LOCUS       NZ_CP015163            23496 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis albispora strain WP1 chromosome, complete genome.
ACCESSION   NZ_CP015163
VERSION     NZ_CP015163.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis albispora
  ORGANISM  Amycolatopsis albispora
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Complete genome sequence and analysis of deep-sea sediment isolate,
            Amycolatopsis sp. WP1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2016) Zhejiang University of Technology, College
            of Pharmaceutical Science, Chaowang Road No.18, Hangzhou 310014,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera assembler v. unspecified
            Genome Coverage                   :: 138.17X
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:57:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,537
            CDSs (total)                      :: 8,472
            Genes (coding)                    :: 8,394
            CDSs (with protein)               :: 8,394
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 26 of 78
            Pseudo Genes (incomplete)         :: 54 of 78
            Pseudo Genes (internal stop)      :: 6 of 78
            Pseudo Genes (multiple problems)  :: 7 of 78
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:20:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3700958
            Orig. end                         :: 3724454
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015163.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23496
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="20"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23496
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23496
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13496](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13496
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(528..968)
                     /locus_tag="A4R43_RS17170"
                     /old_locus_tag="A4R43_17005"
     CDS             complement(528..968)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671609.1"
                     /locus_tag="A4R43_RS17170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17005"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_113693252.1"
                     /transl_table=11
                     /translation="MSTAITSRVCAAQTMLPMSLRPPAPPAAVSLLARARRALTEASRE
                     TEPAERFVAAYLAAHKSAAAVVAARGRPHRGRARPASVWVLLEAAVPELKEWALFFAAN
                     SATQAALLSGTSRRPSAETADELFEQSAQFLELARQAVHGSS"
     misc_feature    1077..1092
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: strong, score: 27.38"
                     /tool="antismash"
     misc_feature    complement(1078..1091)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 24.78"
                     /tool="antismash"
     misc_feature    1078..1091
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.95"
                     /tool="antismash"
     gene            1182..1703
                     /locus_tag="A4R43_RS17175"
                     /old_locus_tag="A4R43_17010"
     CDS             1182..1703
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644805.1"
                     /locus_tag="A4R43_RS17175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17010"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_113697673.1"
                     /transl_table=11
                     /translation="MSTFEHPAIAKVAAALAEAGLPSAADGIRVLPAEVRTAAQAAEAL
                     GVPVGAIANSLVFRATFDDGDGPLLALTSGAHRADVATLAELSGASAVGKADPAFVKQH
                     TGQVIGGVAPVGHPAKLTTLVDTALRQYDVVWAAAGHAKAVFPTTYAELLALTGGRAGA
                     LAGARENAHP"
     gene            1700..2284
                     /locus_tag="A4R43_RS17180"
                     /old_locus_tag="A4R43_17015"
     CDS             1700..2284
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003064527.1"
                     /locus_tag="A4R43_RS17180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17015"
                     /product="N-acetyltransferase"
                     /protein_id="WP_113693253.1"
                     /transl_table=11
                     /translation="MTATSSGYTRFARLSQAEFRARLPEALDIYVSAMRYPDGTAEQRA
                     PMWLTHALREGWRCVAALDEEDTLLGLAYGYRGSVGQWWHEQVRRGLLQREGQEAASRW
                     LGDYFELTEIHVRPDQQGAGIGEDLLRRLLDGVDNARVLLSTPEGTSRAWKLYRRVGFA
                     DVLRDYYFAGDPRAFAILGRTLPLDPPTPSN"
     misc_feature    2402..2417
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.71"
                     /tool="antismash"
     gene            2435..2593
                     /locus_tag="A4R43_RS42780"
     CDS             2435..2593
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS42780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162788501.1"
                     /transl_table=11
                     /translation="MPEQFTRPLLVLGAAGRRRRDPEHDGRRAADREDRLSRALHSLAI
                     QVRQLRR"
     gene            complement(2631..3542)
                     /locus_tag="A4R43_RS17185"
                     /old_locus_tag="A4R43_17020"
     CDS             complement(2631..3542)
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155374.1"
                     /locus_tag="A4R43_RS17185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17020"
                     /product="DMT family transporter"
                     /protein_id="WP_113697674.1"
                     /transl_table=11
                     /translation="MSVVAPAKDRAAVALVTAGVLWGTGGLAGSFLSAQGNLHPLAVAG
                     CRLLFGGLCAIGYLLVTGQLRAVPRGRAVLVRLLVVGVLLAEFQVSYFASVALTSVSLA
                     TMTTIGSVPVFVAVATTIRDRRLPAPATVAAVVIALAGLALLTSSSIGTEGTGGGGVLV
                     GGLACALAAGAGFAVLTLVNGKPVAGLEPLPTIAFGCLAGGVLLVPLSLGSVLSADWRP
                     EVMAAALFLAVCPTAVAYAAYFRGLRTAHPVVAALAALLEPLVAALLAALLLDERLGLT
                     GWCGAALLVGALGVASVRQQRG"
     gene            complement(3719..4687)
                     /locus_tag="A4R43_RS17190"
                     /old_locus_tag="A4R43_17025"
     CDS             complement(3719..4687)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803352.1"
                     /locus_tag="A4R43_RS17190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17025"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_113693254.1"
                     /sec_met_domain="PALP (E-value: 2.1e-67, bitscore: 226.6,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLPTITDVLHARQLLRPLLSPTPLSAYPALDAATGAKVRVKHEN
                     VQPTGAFKVRGGLNLLASLDPAERARGVLGYSTGNHAQSLAYAAAHHGVPCTIVMPERP
                     NPAKARAVRDLGAELIEYGERFDESRAHAETVAAERGMRLVSAANEPAIIAGVATAYVE
                     LFEQAPGLDVVLVPAGSGTGAAAAALVAAALAPDCEVIAVQSSAAPAAHDSWRAGELVD
                     RPNRTAAEGLATGSGFALTQRLLRAGLTDFLLVEDAEIARAQRLFLRAAHTVAEGAGAA
                     ALAALVANRDRFAGRSVAVVCSGGNASEAELNSMGRAAPIG"
     misc_feature    4724..4740
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.49"
                     /tool="antismash"
     misc_feature    complement(4727..4741)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.35"
                     /tool="antismash"
     misc_feature    4728..4741
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.87"
                     /tool="antismash"
     misc_feature    4729..4742
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    4729..4743
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.95"
                     /tool="antismash"
     misc_feature    complement(4733..4748)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.55"
                     /tool="antismash"
     gene            4769..5665
                     /locus_tag="A4R43_RS17195"
                     /old_locus_tag="A4R43_17030"
     CDS             4769..5665
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667078.1"
                     /locus_tag="A4R43_RS17195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17030"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_113693255.1"
                     /transl_table=11
                     /translation="MFDLVRLRVLVAVAREGSVTAAADALHYAQPSVSHHLAKLEAEAG
                     VPLLQRAGRGVRLTEAGELLVRRAEEILGQVESARAELAAHAGLRTGRVRLAAFPTALA
                     TLVPAAAAWLAAEHPGIELALTEAEPPEALTALRNGDADVALVFEHDQIPDLRNIRLTP
                     LLEEPLYAVTAASREWTGPRAELATYAGEKWIAGCPRCRAHLVGACAEAGFQPEITFET
                     DDYVAVQALVAAGLGVSTLPGLALLANRHAGVRADRLAGHQRRVLLATYGKPPLPRPVR
                     ALADALTATTGEPGWPR"
     gene            complement(5675..7348)
                     /locus_tag="A4R43_RS17200"
                     /old_locus_tag="A4R43_17035"
     CDS             complement(5675..7348)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075033.1"
                     /locus_tag="A4R43_RS17200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17035"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_113693256.1"
                     /transl_table=11
                     /translation="MVSTEHGVHAICDRYVDDLAAADPVAATTYGIAGHDHKLTDYSPA
                     GYAARATLARRALEAVEAAEPADDGERAAKAVFRERIGLELEIHEAGLDLASLNVIESP
                     VQALRMVFDLMPTATAEDWQTIATRMAAVPESLDGLRASLLTAADAGRVSALRQVSKVA
                     EQAETWAGLHGKKGYFSTLIEGAPERTPELERGARLAEEAYAELAGFLRAELAPLAPTK
                     DAVGEEVYQLWSRYFVGARLDLREAYEWGCAEFLRLEAEMREVAERIKPGGTLAEAAAT
                     LDADERYRVHGREAFERWMQNLSDDALKSLRGKHFEIPDALMALECKIAPPGGGVGAYY
                     TSPSEDFSRPGRMWWSLPEDKNEFTTWREVSTVYHEGAPGHHLQIATAVYQSASLNKYQ
                     RLVAFTSGHAEGWALYSERLMQDLGYLDDHGNLLGMLSEQLFRAARVIVDIGMHLELPI
                     ADELDFHRGERWTPDLGLEFMLKRTITDEAHVYDEIDRYLGWPGQAPSYKLGERLWLAA
                     REEARARKGESFDIKEFHTKALALGGMGLDTLREQLAQLD"
     gene            complement(7389..8273)
                     /locus_tag="A4R43_RS17205"
                     /old_locus_tag="A4R43_17040"
     CDS             complement(7389..8273)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0006555 - methionine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332694.1"
                     /locus_tag="A4R43_RS17205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17040"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_113693257.1"
                     /transl_table=11
                     /translation="MTSVVERLRGNETVFSVEFFPPRDDADEAVLWRSIRELEGFDPAY
                     MSITYGAGGTSRDGTIRSIARVATETTLVPMAHLTAVNHSVAELRNVIGWYAAVGVRNV
                     LALRGDPPGDPYGEWIAHPEGLNYAEELVALVRSLGDFCVGVSAFPYGHPRSADLETDT
                     RHLVRKFKAGADFAIAQLFFEAEDFLRLRDRVAAAGSDALMIPGIMPLTTPRTLRKTIE
                     LSGATAPKSLLDRLTPLEDDPAAFRAEGLDVVTEMCERLIAEGVPDLHFYTFNRSKATR
                     EVVSRLGLVPARA"
     misc_feature    8229..8240
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.72"
                     /tool="antismash"
     gene            complement(8335..8643)
                     /locus_tag="A4R43_RS17210"
                     /old_locus_tag="A4R43_17045"
     CDS             complement(8335..8643)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637662.1"
                     /locus_tag="A4R43_RS17210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17045"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_113693258.1"
                     /transl_table=11
                     /translation="MSTVWAGILLVAAVSVAIKAAGPALLGDRELPSWASGVIAALAPA
                     LLAGLVVTDVTGQGWTAVDWRLLAGLGVAAGAYSVRLPALPSIALAVVVTAGLRWLV"
     gene            complement(8640..9323)
                     /locus_tag="A4R43_RS17215"
                     /old_locus_tag="A4R43_17050"
     CDS             complement(8640..9323)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029308.1"
                     /locus_tag="A4R43_RS17215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17050"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_113693259.1"
                     /transl_table=11
                     /translation="MASQTSKRGYAAGIRVGAGFATATAVLGLTFGALTQTLGWGALAP
                     VAASVLVFSGSAQFALAAALAGGGGLGVAVGAAALINARFLPMGVAAAGAFKGGRLRRA
                     LEGQAVVDASWAAAHLGGGRFDREKMIGGTLVQFPAWVLGTVAGVLVAPPADVVHRFGL
                     DVVFPGFFLLLLIDELRKEPAARAVAALAVVLAAGLALVLPVGLAIVGSAAAALLGLRT
                     RRAAA"
     gene            9380..9940
                     /locus_tag="A4R43_RS17220"
                     /old_locus_tag="A4R43_17055"
     CDS             9380..9940
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018984.4"
                     /locus_tag="A4R43_RS17220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17055"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_113693260.1"
                     /transl_table=11
                     /translation="MADSWHGYRLAGGHLALDLVNTVSWRGDPPRRLDRLELPGFFADW
                     LERTGLGRPDGDLSAALPGVRELRELLYDLLADSAPRQADLDRFGELLAEAHTRAKAEP
                     ALPVRWSVRVETPDDLVPALTLRADELLRSPDTANIRQCEGRGCAWLFIDTTRNHSRRW
                     CRSDDCGNRERARRHYRRAREPV"
     gene            10001..11092
                     /locus_tag="A4R43_RS17225"
                     /old_locus_tag="A4R43_17060"
     CDS             10001..11092
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224198.1"
                     /locus_tag="A4R43_RS17225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17060"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_113693261.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.2e-47, bitscore:
                     159.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPGFDADFPAHVERALEKFLREAGDPIRAMEPSTGPGVDALSE
                     FVLGGGKRLRPTFAWWGWRGAGGDPAGPDAEGVLQAVSSLELVQACALIHDDLMDSSDS
                     RRGSPTVHVAFAKRHADHGWLGSAASFGQAAAVLLGDLALAWADDMFAAAPLPATTLAA
                     ARPAWRAMRTEVLAGQYLDVHTQATGDSSPEAALRIDRLKTAAYTVQRPLHLGAALAGA
                     DDRLIGTLLSFGRDLGVAFQLRDDLLGVFGDPSVTGKPAGDDLREGKRTLLLALGMELA
                     AAQHREAVAAVIADAVGDKDLTEDAVTEVREALTEVGAVAAVERRIDDLTAAALASLDA
                     AELAEPAATRLRELAVQATQRKY"
     gene            11092..12549
                     /gene="crtI"
                     /locus_tag="A4R43_RS17230"
                     /old_locus_tag="A4R43_17065"
     CDS             11092..12549
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671598.1"
                     /locus_tag="A4R43_RS17230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17065"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_113693262.1"
                     /sec_met_domain="DAO (E-value: 3.2e-19, bitscore: 68.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDRVVVVGAGLAGLSAALHLLGSGREVTLVEQDERPGGRAGQSA
                     RDGYRFDTGASVLTMPELVDEALAAVGESISDRMRLVRLDPAYRAHFADGSTLALRTEA
                     GAMEAEIREFAGPREAAGYRRLRTWLTELYATQKDHFIGANFDSPLDLVRPELAKLTAL
                     GGFGRLGPRVAGYLSDERVRRLFSFQALYAGLDPMRAIGAYGVISYMDTVGGVYYPMGG
                     IGKVAEAMADAAEKAGAQLKFATHAAWLERRGSHVDAVRTSAGERIPCDAVVVATELTS
                     AYQLLGAHPRRTLPLRYSPSAVVLHGHTGRSWPELDHHTIFFGGAWERTFTEIIREGRL
                     MSDPSLLVTRPTATDPALAPEGRQLVSVLAPAPNLRTGRIDWDRVGPAYREELVRTLEN
                     RGLTGFGDEFELVETSTPADWAERGFGAGTPFSLAHTFAQTGPFRPRNVLRGIENAALA
                     GCGTTPGVGIPPVLISGKLAAARILAA"
     gene            12546..13496
                     /locus_tag="A4R43_RS17235"
                     /old_locus_tag="A4R43_17070"
     CDS             12546..13496
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013674905.1"
                     /locus_tag="A4R43_RS17235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17070"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_113693263.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.7e-108,
                     bitscore: 360.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.4e-65,
                     bitscore: 220.5, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAELDAAGIHDPALRAAYTECRRINAHYGRTFFLATRLLPARAR
                     PFAHALYGFARAVDEVVDNPAPGTDPATALDAVAAQLDEVFSGRTTEFPALADTVRRFD
                     LDRSLFDAFLRSMRMDLTVTEYETYADLAEYTWGSASVIGLQMLPVFGTVSGRAEAEPS
                     AAALGEAFQLTNFLRDIGEDLDRGRVYLPRAELAAFGVDRELLESCRRRQVTDPRIRRA
                     LAAAVARNRAVYRRARLGVPLLRKESRPCVATALTLYEGILDEIVAADYHVLNRRVVVP
                     KRRRLAVAGPSLLRVQGLELLQAARNTRSPLRSKT"
     gene            13493..14281
                     /locus_tag="A4R43_RS17240"
                     /old_locus_tag="A4R43_17075"
     CDS             13493..14281
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787087.1"
                     /locus_tag="A4R43_RS17240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17075"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_113693264.1"
                     /transl_table=11
                     /translation="MTTPANRPIRVGVQIQPQHADYATIRRAASEAEDLGVDIAFNWDH
                     FYPLYGEPEGKHYECWTMLGAWAESTSRVEIGALVTCNSYRNPELLADMARTVDNISDG
                     RLILGIGSGWFEKDYTEYGYEFGTAGGRLNDLGDALPRIEARLGKLNPQPVRKIPVLIG
                     GGGEKKTLRLVAKHADIWHGFGDPEVVERKVRILDQHCADVGRDPAEIERSVAVESEPS
                     ELGPQLLERGVSLFTVGVTGPDYDFSLLRQWVEWRDKTNG"
     gene            complement(14367..15896)
                     /locus_tag="A4R43_RS17245"
                     /old_locus_tag="A4R43_17080"
     CDS             complement(14367..15896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672091.1"
                     /locus_tag="A4R43_RS17245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17080"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_113693265.1"
                     /transl_table=11
                     /translation="METLDWIVVGAYFFVMVAIGLWSKNRIQNVVDFFTAGGRMPWWLS
                     GISHHMSGYSAVMFVAFASEAYRLGLTVYVWWALTIGVGVGIGSWLFAARWNRLRAKHG
                     VASPLEYLARRFNVPTQQVMAWSGAVLKVVDIAAKWSAVAILLRGFAGVPIEVGILLVG
                     VVTMIYSVMGGLWADALTDFGQFIIQAAAGIVMFVAVAAHFGGIQFMWEIWDQLPPDRS
                     QPLNGEYTSTFFMALFVIKTLEYNGGMWNLAQRYMAAPDGAAARKSAALSSFLWLVWPL
                     VLFFPMWAAPLIVPDLTNAGDAYIELGKVMLPVGMIGLVLAGFFSHTMAMVSSDANVIS
                     AVITRDMLPRLWKGAKRMSADAQLKLARITTFVFIGLSMAIALSLDTNGGVLKVVVDLV
                     AATMGPIAVPLMLGLLPWFRRMGPVAALTSTLSGLVVWASLYISQQNGVKIPKEALVAY
                     PLLTSLVLFLVIGLVFSQRTPDRDQLVDSLSTDAPTAKPGEPGEPARVAAK"
     misc_feature    15975..15990
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.88"
                     /tool="antismash"
     misc_feature    15992..16008
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.07"
                     /tool="antismash"
     gene            complement(16138..16506)
                     /locus_tag="A4R43_RS17250"
                     /old_locus_tag="A4R43_17085"
     CDS             complement(16138..16506)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657740.1"
                     /locus_tag="A4R43_RS17250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17085"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_113693266.1"
                     /transl_table=11
                     /translation="MSAIPVADDVLEAGVAVLGVAEVAAALGQSANKVRQLLRDGQLIA
                     VRRDGELMVPADFLVGGAIVKGLGGTITVLADAGFGRTEMLRWLFAADETLPGTTPINA
                     LRTSHGTEVKRRAQAMAF"
     misc_feature    complement(16548..16565)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.59"
                     /tool="antismash"
     gene            16630..18663
                     /locus_tag="A4R43_RS17255"
                     /old_locus_tag="A4R43_17090"
     CDS             16630..18663
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671593.1"
                     /locus_tag="A4R43_RS17255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17090"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_113693267.1"
                     /sec_met_domain="Pkinase (E-value: 2.6e-44, bitscore:
                     150.5, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTETSLVGTLLDRRYRVDRLLARGGMSSVYRGVDTRLDRPVAI
                     KVMDPRFADDRSFVDRFEREARSAAKLHHPNVVAVHDQGLDNSAEVGRAFLVMELVDGG
                     TLREVLTERGPLDIALALSVAEPVLAALAAAHRAGLVHRDVKPENVLIGRGGQLGAGVV
                     KVGDFGLVRAVASAGTTSSSVILGTVAYLSPEQVTLGAASVRGDVYSAGILLYEMLTGQ
                     TPYTGDTAISVAYRHVNDDVPAPSQVRPGIPPALDQLVLRATRRDPEARPADAGAFLDE
                     LLRVRAELGIQPVPVPVPPPPDVDHESDVEKTTPHLAAIAAAPTAPAVPAVQPTAGPRA
                     TKMYDRPVPPPPPHQPPAHQPPPSPPTGTPAYQEPPPPRNRRRMYLLIGLVVVLLGGTI
                     GAASWWYSGGRYAEVPKLAGMSQAEAGDALRAVQLNPAYTKELHNTVPAGTVIRTDPDA
                     GAEVLLDEQVSVVVSEGQPVVPDIKPGADPATAEQSIRLVKLEPKLDPALDDYSPTVPK
                     GAVVKVQPTPGSKANIGDPVSIGLSKGPPPLPVPDVTGKSKDEAFKALTDAGFQPFQAG
                     EEFVQNVPAGKVSRTSPPGGTVVTGGDKRIGVYLSSAVQVPNVVGRSPKEAAKILREAG
                     LDPDFKRGKDDEGNDFNLVLETDPPAGTPVGKGTKIKIRTFL"
     gene            18660..18866
                     /locus_tag="A4R43_RS17260"
                     /old_locus_tag="A4R43_17095"
     CDS             18660..18866
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016699427.1"
                     /locus_tag="A4R43_RS17260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17095"
                     /product="hypothetical protein"
                     /protein_id="WP_113693268.1"
                     /transl_table=11
                     /translation="MIGSRGRVTGTIGPGLIGEVLLSVRGGTEAFYAYPADGEERFENG
                     TQVLVVDFEAPRTVYVQRWQPLV"
     gene            18881..20392
                     /locus_tag="A4R43_RS17265"
                     /old_locus_tag="A4R43_17100"
     CDS             18881..20392
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003100781.1"
                     /locus_tag="A4R43_RS17265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17100"
                     /product="flotillin family protein"
                     /protein_id="WP_113693269.1"
                     /transl_table=11
                     /translation="MGETDVDPLILAGVVVGAIIVLFVLLRMLYKVAEPNEALIISGWG
                     VRVQRSETADSLGFKIITGKGVLVIPGFQTARRLSLDTRGANLQVSCVTKQGLPVTVRA
                     VVIYKVGDDFASIANAARRFLDQQDGMNNTIHELFAGHLRSIVGGLTIEEMIHNRDALT
                     GEIRSSSANEMIKLGLVVDSLQIQEIDDESGYILNLGKPHAAAVAASARIAEAQRDQEA
                     TEAEQVAAAQKAGAIRESEIKQAGFQAEVDQARAKAGQSGPLAEATARQEVVVQETRAA
                     ELEAALAEQRLQSEVRKPADARAYDTRTSADAERDAAIAKAQAEAKETELRAAADATKV
                     KTAAEAEAQATKARGEASAAATRATGDAQAHAAKAQGLAEAEAARAKGLADAEAAKAKG
                     LAEADAIKARAAALAENQEAVVAQQLAERWPEIVEAGAKAFGSVDHMVVLNGADGVSDM
                     FSKALSLGGTGLGLARQLMEAMGQTSKPVEPEANGSVVPTTTDLR"
     misc_feature    20506..20526
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.95"
                     /tool="antismash"
     gene            20523..21533
                     /locus_tag="A4R43_RS17270"
                     /old_locus_tag="A4R43_17105"
     CDS             20523..21533
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156436.1"
                     /locus_tag="A4R43_RS17270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17105"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_236809224.1"
                     /transl_table=11
                     /translation="MTETMSPGVDGDFLSQADPYRRELMAHCYRMLGSVHDAEDLVQET
                     YLRAWRAYDRFEGRSSLRTWLYRIATSACLTALESRGRRPMPTGLGAPGCEPEDDLQER
                     HEVPWLEPVPDALTGADGADPAAIVTSRESIRLALVAALQHLPPRQRAVLILRDVLKWR
                     AAEVAELMDISTPAVNSILQRARAQLEKIAPTENEVTEPSAADQRELLDKFVTAFEAKD
                     IPAIISLFTEDAVWEMPPFAGWYLGAERIARHLSSRCPCRPGHTRLLPTWANGQPAFGT
                     YLRERDGERFRAFNLQVLTVGPAGISHVANFVDADLFAVFDLPESLPADYPAATA"
     gene            21552..22148
                     /locus_tag="A4R43_RS17275"
                     /old_locus_tag="A4R43_17110"
     CDS             21552..22148
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03086.1"
                     /locus_tag="A4R43_RS17275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_17110"
                     /product="TIGR03086 family metal-binding protein"
                     /protein_id="WP_113693270.1"
                     /transl_table=11
                     /translation="MPPALAGGVALLERAVGYTLGCLRLVTDESMGNATPCRDWDLRAL
                     LAHLDDALIALAEAANLGRVGLDPVAPVPGDPAAAVRARAGELLGAWMGEPAAGPVSVA
                     GAPMTAVVVAGAGALEIAVHGWDVARACGHDRPLPPALAAEMLELSALFVTAADRPERF
                     AAPIAVPAGASAGDRLLAFLGRRACSHSPGLVSRD"
ORIGIN
        1 gccctccctg gtgccggaca ggcccagctg gaagagccgg tgcgcgaacc agacgcggag
       61 cacctcgtcc accccgtcga gcgcgacgtc ctccccgatg tggccgcgtt cccgcccggc
      121 ggcctcctcc aggtcgaccc ggtgcacggt gacctcgtgc gccatccggc ggcgccagaa
      181 caaataggac tcgtcctccg gcgaccaggt ggaggcccac tcaccgggcg ggtgcgcgac
      241 cagccgggcg tgcagctcgc gcagcccggt gcgcaggtac tcctcggtcg tctgctccgc
      301 gtccggctca cgctgccagt gggcaggcgg ctcgccaccc gccagccgcg ccgtcaccac
      361 ccggcacacg ctgcccacgt gccgcagcag cccgtcggtg gtgaagccgg gacaggcggg
      421 caccggcgct tccggcgcgg tcgtgcgcgc gagctcgctc agcgactcgc cctcggtagc
      481 gatcacgtcc agcaaccggc cgggatcgac gaggtcgtgc gcccacatca actgctcccg
      541 tgcacggcct gacgggccag ctcgagaaac tgcgcgctct gctcgaacaa ctcgtcggcg
      601 gtctccgcgc tcgggcggcg gctggtgccg gacagcagcg cggcctgcgt cgcggaattg
      661 gccgcgaaga acagcgccca ctccttcagt tcgggcacgg cggcttccag cagcacccac
      721 acgctggctg gtctggcgcg accgcggtgc gggcggccac gcgcggcgac cacggccgcg
      781 gccgacttgt gcgcggccag gtaggcggcc acgaaccgct cggcgggctc ggtttcgcgg
      841 ctcgcctcgg tcagcgcccg gcgggccctg gcgagcagcg agaccgccgc cggcggcgcc
      901 ggcggtcgca gggacatcgg cagcatcgtc tgcgcggcgc acactcgtga agtgatcgct
      961 gtggacataa cggcagcctt tcgctttccc gggggaccgg gtggtcgcgg cacccggcgg
     1021 cgaaacgctt cccccgcccc gccgccgggc acctctcggc gggcgcccac cgagcgtcga
     1081 acgtatgttc gaactccaca gtaacccgtc ggcggcgatt cgccaagtgg gcggggcagg
     1141 gacgctgcgc cggcctggcg tcccgtgatc tgatggacgg catgagcacc ttcgaacacc
     1201 ccgcgatcgc caaggtggcg gccgcactcg ccgaggcggg cctgcccagc gccgccgacg
     1261 gcatccgggt actgcccgcc gaagtccgca ccgccgcgca ggccgccgaa gcgctcgggg
     1321 tgccggtcgg cgccatcgcc aacagcctgg tcttccgcgc caccttcgac gacggtgacg
     1381 gcccgctgct cgcgctcacc tccggcgcgc accgcgccga cgtggccacg ctcgccgagc
     1441 tgtccggcgc ttcggccgtc ggcaaggccg atcccgcctt cgtcaagcag cacaccggcc
     1501 aggtgatcgg cggcgtggcg ccggtcgggc acccggcgaa gctgaccacg ctggtggaca
     1561 ccgcgttgcg gcagtacgac gtggtctggg cggccgcggg ccacgcgaaa gcggttttcc
     1621 ccaccaccta cgccgaactg ctcgcgctca ccgggggtcg tgcgggcgcg ctggccggcg
     1681 cgcgggagaa tgcacacccg tgaccgcgac ctcctccggc tacacccggt tcgcccgcct
     1741 gtcccaggcg gagttccggg cgcggctccc cgaagcgctc gacatctacg tcagcgccat
     1801 gcgctatccc gacggcacgg cggagcagcg cgcgccgatg tggctgacgc acgccctgcg
     1861 cgagggctgg cgctgcgtcg ccgcgctcga cgaggaggac acgctgctcg ggctggccta
     1921 cggctaccgg ggcagcgtcg ggcagtggtg gcacgaacag gtgcggcgcg gcctgctgca
     1981 gcgcgaaggc caggaggccg ccagccgctg gctcggtgac tacttcgagc tgaccgagat
     2041 ccacgtgcgg ccggaccagc agggcgccgg tatcggcgaa gacctgctgc gccgcctgct
     2101 cgacggggtg gacaacgcca gggtgctgct gtccaccccg gagggcacca gccgggcgtg
     2161 gaagctctac cgccgcgtcg gtttcgccga cgtgctgcgg gactactact tcgccggtga
     2221 tccgcgggcg ttcgccattc tcggccgcac cctgccgctg gatccgccca cgccgtcgaa
     2281 ttgaacggtg tttttgttcg accggaattc ggtggcgaac tccggcggtt attcggcaag
     2341 gtatccgggt cgaccacgcg cgtgtaacgt cgtgcggcgc cgcgacgact cgttgggcga
     2401 atcgaattgc cgcgcgaaac ccccgaggag agagatgccc gagcaattca ccaggccgct
     2461 gctcgtgctc ggtgcggcgg gcaggcggcg ccgcgatccg gagcacgacg gacgccgcgc
     2521 cgcggaccgc gaggacaggc tgagccgcgc cctgcactcg ctcgccatcc aggtccgcca
     2581 gctccggcgc tgaccggggc ccggaccggc ggccgggccc cggccgccgg tcagccccgc
     2641 tgctgccgca ccgacgccac gccgagcgcg ccgaccagca acgccgcccc gcaccagccg
     2701 gtcaggccca accgctcatc gagcagcagg gccgccagca gcgcggcgac cagcggttcc
     2761 agcaacgcgg ccagcgccgc caccaccggg tgcgcggtgc gcagcccgcg gaagtaggcc
     2821 gcgtaggcca ccgcggtcgg gcacaccgcg aggaacagcg ccgcggccat cacctcgggc
     2881 cgccagtccg ccgagagcac cgagccgagg ctcagcggca ccagcagcac acctccggcc
     2941 aggcagccga aagcgatggt gggcaagggt tccagcccgg ccaccggctt gccgttgacc
     3001 agcgtcagca cggcgaaccc ggccccggcg gccagcgcgc aggccagtcc gccgacgagc
     3061 acaccaccgc cgcccgtgcc ttccgtgccg attgacgacg aggtcagcaa tgccagcccg
     3121 gccagcgcga tgaccaccgc ggccacggtg gccggcgcgg gcagccgccg gtcccggatg
     3181 gtggtggcca ccgcgacaaa aaccggcacg ctgccgatcg tggtcatcgt cgccaggctg
     3241 accgaggtca gcgcgaccga ggcgaagtag ctcacctgga actccgccag cagcacgccg
     3301 accaccagca accggaccag caccgcgcgc ccgcgcggca ccgcccgcag ttgcccggtc
     3361 accagcaggt acccaatggc gcacaatccg ccgaacaaca gccggcaacc ggccacggcc
     3421 aatgggtgca gatttccctg cgcactgaga aaggaaccgg cgagaccgcc cgtgccccag
     3481 agaacacccg cggtgaccaa tgcgacggca gcccgatctt tcgcgggcgc gactacggaa
     3541 atggacaaga agaacacgct ccaacgtcga agaaaagggg gaattccgac gtgcggggcg
     3601 ctggttcggc agacagcaca agaacgccgg tggtggtcga tcaccagccg gccgggcacg
     3661 ccccgctcag gagcgcgggg gtggggtgac gaggaagacc cggtgcatgg cggtgaacct
     3721 acccgatcgg cgccgcgcgg cccatcgaat tgagttcggc ctcactggcg ttgccgccgc
     3781 tgcagaccac ggccaccgac cggccggcga agcggtcccg gttggccacc agtgcggcga
     3841 gcgcggcggc acccgcgccc tcggccacgg tgtgcgcggc ccgcaggaac aggcgctggg
     3901 cccgcgcgat ctcggcgtcc tcgaccagca ggaagtcggt cagcccggca cgcaggagcc
     3961 gctgggtcag cgcgaacccg gaacccgtcg caaggccttc ggcggcggtg cggttgggcc
     4021 ggtcgaccag ctcacccgcg cgccaggaat cgtgtgcggc cggtgccgcc gacgactgca
     4081 cggcgatgac ctcgcagtcc ggcgccagag ccgcggcgac cagcgcggcg gccgccgccc
     4141 cggtgccgct gccggccggg accagcacca cgtccaggcc gggcgcctgc tcgaacagct
     4201 cgacgtaggc ggtggccacg ccggcgatga tcgccggttc gttcgccgca ctgaccagcc
     4261 gcatcccgcg ttcggcggcg accgtttccg cgtgcgcgcg ggactcgtcg aaccgttcgc
     4321 cgtactcgat cagctcggcg ccgaggtcac gcacggcccg cgccttggcc gggttcggcc
     4381 gctccggcat gacgatcgtg cacggcacac cgtggtgggc ggcggcgtag gcgagcgact
     4441 gcgcgtggtt gccggtcgag tacccgagca ccccgcgagc gcgttccgcc gggtcgagcg
     4501 aggcgagcag gttgaggccg ccacgcacct tgaacgcgcc ggtcggctgg acgttttcgt
     4561 gcttgacgcg gaccttcgcg cccgtcgccg cgtcgagcgc ggggtacgcc gacagcgggg
     4621 tcggcgaaag cagcgggcga aggagctgac gcgcgtgaag cacgtcggtg atggtcggaa
     4681 gccgcatgcc ttcaccgtcg cagcggcgag agcataggtc caatggaaat ttgtcaacaa
     4741 atcatcgacg agatctatag ttgggctcgt gttcgatctc gtccggctgc gggtgctggt
     4801 ggcggtggcc agggaaggct cggtgaccgc ggccgccgac gcgctgcact acgcgcagcc
     4861 gtcggtgagc catcacctcg cgaagctgga agccgaggct ggcgtgccgc tgctgcaacg
     4921 ggccggtcgc ggcgtccggc tcaccgaagc gggcgaactg ctggtgcggc gggccgagga
     4981 aatcctgggg caggtcgaat cggcgcgggc ggaactggcc gcgcacgccg gactgcggac
     5041 cgggcgggtg cggctggcgg cgttcccgac cgcgctggcg acgctggtcc ccgcggccgc
     5101 ggcgtggctg gcggccgagc accccggcat cgaactggcg ctcactgagg ccgaaccgcc
     5161 ggaggcgctg accgcgctgc gcaacgggga cgccgacgtg gcactggtct tcgagcacga
     5221 ccagatcccg gacctgcgca acatccggct cacgccattg ctggaggagc cgctctacgc
     5281 ggtgaccgcg gcgagtcgcg aatggaccgg gccgcgcgcg gaactggcca cctacgccgg
     5341 ggagaagtgg atcgcgggct gcccgcgctg ccgggcgcat ctggtcggcg cgtgcgcgga
     5401 agccgggttc cagcccgaaa tcaccttcga gacggacgac tacgtggccg tgcaggcgct
     5461 cgtcgccgcc gggctcgggg tgagcacgct gccggggctc gcgttgctgg cgaaccgcca
     5521 cgcgggcgtg cgtgcggacc ggctcgccgg ccaccagcgg cgcgttctcc ttgccacgta
     5581 tggaaaacca ccgctgccac ggccggtgcg ggcgctcgcc gacgcgctca ccgcgaccac
     5641 cggggaaccc ggctggccgc ggtgagccgt ccggtcagtc cagctgggcg agttgctcgc
     5701 ggagggtgtc caggcccatg ccgcccagtg ccagcgcctt ggtgtggaac tccttgatgt
     5761 cgaaggactc ccccttgcgc gcccgcgcct cctcacgggc ggcgagccac agccgctccc
     5821 ccagcttgta cgacggcgcc tgccccggcc agccgaggta ccggtcgatc tcgtcgtaca
     5881 cgtgtgcctc gtcggtgatg gtccgcttca gcatgaactc caggcccagg tccggcgtcc
     5941 agcgctcacc ccggtggaag tccagctcgt ccgcgatcgg cagttccagg tgcatgccga
     6001 tgtccacgat cacccgcgcc gcgcggaaca gctgctccga cagcatgccg agcaggttcc
     6061 cgtggtcgtc gaggtaaccg aggtcctgca tcagccgctc gctgtagagc gcccagccct
     6121 ccgcgtgccc ggaggtgaag gcgaccagcc gctggtactt gttcagcgaa gccgactggt
     6181 acaccgcggt ggcgatctgc aggtggtgcc ccggcgcgcc ctcgtggtag acggtgctca
     6241 cctcgcgcca ggtggtgaac tcgttcttgt cctcgggcag cgaccaccac atccggccgg
     6301 ggcggctgaa gtcctcgctc ggcgaggtgt agtacgcccc caccccgcca ccgggcgggg
     6361 cgatcttgca ctccagcgcc atcagcgcgt cggggatctc gaagtgcttg ccccgcaacg
     6421 acttcagcgc gtcgtcggaa aggttctgca tccaccgctc gaaggcttcg cggccgtgga
     6481 cgcggtaccg ctcgtcggcg tcgagcgtcg cggccgcctc ggcgagcgtg ccgcccggct
     6541 tgatccgctc ggcgacctcg cgcatttcgg cttccaggcg caggaactcc gcgcagcccc
     6601 actcgtaggc ctcacgcagg tccagccgcg cgccgacgaa gtaccgagac cacagctggt
     6661 agacctcttc gccgacggcg tccttggtcg gggccagcgg cgccagttcg gcgcggagga
     6721 acccggccag ctccgcgtac gcctcttcgg cgagccgcgc gccacgctcc agttccggtg
     6781 tgcgttccgg cgcgccctcg atcagcgtgc tgaaatagcc cttcttgccg tgcagcccgg
     6841 cccaggtttc cgcctgctcg gccaccttgc tgacctggcg cagcgcggac acccggccgg
     6901 cgtcggccgc ggtcagcagc gaggcacgca ggccgtcgag cgactcgggc accgcggcca
     6961 tccgggtggc gatggtctgc cagtcctcgg cggtcgcggt gggcatcagg tcgaacacca
     7021 tgcgcagggc ctgcaccggg ctctcgatca cgttcagcga ggccaggtcg agcccggcct
     7081 cgtggatctc cagctccagc ccgatccgct cgcggaagac cgccttcgcc gcgcgctcgc
     7141 cgtcgtcggc gggctcggcg gcctcgaccg cctccagcgc gcggcgggcc agcgtcgcgc
     7201 gggcggcgta cccggccggc gagtagtcgg tcagcttgtg gtcgtggccg gcgatgccgt
     7261 acgtcgtcgc ggcgacgggg tcggcggccg cgaggtcgtc tacgtagcgg tcgcagatcg
     7321 cgtgcacgcc gtgttcagtg gaaaccatgg ccgcacgcta cctggcacgc gcgggaaccg
     7381 gcagccgatt aggcgcgtgc cgggaccagc ccgagcctgc tcaccacctc gcgcgtggcc
     7441 ttcgaccggt tgaaggtgta gaagtgcagg tccggcacgc cttcggcgat cagccgttcg
     7501 cacatttcgg tgaccacgtc gaggccctcg gcgcggaagg cggctgggtc gtcttcgagc
     7561 ggggtgagcc ggtcgagcag gctcttcggc gcggtggccc cggacagctc gatggtcttg
     7621 cgcagggtcc gcggggtggt cagcggcatg atgccgggaa tcatcagcgc gtccgaaccg
     7681 gcggcggcca cgcggtcacg caggcgcagg aagtcctccg cctcgaagaa cagctgcgcg
     7741 atggcaaaat cggcgcccgc cttgaacttc cgcaccaggt gccgggtgtc ggtctccagg
     7801 tcggccgaac gcgggtggcc gtaggggaac gcggacacgc cgacgcagaa gtcgccgagc
     7861 gaacgcacca gcgcgaccag ttcctcggcg tagttcagcc cttccgggtg cgcgatccac
     7921 tcgccgtacg ggtcgccggg cgggtcgccg cgcagcgcga gcacgttgcg cacgccgacg
     7981 gcggcgtacc agccgatcac gttgcgcagt tccgccaccg agtggttgac cgcggtcagg
     8041 tgcgccatcg gcaccagcgt ggtctccgtg gccaccctgg cgatgctgcg aatggtgccg
     8101 tcgcggctgg tgccaccggc cccgtaggtg atcgacatgt aggccgggtc gaagccctcc
     8161 agctcgcgga tcgaccgcca cagcacggcc tcgtcggcgt cgtcgcgtgg tgggaagaac
     8221 tccaccgaga acacggtttc gttaccgcgc agccgttcca ccaccgaggt catagcggtc
     8281 atgctagtgg gcttagtccg gtcaatggga ccggcctccc gggtgatgag aagatcacac
     8341 cagccagcgc agcccggccg tgaccaccac ggcgagcgcg atcgacggta gcgcgggcaa
     8401 ccggacggag taggccccgg cggccacgcc cagcccggcg agcagccgcc agtcgacggc
     8461 ggtccagccc tgaccggtca cgtcggtgac caccagcccg gccagcaacg ccggcgccag
     8521 cgcggcgatc acccccgatg cccacgacgg cagctcgcga tcacccagca gcgccgggcc
     8581 cgccgccttg atcgccacgc tgaccgccgc caccagcagg atgcccgccc acaccgtgct
     8641 catgccgccg cccgccgcgt gcgcaggccg agcagcgcgg ccgcggccga gccgacgatg
     8701 gccagcccga ccggcagcac cagcgccagc ccggcggcca gcaccaccgc gagcgccgcc
     8761 accgcccgcg cggcgggttc cttgcgcagc tcgtcgatca gcaacagcag gaagaagccg
     8821 gggaacacca cgtcgaggcc gaaccggtgc accacgtccg cgggcggcgc gaccagcacg
     8881 ccggccaccg tgccgagcac ccaggccggg aactgcacca gcgtgccgcc gatcatcttc
     8941 tcccggtcga accgcccgcc gccgaggtgc gcggcggccc acgaggcgtc caccacggcc
     9001 tggccctcca gtgcccggcg cagcctgccg cccttgaagg caccggccgc ggccacgccc
     9061 atcggcagga agcgcgcgtt gatcagtgcc gccgcgccga cggccacgcc cagcccgccg
     9121 ccgccagcca gcgccgcggc cagcgcgaac tgcgcggacc cggagaacac cagcaccgag
     9181 gcggcgacgg gggcgagcgc gccccagccg agggtctggg tgagcgcgcc gaaggtcagc
     9241 ccgagcaccg cggtcgccgt ggcgaaaccg gcgccgaccc ggatcccggc ggcgtatcca
     9301 cgcttcgagg tctgggaagc catggtccca acctaacagg ctaaagcgag ttagaccatg
     9361 agagcctagg ctggcggaca tggcggacag ctggcacggg taccgactgg cgggcgggca
     9421 cctcgcgctc gacctggtca acacggtgtc gtggcgtggc gacccgccac gacggctgga
     9481 ccggctggag ttgcccgggt tcttcgcgga ctggctcgag cggaccggac tgggacggcc
     9541 ggacggcgat ctgtcagcgg ccctgcccgg cgtccgggag ctgcgtgaac tgctctacga
     9601 cctgctcgcc gacagcgcac cgcggcaggc ggatctcgac cgcttcggtg agctgctcgc
     9661 cgaggcgcac acgcgggcga aggccgagcc cgccctgccg gtccgctggt cggtgcgcgt
     9721 ggaaacaccg gacgacctcg tcccggcgct gacgctgcgt gccgacgaac tgctccgctc
     9781 ccccgacacg gcgaacatcc gccagtgcga gggacgcggt tgcgcctggt tgttcatcga
     9841 caccacccgc aaccactcgc gccggtggtg ccgctcggac gactgcggca accgcgaacg
     9901 cgcccggcgg cactaccggc gggcccgcga acccgtctga ttcaccacat ctggccaccc
     9961 cggctgggca tccatccggg tgaacacgga cgatgtaggc atgagcgagc cgggcttcga
    10021 cgccgatttc cccgcacacg tcgagcgcgc gctcgagaag ttcctgcgtg aagcgggtga
    10081 cccgatccgc gcgatggaac cgagcaccgg acccggcgtg gacgcgctga gcgagttcgt
    10141 gctcggtggt ggcaagcggt tgcggccgac cttcgcctgg tggggctggc gcggcgcggg
    10201 cggggacccg gccggcccgg acgccgaggg cgtgctgcag gcggtgtcca gcctggagct
    10261 ggtgcaggcc tgcgcgctga tccacgacga cctgatggac tcctccgact cccgccgcgg
    10321 ctcgccgacc gtgcacgtgg ccttcgcgaa gcggcacgcc gaccacggct ggctcggttc
    10381 ggcggccagc ttcggccagg ccgcggccgt gctgctcggc gacctggcgc tggcgtgggc
    10441 cgacgacatg ttcgccgccg ccccgctgcc cgcgaccacg ctcgccgccg cccggcccgc
    10501 gtggcgcgcg atgcgcaccg aggtgctcgc cgggcaatac ctggacgtgc acacccaggc
    10561 caccggcgac tcctcccccg aagccgcgct gcgcatcgac cggctgaaga ccgccgccta
    10621 caccgtgcag cgcccgctgc acctgggcgc cgcgctggcc ggggcggacg accggctgat
    10681 cggcaccctg ctctccttcg gccgcgacct cggggtcgcc ttccagctgc gggacgacct
    10741 gctcggcgtg ttcggcgacc cgtcggtgac cggcaagccc gccggggacg acctgcgcga
    10801 gggcaagcgg acgctgctgc tcgcgctcgg catggagctg gccgccgcgc agcaccgcga
    10861 ggccgtcgcg gcggtcatcg cggacgccgt cggggacaag gacctcaccg aggacgcggt
    10921 caccgaggtg cgcgaagcgc tgaccgaggt cggtgcggtc gccgcggtcg aacgccgcat
    10981 cgacgacctc accgccgcgg cgctggcctc gctcgacgcc gccgaactcg ccgaaccggc
    11041 cgccacccgg ctgcgggagc tggcggtcca ggccacgcag aggaagtact agtgaccgac
    11101 cgagtcgtgg tggtcggcgc cggcctcgcc gggctgtcgg ccgcactgca cctgctgggt
    11161 tccggccgcg aggtgaccct cgtcgagcag gacgagcgcc ccggcggccg cgccggccag
    11221 tccgcgcgcg acgggtaccg cttcgacacc ggcgccagcg tgctcaccat gccggaactg
    11281 gtggacgagg cgctggccgc ggtcggtgag tccatttcgg acagaatgcg gctggttcgc
    11341 ctcgatccgg cctaccgcgc gcacttcgcc gacggcagca cgctcgcgct gcgcaccgaa
    11401 gccggcgcga tggaagccga gatccgcgag ttcgccggac cgcgggaggc cgcgggctac
    11461 cggcgcctgc gcacctggct gaccgagctg tacgcgacgc agaaggacca cttcatcggc
    11521 gcgaacttcg actcgccgct cgacctggtc cgcccggaac tggcgaagct gaccgcgctc
    11581 ggcgggttcg gcaggctcgg cccgcgcgtg gccggatacc tgtccgacga acgcgtgcgg
    11641 cggctgttct ccttccaggc gctctacgcc gggctcgacc cgatgcgcgc gatcggggcc
    11701 tacggcgtca tttcctacat ggacaccgtg ggcggggtgt actacccgat gggcgggatc
    11761 ggcaaggtcg ccgaggcgat ggcggacgcc gccgaaaaag ccggggcaca gctgaagttc
    11821 gccacgcacg cggcctggct ggagcgccgc gggtcccatg tggacgctgt gcgcaccagc
    11881 gcgggcgagc ggatcccgtg tgacgcggtg gtcgtggcca ccgagctgac ctcggcgtac
    11941 cagctgctcg gcgcgcaccc gcggcggacg ctgccgttgc ggtactcgcc gtcggcggtg
    12001 gtgctgcacg ggcacaccgg ccggtcgtgg ccggaactgg accaccacac catcttcttc
    12061 ggcggcgcct gggaacggac cttcaccgag atcatccgcg agggcaggct gatgagcgat
    12121 ccgtcgctgc tggtcacccg gccgaccgcg accgacccgg cgctggcgcc cgagggccgt
    12181 cagctggttt ccgtgctggc acccgcgccg aacctgcgga ccgggcggat cgactgggac
    12241 cgcgtcggcc cggcctatcg cgaggaactg gtgcggacac tggaaaaccg cggcctgacc
    12301 gggttcggcg acgagttcga gctggtcgag acgagcacgc ccgccgactg ggccgagcgc
    12361 gggttcggcg ccggtacgcc gttctcgctg gcgcacacct tcgcccaaac cggaccgttc
    12421 cggccacgca atgtgctgcg cggcatcgaa aacgccgcgc tcgccgggtg cgggaccacc
    12481 ccgggcgtcg gcatcccgcc ggtgctgatc tccggaaagc tcgccgcggc aaggattctc
    12541 gccgcatgag cgccgaactc gacgccgcgg gcatccacga ccccgccctg cgtgccgcct
    12601 acaccgaatg ccgccggatc aacgcgcact acggccgcac cttcttcctg gcgacccggt
    12661 tgctcccggc cagggcccgc ccgttcgcgc acgcgctgta cggcttcgcc agggcggtcg
    12721 acgaggtggt cgacaatccc gcgcccggca ccgatccggc caccgcactg gacgcggtgg
    12781 ccgcgcagct ggacgaggtg ttctccgggc ggaccacgga attccccgcg ctggccgaca
    12841 ccgtgcgccg gttcgacctc gaccgctcgc tgttcgacgc cttcctgcgg tccatgcgga
    12901 tggacctgac ggtgaccgaa tacgagacct acgccgacct cgccgagtac acctggggct
    12961 cggcctcggt gatcggcctg cagatgctgc cggtgttcgg cacggtgagc gggcgcgcgg
    13021 aagccgagcc gagcgccgcc gcgctcgggg aagccttcca gctgaccaat ttcctgcgtg
    13081 acatcggcga agacctcgac cgcggccggg tttacctgcc gcgtgccgaa ctcgcggcgt
    13141 tcggcgtgga ccgggaactg ctcgaatcct gccgccgtcg ccaggtcacc gacccccgga
    13201 tccggcgcgc gctggccgcg gcggtggcgc gcaaccgcgc ggtctaccgg cgggcccgcc
    13261 tcggcgttcc gttgctgcgc aaggaatccc ggccgtgcgt ggcgaccgcg ctgacgttgt
    13321 acgaaggcat cctggacgag atcgtggcgg cggactacca cgtgctcaac cgccgggtcg
    13381 tggtgccgaa gcggcggcgg ctcgcggtgg ccgggccgag cctgctccgc gtgcaggggc
    13441 tggagttgct tcaggcagcg cggaacacca gatcaccact acgctcgaaa acatgacgac
    13501 acccgccaac cggccgatcc gggtcggagt ccagatccag ccccagcacg ccgactacgc
    13561 caccatccgc cgggccgcgt ccgaggccga ggacctcggc gtcgacatcg ccttcaactg
    13621 ggaccacttc tacccgctct acggggaacc cgaaggcaag cactacgagt gctggaccat
    13681 gctcggcgcc tgggccgaat ccacctcgcg ggtggagatc ggcgcgctgg tcacctgcaa
    13741 cagctaccgc aaccccgaac tgctcgccga catggcgcgc acggtcgaca acatcagcga
    13801 cggcaggctg atcctcggga tcggctccgg ctggttcgag aaggactaca ccgaatacgg
    13861 ctacgagttc ggcaccgccg gcggcaggct gaacgacctc ggtgacgcgc tgccgcgcat
    13921 cgaagccagg ctcggcaagc tgaacccgca gccggtgcgc aagatcccgg tgctgatcgg
    13981 cggcggcggg gagaagaaga cgctgcgcct ggtggccaag cacgccgaca tctggcacgg
    14041 cttcggcgac ccggaggtgg tggagcgcaa ggtgcgcatc ctcgaccagc actgcgccga
    14101 cgtcggccgc gacccggcgg agatcgagcg ttcggttgcg gtcgagtcgg agcccagcga
    14161 actcgggccg cagctgctcg agcgcggggt ctcgctgttc accgtcggcg tgaccggccc
    14221 cgactacgac ttctccctgc tgcggcagtg ggtcgaatgg cgggacaaga ccaacggctg
    14281 aggcccgccc gccccgccga acgtcacgaa tgtggctttc gagacgcaga acgtctcgaa
    14341 agccacattc gtgacatcgg ccggggttac ttcgcggcca ccctggcggg ttcgcccggt
    14401 tcgccgggct tggccgtcgg cgcgtcggtg gacagcgagt ccaccagctg gtcgcggtcc
    14461 ggggtgcgct gcgagaagac cagcccgatc accaggaaca gcaccagcga ggtgagcagc
    14521 gggtaggcca ccagcgcctc cttcgggatc ttcaccccgt tctgctgcga gatgtacagg
    14581 ctcgcccaca ccaccagccc gctcagcgtg gaggtcagcg cggccaccgg gcccatccgg
    14641 cggaaccacg gcagcaggcc cagcatcagc ggtaccgcga tcggtcccat cgtggccgcc
    14701 accaggtcga ccaccacctt gagcaccccg ccgttggtgt ccagtgacaa cgcgatcgcc
    14761 atgctcagcc cgatgaacac gaacgtggtg atccgcgcca gtttcagctg cgcgtccgcg
    14821 ctcatccgtt tcgcgccctt ccacagcctg ggcagcatgt cgcgggtgat caccgccgag
    14881 atcacgttgg cgtccgagga caccatcgcc atggtgtgcg agaagaaccc ggccagcacc
    14941 agcccgatca tgccgaccgg cagcatcacc ttgcccagtt cgatgtaggc gtcaccggcg
    15001 ttggtcaggt ccggcacgat cagcggcgcg gcccacatcg ggaagaacag caccagcggc
    15061 cagaccagcc acaggaagct ggacagcgcc gcggacttgc gggccgccgc cccgtccggc
    15121 gcggccatgt agcgctgcgc caggttccac atgccgccgt tgtactccag cgtcttgatc
    15181 acgaacagcg ccatgaagaa ggtcgaggtg tactcgccgt tgagcggctg gctccggtcg
    15241 ggcggcagct ggtcccagat ctcccacatg aactggatgc cgccgaagtg cgcggccacc
    15301 gccacgaaca tcacgatgcc cgccgcggcc tggatgatga actggccgaa gtcggtgagc
    15361 gcgtcggccc acagcccgcc catcaccgag tagatcatgg tgaccacgcc gaccagcagg
    15421 atgccgacct cgatcggcac gccggcgaac ccgcgcagca ggatcgccac cgcggaccac
    15481 ttcgccgcga tgtcgaccac cttgagcacc gcaccggacc acgccatcac ctgctgcgtc
    15541 ggcacgttga agcgccgcgc caggtactcc agcggggagg ccacgccgtg cttggcgcgc
    15601 agccggttcc agcgggcggc gaacagccag ctgccgatgc ccacgccgac gccgatggtc
    15661 agcgcccacc agacgtagac ggtcaggccc agccggtagg cctcactggc gaacgccacg
    15721 aacatgacgg cgctgtagcc cgacatgtgg tgcgagatcc cggacagcca ccacggcatc
    15781 cggccgccgg cggtgaagaa gtcgaccacg ttctggatgc ggttcttcga ccacaggccg
    15841 atcgccacca tcacgaagaa gtaagcgccg accactatcc agtcgagcgt ctccatcgca
    15901 cctccctgag ttcacccgcg cgagttgtgt gacgtacgtc ttacgagggg atttcggtcg
    15961 ttggaagtct cggctgggaa gtgaatcaca cttgtgactt actttcacat acatgaacac
    16021 tttccaggcg tgcggaagcg ccggtggggc gggcacagcc ggatttcacc cgttcggccg
    16081 cgcgagcgga cgacgggtca gggactagct cggtactagc gctgtcctag ctcagggcta
    16141 gaaggccatc gcctgcgcgc ggcgcttgac ctcggtgccg tggctggtgc gcaacgcgtt
    16201 gatcggcgtg gtgccgggca gcgtctcgtc cgcggcgaac agccagcgga gcatctcggt
    16261 gcggccgaac ccggcgtcgg ccagcacggt gatggtgccg ccgaggccct tcacgatcgc
    16321 gcctccgacc aggaagtccg ccgggaccat cagctcgccg tcgcgccgga cggcgatcag
    16381 ctggccgtcc cgcagcagct gccggacctt gttggccgac tggcccagcg cggcggccac
    16441 ttcggccacc ccgagcacgg ccaccccggc ctcgagcacg tcatcagcga caggaatcgc
    16501 actcacaccc gacactgtgc cacagcgagc cctccggcac cgatggcgta acgaaacctc
    16561 aacaaggcca accatcaccc ggcagggcac gtccccaggt gcatgggcac atccgtacga
    16621 tcgtcaaccg tgacacgcac ggaaaccagc ctggtcggca cgctgctcga ccggcggtat
    16681 cgggtcgacc ggctgctcgc ccgcggtggc atgtcctcgg tgtaccgcgg cgtggacacc
    16741 cggctggacc ggcccgtggc gatcaaggtc atggacccgc ggttcgccga cgaccgctcc
    16801 tttgtggacc gcttcgagcg cgaagcgcgg tcggcggcca agctgcacca cccgaacgtg
    16861 gtcgccgtgc acgaccaggg cctggacaac tccgccgaag tcggccgcgc cttcctggtg
    16921 atggaactgg tcgacggcgg cacgctgcgt gaggtgctca ccgagcgggg gccgctggac
    16981 atcgcgctgg cgctgtcggt ggccgagccg gtgctcgccg cgctcgccgc cgcgcaccgc
    17041 gccgggctgg tgcaccgcga cgtcaaaccc gagaacgtgc tcatcggccg cggcggccag
    17101 ctcggcgccg gcgtggtgaa ggtgggcgac ttcggcctgg tccgcgccgt ggccagcgcg
    17161 ggaaccacca gctccagcgt cattctcggc acggtcgcct acctctcccc cgagcaggtc
    17221 acgctcggcg cggcgagcgt gcgcggcgac gtgtactccg cgggcatcct gctctacgag
    17281 atgctcaccg ggcagacccc gtacaccggc gacacggcga tttcggtggc ctaccggcac
    17341 gtgaacgacg acgtaccggc gccgagccag gtccgccccg gcattccgcc cgcgctggac
    17401 cagctcgtcc tgcgggccac ccgccgcgat ccggaggccc ggcccgccga cgcgggcgcc
    17461 ttcctcgacg aactcctgcg ggtgcgtgcc gagctgggca ttcagccggt tccggtgccg
    17521 gtgccgccgc ccccggacgt ggaccacgaa tccgacgtgg agaagaccac cccgcacctg
    17581 gccgcgatcg ccgccgcgcc gaccgccccg gccgtgcccg ccgtgcagcc gacggccggg
    17641 ccgcgggcca cgaagatgta cgaccggccg gtgccaccac cgccaccgca ccagccgcca
    17701 gcgcaccagc cgccgccgtc gccgcccacc ggcacgcccg cctaccagga gccaccgccc
    17761 ccgcgcaacc ggcggcggat gtacctgctg atcgggctgg tcgtggtgct gctcggtggc
    17821 acgatcggcg cggcgtcctg gtggtactcc ggcggccggt acgccgaggt gccgaagctg
    17881 gccggcatgt cgcaggccga ggcgggcgac gcgttgcgcg cggtccagct gaacccggcc
    17941 tacaccaagg aactgcacaa cacggtgccc gcgggcacgg tcatccggac cgatcccgac
    18001 gccggtgccg aggtgttgct cgacgagcag gtgtcggtgg tcgtctccga gggccagccg
    18061 gtggtgcccg acatcaagcc gggcgccgac ccggccaccg cggagcagtc gatccggctg
    18121 gtcaagctgg agccgaagct ggacccggcg ctcgacgact acagcccgac cgtgcccaag
    18181 ggcgcggtgg tcaaggtgca gccgaccccg ggcagcaagg ccaacatcgg cgacccggtg
    18241 tcgatcgggc tgtccaaggg cccgccgccg ctgccggtgc cggacgtcac cggcaagagc
    18301 aaggacgagg cgttcaaggc gctgaccgac gccgggttcc agccgttcca ggccggtgag
    18361 gagttcgtgc agaacgtgcc ggccggcaag gtcagccgga ccagcccgcc cggcggcacc
    18421 gtggtgaccg gcggggacaa gcggatcggc gtgtacctct ccagcgcggt gcaggtgccg
    18481 aacgtggtcg gccgctcacc gaaggaagcg gcgaagatcc tgcgcgaggc cgggctcgac
    18541 ccggacttca agcgcggcaa ggacgacgag ggcaacgact tcaacctggt gctggagacc
    18601 gatccaccgg caggcacccc ggtcggcaag gggaccaaga tcaagatcag gacgttcctg
    18661 tgatcggcag ccgcggccgg gtcaccggca ccatcggacc cggcctgatc ggcgaggtgc
    18721 tgctgtccgt gcggggtggc acggaggcgt tctacgccta cccggccgac ggtgaagaac
    18781 gatttgaaaa cggaacccag gtcctggtgg tggacttcga ggcgccgcgt acggtctacg
    18841 tccagcgctg gcagccactc gtctgaccag ccacttctga ctgggggaga ctgacgtgga
    18901 tccgctgatc ctcgccggcg ttgtcgtcgg cgccatcatc gtgctgttcg tcctgctgcg
    18961 catgctgtac aaggtcgccg agcccaacga ggcgctgatc atctcgggct ggggcgtgcg
    19021 cgtgcagcgc tcggaaaccg cggacagcct ggggttcaag atcatcaccg gcaagggcgt
    19081 gctggtgatc cccggcttcc agaccgcgcg gcggctgtcg ctggacacca ggggcgccaa
    19141 cctgcaggtc tcgtgcgtga ccaagcaggg cctgccggtg accgtgcggg cggtggtgat
    19201 ctacaaggtg ggcgacgact tcgcctcgat cgccaacgcc gcgcgccggt tcctcgacca
    19261 gcaggacggc atgaacaaca ccatccacga gctgttcgcc gggcacctgc gctcgatcgt
    19321 cggcgggctg accatcgagg agatgatcca caaccgggac gcgctcaccg gggagatccg
    19381 cagttcctcg gcgaacgaga tgatcaagct cgggctggtg gtggactcgc tgcagatcca
    19441 ggagatcgac gacgagtcgg gttacatcct gaacctgggc aagccgcacg cggccgcggt
    19501 ggccgcctcc gcccgcatcg ccgaggcgca gcgcgaccag gaggccaccg aggccgagca
    19561 ggtcgccgcc gcgcagaagg cgggcgcgat ccgcgagagc gagatcaagc aggccgggtt
    19621 ccaggccgaa gtggaccagg cgcgggcgaa ggcgggccag tcgggtccgc tggccgaggc
    19681 gaccgcccgc caggaggtcg tggtgcagga gaccagggcg gcggagctgg aggccgcgct
    19741 ggccgagcag cggctgcagt cggaggtccg caagcccgcc gacgcgcgcg cctacgacac
    19801 caggacctcc gcggacgccg agcgcgacgc ggcgatcgcc aaggcgcagg ccgaggccaa
    19861 ggagaccgag ctgcgggcgg cggccgacgc gaccaaggtg aagaccgccg ccgaggccga
    19921 agcgcaggcc accaaggcac gcggtgaagc gagcgccgcg gcgacgaggg caaccggtga
    19981 cgcccaggcg cacgcggcga aggcacaggg cctggccgag gccgaagccg ccagggcgaa
    20041 gggtctcgcc gacgccgagg cggccaaggc gaagggcctc gccgaggcgg acgccatcaa
    20101 ggcgcgggcc gcggcgctgg cggagaacca ggaagccgtg gtggcgcagc agctggccga
    20161 acgctggccg gagatcgtcg aagccggggc gaaggccttc ggcagcgtgg accacatggt
    20221 ggtgctcaac ggcgccgacg gtgtgtccga catgttcagc aaggcgctct cgctgggcgg
    20281 caccggactc ggcctggccc gccagctgat ggaggcgatg ggccagacca gcaagccggt
    20341 ggagccggag gccaacggct cggtggtgcc caccaccacc gacctgcgct gaaccgatcg
    20401 cgggctggac acgtatttcc cgccgaccga tgagttcgcc gcccgcgtcc ggtcaatacc
    20461 gctgacggag ccatctgggc ggcctaggat tcggcaaggc gggaggaaag gtcgtggtga
    20521 cgatgacgga gacgatgagc ccgggggtcg acggtgactt cctcagccag gccgatccgt
    20581 accggcgcga gctgatggcg cactgctacc ggatgctcgg ctcggtgcac gacgccgagg
    20641 acctggtgca ggagacctac ctccgcgcct ggcgtgccta cgaccgcttc gagggccgct
    20701 cctcgctgcg cacctggctc taccgcatcg ccaccagcgc ctgcctgacc gcgctggaga
    20761 gccgcggcag gcgtccgatg ccgaccgggc tcggcgcgcc cggctgcgag cccgaggacg
    20821 acctccagga acgccacgag gtgccgtggc tggagccggt gcccgacgcg ctgaccgggg
    20881 ccgacggcgc cgacccggcg gcgatcgtca cctcgcgcga gagcatccgg ctggcgctgg
    20941 tggccgcgct gcagcacctg ccgccgcgtc agcgtgccgt gctcatcctc cgtgacgtgc
    21001 tgaagtggcg ggccgccgag gtcgccgagc tgatggacat ctccaccccg gcggtgaaca
    21061 gcatcctgca gcgcgcccgc gcccagctgg agaagatcgc gccgaccgag aacgaggtga
    21121 ccgagccgtc ggcagccgac cagcgcgaac tgctcgacaa gttcgtcacc gccttcgagg
    21181 ccaaggacat cccggcgatc atctcgctgt tcaccgagga cgcggtctgg gagatgccgc
    21241 cgttcgccgg ctggtacctc ggcgccgagc ggatcgcgcg ccacctgagc agccggtgcc
    21301 cgtgccgccc cggccacacc cgcctgctgc ccacctgggc caacgggcag cccgcgttcg
    21361 gcacctacct gcgcgagcgc gacggcgagc ggttccgcgc gttcaacctc caggtgctca
    21421 ccgtcggccc ggccgggatc agccacgtgg cgaacttcgt ggacgcggac ctgttcgcgg
    21481 tgttcgacct gccggagtcg ctgcccgccg actacccggc cgccacggcc tgagccaccg
    21541 ccgtgtcccc catgccgccc gcgctggccg gcggggtcgc cctgctggag cgcgccgtcg
    21601 gttacacgct gggctgcctg cggctggtca ccgacgagtc gatgggcaac gccaccccgt
    21661 gccgggactg ggacctgcgt gcactgctgg cgcatttgga cgacgcgctc atcgcgctgg
    21721 ccgaagctgc caacctcggc cgcgtcggcc tcgacccggt ggcgccggtg ccgggtgatc
    21781 cggcggctgc cgtgcgggca cgggcgggtg aacttctcgg cgcctggatg ggtgaaccgg
    21841 cggcgggtcc ggtctcggtg gcgggggcgc cgatgaccgc ggtcgtggtt gccggtgccg
    21901 gggcgctgga gatcgcggtg cacggctggg acgtcgcgcg cgcctgcggg cacgaccgtc
    21961 cactaccgcc cgcgctcgcc gcggaaatgc tcgagctttc cgcactgttc gtcaccgccg
    22021 ccgaccgtcc ggagcgattc gccgcaccga tcgcagtacc cgccggggcg tccgccggtg
    22081 accgcctgct cgcttttctg ggccggagag cttgctcaca ctcgcccggg ctagtcagcc
    22141 gagattagtt acctggcaac ggtttcaccg cgtttagggc aaaaggcggc tgcctccggc
    22201 cggggatcgg cgggaaactc gacagcgagg aatccccgga agatcgaatg tcctcctttc
    22261 gagtgaacga gaggatgcgt tatccccgtg gaaacacccc gaccattccc ctgacacgtc
    22321 atgctgatga actggttgcc gattccacga accattccag ggaggtctga tcgatgctcg
    22381 acggccagct cagcggactc gatgtggcct tcctctgcct ggagggcgaa cgcaccccga
    22441 tgcacatggg cgcggtggtg accttcgacg ggccggccga caccgcgcac ctcggccggt
    22501 tgctcgccgc tcgcgcggcg cggattccca agctgcgcaa gcacattcgc cccacgctgc
    22561 tgccgccggg cggcgcggcc tgggccgagg accccggctt cgaccccgcc gaccacatcc
    22621 acgtgcacca cgtttcctcg ctgtacgaac cggaaccgct cgccgccttc gcttcactgt
    22681 ggatcgccga accgctcgac atggaccgcc cgctgtggga cctgtgcctg gtgaccgggc
    22741 tgcccgacgg ccggttcgcg gtactgctca agctgcacca cgcgctcacc gacggcgccg
    22801 gcgccttctc gatcgggtcg ggcctgctcg acgaactgcc cggcgcccgc acgcctcgcg
    22861 ccaccgccgc caagccggtc gccgccaagc cgccgcgcag tccgctgggc ctgctcaagg
    22921 acggcttctc cgccgtcgtc gcccaagcca ccgaaggcgc gtcgatcgcg tcgtcggtgc
    22981 tgcgggccgc gcggccgtac ccgacctcac cgatctccgc gccgaacgcc gacgaacgct
    23041 gcctcggctt cgtccgcctg gacctggccg atctccgccg ggtgcgcaag gcacacggcg
    23101 gcaccaccaa cgacgtggtg ctggccatcg tggccggtgc gctgcgcagc tggctggtca
    23161 accgcgggca gcgcgcggac gatcgcacgc tgcgtgcgct gatcccggtc agcgtgcgcg
    23221 cgcggcagca gggcagcacc gacggcaacc agctctcggg ttacctgtgc gacctgccgg
    23281 tcggcctgga cgacccggtg gcgcggctgc acgcggtgcg ccggtcgatg gaccacgcca
    23341 aggccaaggg caccgcgacc gggccgggtg ccttcccgat cctggcgaac cggctgcccg
    23401 cgccggtgca ccgcctggcc accagggcgg ccgggcgggc ggcgccgctg ctgttcgaca
    23461 ccgtggtgac gaacgtgccg atgcccggcc gtccgc
//
