LOCUS       NZ_CP015163            26500 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis albispora strain WP1 chromosome, complete genome.
ACCESSION   NZ_CP015163
VERSION     NZ_CP015163.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis albispora
  ORGANISM  Amycolatopsis albispora
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Complete genome sequence and analysis of deep-sea sediment isolate,
            Amycolatopsis sp. WP1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2016) Zhejiang University of Technology, College
            of Pharmaceutical Science, Chaowang Road No.18, Hangzhou 310014,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera assembler v. unspecified
            Genome Coverage                   :: 138.17X
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:57:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,537
            CDSs (total)                      :: 8,472
            Genes (coding)                    :: 8,394
            CDSs (with protein)               :: 8,394
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 26 of 78
            Pseudo Genes (incomplete)         :: 54 of 78
            Pseudo Genes (internal stop)      :: 6 of 78
            Pseudo Genes (multiple problems)  :: 7 of 78
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:20:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5292388
            Orig. end                         :: 5318888
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015163.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26500
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="23"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26500
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26500
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16500](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16500)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    305..318
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     gene            complement(1042..1821)
                     /gene="fetB"
                     /locus_tag="A4R43_RS24890"
                     /old_locus_tag="A4R43_24625"
     CDS             complement(1042..1821)
                     /codon_start=1
                     /gene="fetB"
                     /inference="COORDINATES: protein motif:HMM:TIGR00245.1"
                     /locus_tag="A4R43_RS24890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24625"
                     /product="iron export ABC transporter permease subunit
                     FetB"
                     /protein_id="WP_112276288.1"
                     /transl_table=11
                     /translation="MTGLSVPSWGGVAASLLLIALTAAVAYRQRLHLTRELITASLRAG
                     AQLAAVGVLLLVIFAHTGLPGAFGWVTIMILLAGQVAGRRGTGLPRARWAATLGVAVGS
                     LVTLATLLGLGIISTQARVVVPIGGMIVSGAMQAAGVALRRLREDAQQARPAIEARLCL
                     GLPARDAFLPHQRSALRTALLPAIDSTKVVGLISLPGAMTGLILAGVDPLTAIRYQIVV
                     MYMLLAATALAALTAARLVEHALFDHAHRLIPLPEPH"
     gene            complement(1821..2498)
                     /locus_tag="A4R43_RS24895"
                     /old_locus_tag="A4R43_24630"
     CDS             complement(1821..2498)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="A4R43_RS24895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24630"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_075849301.1"
                     /transl_table=11
                     /translation="MSTVPGFLLDRVTVTRGPTRLLDGVCARLPAGACTAVVGPSGAGK
                     STLLRLLNRLEDPSTGQILLNSTPLAELEVLALRRRVGLVAQQPVLLTNHVAEELRVGR
                     AELTEHRIQHLLDLVGLPARFAQRRTSGLSGGEAQRVCLARTLAVEPEVLLLDEPTAAL
                     DAVTTAVITEAARNHTAAGGTVILVSHDLPLVRGIAEHVLVLHHGRLVAHGHPDHIDYL
                     EAG"
     gene            complement(2495..3892)
                     /locus_tag="A4R43_RS24900"
                     /old_locus_tag="A4R43_24635"
     CDS             complement(2495..3892)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="A4R43_RS24900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24635"
                     /product="ATP-binding protein"
                     /protein_id="WP_113694547.1"
                     /transl_table=11
                     /translation="MIRRWPLRIRLTAAFTVMMALVLLGVGIVTVTHTRESLDASISES
                     LEHRLRDLQPIATTAAPVLSSGGRDTGEQVLDDAGQIIASSPDVADQPLLTPAELATAR
                     RGELVVDHATAGQLDGPVRIAAAPTGADGRIAVAAVTLADRDAAVADLRQELAVGLPLA
                     LLAAAVGAYLLAAAALRPVERMRARAATITAAHPTQRLPVPSARDEISRLGTTFNDLLD
                     RLHAAVERERQFVADASHELRTPLSLLTTELELAARRPRTTRELTAALGSALEETERLS
                     RLAQDLLLLARTDQAGPPARPGEPTPVRPVLESVIARYRSTLDEHQVILDCTPELTVRA
                     DPGDLDRAVSNLIDNAARHGQPPIIITASPPDTELGVSIRVRDHGSGIAPEFLPHAFDR
                     FTRADDARTGGGTGLGLALVAALARRNGGAATAANHPDGGTTVILTLPAANHPDATIPD
                     APAAAPG"
     gene            complement(3889..4587)
                     /locus_tag="A4R43_RS24905"
                     /old_locus_tag="A4R43_24640"
     CDS             complement(3889..4587)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673047.1"
                     /locus_tag="A4R43_RS24905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24640"
                     /product="response regulator transcription factor"
                     /protein_id="WP_205215529.1"
                     /transl_table=11
                     /translation="MRVLVVEDEPKMAGLLRRGLVEEGYAVDVATDGADGFGAAVSRDY
                     DAVVLDVMLPRLSGFEMCRRLRRQQVWVPVLMLTARDAVTDRISGLDGGADDYLTKPFH
                     LEELFARLRALTRRGPVARPTVLTAGDLRIDPASRRCWRGETEIAVTAKEYALLEMFLR
                     QPGVVLTRELLLEHCWDFAYESRSNVVEVHIRALRDKIDRPFAVVSLETVRGAGYRLRP
                     DGGRPRVGAR"
     misc_feature    4714..4727
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            4776..5108
                     /locus_tag="A4R43_RS24910"
                     /old_locus_tag="A4R43_24645"
     CDS             4776..5108
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS24910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_24645"
                     /product="PepSY domain-containing protein"
                     /protein_id="WP_075849307.1"
                     /transl_table=11
                     /translation="MNRKTKIGIGIAAGVLVLTGGGVGLASAMSGDGDEVSGPAADQAR
                     AAAVQSVPGGKAGAVETETDEGAAAYGVTVTKPDGSTVEVHLDSTFHVVGTEAPGQDHD
                     ADGDEG"
     gene            5168..6142
                     /locus_tag="A4R43_RS24915"
                     /old_locus_tag="A4R43_24650"
     CDS             5168..6142
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030378.1"
                     /locus_tag="A4R43_RS24915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24650"
                     /product="DUF1259 domain-containing protein"
                     /protein_id="WP_083666521.1"
                     /transl_table=11
                     /translation="MPFTPARAARVVLPLAALLLVPLAGCGTDTTPASDTAADAEHRRH
                     QPIPTTEADWKPVTDTLGRTGKFGDNNTVYRIGLPRTDLQVTSGGVEIKPGLSLGGYAA
                     FAKYRDGVMLMGDLVVTEAELPKVTDALQAHGIAQTALHKHLLQQTPPVWWTHIHAMSD
                     DPAALAQGVQAALDATAIPAPAPPGQQPPIDLDTAGIDQALGRKGTADGGIYKFSIARK
                     ETITDDGHVLPPTFGVTTAINFQPLGGGRAAINGDFVMTAPEVQKVIQALRTGGIDLVE
                     VHNHSLTEQPRLFYMHFWAVDDGVTLAKALRPALDATNLQPPG"
     gene            6241..6453
                     /locus_tag="A4R43_RS24920"
                     /old_locus_tag="A4R43_24655"
     CDS             6241..6453
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015996.4"
                     /locus_tag="A4R43_RS24920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24655"
                     /product="DUF378 domain-containing protein"
                     /protein_id="WP_091679556.1"
                     /transl_table=11
                     /translation="MRPRTVLDWIAFVLLLIGAFAWAAFVTDINVLDRALEPIADPLDD
                     IVFVLIGLAGLYWIGRVVVGDRTHQ"
     gene            6537..6995
                     /locus_tag="A4R43_RS24925"
                     /old_locus_tag="A4R43_24660"
     CDS             6537..6995
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030379.1"
                     /locus_tag="A4R43_RS24925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24660"
                     /product="Chromate resistance protein ChrB"
                     /protein_id="WP_091679585.1"
                     /transl_table=11
                     /translation="MLLSYRMPREPSTPRITVWRKLKRLGVAQLGDGLVALPADARTRE
                     HLDWIADEILAAGGTAGVWLAQPTSLAQERRLAQTMAAARAAEYRAVLTEAEQARSLGE
                     AERRRALRTLRAELRRIHRRDYFPPPERDTAQAAVDALHPDHHTEETA"
     gene            6992..7423
                     /locus_tag="A4R43_RS24930"
                     /old_locus_tag="A4R43_24665"
     CDS             6992..7423
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030380.1"
                     /locus_tag="A4R43_RS24930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24665"
                     /product="chromate resistance protein ChrB
                     domain-containing protein"
                     /protein_id="WP_112276286.1"
                     /transl_table=11
                     /translation="MKWATREHIHIDRAACAWLIRRCIDPDAAFVFVTDPADVPPDATP
                     FDMRGVDLGHHGDDCSFETILRRHDLTDPVLWRIAEIIHEADLDDERYDAPEAPGLDAI
                     LRGLSMIGDDQHTLTITKPIFDGLYEYYHRAQMLGREPA"
     gene            7420..8025
                     /locus_tag="A4R43_RS24935"
                     /old_locus_tag="A4R43_24670"
     CDS             7420..8025
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016149.4"
                     /locus_tag="A4R43_RS24935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24670"
                     /product="copper resistance CopC family protein"
                     /protein_id="WP_075849313.1"
                     /transl_table=11
                     /translation="MTAGNIRRATLGILAALLCASLLGTDHPATATPSSAVPLLEEATP
                     PANAVLTEPVDWVYLTFDRLINTFSIRVTGPNGHDVARDNAIVKHDMISQPLHTLTQPG
                     TYRVTWQVIDLDGHQASGSHSFTITPGVTTTPENTATTPATTPHSVPPTAPPATNQSTI
                     TTPLAATIALSLLAGLTLLTIRHRRRVRASRAQRPDRT"
     gene            complement(8160..8711)
                     /locus_tag="A4R43_RS24940"
                     /old_locus_tag="A4R43_24675"
     CDS             complement(8160..8711)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013315.4"
                     /locus_tag="A4R43_RS24940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24675"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_205215079.1"
                     /sec_met_domain="PCMT (E-value: 3.9e-37, bitscore: 127.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVERIQKAGHAKHSDVERVLRDTPRHEFVPDADLAVAYDPWQAVV
                     THRFEDGRSLSCASAPWLVAAMLDQLDVQPGNRILEIGVGTGYNASLLAQLTGRADLVT
                     TIDVDPDVTAKASQALAAAGYGDVHVITGDGGLGYPDHAPYDRMIATVSPWDIPAQWWK
                     QLAPGERLVAPLRFPVKSAC"
     gene            complement(8871..9914)
                     /locus_tag="A4R43_RS24945"
                     /old_locus_tag="A4R43_24680"
     CDS             complement(8871..9914)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151818.1"
                     /locus_tag="A4R43_RS24945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24680"
                     /product="hypothetical protein"
                     /protein_id="WP_236808250.1"
                     /transl_table=11
                     /translation="MAELCDRARQVEHSGDLAEAAAVHNNAALIASDCGLPELARRWCH
                     QQVNIYLRARPLGAQVARLALEPITNLARLYIREGQGERAFALMDTLFTAVSARTDAIV
                     DGIEIPADLTDSAETHQHIRSWLWAVLLATGGRALAAAGRWAEARARLDAYKGVGRRML
                     DGRQIAVIAHAVSGDADSALALLAETTPGDPWENAVTACLTIQCHGASGVADLPTLLNQ
                     YHRLDTSAPGLAVFHTRLGLSFIDAIGTVDDPPVHQIAVDLIDYAAATRDGYVARDVLA
                     HNGCRELLTDSQARELSDSVEACALGSGTLPATLLADLTTALACAEEAMARSVKTMSCN
                     VNAPANP"
     gene            complement(10001..12094)
                     /gene="fxlM"
                     /locus_tag="A4R43_RS24950"
                     /old_locus_tag="A4R43_24685"
     CDS             complement(10001..12094)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="A4R43_RS24950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24685"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_113694548.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.2e-32, bitscore:
                     111.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.1e-44, bitscore: 151.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPDSWHHYLVEFADPTTAEHTAATLLVPALDQAQQDGELDTWWH
                     LRKTPAWRLRYQSVNPETKAVDTLLSDLQADGHLARWTRGIYEPETLAFGGPAAMDIAH
                     SLFHHDSRHCLARATKPAALGQRETTVLLFSSMLRAAGLDWFEQGDVWGKVAALRPTAQ
                     PHTNNSPHTERLSQAVRRLMTTNTHKVADVAPDVVPETWWTAFDTAGRQLAELARAGHL
                     ERGLRAVLAHHFIFHANRAGLSGTDQATLAALAVDTVFHSTPTRQAPAGTTSNTVRVPA
                     MTTTVSDASTGSADELRTKLADRLVKDGTVRTDAVEAAFRQVPRHLFLPDVPLVEAYAD
                     EPVYTKHEGDGTRISAASQPKIVAMMLEQLGIQPGERLLELGAATGYNAALMATLTGAD
                     GHVTTIDIDEDLVDGAREHLSAANIDNVEAVAADGALGHPETAPFDRVIATVGAHEVPA
                     AWLDQLTPGGRLVAPVRLRGCASRSIVFERDQDGWRSLDSEMAIFMPLRGLGDDARRVL
                     DLTGTGEVTLQIHKDNNHATDPDTLAGVFDSPACEVWTGVHFVPMESFEWLDLWLACHL
                     PNPLMRMEVAPAAKESGLVRPMFPSVAMATTAADGSLAYLTIRAADPDPDGRRRYEVGV
                     IGHGPNAQELAEQVSVEISTWDQSFRSSTVRFAIPDTAPQPDTNPGFVVLDRATKPMTV
                     TWE"
     gene            complement(12140..13390)
                     /locus_tag="A4R43_RS24955"
                     /old_locus_tag="A4R43_24690"
     CDS             complement(12140..13390)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151816.1"
                     /locus_tag="A4R43_RS24955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24690"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_113694549.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-43, bitscore:
                     148.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNADLASDAAVEYATGIADRLARPDAPHLPTDEPWWHQSLAHGAP
                     GVALLHIELAAAGIRPFDRAHDWLTAVTSKPITAGASTGLFYGAPAVARALAGAATVRP
                     GTYQSALTPLTRQIAADAHNRVDKAHERMDVVGMLPQMAEFDTIRGLAGLGAHLLHHDP
                     DGTALPAVLGALVRLTQPVMVEGEALPGWWTLTGPTGHADEEFPGGHGNFGVAHGIGGP
                     LALLAQALRRGIAVDGQRQAVATICAWLDSWRISTPSGHRWPYMVTRDEARSTPMYVRH
                     SGASRRPSWCYGTAGIARTLHLAALALDDADRRQIAEEAVISAVTDPEQDALISDASLC
                     HGYAGLARITAHTAIDTPEPAASRLRALATEMLHRACAQAVPEGPGFLEGAAGIGLAAL
                     AAEIEPATGWGTGLLIT"
     gene            complement(13387..16500)
                     /locus_tag="A4R43_RS24960"
                     /old_locus_tag="A4R43_24695"
     CDS             complement(13387..16500)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151815.1"
                     /locus_tag="A4R43_RS24960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24695"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_186361385.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.2e-201,
                     bitscore: 667.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1e-17,
                     bitscore: 63.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.3e-19, bitscore:
                     68.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTALPDRVGFRAAGGLLVRAVAEGELKLPPWPTLTATGADAVTA
                     WVDWLREVWEVEAVRDAIGLASPVLADRVHNLCGAQVASERESRRVVLSVLRYLARLTG
                     RPTPNGLFAGVTAARFDADPSQRWGDDHRADAAADAGWLAEVIRRLEGQAEILERLVLV
                     ANSTLMVRGERLVVPYQPTVNHRGTGAVEVELRYTGPVRAAVRAARTPIPFDDMREQVQ
                     AEFPSTAGSTVTGLLATLVARRVLVTNLHAPSTEPDALGHLVRELATVGEAATERCMTL
                     NDIHDMLRRHRNSPAEARRRLRTDAAASMSRLAPSRRSPVTVDLRLDLDVVLPSAVARE
                     AERAALVLARLTSRASGTAAWADFHRRFYQRFGTGAQVPLLEVIADSGIGWPDGYPGTS
                     GVVTRPQQTPRDERLLALAQAAALDGQQEVVLGERLIAELELAPVHSMRLPSHLELCAR
                     VDSPSLQALKQGNFQLVVTSVSRSAGVVSGRFLHLFDEHDRRMLITPLAPPASDGVIQA
                     QLSFPPLDPATAHVARSAQVLPTIVSLAEHRDTAASTAVLTAADLAVSCDSDRLYLTAP
                     ALGARVEAWGLHALNLRKHTPPLARLLVELTRAHCAEVTDFDWGTAATLPFLPRLRFGR
                     IVLSPARWRLAAADLPDRTSSWATWDSALAEWRTRRRLPQAVFLVDGDWRLPLDLVEDA
                     HRVLLREHLGTHPHAVLEEGPAEDAAGWLDGRAHDVVVPMASCQPQATTRPPRPTPQRI
                     VRPGEHGLSPGGSPMLFAKLYGDPQRHNTVLAKHLPALLAEWGDAQPRWWFLRFREGNE
                     HYLRLRISLLSTEPVVFGEAAGRVSAWADRLRRLGLLRDIAFATSYPETGRWGSGAALS
                     AVEAFFTADSRAVLAELAWPARPHDHALAAANFAAIAVAFMGGTEAGMRWLVDHVPAKP
                     PTVVPRPVFTEAQCLADPSENFRALRSTPGAASVVATWAERAQTVAAYRAHLSGAEAEG
                     VDPDAALGSLLHTHFLRAYGIEPDDKAVCLYLARTAALTFAARTGGPR"
     aSDomain        complement(15742..16017)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R43_RS24960_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.30E-20"
                     /identifier="RREFam001.1"
                     /label="A4R43_RS24960"
                     /locus_tag="A4R43_RS24960"
                     /protein_end="253"
                     /protein_start="161"
                     /score="63.6"
                     /tool="antismash"
                     /translation="LVANSTLMVRGERLVVPYQPTVNHRGTGAVEVELRYTGPVRAAVR
                     AARTPIPFDDMREQVQAEFPSTAGSTVTGLLATLVARRVLVTNLHAP"
     gene            complement(16582..16767)
                     /locus_tag="A4R43_RS24965"
     CDS             complement(16582..16767)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151814.1"
                     /locus_tag="A4R43_RS24965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_009151814.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.2e-15, bitscore:
                     54.0, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQMEWSPTTVATPAAEVEMGSEFDLDITLVEVVDPAHLINMTD
                     DGCGTTCEKSTCISAA"
     CDS_motif       complement(16654..16767)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTVQMEWSPTTVATPAAEVEMGSEFDLDITLVEVVDPA"
                     /locus_tag="A4R43_RS24965_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16582..16653)
                     /prepeptide="core"
                     /locus_tag="A4R43_RS24965_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="1.70"
                     /molecular_weight="2263.5"
                     /monoisotopic_mass="2262.0"
                     /core_sequence="HLINMTDDGCGTTCEKSTCISAA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTVQMEWSPTTVATPAAEVEMGSEFDLDITLVEVVDPA"
                     /leader_location="[16653:16767](-)"
                     /alternative_weights="2281.5"
                     /alternative_weights="2299.6"
                     /alternative_weights="2317.6"
     gene            17218..18501
                     /locus_tag="A4R43_RS24970"
                     /old_locus_tag="A4R43_24700"
     CDS             17218..18501
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009151813.1"
                     /locus_tag="A4R43_RS24970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24700"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_112276300.1"
                     /transl_table=11
                     /translation="MSDRRDAFAARREQMGYTQESFGAAVGVEFSTVGRWERGTLTPQP
                     YRRPCLAKTLDVSLDQLDALLTPNRQASTVATEPADPAEADDMNRRDLLRLFSMTGALL
                     ALPAGETVLGDVDRLAATAHAGTVDTAGAAEFAQLNSHLWRVYALSPTKAQVLPLVRAQ
                     LGVLSDSLRRPQTPTIRQRLCELTADLFQLAGEIFFDGNRYTDAAHCYTLAATASKEAV
                     ASDLWACALTRHAFVAVYERRFADAAPMLDVAATIARRGDPSLSTRHWVAVVQAETFAG
                     LGDFDSCQHALDTAAEVQRLRGQVHNGGWLRFDGSRLAEERGTCYVTLGRHDLAEAALV
                     DALQGTLTARRKAGVLTDLAMIGVHRRDPDQVVTYADTVLTTARQTRSGVIAQKLRVLQ
                     PHLASLLNDQQIQRLDAEITKLVGNRAA"
     gene            18501..18875
                     /locus_tag="A4R43_RS24975"
                     /old_locus_tag="A4R43_24705"
     CDS             18501..18875
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020501062.1"
                     /locus_tag="A4R43_RS24975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24705"
                     /product="hypothetical protein"
                     /protein_id="WP_233520190.1"
                     /transl_table=11
                     /translation="MEDDRMHNDRGRVFREAWIAGVTKHYPGEPKPGYITPWDQTPDWE
                     RDAATAVYDQVVAFIKATDGATTKLTPDQKGRFVALCWIGQIFKHFPEPKPSYVADWND
                     LPDWQKATDIDIFERIERDA"
     gene            18868..19383
                     /locus_tag="A4R43_RS24980"
                     /old_locus_tag="A4R43_24710"
     CDS             18868..19383
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020501063.1"
                     /locus_tag="A4R43_RS24980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24710"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_113694550.1"
                     /transl_table=11
                     /translation="MPDQATIDAAAVDARLAETEYDDAQAWLHARSTALEPLAAEVWVT
                     DPEHRHVLLVRHRVRGWVPPGGTVEPGETPRAAAARELLEETGLLGELLSVPAAVAVRS
                     FRADWTPTLSLSYGAVINRDAPLGGEKGQPPKWVDLDESWESVFPEDRDRIRAYVRRLA
                     AEHAVEAR"
     gene            complement(19898..20305)
                     /locus_tag="A4R43_RS42885"
                     /old_locus_tag="A4R43_24715"
     CDS             complement(19898..20305)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037950.1"
                     /locus_tag="A4R43_RS42885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24715"
                     /product="bacteriophage spanin2 family protein"
                     /protein_id="WP_005456771.1"
                     /transl_table=11
                     /translation="MRISTRWTSVLLGVGVVAAISGCGAVQQAGDTAGSAADTVTGAVA
                     AAEVCSDALALVANPPDLSAPQAALDQAHTTATELTDLAATTSDTDIGRAITDLAATLQ
                     TATLDTLTSAPAAWLQTRADQAAALTTACAP"
     gene            complement(20406..21455)
                     /locus_tag="A4R43_RS24990"
                     /old_locus_tag="A4R43_24720"
     CDS             complement(20406..21455)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646712.1"
                     /locus_tag="A4R43_RS24990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24720"
                     /product="TerC family protein"
                     /protein_id="WP_005456772.1"
                     /transl_table=11
                     /translation="MVVPLWAWAAVLGVILVMLAIDLFAHRRAHVVGVREAAAWSAVWV
                     ALGLGFGAIVWWAWGSEFAAQYFAGYVIEKSLAVDNVFVFAIIFGYFAVPREYQHRVLF
                     YGVLGALVFRAVFIAAGSVLIASFAWILYVFGAFLVATGVRMAVHRNETIDPDRSVVLR
                     LFRKVIPTTEEYHGQKFLVRQAGRWVATPLLAVLVLVEVTDIVFAVDSIPAIFAITQQP
                     FLVFTSNAFAILGLRAMYFLLADLMHRFIYLKLGLALVLVWVGIKMLLLDLYKIPTWFS
                     LAVVALLLAVAVTASWIRTRTTPATPAAASADSLAGAEPDTVTTEPAQTGAAAAETAPS
                     SPTGLSTRD"
     misc_feature    21658..21672
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.61"
                     /tool="antismash"
     gene            21725..22222
                     /locus_tag="A4R43_RS24995"
                     /old_locus_tag="A4R43_24725"
     CDS             21725..22222
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS24995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_24725"
                     /product="hypothetical protein"
                     /protein_id="WP_005456773.1"
                     /transl_table=11
                     /translation="MPAQCTTLVCVVDATDPAPAAELPAAVELIADHGHLVLAVLHPPP
                     GLTLNARLIAWQQVRREQVTAAALAPALSRLPSSGLAERGVRIHTTAWHHRRGPGGRHR
                     RVAAALLRLCRVHDADVLVLPAHPRAELLTPATCQYLLGLTQPRLRIRRADEHTLPDAM
                     LV"
     gene            22311..22790
                     /locus_tag="A4R43_RS25000"
                     /old_locus_tag="A4R43_24730"
     CDS             22311..22790
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS25000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_24730"
                     /product="winged helix-turn-helix transcriptional
                     regulator"
                     /protein_id="WP_177242873.1"
                     /transl_table=11
                     /translation="MRPAEPPPDHALPTPAGSDPTDSGTVDSGVVDAGAEPADAAASQT
                     PGSWMFLSNHAHVLLCLAADPHQTLPVIAQKVGITTRAVQLILTDLIQGGYIERTKVGR
                     RNHYRINPDGHLRHPLEAHHRIADLITAVGPATPDDARDASADGASTPPRRRRTG"
     gene            complement(23200..24204)
                     /locus_tag="A4R43_RS25005"
                     /old_locus_tag="A4R43_24735"
     CDS             complement(23200..24204)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005456776.1"
                     /locus_tag="A4R43_RS25005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24735"
                     /product="TerC/Alx family metal homeostasis membrane
                     protein"
                     /protein_id="WP_177242874.1"
                     /transl_table=11
                     /translation="MAAPADSVGSSSIGSPWLWVASIAVILGLLVTDFAVTRRPHEVSI
                     REAIGWSVFYLTLPVLFGIWLWAVFDSGPALEFITGFVVEKSLSVDNLFVFMLILAGFA
                     VPSPIQQRVLLYGIAGALVLRGIFIAAGAALLQAGTWAFLLFGLILLVSAGKILHEVHT
                     GSAFAGRDVSQMRIVRLLRRFMPVTDDYRGTRLTVREHGRRALTPLAVVVAAVFVTDVV
                     FAVDSVPAVYGITADPYLVFATNAFALLGLRALYFVLHATLAKLVYLNHGLAVILAFIG
                     LKLVLHWAHGIWPATPQIPTPVSLAVIVAILAVVIAASLRTRRRAEQHVIEKD"
     gene            24425..25741
                     /locus_tag="A4R43_RS25010"
                     /old_locus_tag="A4R43_24740"
     CDS             24425..25741
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /GO_function="GO:0016881 - acid-amino acid ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01499.1"
                     /locus_tag="A4R43_RS25010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_24740"
                     /product="cyanophycin synthetase"
                     /protein_id="WP_005456777.1"
                     /transl_table=11
                     /translation="MRRAGVWQWLDGHVDHERGVGVAAGGVVSQAPTTVVIERLLRTLG
                     RPEQRVPVILVAGTNGKSTTARILAAVLAGSGLRVGLYTSPHLHRPQERITIDGVTITD
                     DELAAVLDPLVADERTASELGRPSWFELMTAAAVGWFADQRVDVAVVETGLGGSGDATA
                     ALGAGLVVVTSVGVDHVEYFGDTRWDNAVAEAGAVPEGATVVLAEADPAMHPPFLGRRP
                     SRVVTVDRDFGVAADAPVADGRTVSLFTPGATYDDVFLRLLAPWQAANAATALAAAEVW
                     LARPVADQVVRAVCGALRASGRFELVHTPGPVLMDGAHNEEAATALARALRERFDGVSR
                     TVVVGMTGTRAPEAFLSALGVGAGDWVICTSPRTPRAVPLARLAAAARAVGAGSVAVEA
                     DVGDAVRRAAAANDSTLTVVTGSLYVIGEALPVVRALVT"
ORIGIN
        1 gaactgcacg accatgatca gcgggccggg ggtggactcg gccagagcga ggccccgcac
       61 catgtcttgg gcggagagcc agccgtagac ctcgacggcg cgctgggcga cgaaggcgag
      121 cacggcgtag gcgccgccga aggtgaccac ggcggtgccg gagaagaaca gcccctgcgt
      181 ggtgagcgtg ctgcccacgc cggtgaacac cgccaccgcg gcgatcgggg cggcccagag
      241 cagcagaccg acaccgagca cggtcaggct ccgccgtgta gagggggctt cgtggtgcag
      301 ggcgtcgtcg gggatcaacg gtgctggtcc gtcggcggcg ccgttggtgg gcgggggttt
      361 gatcgtgcgg ggtgcgaacc ggccgagtgc ccagccgatg gccgctgctg cggcgatgac
      421 gatcgggaac gggaccgcga acaccgccag cgccacaaag ccggcggcgg cgatcccgat
      481 gagcgcgggg tggtgcagga cgcgtttgcc gaccctgggt acggcttggg cgatgatcgc
      541 gaccaccgcg ggtgcgagcc cggcgaagat cgcggtcacc agggtggtgt cgccgaacgt
      601 cacgtagatg gccgacagcg cgagcagggc aaccatgccg ggcagcacga acagggtccc
      661 ggcgatgatc ccgccgcggc ggccgttgag tagccatccc acgtagatgg ccagctgctg
      721 ggcttcgggg ccgggcagca gcatgcagta gttcagcgcg tgcaggaagc gttgttggcc
      781 gatccagcgt ttctcctcga ccagggtgcg ttgcatgacc gcgatctgcc cggccgggcc
      841 tccgaacgtc tgcagcgaga tcagaaacca cgcccaggtc gcggtacgca gtgggatgac
      901 gtcccggttc gcggtttcgg acatgggtga gcgtccctcc tcgttcaact ccacgcgcaa
      961 tgtaaccatg gttgcactag tgcggtggag gggtgtccag gtggcgggat gcgggctggc
     1021 cgaggcggtg ggagtggtcg gttagtgggg ttcggggagt gggatgaggc ggtgggcgtg
     1081 gtcgaacagg gcgtgttcga cgagccgggc tgcggtgaga gcggcgagtg cggtggcggc
     1141 gagcagcatg tacatgacca cgatctggta gcggatggcg gtgagggggt cgacgccggc
     1201 gaggatgagt ccggtcatgg ctccgggcag gctgatcagg ccgacgacct tggtggagtc
     1261 gatcgcgggc agcagcgcgg tgcgcagcgc ggagcgttgg tggggcagga acgcgtcgcg
     1321 ggcggggagc ccgaggcaga gccgggcttc gatggctggg cgggcctgct gggcgtcttc
     1381 gcgcaggcgg cgcagggcga ccccggcggc ctgcatggct ccggagacga tcatgccgcc
     1441 gatcgggacg acgacccgcg cttgggtgga gatgatcccg aggcccagca gcgtggcgag
     1501 ggtgacgagg ctgccgacgg cgaccccgag ggtggctgcc caccgggctc ggggcaggcc
     1561 ggtgccgcgg cggccggcga cctgtccggc gaggaggatc atgatcgtca cccagccgaa
     1621 cgcgccggga aggccggtgt gggcgaagat caccagcagc aggacgccga ccgcggccag
     1681 ctgtgccccg gcgcgcagcg atgcggtgat cagctcgcgg gtcaggtgca gccgctgccg
     1741 gtaggccacc gcggcggtga gggcgatcaa cagcagggag gcggcgacgc cgccccagct
     1801 gggcacggac agtccggtca tcacccggcc tccaggtagt cgatgtggtc ggggtgcccg
     1861 tgggcgacca ggcgcccgtg gtgcaggacc agcacgtgct cggcgatgcc gcgaacgagg
     1921 gggaggtcgt ggctgaccag gatcacggtc ccgcccgcgg cggtgtggtt gcgggcggcc
     1981 tcggtgatca ccgctgtggt cacggcgtcc agcgcggcgg tgggctcgtc cagcagcagg
     2041 acctcgggtt cgacggccag cgtccgggcc aggcacaccc gctgcgcttc gccgccggac
     2101 aggccgctgg tgcggcgttg cgcgaagcgt gcgggcaggc ccacgagatc gagcaggtgc
     2161 tggatgcggt gctcggtcag ctccgcgcgt ccgacacgca gctcctcggc cacgtggttg
     2221 gtgagcagca ccggctgttg cgcgaccagg ccgacccggc gccgcagtgc cagcacttcg
     2281 agctcggcga gcggggtgct gttgagcagg atctggccgg tactggggtc ctccagccgg
     2341 ttgagcaggc gcagcagggt ggacttgccg gcgccgctgg gaccgaccac cgccgtgcac
     2401 gctccggccg ggagacgggc gcagactccg tcgagcagtc gggttgggcc gcgggtcacc
     2461 gtgacccggt ccagaagaaa accgggcacg gtgctcatcc gggtgcggcg gccggggcgt
     2521 ccggaatggt ggcgtcggga tggttggcgg cggggagggt gaggatgacg gtggtgccgc
     2581 cgtcgggatg gttggcggca gtcgcggcac cgccgttgcg gcgggccagc gcggcgacca
     2641 gggccaggcc cagtccggtg ccgccgccgg tgcgggcgtc gtcggcgcgg gtgaagcggt
     2701 cgaacgcgtg cggcaggaac tcgggggcga tgccggagcc gtggtcacgc acccggatgc
     2761 tcaccccaag ctcggtgtcg ggcgggctgg ccgtgatgat gatgggtggc tgcccgtgcc
     2821 gggcggcgtt gtcgatcagg ttgctcaccg cccggtcgag atcgccggga tcggcgcgca
     2881 ccgtgagctc cggtgtgcag tccaggatca cttggtgctc gtcgagggtg ctgcggtagc
     2941 gggcgatcac tgactccagc acgggacgca ccggggtggg ctcgccgggc cgggccggcg
     3001 gaccggcctg gtcggtgcgg gcgagcagga ggaggtcctg ggccaggcgg gatagtcgtt
     3061 cggtttcctc caatgccgag cccagcgcgg cggtcagttc ccgtgtggtg cggggtcggc
     3121 gcgccgcgag ttcgagttcg gtggtcagca ggctgagcgg ggtgcggagc tcgtggctgg
     3181 cgtcggcgac gaactgccgt tcccgctcga cagcggcgtg caggcggtcg agtagatcgt
     3241 tgaacgtggt gcccagccgg gagatttcgt cgcgagccga cggcacgggt agacgctgcg
     3301 tggggtgtgc ggcggtgatg gtggcggcgc gggcgcgcat ccgttccacc ggtcgcagtg
     3361 cggcggcggc cagcaggtag gccccgaccg cggcggcgag cagcgccagc ggcaggccga
     3421 ccgccagttc ttggcgtagg tcggccaccg cggcgtcgcg gtcggcgagg gtcaccgcgg
     3481 ccacggcgat ccggccgtcc gcaccggtgg gggcggcggc gatacgcacc ggcccgtcca
     3541 gctgtccggc ggtggcgtga tcgaccacga gctcgccgcg ccgcgcggtc gccagctccg
     3601 ctggagtcag caggggctgg tcggccacgt ccggggagct ggcgatgatc tggcctgcgt
     3661 cgtcgaggac ctgctcgccg gtgtcccggc cgccgctgga cagcactggt gcggcggtgg
     3721 tggcgatcgg ttggaggtcg cgcagccggt gctccaacga ttcgctgatc gaggcgtcga
     3781 gcgattcgcg tgtgtgcgtc acggtgacga tcccgactcc gagcaggacc agcgccatca
     3841 tcaccgtgaa cgcggcggtg agccggatcc ggagcggcca ccgccggatc atcgcgcccc
     3901 cacccgcggc cgtccaccat ccggccggag ccggtacccg gcgccgcgca cggtctccag
     3961 cgagaccacc gcgaatggcc ggtcgatctt gtcccgcagc gcgcggatgt gcacctcgac
     4021 gacgttggag cgggattcgt aggcgaagtc ccagcagtgc tccagcagca gctcgcgggt
     4081 gagcaccacg ccgggctggc gcaggaacat ctccagcagc gcgtactcct tggccgtcac
     4141 cgcgatctcg gtctcgccgc gccagcaccg ccggctggcc gggtcgatcc gcagatcgcc
     4201 cgcggtgagc acggtggggc gggcgaccgg gccgcggcgg gtcaatgccc gcaaccgagc
     4261 gaacagctcc tccaggtgga acggcttggt cagatagtcg tccgcgccgc cgtccaggcc
     4321 gctgatccga tcggtcaccg cgtcacgggc ggtgagcatc agcaccggca cccacacctg
     4381 ctggcggcgc agtcgccggc acatctcgaa ccccgacagc cggggcagca tcacgtccag
     4441 caccaccgcg tcgtagtcgc ggctgaccgc cgccccgaac ccgtcggccc cgtctgtggc
     4501 gacatcgacg gcgtagccct cctcgaccag gccacggcgc agcaggcccg ccatcttcgg
     4561 ctcatcctcc accaccagta cccgcaccat ccatcacctc tcttcaggcg ccacccccga
     4621 gcaccctgca caggcgcccc ttcacgggca cggtgccacc acatccgggt gaccgccgtc
     4681 gtgtcttcat cacggcttca tctccaccga ctacccatac ccatgcaacc acctcatgca
     4741 accacggtta caggagcgtg gagaatggag aaggcatgaa ccgcaagacg aagatcggga
     4801 tcgggatcgc cgccggagtg ctcgtcctca ctggtggggg cgtgggcctg gcctccgcga
     4861 tgtccggcga cggcgacgag gtcagcggcc ccgcggccga ccaggcacga gccgcggccg
     4921 tgcagtccgt gcccggcggg aaggccggcg ctgtcgagac cgagaccgac gagggcgccg
     4981 ccgcctacgg cgtcaccgtc accaagcccg acggctccac cgtcgaggtc cacctcgaca
     5041 gcaccttcca cgtcgtgggc accgaggctc ccggccagga ccacgacgcc gacggtgacg
     5101 agggctgacc gcgtaccacc gaccacgatc tacaccgacc acgatcgagt tcgaggaggg
     5161 caaggacatg ccgttcaccc ccgcccgcgc ggcccgcgtg gtgttgccgc tggccgcgct
     5221 gctgctggtc ccgctcgccg gctgtggcac cgacaccacc cccgccagcg acaccgctgc
     5281 cgacgccgag catcggcgcc accagccgat ccccaccacc gaggcggact ggaagccggt
     5341 caccgacacc ctgggccgca ccgggaagtt cggcgacaac aacaccgtct accgcatcgg
     5401 cctgccccgc accgacctgc aggtcacctc cggcggcgtc gagatcaaac cagggctgtc
     5461 gctgggcggc tacgccgcct tcgcgaagta ccgcgacggc gtcatgctca tgggcgacct
     5521 ggtggtcacc gaggccgaac tgcccaaggt caccgacgca ctccaagccc acggcatcgc
     5581 gcagaccgcg ctgcacaaac acctgctgca gcaaacaccg ccggtgtggt ggacccacat
     5641 ccacgccatg agcgacgacc ccgcagcgct cgcccaaggc gtgcaagccg cactggacgc
     5701 caccgccatc ccagccccgg cgccaccagg tcagcagccg ccgatcgacc tggacaccgc
     5761 cggcatcgac caggccctgg gccgcaaggg caccgccgac ggcggcatct acaagttcag
     5821 catcgcccgc aaggagacca tcaccgacga cgggcatgtc cttccgccca cgttcggggt
     5881 gaccaccgcg atcaacttcc agccactcgg cggcgggcgg gccgcgatca acggtgactt
     5941 cgtgatgacc gcacccgagg tccagaaggt gatccaggcg ctgcgtacag gcgggatcga
     6001 cctggtcgaa gtgcacaacc acagcctcac cgagcaaccc cgcctgttct acatgcactt
     6061 ctgggccgtc gacgacggcg tcaccctcgc caaagccctc cgccccgcgc tggacgccac
     6121 caacctgcaa cccccaggct gataccactc acgccgacag cgtttccggc cccgtcgtga
     6181 cgatcggcgg ggccggacaa gcaccatgac aacgagcatg acaacgggaa ggagcgcagg
     6241 atgcggccac gcaccgtttt ggactggatc gctttcgtgc tactgctgat cggcgcgttc
     6301 gcctgggcgg cgttcgtcac cgacatcaac gtgctggatc gggcactgga acccatcgcc
     6361 gatccgctcg acgacatcgt gttcgtgctg atcggactcg cgggcctgta ctggatcggc
     6421 cgcgtcgtcg tcggagaccg aacacatcag tgagcaactc caccgatcca gcgcacgagc
     6481 gaccatcgac gggatcggca gcgccgcggc aggcagggca gcgggcaggg cagtgggtgt
     6541 tgctgtccta ccgcatgccc cgcgagccgt ccaccccgcg gatcacggtc tggcgcaaac
     6601 tcaaacgcct cggcgtcgcc caactcggcg acgggctggt cgcgctgccc gccgacgccc
     6661 gcacccgcga acacctcgac tggatcgccg acgagatcct cgccgccggc ggcaccgccg
     6721 gcgtgtggct ggcccaacca accagcctgg cacaggaacg ccgcctggca cagaccatgg
     6781 ccgccgcccg cgccgccgag taccgcgccg tgctcaccga agccgaacaa gcgcgctcac
     6841 tcggcgaggc cgagcgacga cgcgccctgc gcaccctgcg cgccgagctg cggcgtatcc
     6901 accgccgcga ctacttcccc ccacccgaac gcgacaccgc gcaggccgct gtggacgccc
     6961 tgcaccccga ccaccacacc gaggagaccg catgaagtgg gccacccgcg aacacatcca
     7021 catcgaccgc gccgcctgcg cctggctcat ccgccgctgc atcgacccgg acgccgcctt
     7081 cgtgttcgtc accgaccccg ccgacgtccc cccagacgcc accccgttcg acatgcgcgg
     7141 cgtcgacctc ggccaccacg gcgacgactg cagcttcgaa accatcctgc gccgccacga
     7201 cctcaccgac cccgtgctct ggcgcatcgc cgaaatcatc cacgaagccg acctcgacga
     7261 cgaacgctac gacgcccccg aagcccccgg cctcgacgcc atcctccgcg gcctatccat
     7321 gatcggcgac gaccagcaca ccctcaccat caccaaaccc atcttcgacg gcctctacga
     7381 gtactaccac cgcgcccaga tgctcggccg cgaacccgca tgaccgcagg gaacatccgc
     7441 cgcgccaccc tcggcatcct ggccgccctg ctctgtgcaa gcctgctcgg caccgatcac
     7501 cccgcgacag cgaccccctc atcagcggtg cccttgctgg aagaagccac cccaccagcg
     7561 aatgccgtcc tcaccgaacc ggtcgactgg gtgtacctga ccttcgaccg actgatcaac
     7621 acgttcagca tccgggtcac cggccccaac ggccacgacg tcgcccgcga caacgccatc
     7681 gtcaagcacg acatgatctc ccagccactg cacacactca cccagccggg cacctaccgc
     7741 gtcacctggc aggtcatcga cctcgacggc caccaggcca gcggatcaca cagcttcacc
     7801 atcacccccg gcgtcaccac gacccccgaa aacactgcca ccacaccagc caccaccccc
     7861 cactcagtac cgccgacagc gccaccagcc accaaccagt ccacgatcac cacgccgctg
     7921 gccgccacga tcgcactcag cctcctggca ggactaaccc tcctcaccat tcgtcaccgt
     7981 cgacgcgtcc gcgcatcacg tgcgcagcgg ccagaccgga catgacgaca accgcagtca
     8041 cgagacattc ggtcggcata gctcccgtag tcctggccta ccagcgcgaa agccaatgcg
     8101 gtgtcagatt ccaacaacac cagagccatc gactcaccgc cagcctggcc gtgagaagct
     8161 caacaagctg acttgacagg gaaccgcaac ggggcgacca gccgttctcc aggtgcgagc
     8221 tgcttccacc actgggcggg gatgtcccac ggtgagaccg tggcgatcat gcggtcgtac
     8281 ggggcgtggt cggggtagcc gagcccgccg tcgccagtga tcacgtgcac gtcgccgtag
     8341 ccggcggcgg ccagcgcttg tgaggctttc gcggtcacgt ccgggtcgac gtcgatggtg
     8401 gtcaccaggt ccgcgcggcc ggtcaactgg gcgagcaggc tggcgttgta accggtcccc
     8461 actccgatct ccaggatgcg gttgcccggc tggacgtcga gttggtcgag catcgcggct
     8521 actagccaag gtgccgacgc gcaggacaac gaccggccgt cctcgaaccg gtgggtgacc
     8581 accgcctgcc acgggtcgta agcgaccgcc aggtcggcgt ccggcacgaa ctcgtgccgc
     8641 ggtgtgtcgc gcaaaacccg ctcgacgtcg ctgtgctttg cgtgcccggc cttctggatc
     8701 ctctcgacca ttgccgcacg tagcgcttcc ggcgaagtag tggtggtgtg catcgttcct
     8761 tcgtatcaac gatcgtcggg ttggcgggca tcgttagtga tcgacacggg ctgtttctcg
     8821 ggccgaggaa gcaaacccgt tgtggtgcaa cggcttcact aggacccgcc ctacgggttc
     8881 gctggagcgt tgacgttgca ggacatcgtc ttcacgctgc gtgccatggc ctcttcggcg
     8941 caggctagtg ctgtcgtgag gtctgccagc agtgtggccg ggagcgtgcc gctgccgagc
     9001 gcgcacgctt cgaccgaatc ggacaactcg cgcgcttggg agtcggtgag cagctcgcgg
     9061 caaccattgt gggcgagtac atcgcgagcg acgtatccgt ctcgtgtcgc ggcggcgtag
     9121 tcgatcagat caacggcgat ctggtgcacg ggtggatcgt caacggtgcc gatggcgtcg
     9181 atgaaggaca acccgagccg tgtgtggaag accgccaagc cgggcgcgga ggtgtcgagt
     9241 cggtggtact ggttcaggag cgtgggcaga tcggcgacgc ccgaggcgcc gtggcactgg
     9301 atggtcaggc aggcggtcac ggcgttctcc caagggtctc ctggtgttgt ctcggcgagg
     9361 agagcgaggg cgctgtcggc gtccccggat acggcgtgtg cgatgaccgc gatctggcga
     9421 ccgtcaagca tccgtcgccc gacgcccttg tacgcgtcga gccgggcgcg tgcctccgcc
     9481 cagcggccgg ctgcggccag agcgcggcca ccggtggcca gcaggactgc ccacagccag
     9541 ctgcggatgt gctggtgcgt ctcggcggag tcggtgaggt cggccgggat ctcgatgccg
     9601 tcgacgatgg cgtcagttcg ggcggagacc gcggtgaaca gggtgtccat gagcgcgaag
     9661 gcgcgctcgc cctgaccctc gcggatgtag aggcgggcga ggttggtgat cggttcgaga
     9721 gcgaggcggg ctacctgcgc gcccaagggg cgggcgcgca ggtagatgtt cacctgctgg
     9781 tggcaccacc gccgggccag ttcgggcagg ccgcagtcgg aggcgatgag cgccgcgttg
     9841 ttgtgcacgg cggcggcttc ggcgaggtcg ccgctgtgct cgacttggcg tgctcggtcg
     9901 cacagctcgg ccacccgccg agccagcggg aggcaggccg ggcgggttcg ggcaacgagg
     9961 gggaagcggc gggcgaactg gccggcgggg tccacgggcg tcactcccag gtgacggtca
    10021 tgggcttggt ggcgcggtcc aggaccacga agccggggtt ggtgtccggc tggggcgcgg
    10081 tgtcgggaat ggcgaatcgg acggtgctgg agcggaagct ctggtcccac gtcgagatct
    10141 cgaccgagac ctgctcggcg agttcctgcg cgttggggcc gtggccgatg acgccgacct
    10201 cgtagcgtcg gcggccgtcc ggatcggggt ctgcggcgcg gatggtgagg tatgcgaggc
    10261 tgccgtcggc ggcggtggtg gccatcgcca ccgaggggaa catcggccgc acaaggccgc
    10321 tttccttcgc ggcgggagcg acctccatgc gcatcagcgg gttgggcagg tggcaagcca
    10381 gccagaggtc cagccattcg aaggattcca tcgggacgaa gtgcacgccg gtccacactt
    10441 cgcaggcagg gctgtcaaag accccggcca gggtgtccgg atcggtggcg tggttgttgt
    10501 ccttgtggat ttgcagcgtc acctccccgg tgccggtgag gtccagaacg cggcgagcgt
    10561 cgtcgccgag gccacgcagg ggcatgaaga tcgccatctc gctgtccagg ctgcgccagc
    10621 cgtcctggtc gcgttcgaag acgatgctgc gagaggcaca accacgcagg cgcaccggag
    10681 ccaccagacg cccgccgggt gtgagctggt cgagccaggc agccgggacc tcgtgggcac
    10741 cgacagtggc gatgacgcgg tcgaaaggcg cggtttctgg gtggccgagt gcgccgtcgg
    10801 cggcgaccgc ctcgacgtta tcgatgttgg ctgcggacag gtgctcgcgg gcgccgtcga
    10861 cgaggtcttc gtcgatgtcg atcgtggtga catgcccgtc ggcaccggtg agggtggcca
    10921 tcagggcggc gttgtagccg gtggccgcgc cgagttcaag cagccgttcg ccgggctgga
    10981 tgccgagctg ttcgagcatc atggcgacga tcttgggctg ggacgcggcg ctgattcggg
    11041 tgccgtcgcc ctcgtgtttg gtgtagacag gctcgtcggc gtacgcctcg accaggggga
    11101 cgtcgggcag gaacaggtgt cggggcacct gccggaacgc ggcctccaca gcgtcggtgc
    11161 ggacggtgcc gtccttgacg aggcggtcgg cgagcttggt acgcagctcg tcggcggagc
    11221 cggtggaagc gtcactgacg gtggttgtca ttgcgggaac cctaacggtg ttggaggtgg
    11281 tcccggctgg tgcctgccgg gtaggcgtgc tgtggaaaac ggtgtcgacg gccagcgcgg
    11341 cgagggtggc ctggtcggtg ccggagagac cggcgcggtt ggcgtggaag atgaagtggt
    11401 gcgccagaac ggcgcgcagg ccccgctcga ggtgtccagc gcgagcgagt tcggcgagtt
    11461 ggcggccggc cgtgtcgaac gctgtccacc aggtctcggg aaccacgtcg ggggcgacgt
    11521 cggcgacctt gtgcgtgttg gtggtcatca gtcggcgcac cgcttggctc aaccgctcgg
    11581 tgtgcggaga gttgttggtg tggggttggg cggtgggccg gagcgcagcc accttgcccc
    11641 agacgtcgcc ctgctcgaac cagtccagcc cggcggcgcg cagcatcgag ctgaacagca
    11701 ggacggtggt ctctctctga cccaaggcag cgggtttcgt ggcacgggcg aggcagtggc
    11761 ggctgtcgtg gtgaaacagc gagtgcgcga tgtccatcgc ggcgggtcca ccgaaggcaa
    11821 gggtttcggg ttcgtagatg ccgcgagtcc agcgcgcgag atgcccatcg gcctgcaggt
    11881 cggacagcag cgtgtcgacc gctttcgtct cggggttgac cgattggtaa cgcagccgcc
    11941 aggcgggtgt cttgcgcagg tgccaccacg tgtcgagttc gccgtcctgc tgggcctggt
    12001 cgagggcggg cacgagcagg gtcgcggcgg tgtgctcggc cgtggtcggg tcggcgaact
    12061 cgaccaggta gtggtgccag ctgtccggca gcatcagcgc ggaatctcct ctcggtcgga
    12121 cggatcaggt tcggacggat caggtgatga gcaggccggt gccccagcct gtcgcgggct
    12181 cgatctcagc ggcgagggca gctaggccga tcccggcagc accttcgagg aagccggggc
    12241 cttcgggaac ggcctgggcg caggcgcggt gcagcatctc ggtggccagc gcgcggagtc
    12301 gggaagcggc cggctccggt gtgtcgatgg cggtgtgagc ggtgatccgg gcgagtccgg
    12361 cgtagccgtg gcacagcgaa gcgtcgctga tcaacgcatc ctgttccggg tcggtcaccg
    12421 cactgatcac ggcttcctcg gcgatctggc ggcgatcggc gtcgtcgagg gccagggcgg
    12481 cgaggtgcag ggtgcgggcg atgcccgctg ttccgtagca ccagctcggg cgtcggctgg
    12541 ccccgctgtg ccgcacgtac atcggcgtcg aacgcgcctc gtctcgggtg accatgtagg
    12601 gccaccggtg cccgctcgga gtgcttatgc gccaggagtc cagccacgcg caaatcgtcg
    12661 cgacggcctg gcgctgcccg tccacggcga tgccccggcg cagggcctgg gccagcagtg
    12721 ccagcgggcc gccgatgccg tgtgctacgc cgaagttgcc gtggcctccg gggaactcct
    12781 cgtccgcgtg gccggtggga ccggtgaggg tccaccaccc cggcagggcc tctccttcga
    12841 ccatcaccgg ttgggtgagc cgcacgaggg cgcccagaac ggccggcagg gcggtgccgt
    12901 cggggtcgtg gtgcagcaga tgggcaccga gaccagcgag gccccgaatc gtgtcgaact
    12961 cggccatctg cggcaacatc ccgacgacgt ccatgcgctc gtgggccttg tcgacgcggt
    13021 tgtgggcgtc ggcggcgatc tgccgggtca agggcgtgag ggcggactgg tacgtgccgg
    13081 gacggactgt ggcggcgccc gcgagggcgc gcgcgactgc cggcgcgccg tagaacaagc
    13141 cggtgctcgc tccggcggtg atcggcttgc tggtgacggc ggtcagccag tcgtgggcgc
    13201 ggtcgaacgg ccgtatcccg gcggctgcca gctcgatgtg cagcagtgcc acaccgggag
    13261 cgccgtgggc gagggattgg tgccaccacg gctcgtccgt gggcaggtgg ggggcgtccg
    13321 gccgggcgag gcgatcggcg atccccgtcg cgtactcgac cgcggcatcc gaggcgaggt
    13381 cggcgttcat cgcggtcctc cggtgcgggc ggcgaaggtc agggccgcgg tccgggccag
    13441 gtaaaggcac accgccttgt cgtcgggctc gatgccgtag gcccgcagga agtgcgtgtg
    13501 cagcaacgag cccaaggcgg cgtccgggtc gacgccctcg gcctcagccc cggacaggtg
    13561 cgctcggtag gcagctacgg tctgggcgcg ctcggcccat gtcgcgacga ccgaagccgc
    13621 acccggcgtg ctgcgcaagg cgcggaaatt ctcggagggg tcggcgaggc attgtgcctc
    13681 ggtgaacacc ggccggggca cgacggtagg aggtttggcc gggacatggt cgaccagcca
    13741 ccgcatcccg gcctcggtcc ctcccatgaa ggcgacggcg atggcggcga agttcgccgc
    13801 ggccagagca tggtcgtgcg gtcgcgcggg ccaggcgagc tcggcaagca cggcgcggga
    13861 gtcagccgtg aagaacgcct cgacggctga tagtgccgca cctgagcccc agcggccggt
    13921 ctccgggtag gaggtcgcga aagcgatgtc gcgcagcagg ccgaggcggc ggagccggtc
    13981 ggcccaggcg ctgacccggc cggccgcctc gccgaacacc actggctcag tgctgaggag
    14041 actgatccgc aagcgcaggt agtgctcgtt gccctcgcgg aatcgcagaa accaccaccg
    14101 cggttgggca tcgccccact ccgccagcag tgcgggcagg tgcttggcga gcacggtgtt
    14161 gtgacgttgc gggtcgccgt agagcttggc gaacagcatg ggggaaccac ccggcgacag
    14221 cccgtgctca cctggccgga cgatccgctg gggcgtcggg cgcggtggcc gcgtcgtggc
    14281 ctgcggctga cagctggcca tgggcacgac gacgtcgtga gcacggccat cgagccatcc
    14341 ggcggcgtcc tcagcgggtc cttcctccag caccgcgtgg gggtgggtac cgaggtgctc
    14401 gcgcagcagg acccggtgtg cgtcctcgac gagatcgagc ggcaaccgcc agtccccgtc
    14461 gaccaggaac accgcctgcg ggaggcggcg gcgggtgcgc cactcggcca gggcgctgtc
    14521 ccaggtcgcc cagctggagg tccggtcggg aaggtcggct gcggccaacc gccaccgggc
    14581 cggggacagc acgatgcggc cgaagcgcag ccgaggaaga aacggcaacg tggccgccgt
    14641 gccccagtcg aagtcggtga cctccgcgca gtgtgcgcgg gtcagttcga ccaggaggcg
    14701 ggccagcggc ggagtgtgtt tgcgtaggtt gagtgcgtgc aagccccacg cttcgaccct
    14761 cgcgccgagg gcgggtgcgg tcagatacag gcggtcgctg tcgcaactga ccgccaagtc
    14821 cgccgccgtg aggaccgccg ttgacgcggc ggtgtcgcgg tgttcggcga ggctgacgat
    14881 ggttggcagg acctgggcgc tgcgggcgac gtgtgcggtg gcggggtcca gaggcgggaa
    14941 tgacaactgg gcctggatta ccccgtcaga cgcgggcggg gcgagcggcg tgatcagcat
    15001 tcggcggtcg tgttcgtcga acaggtgcag gaaacggccg ctgacgacgc cggccgatcg
    15061 cgagactgag gtaacgacga gctggaagtt gccctgcttc agggcttgca ggctcgggga
    15121 gtcgacacgg gcgcacaact cgaggtgcga gggcagccgc atcgagtgca caggcgccag
    15181 ctccagctcg gcgatcaacc tctcgccgag gacgacctct tgctgaccgt ccaacgcggc
    15241 ggcctgggcc aacgccagca gccgttcgtc ccgaggcgtc tgctggggtc gtgtgaccac
    15301 tccgctggtg ccggggtagc cgtcaggcca gccgatcccg ctgtcggcaa tgacctcgag
    15361 cagtggcacc tgtgcgccgg tgccgaaccg ctggtagaag cgtcggtgga agtccgccca
    15421 ggctgccgta ccgctggcgc gggaggtcag gcgcgccagg accagcgcgg cacgttccgc
    15481 ttcgcgggcg actgcgctgg ggagcacgac gtccaggtcc agccgcaggt cgaccgtgac
    15541 tgggctccgc cgtgacggag ccaggcggct catggacgcg gcggcgtcgg tccgtagcct
    15601 gcgccgcgct tccgctgggc tgttccgatg tcgccgcaac atgtcgtgga tgtcgttcag
    15661 cgtcatgcac cgctcggtgg cagcctcgcc gaccgtggcc agctcgcgca ccaagtggcc
    15721 aagtgcgtcg ggctccgtgc tcggcgcatg gaggttggtg acgagcacgc gacgagcgac
    15781 caacgtggcc agcaagccgg tcaccgtgct cccggcggtg ctcgggaact cggcctgtac
    15841 ctgctcgcgc atgtcatcga aaggaatcgg tgtccgcgca gctcgcacgg ccgcgcgcac
    15901 cgggccggtg tagcgaagtt cgacttcgac tgcgccggtg cctcgatggt tgacggtcgg
    15961 ctggtacgga accacaagcc gctcaccgcg caccatcaac gtggagttcg cgacgaggac
    16021 caagcgctcc aggatctcgg cctgaccttc caaccgtcgg atgacctcgg ccagccaccc
    16081 ggcgtcggcc gcagcgtccg cgcgatgatc atcaccccaa cgctgagagg gatccgcgtc
    16141 gaaccgcgcg gcggtgaccc cggcgaacaa gccgttggga gtcggacggc cggtcaaccg
    16201 tgccaggtac cgcagaacgg acagcaccac gcgccgggat tcgcgctcgc tggcaacctg
    16261 agcgccacac aggttgtgga cgcggtcagc aaggacaggg ctggccaggc cgatggcgtc
    16321 acggacggct tcgacctccc acacttcgcg cagccagtcc acccacgcgg tgacggcgtc
    16381 ggccccggtc gcggtcagcg tcggccacgg cggaagtttc agctcgccct ctgcaacagc
    16441 ccggaccaac aggccacccg cggctcgaaa gccgacgcgg tcgggcaagg ccgtggacac
    16501 gggacacctc tccaaagcga cggatggaaa ccggacgccc gcccaagaag cccctggcgg
    16561 gcgtccggtc gctcgtgaca atcaggcggc gctgatgcag gtcgacttct cgcacgtcgt
    16621 cccgcagccg tcatccgtca tgttgatcag atgcgccggg tccaccacct cgaccagcgt
    16681 gatgtcgagg tcgaactccg agcccatctc gacctccgcg gcgggcgtgg ccaccgtggt
    16741 cggcgaccac tccatctgaa ccgtcacaga tcctccttcg tgggttttac gctccgagtc
    16801 ccggcgagtc ggccgtgact tcgcccgcca ggcggaccag cccggaactc gaccgaggta
    16861 ccgagcgctc ccgccagcac acccgcgagc ggaattccat cgaagtggag ggcagtccta
    16921 ccaccacaca cccctcgacg gcacgtcccg gtgaaagacg cttccggata ctcgggctgc
    16981 gccgaagcgg aagctcgccc ggaccgcagc gatatcagtc aaacccctgg tgatcaacga
    17041 tagccagagc gccgacgcgg cgtcgatgag gcggcaatga ggcgtcatca cctctgacct
    17101 gcataaacgc cttttcagag gcggtagtcc gaacgggtac agctcgccga gcgggtgatc
    17161 agccttgacc cgtagctggc tatcgtggca ggtgaccgac ggggtgaggt ggtgttcatg
    17221 agtgaccgac gagatgcctt cgccgcgcgg cgtgagcaga tgggctacac ccaggagagc
    17281 ttcggcgcgg cggtgggcgt ggagttctcc acggtcggac gctgggaacg cggcaccctg
    17341 accccgcagc cgtaccgtcg accgtgtttg gctaagaccc tcgatgtgag cctcgaccag
    17401 ttggatgcgt tgctcacgcc gaaccggcaa gcttctaccg ttgccactga accagccgac
    17461 cctgcggagg ccgacgacat gaaccgtcgt gacctgctgc gcttgttcag catgaccggc
    17521 gcgttgctcg cgctgcctgc tggcgagaca gtactcggcg acgtcgaccg gctcgccgcc
    17581 acagctcacg cgggcacggt ggacacggcg ggagcagcgg agttcgccca gctcaactcc
    17641 cacctgtggc gcgtgtacgc actgtcgccg accaaggccc aggtgctgcc gctggtccga
    17701 gcccaactcg gtgtactcag cgactccttg cgacgaccgc agacaccgac catccgacaa
    17761 cggctctgcg agctgaccgc cgacctcttc cagttggcgg gggaaatctt cttcgacggc
    17821 aaccgataca ccgacgccgc tcactgctac acgcttgcgg caacagcgag caaggaggcc
    17881 gtcgcttccg acctgtgggc ctgcgcgttg accaggcatg ctttcgtcgc cgtgtacgag
    17941 cgccgattcg cggatgccgc gccgatgctc gacgtggccg ccaccatcgc acgtcgaggc
    18001 gaccccagcc tgtcgacccg acactgggtc gccgtggtgc aggccgagac cttcgccggc
    18061 ctcggcgact ttgactcctg ccaacatgcc ctcgacaccg ctgctgaggt ccagcgccta
    18121 cggggccagg tgcacaacgg cggctggctc cggtttgatg gctcccgctt ggctgaagaa
    18181 cgcggaacct gctacgtcac gctgggccgc cacgacctag ctgaagcggc tctggtcgac
    18241 gccctgcagg gcaccttgac cgcccgccgg aaagcaggcg tcctgaccga cctggcgatg
    18301 atcggcgtgc accgtcgcga cccggaccag gtcgtcacct acgccgacac cgtcctgact
    18361 accgcccgcc agacccgctc gggggtcatc gcacagaagc tgcgggtcct tcagccacac
    18421 cttgcttcct tgctcaacga ccaacaaatc cagcgactcg atgccgagat caccaaactc
    18481 gtcggcaacc gcgccgcgtg atggaggacg accgaatgca caacgaccgt ggccgcgtgt
    18541 tccgcgaggc gtggatcgcc ggagtcacca agcactaccc cggtgagccg aagcctggct
    18601 acatcacccc gtgggaccag acccccgact gggaacgcga cgccgcgacc gccgtgtacg
    18661 accaggtcgt cgccttcatc aaggccaccg acggcgccac caccaaactg accccagacc
    18721 agaaaggccg ctttgtggcg ttgtgctgga tcggccagat cttcaagcac ttccccgagc
    18781 cgaagccgtc gtacgtcgcg gactggaacg atttgccgga ctggcagaag gcgacggata
    18841 tcgacatctt cgagcgcatc gaacgcgatg cctgaccagg cgacgatcga cgctgcggcc
    18901 gtcgatgctc gccttgccga gaccgagtac gacgacgctc aggcgtggct acacgcacgt
    18961 tcgaccgcgt tggagccgct cgcagccgag gtctgggtca ccgacccgga gcaccgccac
    19021 gtgctgctcg tgcggcaccg ggtgcgaggc tgggtaccgc ctggcggaac cgtcgagcca
    19081 ggcgagacgc ctcgagccgc agcagcccgt gaactcttgg aggagaccgg cctgctgggc
    19141 gagctgctgt cagtgccggc ggccgtcgct gtccgctctt tccgcgccga ctggacgcca
    19201 acgctgagcc tgtcctacgg agccgtcatc aaccgcgacg cgccactcgg cggggagaag
    19261 ggacagccgc cgaagtgggt cgacctggac gaatcgtggg agagcgtgtt ccccgaggat
    19321 cgcgaccgaa tccgcgcgta tgtgcgcagg ctcgcggcag agcacgcggt cgaggcgcgc
    19381 tgatcctgtc gggcggggct ttagtgtcaa cggcgggcga atcttgaccc cctggcggca
    19441 cctgggttag gcgccacgcc ggggtcagtt ttcacgcgcc gtcgacagct ttagttggtg
    19501 gcggcccctg cggacatgca cagatcgtcc caagcaccat cccgctctgg cgttttcatg
    19561 ggcggtctgg gtcgcacgtc cggacgtgaa cgtccgccgt ttcgtcgttg acatggccgc
    19621 tgatcaggtc cgatcaacgc cgggtagcgt gggtgcgcta gcgaatctgg gagtgattat
    19681 ggcgatacga cgagatgctc tcgcagcacg gcgcgaggct ctcggcttca cccaggaaac
    19741 cctcgcccag gagcttgggg tggagctctc gacaacctga cctcgcctgc gagtgggccg
    19801 ctcacctgga agggagggac gaccgacgaa cgttcagcgg ggtcgccgac ggtgctcatc
    19861 acgggctgct tcctgtcgtg cccgtgaccc tacttggtca gggcgcgcag gcggtggtga
    19921 gcgcggcggc ctgatcggcc ctggtctgca gccaggcggc tggagcactg gtgagggtgt
    19981 ccagggtggc cgtctgcagg gtggcggcca ggtcggtgat ggcgcggccg atgtcggtgt
    20041 cgctggtggt cgcggccagg tcggtgagct cggtggcggt ggtgtgcgcc tggtccagtg
    20101 cggcctgcgg tgcgctgagg tcgggcgggt tggcgaccag tgccagcgcg tcgctacaca
    20161 cctcggcggc ggcgaccgcg ccggtcacgg tgtccgcggc cgaaccggcg gtgtcgccgg
    20221 cctgctggac agcgccgcag ccgctgatcg ccgccacgac gcccacgccg agcagcacag
    20281 aggtccatcg agtcgagatg cgcatgagcg ggttcctttc cggatgggct gggtctgtgg
    20341 ggtggtgccg cccaccgctg gtggggggag tgagcggtgg gcggcaccgg ggcggtcgac
    20401 gcgcgtcagt cgcgcgtcga caggccagtg ggcgaggacg gggccgtctc ggctgcggcc
    20461 gccccggttt gggctggctc ggtcgtgacc gtgtcgggct ccgcaccggc cagcgaatcg
    20521 gcagaggcag ccgctggggt ggccggggtg gtgcgggtgc ggatccagct ggccgtgacg
    20581 gcgacggcga gcaggagggc gaccacggcc agcgagaacc aggtggggat cttgtagagg
    20641 tcgagcagca gcatcttgat gccgacccac accagcacca gggcgaggcc tagcttgagg
    20701 tagatgaagc ggtgcatcag gtcggcgagc aggaagtaca tggcgcgcag gcccaggatg
    20761 gcgaaggcgt tggaggtgaa caccaggaac ggctgctggg tgatggcgaa gatcgccggg
    20821 atggagtcga cggcgaagac gatgtcggtg acctcgacca gcaccagcac cgccaacaga
    20881 ggggtggcca cccagcgccc ggcctggcgc accaggaact tctgcccgtg gtactcctcg
    20941 gtggtgggga tgaccttgcg gaacaggcgc agcacgacgc tgcggtcggg gtcgatggtc
    21001 tcgttgcggt gcacggccat ccggacaccg gtggcgacca ggaaggcgcc gaacacgtac
    21061 aggatccagg cgaaggacgc gatgagcacc gagcccgcgg cgatgaacac cgcccggaac
    21121 accagtgcgc cgagcacgcc gtagaacagc acgcggtgct ggtactcgcg gggaacggcg
    21181 aagtagccga agatgatcgc gaagacgaac acgttgtcca ccgcgaggga cttctcgatc
    21241 acgtagcccg cgaagtactg ggcggcgaac tcgctgcccc acgcccacca cacgatcgcg
    21301 ccgaacccga ggccgagcgc gacccacacc gccgaccagg cggcggcctc gcggaccccg
    21361 accacgtgtg cgcggcggtg ggcgaacagg tcgatcgcga gcatcaccag gatcacgccg
    21421 agcaccgcgg cccacgccca caacggaaca accacagtca agcacctccg gtcacgtcga
    21481 gtgaaaccgg aggtctcccc aaccgccaga gcacgtgcgc tgggtccggt ggcgccggga
    21541 ccgggcagcc atcgaactgc cgtaatgacg atcccggacg tggtgggtac tcccctccgc
    21601 accaccagaa tgacgaaata cggttcgcct gtcaaggctt gactggcgaa ccgtacttcg
    21661 tcaatctgga aatgaggcca gcgcgcggcc tcctcgatcc gtgccgtgga aagcaggtcc
    21721 gctgatgccc gcccagtgca caaccctcgt ctgcgtcgtc gacgccaccg atcccgcgcc
    21781 ggccgccgag ctgcccgcgg cggtcgaact gatcgccgac cacggccacc tcgtgctcgc
    21841 cgtgctgcac ccgccgccgg ggctcacgct caacgcgcgg ctgatcgcct ggcagcaggt
    21901 ccgccgggag caggtcaccg ccgcggcgct cgctcccgcg ctgtcacggc tcccgtcatc
    21961 cgggctggcc gagcggggcg tgcggatcca caccaccgcg tggcatcacc gtcgcgggcc
    22021 gggcggccgg catcggcgcg tggccgccgc cctgctgcga ctgtgccgag tgcacgacgc
    22081 cgacgtgctc gtgttgcccg cccatcctcg cgccgagctc ctcacgcctg cgacctgcca
    22141 gtacctgctc ggcctcactc aacctcggct gcggatccgc cgcgcagacg agcacaccct
    22201 gcccgacgcg atgctggtct gatcacaccc ggtcgagcag ctccccgccg atccggaccc
    22261 cgcgccgaca gcggcatcga gagtggaagg aatgccttat ggtcggcccc atgcggcctg
    22321 ccgaaccccc acccgaccac gccctcccca ccccagcggg ctcggatccc accgactccg
    22381 gcacggtgga ttctggcgtg gtggatgctg gtgcggaacc ggccgacgcc gccgcgtcgc
    22441 agacgccagg gtcgtggatg ttcctgagca accacgccca cgtgctgctc tgcctggccg
    22501 ccgacccgca ccagaccctg cccgtcatcg cccagaaggt cggcatcacc acccgcgccg
    22561 tccagctcat cctcaccgac ctcatccagg gcggctacat cgagcgcacc aaagtcggcc
    22621 gccgcaacca ctaccgcatc aaccccgacg gccatctgcg ccacccgctg gaagcccacc
    22681 accgcatcgc cgacctcatc accgccgtcg gtcccgccac ccctgacgat gctcgtgatg
    22741 cttcggctga cggcgcctcg actcctccgc gtcgtcgccg caccggataa ctcgccaccc
    22801 ttggtaaacg aaccacagtt cgtcattctc gacgttgagg gggagtacct caacgaccaa
    22861 gccccgcgtc gtcaacacga tctggccgac ccggatccgg cgcaggcacc cgccgcccca
    22921 ccgcgcgggt ccaggaaacc tcacgccacc gacgccagca ccaccaagca cgccctggca
    22981 agggctacgt ggcgtggccg ggcggtgtgc ggacaggacc tcgcgacgac cagcgcccct
    23041 ctcgcttcgc accccacact gacacgccac ccgggacggc gtgtgttcat cgtggcgggc
    23101 ggggcggcac caacgctgcg caggtgatga ccaacgccag cagaatgagt gccgtgacag
    23161 cgatgtcgat gaggaatccg gtgagcatgg tgaacatggt cagtccttct caatcacgtg
    23221 ctgctcggct cggcggcggg tgcgcaggct cgccgcgatg acgacggcga ggatggccac
    23281 gatgacagcg agggagaccg gcgtggggat ctgcggggtg gccggccaga ttccgtgggc
    23341 ccagtgcaac accagtttca gaccgatgaa cgcgagaatg accgccaggc cgtggttgag
    23401 atagacgagc ttggccagcg tggcgtggag cacgaagtag agcgcgcgca ggccgagcag
    23461 cgcgaaggcg ttggtggcga ataccaggta ggggtccgcg gtgatgccgt agaccgcggg
    23521 gaccgagtcc acggcgaaca ccacgtcggt cacgaacacc gcggcgacca ccaccgcaag
    23581 cggcgtgagc gcgcgtcgtc cgtgctcccg tacggtcagc cgggtgcctc ggtagtcgtc
    23641 ggtgacgggc atgaacctgc ggagcagtcg cacgatacgc atctgggata cgtcgcggcc
    23701 cgcgaaggcc gaaccggtgt gcacctcgtg caggatcttg cccgcggaca cgagcaggat
    23761 caggccgaag aggaggaacg cccaggtgcc tgcctgcagc agcgccgcgc ccgccgcgat
    23821 gaagatgccc cgcaggacca gggcaccggc gatgccgtac agcagcaccc gttgctgaat
    23881 gggggacggg accgcgaacc cggccaggat cagcatgaac acgaacaggt tgtccaccga
    23941 cagtgacttc tccaccacga agccggtgat gaactccagt gccggcccgc tgtcgaacac
    24001 cgcccacagc cagatcccga acaggacggg cagcgtgaga tagaacaccg accagccaat
    24061 cgcttcccgt atcgacacct cgtggggacg gcgggtgacg gcgaaatcgg tgacgaggag
    24121 gccgagtatt acggcgatgc tggcgaccca caaccagggc gacccgatcg acgaggaccc
    24181 caccgagtcg gcgggcgcgg ccacggacag agacgacacc acgggatgaa agggcacgaa
    24241 gacctccgcg cacggacgac gttcgaggtc tccttcaccc tggtgagggc ggtcgcccgg
    24301 ggacaccatg gggtgtccgt attgaccagg cagacactta gggaagtact cccctctgca
    24361 cgcagtgtca ctggccggaa tgtggctgtc aaggttgatc gggggtggat ctaggatcgg
    24421 tggcgtgagg cgcgccgggg tatggcagtg gctggacggt cacgtcgacc atgagcgggg
    24481 ggtgggggtc gctgctggtg gggtggtgtc gcaggccccg acgaccgtgg tcatcgagcg
    24541 gctgctgcgc acgctcggcc ggcccgagca gcgggtgccg gtgatcctgg tggccggcac
    24601 caacggcaag agcacgaccg cccggatcct ggccgcggtg ctggcgggca gtggactgcg
    24661 ggtcgggttg tacaccagtc ctcatctgca ccggccgcag gagcggatca ccatcgatgg
    24721 tgtcacgatc accgacgacg agttggcggc ggtgctcgac ccgctggtgg cggacgagcg
    24781 caccgcgtca gagctggggc ggcccagttg gttcgaattg atgaccgcgg ccgcggtggg
    24841 ctggttcgcc gaccaacgtg ttgatgtcgc ggtggtcgag accggtctgg gtggcagcgg
    24901 cgacgcgacc gccgcgctcg gcgccggcct ggtggtggtc acgtcggtgg gcgtcgacca
    24961 cgtcgagtac ttcggtgaca cgcggtggga caacgccgtg gctgaggctg gcgcggttcc
    25021 tgagggcgcg accgtggtgc tagccgaagc ggacccggcc atgcacccgc cgttcctggg
    25081 ccgccgcccc tcgcgcgtgg tgaccgtgga tcgtgacttc ggcgtggccg ccgacgcgcc
    25141 ggtcgcggat ggccggacgg tgtcgctgtt cacgcccggg gcgacttatg acgacgtttt
    25201 cctgcgtctg ctggcaccgt ggcaggcggc gaacgcggcg acggcgttgg ccgccgccga
    25261 ggtgtggctg gcccggccgg tggccgacca ggtggtgcgg gcggtctgcg gggcgctgcg
    25321 ggcttcgggc cgctttgagc ttgtccacac ccccggccct gtgctgatgg acggcgccca
    25381 caacgaggaa gcggccaccg cgctggcacg ggcgctgcgg gagcggttcg acggcgtctc
    25441 ccgcaccgtg gtggtcggta tgaccgggac ccgcgcgccg gaggcgtttc tgagtgccct
    25501 gggggtcggg gctggtgact gggtgatctg cacctcgccc cggacaccgc gagcggtgcc
    25561 gctcgccagg ctcgccgccg ccgcgcgggc ggtgggcgca ggatcggtcg cggtcgaggc
    25621 ggatgtgggt gatgcggtgc gccgcgcggc ggcggcgaat gatagcacgc tcacggtagt
    25681 taccgggtcg ctctatgtga tcggcgaggc gctgcccgtc gtgcgagcgc tggtgacgtg
    25741 accacccgtg ctgcccgggc tgagcgccgc gcgtgctgat cgggaagaga gggtacgaga
    25801 tccggtctcg aaatgggtcc ggcggcgcgg gggcaacggt gatcgcgcga gccggtggtg
    25861 tgtcagactg cagtggtgag gggtgaacgg gtgatgtcgg atcaaccagg catcgcgcct
    25921 gagcgcgtgg gactcgatgt ggaacgcgct gctggcaccc tgcgcgcggg tgggctggtc
    25981 gcgttcccga ccgagaccgt gtacgggctc ggcgcggacg cggagaacgt cgacgcggtg
    26041 gagcgtgtct tcgccgtgaa ggggcggccc tcgacgcacc cgctgatcgt gcacctcagc
    26101 ggggcgcgtc agctccccga ctgggtcgcg gaggtgcccg acgcggcgcg ccgcgtcgct
    26161 gaccgtttct ggcctggccc ggtgaccctg gttcttcgtc ggggccgccg tgttccccgc
    26221 gcggtcaccg gcggtctgga gacggtcgcg ctgcgggtgc ccgaccatcc ggtcgcccgc
    26281 gcgctgctca cggcgttcgg tggcggtgtg gcggcgccat cggccaaccg tttcggctcg
    26341 gtcagtccca cggcggctgc tcatgttggc gacgggttgg gcgccgacgt cgactacgtg
    26401 ctggacggcg gcccctgtgc ggtgggtgtc gagtccacga tcgtcgacct caccggcgca
    26461 cctgcgatac tgcgcccagg cggcgtgaca cgagaggatc
//
