LOCUS       NZ_CP015163            22033 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis albispora strain WP1 chromosome, complete genome.
ACCESSION   NZ_CP015163
VERSION     NZ_CP015163.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis albispora
  ORGANISM  Amycolatopsis albispora
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Complete genome sequence and analysis of deep-sea sediment isolate,
            Amycolatopsis sp. WP1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2016) Zhejiang University of Technology, College
            of Pharmaceutical Science, Chaowang Road No.18, Hangzhou 310014,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera assembler v. unspecified
            Genome Coverage                   :: 138.17X
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:57:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,537
            CDSs (total)                      :: 8,472
            Genes (coding)                    :: 8,394
            CDSs (with protein)               :: 8,394
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 26 of 78
            Pseudo Genes (incomplete)         :: 54 of 78
            Pseudo Genes (internal stop)      :: 6 of 78
            Pseudo Genes (multiple problems)  :: 7 of 78
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:20:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2020424
            Orig. end                         :: 2042457
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015163.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22033
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="11"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22033
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22033
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12033](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12033)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(952..966)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    2894..2908
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.03"
                     /tool="antismash"
     misc_feature    2941..2955
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    3026..3041
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.0"
                     /tool="antismash"
     misc_feature    complement(3963..3976)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.95"
                     /tool="antismash"
     gene            complement(4076..5401)
                     /locus_tag="A4R43_RS09360"
                     /old_locus_tag="A4R43_09280"
     CDS             complement(4076..5401)
                     /EC_number="6.3.4.20"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueC"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF018242.4"
                     /locus_tag="A4R43_RS09360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09280"
                     /product="7-cyano-7-deazaguanine synthase"
                     /protein_id="WP_162788387.1"
                     /sec_met_domain="QueC (E-value: 4.2e-05, bitscore: 22.1,
                     seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVARRFAFTASGRHRTDSDREPLCDADFHDREARLDQGMTMAG
                     PAEPWARDLLQVARAVYLVDKRYVRRTEDGWSRAVDLSVEVAEPERWGAAQLEDLATLL
                     ATLTSDTWQVRVVGGAAYRQWFDYEERVSEVALFSGGLDSTSYAAQASAQGNDAGTLLL
                     MGYDDNMRARQQEVWRSVDRVRNRPVKLVQIGQRVLSGPGGELEPSTRTRGLLYTATAV
                     AAASAHGVGQVNAPENGQLAINPPLTPNRLAGLSTRSVHPWTLELTNRVIRGLGGAVEV
                     VNPLLSFTKGEVCGQALEAGLSPEDLARTVSCGDPSSARYSQAPPNCGHCFPCLVRRSG
                     LAWAAGIDRTDYRIELGGIDMRARAAEHLRALARWLASDFGFRDLVADMPFPSSTPIPA
                     VLPMLHRGRRELAAMVDQVIPQNSLLRRTWAPKLVGRAPSTA"
     gene            complement(5398..6015)
                     /locus_tag="A4R43_RS09365"
                     /old_locus_tag="A4R43_09285"
     CDS             complement(5398..6015)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS09365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_09285"
                     /product="hypothetical protein"
                     /protein_id="WP_113691961.1"
                     /transl_table=11
                     /translation="MEALAAAVREDPNAYGLRATMVRAGGSLIDAVEGLGSGGGPVNLV
                     VGSGWSGTPGEWFLYQFVSVVAGEGTTIADALARRSATACAERILADPATRGAIERQTS
                     DWNFADSLFCEVYQLFFADYVAAFVRAVIAEKVKLVVPALVLVDPSGQIADWVADQVAA
                     VLPMPCAEKEKQRDDPRSITEIARDMLQDTVSAALGLPGGIT"
     gene            6906..8402
                     /locus_tag="A4R43_RS09370"
                     /old_locus_tag="A4R43_09290"
     CDS             6906..8402
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021375.4"
                     /locus_tag="A4R43_RS09370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09290"
                     /product="DNA/RNA helicase domain-containing protein"
                     /protein_id="WP_205215284.1"
                     /transl_table=11
                     /translation="MDAYEKHKKHPAVQVHENLLALKVHHSMFDDRYVNLVGASYLHNL
                     KEPEYQWIRHVSPRNGIPTFTVRSPGELGKFLRDNFSAQSGADAAEALLDRRRSNSLIE
                     PEVGAIVAGHTKFSLVENQLTAVTTVAEALDSWAPVGTKKVFVVSGRAGSGKSLIALTL
                     LGQALNARREACYVSGGIASRETFKRASNGRRQAFATLNNIADNRAANELDLILCDEAH
                     RLTERPMKGSYSMRPGESSVSVVVTRAKVPVFFIDGDQRLFSDEVWSPEALTSELHDLG
                     TEVVPITLDRVLRAVGSATYDTWVQHLLAGDPLPWKPDGGNDPEPFQLYYSDSAATMER
                     FLRDKENEGESARISAGICWKWEDRSGTDPEVNPEPGWARPWNAGDQHNTPGVPKRRFW
                     ATEPGGFGQIGCVHTAQGLEYEWGGVIMGPDLTWDGGSWKVHREHVRSKANRINADEDL
                     RRAIRNAYGVLMTRSIRGTVLYSVDSATRKLFADLGVHKL"
     gene            complement(8821..9159)
                     /locus_tag="A4R43_RS09380"
                     /old_locus_tag="A4R43_09300"
     CDS             complement(8821..9159)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673382.1"
                     /locus_tag="A4R43_RS09380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09300"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_113691963.1"
                     /transl_table=11
                     /translation="MQDPCQAREVLGIVGDKWALLIVRMLKDGPRRFTELKRSIDGIRQ
                     RMLTVTLRDLERDGILTRTVRNVMPPHVSYELTTMGRTLREATAPLLEWSITHLPHIDA
                     ARAAYDSR"
     gene            9278..9979
                     /locus_tag="A4R43_RS09385"
                     /old_locus_tag="A4R43_09305"
     CDS             9278..9979
                     /NRPS_PKS="Domain: Abhydrolase_1 (2-105). E-value: 2.5e-18.
                     Score: 58.5. Matches aSDomain:
                     nrpspksdomains_A4R43_RS09385_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673381.1"
                     /locus_tag="A4R43_RS09385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09305"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_113691964.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-17, bitscore:
                     64.0, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 8.7e-14, bitscore: 50.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATFLLVHGAWHSGRSWDRVVPLLESAGHRVLAPSLTGYGDQAHL
                     LSPEVGLGTHVDDIVGLIEAERLDDVVLVGHSYAGMVISGVAHRVPERIAHLVFLDAMV
                     PEDGEAAVDVHPVTKQLVDLAVDGWRVPPMPEQPPPLGLFGVTDPEDVAWLRSMLSDQP
                     VRCLLEPARLDNPAARTIPRTHIHCLADRPAGITRRPVPAGERVRELPTGHDCMITMPA
                     ELTELLVEAAR"
     aSDomain        9284..9592
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS09385_Abhydrolase_1.1"
                     /evalue="2.50E-18"
                     /label="A4R43_RS09385_Abhydrolase_1.1"
                     /locus_tag="A4R43_RS09385"
                     /protein_end="105"
                     /protein_start="2"
                     /score="58.5"
                     /tool="antismash"
                     /translation="TFLLVHGAWHSGRSWDRVVPLLESAGHRVLAPSLTGYGDQAHLLS
                     PEVGLGTHVDDIVGLIEAERLDDVVLVGHSYAGMVISGVAHRVPERIAHLVFLDAMVP"
     gene            complement(10001..11035)
                     /locus_tag="A4R43_RS09390"
                     /old_locus_tag="A4R43_09310"
     CDS             complement(10001..11035)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.4"
                     /locus_tag="A4R43_RS09390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09310"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_113691965.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-63, bitscore:
                     213.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPAFESAPVNPGVVLARRLLPPVLGEWIDRLGGELATVCGYQL
                     GLCDDTGRPTGGVSGKLLRPAFALLCGAATGARPADVVPSGAAIELLHNASLIHDDIMD
                     GDRERRHRPTVWARFGEATAILAGDALIALGFEVLAAQRHAATARSVTLLAKTLRLLAR
                     GQELDLRFESETGVTVDECLAMMTGKTGVLLGCACRLGVAHSGAPAEWAVRFERFGVHL
                     GVAFQLADDLLGIWGDPAVTGKPVGADLRARKKSAPVAAALAAGTAGSARIASLYAKPE
                     ALTDAEVAQLTELVEEAGGREWTRAEADRRVSAAWDLIDVLDLDGPARAGLAALTGSLL
                     DRDH"
     gene            complement(11032..12033)
                     /locus_tag="A4R43_RS09395"
                     /old_locus_tag="A4R43_09315"
     CDS             complement(11032..12033)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="A4R43_RS09395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09315"
                     /product="terpene cyclase"
                     /protein_id="WP_113691966.1"
                     /sec_met_domain="T1TS (E-value: 1.3e-82, bitscore: 277.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPVTRMVEAFEAIAPECNPHADAATAHLNRWVGEQGLIGRAAA
                     RERFDRAAFGWFAAITYPTASERDLGLVADWFAWLFLLDDQLDDGVLGRDPERTHQFLG
                     ALFGVLEGKGADPAGPSIVTSLADLWDRTTETASEAWRRRFVEHVVAGGLAAGWESANR
                     VSGTIPGEADYVEKRRHTGAIYVCFDLIEIAEHLDVPAEVYDSEPFAEAVRAACDVVGW
                     TNDLYSLDKETALGEYHNLVTVVQHARGIGQTEAIGVVAERITRRLREYLAAEPLIRKR
                     HKEIEPYLAGLRSWMRGNLDWSASTRRYREALHDTENPASYLEPALIDRSAA"
     gene            complement(12030..13430)
                     /locus_tag="A4R43_RS09400"
                     /old_locus_tag="A4R43_09320"
     CDS             complement(12030..13430)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="A4R43_RS09400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09320"
                     /product="cytochrome P450"
                     /protein_id="WP_113691967.1"
                     /sec_met_domain="p450 (E-value: 6e-89, bitscore: 297.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNQAVDDRRARGAETGSARPVPRPSLRDEVRSTFAMRRDQVGFL
                     NQMIGRYGDIVQIRVLGIKMAMLNHPDYFEHVLVRNHENYNKDTFLFRAIAPILRGGLI
                     GNVGGEPWRHQRRTMQPSFHRPQVAGFALNMTDETAQMLDRWDRQYGPSDVVNVSTELG
                     QLAMRIVFRSLFGAKVGARGKAIEDMFFEANQIACAFFRFPLIPLTWPTPSHRRLAEII
                     RTMDGFVADIIADRVRSGEQHDDLLDAMLHAVDDVTGTGLSEQQLHREVLNLIIGGYET
                     TSNSVSWLMHTVGQHPEVQQRLLDEVDTVLNGRAPTFDDVLNLKYTRMIVDETLRLYTP
                     AWQTMRSSIEEDVIGGFRIPAKSDLYLNIYALHRHPEFWPDPETFDPDRFTPDEVAKRP
                     KQAYIPFGSGPRICIGKHFALTELVIILAMIAQRYRVVIPPGCGNVQPEPLITLHPKGG
                     VHVRVVRR"
     misc_feature    13477..13491
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.82"
                     /tool="antismash"
     gene            13589..14005
                     /locus_tag="A4R43_RS09405"
                     /old_locus_tag="A4R43_09325"
     CDS             13589..14005
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019013.4"
                     /locus_tag="A4R43_RS09405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09325"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_113691968.1"
                     /sec_met_domain="PF07366 (E-value: 1.1e-12, bitscore: 46.8,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIELAERWATAFNNHDAAAFVACYAETGILEDKALRRTFRGRGE
                     LAVFFEEWCAASPESQVDLDRVLPTESGLVVTWTGRGVLSGHFPHLPPTAVRGSRIELP
                     AISVLDLDRDGLIVSHTDYYDALSLLQQIGVLAA"
     misc_feature    14036..14050
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            14039..15238
                     /locus_tag="A4R43_RS09410"
                     /old_locus_tag="A4R43_09330"
     CDS             14039..15238
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="A4R43_RS09410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09330"
                     /product="cytochrome P450"
                     /protein_id="WP_113691969.1"
                     /sec_met_domain="p450 (E-value: 9.5e-23, bitscore: 79.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLDRLGRDFLGNPCPVLAELRERDRIRRVVHHGVPGWLVTRFDD
                     LHAMYTEPRLSVNPRHAPDHVRAVPWVAAAEAMGLGQCLAVVDPPEHTRLRRLAHSAFT
                     PRQVERLRPRARVAAERLIGAAAERGRADIMADVALPLTIEMIMRLIGVPITDSQTFAE
                     NTYLFLSSDPADADRVPGAMAWLSAYIAGLVADKQAEPGDDLLSAFVTENDDDRLNATE
                     LAAMTLMLLVGGFNTVSGLIAAGLLTLLSHPDQLAALRAEPELIPGAVEEMLRYESTLG
                     SSLLRFATEDFTFAGARIRRGDVVMGSILAANRDPRRFAEPDRFDIRREPGRHLAFGRG
                     IHYCLGAPLARLEAQVAFTVLLERCGSIRLAVPAEDLRWRMMPTVRALEALPVVLSPAE
                     "
     gene            15299..16423
                     /locus_tag="A4R43_RS09415"
                     /old_locus_tag="A4R43_09335"
     CDS             15299..16423
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (30-313). E-value: 3e-50.
                     Score: 163.1. Matches aSDomain:
                     nrpspksdomains_A4R43_RS09415_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017982788.1"
                     /locus_tag="A4R43_RS09415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09335"
                     /product="aminotransferase class III-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_113691970.1"
                     /sec_met_domain="Aminotran_3 (E-value: 7e-47, bitscore:
                     158.9, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFADRARRVLPGGNTRTTIFVPPHPPYAVSGEGAVLTDDTGHRV
                     IDGNNNYTSLIHGHAHPDVLAAAIEAAQRGTAFGLPTHAEVALAEHLRDRTGIEQWRFC
                     NSGSEAVLMLLRAARAHTGRDLVVRFEGSYHGTGDALVSPDAPGVAPSAVLVLPQHDLG
                     ALTAAMREHGDRVAAVLIDLMPNHAGLAPADPAYVEALRDLTRQHGALLAIDEIITFRL
                     HEGGLHRTYGIEPDLVAVGKVIGGGFPVGAIGGSAEVLAPFAPAAGAVSWGGTFNANPV
                     TMAAGLTALTLFGTAEIAALNQRGDELRSRLRAEGVAVNGSGSLLRLMTPDPTRLWWDL
                     YRRGVLIGTNGLLALSTAMTPDHLDQIAEAVTTS"
     aSDomain        15389..16237
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS09415_Aminotran_3.1"
                     /evalue="3.00E-50"
                     /label="A4R43_RS09415_Aminotran_3.1"
                     /locus_tag="A4R43_RS09415"
                     /protein_end="313"
                     /protein_start="30"
                     /score="163.1"
                     /tool="antismash"
                     /translation="SGEGAVLTDDTGHRVIDGNNNYTSLIHGHAHPDVLAAAIEAAQRG
                     TAFGLPTHAEVALAEHLRDRTGIEQWRFCNSGSEAVLMLLRAARAHTGRDLVVRFEGSY
                     HGTGDALVSPDAPGVAPSAVLVLPQHDLGALTAAMREHGDRVAAVLIDLMPNHAGLAPA
                     DPAYVEALRDLTRQHGALLAIDEIITFRLHEGGLHRTYGIEPDLVAVGKVIGGGFPVGA
                     IGGSAEVLAPFAPAAGAVSWGGTFNANPVTMAAGLTALTLFGTAEIAALNQRGDELRSR
                     LR"
     gene            complement(16420..16647)
                     /locus_tag="A4R43_RS09420"
                     /old_locus_tag="A4R43_09340"
     CDS             complement(16420..16647)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024950.4"
                     /locus_tag="A4R43_RS09420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09340"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_236808858.1"
                     /transl_table=11
                     /translation="MPGLSPGLTVTNTFKPLGADRQAAIYEELRRTVPLHRPGTTAEMA
                     KAAVYLASDESAYTVGTVLRVDGGIGELAY"
     gene            16738..17160
                     /locus_tag="A4R43_RS09425"
                     /old_locus_tag="A4R43_09345"
     CDS             16738..17160
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643916.1"
                     /locus_tag="A4R43_RS09425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09345"
                     /product="DUF6292 family protein"
                     /protein_id="WP_113691971.1"
                     /transl_table=11
                     /translation="MEHPEPDTRTLERALRQYVRAVAAAVGVPDESTTVEISDTATAYL
                     GLPLRWADRPGHDVMLVWNERRGWSLAVETDPAAAPILLAHHGGDVVPAPDAVARFVTD
                     TAAGHHPGQARPGPASTATRGSLAERLKPYVHDATG"
     gene            complement(17177..18376)
                     /locus_tag="A4R43_RS09430"
                     /old_locus_tag="A4R43_09350"
     CDS             complement(17177..18376)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013676948.1"
                     /locus_tag="A4R43_RS09430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09350"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_113691972.1"
                     /transl_table=11
                     /translation="MSGISVLVAGASIAGPALAHWLHRWGAEVTVVERASELRPGGQAV
                     DARGVAKEVIGRMGLDAAVRAACTDTAGAHTVDADGQVLQTFHAEDDGGDGFIADIEIL
                     RGDLSRVLYDDTRDSVEYLFGDRIAELTQDADGVGVTFAGGDRRRFDLVVGADGLHSAL
                     RAMVFGPHERFLHHLGHVLAFYSVPNEFGLDRWLLEYQEQESGRSALLRPIQDATRAMA
                     MFYFASPEFDVDYRDVAAQKVLLRERMAGLGWLTQDILAHLDDTPDFYLDQVAQVVMDR
                     WSNGRVGLLGDAAFSSSPMSGQGTGLALVGAYVLAGELAAAGWDPDAGFARYEARMRSF
                     VEANQEIGRLNARSRDVPGAEPPPDFTGEWFTELVGRAINGVELPDYAGVPDAEAVAPR
                     "
     gene            18971..19555
                     /locus_tag="A4R43_RS09435"
                     /old_locus_tag="A4R43_09355"
     CDS             18971..19555
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673908.1"
                     /locus_tag="A4R43_RS09435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09355"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_113691973.1"
                     /transl_table=11
                     /translation="MRKLTFAMNVSLDGYIAARGDDLGWSGGDGPDSSPGDELFRWWSD
                     RVAATGLALYGRKLWANMSSHWPTADQRPGATPAEKEFSRRWRDMPKVVFSSTTSTVDW
                     NTRLVTGDAVTEITRLKAEDGGPMDIGGATLAAAAMRAGLIDEYVLVTVPVLVGGGTPF
                     FTALDSWVNLNLVETRTFPGGVLLTRYQTRR"
     misc_feature    complement(18976..18989)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.92"
                     /tool="antismash"
     gene            complement(19578..20579)
                     /locus_tag="A4R43_RS09440"
                     /old_locus_tag="A4R43_09360"
     CDS             complement(19578..20579)
                     /EC_number="2.7.7.6"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646287.1"
                     /locus_tag="A4R43_RS09440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09360"
                     /product="RNA polymerase subunit sigma-70"
                     /protein_id="WP_113691974.1"
                     /transl_table=11
                     /translation="MTDASSLGADAATFIAVVRAGDKARFALITERHRRELQLHCYRML
                     ANYEDAQDMTQETFLRAWHKRESFKGNAAPRTWLYRIATNACLDFLEKRNDRTPVPSEL
                     ADSELPYLQPYPDRMLPEDPQESAVARETVELAFIVAVQYLPPRQRAVFILRDVLGWPA
                     SKAADALELTVASVTSALQRARVTMREQLPGRRLDWRGPATHELSNDERGVVKSYIGAH
                     ERNDLDGLISLLRDDLRFAMLPDSGTLVRTAKAAVDGWVSGGLFQPGHDDWRGIVTTVN
                     RMPAAALYLRTPGDPAYRLFAIAALRVVDGKIAELTGFDATGQPWLDLPPTV"
     gene            complement(20576..21436)
                     /locus_tag="A4R43_RS09445"
                     /old_locus_tag="A4R43_09365"
     CDS             complement(20576..21436)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005452909.1"
                     /locus_tag="A4R43_RS09445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_09365"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_113691975.1"
                     /transl_table=11
                     /translation="MTALLATGITVTFGSRTVLDGVGLAVPSGQWLALVGRNGCGKSTL
                     LRVLAGLHAPDAGSVSLDDRPLRTLSRRAVARRIAVLPQAMPPVPALTARQLVRQGRYA
                     TRGPLGMLAGGDDEQVERALADAGVEAYADAVLDRLSGGERQRVRLALALAQDAPLLLL
                     DEPTTYLDVHHQLQMLDLIDRLRAERGLTVVTVLHDLVQAARYADRIVALHDGRVHADG
                     PAAEVVTADLLEAVFGVHGRVWHDEVTGRPLCAYDRVSGSTDQKSSAAPSVLAAPSRRW
                     KDRRP"
ORIGIN
        1 cttgccgggc gcgagcgccg ccaccatcga caagaacacc acgtcgcgct cggacccctg
       61 gaagtccgcg gcatcgccac aacgcaggtc gcgagccctc cattcgtcct tcgggatccg
      121 gctgagcaac cgggtctgga tgtccttggc ctgtgctggg ccgagcaagg agatgacacc
      181 gaaggtcttg ccgtcgtagg ccgggtccgc gatgcacttc tcgatctggt cgacgatcgc
      241 ctcggcctcg acgggattca gcttgttggt cgttcctcgc tcatacccct cggggaggtg
      301 gaccgccttg accggctcca ggcggtctgc gccgtactgc cggaccggaa cgagccggat
      361 cccgtccggc tcgtaagcga tccggttgga gaacccgatg atctccggta cgcatcgccg
      421 gtgttcggtc agggtgatca ggttgccgta gcgcatcttg gcctcgtcga acaggctgcg
      481 cttggggtcg tgccaggaat cgcggtaccg atcgtccgcc agatattggc gtgcgaggtc
      541 tcgcaactgc tgctggtcga cccccacagc cgatggcgac acctgcttgt cgtcgccgat
      601 gaccacgatc ttcggcgcga ggtactgcag gaacaccgcc tcggtaccgg cctgcgaagc
      661 ctcgtcgacc acgacgacgt cgaacatgtc cggccgtacg cggagctgtt cggcgatccg
      721 gtagagcggc atgatccaca ccggtaccga tggccggcac cggtccatcg ccttccggat
      781 ctccaccctg cgctggttgc ggtagatccc cgtgttcttg cccgcccgct gcaccaactg
      841 ggcgtactgg gtcaggtcgg cgcgcgccgt accgctcagg cgctccggtg cggcggcgaa
      901 gtcccacgcg cggcgagcgg cgaccgattc gacgtgcgtg cggatgttct cttcgatatc
      961 cctgatccgc gcttgcaccg aattgacgtc gatcgattcc tggtgcagca cccacgtccg
     1021 cgtcgcggcc cagcaccacg cctcgtcgaa tcgcgccagc ctggacgtcc aaacctgctc
     1081 ccggccagcc tcgacgacgg cccgccgcag ttccggggcc accgcgttca gccgaccggc
     1141 gagttcttca cggcgctgga cgagccgtcg cacctcccac agcctctcca accgccagta
     1201 cgccgacgcg tacgcatcat gagcccggag cttgaccgcg tcgagcaact ccgcggtgca
     1261 cggggccgca tcggtccact gcgcggttcc tgcgatcagc tgctcgagtg ctgcgagtgg
     1321 tgccgtcgcc gaacgcctgg catcctcggc gcctgccgca tcggtcaact gcgcatagcg
     1381 gcggacgccg tccaggtcgt tccaatccgg cgcagggagc ttgagcaccc gcagccgttc
     1441 ctcctccgcg ccgagctcat cacccaatgc caacacgtgg cgcaactggt cgagctcggt
     1501 cacgtgccac tggagtcgtt cctgcggggt gtcctcggcg gggatggcaa cgttcgaggg
     1561 ccacgcccgg tccagggcgg acaacgcttt tgacgccccg atccaggcga ggaacgcgtc
     1621 cagctggtcc accgacgtgg gcggcaatcc gtcgacacgc accccgtcga acaacggctg
     1681 cgcctgcttg agcaccttgg gcgagaaggt cccgaccttc ggctggccgt ctggcagggt
     1741 cttgatggag ccgccgtccg ccaggtatcg ggacacctca cccgccagtg ccaccagcgg
     1801 cccgggttcc ccctggaatt ccacggaagc cagcggaccg agccgcgccg tgcacgcagc
     1861 gcactgcgcg acgagggttt gcaacgtgtc ggccctggcg cgccactggc cggctctccc
     1921 ggaacggaca tcccgcagtg cgtcgttcat ccactgctct cgtctggctg cgagccgatc
     1981 cgcctcatcg gcgagccggt gcaaccgctg ctgcaaccgc gtgcgttcgt ccgcggacag
     2041 catcagcacc gcgtcgaacg caacgtgcgc tttgagctga gcatgcctct gttcctcggc
     2101 ggtcgaaccg cgctccctca tcaccagcag ggcgaattcc tcgggtgcgg gcaccgcctc
     2161 gacctcgagc agccgcgtgc gtgcttcgac ctcatcggct cgaagccggt cgtcgagcag
     2221 gtagccgtgc cactcgaccg cttccgggct ggacaacggt gccgggtcgt cggcgccgac
     2281 cgccacgtga gccggcagcc agcggtgggc ctcggattcg gtgtccagct gtcgcgcgat
     2341 ggccgccagc gtgccgcggt agccgcggtg ttcgcgatgc cggacctcac gttccctggc
     2401 ttcgaccagc cggcggaagg aagccgcgcg ttcgcgcctc agccggtcga tctcaccgag
     2461 gtgggtacgg atggcttcgg cgttcgcctc cggatcgtgg tccaccgccg ccgccgcgat
     2521 ctcctggacg gcgagcttga ggtcagccat gtcttcacga gccgcaccca ccactgcgac
     2581 ggacagcggc ttgatcgggt caggcagctt ctcccggacc tcacggagcg cgcgatcggt
     2641 gtgcgcggtg accagcaccc gcttgccttg agcgaggagg tgggagatga gagccgctgc
     2701 cgtgtgcgtc ttaccggtgc cgggcgggcc ctgcaccagg gtctgagctt gtgcgtcaac
     2761 cctgcggatg atcgccagct gcttgtcgtt gaccggcatc ggcaggaagg gttcgtcgtc
     2821 gaccgcgacg atcgcgccct ccccgtccgg ccccggagct gtcggcttcc gatcgggatc
     2881 caccaggggc accaggccgt ccggcacttc acccgcatcg ccgagctggc ggaggatcgc
     2941 atcgaagatc tcgatcaggc cgctctccgt gcgccgccga aggatcagag ctggggccag
     3001 cgccgcgacg gcgtgcggta ccggcttgac gaattggtcc tgatctcggt attcgccgtc
     3061 agcatccagg ctgtgcacga ggcgtcgtac gagttcgccg accgcgtcgc ggtccagcgg
     3121 actgccttcg aacgcctcga catccgcacg gacctcgttg accttgtcgg gcgctgtgat
     3181 caggctcggg tccaccatgt ccaattcgag ccgcatgggt tcgccagctc cgacccggtg
     3241 cgcctcgatg gcgcccgtcc ggtcatcgaa gtgcacggtc gccggactgg tcagcacgtg
     3301 gcggatcacc ggttgctggt cctccgggag ccagctcaaa cagccgacgc cgacgaccaa
     3361 ctcgagctct tccggactat cggtggcact gatgtacgtc gaatacaggt cgctgtacaa
     3421 ctggcgcgcg ggagcgtcga ccaggtcctg gttggcccac tcctgccact tcggcaacca
     3481 caggcggaac tgctcctcga cctccggcga ttcctcgaga gtcaagaccc gcgactcggc
     3541 tgcctcctcg tcgccggtcc agcgaatccg ctggcgcagt gccgggggct ggtcgggctg
     3601 atcccacggc gcggtcagcc aacgggcgag ttcggccccc ggctcgggtg gctcaacctt
     3661 cggcaccctg tcgacgacga ccaggggttc atcgatcccc gtcagccccg tctgagccac
     3721 ccggaccgcc gggtgccgtg gtagctccgc gaaccagaac acagcaccat cacgctggta
     3781 ggtctcgacc gagcgcaccg gggtcgcctt gagccgctgc gcaccacgga ggaactcgaa
     3841 caaccgccgt gcgcggtcca ccaacgacgt acccatccca cccctgtccg acgatcacct
     3901 ggagatcagc accagcgctt gaaacgccac gcccctcctc catcgtcaca gttgaccaaa
     3961 cgtcacacag agttatcgaa tcgtgaactg cgtccgcagc accagaggtc cgaaagtagg
     4021 agctcgtgcc acaggacgga tcggttcgcg ggctccggac gtacgcgcta gcaagtcaag
     4081 cggtactggg tgctcgaccc acgagcttgg gcgcccaagt tcgccgaagc aggctgttct
     4141 ggggtatgac ctgatcaacc atcgccgcca attcacgtcg cccgcggtgc agcatcggca
     4201 acaccgctgg tatgggcgtc gagctgggga acggcatgtc ggcgaccagg tcccggaacc
     4261 cgaagtcgct ggccagccag cgagccaatg cacgaaggtg ttccgctgcc ctcgctctca
     4321 tgtcgatgcc acccagttcg atccggtagt cggtccggtc gatcccggcg gcccaagcga
     4381 gccccgagcg tcggaccagg cacgggaagc aatggccaca gttgggcggc gcttgggagt
     4441 agcgcgcact gctgggatcg ccacagctga ctgtgcgagc gagatcttcc ggtgagagcc
     4501 ctgcttccag ggcctggccg cacacctcac ccttggtgaa cgacagcagc ggattgacca
     4561 cctcgacagc gccgccgagc ccgcggatca ctcggttcgt cagctccagc gtccacgggt
     4621 ggaccgagcg ggtcgagagc ccagccaacc gattcggggt caacggcggg ttgatcgcga
     4681 gctgcccgtt ctccggagcg ttgacctgac cgaccccgtg cgccgatgca gccgctacgg
     4741 cggtcgccgt gtatagcagg ccccgcgtgc gcgtgctggg ttcgagctcg ccaccgggac
     4801 ccgaaagcac ccgttggccg atctgcacca gcttgaccgg ccggttccgg acccgatcga
     4861 cggaccgcca gacctcctgc tgccgggctc gcatgttgtc gtcgtacccc atgagcaaca
     4921 gcgttcccgc gtcatttccc tgcgccgaag cttgagctgc atacgaggtc gagtccaagc
     4981 ccccggagaa gagggctacc tccgaaacgc gctcttcgta gtcgaaccac tgccggtagg
     5041 cggcacctcc caccacgcga acctgccagg tatcgctggt cagcgtggcc aacaaggtgg
     5101 caaggtcctc cagttgcgcc gcaccccagc gttccggctc cgcgacttcg accgagaggt
     5161 cgaccgcgcg cgaccagccg tcttcagttc gccggacgta gcgcttgtcc accagataga
     5221 cggcacgcgc cacctgcagg aggtcgcgcg cccagggttc cgcgggcccg gccatcgtca
     5281 ttccttgatc aagacgagcc tcccgatcat ggaagtcagc gtcacacagc ggctcgcgat
     5341 cggaatccgt gcgatggcgg ccactcgcgg tgaacgcaaa gcgccgagcc acggcggtca
     5401 cgtgatcccc ccaggaagcc ccagcgccgc ggacaccgtg tcctgcaaca tgtcccgggc
     5461 gatttcggtg atggagcgag gatcgtcccg ttgcttttcc ttctcagcgc acggcatcgg
     5521 cagcaccgcg gcgacctggt cggcgaccca gtccgcgatc tgcccgctcg ggtccacgag
     5581 cacgagcgca ggaaccacga gcttcacctt ctcagctatg accgctcgca cgaatgcggc
     5641 cacgtaatcc gcgaaaaata gctggtagac ctcacaaaac aggctgtcgg cgaagttcca
     5701 gtcggaagtc tgccgctcaa tagcccctcg cgtcgccgga tcggcgagaa tcctctcggc
     5761 gcaggctgtg gcagagcgcc gtgcaagggc gtcggcgatc gtcgtacctt caccggctac
     5821 gacggaaacg aactggtaga gaaaccattc tcccggggtg cctgaccagc ccgagccgac
     5881 taccaggttc accggcccgc cgccgctgcc gaggccctcg accgcatcga tcagcgagcc
     5941 cccggctctc accattgtcg cgcggaggcc ataggcattc gggtcttcac gcaccgccgc
     6001 ggcgagtgcc tccaagcaac gccgtcctcg tttcgccgcc gactcgtccg aaatgggatg
     6061 atcctccggc tggcgcggcc cggggatgtc cgcagctgac gcggccagtc cctgggctgg
     6121 ccagatccgt gccacgcttc gggacacggt cttccactcg gccgtctgcg gcccggccca
     6181 tctgctcgaa gtacccacgc aagcgctccc cggtgccggc gactcctctc acgctacgca
     6241 cagatagtca cagcgcaata gccataggtg attccacctg ttcggcccag ccatgttggc
     6301 cgaggaatca gctgccatgc agtctccgtc gacctggtta cacccgaaag agatcgggcc
     6361 acccggtcgt gtttgaatgt gccgggatct caacgaactc gacacaaagc tcgggaggca
     6421 cgattcgcaa acgcgccaac caagggcaac ggcggagccg gggcgcaggt cgtgaagttc
     6481 cgcggtccga gccgaagcgc gaagcctcct cgtgaaccga ttctcgacct cgccgcacca
     6541 gcagagaaga ttgcggaacc acaagaaact tcgggaaatg gcacagaact cagtagcgac
     6601 aaacaggtgg cagccgcttg aagtgtactg gcccgccgaa gagttccttc gggataaaga
     6661 gaagctgatc ccggaaattg agagttgtta cgtacaagcg caccccagga acgcgcagcc
     6721 ttcgcccggg gacgtgacaa cctggcggga aagcgtctat cggctggcct cgctgctgga
     6781 ccacctccgc ctcggccgga tctggaggtt cgtggagtac cacgtcgatc cgaagatgag
     6841 ccctattgac gttgtcctct caggttttca cccggacggc ggcttgagcc ctcgacaagg
     6901 tctacttgga cgcatacgag aagcacaaaa agcaccccgc cgtgcaggtg cacgagaacc
     6961 tgctcgcact caaggtgcac cacagcatgt tcgatgaccg ttatgtgaac cttgtcggtg
     7021 cgtcatatct gcacaacttg aaggaaccag aataccaatg gatacggcac gtttcacctc
     7081 gcaacggcat accgacgttc acggtccgct cccccggtga gctggggaaa ttcctgagag
     7141 acaacttcag tgcgcagtcg ggtgccgacg ccgctgaagc actgctcgac cgacgtcgct
     7201 ccaactcctt gatcgagccg gaggtgggag cgatcgtagc ggggcacacg aagttcagct
     7261 tggtggagaa ccagctgacc gccgtgacga ccgtggcgga ggcgctggac agctgggcac
     7321 cggtcggcac gaagaaggtc ttcgtcgtca gcggccgagc tgggagcggc aagtcactga
     7381 tcgcattgac actgctcgga caggcactca atgccaggcg ggaagcctgc tacgtatcag
     7441 gggggatcgc gtcacgcgaa accttcaaac gcgcttccaa cgggcggcgg caagccttcg
     7501 ccaccctcaa caacatcgcc gacaaccggg cggcgaacga gctggacctg atcctgtgcg
     7561 acgaggcgca ccggctgacg gaacgcccga tgaagggctc ctactccatg cgacccggcg
     7621 aatcctcggt ctccgtggtc gtcacacggg cgaaggtgcc ggtcttcttc attgacggtg
     7681 accaacgtct gttttcggac gaggtctggt caccggaagc gctcaccagc gagctccacg
     7741 acctcggcac ggaggtcgtg ccgatcaccc tggaccgggt gctccgcgcc gtgggtagcg
     7801 cgacgtacga cacgtgggtc cagcacctgc tcgcaggcga cccactgccc tggaagccgg
     7861 atggcgggaa cgatcctgag ccgttccagc tctactactc cgacagcgcc gccaccatgg
     7921 agcgctttct ccgtgataag gagaacgagg gagaaagcgc tcggatcagc gccgggatct
     7981 gctggaagtg ggaagatcgc agcggcactg atccggaggt caacccggag ccgggttggg
     8041 cacgcccgtg gaacgccggc gaccagcaca acacacccgg cgtcccgaag cggcgattct
     8101 gggcgaccga acccggtggc ttcgggcaga tcggctgcgt gcacaccgcg cagggcctcg
     8161 agtacgagtg gggcggtgtg atcatgggcc ccgacctcac ctgggacggc ggtagctgga
     8221 aggtccaccg cgaacacgtg cggagcaagg ccaacaggat caatgcggac gaagacctcc
     8281 ggcgcgcgat ccgaaacgcc tacggggtgc tcatgactcg ttcgatccgc ggcacggtgc
     8341 tctactcggt cgattctgcc acgaggaagc tcttcgccga cctaggcgtc cacaagttgt
     8401 gaacacccac gcgatccgaa tgcatattcg tgtcatcaag ccctcttccc gagatagctc
     8461 ggtggtgcct ggtcatcttg accagccaac ggacctgctg ttgtgagcac gccacctcag
     8521 acgacttggt tcactcgcac aggaagaagt tcggcaggaa caggcgtgtg gttagtgcgc
     8581 acctcgcccc tcggacacac gcgttaaccc tacggggcgg gcggatggtc acctcgacca
     8641 tccgctcttt tgcgtagtac accatgtcca ggccgaacgc ctcgtagaac tgttggagct
     8701 tggccaggtg aacgcggttg agcttccggc tgacccggcg gtacgcgctg cctctggtgc
     8761 cgggccgaac cgatcgcccc tcggccgcgt ccgatagagg ctcgccgcgg gcggtgagcg
     8821 tcaacggctg tcgtacgccg cgcgggcggc gtcgatgtgg ggcaggtgcg tgatgctcca
     8881 ctcgagcagc ggcgcggtgg cctcccgcag ggtgcggccc atcgtggtca gctcgtagct
     8941 cacgtgcggc ggcatgacgt tgcggaccgt gcgcgtcagg atcccgtcgc gctcgagatc
     9001 ccgcagcgtc accgtgagca tgcgctgcct gatcccgtcg atggaccgct tgagctcggt
     9061 gaagcgccgc gggccgtcct tgagcatgcg cacgatcagc agcgcccact tgtccccgac
     9121 gatgccgagt acttcgcggg cctggcacgg gtcctgcatg gttacctcct gagaaccggg
     9181 gcacccgaaa gtgccgtatt gcccggtgcg cgccgggtgg accacgatgt ggtcggttac
     9241 caaaggatac cgaggcacga ggaggaacca cccgaccatg gccacctttc tgctggtaca
     9301 cggcgcctgg cacagcgggc ggagctggga ccgcgtggtc ccgctgctgg aatcggccgg
     9361 gcaccgggtg ctcgcgccgt cgctgaccgg ttacggcgac caggcacacc tgctgagccc
     9421 cgaagtcggg ctcggcaccc acgtggacga catcgtcggc ctgatcgaag ctgagcgtct
     9481 cgacgacgtc gtcctcgtcg ggcacagcta cgccgggatg gtcatctcgg gcgtcgccca
     9541 ccgggttccg gagcggatcg ctcacctggt gttcctggac gcgatggtgc ccgaagacgg
     9601 cgaagccgcg gtcgacgtcc atcccgtcac caagcagctc gtcgacctcg ccgtcgacgg
     9661 ctggcgggtc ccgccgatgc cggaacagcc gcccccgctc ggcctgttcg gcgtcaccga
     9721 ccccgaggac gtcgcctggt tgcgctcgat gctgtcggac cagccggtgc ggtgcctgct
     9781 cgaacccgcc cggctggaca acccggccgc gcgcacgatc ccgcgtacgc acatccactg
     9841 cctcgcggac cggccggcgg gcatcacccg gcgccctgtc ccggcaggcg agcgggtgcg
     9901 agaactgccc accggccacg actgcatgat caccatgccc gccgaactga ccgagttgct
     9961 ggtcgaagca gcccggtagg ccgcgggact gcggcggttc tcagtgatcg cggtcgagca
    10021 ggctgccggt cagcgcggcc aggccggcgc gagcggggcc gtcgaggtcc agcacatcga
    10081 tgaggtccca cgcggccgac acccggcgat cggcttccgc gcgggtccac tcgcgaccgc
    10141 ccgcttcctc gaccagttcg gtcaactgcg ccacctcggc gtcggtgagg gcttcgggtt
    10201 tggcgtagag cgaggcgatg cgcgcggacc cggcggtccc ggcggccagc gcggcggcca
    10261 ccggtgcgct cttcttgcgt gcccgcaggt ccgccccgac cggtttgccg gtgaccgccg
    10321 gatcgcccca gatgcccagc aggtcgtcgg ccagctggaa ggccacgccc aggtgcacgc
    10381 cgaaccgctc gaaccgcacc gcccattccg ccggcgcgcc cgagtgggcc acgccgagcc
    10441 ggcaggcgca gccgagcagc accccggtct tgccggtcat catcgccagg cactcgtcca
    10501 cggtcacccc ggtttcggac tcgaaccgca ggtccagttc ctgtccacgg gcgagcagcc
    10561 gcaaggtttt cgccagcagc gtcaccgaac gcgccgtcgc ggcgtgccgc tgggcggcga
    10621 gcacctcgaa gcccagcgcg atcagcgcgt caccggccaa tatcgcggtg gcttccccga
    10681 agcgtgccca cacggtcggc cggtgccgcc gttcgcgatc gccgtccatg atgtcgtcgt
    10741 ggatgagcga agcgttgtgc agcaactcga tcgcggcgcc cgacggcacc acgtcggccg
    10801 gtcgcgcacc ggtggccgcc ccgcacagca gcgcgaacgc cgggcgcagc agcttcccgc
    10861 tcaccccgcc ggtcggcctg cccgtgtcgt cgcacaggcc cagctggtag ccacagaccg
    10921 tggcgagttc cccgcccagc cggtcgatcc actcccccag caccggcggc agcaggcgcc
    10981 gggcgagcac cacacccgga ttgaccggcg cgctttcgaa cgcgggggcg ctcatgccgc
    11041 gctccggtcg atcagcgccg gttccaggta gctcgccggg ttttcggtgt cgtgcaacgc
    11101 ttcccggtag cgccgggtgc tcgccgacca gtccaggttg ccgcgcatcc acgaccgcag
    11161 gcccgcgagg tacggctcga tttccttgtg gcgcttgcgg atcagcggtt cggcggcgag
    11221 gtactcgcgc aaccgccgcg tgatccgctc cgcgaccaca ccgatcgcct cggtctggcc
    11281 gatccccctc gcgtgctgca ccacggtgac caggttgtgg tattcgccga gcgcggtctc
    11341 cttgtccagc gagtacaggt cgttcgtcca gcccaccacg tcacaggccg cgcgcaccgc
    11401 ctcggcgaac ggttcgctgt cgtacacctc ggccggcacg tccaggtgtt cggcgatctc
    11461 gatcaggtcg aagcagacgt agatcgcgcc ggtgtgccgc cgcttctcca cgtagtcggc
    11521 ctcaccggga atcgtgccgc tgacccggtt cgccgactcc cagcccgccg ccagcccacc
    11581 ggccaccacg tgctcgacga accgccgccg ccacgcctcg ctcgccgttt ccgtggtgcg
    11641 gtcccacagg tcggccagcg aagtcacgat cgacggcccc gccggatcgg cgccctttcc
    11701 ttccagcacg ccgaaaagcg caccgaggaa ctggtgcgtg cgctcgggat cgcggccgag
    11761 caccccgtcg tcgagctggt cgtcgagcag gaacaaccac gcgaaccagt cggcgaccag
    11821 gccgaggtcg cgttcgctcg ccgtcggata ggtgatcgcg gcgaaccagc cgaaggcagc
    11881 gcggtcgaac cgctccctcg ccgccgcgcg cccgatcagc ccctgctccc ccacccaccg
    11941 gttcaggtgc gcggtcgcgg cgtcggcgtg cggattgcac tccggggcga tggcctcgaa
    12001 cgcctcgacc atcctggtca ccgggccggt catcgccgga ccacccggac gtgcaccccg
    12061 cctttggggt gcagggtgat cagcggttcc ggctgcacgt tgccacagcc tggcgggatc
    12121 accacgcggt accgctgcgc gatcatcgcc aggatgatca ccagctcggt cagcgcgaag
    12181 tgcttgccga tgcagatgcg cgggccgctg ccgaacggga tgtaggcctg cttgggccgc
    12241 ttggcgacct cgtccggggt gaagcggtcc ggatcgaagg tctcgggatc cggccagaac
    12301 tccgggtgcc ggtgcagcgc gtagatgttg aggtacagat ccgacttcgc cgggatccgg
    12361 aagccgccga tcacgtcctc ctcgatcgag gaccgcatcg tctgccaggc cggcgtgtac
    12421 aaccgcagcg tctcgtcgac gatcatcctg gtgtacttga ggttcagcac gtcgtcgaag
    12481 gtcggcgcgc gtccattgag gacggtatcg acctcgtcga gcagccgctg ctgcacttcg
    12541 gggtgctgcc cgacggtatg catcagccag gacaccgagt tgctggtggt ctcgtagccg
    12601 ccgatgatca ggttgagcac ctcgcggtgc agctgctgct cggacaggcc ggtgccggtc
    12661 acgtcgtcga ccgcgtgcag catcgcgtcg agcaggtcgt cgtgctgctc cccgctgcgc
    12721 acccggtcgg cgatgatgtc ggcgacgaac ccgtccatcg tccggatgat ctcggccagc
    12781 ctgcggtgcg agggcgtcgg ccaggtcagc gggatcagcg ggaagcggaa gaacgcgcag
    12841 gcgatctggt tggcctcgaa gaacatgtct tcgatcgcct tgccgcgggc gccgaccttc
    12901 gcgccgaaca gcgagcggaa cacgatccgc atggccagct ggccgagttc ggtgctgacg
    12961 ttgaccacgt ccgacggccc gtactggcgg tcccagcgat ccagcatctg cgcggtttcg
    13021 tcggtcatgt tcaacgcgaa gccggccacc tgcggccggt ggaacgaggg ctgcatggtc
    13081 cgccgctggt gccgccacgg ctcaccgccg acgttgccga tcagcccgcc acgcaggatc
    13141 ggcgcgatcg cgcggaacag gaaggtgtcc ttgttgtagt tctcgtggtt gcgcaccagc
    13201 acgtgctcga agtagtcggg gtggttcagc atcgccatct tgatgcccag gaccctgatc
    13261 tgcacgatgt cgccgtaccg gccgatcatc tggttcagga aaccgacctg gtcccgccgc
    13321 atcgcgaagg tgctgcgcac ttcgtcgcgc aggctcggcc gcggtaccgg ccgcgccgaa
    13381 ccggtttccg cgccgcgcgc acggcgatca tcgactgcct ggttcgtcat ctgccccagc
    13441 ccctgccccg gtctcgtgtc ggataccggg aaccatactt ttcggcgaat tcgaagggtc
    13501 tccgatcctg cgctttgccg tttttgatgt tgttcggcat ccgcgcttcg gcgatcgtga
    13561 tctcattccc gattccagga ggaacccgat gaagatcgaa ttggccgaac gctgggccac
    13621 cgcgttcaac aaccacgacg cggccgcctt cgtggcctgt tacgcggaaa ccggaatcct
    13681 cgaggacaag gcgctgcgcc ggaccttccg cggtcgcggg gaactggccg tcttcttcga
    13741 ggaatggtgt gcggccagcc cggaaagcca ggtggacctg gaccgcgtac tgccgacgga
    13801 gtccggcctg gtggtcactt ggacgggtcg cggcgtcctt tcggggcatt tcccccacct
    13861 gccgccgacc gccgtccgcg gcagccgcat cgaattgccc gcgatcagcg tgctcgatct
    13921 cgatcgggac ggattgatcg tcagccacac cgactactac gacgcattga gccttttgca
    13981 gcaaatcggc gttctcgccg cctgatcatt tcgcgtcgac gtacccggag gcggcatcat
    14041 ggaccttgat cggcttggcc gggatttcct cggcaacccc tgcccggtgc tggcggaact
    14101 gcgggaacgg gaccggatcc ggcgggtggt gcaccacggc gtgccgggct ggctggtcac
    14161 ccggttcgac gacctccacg cgatgtacac cgagccgagg ctgtcggtga acccccgcca
    14221 cgcgcccgat cacgtgcgcg ccgtgccgtg ggtggcggcc gccgaagcga tggggctcgg
    14281 gcagtgcctc gccgtggtgg acccacccga gcacacgcga ctgcgccggc tcgcgcacag
    14341 cgcgttcacc ccgcgccagg tggaacggct gcgcccgcgg gcacgcgtgg ccgccgagcg
    14401 gctgatcggc gcggcggccg agcgcggccg cgccgacatc atggcggacg ttgcgctccc
    14461 gctgaccatc gagatgatca tgcggctgat cggcgtgccg atcaccgaca gccagacgtt
    14521 cgcggagaac acctacctgt tcctgtccag cgacccggcc gacgcggacc gggtgcccgg
    14581 cgcgatggcc tggctgtccg catacatcgc cggactggtg gccgacaagc aggccgagcc
    14641 cggtgacgac ctgctcagcg cgttcgtcac cgagaacgac gacgatcggc tcaacgccac
    14701 cgaactggcg gcgatgacgc tgatgctgct cgtcggcggg ttcaacaccg tgtccggcct
    14761 gatcgcggcc gggctgctga ccctgctgag ccacccggac cagctcgccg cgctgcgtgc
    14821 cgaaccggag ctgatccccg gcgcggtcga ggagatgctg cgctacgaat ccaccctcgg
    14881 ttcgagcctg ctgcggttcg ccaccgagga cttcaccttc gcgggcgcgc ggatccgccg
    14941 cggggacgtg gtgatgggct cgatactggc ggccaatcgc gatccgcggc ggttcgccga
    15001 acccgaccgg ttcgacatcc gccgcgagcc ggggcggcac ctggccttcg gccgcggcat
    15061 ccactactgc ctgggcgccc cgctggccag gttggaggcc caggtcgcgt tcaccgtgct
    15121 gctggaacgc tgtggcagta tccgtcttgc cgtccctgcc gaggatttgc gatggcggat
    15181 gatgccgacg gtacgtgcgc tggaggcgct gccggttgtg ttgagcccgg ccgaataggt
    15241 cgttatacac tcggcggggc accagcggct tcgtttcgcc gaacgtgagg agcgcgtcgt
    15301 ggacttcgcg gaccgggccc ggcgcgtgct gccgggcggc aacacccgga cgaccatatt
    15361 cgtcccgccc cacccgccct acgcggtcag cggcgaaggc gcggtcctca ccgacgacac
    15421 cggccaccgg gtcatcgacg gcaacaacaa ctacacctcg ctgatccacg gccacgccca
    15481 cccggacgtg ctcgccgcgg ccatcgaagc cgcccagcgc ggcaccgcgt tcggcctgcc
    15541 gacccacgcc gaagtcgcgc tcgccgagca cctgcgcgac cgcaccggga tcgagcagtg
    15601 gcggttctgc aactcgggct ccgaggccgt gctgatgctc ctgcgcgcgg cccgggcgca
    15661 caccggccgc gacctcgtcg tgcggttcga aggcagctac cacggcaccg gcgacgccct
    15721 cgtctccccc gatgcgccgg gtgtggcacc cagcgcggtg ctcgtcctgc cgcagcacga
    15781 cctcggcgcg ctcaccgccg cgatgcgaga gcacggggac cgggtcgccg cggtgctgat
    15841 cgacctcatg cccaaccacg ccggtctggc ccccgccgat cccgcctacg tcgaggcgct
    15901 tcgcgacctc acccggcagc acggcgcatt gctcgccatc gacgagatca tcacgttccg
    15961 cctgcacgaa ggcggactgc atcgcacgta cggcatcgag cccgatctcg tggccgtggg
    16021 caaggtgatc ggcggtggtt tccccgtcgg agcgatcggc ggcagcgccg aagtcctggc
    16081 gccgttcgcc ccggccgcgg gcgcggtgtc ctggggcggc accttcaacg ccaacccggt
    16141 cacgatggcc gccgggctca ccgcgctcac cctgttcggc accgcggaaa tcgccgcact
    16201 gaaccagcgc ggcgacgaac tgcggtcccg gcttcgcgcg gaaggcgtgg ccgtcaacgg
    16261 ctcaggctcc ctgctgcggc tgatgacgcc cgaccccacc cggctgtggt gggacctcta
    16321 ccggcgagga gtactgatcg ggaccaacgg cctgctcgcc ctgtccaccg ccatgacacc
    16381 ggaccacctc gaccagatcg ccgaagccgt caccaccagc tagtaggcaa gctccccgat
    16441 gccgccgtcc acgcgcagca cggtgccgac ggtgtaggcg gattcgtccg aggcgagata
    16501 gaccgccgcc ttcgccatct cggcggtggt tcccggccga tggaggggca cggtccgccg
    16561 gagttcctcg tagatggcgg cctggcggtc ggcgccgagc ggtttgaagg tgttggtgac
    16621 ggtcaggccc gggctcagtc caggcactgc tgcgcgagga ggccgtcact tcccggacct
    16681 gaccggggca cgcgcccgcc gggcacgctg accggcgggc cctctagcgt ggtgggggtg
    16741 gaacaccccg aacccgacac cagaaccctc gaacgcgccc tccgccagta cgtgcgggcg
    16801 gtcgcggccg cggtcggcgt tccggacgag agcaccacgg tggagatcag cgacaccgcc
    16861 accgcctacc tcggcctgcc cctccggtgg gccgaccggc ccggccacga cgtcatgctg
    16921 gtctggaacg aacggcgcgg ctggtcgctc gcggtggaaa ccgatcccgc cgcggccccc
    16981 atcctcctcg cccaccacgg cggcgacgtc gtgcccgccc cggacgcggt ggcgcggttc
    17041 gtcaccgaca ccgccgccgg gcaccacccc ggccaggcgc gtcccggccc ggcgagcacc
    17101 gcgacccgcg gatcgctggc cgaacggctg aagccctacg tccacgacgc gacaggctga
    17161 cctacttccc gaagcttcac cgaggagcga cagcctccgc gtccggcacc cccgcgtagt
    17221 cgggcagctc gacgccgttg atcgcgcgcc cgaccagctc ggtgaaccat tcgccggtga
    17281 aatcgggtgg cggctcggcg ccggggacgt cgcggctgcg ggcgttcagc ctgccgatct
    17341 cctggttggc ctcgacgaac gagcgcatcc gcgcctcgta gcgggcaaac ccggcgtcgg
    17401 gatcccagcc ggcggcggcc agttcaccgg ccagcacgta ggccccgacc agggccagcc
    17461 cggtgccctg cccggacatc ggcgacgagc tgaacgccgc gtccccgagc agtcccaccc
    17521 gtccgttcga ccagcggtcc atcaccacct gggcgacctg gtcgaggtag aagtccgggg
    17581 tgtcgtccag gtgcgcgagg atgtcctggg tcaaccagcc caagcccgcc atccgctcgc
    17641 gcagcagaac cttctgggcc gcgacgtcac ggtagtccac atcgaactca ggcgaggcga
    17701 agtagaacat cgccatcgcc cgggtggcgt cctggatggg ccgcaggagt gccgagcgcc
    17761 cggactcctg ctcctggtat tcgagcagcc agcgatccag cccgaactcg ttgggcacgc
    17821 tgtagaaggc cagcacgtgc ccgaggtggt ggaggaaccg ctcatgcggc ccgaagacca
    17881 tcgcccgcag tgccgagtgc agcccgtcgg ccccgaccac caggtcgaag cgccgccggt
    17941 cgccgcccgc gaaggtcacg ccgaccccgt ccgcgtcctg ggtgagttcg gcgatccggt
    18001 cgccgaagag gtactcgacg ctgtcgcggg tgtcgtcgta gagcacccgc gacaggtccc
    18061 cgcgcaggat ctcgatgtcg gcgatgaacc cgtcaccacc gtcgtcctcg gcgtggaagg
    18121 tttgcagcac ctgcccgtcc gcgtccacgg tgtgcgcgcc ggcggtgtcc gtgcacgccg
    18181 cgcgcaccgc ggcgtccagc cccatgcgcc cgatgacctc cttggccacc ccgcgcgcat
    18241 ccaccgcctg cccgccggga cgcagctcgg acgctcgctc caccacggtt acctcggctc
    18301 cccaccggtg caaccagtgg gccagcgcgg gccccgcgat gctcgcccct gccaccagca
    18361 cactgatgcc gctcaccgcg ccccccccag attcgaccgc ctggatcgta ccgggtttgc
    18421 cgttaactag tgctcggcag gtagacgacc tgcccatcat cgggcacgag gtaaccataa
    18481 acccgttttc gaggtattcc ttcagcacga atcctggcgg ccgagtctcc cccgggatag
    18541 gcgaattcca gtgctccgat cggaattccg aaatcaatcc agtctgatcc gtcatcttcg
    18601 cgaacgacac cgacatcaca aacgatgggt ttccagcgac accaacgagg gcggcaccgg
    18661 ctgttgccgg taaggctcca ggctggaggt gccgtaccag tcagcgactc cgaccgccgg
    18721 ccccaacgcc gccagcgcac gatccaatcg gaagtcgtca ttcggaccga tctcgatcgc
    18781 cagctcgtac gaaggccgtt gtcatcctca ccgcggcgct cctcggcgtc accgcggttg
    18841 cctcagcgcc acgccgagcg actcagcact gccgcttgga gcgacttccc ggtgcacgcc
    18901 gggcaccgat caggtttcgg cgccgcggcc gtctgtatct gtgagagcga ctcacaggag
    18961 gctgaacgcc atgcggaaac tgacctttgc catgaacgtg tccctggacg gctacatcgc
    19021 cgcgcgcggg gatgaccttg gctggagcgg gggtgacgga ccggactcgt cgcccgggga
    19081 tgagctgttc cggtggtggt ccgaccgggt ggcggcgacg ggactggcgc tgtacgggcg
    19141 caagctgtgg gcgaacatga gctcccactg gccgaccgcc gaccagcggc ccggcgccac
    19201 cccggcggag aaggagttct cccgccgctg gcgtgacatg ccgaaggtgg tgttctcctc
    19261 gacgaccagc acggtcgact ggaacacccg cctggtcacc ggcgacgcgg tcaccgagat
    19321 cacccggctc aaggccgagg acggcggccc gatggacatc ggcggcgcga cgctcgccgc
    19381 ggcggccatg cgggccgggc tgatcgacga gtacgtgctg gtcaccgtgc cggtcctggt
    19441 gggcggcggc acgccgttct tcaccgccct ggacagctgg gtgaacctga acctggtgga
    19501 gacgcggacg ttccccggcg gcgtactgct gacccggtac cagacgaggc gatgagcgca
    19561 cctgccgccg gcggtgctca caccgtcggc ggcaggtcca gccacggctg gccggtggcg
    19621 tcgaatccgg tcagctcggc gatcttcccg tcgacgacgc gcagggccgc gatcgcgaac
    19681 agccggtacg ccgggtcgcc gggggtgcgc aggtacaacg cggcggcggg catgcggttg
    19741 accgtcgtga cgatgccgcg ccagtcgtcg tggccgggct ggaaaagtcc gccggagacc
    19801 cagccgtcca ccgcggcctt cgccgtcctg accaaggtgc ccgaatcggg cagcatcgcg
    19861 aagcgcaggt cgtcacgcag cagggagatc agcccgtcga ggtcgttgcg ctcgtgtgcc
    19921 ccgatgtacg acttcaccac cccgcgctcg tcgttcgaca gctcgtgggt ggcgggaccg
    19981 cgccagtcga gacgacggcc aggcagttgc tcgcgcatcg tcacgcgcgc ccgctgcagc
    20041 gcgctggtca ccgacgcgac ggtcagctcg agggcgtcgg cggccttcga cgccggccag
    20101 ccgaggacgt cgcgcaggat gaacaccgcc cgctgccgcg gcggcaggta ttggacggcg
    20161 acgatgaacg ccagctcgac cgtttcccgc gccaccgccg attcctgcgg gtcctcggga
    20221 agcatgcggt cgggatacgg ctgcaggtac ggcagctcgg agtccgccag ctcggacggc
    20281 acgggggtgc ggtcgttgcg cttttccagg aagtcgaggc aggcgttcgt cgcgatccgg
    20341 tacagccagg tccgcggcgc ggcgttgccc ttgaacgact cccgcttgtg ccacgcccgc
    20401 aggaacgtct cctgcgtcat gtcctgggcg tcctcgtagt tcgcgagcat ccggtagcag
    20461 tgcagctgca gctcacgccg gtggcgctcg gtgatgagcg cgaaccgcgc cttatcgccc
    20521 gcgcggacca ccgcgatgaa cgtggccgcg tcggcaccca gcgagctagc gtcggtcatg
    20581 gtcgtcgatc cttccaccgg cgtgaggggg ctgccagaac tgacggcgcg gcggaggatt
    20641 tctgatcggt ggagccgctg acgcgatcgt aggcgcagag cgggcggccg gtcacttcgt
    20701 cgtgccagac gcgcccgtgg acgccgaaga ccgcctcgag cagatcggcg gtgacgacct
    20761 cggcggcggg gccgtcggcg tgcacgcggc cgtcgtgcag tgccacgatc cggtcggcgt
    20821 agcgggcggc ctggacgagg tcgtgcagca cggtgaccac ggtcaggccg cgttcggcgc
    20881 gcagccggtc gatcaggtcg agcatctgca gctggtggtg cacgtcgaga taggtggtgg
    20941 gctcgtcgag caggagcagc ggcgcgtcct gggccagtgc gagcgcgagg cggacgcgtt
    21001 gccgttcccc gccggagagc cggtcgagca cggcgtcggc gtaggcctcg accccggcgt
    21061 cggccagtgc ccgttcgacc tgctcgtcgt cgcccccggc gagcatgccc agcggtccgc
    21121 gggtggcgta gcggccttgc cggacgagct ggcgcgcggt gagcgcgggc accggcggca
    21181 tcgcctgcgg cagtaccgcg atgcggcgcg cgacggcccg gcgcgaaagc gtgcgcagcg
    21241 gccggtcgtc cagtgacacc gaaccggcgt cgggcgcgtg cagcccggcg agcacgcgca
    21301 gcagggtgga tttgccgcag ccgttgcggc cgaccagcgc gagccactgc ccgctcggca
    21361 cggcgaggcc gaccccgtcc agcacggtcc ggctgccgaa ggtgacggtg atgccggtgg
    21421 cgagcagagc ggtcatgagc catctccgga ggtgagggcg gactggcggc gggccgcgcg
    21481 gacgagcacg accgcaccgg cgatcgcggt gatcgcgccg gtgggcacgc ccagcggctg
    21541 cccgccgagc gcggcgagtt cggtgagctg ctgggccgcg gcgtcggcgg cgcagacggt
    21601 ggccgcgccg atgagcgcgc tgccgggcac gagcaggcgg tggtcggcgc cgaaggcgag
    21661 ccgcgcggcg tgcggggcga gcagcccgac gaaggccagg gcgcccacgg tggcgatcgc
    21721 cgcggcggcg gccaccacgg ccagcagcag ggtcgcgctg cgccaccggg ccgggtcgag
    21781 cccgaccccg cgggcgtggt cgtcgtcgac cgcgagcacc ccgagcaccg gcgcggccag
    21841 cacggcggcc accagcaccg ggaccagcca cggcagcagc gcctgccagt gcgcccagcc
    21901 gcggccgttg agcgagccga ccagccactg caccatggcg gcggcgccct gtggccgggc
    21961 ggtcagcagg atcagcgtga tcccggtgag caccgcggag atcagcacgc cgagcaccga
    22021 cagccgcagc ggg
//
