LOCUS       NZ_CP015163            22029 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis albispora strain WP1 chromosome, complete genome.
ACCESSION   NZ_CP015163
VERSION     NZ_CP015163.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis albispora
  ORGANISM  Amycolatopsis albispora
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Complete genome sequence and analysis of deep-sea sediment isolate,
            Amycolatopsis sp. WP1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2016) Zhejiang University of Technology, College
            of Pharmaceutical Science, Chaowang Road No.18, Hangzhou 310014,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera assembler v. unspecified
            Genome Coverage                   :: 138.17X
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:57:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,537
            CDSs (total)                      :: 8,472
            Genes (coding)                    :: 8,394
            CDSs (with protein)               :: 8,394
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 26 of 78
            Pseudo Genes (incomplete)         :: 54 of 78
            Pseudo Genes (internal stop)      :: 6 of 78
            Pseudo Genes (multiple problems)  :: 7 of 78
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:20:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4870960
            Orig. end                         :: 4892989
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015163.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22029
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="22"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22029
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22029
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12029](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12029
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(127..825)
                     /locus_tag="A4R43_RS22910"
                     /old_locus_tag="A4R43_22695"
     CDS             complement(127..825)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670623.1"
                     /locus_tag="A4R43_RS22910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22695"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_113694219.1"
                     /transl_table=11
                     /translation="MTSGDPSAVLAGDRGTLARAGTAERVAQILRQRITEGVFLPGTRL
                     SEPAISGALGVSRNTLREAFQLLAHERLAVRELNRGVFVSVLTAPDIEDLYRIRRMVEC
                     AAVREAADREDLVLTGLEAALAEGKQAALDEDWRAVGTASIRWHQALCELSGSDRVAGT
                     MRQVLAETRLFFVLTESTQAFFEPYLARHEKIIGHLRRRRFDLAEQALERYLRDAERQL
                     LAAYHRRETR"
     gene            complement(822..1613)
                     /locus_tag="A4R43_RS22915"
                     /old_locus_tag="A4R43_22700"
     CDS             complement(822..1613)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-161). E-value: 2.2e-07. Score:
                     22.9. Matches aSDomain:
                     nrpspksdomains_A4R43_RS22915_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004561815.1"
                     /locus_tag="A4R43_RS22915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22700"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_113694220.1"
                     /transl_table=11
                     /translation="MGRMDNKVVVVFGGARGIGLATVKEFLAEGAVVRSSDIREPAEDL
                     GHENFTHTEVDATDESAVQSFVEQVLGEHGRIDVLFSNVGIHLGKPLPETTLAEFDHIF
                     AVNVRTAFLAARAVLPHMIAAKAGSIVLTSSNGGMMGRPADPVYNATKHALVGLAKSLA
                     VAHAHLGIRVNTVNPGAIDTDMLRSTLASPDEFEAKQHALTASTPAARVGEAWEVAKAV
                     LFLASDESRFVNGAVLPVDGAKAAGAMPGNRYSLDFELGVR"
     aSDomain        complement(1131..1592)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS22915_PKS_KR.1"
                     /evalue="2.20E-07"
                     /label="A4R43_RS22915_PKS_KR.1"
                     /locus_tag="A4R43_RS22915"
                     /protein_end="161"
                     /protein_start="7"
                     /score="22.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVVFGGARGIGLATVKEFLAEGAVVRSSDIREPAEDLGHENFTH
                     TEVDATDESAVQSFVEQVLGEHGRIDVLFSNVGIHLGKPLPETTLAEFDHIFAVNVRTA
                     FLAARAVLPHMIAAKAGSIVLTSSNGGMMGRPADPVYNATKHALVGLAKS"
     CDS_motif       complement(1521..1589)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R43_RS22915_0001"
                     /evalue="1.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="A4R43_RS22915"
                     /protein_end="31"
                     /protein_start="8"
                     /score="11.7"
                     /tool="antismash"
                     /translation="VVVFGGARGIGLATVKEFLAEGA"
     gene            complement(1615..3306)
                     /locus_tag="A4R43_RS22920"
                     /old_locus_tag="A4R43_22705"
     CDS             complement(1615..3306)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229601.1"
                     /locus_tag="A4R43_RS22920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22705"
                     /product="hydantoinase B/oxoprolinase family protein"
                     /protein_id="WP_113694221.1"
                     /transl_table=11
                     /translation="MSVDPILVGVIGNRLHSILAEQQNALVNTAFSAVVRESLDLACAV
                     FDSRGEMIGQSVGGTPGHINAMATGMHHFVAAFPPERLEPGDVLLTNDPWQTAGQINDI
                     TVATPVFHRGRVIAWFASCCHAPDIGGRLVSAEANEVFEEGLRLPIMKFLRAGEVNAEL
                     EAIIRANVRTPEETIGDLYAQVAGNEVGAASLVRLAEEYGLDSIDEIAAEIMNRSERAL
                     RDAIAALPDGTFRSELRTDGFGDEEVRLKVALTVRGEDIDIDFAGSSPQSRHGINVVLN
                     YTRAYASFAVKAAIAPEVPHNAGSFRPVHVTAPAGSVLNCLPPAPVASRHLIGHFLPSL
                     LIGALDGRMAHSADALWMTIWRGRSEPDGREFMLNVFQTGGIGARTTKDGLNTTGFPSG
                     LRATPTEVIETMAPLVQTRRVLRTDSGGAGTYRGGLGQSTTVVARGNISWSVNGNVDRT
                     TAPATGVHCGHDGAPGRFGLADGTALPGKRRVQLAPEAEVDVVLPGAGGYGDPRERDPE
                     RVLADVVDGYVSIEAAREVYGVEIRYTGRPDALVRLPADYQIVERD"
     gene            complement(3303..5339)
                     /locus_tag="A4R43_RS22925"
                     /old_locus_tag="A4R43_22710"
     CDS             complement(3303..5339)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150523.1"
                     /locus_tag="A4R43_RS22925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22710"
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_162788559.1"
                     /transl_table=11
                     /translation="MMALRVGVDIGGTFTDLCVLDDSGVVAIGKTLTTHDEPARAVGEL
                     LTATLTQPSQVDKLVHGTTLVTNALIERKGAKLALLATEGFRDVLEMRREHRYELYDLE
                     IELPEPLVPRHLRFDVPERILADGSVRTPLDEDHVARLGTELAERGIEAVAICFLHSFT
                     NPEHERRARDVLAEVAPGLRVALSSEVVPEIREFERASTTAANVYVQDLTERYLRDLEQ
                     RVHRAGIGPAPHIMLSNGGIATVDTAARYPIRILESGPAGGALAASAFGAAAGEADLLA
                     FDMGGTTAKLCMISGGAPLVTHEFEVDRVYRLLPGSGLPVKVPVTDMIEIGVGGGSIAR
                     INALGLLTVGPDSAGSEPGPVCYGRGGTEPTVTDADLVLGYLDPGYFLGGEMALDLEAA
                     RAVIREKIAGPLGVGLAEAAYGIHAHVNEDMANAARAHAVERGKDPARLPMFTFGGAGP
                     VHGVGVARALGARQVVAPPAAGVMSAVGFLTAPLAFDFVRTSRAGVDELSWSEVDALFA
                     EMEREGEELLKASGVDIVTHSRIAEMRYQGQGYEIRVPVRRGEWPASLVNDFTETYREL
                     YRRTGPDVGVEVLNWRVVSSGPVPRVNLRLNVEPGEGEARKGSRQAYFPGGFVDTAVYD
                     RYLLKSGDRIDGPAIIEERESTLVIPPGASCTVRADASLVVTP"
     gene            complement(5336..6988)
                     /locus_tag="A4R43_RS22930"
                     /old_locus_tag="A4R43_22715"
     CDS             complement(5336..6988)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082801.1"
                     /locus_tag="A4R43_RS22930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22715"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_113697812.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.8e-48, bitscore:
                     162.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-25, bitscore:
                     87.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVVSHAKPKSGADRLADALGELGVQVAFGLPGVHNLPIWEALAD
                     TGIQLIGVRHEQTAAYAADGYARATGKLGVAIVTTGPGAANTLAAVGEAQASGSPVLVV
                     ATDIPSTLRRPGMVRGVLHETSDQAALFAPLTKAQYTAGGTGEIAGTALTAARLALRPQ
                     SGPVYLGIPTDFLSATAQRVPDTPDRTPVAEPLDLGRARELFERAERPLIWAGGGALRA
                     GAGAVIGELAEKLAAPVLTTFAARGLLPPEHPCLAPNSVHAPEVGALWDEADLVLGVGT
                     DFDGLMTQNWLMPQPPTLVTVNVDAADAAKNYQPDLNLVGDARTVVTALLGELPPKEGL
                     DKLTARLRRMSAAVRRRIREDEPQAADFLGTLEEVLPEDTILVSDMCIAGYWIGGFHRI
                     PAPRKLAYPMGWGTLGFGFPAAIGSAAAGAGRAVCITGDGGFLYGCGDLATAAQENLPV
                     TVVVVEDGGYGMLRYDQTHSGLPHRGVDLVGPDFVALGKSFGIRAERVKGFGRAFRRKL
                     GAFIQADEPNLMVVEAAMRPPLNTSPRWYRKER"
     gene            complement(7030..8184)
                     /locus_tag="A4R43_RS22935"
                     /old_locus_tag="A4R43_22720"
     CDS             complement(7030..8184)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641035.1"
                     /locus_tag="A4R43_RS22935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22720"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_113694222.1"
                     /sec_met_domain="DAO (E-value: 4.3e-65, bitscore: 219.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKLPEEAGVVVVGGGVIGTSCAFHLAEAGVDVLLLERGALGAGS
                     TAKAAGGVRSSFTSRVNIELGLRGLAEFERFPARFGQEIDFRRDGYLYLITDPADLPRF
                     EAGVALQNSFGVASRVVEPAEAKQHNPLISVDGVHAAVWSPGDGRATPDAVVQGYARAA
                     RALGATLCTGVEVDGIERDGDRIRAVRTTAGVVRTGVVLCAAGAWSARIGALAGCPLPV
                     RPERRQVVFTGPVPGRPDSVPLTVEMPSAFYLHPEGDGLALSFPGTPEADFDTRYEPGE
                     WLPALAELVERRAPSVLDAGIRAAWAGLYEMTPDRNQVVGEAAGVSRFLYATGFSGHGF
                     QMGPAVGEVMRDLYLGRAPSIDVSTLDVRRFDGGGTGGGEHNIV"
     gene            8295..9665
                     /locus_tag="A4R43_RS22940"
                     /old_locus_tag="A4R43_22725"
     CDS             8295..9665
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008374 - O-acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150531.1"
                     /locus_tag="A4R43_RS22940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22725"
                     /product="wax ester/triacylglycerol synthase family
                     O-acyltransferase"
                     /protein_id="WP_113694223.1"
                     /transl_table=11
                     /translation="MPLMPITDSMFLMVESREHPMHVGGLQLFRKPEDAGPDYLSEIRR
                     RLLDRSEVRRAFRRRPARPVNTMGYAAWAEDVELELDYHFRHSALPQPGRIRELLELTG
                     RWHSTLLDRHRPLWEVHLVEGLRDDRFAMYSKVHHALMDGVSALRQMQATLSESPDERD
                     SPPPWGGPAATKGVRRSRRDPVSLLTGARQSLSQLAKLPGAAVKVATEAFREHSLTLPT
                     QAPKTMLNVPIGGARRFAAQSWSLDRVRQVATAAGVSRNDVVLAMCSGALRDYLIEQRA
                     LPDTAMVAMVPVSMRKPVETGASSGNAVGALLCNLATDRSDPAERLKLIHQSMRNAKRI
                     FKDLTPVQALILSGINVAPLGASTIPGFVNNTRPPFNLVISNVPGPRKTMYWNGAQLDG
                     VYPASVLLDGQALNITLTSNGDNLDFGITGCRRSVPHLQRILTHLDTALAELESAVA"
     misc_feature    complement(9748..9757)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.18"
                     /tool="antismash"
     gene            9835..9930
                     /gene="pqqA"
                     /locus_tag="A4R43_RS22945"
                     /old_locus_tag="A4R43_22730"
     CDS             9835..9930
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005456332.1"
                     /locus_tag="A4R43_RS22945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22730"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_113694224.1"
                     /transl_table=11
                     /translation="MIETATEVWTTPDFVEYETPMEVTAYAARME"
     misc_feature    9852..9867
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.23"
                     /tool="antismash"
     gene            10001..10693
                     /gene="pqqC"
                     /locus_tag="A4R43_RS22950"
                     /old_locus_tag="A4R43_22735"
     CDS             10001..10693
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150533.1"
                     /locus_tag="A4R43_RS22950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22735"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_113694225.1"
                     /sec_met_domain="TIGR02111 (E-value: 4.2e-84, bitscore:
                     280.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPLSHEEFAAALRGLSHRYWGTHPFHHRMHAGELSERELRIWA
                     ANRWYYQRMIPQKDAAIISNCPLPEVRRQWLPRLVYHDGATAGEGGIERWLRLCEAVGL
                     SREEVLDERHVAPGVRFAVDAYVTFARTKPWVEAVASGLTEMFSGHLMKRRVADMLANY
                     AWINRTDLAYFTNRIDAVSGEGQATVDLVLRHCETRAQQEAAIAALSFKCDVLWSILDA
                     IERAAAKE"
     gene            10690..10947
                     /gene="pqqD"
                     /locus_tag="A4R43_RS22955"
                     /old_locus_tag="A4R43_22740"
     CDS             10690..10947
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670611.1"
                     /locus_tag="A4R43_RS22955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22740"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_113694226.1"
                     /sec_met_domain="PqqD_RRE (E-value: 5.4e-23, bitscore:
                     79.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.2e-12, bitscore: 45.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVKPRLRRGVRLTYDKVRETHVLLYPEGVLVPNKTAAAVLELCD
                     GESTVADITAALGKHYRGVQEADVNGVLSRLVERRVVEWL"
     aSDomain        10699..10938
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R43_RS22955_PqqD_RRE.1"
                     /evalue="1.80E-25"
                     /identifier="RREFam006.1"
                     /label="A4R43_RS22955"
                     /locus_tag="A4R43_RS22955"
                     /protein_end="83"
                     /protein_start="3"
                     /score="79.5"
                     /tool="antismash"
                     /translation="KPRLRRGVRLTYDKVRETHVLLYPEGVLVPNKTAAAVLELCDGES
                     TVADITAALGKHYRGVQEADVNGVLSRLVERRVVE"
     gene            10938..12029
                     /gene="pqqE"
                     /locus_tag="A4R43_RS22960"
                     /old_locus_tag="A4R43_22745"
     CDS             10938..12029
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005456329.1"
                     /locus_tag="A4R43_RS22960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22745"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_113694227.1"
                     /sec_met_domain="PTHR43273 (E-value: 2.6e-30, bitscore:
                     104.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.5e-22, bitscore: 79.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.9e-05, bitscore: 22.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.4e-10, bitscore: 39.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.1e-11, bitscore:
                     42.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVKPAEPPLGMLAELTHRCPLHCSYCSNPIELVTRERELDTGQW
                     LSVLSQARELGVLQVHLSGGEPLARPDLPELVSHASELGCYVNLVTSGLGLTEKRLDDL
                     ADRGLAHIQLSVQGADAERADRLAGTRAHEHKLTAAALIKRAGLPLSVNVVLHKQNHDQ
                     LAGIIALAERMGADRLELANTQYYGWALKNRTALMPTREQLAAAEPVVRAATERLRGAM
                     EVIYVVADYYEPYPKPCMYGWGARQLTVAPDGDVLPCPAATAITTLELDNVTRKPLHDI
                     WYRSSSFNAYRGEDWMSETCRSCDRRGADHGGCRCQAFLLTGDAAATDPVCSRSPDREL
                     VDLILAAPPPAVEPELVMRRVAR"
     gene            12026..12889
                     /gene="pqqB"
                     /locus_tag="A4R43_RS22965"
                     /old_locus_tag="A4R43_22750"
     CDS             12026..12889
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="A4R43_RS22965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22750"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_113694228.1"
                     /transl_table=11
                     /translation="MKVLLLGTAAGGGFPQWNCACSLCTSDAPHRTQDCVAISADGRGW
                     YLLNASPDIRAQILGSPVLRAGPGPRETPLRGALITDAELDHTLGLVMLREAPSFGVWG
                     PDAALHAMRGALPVGRYGDWRFSPVAPEIGGLRVSALPVSDKKPKYARDSTMDGPWVVA
                     YRIEDPATGGVFVYAPCLAAWPPGFDEFTDGADYVLLDGTFYGADEMSGATRAGVGTQA
                     QRAMGHVPISGADGSLARIRDRPGPRWAYTHLNNTNPALAPDSPEHKEILAAGAELPLD
                     GTLLDL"
     misc_feature    12371..12373
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12886..13860)
                     /locus_tag="A4R43_RS22970"
                     /old_locus_tag="A4R43_22755"
     CDS             complement(12886..13860)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499287.1"
                     /locus_tag="A4R43_RS22970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22755"
                     /product="aldo/keto reductase"
                     /protein_id="WP_113694229.1"
                     /transl_table=11
                     /translation="MRTTTLGRSGLEVSRIAFGTWQLGGDWGAFDEDTAIEAIRHAREL
                     GVNFFDTAQGYGFGKSEALLGKALREELTRDRDSLVIATKGGIYPGEQRSRDAGRKSLR
                     SGVEESLRHLGLDHIDLYQVHWPDADTPAEETASALQELVDEGKIRHAGVSNYDTRQLA
                     AFDATRPVETLQPPYHLFRRAIEQDPMPYAREHNIGVLAYSALGSGLLTGALTPDSTFD
                     SDDWRSKSSAFQGENLRRNLEVVDRLKEFAATKNITVSQLAIAWVLAQPGVHVAIVGAR
                     KPKNISESLAAADVDLSAADLAEIERLTAGAVQVEGANPEGVA"
     misc_feature    complement(13907..13920)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.76"
                     /tool="antismash"
     gene            13954..14472
                     /locus_tag="A4R43_RS22975"
                     /old_locus_tag="A4R43_22760"
     CDS             13954..14472
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005447463.1"
                     /locus_tag="A4R43_RS22975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22760"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_113694230.1"
                     /transl_table=11
                     /translation="MPEKAPLLELRVLAHPLRLRILSLLTGTAMSAAEAARELNETQAN
                     VSYHLRRLHEAGLLEVAEEVRIHGGLAKRYRHVPGRGPAWDHGDREGEQLFAEALAGEL
                     RRRTEHRLPSGRSAITDAEVWLSPDDWARAVRLAHELGELLHDAARPPRTPETQRVSAT
                     IALFEMTAS"
     gene            14469..15728
                     /locus_tag="A4R43_RS22980"
                     /old_locus_tag="A4R43_22765"
     CDS             14469..15728
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082806.1"
                     /locus_tag="A4R43_RS22980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22765"
                     /product="MFS transporter"
                     /protein_id="WP_113694231.1"
                     /transl_table=11
                     /translation="MSLREPLRHRSFRWLLAGRTGAELANAIAPVALAFAVLDLTGSVV
                     DLGLVVGVRSLANVILLLFGGVLADRLPRAVILQGTGVAAALTQGLIAASVLGGFASIP
                     LLLGLSALNGAVSAMSLPAAASLTPQTVPATLLTPANALARMGANTGRIIGAALGGVLA
                     AGVGAGWAIAVNAVVFLLSAAGYRGVRIVRRVREERSNPLKDLAEGWREFTARSWVWVV
                     VAQFTVVNAVIMGSHAVLGPKVADDTVGRAGWGFVLAAETLGAFVGGVLAARWQPRRAL
                     LIGVAVISVEAVPLVVLAELPSLVPLLAAMFLAGIAIEQFVVAWDVSLQENIPEDKLAR
                     VYSYDMLGSFIAMPVGEIAAGPLAARFGADVTLLAGALLVLVSTALALCSAQIRSLTRK
                     AAQPASVTGPIPSTDHTPTP"
     gene            complement(16334..17743)
                     /locus_tag="A4R43_RS22985"
                     /old_locus_tag="A4R43_22770"
     CDS             complement(16334..17743)
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155859.1"
                     /locus_tag="A4R43_RS22985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22770"
                     /product="amidase"
                     /protein_id="WP_113694232.1"
                     /transl_table=11
                     /translation="MNESGTLLTASELVAAYGSGELSPVEATQASLDAIAERDGELNAY
                     CLVDADSALEQAKLAEQRWREGNPIGWLDGVPTSIKDMFLTQGWPTQRGSRCIDPAGPW
                     EVDSPVTARLREHGLVLLGKTTTPELGWKAVTDNTLNGITRNPWDPALTAGGSSGGSAA
                     AVAAGMGELSVGTDGGGSVRIPASFCGIVGFKPTHGRIPLYPASPFGPLGHAGPMARSV
                     DDVALLLDVLALPDHRDPSALAPPVSSYREAVRRDVRGVNAAYSANLGYVDVDPEIARI
                     TLAAVAAVNEAGLRIEETDPGFADPLDAFDVLWSTGAAKWLDTFPEGSAELIDQGLRRV
                     WEHGHTFSAGDYLEASAVRAALGIHMGEFHLRHDVLITPMMPISPFEAGHDVPPGSSYQ
                     TWPEWTRFTYPFNLTQQPAISVPIGFTAAGLPVGLQIVGPRHSDDLVLAVAKLVEEVIP
                     RTTDRPAAPRR"
     gene            complement(17752..18732)
                     /locus_tag="A4R43_RS22990"
                     /old_locus_tag="A4R43_22775"
     CDS             complement(17752..18732)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155860.1"
                     /locus_tag="A4R43_RS22990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22775"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_162788560.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.4e-48, bitscore:
                     162.3, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGTQSPVLAVLCGDQHPPDMDSIEHAAAVRYTDEAGLKKALHGA
                     DILFVYDFLSTAVPGAWEAADKLRWLHIASAGVDPVLFPGLRESDVVLTNSRGVFDDAI
                     AEYVLGVVLAFAKDFARSRQLQQERTWLHRETERISGRRALVVGTGPIGRSIARLLRAA
                     GLSVAGAGRTARESDPDFGVVHASAELTTHLGDYDYVIAVAPLTEQTKGMFDARAFAAM
                     KPGARFVNVGRGELVVTEDLIGALRDGRPAGAALDVFDTEPLPSDSPLWTMENVLISPH
                     MSGDFIGWRNTLVEVFAANFERWRTGQPLRNVVDKRLGYVPSGSN"
     misc_feature    complement(18607..18609)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(18619..18621)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18833..19573
                     /locus_tag="A4R43_RS22995"
                     /old_locus_tag="A4R43_22780"
     CDS             18833..19573
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641048.1"
                     /locus_tag="A4R43_RS22995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22780"
                     /product="Asp/Glu/hydantoin racemase"
                     /protein_id="WP_113694233.1"
                     /transl_table=11
                     /translation="MDFEMPVFDGPLAQRGIGVIAPFDLALERELWRWVPMEVSLHLAR
                     TPYEPVPVSMEMAQLVSDSKHLAAATRDVLHVEPEVVAYLCTSGSFVNGIDYERSLCKA
                     ICDAGAPDAVTTSGALAEVLHRLDLHKVSVLTPYDEDLTGKLHDFLAELDVKTVSSDHL
                     GLGGGIWKVSYRTIAERILAADHSEAEAVFVSCTNLPTFDLIEPLEAALGKPVLTANQL
                     TMWACLMRMGLPIVGPGKWLRDVS"
     gene            19619..20332
                     /locus_tag="A4R43_RS23000"
                     /old_locus_tag="A4R43_22785"
     CDS             19619..20332
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020665077.1"
                     /locus_tag="A4R43_RS23000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22785"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_113694234.1"
                     /transl_table=11
                     /translation="MTTIGFIYPDHAAEDDYPLAERLLGQRFPVEHIYGTDLHAVPELL
                     DLGSPERLKEGAGLLAKHEPDAVVWACTSGSFVYGWEGARKQADQLAEVAGVPSTSTSF
                     AFVEAAKALGVRKVAVAASYPDDVARLFVEFLGAGGVEVLSMSSAGIDTAAEVGELSPE
                     AVVELAVAHDHPEADAVLVPDTAMRTLGVLGAIEDRLGKPVLTANQVTIWEGLRQAGAP
                     VASAELGALFRDKGN"
     gene            20334..21002
                     /locus_tag="A4R43_RS23005"
                     /old_locus_tag="A4R43_22790"
     CDS             20334..21002
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670597.1"
                     /locus_tag="A4R43_RS23005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_22790"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_113694235.1"
                     /transl_table=11
                     /translation="MPLADIEPVNRESTAGIIARQLRDAIMNGALPPGTQLGETELASR
                     FQVSRGPLREAMQRLVSEGLLRSERHRGLFVIDLEPDDVYDIYVARAAIERAAALRIMR
                     GDREKAAAALDEIVREMAAAADEDDPTALSDADLRFHEVLVAESGSRRLMRMTQTLLIE
                     TRMCLSMLQQTYQRVEERVDEHNQLIDAIRAGDEETVLKLLEAHMEDAVQRLLPGTTLH
                     "
ORIGIN
        1 gggttttcgg cggcagcacg gcggttttct cgcccagcgc gcggaaggcg cgccgctgcg
       61 actcgatcgc cgcgtcgatc ccgagcagcg cgccgatctc ggcggcgtcg aagaaccgag
      121 gtgcggtcat cgggtctccc ttcggtggta cgcggcgagc agctggcgct cggcgtcgcg
      181 gaggtagcgt tccagtgcct gctcggccag gtcgaaccgg cgtcgccgga ggtggccgat
      241 gatcttctcg tgccgcgcca ggtacggctc gaagaacgcc tgtgtgcttt cggtcagcac
      301 gaagaacaaa cgcgtttcgg ccagcacctg ccgcatggtg cccgcgacgc ggtcgctgcc
      361 ggacagctcg cagagcgcct ggtgccagcg gatgctcgcg gtgccgacgg cccgccagtc
      421 ctcgtcgagc gcggcctgct tgccttcggc gagcgcggcc tccagcccgg tgagcaccag
      481 gtcctcgcga tcggctgcct cacgcacggc cgcgcactcg accatgcgcc ggatccggta
      541 caggtcctcg atgtccggcg cggtcagcac gctgacgaac acgccgcgat tcagctcccg
      601 cacggccagc cgctcgtgcg ccagcaactg gaacgcctcg cgcagcgtgt tccgcgaaac
      661 accgagcgcg ccgctgatcg cgggctcgga aagccgtgtc cccggcagga aaacgccctc
      721 ggtgatgcgc tgacgcagga tctgggccac ccgttcggcg gtgcccgccc tggcgagcgt
      781 gccgcggtcg cccgcgagca ccgccgacgg atcaccgctg gtcatcggac gcccagctcg
      841 aaatcgagcg agtaccggtt gccgggcatg gccccggccg ccttcgcgcc gtccaccggg
      901 agcacggcac cgttgacgaa ccgcgattcg tcgctggcca ggaacagcac cgccttcgcc
      961 acctcccacg cctccccgac ccgcgcggcc ggcgtgctcg cggtcagcgc gtgctgcttg
     1021 gcctcgaact cgtcgggcga cgccagcgtg ctgcgcagca tgtcggtgtc gatcgcgccg
     1081 ggattgacgg tgttgacccg gatgccgagg tgcgcgtgtg ccaccgcgag cgacttcgcc
     1141 agcccgacca gcgcgtgctt ggtggcgttg tagaccggat ccgccgggcg gcccatcatg
     1201 ccgccgttcg acgaggtgag cacgatgctg cccgccttgg cggcgatcat gtgcggcagc
     1261 accgcgcggg cggccaggaa ggcggtgcgc acgttgaccg cgaagatgtg gtcgaactcg
     1321 gcgagcgtgg tttccggcag cggcttgccg aggtggatgc cgacgttgct gaacaacacg
     1381 tcgatccggc cgtgctcgcc gagcacctgc tccacaaagg actgcacggc gctctcgtcg
     1441 gtggcgtcga cttcggtgtg cgtgaagttc tcgtgcccga ggtcttcggc cggttcgcgg
     1501 atgtcgctcg accgcacgac cgcgccctcg gcgaggaact ccttcaccgt ggccaggccg
     1561 atcccgcgtg ccccgccgaa gaccaccacg accttgttgt ccatgcgccc catgtcagtc
     1621 cctttccacg atctggtagt cggcgggcag ccggaccagc gcgtccggcc tgccggtgta
     1681 acggatttcc accccgtaga cctcgcgggc tgcttcgatc gacacgtacc cgtcgaccac
     1741 gtccgccagc acgcgttccg ggtcgcgttc gcgtgggtcg ccgtaaccac cggcgcccgg
     1801 cagcaccacg tccacctccg cttcgggcgc cagctgcacg cggcgcttgc cgggcagggc
     1861 cgtgccgtcg gcgagaccga accggccggg cgctccgtcg tgtccacagt ggacacccgt
     1921 cgccggtgcg gtggtccggt ccacgtttcc gttgacgctc caggaaatgt tcccgcgggc
     1981 caccaccgtg gtggactggc cgagaccacc gcggtaggtg cccgcgccac cggagtcggt
     2041 gcgcagcacc cggcgggtct ggaccagtgg cgccatggtc tcgatcacct cggtcggcgt
     2101 ggcgcgcagg ccgctgggga agcccgtggt gttcagcccg tccttggtgg tcctggcccc
     2161 gatgccgccg gtctggaaga cgttcagcat gaactcgcga ccgtccggtt cggaccgtcc
     2221 acgccagatg gtcatccaca gcgcgtccgc gctgtgcgcc atccgcccgt ccagcgcgcc
     2281 gatcagcagc gacggcagga agtggccgat caggtgccgc gaggcgaccg gcgcgggcgg
     2341 caggcagttc agcaccgaac cggcgggcgc ggtcacgtgc accggccgga acgagcccgc
     2401 gttgtgcggc acctccggcg cgatcgccgc cttcaccgcg aaggaggcgt acgccctggt
     2461 gtagttgagc accacgttga tgccgtgcct gctctgcggc gacgaaccgg cgaagtcgat
     2521 gtcgatgtcc tcaccgcgca cggtcagcgc gaccttgagc cgtacctcct cgtcaccgaa
     2581 gccgtcggtg cgcagctcac tgcggaaggt gccgtccggc agcgcggcga tggcgtcgcg
     2641 cagcgcccgt tcggaccggt tcatgatctc cgcggcgatc tcgtcgatcg agtccaggcc
     2701 gtactcctcc gccaggcgca ccaggctcgc cgccccgacc tcgttgcccg cgacctgcgc
     2761 gtacaggtcg ccgatggttt cctccggcgt gcgcacgttg gcgcggatga tcgcctccag
     2821 ctcggcgttc acctcgccgg cgcggaggaa cttcatgatc ggcagccgga ggccctcttc
     2881 gaacacctcg ttcgcctcgg ccgaaaccag ccgaccgccg atgtccggcg cgtggcagca
     2941 cgaagcaaac caggcgatca cccggccgcg gtggaacacc ggggtggcca cggtgatgtc
     3001 gttgatctgg cccgccgtct gccacgggtc gttggtgagc agcacgtcgc ccggttcgag
     3061 ccgctccggc gggaaggcgg cgacgaagtg gtgcatcccg gtggccatcg cgttgatgtg
     3121 accgggcgtg ccgccgaccg actgcccgat catctcgccg cgggagtcga acaccgcgca
     3181 cgccaggtcg agcgattcac ggaccaccgc cgaaaaggcc gtgttgacca gtgcgttctg
     3241 ctgctcggcg aggatcgagt gcagccggtt gccgatcacg ccgacgagga tcgggtccac
     3301 gctcacgggg tcaccaccag gctcgcgtcg gcgcgcacgg tacagctcgc gcctggcggt
     3361 atgaccaaag tggactcgcg ttcctcgatg atcgccgggc cgtcgatccg gtcgccggac
     3421 ttcagcaggt agcggtcgta cacggcggtg tcgacaaatc cacccgggaa gtacgcctgc
     3481 ctgctgccct tgcgggcttc gccctcgccc ggttcgacgt tcagccggag gttcacccgc
     3541 ggcaccggcc ccgacgagac cacccgccag ttgagcacct cgacgccgac gtccggcccg
     3601 gtgcgccggt acagctcgcg gtaggtctcg gtgaagtcgt tcaccagcga ggcgggccac
     3661 tccccccggc gcaccggcac ccggatctcg tacccctggc cctggtaccg catctcggcg
     3721 atccggctgt gcgtcactat gtccactccg gacgctttca gcagttcctc gccctcgcgc
     3781 tccatttcgg cgaacagggc gtccacttcg gaccagctca gctcgtccac cccggcgcgc
     3841 gaggtccgca cgaagtcgaa ggccagtggc gcggtgagga aaccgaccgc gctcatcacg
     3901 cccgcggccg gtggggccac cacctggcgc gcgcccagcg cccgcgcgac acccacgccg
     3961 tgcaccggcc cggcaccgcc gaaggtgaac atcggcagcc gcgccgggtc cttgccgcgt
     4021 tccaccgcgt gcgcccgcgc ggcgttggcc atgtcctcgt tgacgtgcgc gtgaatgccg
     4081 taggccgcct cggccaggcc gacgcccagc ggtccggcga tcttctcgcg gatgaccgcg
     4141 cgagccgcct ccaggtcgag cgccatctcc ccgccgagga agtaacccgg gtccaggtaa
     4201 ccgaggacca ggtcggcgtc ggtgaccgtg ggctcggtgc caccacggcc gtaacagacc
     4261 ggtcccggct cggaacccgc cgaatcgggg ccgacggtga gcagaccgag cgcgttgatg
     4321 cgggcgatcg agccgccgcc gacgccgatc tcgatcatgt cggtcaccgg caccttcacc
     4381 ggcagcccgg agcccggcag cagccggtac accctgtcca cttcgaactc gtgcgtgacc
     4441 agcggcgcgc caccggagat catgcacagc ttcgccgtgg tgccgcccat gtcgaaggcg
     4501 agcaggtccg cctcaccggc ggcggccccg aacgccgagg ccgccagcgc cccgccggcc
     4561 gggccggatt cgaggatgcg gatggggtac cgcgcggccg tgtccactgt ggctattccg
     4621 ccgttggaca gcatgatgtg cggtgccggg ccgatgccgg cgcggtgcac ccgctgctcc
     4681 aggtcacgca ggtagcgctc ggtcaggtcc tgcacgtaca cgttcgcggc ggtggtcgag
     4741 gcgcgctcga actcgcggat ctcgggcacc acctccgacg acagcgcgac tcgcagcccc
     4801 ggcgccacct cggccagcac gtcccgcgcg cggcgttcgt gctcgggatt ggtgaaggag
     4861 tgcaggaagc agatggccac cgcttcgata ccgcgctcgg ccagctcggt gccgagccgc
     4921 gcgacgtggt cctcgtcgag cggggtgcgc acgctgccgt cggccaggat ccgttccggc
     4981 acgtcgaacc ggaggtgccg cggcaccagc ggctcgggca gttcgatttc caggtcgtac
     5041 agctcgtagc ggtgttcgcg gcgcatctcc agcacgtcgc ggaacccctc ggtggccagc
     5101 agcgccagct tcgcgccctt gcgctcgatc agcgcgttgg tgaccagcgt ggtgccgtgc
     5161 accagtttgt ccacttggga cggctgggtc agcgtcgcgg tcagcagctc accgaccgcg
     5221 cgggcgggtt cgtcgtgggt ggtcagcgtt ttgccgatgg ccaccacccc ggagtcgtcc
     5281 agcacgcaca gatcggtgaa cgtgccaccg atgtccacgc caacccgcag tgccatcacc
     5341 gctccttccg gtaccagcgt ggtgaggtgt tcagcggggg tcgcatggcc gcctcgacca
     5401 ccattaggtt cggttcgtcg gcctggatga acgcgcccag cttccgccgg aaggcgcggc
     5461 cgaagccctt gacccgctcg gcgcggatcc cgaacgactt gcccagcgcg acgaagtcgg
     5521 gaccgaccag gtccaccccg cggtgcggca ggccgctgtg cgtctggtcg taccgcagca
     5581 tgccgtaccc gccgtcctcc accacgacca cggtgaccgg caggttctcc tgcgcggcgg
     5641 tggccagatc accgcagccg taaaggaaac cgccgtcgcc ggtgatgcac accgcgcggc
     5701 ccgcgcccgc cgccgcactg ccgatcgcgg ccgggaagcc gaagccgagc gtgccccagc
     5761 ccatcgggta ggccagcttg cgtggcgccg gaatgcggtg gaaaccgccg atccagtacc
     5821 ccgcgatgca catgtccgag accaggatcg tgtcctccgg cagcacttcc tccagtgtgc
     5881 cgaggaagtc ggcggcctgc ggctcgtcct cgcggatgcg gcggcgcacg gccgcgctca
     5941 tccgccgcag gcgcgcggtg agcttgtcca ggccttcctt gggcggcagc tcgccgagca
     6001 gcgcggtgac caccgtgcgg gcgtccccga ccaggttcag gtccggctgg tagttcttcg
     6061 ccgcgtccgc cgcgtcgacg ttgaccgtga ccagcgtcgg cggttgcggc atcagccagt
     6121 tctgcgtcat cagcccgtcg aagtcggtgc cgacgccgag caccaggtcg gcctcgtccc
     6181 agagcgcgcc gacctccggg gcgtgcaccg aattcggggc caggcaagga tgttcgggcg
     6241 ggagcaggcc acgcgcggcg aaggtggtga gcaccggcgc ggcgagtttc tccgccagct
     6301 caccgatgac cgccccggca cccgcgcgca acgcgccacc accggcccag atcagcggcc
     6361 gctcggcgcg ctcgaacaac tcccgcgcgc gccccaggtc gagcggctcg gcgacgggcg
     6421 tgcggtccgg cgtatcggga acgcgctggg cggtggcgga caggaagtcg gtcggaatgc
     6481 ccaggtagac cgggccgctc tgcggccgca gcgccagccg ggccgcggtg agcgcggtgc
     6541 cggcgatctc ccccgtgccg ccggcggtgt actgcgcctt ggtcagcggc gcgaacaacg
     6601 cggcctggtc actggtctcg tgcagcaccc cgcgcaccat gccgggacgg cgcagcgtgg
     6661 acgggatgtc ggtggcgacg accagcaccg gcgagccgga ggcctgcgcc tcgccgaccg
     6721 cggccagcgt gttcgccgcg ccgggcccgg tggtcacgat cgccacgccg agcttgccgg
     6781 tggcgcgggc gtacccgtcg gcggcgtacg cggcggtctg ctcgtggcgg acgccgatca
     6841 gctggatccc ggtgtccgcc agtgcttccc agatcggcag gttgtgcacc cccggcaggc
     6901 cgaaggcgac ctgaacgccc agttccccca gtgcgtcggc gagccggtcg gccccggact
     6961 tcggcttggc atggctgact accggcaccg gcacagccta cgagatcgtt caacgattga
     7021 acaccccagc tagacgatgt tgtgctcccc gccgccggtt ccgccgccgt cgaagcggcg
     7081 cacgtccagc gtggagacgt cgatcgacgg cgcccgtccc aggtagaggt cccgcatcac
     7141 ctcgcccacc gccgggccca tctggaaccc gtggccggaa aacccggtgg cgtacaggaa
     7201 tcgcgacacc ccggccgcct cgccgaccac ctggttccgg tccggcgtca tctcgtacaa
     7261 ccccgcccag gccgcgcgga tgcccgcgtc cagcaccgac ggcgcccgcc gctcgaccag
     7321 ttcggccagc gccggcagcc actcccccgg ctcgtaccgc gtgtcgaagt ccgcctccgg
     7381 cgtgccgggg aacgacaagg ccagcccgtc gccctcgggg tggaggtaga acgccgaggg
     7441 catttccacc gtcagcggca ccgaatccgg ccgccccggc acgggaccgg tgaacaccac
     7501 ctgccgtcgt tccggccgga ccggcagcgg gcagcccgcc agcgcaccga tgcgcgccga
     7561 ccaggccccg gccgcacaca gcaccacccc ggtccggacc actcccgcgg tggtccggac
     7621 cgcgcggatc cggtcgccgt cgcgctcgat cccgtccacc tccacgccgg tgcacaacgt
     7681 cgcgccgagc gcacgcgccg cccgcgcgta cccctgcacc accgcgtccg gcgtcgcgcg
     7741 cccgtcaccc ggcgaccaca ccgccgcgtg cacaccgtcg accgagatca gcgggttgtg
     7801 ctgcttcgcc tccgccggtt cgaccacgcg gctcgccacg ccgaacgagt tctgcaacgc
     7861 cacgcccgct tcgaaccgcg gcaggtcggc cgggtcggtg atcaggtaga ggtaaccgtc
     7921 gcgccggaag tcgatctcct ggccgaaccg cgcggggaac cgctcgaatt cggccagccc
     7981 gcgcaggccc agctcgatgt tgacccggct ggtgaacgag gaccgcaccc cgcccgccgc
     8041 cttcgccgtc gagccggcgc ccagcgcgcc gcgttccagc agcagcacgt ccaccccggc
     8101 ctcggccagg tggaacgcgc agctcgtccc gatcaccccg ccgccgacga ccaccacgcc
     8161 ggcctcttcg ggcagcttcg ccatgtacgc agggtagatc ccttcgttga gggctttcct
     8221 cacggcgaac cgtgcgtaga ctcggccctc cggtggaacc caccccgtgg gtgctcgacg
     8281 aaagggggcc ggaaatgccg ctgatgccca tcaccgactc gatgttcctg atggtggaat
     8341 cccgcgagca cccgatgcac gtcggcggcc tccagctgtt ccgcaaaccc gaagacgccg
     8401 ggccggacta cctcagcgaa atccggcgca ggctgctcga ccgctccgag gtccgccgcg
     8461 ccttccgccg ccgtcccgcc cgcccggtga acaccatggg ttacgccgcc tgggccgagg
     8521 acgtcgaact cgaactcgac taccacttcc ggcattccgc gctgccgcag ccgggccgca
     8581 tccgcgagct gctcgaactg accggccgct ggcacagcac gctgctcgac cggcaccgtc
     8641 cactgtggga agtccacctg gtggagggct tgcgggacga ccggttcgcg atgtacagca
     8701 aggtgcacca cgcgttgatg gacggggttt ccgcgctccg ccagatgcag gcgacgctca
     8761 gcgagagccc ggacgagcgt gactctccgc cgccgtgggg cgggccggca gcgacaaagg
     8821 gcgtgcgacg cagccgccgc gacccggtct cgctgctcac cggcgcgcgc cagtcgctca
     8881 gccagctggc gaagctgccg ggggccgcgg tgaaggtggc caccgaagcc ttccgcgagc
     8941 acagcctgac cctgccgacg caggccccga agaccatgct caacgtgccg atcggtggtg
     9001 cgcggcggtt cgccgcgcag tcgtggtcgc tcgaccgcgt gcgccaggtg gccaccgcgg
     9061 ccggtgtctc ccgcaacgac gtggtgctgg cgatgtgctc cggcgccctg cgtgactacc
     9121 tcatcgagca gcgggcgctg ccggacaccg cgatggtcgc gatggtgccg gtgtccatgc
     9181 gcaaaccggt cgaaaccggc gccagctcgg gcaacgcggt cggcgcgctg ctgtgcaacc
     9241 tggccaccga ccgcagcgat ccggccgagc ggctcaagct gatccaccag tccatgcgga
     9301 acgccaagcg gatcttcaaa gacctcaccc cggtgcaggc gctcatcctg tccggcatca
     9361 acgtggcccc gctgggcgcg tccaccatcc ccggcttcgt caacaacacg cgcccgccgt
     9421 tcaacctggt gatctcgaac gtgcccggcc cgcgcaagac catgtactgg aacggcgcgc
     9481 agctcgacgg ggtctacccg gcctcggtac tgctcgacgg gcaggccctg aacatcacgc
     9541 tgaccagcaa cggcgacaac ctcgacttcg gcatcaccgg ctgccgccgc agcgtgccgc
     9601 acctgcagcg catcctcacc cacctggaca ccgcgctggc cgaactggag agcgcggtcg
     9661 cctgagtcgt cggatcattt cttctcaccc tgggtgagga cagcgcggct ttactactcc
     9721 atcagcggga cgatggcttg gggcaagtca gaaattagcc gacttcccta gatttccgtc
     9781 gggcggcgct tctagggtcg tcttgcccgg tcgtcagtga tccgaggagt cagcatgatc
     9841 gaaaccgcta ccgaggtctg gaccactccg gacttcgtgg agtacgagac cccgatggaa
     9901 gtcacggcct acgcggcccg gatggaataa gcacgggcgg gcgggggccc gcgcggcccc
     9961 cgtccggttc gccagcgcct cgacgaccag gaggtccgcc atgagcgcgc cgctcagcca
    10021 cgaagagttc gccgccgccc tgcgtggact gtcccaccgg tactggggca cccacccgtt
    10081 ccaccaccgg atgcacgccg gtgagctgtc cgagcgcgaa ctgcggatct gggccgcgaa
    10141 ccgctggtac taccagcgca tgatcccgca gaaggacgcg gcgatcatca gcaactgccc
    10201 gctgcccgag gtacgcaggc agtggctccc ccggctggtc taccacgacg gcgccaccgc
    10261 gggtgagggc ggtatcgagc gctggctgcg gttgtgcgag gcggtcggtc tcagccgcga
    10321 ggaagtgctg gacgagcggc acgtcgcgcc cggtgtgcga ttcgccgtgg acgcctatgt
    10381 cactttcgcc aggacaaaac cgtgggtgga agcggtggcc tccggcctga ccgagatgtt
    10441 ctccggtcat ctgatgaaac gccgcgtggc cgacatgctg gcgaactacg cctggatcaa
    10501 ccgcaccgac ctggcctact tcaccaaccg catcgacgcc gtctccggcg agggacaggc
    10561 cactgtggac ctggtgctgc gccactgcga gacccgcgcc cagcaggagg ccgcgatcgc
    10621 cgcgctctcc ttcaagtgcg acgtgctgtg gtccatcttg gacgccatcg aacgcgccgc
    10681 ggccaaggag tgagcgtgaa accccgtctg cgccgcggtg tccggctcac ctacgacaag
    10741 gttcgcgaga cgcacgtgct gctctacccg gaaggtgtgc tggtgccgaa caaaaccgcc
    10801 gccgccgtgc tcgagctgtg cgacggcgaa agcacggtcg ccgacatcac cgcggcgctc
    10861 ggcaagcact accgcggggt gcaggaggcg gacgtgaacg gtgtgctgtc acgcctggtg
    10921 gaacggcggg tggtcgaatg gctgtgaagc ccgcggagcc accactgggc atgctggccg
    10981 agctgaccca ccgctgcccg ctgcactgct cgtactgctc caacccgatc gagctggtca
    11041 ccagggagcg cgaactcgac accggccagt ggctttccgt gctgtcacag gcacgcgagc
    11101 tgggcgtgct gcaggtgcac ctgtccggcg gtgagccgct ggcgcggccc gacctgccgg
    11161 aactcgtctc gcacgccagc gaactcggct gctacgtcaa cctggtgacc agcggtctcg
    11221 ggctgaccga aaagcggctc gacgacctcg ccgaccgcgg cctggcccac atccagctgt
    11281 ccgtgcaggg cgcggacgcc gagcgcgcgg accggctcgc gggcaccagg gcacacgagc
    11341 acaagctcac cgccgccgcg ctgatcaagc gcgccgggct gccgctgagc gtgaacgtgg
    11401 tgctgcacaa gcaaaaccac gaccagctcg ccgggatcat cgcactcgcc gaacgcatgg
    11461 gcgccgaccg gctcgaactg gcgaacacgc agtactacgg ctgggcgctg aagaaccgga
    11521 ccgccttgat gccgacgcgt gagcaactcg cggccgccga accggtcgtg cgcgccgcca
    11581 ccgagcgcct gcgtggcgcg atggaggtca tctacgtggt cgcggactac tacgagccgt
    11641 acccgaaacc gtgcatgtac ggctggggcg cgcggcagct gaccgtggcg cccgacggtg
    11701 acgtgctgcc gtgcccggcg gcgaccgcga tcaccacgct cgaactggac aacgtcaccc
    11761 ggaaaccgtt gcacgacatc tggtaccgct cgagttcgtt caacgcctac cgcggtgagg
    11821 actggatgag cgagacctgc cgctcgtgcg accggcgcgg cgccgaccac ggcggctgcc
    11881 gctgccaggc cttcctgctg accggggacg cggcggccac cgatccggtc tgctcgcgct
    11941 cgccggaccg cgagctggtc gacctcatcc tggccgcgcc accaccggcg gtcgagccgg
    12001 agctggtcat gcggcgggtg gcacgatgaa ggtcctgctg ctcggcaccg ccgccggagg
    12061 cggtttcccg caatggaact gcgcatgctc gttgtgcact tcggacgctc cacatcggac
    12121 gcaggactgc gtggcgatca gcgcggacgg gcgcggctgg tacctgctca acgcgtcgcc
    12181 ggacatccgc gcgcaaatcc tcggctcgcc cgtgttgcga gccgggccag ggccacgcga
    12241 gacaccgttg cgtggtgcgc tgatcaccga cgccgagctg gaccacacgc tcgggctggt
    12301 catgctgcgc gaagcgccgt cgttcggcgt ctggggaccg gacgccgcgc tgcacgcgat
    12361 gcgcggcgcg ttacccgttg gccgctacgg ggattggcgg ttttccccgg tggcaccgga
    12421 aatcggcggc ctgcgggtgt cggcgctgcc ggtcagcgac aagaagccga agtacgcgcg
    12481 tgattccact atggacggcc cttgggtggt cgcctaccgg atcgaggacc cggccaccgg
    12541 tggtgtgttc gtctacgcgc cctgcctggc ggcctggccg cccggcttcg acgagttcac
    12601 cgacggtgcc gactacgtgc tgctcgacgg caccttctac ggcgccgacg agatgtccgg
    12661 ggcgacccgc gccggagtcg gcacccaggc gcagcgcgcc atggggcacg taccgatctc
    12721 cggcgcggac ggcagcctcg cccgcatccg cgaccgcccg ggaccacgct gggcctacac
    12781 gcacctcaac aacacgaatc ccgcgctcgc cccggattcc ccggaacaca aggaaatcct
    12841 ggccgccggc gccgaactgc cgctcgacgg cacactgctg gacctctagg cgacgccctc
    12901 cggattggcg ccttcgacct gcacggcgcc ggcggtgagg cgctcgatct cggccaggtc
    12961 cgcggcgctc aggtcgacgt ccgcggcggc caggctctcg gagatgttct tcggcttgcg
    13021 ggcaccgacg atcgccacgt gcacaccggg ttgcgcgagc acccaggcga tcgccagctg
    13081 gctgaccgtg atgttcttgg tggccgcgaa ctccttgagc cggtccacca cttccaggtt
    13141 gcgccgcagg ttctcgccct ggaacgcgga cgacttggaa cgccagtcgt cgctgtcgaa
    13201 ggtgctgtcc ggcgtgagcg caccggtgag caggccgctg ccgagcgcgc tgtaggcgag
    13261 cacgccgatg ttgtgctcgc gcgcgtacgg catcggatcc tgctcgatcg cgcggcggaa
    13321 caggtggtac ggcggctgga gcgtctcgac cggccgcgtc gcgtcgaagg cggccagctg
    13381 ccgagtgtcg taattggaca ctccggcgtg ccggatcttg ccctcgtcca ccagttcctg
    13441 gagcgccgac gcggtttcct ccgcgggggt gtcggcatcg ggccagtgca cctggtacag
    13501 gtcgatgtgg tccagcccga ggtgtcgcag gctttcctca acgccgctgc gcagcgactt
    13561 ccgtccggcg tcacgcgagc gctgctcgcc cgggtagatc ccgcccttgg tggcgatcac
    13621 cagactgtcg cggtcacggg tcagctcctc gcgcaacgcc ttgcccagca aggcttccga
    13681 cttgccgaag ccgtaaccct gtgcggtgtc gaagaagttg acgccgagtt cgcgcgcgtg
    13741 ccggatggcc tcgatcgcgg tgtcctcgtc gaacgcgccc cagtccccac cgagctgcca
    13801 ggtcccgaac gcgatccggg aaacctccag cccgctcctg cccaaagtcg tcgtacgcat
    13861 gcgcccagcg aaacacaggc ggggcgcacc cgcatgccgc aacccccaaa gaagtgtttg
    13921 acagctggcg gtcgccgccc gacactcggt cgcatgccgg agaaggcccc gctgctggag
    13981 ctgcgcgtgc tcgcccaccc gctgcgcctg cgcatcctgt cgctgctcac cgggaccgcg
    14041 atgagcgccg ccgaagccgc tcgtgaactg aacgagacgc aggccaacgt gagctaccac
    14101 ctgcggcggc tgcacgaggc ggggctgctc gaagtcgccg aggaggtccg catccacggc
    14161 gggctggcga agcgctaccg gcacgtcccc ggccgcggac ccgcctggga ccacggtgat
    14221 cgcgagggcg agcagctgtt cgccgaggcg ctggccggcg agttgcggcg gcgcaccgag
    14281 caccgcttgc cgtccggccg atccgccatc acggacgccg aagtctggct gagccccgac
    14341 gactgggcac gcgccgtgcg attggcgcac gaactcggcg aactgctgca cgacgccgcc
    14401 cgcccaccac gcacgccgga aacccaacgg gtcagcgcca ccatcgccct gttcgagatg
    14461 accgcgtcat gagcctgcgc gaaccgttgc ggcaccgcag tttccgctgg ctgctggccg
    14521 ggcggaccgg cgccgaactg gccaacgcga tcgcaccggt ggcgctggcg ttcgcggtgc
    14581 tggacctgac cggctcggtg gtcgacctcg gcctggtggt cggcgtgcgg tcgctggcga
    14641 acgtgatcct gctgctgttc ggcggggtgc tggccgaccg gctgccgcgg gcggtgatcc
    14701 tgcagggcac cggggtggcc gccgcgctca cccagggcct gatcgcggcg agcgtgctcg
    14761 gcggtttcgc gtcgatcccg ctgttgctgg ggctgagcgc gctcaacggc gcggtgagcg
    14821 cgatgtcact gccggccgcg gcttcactga ccccgcagac cgtgcccgcg acgctgctca
    14881 cgccggcgaa cgcgctggcg cgcatgggcg cgaacaccgg gcgcatcatc ggcgccgcac
    14941 tgggcggggt gctggcggcc ggggtcggtg cggggtgggc catcgcggtg aacgcggtgg
    15001 tgttcctgtt gtcggcggcg ggttatcgcg gggtccggat cgtgcggcgg gtgcgcgagg
    15061 agcggtcgaa cccgctgaag gacctggccg aaggctggcg ggagttcacc gcgcggtcgt
    15121 gggtgtgggt ggtggtggcg cagttcaccg tggtcaacgc ggtgatcatg gggagccacg
    15181 cggtgctcgg cccgaaggtc gccgacgaca cggtggggcg cgcgggatgg ggttttgtgc
    15241 tggcggcgga aacactgggg gcgttcgtcg gcggggtgct ggccgcgagg tggcaaccgc
    15301 ggcgggcgct gctgatcggg gtggcggtga tcagcgtcga ggcggtgccg ctggtggtgc
    15361 tggcggagct gccgtcgctg gtgcccttgc tggcggcgat gttcctggcg gggatcgcga
    15421 tcgagcagtt cgtggtggct tgggatgttt ccctgcagga gaacattccg gaggacaaac
    15481 tggcgcgggt ctactcgtac gacatgctgg gctcgttcat cgccatgccg gtcggcgaaa
    15541 tcgccgcggg gccgctggcc gcgcgcttcg gcgcggacgt gactttgctg gccggagcac
    15601 tgctcgtgtt ggtgagcacc gctctcgctt tgtgcagtgc gcagatccga tcgctgacga
    15661 gaaaggccgc gcaacccgcc tccgtcaccg gcccgatccc ttcgaccgac cacaccccga
    15721 ccccgtagcc actctccgct catcccgggg gcggactagg cggtgtcacg aatgtggctt
    15781 tcgagacgtt tggcgtcccg aaagccacat tcgtgacact ggcgccgccc tggcgctgct
    15841 ggctcgcgct cgtcggcgga gactttcgcg aagcccgatc tcgtatctga cgcgtgatcc
    15901 gaaaagagag cgatgctcac cgaagtgagc accgctctcg aagccgccaa gcgcccactc
    15961 cgccagagcc tccgcgaaag cctcgccgcc aatgggccgc cacaaagact caccgcgaaa
    16021 gacttgccgc ggaagggacg gcagaaggcc gccgtgcaag gcccgctgta gaaggcctgc
    16081 cgcgaaggcc gccgcagagg cccgccgcga aaagggtcgc cacagaaggc ccgccgcggg
    16141 aggggcgccg cagaaggtcc ccgcggaagg cccgctgcga aagggcgccg caaaagactc
    16201 agcgcgaaag actcgccgcg aaaggggcgc cgtggaaggt ccgccgcggg aggggcaccg
    16261 cgggaggctc gccgcgaaaa ggcccgaagg tcagccacca aaggggcacc cgccgagccc
    16321 tacagcggaa acgtcaccgg cgcggcgccg ctggccgatc cgtagtccgc ggaatgacct
    16381 cttccaccag cttcgcgacc gccagtacca aatcgtccga atgccgcggc ccgacgatct
    16441 gcaaccccac cggcaaaccc gccgccgtaa acccgatcgg cacgctgatc gccggctgct
    16501 gcgtcaggtt gaacgggtac gtgaaccgcg tccactccgg ccaggtctgg tacgaactcc
    16561 ccggcggcac atcgtgcccc gcctcgaacg gcgagatcgg catcatcggc gtgatcagca
    16621 catcgtgccg caggtggaac tcgcccatgt gaatgcccag cgcggcccgc accgcgctcg
    16681 cctccaggta gtcgcccgcg gagaacgtgt gcccgtgctc ccagacccgc cgcagcccct
    16741 ggtcgatcag ctccgccgac ccctcgggga acgtgtccag ccacttcgcc gcccccgtcg
    16801 accacagcac gtcgaacgcg tccagcgggt ccgcgaaccc cgggtccgtc tcctcgatcc
    16861 gcaaccccgc ctcgttcacc gcggccaccg ccgccagggt gatccgcgcg atctccgggt
    16921 ccacgtccac atacccgagg ttcgccgagt acgccgcgtt caccccgcgc acatcccgcc
    16981 gcaccgcctc gcggtacgaa ctcaccggcg gcgccagcgc cgacggatcg cggtgatccg
    17041 gcaacgccag cacatcgagc agcaacgcca cgtcatcgac cgagcgcgcc atcggaccgg
    17101 cgtgccccag cggcccgaac gggctcgccg gatacagggg aatccgcccg tgcgtcggct
    17161 tgaagccgac gatgccgcag aacgacgccg gaatccgcac cgagccaccg ccgtcggtgc
    17221 ccaccgacag ctcacccatg cccgccgcga ccgccgccgc gctgccgccg ctcgaaccgc
    17281 ccgcggtgag cgccggatcc cacgggttgc gggtgatgcc gttcaacgtg ttgtcggtga
    17341 cggccttcca gcccagttcg ggcgtggtcg tcttgccgag caggaccagc ccgtgctcgc
    17401 gcagccgcgc ggtgaccggg ctgtcgacct cccacgggcc ggccgggtcg atgcaccgcg
    17461 aaccgcgctg cgtcggccag ccctgggtga ggaacatgtc cttgatcgag gtcggcaccc
    17521 cgtccagcca gccgatcgga ttgccctcgc gccaccgctg ctcggccagt tttgcctgtt
    17581 ccagcgcgga atcggcgtcg acaaggcagt acgcgttgag ctcaccgtcc cgctcggcga
    17641 tcgcatcgag ggaggcctgg gtcgcctcca ccggcgacag ctccccggac ccgtaggccg
    17701 cgacgagctc actggccgtc agcagggtcc ccgactcgtt catggtcctc ctcagttgct
    17761 gcctgacggc acgtagccca aacgcttgtc cacgacatta cgaagcggct gcccggtgcg
    17821 ccaccgctcg aagttggcgg cgaacacctc gaccagcgtg ttgcgccagc cgatgaagtc
    17881 cccggacatg tgcggggaga tcaacacgtt ctccatggtc cacagtggac tgtccgaggg
    17941 cagcggctcg gtgtcgaaca cgtccagcgc ggccccggcc ggacggccgt cgcgcagcgc
    18001 gccgatcagg tcctcggtga ccaccagctc gccccgcccc acgttgacga accgcgcgcc
    18061 gggcttcatc gcggcgaagg cccgcgcgtc gaacatgccc ttggtctgct cggtcagcgg
    18121 cgccaccgcg atcacgtagt cgtagtcgcc gaggtgcgtg gtcagttccg cggacgcgtg
    18181 caccacgccg aagtccggat cggactcgcg ggccgtgcgc ccggcaccgg ccacggacag
    18241 cccggcggca cgcagcaggc gggcgatcga ccggccgatc ggcccggtgc cgaccaccag
    18301 cgcgcgcctg ccggagatcc gctcggtctc gcggtgcagc caggtccgct cctgctggag
    18361 ctgccgcgac cgcgcgaagt ccttggcgaa ggcgagcacc acacccagca cgtactcggc
    18421 gatggcgtcg tcgaacacgc ctcgcgagtt cgtcagcacc acgtcgctct cgcgcaggcc
    18481 ggggaacagc acgggatcca cgccggcgct cgcgatgtgc agccagcgca gcttgtccgc
    18541 ggcctcccac gcgccgggca cggcggtgga caggaagtcg tagacgaaga ggatgtcagc
    18601 gccgtgtaac gccttcttta aacccgcctc gtcggtgtaa cgcaccgcgg ccgcgtgctc
    18661 gatgctgtcc atgtccgggg ggtgctggtc gccgcacagc accgccaaca ccggggattg
    18721 ggtgccgatc accgttgaca cggtatgagc cggtcgtatg attgtcaaca atccgaggag
    18781 ccaccccgga ggctctctgc attcctgaag acgtcaccgc ggaggcttgg ccttggattt
    18841 cgaaatgccc gtgttcgacg gcccgctcgc gcagcggggc atcggggtga tcgccccgtt
    18901 cgacctcgcg ctggagcgcg agctctggcg ctgggtgccg atggaggtct ccctccacct
    18961 ggcccgcacg ccgtacgaac ccgtgccggt gagcatggag atggcgcaac tagtcagcga
    19021 cagcaagcac ctcgcggccg ccacgcgtga cgtgcttcac gtggaaccag aggtggtcgc
    19081 ctacctctgc acgtccggca gcttcgtcaa cggcatcgac tacgagcgct cgctgtgcaa
    19141 ggcgatctgc gacgccgggg cgccggacgc ggtcaccacc tccggcgcgc tcgccgaggt
    19201 gctgcaccgc ctggacctgc acaaagtctc cgtgctgacg ccgtacgacg aggacctgac
    19261 cggcaagctg cacgacttcc tggccgaact ggacgtgaaa acggtgtcca gtgaccacct
    19321 cggcctcggc ggcggcattt ggaaggtgag ctaccggacc atcgccgagc gcatcctcgc
    19381 cgccgaccac tccgaggccg aagcggtgtt cgtcagctgc acgaacctgc ccaccttcga
    19441 cctgatcgag ccgctggagg cggcgctcgg caaaccggtg ctgaccgcga accagctcac
    19501 catgtgggcc tgcctgatgc ggatgggcct gccgatcgtc ggccccggga agtggttgcg
    19561 tgacgtttcg tagcgtggtt cgttaggatt gtcgacaatc tgcaggaggt gctcgagctt
    19621 gaccacgatc ggcttcatct acccggacca cgcggccgag gacgactacc cgctggccga
    19681 gcgccttctc ggacagcggt tcccggtcga gcacatctac ggcacggacc tccacgccgt
    19741 gccggagctg ctcgatctcg gcagcccgga gcgcctgaag gaaggcgccg gactgctggc
    19801 caagcacgag ccggacgccg tggtgtgggc gtgcacgagc ggcagcttcg tctacggctg
    19861 ggagggcgcg cgcaagcagg ccgaccagct cgccgaggtc gccggggtgc cgtccaccag
    19921 cacttccttc gcgttcgtcg aagcggccaa ggcgctcggg gtgcggaagg tggccgtcgc
    19981 cgccagctat cccgacgacg tcgcgcggct gttcgtcgag ttcctcggcg cgggcggggt
    20041 cgaggtgctc agcatgtcca gcgcgggcat cgacaccgcg gccgaggtcg gcgagctgag
    20101 cccggaggcg gtggtcgagc tggcggtcgc gcacgaccac ccggaggccg acgccgtgct
    20161 cgtgccggac accgcgatgc gcacgctcgg cgtgctcggc gccatcgagg accggctcgg
    20221 aaagccggtt ctcaccgcga accaggtgac catctgggaa ggtcttcgcc aggccggcgc
    20281 cccggtggcg tccgccgagc tgggagctct gttccgggac aagggaaact gacatgccgc
    20341 tggccgacat cgaaccggtg aaccgggagt ccaccgcggg catcatcgcg cggcagctcc
    20401 gcgacgcgat catgaacggc gcgctgccgc ccggcacgca gctgggcgag acggagctgg
    20461 cctcgcggtt ccaggtttcg cgtggcccgc tgcgcgaggc gatgcagcgg ctggtctccg
    20521 aggggctgct gcgcagcgaa cggcaccgcg ggctgttcgt gatcgatctc gagccggacg
    20581 acgtgtacga catctacgtc gcgcgggcgg cgatcgagcg ggcggcggcg ctgcggatca
    20641 tgcgcggtga ccgggaaaag gccgccgccg cgctcgacga gatcgtgcgt gaaatggccg
    20701 cggccgccga cgaggacgac ccgaccgcgc tgtccgacgc cgatctgcgc ttccacgagg
    20761 tgctggtcgc cgaatccggc agccgccggc tgatgcggat gacgcagacg ctgctgatcg
    20821 agacccgcat gtgcctttcg atgctgcagc agacctacca gcgggtcgag gaacgcgtgg
    20881 acgagcacaa ccagctgatc gacgccatcc gcgccggtga cgaggaaacc gtgctgaagc
    20941 tgctggaagc ccacatggag gacgccgtgc agcggctgct gccgggcacc acgctgcact
    21001 gaaatccctg acgaaagtca gggccgggcg gcgacggtcg gccgctgtgc cgcccccgtc
    21061 ccggttcgta gcgtcacccg gtgaccaaaa cgaagctgct ctggtggtcc ggcgtcgccc
    21121 tgctcgcgct gaccgtgcac accaactggg ccagtccgct cgcggcctgg ctgttcgcca
    21181 tcccactgct cctgttcacc ttcgccgcgc gccgcgggct gctcaaggtg ctcggcgcgc
    21241 tcgccatcgg cacgctcgtc tggctggcgg cgaccacgtt gttgttcgtg cccgccgcgc
    21301 tgctcgcctt cgccgtgctc acgttgctgc agtggctggc cttcgtcgcg caccggctgc
    21361 tcacgccgcg cctgcccggt ttcctgggca cgctggtctt cccggtcacg ctcgccggtg
    21421 ccgagtacct gttcccgctg gtggtccggt tcggtgacta cggtgcgctc gggtccactc
    21481 agcacgccaa cctgccgctg ctgcagctgg cctcggtcac cggcgtgtac ggcatcacgt
    21541 tcctgatggg ctggtttgcc tcgaccgcgg tctgggcctg ggaaacccgc aacgcgcgcc
    21601 ggttcgtggt ctacggcttg gtgctggccg cggtgttcgc cgggggcgcc gcccggctcg
    21661 ccttcttcgc gcccgcggac acttcggtgc gcgtcgccgc ggtgagcccg acccgcgcgg
    21721 ccgacgagcg caccgcgagc gcactgtcca caatggaggt tgaatactgg cgggcgggcg
    21781 cggtggtggc cgcggatccc ggtggcgtcc gcgcggcctt cgcgccggtc accgacgacc
    21841 tgctcgagca gacccgccgc caggccgtgg cgggcgcgaa gatcgtgctc tggccggaaa
    21901 cccacgcccg cgtcctggag ggggaccagc gtgaactgct cgaccgcgcg accgtgatcg
    21961 cgcgggaaac cggcgcctac gtcaacctgg cgtacgcgat gtacacggcc gaagcgccga
    22021 acatccgca
//
