcaaa ctatttatcc gattgcttcc cgctgtgggg tttttgccaa
     4681 aacggatgtt caacctttaa tcaatgaagg agcagcgaaa gaagatatcg cggcgagtat
     4741 ttttcaagcg gtagttaatc aaacaatcgc tgggttagct gctggtcgca aaattaaagg
     4801 taaagtagcg tttttagggg gacccttatt tttcatgtca gaattgagaa aacggtttat
     4861 tgaaacctta gcaattcagc cagaagatgt tatttttcca gaacaaccgc aactgtttgt
     4921 agcaatgggt gcagcacttt attcagaaga tgcagccgaa tgtacattgg aagaattaat
     4981 tcagcgctta gtgaacagcc aggctactga tttacagccg agcgacacgt taccaccgtt
     5041 atttaacagc gcagaagatt tagcagattt tcgagaaaga cacgcgcaag cccaagcaaa
     5101 ggagaaacct ttatctcaac atactggcgt gaccttttta gggattgatg caggctccac
     5161 aacgacaaaa gtcgcattga ttgatgaaga tggccatttg ttgttttctt tttatggtaa
     5221 taaccaaggg caacctttag aaaccaccat gacagtactg aaatcacttt atcaacaact
     5281 gcctgaagaa gtttttatcg gaaaagcggc tgttacagga tatggagaac agctaataaa
     5341 aaatgcgtta aaagtcgata ttggtgaagt tgaaacgatg gcccattaca aagcagccaa
     5401 ccattttcag ccaggtgtgg attttatttt ggacatcggg gggcaagata tgaaagcgat
     5461 gaccattaaa aatggcgtgc tttcctccat tcaattaaat gaagcttgtt cttctgggtg
     5521 cggttctttt atcgaaacct ttgcgcaatc tttaaaatat aatgtgaagg attttgcttt
     5581 ggcggcttta gaatcgcaag cgcctgttga tttaggttct cggtgtactg tttttatgaa
     5641 ctcaaaagtg aaacaagttc aaaaagaagg ggcctctgtc ggcgatattt ctgctggact
     5701 atcttattca gtcatcaaaa atgccattta taaagtcatt aaggttcgcc gacctgaaga
     5761 gttgggagaa aagattgtct gccagggagg aacattttac aatgaagcgg tcttgagagc
     5821 ttttgaaaaa attagcggtc gtgaagtggt tcgtccatct attgctggtt tgatgggggc
     5881 ctatggagca gcgctgattg ctttggacgc ttatgaaatt ggggaagaaa ccacgcttct
     5941 ttctttagaa gagttagcgg catttacctc tgaaaaggaa tttactcatt gcggcttgtg
     6001 tgaaaacaat tgtcaattaa cggtcacagt gttttcagat gggcgccaat ttattacggg
     6061 aaatcgctgt gaacgtggtg cgcgaattaa aattaaacga gaagaacgca aagtgaattt
     6121 ggttgattat aagtaccgca agttatttaa gtaccgacct ttgcgggaaa ataaagcgtt
     6181 tcgtgggcgc ttgggtatcc ctagagtcct aaacatgtat gaaaattatc ctttgtggca
     6241 tacatttttt actgacttgg gctttcgggt cgaattatcg ccacgttcta ataagcaaat
     6301 ctatgagcaa ggccttgaaa cgattcccag tgatacggtt tgttacccag cgaaaatggc
     6361 gcatggacat attcaagcat taattgatgc gcaagtgcca attatctttt atcctggtgt
     6421 tgtttttgaa cagcaagaaa cagtggaagc ggataatcat tttaattgtc caattgtgca
     6481 aagctaccca gatgttattc gaaataatgt ggatgccatc agagagggcc aagtggatta
     6541 tcgaaatccc tatcttaatt tagcgaatga agctgcagtt gccaaagttt tagctgaaaa
     6601 ttttgctgat ttagggattt ccctagaaga aattcaaaca gcgctgcatc atggttatca
     6661 agaattagca gcttttaaaa aagaaattca agaaaaaggc gaagaaacgt tagccatgtt
     6721 aaccgaaaaa ggccagagag gaattgtctt atcgggacga ccgtatcact tggatccaga
     6781 aattaatcac ggcattgccg aagtcattac acaggaagga ttccatgtct tgacagaaga
     6841 cagtatctcg catcttggag acgtgcagaa tttacgtgtg gtgaatcaat gggtctatca
     6901 ttctcgctta tatgcggcgg ctaaagtagt ggctaagacg aaaaatttag aacttgtcca
     6961 actgaattcc tttggttgcg gcttagatgc tgtgacaacc gatcaagtag aagaaatcat
     7021 ggatcggtct ggcaaaattt atacagtcct caaaatcgat gaaggcgcga atttgggcgc
     7081 aattcgtatt cggttgcgct ccttgaaagc ggctgtcaat gagcgggaga agcaacagtt
     7141 tgttccgcat atgcaaatgg aagagccaga gaaaatagtg tttacaaaac aaatgaaaaa
     7201 aacacatact ttactgttac caatgcttag cccgattcat caatctggat tagtcgatgt
     7261 agcattacaa gcttctggct atcatgtcgt ctgtttgcct gagcaggata aagaagccgt
     7321 gaatgtcggg ttaaaatatg tcaataatga tgcatgttac ccagcaatta tttctatcgg
     7381 acaactagtc gaagctttgg aaagtggtca atatgatttg gataatgtca gtgttttaat
     7441 gacgcaaacg gggggcggtt gtcgcgcaac gaattacatt ccattattaa gaaaagcctt
     7501 aaatgatgct ggtttttctc aagttcctgt agtttcagtt tcgatgggta ataaaggggt
     7561 cgaatccaat ccaggattta aatttacgtt gccaatgatc aaacgcttag tagttgcctt
     7621 tttatatggt gacttattcg aacgagtagt ttatcgaaca agaccttatg aaacagaaaa
     7681 aggaatggtg gatcaactgc accaagattg gctaaaaaga gtggaagcca atgtccggaa
     7741 tggttcgctg acacaattta atcacttcat gaaaaaaatt attcggacgt ttgatgaaat
     7801 tcctttacag gagataaaaa aaccaaaagt cggtgtggtc ggggaaattt tagtgaaata
     7861 ttcgccgaca gcgaataatg atattgtgcg tttgctagaa gaagaaggtg ctgaagcagt
     7921 tgtgccagat attgttggct ttatgaacta ttctttgtac aatcaaattt ggaaatacga
     7981 aaatatgggc atgtcaaaac aaagcaaacg tttagcagaa tttgcgataa aaatcattga
     8041 attggtagaa aaaccaatgg ataaggcatt gagaaagtcg gtccgttttg atggcattca
     8101 ttccatttat gatatggcag cagacgcaag taaaatttta tcaattggca atcatacggg
     8161 tgaaggttgg tttttaacag ctgaaatgat tgagctctta aaacatgagg tgaataacat
     8221 cgtttgtatg cagccgtttg gatgtttacc aaaccatatt gttggaaaag gggtcgtgaa
     8281 agagctacga cgtcaatatc cgcaagcaaa cattgcagcg gtggattatg atccaggggt
     8341 atctttggtc aatcagttga accgaatccg tttgatgatg gccacagcga acaagttact
     8401 gaaagaagaa aatgtaaaaa gataataact aatagaaatt cgtttaaaaa catttggctt
     8461 ggtcactttt tactgactaa gccaaatgtt tttgttataa aaagaaagca tgcaactaga
     8521 ccaactttga taaaaattcc aattcctctt ttatttatca ttttttagtt gtttacacgg
     8581 tctataccag ttataataga agaggagatg aacgaagagg aggaagcgta aatggttcaa
     8641 aatataccaa tttatattca aattcacgat aaaatcaaag aagatattga aaaaggtgtc
     8701 tggagtatcg gggatcgttt gccctctgag cgagaattag ccttgaaatt tgatgttagt
     8761 cgaatgacct tacgccaagc cattcagact ttagcagacg aagggatttt agaacgaaaa
     8821 attggttcag gaacgtatgt agcacgtaag aaagttcaag aaacaatgac tggtaccact
     8881 agttttacag aaattacctt gtctcaaaat cgcgttcctt ctagtcggac ggtgtcttat
     8941 tttgtagcga aacctagttc tagtgagatg gaaaaattac aactaggtcc agaagattca
     9001 attttacgaa tggaaagaat tcggtttgcg gatgacattc cgatttgttt tgaggtggcg
     9061 agcattcctt attcattggt ctcgcaatat ggcaaatctg aaatcacgaa ctctttttat
     9121 aaaactcttg aagctaaatc tggccacaaa attggccatt ctaaccaaac aatctctgct
     9181 gttcaagcat cggaacagat cgcagaatac ttagagatta aacgaggcga tgcgattctg
     9241 cgtgtgcgcc aagtatccta ttttgaaaac ggactacctt ttgaatatgt tcgtacgcag
     9301 tatgcaggaa gtcgatttga gttttattta gagaagtaga gaaatgataa gtatggaaaa
     9361 atgccgagga ataggctgag gtaagatatt ttaaccccca aaagttgtat ctgaaaaata
     9421 caatttttgg aggttatttt tatgaactta taaggtagaa ttcaaattaa aattagtgaa
     9481 agcatctcca ttcaaataaa tattgaatag agtagcaagt ctgaatacca gaaaagtgag
     9541 atggtttgtc ccgctataaa tattgttaaa aataaactta taatagctgc tagtttattt
     9601 gcttctgttc tttttttggc tgtagttcgt tcttgtccat tttttatatt tcttttttaa
     9661 actgtaacct aatataagat atacccgttc aacgctttaa tcaaaaagtt gcaaaattat
     9721 cagttgtttt gcaaattgtt acattgaaat tgttaattat taccaatcaa taatacttat
     9781 gattgtcaaa gttattatat agatatactg aaagagaaat ttattttctt tttcaataaa
     9841 aagtttagcg gaaggagtga tgcggaatga aaaaaattaa cgtacgtaaa gccgatacag
     9901 ttgatgcaac agcatggtgg attattatct aatttgataa ccaaataacg gttagacgag
     9961 atagaaatat ctcgtcattt tttaataagg agtgaaaaaa atgaagtata aatatcccag
    10021 aataaaacca atctatccat tgtatcaatt aaataaagag agatttagag ttggggccca
    10081 attaggaatc actattgaat ttgatgatga tgaaggtcaa ttttggacat tatctaattt
    10141 actcgatgga gttagatcat ttgatgaagt tgtcacagaa atgaagagga aatatccgga
    10201 attaacagta aaagatatcg aagaagggat agatttttta aatgatgaag gtctaatcga
    10261 ggagacgttt cctggtagaa tgattgaaga tagatactta gctaatgtga attactttag
    10321 taggtactgt aaagctgatg atgatagatt tgaaatacag gaaaagataa ataacttgaa
    10381 aatactatta ttaggtcttg gtggaggagg atcaaatatt ctaacgttac tagcgggtct
    10441 tggccccaag atgatcagaa tggtggacta tgaccgagtt gaaacaagta atttaggtcg
    10501 tcaattacta tatagagaag cagatattgg tgagaagaaa actgtagttg ctaaaagagc
    10561 cattaatgaa atgaactcaa atattaacgt tgaaactgta gataaaaaaa taatagatgt
    10621 gaatgatgtt gttgaattga cagaaggaat agatatcatt gtttgcgcta ttgatgaacc
    10681 ccctttcctt atacatagaa ttgtgaatga agctattgta aaagttggtt tgccgtgcgt
    10741 gtttggtgcc tcacaggtta gccgaggaag agtatacact gtaatacccc agaaaacagg
    10801 atgctttgat tgcatgaatt tgaacttcag taaaaatgac cctaaatttg ttgaacaatt
    10861 tgtaggtttt agaaatattc aatttgctcc cccatccata gcttatggtc ctggtatctt
    10921 tcaattaaca gcatcaattg tagatgagtt aataagagtg gtaacaagat atgctgagcc
    10981 aaaaagtttg ggaacgcaat atgaaattaa ctatgaggac ggaaactcgt tcacacataa
    11041 aacttggcca aggtttgaga gtgaatgtcc aacttgtggt aaaggagatg tctcccaatg
    11101 ggaaatattt caatattatc aagagaagaa ataggccgag actataccga agctcgtacg
    11161 ttaaaacgta agctaaacaa tggcgattgg gtttatgtat cagaagaaaa tcaactatta
    11221 gtgttgagtg atgaagtggc gagacaaatt aattcatccg aactaatcga agaagaggta
    11281 cttaatgaat tagttgaaaa taaaattatg ataaaaaaag ccgatcagag agatgattat
    11341 aagccgctat ttgtcgagcc taagaatatc ttatttaaaa gctcctcttt cctgattgat
    11401 gttaacggta ttgttgcgtt tacgattagc atatttttat tcgtaatcaa ggggtctcct
    11461 tttggaagtg cagtaaatgt tttgtttaca aatcctttaa aatttcttct aattgctatt
    11521 cttgtctcaa tcgtatctac aacttttcat gaatttatgc acattatatt ttcaaggaat
    11581 tcaaggaaaa tcaatttaaa catagttaaa gccgttgcta cgatacctat gactcatgta
    11641 tggacgtgga gtaggtttgg tagaatcacg gcgatcacct ctggaatgtc gtcggatgca
    11701 atattcttgt tagttttttt gattatgaat aataaaagtg ttggagttaa ttctattgcg
    11761 gcatcaatac ttataacaag gatattgtgg caatttatca ttatacaaaa aacagatatt
    11821 aacattttga tttcttttgt ggttgataat cctttctact ttgaagaggt cgcaattatg
    11881 aaattaatca ttattaaagt aataagcata agtgtgctag caatgataat ttggttatgg
    11941 ttccaacctg ttatcaatca atttaattaa gtctaaatat aggaggtttg ctttgaatca
    12001 acagttagaa ttacattcgc taagtaaaaa gtacaagaaa tcagagagct atgcaaatga
    12061 taatataaat ttgcgcttta ataaaggtga aataactgcc atagctggac ataatggcgc
    12121 tggtaaaaca acaatgttga atcagattat aggtataacg aaatcaacaa agggctctat
    12181 aacatttaat ggtctatcat ttgcgagaga tagtaaaatt gcaagagaat atgtctctat
    12241 gatgcctcaa ctacatgctc ccttggcagg tataacgatg gctcaatctg tcgagtcaat
    12301 aataagaata agaggaggca gtcagaaaat agctgaagaa gagtgtatta aaattttaaa
    12361 agaattaaaa atagatggat ggaaagatat accaggacag aaactttcag gcggacttag
    12421 aaggctcact tcatttgcaa tggccgttgt atatccttct ccaataatag tccttgacga
    12481 acctactaat gatgtggatc ctattagacg gcaaaaaata tggagatatc tgaaagaatt
    12541 atctaataag gggcatataa tcatcgtggt cacacacaat attttagaag ttgaaaaata
    12601 tgctgataga tatattctaa tgaatcatgg aaaggttctt gaggataaga acttaaaaaa
    12661 acagtctata aaaataaacg atcgaaatta tatgactgtt aactttctta atctaagtga
    12721 tttgaagagt gtaatagtac cgagtgcaat tcagactaac ataaacgatg aggaattaat
    12781 gatagaaatg gaattagaga acagtcaagt gttagaagca gttgactggg tcatgaaatt
    12841 agtaatagaa agaaaagttc aaaattataa agtttcccca aaatccttaa atgaaaccta
    12901 tggagagtta atagatgaaa atgataaaaa attatagaag aaaatcaatg attaaggaat
    12961 tatttgcttt agtagggtgg agtttattaa gacataaata cttattgcct gtttttacat
    13021 taactcaagt atttctatca ttagcaattg tctacgggtt agcacttcta ataccagatg
    13081 tgaataatca gacagctatc tatctgtcat ctggagcaac tactcttggg attattgcgg
    13141 tagggtgcgt tcttgctgct caaatagtaa gtacagcaaa acaggagggc attgtggact
    13201 atcaaaggac attgccagtt tctcggttga acatattaat ttccgacttt ataatttggg
    13261 gaatggcctc actacctggg gtgtttatgt catttttagc ggcatattta agattcgatg
    13321 tccaaattag attctcaatg aaggccctag ctattcttag tctaattcaa ttatgtatga
    13381 tctctatagg ttttgctttg gcatattggt taacacctaa tgtagtagga ttagcaactc
    13441 agataattat gataggtgga cttttattct cgcctattac ttatccaaca gatagattgc
    13501 cttctgcttt agtgaacttt tttgaatttt taccatttgt tccatcgagt aatttgataa
    13561 gatcactgtt ttatgaacag aatactgtta atatttctaa tattattgta gtttgttttt
    13621 ggttcgtgtt aactacatta ctttcactta tttcattgtc aagaagggac tgaattgcaa
    13681 aatgcaaaca ataaatataa ataatttata taaaaaagta agtgatacat tcaatttaaa
    13741 ggttgatcaa ttagatttag aagtagggaa aatttatgga ttagttggtc cgaatggtgc
    13801 aggtaaaaca actttgatga aatgtctatg tagtttgctt agacctgata gtggaatact
    13861 taaaatagac aatcggcaag tagaaatagc agaccctaaa atattattgc aagtgggtac
    13921 taactttgtt aactcagata gtttaaatgg atttatgctt gaagatatat acaatgacca
    13981 tgctttttat tacaagttaa aaaatttgtt aatgatagag actctattaa tggatgttgg
    14041 tctaaatgta aataaaaaaa gaaagtttaa tacgatgtct ttaggaatga aacaaaggtt
    14101 tttgctaggt cttgctacag ctcacaaccc ttcattagta ttattagatg agccatttaa
    14161 cggtttagat cctgatggtg tagagttatt tattgagaat gttaagacct tgtccgaaaa
    14221 tagagtgttg ataattagta gtcatatatt gagagatatg gaaacatttc ttgatgacgt
    14281 tatatttata gagaaaggca atgtacaaga accaaaatca atggttgaga ttcgagaaga
    14341 gtatagagag gggttgaaag agtattatga tgaacaaaag agaaaacatg attagtgact
    14401 caaaattgaa tgtttataga tatgaattag ataaaattaa aaatgtttgg tttaaagttt
    14461 tcttaattac actggtaatt caaatgttat tttttatgtt tttctcattt gtgggagtat
    14521 ttgatgaaag tgctgatacg atctcgtcat ttcaaggaat tatagcatta tcgaacactg
    14581 tttctatgtg cggcatatca atttatggag ctgtattact aaggaaagag cttgtacgat
    14641 tttatgttgg caatcaccgg aatagaacgt ttctttttcc gattgatcga aaagagcttc
    14701 tcgtaaaaaa aacaagttct ttttacgtga taatcttatc tagctttgga agtgcgcttc
    14761 ttatttcatt tgtgactgag gttttgctta acttaatttt gaagtttcat agttcaaatt
    14821 tattttttga aatttacctt ggttttatta ccatagttac aagttgtagt ctactattcg
    14881 taattttgat attgtcagaa ataatttcaa tttggaaaca atcggaaatt gcttcaataa
    14941 taacgtcagt ggtactaatg ctaatatatt cgaatttttc tgctatgggt cttatgaatt
    15001 ttccaactat aacgttccta ttttcaacga ttatgggatt gatgcttgtt tggttatttt
    15061 tgaaattttc tgataaatta tgcgacatgg aagtatacta acaaatgcgg tgatttactt
    15121 gattagttat caccgcattt gtttcctttg tatacattaa atataactat agttacaaaa
    15181 tatctacgtt ctttcgtcca gtgacgttga ataccaccta attgttgtaa gagatcacca
    15241 atgtttttca ttcctaaacc tttatctttt ctatgttttc ttgtaaaaat ttcttcagaa
    15301 ttatagttat tagatacttc aataaataaa tcattattga cttgcttgat aattatattg
    15361 acatatctgt caatcggctt gattctcttc gatgcttgta tggcgttatc aattatattt
    15421 ccaattacaa tagttagaac gtcattatta atttttatat ttttagagac aaatatctga
    15481 tgatcaacat taatttgatt ctttcttgct tcagcaagct tttcattcaa taggtagttt
    15541 aatactccat cggcagcata agtttttgtt ggtggttcta aaatatcaaa actactctta
    15601 atataatcga tagcttcatt aacttcttca ttttcgataa gtccgaggat tgttaagtat
    15661 tgattcttca aatcatgttt taattttaaa acgttagttc tgtttctctt tatttcattt
    15721 aaaattctat actccacttc gatatttttt tttctcaaag taagatcata ttgatttttt
    15781 tgatattcta tagtaatttt ataaagaaaa attacacaga tgtttaaaaa tatgacacta
    15841 atcgtaatag taatctcaga aattttgtca ttgttgtttc ctattaaaag cccaaataaa
    15901 atgattattg atagtatggg aataggtaat aaaatcacaa taaatgataa gtttgtcgat
    15961 aattcagact ttgcttcttt aactattgaa aatttaagta tgactatcca ggctacccca
    16021 atcaaagttg taattgttat tgaagttatg aaaaaagtag ggctaccata ggatgttaat
    16081 tctgcattta aaattatttt cgtaaagtgt aacgacaata cttcacagat taaatttatt
    16141 gatataagtg tcattgtcca tacggccgag tcgagataag ggactgagtg tagcatagca
    16201 atagtgtaag ttaaaatgaa acttagtaat aagttaagat acggtaaata aatgttcggt
    16261 atgtaagcat tggataatat aatcgtaacc atggctgata tgattataac aatccagatg
    16321 acattataaa attctctatg atttttaata gctgttgacc aattagaaaa aaaataagag
    16381 ataagaaata aataaactaa caaacttagg cttcgtaatg ttatatcaag cattatatct
    16441 ttcctctcat ggacataact atacttttat gagcggcggc tttgaagcgc ctacttattg
    16501 gtatttcaat acatttttct ttagaatcca ttaataggaa attttttcct aactctttta
    16561 tataagcgca atttattatg aaagaagagt ggacttgcac aaaattcgta tcaagttgtt
    16621 cgtttatctg attcgttgac atatagggtt tgtagatttc tccaactgta tgaatcaata
    16681 cttgtctttt atctttttcg aaataaatga tatctttggt tggtatttta taagtaactt
    16741 tgttactaga aaatacaaag taatttcttt ttttttctag ctgttgtctc agtttttcca
    16801 aaacttggtg caaccgatct tccgtaggcg gtttcaataa ataatcaaaa gtttgtactt
    16861 ggaagacttc ttccatgtat tctttgtaac tcgtcaaaaa aacgataggt gataaaatat
    16921 cacgttctcg gatttttttt gccaagtcta ttccgctcat ttcactcatt tctatatcta
    16981 aaataaaaaa gtcaaaattt tcttggtcaa gttgattgac taacttgaga ggattgtagt
    17041 aggtataggt ttcaaatata tttgggttat aattaaatag catcgtgttt attttttcgg
    17101 ttaacgttgg attgtcatca caaatagcaa ctttcaacaa taaaacctcc tttttttcat
    17161 tctatatata ttatgaatta aattatcttt aaaaacaatc atttttttgt tagcacaact
    17221 gataaaccga cataagtaat ctggataaaa atatcaaaaa ttcagcttac tgacaaacat
    17281 ttaattagca tctaaaaaat aatcatgtaa attaaatgaa cagcgaaagc atcagttaga
    17341 gtgctatcaa tttttttaaa tctacatatg attaaaactt gatgctataa tgctagtagt
    17401 aaggttaatg tataccatag cggtacttga gaagagtaga agtgtttctg atgaacagat
    17461 ggattagtgg atattgatac tgaacagtca attgtttaaa aaagtgattt tcaaacggta
    17521 acaaaagtat atttaaagga acttgaattt tcagaaagta gcttcaaact tagtttgaaa
    17581 gaatagcttt cggctataaa aaaagttaaa aggagcctgc catgttacag aaatatatag
    17641 aaattttaac aagagacgag gccatctttc gtaaaaagcc agatggaaca gaagtaaatt
    17701 attttctatt tccagagttt gaaatacata taaatagctt gccaggaaaa actgtgcaag
    17761 gttggcatag gcatcacgaa atcgaagaag ttttacttgt gcagtcggga aaagtgaaaa
    17821 tagaagagct agaaaatcag caaattattt caagaatttg tgcaggagga gaacttattc
    17881 ggatgcataa tagtcttcat cggattagta atcctgatac gttatctgca tcatttacag
    17941 tatttcgttt tgttccacaa gggcaaaatc aacaagaatg cataaaaaat gataaagaag
    18001 aattctctga tgcggcagta caacggcttc taaaaataaa tgattcattg tgatcgttat
    18061 ttttaaactt ttcttttccc cctcctagaa aacacaaaac cgtggtacaa taacttacgt
    18121 aatagacaca cctactccga atgtcaaaaa agggcagaaa agtagacaag aaattgttta
    18181 aggagtaaag taaacttact taaaattttg ggggaaataa aatgtatgat gtaattatca
    18241 ttggtgccgg tcctgctggg atgacggcag cactttatgc atcacggtcc aatctttctg
    18301 tattgatgat tgaacgcggt gcgcctggtg ggcaaatgaa caacactgct gaggtagaga
    18361 attacccagg ctttgattct attatgggtc cagaattggc ctataaaatg tatgaaaatg
    18421 tagagaaatt tggtacggaa aatgcgtatg gcattgtgat gggcattgaa gaccacggat
    18481 cttataaaga agtgatttgt gatgacaaat cttatgaagc taaagcggta attattgcaa
    18541 caggctgtga acaccgaaaa ttgggtgtaa aaggcgaaga agaatttgct ggccgtggtg
    18601 tttcttattg tgccgtttgt gacggtgctt tctttaaaaa taaacgctta gtagtcgttg
    18661 gcggcggcga ttctgcagtt gaagaagcaa tctatttaac gcaatttgct tctgaagtag
    18721 tgattgttca ccgtcgtgat gaattgcgtg cgcaaaaaat cattcaagat cgtgcctttg
    18781 caaatgaaaa gatttccttt gtttgggata cagttgtcga agaaattgtt ggcaatgaaa
    18841 tggttgtgac aggtgtgaaa gcccggaatg tcaaaacaga tgaagtttct gaaattgaag
    18901 caaacggcgt gttcatttac gtggggctag atccattaac agaaccattt aagaaagctg
    18961 gtattacgaa tgaggctggt tggattgaaa cagaccaaga aatgagaaca aaaattcctg
    19021 gtgtttatgc cattggtgat gtccgtgaaa aaacattgcg tcaaatcact acagcggtcg
    19081 gtgaaggcgg tattgctgga caacaagtat ttaactacat tgaagaatta aaataaaaaa
    19141 atgcttttgc ctttattatt aaaggcaaaa gcatttttta ataggttcct ttaatgccaa
    19201 aataagagcc gcgaatggtt ccagctaatt ttgatttttg acgagcaaat ttgaattttc
    19261 cttcaaattc tgcaggaatt gccataccgt ctgaaagttt aaacccaacg gcgcgtttgc
    19321 cttcatcagc taatgtgtac atcacgttaa ctgctaagcc gttttcataa aatacatagg
    19381 ccatttttat gccatctaaa gtgaaagaag aaatttcaag tggcttgtaa gggaaatgta
    19441 attctcgttc taataaaatt ttttcaatcc aggccaatgt ttctggagct tcagaggcag
    19501 ggacggtcgt aaagcgatgt ttgtatttat tccaaaaata gcgagcttca ttcgctctta
    19561 gtccagcaag aacaggtgcc actggtgaac tttctaaacc aagagtggct acttctttaa
    19621 aatcaactgt ataaaccatg aattgatact cccatctttt cttttaaact aagtataacg
    19681 gtagcagggg taacgaacaa ttattattgc ttaaaagaat gaaattagga cagaacgatc
    19741 ggcttcagaa aatgttaagc tttccgaaag cgtaggttct gtcccgaaga gtattttaag
    19801 atttggttat ttagtgataa gttatacgct tgtacttatt tattggcatc taaagtaact
    19861 ttttcatctg ccgtagtcgt tttaacatct actgtataaa caagtttgtt gttatttttg
    19921 gttaacttcc aagtcaaaat acgtggagaa agtcctccaa cttctttttt tgctttggat
    19981 aagacgtcgt taacagcgcc taattctttg acttcagcag ctgaaaaggc tgtctcgttt
    20041 tcgccaagtt gatttgcttc agtatttttg gtgacttttc ctgtttcagg attcacgtag
    20101 agtgtttctg tatcgttggt aaagatatag ctgtagtcac tttctggttt tgtatcaaat
    20161 tggacattta ctaatggttt gctgttgcca gcttcttttt cgtagatttc agcagcttgc
    20221 tgcaaactaa ctttgtactt agtatctgtg acagcatctt ttcctatgcc acaactagct
    20281 aaaataaaaa tagctcctaa aagtgaaaaa aatagtaaaa atggtttttt taacatgaaa
    20341 ttacctcgtt tccttttatt aagtattcac aatcacttag tatacggagg ttttataaga
    20401 aatacaaata aaaaacaatc ctttaagaga aattaaagga ttgttttttt gttatttatt
    20461 ctgcacgtaa agcaactgcc gcatcttttt tcgctgccat tcgggcagga atatggccac
    20521 caatcatggt taagattgtg ctaattacaa tcaaaataat accgtgaatt ggatttaagg
    20581 tggcaacatt ttctaaatca gtcaggttat agagtactgc gttaatcgga aatgttgcga
    20641 gaaaagcaat cacaacacca agaatgccag aggcaacacc taaaatagca gtttcggcat
    20701 caaacacccg ggtaatatct tttttacgag ctcctaacgc tttcaggata ccgatttctt
    20761 tggttcgctc aatgacagaa gtataggtga tgattccaat cataatcata cttgtaacaa
    20821 gggaaatccc agcaaatgca atcagcacat aggtgatggc atccattaaa ccacctgtta
    20881 agcgggtcat tgttccagct aaatcagaat agatgatttg gtctttttta tcttttcctt
    20941 tgttataagc atctaaataa tcaagaattt tatcttttga tttgaaatcg tttggataaa
    21001 tcataatact tgaaggaatt tcattcgctc ctaaataaga caacaggttt tctttcgcgg
    21061 aagcatctaa tgtttcgtta gtcataacgt tagtattgct ggcttcttgc gctttaacaa
    21121 tgtcagaggt tttg
//
