LOCUS       NZ_CP015163            20384 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis albispora strain WP1 chromosome, complete genome.
ACCESSION   NZ_CP015163
VERSION     NZ_CP015163.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis albispora
  ORGANISM  Amycolatopsis albispora
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Complete genome sequence and analysis of deep-sea sediment isolate,
            Amycolatopsis sp. WP1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2016) Zhejiang University of Technology, College
            of Pharmaceutical Science, Chaowang Road No.18, Hangzhou 310014,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera assembler v. unspecified
            Genome Coverage                   :: 138.17X
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:57:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,537
            CDSs (total)                      :: 8,472
            Genes (coding)                    :: 8,394
            CDSs (with protein)               :: 8,394
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 26 of 78
            Pseudo Genes (incomplete)         :: 54 of 78
            Pseudo Genes (internal stop)      :: 6 of 78
            Pseudo Genes (multiple problems)  :: 7 of 78
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:20:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1848705
            Orig. end                         :: 1869089
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015163.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20384
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20384
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20384
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10384](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10384)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(8..460)
                     /locus_tag="A4R43_RS08615"
                     /old_locus_tag="A4R43_08530"
     CDS             complement(8..460)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS08615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_08530"
                     /product="hypothetical protein"
                     /protein_id="WP_113691834.1"
                     /transl_table=11
                     /translation="MGVLFDYFAAPSDEAAAATIDRDGGPGSPAPVFDTLPVKGVDPVV
                     QLGTLEAQLTGRAYADIVADPRSGRDLASRGGGERLVLTVTDSLAAALAAAPDERLAEV
                     AVPWSETEEFWGQGDPVALADFLRDFAALARRADQAGHRLYCWLSV"
     gene            complement(488..859)
                     /locus_tag="A4R43_RS08620"
                     /old_locus_tag="A4R43_08535"
     CDS             complement(488..859)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017984264.1"
                     /locus_tag="A4R43_RS08620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08535"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_162788376.1"
                     /transl_table=11
                     /translation="MIESTTTPEQACPIAPVVDVVFSRWTTPILWALHEFGRQRFVELE
                     RRISTITPKVLTQRLRQLERDGLVVRTYHPEVPPRVEYEISELGRSLAPLFAALSEWSV
                     HLPEVERARAAYDARGGRR"
     gene            951..1763
                     /locus_tag="A4R43_RS08625"
                     /old_locus_tag="A4R43_08540"
     CDS             951..1763
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228572.1"
                     /locus_tag="A4R43_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08540"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_113691835.1"
                     /transl_table=11
                     /translation="MIVVTGATGNVGRPLVRALADAGEQVVAVSRGRTATDAPPGVRTR
                     QADVLRPETLRPALDGASALFLLTPGGVELPEVAALARDAGIRRVVLLSSLGVATGRHS
                     PATETAVTGTSPEWTVLRPGGFHSNTFAWAEGVRSQRAVAAPFAEVALPTVDPGDIAEV
                     AAAALTRPGHHGRTYLLTGPAPITPRQQAAAIAHALGEPVRFHEQTRAEAREQLLGFMP
                     EPVAEATLDILGHPLPAEREVSPDIERVLGRPPRDFAGWAARNVVAFK"
     gene            1760..2587
                     /locus_tag="A4R43_RS08630"
                     /old_locus_tag="A4R43_08545"
     CDS             1760..2587
                     /EC_number="3.8.1.5"
                     /GO_function="GO:0018786 - haloalkane dehalogenase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (14-125). E-value:
                     3.3e-28. Score: 90.9. Matches aSDomain:
                     nrpspksdomains_A4R43_RS08630_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228180.1"
                     /locus_tag="A4R43_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08545"
                     /product="haloalkane dehalogenase"
                     /protein_id="WP_113691836.1"
                     /sec_met_domain="PF00561 (E-value: 2e-22, bitscore: 79.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-14, bitscore:
                     53.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEILFHRETGTGAPIVFLHGNPTSSHLWRHVLPAVGGPGRRLAP
                     DLIGMGESGKPPIDYSFDDHARHLDAWFDALHLDEVVLVGHDWGGALAFDWAARHPGRV
                     RGIAFTETIVKPMTWAEFPEAGRELFRTIKAPGAGEELMLDRNLFIESLSGLAEADFDA
                     YRRPYPTRESRLPLLHWARMMPLDGEPADVVARVERYDEWLATTPEVPKLLLTFQPGYG
                     TMLTPELIAWCAEHIAGLDIVAHDLVAGHHTPEDQPEAVAATITAWLDKHQLR"
     aSDomain        1802..2134
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS08630_Abhydrolase_1.1"
                     /evalue="3.30E-28"
                     /label="A4R43_RS08630_Abhydrolase_1.1"
                     /locus_tag="A4R43_RS08630"
                     /protein_end="125"
                     /protein_start="14"
                     /score="90.9"
                     /tool="antismash"
                     /translation="PIVFLHGNPTSSHLWRHVLPAVGGPGRRLAPDLIGMGESGKPPID
                     YSFDDHARHLDAWFDALHLDEVVLVGHDWGGALAFDWAARHPGRVRGIAFTETIVKPMT
                     WAEFPEA"
     gene            complement(2580..3008)
                     /locus_tag="A4R43_RS08635"
                     /old_locus_tag="A4R43_08550"
     CDS             complement(2580..3008)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033788.1"
                     /locus_tag="A4R43_RS08635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08550"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_236808847.1"
                     /transl_table=11
                     /translation="MHRGLRFSGGRLIVTGTGQVRLAPGGLVLMPLALGPSNVLVKRNT
                     ATRTTIRYPARGLGVLGMAETPPGPGAVRLLGRARAGLLAALHTPATTTDLAAALGVTP
                     SAVSHHLRVLLENGLVERERTGRTVHYALTPLGRSFLT"
     gene            complement(3188..4150)
                     /locus_tag="A4R43_RS08640"
                     /old_locus_tag="A4R43_08555"
     CDS             complement(3188..4150)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229214.1"
                     /locus_tag="A4R43_RS08640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08555"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_113691837.1"
                     /transl_table=11
                     /translation="MTWLAWRQFRLPLALLYVALAAIAAVLLFAGRNDDELLYRGGQFA
                     LYLLPAAIGAFWGVPLITRELEAGTHKLVWNQGVTRGRWLAVKLGLGAVAAALAAGLLS
                     AVVSWWAAPVDAMAGAPDSTVVARIDVAMFAARGITPVGYAVFAFVLGVAAGLVLRRTV
                     AAMAVTLVVFAAVQVVVPLVVRPHLLPVTEQAVALSAENIEGVRVDEHDGPIALRVVRP
                     AGAWVVSEETVDARGGVVGSLPELVRGCVPSAPRPGALPDFERSHACFAQLSELGYQQR
                     LRYQPAARFWPLQWLETALFLVGSGLLGWFCFRRLRHVS"
     gene            complement(4147..5022)
                     /locus_tag="A4R43_RS08645"
                     /old_locus_tag="A4R43_08560"
     CDS             complement(4147..5022)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229213.1"
                     /locus_tag="A4R43_RS08645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08560"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_113691838.1"
                     /transl_table=11
                     /translation="MTVLRARGLGKAYRGRPALEGCELDIPAGHVTGLVGPNGAGKSTL
                     LNLAAGLLEPSTGTIEVCGGVPGSGPEQLAKVGFVAQNAPVYPTLTVDEHLRLGAKLNP
                     RWDAALAAERIGRIGLDPAQRAGRLSAGHRAQLALTLGIAKRPELLLLDEPVAALDPLA
                     RREFLRDLMAAVAEHGLSVVLSSHLVSDLERVCDHLVVLVGGRVRLAGELDELLATHHR
                     LTGPRRDVGTLPADQEVISASHTERQTTVLVRTEAPVLDPVWTVGKPGLEDLVLAYLGA
                     PARPVLRVVR"
     gene            complement(5019..5411)
                     /locus_tag="A4R43_RS08650"
                     /old_locus_tag="A4R43_08565"
     CDS             complement(5019..5411)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005456150.1"
                     /locus_tag="A4R43_RS08650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08565"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_113691839.1"
                     /transl_table=11
                     /translation="MLEFHLDGRSGLSPYQQIVRQVRHALRLGLLAEGDQLPKVKDVVA
                     ALAINPNTVLKAYRELEHDGLVAARPGVGTFVTATLSGASPAALGPLRQDLRRWLAKAR
                     RAGLDDESIEALFADTFHAVSTEDIA"
     gene            complement(5468..6139)
                     /locus_tag="A4R43_RS08655"
     CDS             complement(5468..6139)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012318.4"
                     /locus_tag="A4R43_RS08655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trypsin-like serine protease"
                     /protein_id="WP_113691840.1"
                     /transl_table=11
                     /translation="MRSVTARVTALVPAALLGLSTPAQAIVDGEFTASAPWSARLYQDG
                     ADGYCTATVLGPEWILTARHCIGGNHQWGFRVGNVEHAKGTYVDAAPNGVTLHENADLA
                     LVKLAEPVQAPAVSLGDLDAVAEGDTVTIHGWGDTGSGQQSPRLKNAQLKVTDVAAADA
                     YDGRAINGERVNGVCGSGDSGGPMFTADGVQVGVLSTGNSTSCQYTHVGAYRDWISSVT
                     G"
     gene            6236..6892
                     /locus_tag="A4R43_RS08660"
                     /old_locus_tag="A4R43_08575"
     CDS             6236..6892
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672308.1"
                     /locus_tag="A4R43_RS08660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08575"
                     /product="cutinase family protein"
                     /protein_id="WP_113691841.1"
                     /transl_table=11
                     /translation="MTKRQKAAIALAGLLAATGLSVASGPVAQAEAPCEGTYTIVVGGT
                     GSRPWNDGFTGNIQQHVGYPTDIPNGASARAGVNELNRLLRDQRNLCPGQHAKAVGYSL
                     GAAVVHIWVTENWQTFGNVNAVLIADPKRQAPPGLNGGSVPFGGIVGYPLAGADRYFGN
                     VPVKSICHWDYVCDESAGIWTYPNNHMYNYPNDWNVDHHNDTAHEQWFNGAWHPW"
     gene            complement(6867..7469)
                     /locus_tag="A4R43_RS08665"
                     /old_locus_tag="A4R43_08580"
     CDS             complement(6867..7469)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024701.4"
                     /locus_tag="A4R43_RS08665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08580"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_113691842.1"
                     /transl_table=11
                     /translation="MAGRRGYHHGDLPAALVRTSFELLAEQGLPSFSVAQVARRLGIST
                     ASPYRHFRDRDHLLAAVATAAARELTEAVRAATDAAGADPADRFAAAGSAYLRFAVGRG
                     AGFDVIYAAELAALRDEELATAGRELMDLFTGLAEATGARSKPETLELVGNLIALAHGY
                     AALYRNGLFAAGRYRLEDLAAQAENGARALTRGATPR"
     gene            7543..8274
                     /locus_tag="A4R43_RS08670"
                     /old_locus_tag="A4R43_08585"
     CDS             7543..8274
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-170). E-value: 3.8e-13. Score:
                     41.7. Matches aSDomain:
                     nrpspksdomains_A4R43_RS08670_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644524.1"
                     /locus_tag="A4R43_RS08670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08585"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_113691843.1"
                     /sec_met_domain="adh_short (E-value: 7.5e-34, bitscore:
                     116.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDGKVVAITGASSGIGAAIAAVLAGRGAKVVLGARRAERLEALA
                     ARIIADGGDVAWTVTDVRRRADLHGLVDLARSRYGRLDVLVGNAGIMPVSPLDELRVDE
                     WDDMVDVNIKGILHGIGAALPVFRAQGAGQFVHIASTSGHRTVPGQAVYSGTKFAVRAI
                     SEGLRQEAGPDLRVTIVSPGITHTEFSRTMESPDLRARLVELRDRIAMPPEAVARAVAY
                     AIEQPADIDLNEVIIRPTAQA"
     aSDomain        7558..8052
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS08670_PKS_KR.1"
                     /evalue="3.80E-13"
                     /label="A4R43_RS08670_PKS_KR.1"
                     /locus_tag="A4R43_RS08670"
                     /protein_end="170"
                     /protein_start="5"
                     /score="41.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVAITGASSGIGAAIAAVLAGRGAKVVLGARRAERLEALAARIIA
                     DGGDVAWTVTDVRRRADLHGLVDLARSRYGRLDVLVGNAGIMPVSPLDELRVDEWDDMV
                     DVNIKGILHGIGAALPVFRAQGAGQFVHIASTSGHRTVPGQAVYSGTKFAVRAISEGLR
                     QE"
     CDS_motif       7567..7644
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R43_RS08670_0001"
                     /evalue="4.40E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="A4R43_RS08670"
                     /protein_end="34"
                     /protein_start="8"
                     /score="9.7"
                     /tool="antismash"
                     /translation="ITGASSGIGAAIAAVLAGRGAKVVLG"
     gene            complement(8265..8411)
                     /locus_tag="A4R43_RS43875"
     CDS             complement(8265..8411)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS43875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_236808848.1"
                     /transl_table=11
                     /translation="MSAAHALGYRPVGDYAATVREELRWLMASPHRFPDFDYTAEDAWL
                     AQA"
     gene            complement(8408..9232)
                     /locus_tag="A4R43_RS08675"
                     /old_locus_tag="A4R43_08590"
     CDS             complement(8408..9232)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS08675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_08590"
                     /product="reductase"
                     /protein_id="WP_236808849.1"
                     /transl_table=11
                     /translation="MRRALILGGTGCLGRAVARRLVADGWRVDVTGRDPGRMPPGLAAA
                     GVRFHQAGRGDPLGTGVDLLVDCTCFTAAHAEALLPLARHATSTVMISSKAVYRDDEGR
                     HANSAEAPRFAGPVTERQPTLPPGTMPYDSAEGYGPNKVAAERTLLDSGLPVTVLRPSK
                     VHGEGASPPREWYFVKRALDRRPAVLLARRGRGADQPSAAVNLAALVAVVADQPGARVL
                     NAADPDAPDGLAIARIVAAEAGHRWREVLLDDNAPPNSAAIRGIACRRSCST"
     gene            9351..10019
                     /locus_tag="A4R43_RS08680"
                     /old_locus_tag="A4R43_08595"
     CDS             9351..10019
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013810.4"
                     /locus_tag="A4R43_RS08680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08595"
                     /product="hypothetical protein"
                     /protein_id="WP_113691844.1"
                     /transl_table=11
                     /translation="MRLRIAATCLAALATLLGAAPSAAEPAGREPIVFVHGLFGSPANF
                     DTMSLRFRLSGYPASELVAFSYNSTGSLTTAANQLATTIQQTLAATGARKVDLVTHSLG
                     GLPSRWCVKFLGGTATVDDWISLGGPNQGGAPGTCPAPGTTACDQATQGSAFLAQLNGG
                     DPTPAPVAHTTFASPCDTVVDEDWTTLDGATHVDVGCVSHFDLVSDRGVFTGVRQAVTG
                     "
     gene            complement(10001..10384)
                     /locus_tag="A4R43_RS08685"
                     /old_locus_tag="A4R43_08600"
     CDS             complement(10001..10384)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020638472.1"
                     /locus_tag="A4R43_RS08685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08600"
                     /product="hypothetical protein"
                     /protein_id="WP_113691845.1"
                     /sec_met_domain="T1TS (E-value: 0.0027, bitscore: 16.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTSMEDAGRCLLSVAWNMRSSPTRDCPRAEAIRDHLRVVCRSTG
                     HAACAWARSHGPGSAEEYLPFLRLADLAYEIDTLLLLVSNRLVPDDERDLRRWKEIEKL
                     VARAELLAMRTAGFLRDAQPVTA"
     misc_feature    10597..10611
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            10729..10968
                     /locus_tag="A4R43_RS08690"
                     /old_locus_tag="A4R43_08605"
     CDS             10729..10968
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS08690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_08605"
                     /product="hypothetical protein"
                     /protein_id="WP_113691846.1"
                     /transl_table=11
                     /translation="MRGAPASGWRRRFGPAFVSTALADRAMWWSWQRCENGWAFEIAFR
                     HPAIRDEFTGQPRIKAALDDAIAAGATVSVTARG"
     gene            11046..12038
                     /locus_tag="A4R43_RS08695"
                     /old_locus_tag="A4R43_08610"
     CDS             11046..12038
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS08695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_08610"
                     /product="hypothetical protein"
                     /protein_id="WP_113691847.1"
                     /transl_table=11
                     /translation="MIEMLRRWPVWVGRAAAGWAVLNAAVAGYWAAGGERGYLFEGRAG
                     ARLPTAAEVLIVVLSLAGALAALRPGRWARLPLLGLCGVAFLGTFGLAIGAVGAIAAGA
                     VPSPLALLYQLFCLAGAVTAVGTYLTWTRRRRGLCVRCGAPGHVPSPGPLVRPAPTSAA
                     WPVRVVAYLGICGFLPWAAVKIVLGFGGAALGATGDEWAATFTHTAMSPLTRWLHSFGI
                     DITVAAALVGALFLAALVHRWGFRLPRWLLLGVAWIGAPSLATYGLGLMIAGGLMLTGV
                     LAPPEVRPFSELGAAWVTLLGGLAFGPLGLGFLVGAVSHGRRSRPHCAR"
     gene            12081..14939
                     /locus_tag="A4R43_RS08700"
                     /old_locus_tag="A4R43_08615"
     CDS             12081..14939
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R43_RS08700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R43_08615"
                     /product="hypothetical protein"
                     /protein_id="WP_113691848.1"
                     /transl_table=11
                     /translation="MSVQLAFGVTAGAGVCCWLPTPGGRTLPKPASDRTGAHPPGAPVA
                     IGPADATPEALREAMRRLTLLVGDGTVTAAAAGVDLGGGFTSRRLAGAPGDRRDAVLAA
                     LKVLGAEGAHRLGDRTATLVALFGPSATKRVGAAASTAIAERRWAALQLASAASDLLGP
                     EQLEHVLALNAPDGIDPFPRGAASTLAEQLTLVLTRYPGPRRLTLVTSLWHHVCAHLVQ
                     RQRVKRRAAGQVRADRIGKLRERHREHLDAPLLQRLTWAAGGQASLADAARWQPPPEWP
                     ARELTWLLHDAIAATALLRFARTMSDEGLARAAEQHRAELAAADECLTEEQRTAATRRP
                     EGAYSHPARPGRYVHDLLKPLRPGRTITAKTETYVKERVAMARNYGVVVFDAVAELIRN
                     LDERPLHNCWDTCKPWQVSQLNRWRAVVGFFRAAGTWEQPPLADAHPDGPARALAARLT
                     PGADPATVEAPHDLLWYADLADALAPFYGNESATVRHARPAPDLDYETAAPPPEHPEAD
                     SVPLAAAGVAQLVAFGATPPPRCGSWAQLVDAVSADAAVTEASVGTFPIPPEISTVDKQ
                     VVPGTTLTVELGRDPRQLATWSGYMGNCIGETWYADQARRGHCVLMALRDPADHRIAAN
                     LDIRRHTGGWQIYELRARFNDTLAPALEKHIKRWVSELPGPVPPAPEPLLPVPPPRSRS
                     SRRRVAGRLPAALVDSLVAAVERELTAAPATSARRVYAQLARGLGPAGQPADFEPDAAV
                     IALKRLSPARHAELLRTALDTGLGAAALWQATRVRPLATAVNRLDHAELGALATAAPLP
                     RTLRALVRQAEIAPAHAMDVVSRAVRAAMGEPALADALARSAARRPSPELVCALVIART
                     TGSTMDNTVRVVPAGGTAVPGFPATDLFDADGPWQHALPAAADLGAPVDLFGERVAEHG
                     LLVPAALLGNGGWAALWSRAHR"
     gene            complement(14936..15742)
                     /locus_tag="A4R43_RS08705"
                     /old_locus_tag="A4R43_08620"
     CDS             complement(14936..15742)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009078515.1"
                     /locus_tag="A4R43_RS08705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08620"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_113691849.1"
                     /transl_table=11
                     /translation="MALRQVADGVLVHQSELIQNNTVVVRGRSGVLLIDAGIRGEEMAC
                     LANDLRELGQPVVAGFATHPDWDHVLWHPDLGDAPRYGTARCAAYLRELRSNPGWRDRV
                     ATGLPPEIEDEVPLELYGLITGLPAGTDRVPWDGPAVRIVEHPAHAPGHAALLIEERGV
                     LAAGDMLSDLLVPMFDDTTTAIEDYLTGLRVLEDAVADVEVVVPGHGSVGRGDEVRARI
                     QLDRAYVRALRDGREFDDPRIGASVKPGWEWVNDLHEGNTARFARS"
     misc_feature    15763..15775
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            15823..16320
                     /locus_tag="A4R43_RS08710"
                     /old_locus_tag="A4R43_08625"
     CDS             15823..16320
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018332797.1"
                     /locus_tag="A4R43_RS08710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08625"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_113691850.1"
                     /transl_table=11
                     /translation="MSAEAEPRSGCPINAAIEVFGDRWSLLVLRDIVFGDRRYFRELQA
                     GSMEGIASNILADRLKRLVESGLLTREDTRPGQRARYSLTEPAIQLVPVFAQLGSWGLR
                     HRPTSHSLRVRAELLEEGGPELWQEFMDELRREHLGVESAKSAPSVRERLNEAYFAAIK
                     SS"
     gene            complement(16331..16882)
                     /locus_tag="A4R43_RS08715"
                     /old_locus_tag="A4R43_08630"
     CDS             complement(16331..16882)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005456709.1"
                     /locus_tag="A4R43_RS08715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08630"
                     /product="NADAR family protein"
                     /protein_id="WP_236808850.1"
                     /transl_table=11
                     /translation="MTVLSREALVAAVAAGKRFEYFFFWGHTPGDAEVDKWCLSQWWPA
                     EFTVDGVRYRSAEQFMMAEKARLFGDAEAEKLILASETPAEAKKLGRAVREFDQETWVA
                     RRFDIVVRGNEAKFGQDERLREFLLSTGDQVLVEAAPRDVIWGIGLGAANPRAADPASW
                     RGRNLLGFALMAARDTLRAG"
     misc_feature    complement(16980..16994)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.27"
                     /tool="antismash"
     gene            complement(17036..17470)
                     /locus_tag="A4R43_RS08720"
                     /old_locus_tag="A4R43_08635"
     CDS             complement(17036..17470)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010237640.1"
                     /locus_tag="A4R43_RS08720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08635"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_113697446.1"
                     /transl_table=11
                     /translation="MATEPLTLYLVKRLELAIRARMDEALRPKGLTTLQFTAMTALRQR
                     RGLSSAQLARRSFVTPQTMNEMVRWLVERGHVERTRDPANRRVLLLGLTESGERLLAEC
                     DPLVEAIEAELLAAIPAVQHPLLRQSLEFGYTALSRDDGH"
     gene            complement(17497..18966)
                     /locus_tag="A4R43_RS08725"
                     /old_locus_tag="A4R43_08640"
     CDS             complement(17497..18966)
                     /NRPS_PKS="Domain: AMP-binding (11-394). E-value: 7.1e-112.
                     Score: 365.9. Matches aSDomain:
                     nrpspksdomains_A4R43_RS08725_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011873829.1"
                     /locus_tag="A4R43_RS08725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08640"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_113691852.1"
                     /sec_met_domain="AMP-binding (E-value: 8.4e-114, bitscore:
                     379.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDEGLGSWPVRRARMTPDRTALVHGERTVSYARLAARSAGLAHG
                     LRSAGVRRGDRVAYLGPNHPAYLETLFATASLGAVFVPVNTRLAAPELAYVLDDAGVSV
                     LVHATASPPAVRERLEVGGSRYEDFAECGAEPPDEPVALGDPCLIMYTSGSTGRPKGAV
                     LSHGNLTWNCVNVLVESDLSGGEVALVAAPLFHTAALGMTCLPTLLKGGTAVLMESFDP
                     AAALELIARHRVTLLFGVPAMYDAMAAQPGWDSADLSSVRTLLCGGSPVPPSTVRRYLD
                     RGLAFVQGYGMTEAAPGVLVLDPAAARTKAGTAGVPSFFTDVRVVDPAGDEVPPGGRGE
                     IVVRGPNVMLGYWNRPEATDQAMSGGWLHSGDVASVDGDGYFTVVDRLKDMIISGGENI
                     SPAEVEAAACEHPDVELCAVIGAPDPKWGEVGRAVVVRRPGAGLTADELRAHLRARLAG
                     YKVPKYVEFRDELPRTGSGKIRKAELRAEYA"
     aSDomain        complement(17785..18933)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS08725_AMP-binding.1"
                     /evalue="7.10E-112"
                     /label="A4R43_RS08725_AMP-binding.1"
                     /locus_tag="A4R43_RS08725"
                     /protein_end="394"
                     /protein_start="11"
                     /score="365.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RRARMTPDRTALVHGERTVSYARLAARSAGLAHGLRSAGVRRGDR
                     VAYLGPNHPAYLETLFATASLGAVFVPVNTRLAAPELAYVLDDAGVSVLVHATASPPAV
                     RERLEVGGSRYEDFAECGAEPPDEPVALGDPCLIMYTSGSTGRPKGAVLSHGNLTWNCV
                     NVLVESDLSGGEVALVAAPLFHTAALGMTCLPTLLKGGTAVLMESFDPAAALELIARHR
                     VTLLFGVPAMYDAMAAQPGWDSADLSSVRTLLCGGSPVPPSTVRRYLDRGLAFVQGYGM
                     TEAAPGVLVLDPAAARTKAGTAGVPSFFTDVRVVDPAGDEVPPGGRGEIVVRGPNVMLG
                     YWNRPEATDQAMSGGWLHSGDVASVDGDGYFTVVDRLKDMIIS"
     CDS_motif       complement(17881..17967)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R43_RS08725_0002"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="A4R43_RS08725"
                     /protein_end="362"
                     /protein_start="333"
                     /score="33.0"
                     /tool="antismash"
                     /translation="PPGGRGEIVVRGPNVMLGYWNRPEATDQA"
     CDS_motif       complement(18469..18525)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R43_RS08725_0001"
                     /evalue="2.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="A4R43_RS08725"
                     /protein_end="166"
                     /protein_start="147"
                     /score="26.1"
                     /tool="antismash"
                     /translation="LIMYTSGSTGRPKGAVLSH"
     gene            complement(18966..19799)
                     /locus_tag="A4R43_RS08730"
                     /old_locus_tag="A4R43_08645"
     CDS             complement(18966..19799)
                     /EC_number="4.1.2.61"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (11-224). E-value: 3e-48. Score:
                     156.2. Matches aSDomain:
                     nrpspksdomains_A4R43_RS08730_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010232107.1"
                     /locus_tag="A4R43_RS08730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_08645"
                     /product="p-hydroxycinnamoyl CoA hydratase/lyase"
                     /protein_id="WP_113691853.1"
                     /transl_table=11
                     /translation="MSAAPWGENVLVDFEDGIAWVTLNRPEKRNAMNPALNDEMVRTLD
                     ALEGDPRCRVLVLTGAGDSFSAGMDLREYFREVDESGDAAVQIRVRRASAEWQWKRLST
                     WSKPTIAMVNGWCFGGAFTPLVACDLAIAAETARFGLSEVNWGIPPGGVVSRALAATVS
                     QRDALYFIMTGEPFDGRRAAEMRLVNEAVPSERLRERTGELAAKLASMNPVVLRAAKVG
                     YKLAQDMPWEQAEDYLYAKLEQSQFLDPEQGRQKGMSQFLDEKAFRPGLSAYRNG"
     aSDomain        complement(19128..19766)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS08730_ECH.1"
                     /evalue="3.00E-48"
                     /label="A4R43_RS08730_ECH.1"
                     /locus_tag="A4R43_RS08730"
                     /protein_end="224"
                     /protein_start="11"
                     /score="156.2"
                     /tool="antismash"
                     /translation="VDFEDGIAWVTLNRPEKRNAMNPALNDEMVRTLDALEGDPRCRVL
                     VLTGAGDSFSAGMDLREYFREVDESGDAAVQIRVRRASAEWQWKRLSTWSKPTIAMVNG
                     WCFGGAFTPLVACDLAIAAETARFGLSEVNWGIPPGGVVSRALAATVSQRDALYFIMTG
                     EPFDGRRAAEMRLVNEAVPSERLRERTGELAAKLASMNPVVLRAAKVGYK"
     misc_feature    complement(19818..19832)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.18"
                     /tool="antismash"
     misc_feature    19960..19975
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.76"
                     /tool="antismash"
ORIGIN
        1 cagcgggtca gacgctcagc cagcagtaga ggcgatggcc cgcctggtcg gcccggcggg
       61 cgagagccgc gaaatcacga aggaaatcgg ccagtgccac ggggtcgccc tgaccccaga
      121 actcctcggt ctcgctccac ggcacggcga cctcggccag ccgctcgtcc ggcgcggccg
      181 cgagggcggc cgccaacgag tccgtgacgg tcaggacgag gcgttcaccg ccgccgcggg
      241 acgccagatc gcgaccgctg cggggatccg cgacgatgtc ggcgtaggca cgaccggtca
      301 gctgcgcttc caacgtgccg agctggacca ccggatcgac gcccttcacc ggcaacgtgt
      361 cgaagaccgg agccggcgag ccagggccgc cgtcacgatc gatcgtggct gcggcggcct
      421 catcggacgg ggccgcgaag tagtcgaaaa gcacacccat ccggccatcg tgccaggacc
      481 cgccgagtca gcggcggccg ccacgcgcgt cgtaggcggc cctcgcgcgt tcgacctcgg
      541 gcaggtgcac cgaccactcc gacagcgcgg cgaacaacgg cgccaggctg cggcccagct
      601 cgctgatctc gtactccacc ctcggcggca cctccgggtg gtaggtgcgc accaccagcc
      661 cgtcgcgctc gagctggcgc agccgctggg tgagcacctt gggcgtgatc gtgctgatgc
      721 gccgctccag ctcgacgaac cgctgcctgc cgaactcgtg cagtgcccac aggatcggcg
      781 tggtccagcg gctgaacacc acgtcgacca ccggcgcgat cgggcaggcc tgctccggcg
      841 tggtggtgct ctcgatcaca aatccgccct ccacccaata ctttcctcta ggtacctact
      901 atatccacgc cggtagcttc ctcgtgccta gccgaacgaa ggagctgacc atgatcgtgg
      961 tgaccggagc gaccggcaac gtggggcgcc cgctggtgcg ggcgctggcc gacgcgggcg
     1021 agcaggtggt cgcggtgtca cgcggcagaa cggccacgga cgcaccacca ggagtgcgca
     1081 cccgccaggc cgacgtcctg cgaccggaga ccctgcggcc cgcgctcgac ggcgcctccg
     1141 cgttgttcct cctgaccccc ggcggcgtcg aactgcccga ggtcgccgcg ctggcgcggg
     1201 acgccgggat ccggcgcgtc gtgctgctgt cttcgctggg ggtagccacc ggacggcact
     1261 cccccgccac cgaaaccgcc gtcaccggca cgagtccgga atggacggtc ctgcgcccgg
     1321 gaggcttcca cagcaacacc ttcgcctggg ccgagggcgt gcgcagccag cgggcggtcg
     1381 ccgcgccctt cgccgaggtc gccctgccca ccgtcgaccc gggcgacatc gccgaggtcg
     1441 ccgccgcggc gctcacccgg ccgggccacc acggccggac ctacctgctc accggcccgg
     1501 caccgatcac gccccggcag caggccgccg ccatcgcgca cgcactcggc gaaccggtgc
     1561 gcttccacga gcagacccgc gccgaagccc gcgaacagct gctcgggttc atgcccgaac
     1621 ccgtcgccga ggccactttg gacattctcg gccacccgct gcccgccgag cgcgaggtca
     1681 gcccggacat cgaacgcgtg ctcggcaggc caccacgcga cttcgccggc tgggccgcgc
     1741 ggaacgtggt ggcgttcaaa tgagcgagat cctgttccac cgcgaaaccg gcaccggcgc
     1801 cccgatcgtg ttcctccacg gcaaccccac gtcgtcccac ctgtggcggc acgtgctgcc
     1861 cgcggtcggc ggcccggggc ggcggctggc ccccgacctg atcggcatgg gcgaatccgg
     1921 caagccgccc atcgactaca gcttcgacga ccacgcccgc cacctcgacg cctggttcga
     1981 cgcactgcac ctcgacgagg tggtgctcgt cggccacgac tggggtggcg cgctggcctt
     2041 cgactgggcc gcccgccacc cagggcgggt gcgcggcatc gccttcaccg agaccatcgt
     2101 caagccgatg acctgggccg aattccccga agccggccgc gaactgttcc gcaccatcaa
     2161 ggccccgggc gcgggcgagg aactgatgct cgaccggaac ctgttcatcg aaagcctgtc
     2221 cggcctcgcc gaagccgatt tcgacgccta ccgcaggccg tacccgaccc gcgaatcccg
     2281 tttgccgctg ctgcactggg cccggatgat gccgctggac ggcgagcctg ccgacgtcgt
     2341 cgcccgggtc gagcggtacg acgagtggct cgcgaccacc ccggaggtgc cgaagctgct
     2401 gctgaccttc cagcccggct acggcaccat gctcaccccg gagctgatcg cctggtgcgc
     2461 cgagcacatc gccgggctcg acatcgtcgc gcacgacctc gtcgccgggc accacacccc
     2521 ggaggaccag ccggaggcgg tcgccgccac catcacggcc tggctggaca agcaccagct
     2581 caggtgagga aggaccggcc cagcggcgtg agcgcgtagt gcaccgtgcg gccggtgcgc
     2641 tcgcgctcga ccagcccgtt ctccagcagg acccgcaggt ggtgcgacac cgcgctcggc
     2701 gtcaccccga gcgcggccgc caggtccgtg gtggtcgcgg gcgtgtgcaa ggcggccagc
     2761 agcccggcac gcgcccgccc cagcaggcgg accgcaccag ggcccggcgg ggtctcggcc
     2821 atgcccagca caccgaggcc ccgcgccggg taccggatcg tggtccgcgt ggccgtgttc
     2881 cgcttgacca gcacgttcga cggccccagc gccagcggca tgagcaccag gccgccgggc
     2941 gcgaggcgca cctgcccggt cccggtgacg atcaaccggc cacccgagaa ccgcaggccg
     3001 cggtgcaacc ctgccctgca cctcgacgcc accggctacg tcctgctgct caccgccgcc
     3061 gcgattggcg gcgtgctcac cgcgatcgga ctcagtctgg acgcaacaaa gcaccaggcg
     3121 ctcggctggg gactgatgcc actgggcgcg ctggcgggcg ggtgctcgcc ctgcccgcgc
     3181 tcaggcgtca ggacacgtga cgcaaccgcc ggaagcagaa ccagcccagc agccccgagc
     3241 ccaccaggaa caacgcggtt tccagccact gcaacggcca gaaccgcgcc gccggctggt
     3301 agcgcagccg ctgctggtag ccgagttcgg acagctgcgc gaagcacgcg tgactgcgtt
     3361 cgaaatcggg cagcgcaccc gggcgcggcg ccgacggcac gcaaccccgc accagctccg
     3421 gcagcgaacc gaccacgccg ccccgcgcgt ccacggtctc ctcggacacc acccacgccc
     3481 cagccgggcg caccacccgc agcgcgatgg ggccgtcgtg ctcgtcgacc cgcacccctt
     3541 cgatgttctc cgcgctcagc gccacggcct gctcggtcac cggcagcagg tgcgggcgca
     3601 ccaccagcgg caccaccacc tgcacggccg cgaaaaccac caaggtcacc gccatcgccg
     3661 ccaccgtccg gcgcagcacc aaccccgccg cgacgcccag cacgaacgcg aaaacggcat
     3721 aacccaccgg cgtgatcccg cgcgcggcga acatcgccac gtcgatgcgc gccacgacgg
     3781 tgctgtccgg cgccccggcc atggcatcga ccggcgccgc ccaccagctg accaccgcgc
     3841 tgagcaaccc cgccgccagc gccgccgcca ccgcgcccag ccccagcttg accgccagcc
     3901 accgcccccg cgtcacgccc tggttccaca ccagcttgtg cgtgcccgcc tccagttccc
     3961 gcgtgatcag cggaacgccc cagaacgcgc cgatcgccgc gggcagcagg tagagcgcga
     4021 actgcccgcc ccggtagagc agttcgtcgt cgttgcggcc cgcgaacagc aacaccgccg
     4081 cgatcgccgc gagcgcgacg tacagcagcg ccagcggcag gcggaactgg cgccaggcca
     4141 gccaggtcat cgcaccaccc gcaacaccgg tcgggcgggc gcgcccaggt acgccagcac
     4201 cagatcctcc aggcccggct tcccgaccgt ccacaccgga tcgagcaccg gcgcttcggt
     4261 ccgcaccagc accgtggtct ggcgctcggt gtggctggcc gagatgacct cctgatccgc
     4321 gggcagcgtg ccgacgtcac ggcgcgggcc ggtcagccgg tgatgcgtgg cgagcagttc
     4381 gtccagctcc ccggccagcc ggacccggcc gccgacgagc accaccaggt ggtcgcacac
     4441 ccgctccaga tccgagacca ggtgcgagga cagcaccacg ctgagcccgt gctcggccac
     4501 cgccgccatc aggtcgcgca ggaactcacg ccgcgccagc ggatcgagcg cggcgaccgg
     4561 ctcgtcgagc agcagcagct cgggccgctt cgcgatgccg agggtgagcg cgagctgcgc
     4621 ccggtgacca gcggacaacc gtcccgcccg ctgcgcggga tccagcccga tccggccgat
     4681 ccgctccgcg gccagcgcgg cgtcccagcg cgggttcagc ttcgcgccga ggcgcaggtg
     4741 ctcgtcaacg gtcagcgtcg ggtagaccgg cgcgttctgc gcgacgaacc cgaccttcgc
     4801 cagctgctcc ggcccgctgc ccggcacccc gccacacacc tcgatcgtgc cggtgctcgg
     4861 ctccagcagg cccgcggcga gattgagcag cgtggacttg cccgccccgt tcggcccgac
     4921 cagcccggtc acgtgcccgg ccgggatgtc cagctcgcac ccttccagcg ccgggcgccc
     4981 ccggtacgcc ttgccgagac cgcgcgcccg caacacggtc acgcgatgtc ctctgtggac
     5041 accgcgtgga aggtgtcggc gaacagggct tcgatgctct cgtcgtccag ccccgcccgc
     5101 cgcgccttgg ccagccagcg ccgcaggtcc tgccgcaacg ggcccagcgc ggcgggcgaa
     5161 gcgccggaca gcgtggccgt gacgaacgtg cccaccccgg gccgcgccgc gaccagcccg
     5221 tcgtgctcga gttcgcggta ggccttgagc accgtgttcg gattgatcgc cagcgccgcc
     5281 accacgtcct tgaccttcgg cagctggtca ccctcggcca gcaggcccag gcgcagcgcg
     5341 tgccggacct gccgcacgat ctgctggtac ggcgacagcc ccgaccggcc gtccaggtgg
     5401 aactccagca ccccgggcct ccattccgct agttacctag cacaatagcg gcagcgggcc
     5461 gggccgctca gccggtgacc gagctgatcc agtcccggta ggcgccgacg tgggtgtact
     5521 ggcagctggt gctgttgccg gtggacagca ccccgacctg gacgccgtcg gcggtgaaca
     5581 tcgggccacc ggaatccccg ctgccgcaca ccccgttgac gcgctcgccg ttgatcgcgc
     5641 ggccgtcgta ggcgtcggcc gcggccacgt cggtcacctt cagctgcgcg ttcttcagcc
     5701 gtggcgactg ctggccgcta ccggtgtcac cccagccgtg aatggtcacc gtgtccccct
     5761 cggccaccgc gtcgagatcg ccgagggaaa ccgcgggcgc ctgcaccggc tcggcgagtt
     5821 tcaccagcgc cagatcggca ttctcgtgca gggtcacccc gttcggagcg gcatcgacgt
     5881 aggtgccttt cgcgtgctcg acatttccga cgcggaaacc ccattggtga tttccgccga
     5941 tgcagtgccg tgcggtgaga atccactcgg gaccgagcac ggtggcggtg cagtaaccgt
     6001 cggcaccgtc ctggtaaagg cgagccgacc acggcgccga cgcggtgaac tcaccgtcga
     6061 cgatcgcctg tgcgggcgtg gaaaggccga gcagcgcggc cggaacgagc gcggtgaccc
     6121 gtgcggtgac agaacgcatg gacgccaacg ctaatggcgg tcacccggaa gcggcacctg
     6181 cgaaagtcgg gtcctgtttc atcaggaatt catcggtgct cgctactttc ggccgatgac
     6241 aaaaagacaa aaggcagcga tcgcgctggc cggcctgctc gcggcgacgg gactttccgt
     6301 ggcgagcggt ccggtcgcgc aggccgaagc cccgtgcgag ggcacttaca cgatcgtggt
     6361 cggcggcacc ggcagcaggc cgtggaacga cggtttcacc ggcaacatcc agcagcacgt
     6421 cggctacccg accgacatcc ccaacggcgc cagcgcgcgg gccggggtca acgagctgaa
     6481 ccggctgctg cgcgaccagc gcaacctctg ccccggccag cacgccaagg ccgtcgggta
     6541 ctcgctcggc gcggccgtgg tgcacatctg ggtgaccgag aactggcaga ccttcggcaa
     6601 cgtcaacgcc gtgctgatcg ccgaccccaa gcggcaggcc ccgcccggcc tcaacggcgg
     6661 cagcgtgccc ttcggcggta tcgtcggcta cccgctggcc ggcgccgacc ggtacttcgg
     6721 caacgtgccg gtgaagtcga tctgccactg ggactacgtc tgcgacgagt ccgccgggat
     6781 ctggacctat ccgaacaacc acatgtacaa ctacccgaac gactggaacg tcgaccacca
     6841 caacgacacc gcgcacgagc agtggttcaa cggggcgtgg cacccctggt gagtgcgcgc
     6901 gcgccgttct ccgcctgcgc ggccaggtcc tcgagccggt agcgcccggc ggcgaacagc
     6961 ccgttgcgat agagcgccgc gtaaccgtgc gcgagcgcga tgagattccc cacgagttca
     7021 agggtttccg gcttgctccg cgcgccggtc gcctccgcga gcccggtgaa caggtccatc
     7081 agctcccgcc cggccgtggc cagttcctcg tcccgcagcg cggccagttc cgccgcgtag
     7141 atgacgtcga acccggcgcc gcggccgacc gcgaaccgca ggtaggccga gcccgccgcg
     7201 gcgaaccggt cggcgggatc ggcaccggcg gcgtcggtcg cggcccggac ggcctcggtg
     7261 agttcgcggg ccgcggcggt ggcgaccgcg gcgagcaggt ggtcgcggtc gcggaagtgc
     7321 cggtagggcg aggccgtgct gatcccgagg cgccgggcga cctgcgccac ggaaaacgac
     7381 ggcagcccct gctcggcgag cagttcgaag ctggtgcgga ccagcgcggc gggcaggtca
     7441 ccgtggtggt acccgcgcct gccagccatc ccgcctcctt gaccgccatg tgatagccct
     7501 cgtacattag caagcgatag ggctatcaca tggaggattc gcatgctgga cggcaaagtt
     7561 gtggcgatca ccggcgcgag cagcggcatc ggagccgcga tcgcggcggt gctggccgga
     7621 cgcggcgcga aggtggtgct cggcgcgagg cgggccgaac gcctcgaagc actggcggcc
     7681 cgcatcatcg ccgacggcgg tgacgtggcc tggacggtga ccgacgtccg gagacgcgcc
     7741 gacctgcacg ggctcgtcga cctggcacgc agccgctacg ggcggctgga cgtgctcgtc
     7801 ggcaacgccg ggatcatgcc cgtctcaccg ctcgacgaac tgcgcgtcga cgagtgggac
     7861 gacatggtcg acgtcaacat caagggcatc ctgcacggga tcggcgcggc gctgccggtg
     7921 ttccgcgcgc agggggccgg gcagttcgtg cacatcgcct ccacgtccgg gcaccggacc
     7981 gtgccggggc aggcggtcta ctcgggcacc aagttcgcgg tgcgggccat ctccgagggc
     8041 ctgcgccagg aagccggccc cgacctgcgg gtgaccatcg tttcgccggg catcacgcac
     8101 accgagttct cccggacgat ggagagcccg gacctgcgcg cgcgactggt cgaactgcgg
     8161 gacaggatcg cgatgccccc ggaggcggtc gcccgtgctg tcgcctacgc catcgagcaa
     8221 ccggccgaca tcgacctcaa cgaggtgatc atccgcccca cggctcaggc ctgagcgagc
     8281 caggcgtcct cggccgtgta gtcgaaatcg gggaagcggt gtggtgacgc catgagccag
     8341 cgcagttcct cccgcacggt ggccgcgtag tcgccgacgg gccggtagcc gagtgcgtgc
     8401 gcggcgctca tgtcgagcac gatcggcggc acgcgatccc acggatggcg gccgagttcg
     8461 gcggcgcgtt gtcgtccagc agcacctccc gccagcggtg cccggcctcg gcggcgacga
     8521 tccgggcgat agcgagcccg tccggggcgt cggggtcggc ggcgttgagc acacgcgcgc
     8581 cgggctggtc cgccaccacg gcgaccagcg ccgcgaggtt caccgccgcc gacggctggt
     8641 cggcgccccg gccgcggcgg gccagcagca ccgcgggccg ccggtccagc gcgcgcttga
     8701 cgaagtacca ctcccgcggc ggcgacgcgc cttcgccgtg caccttcgac ggacgcagca
     8761 cggtcaccgg cagcccgctg tccagcagcg tccgctcggc ggcgaccttg ttgggcccgt
     8821 agccttccgc ggagtcgtag ggcatggtgc cgggcggcag cgtcggctgc cgctcggtga
     8881 ccggcccggc gaaccggggc gcctcggcgg agttcgcgtg gcggccctcg tcgtcgcggt
     8941 agacggcctt gctggagatc atcaccgtcg aggtcgcgtg gcgggccagc ggcagcaacg
     9001 cctccgcgtg cgcggcggtg aaacacgtgc agtcaacgag caaatccacg ccggtgccca
     9061 gcggatcacc gcgccccgcc tggtggaatc gaaccccggc cgccgccaac cccggcggca
     9121 tacgaccagg gtcccggccg gtgacgtcca cccgccagcc atcggccacc agccgccgcg
     9181 ccaccgcccg gccgagacaa ccggtaccgc cgaggatcag cgcccgcctc atcaccaccc
     9241 cccccccggc tcagcctagg gggtgcgccg gtggttttgc cgatgccgcg gcggtgggcg
     9301 cgcctgccac catcggccgc agcccgtcac agcgagcacc tggagcaccg atgcgcctac
     9361 gaatcgcggc gacctgcctg gccgcactgg ccaccctgct cggcgcggca ccgtcggcgg
     9421 ccgagcccgc cgggcgggag ccgatcgtgt tcgtgcacgg gttgttcggc tcgcccgcga
     9481 acttcgacac gatgtccctg cgcttccgcc tcagcggcta ccccgccagc gaactggtcg
     9541 ccttctccta caactccacc ggttccctca ccaccgcggc gaaccagctc gccaccacca
     9601 tccagcaaac cctcgccgcc accggtgcgc ggaaggtcga cctggtcacc cactcgctcg
     9661 gcggcctgcc gtcgcgctgg tgcgtcaagt tcctcggcgg cacggccacc gtggacgact
     9721 ggatctcact cggcggcccg aaccagggcg gcgcgcccgg cacctgcccc gcgcccggca
     9781 ccaccgcgtg cgaccaggcc acccagggct cggcgttcct ggcgcagctc aacggcggcg
     9841 accccacccc cgccccggtc gcccacacca ccttcgcctc gccctgcgac accgtggtcg
     9901 acgaagactg gaccactttg gacggtgcca cccacgtaga cgtcggctgc gtcagccatt
     9961 tcgacctggt ctccgaccgc ggcgtgttca ccggcgtccg tcaggcggtg accggctgag
    10021 cgtcccgcag gaagcccgcg gtgcgcatcg ccagcaactc ggcgcgcgcc accagcttct
    10081 cgatttcctt ccaccgccgc agatcgcgct cgtcgtcggg caccaggcgg ttggacacca
    10141 gcagcagcaa cgtgtcgatc tcgtaggcca gatccgccag ccgcaggaac ggcaggtact
    10201 cctccgccga accggggccg tgcgaacgag cccacgcgca ggcagcgtgc ccggtggacc
    10261 ggcacaccac gcggaggtgg tcgcggatcg cctccgcgcg cgggcagtcg cgggtgggac
    10321 tgctccgcat gttccaggcc accgacagca ggcagcgccc ggcgtcctcc atcgacgtgt
    10381 tcatcaccgc cgcagtgtcc gggagaagtc gatcaacgca cgcaccgaca cacctcaaca
    10441 ccagatcgag cgagcgtgac ggcatcggaa tgtgcggttc cggcgttcct cagttgccga
    10501 aacgtggggc cacttcgcgg cgtcggacgg gctgttcagc tcggccgggg tgagtaccga
    10561 agaccccggc agcaccgcgg ccagcaccgc caccagttca ggggcgtcga taaaggtcag
    10621 caccgccgag tcgcgtcccg cgcccggcag gcaactggcc gtccacggga attccggccg
    10681 gccgctgtta gcatgggctc catgctggat ccctgactgc gcatcgaagt gcgcggcgcg
    10741 ccggcgtccg gctggcgccg ccggttcggc ccggcctttg tcagcaccgc gctcgccgac
    10801 cgggcgatgt ggtggtcctg gcagcgatgt gaaaacggct gggcgttcga aatcgccttc
    10861 cgccacccag ccatccgcga cgagttcacc ggccagccca ggatcaaagc cgctctcgac
    10921 gacgccatcg cggccggagc gaccgtcagc gtgaccgccc gcggctgacc ggatcagccc
    10981 tgcgggggaa gcggctccca cccgagcggg aagatcaccc cggcacgacc gcccaggctg
    11041 gagccgtgat cgagatgctc cggcggtggc cggtttgggt gggacgggcg gcggcgggct
    11101 gggcggtgct caacgcggcg gtcgccgggt actgggcggc cggtggcgag cgcggttacc
    11161 tgttcgaagg acgtgccggc gcgcggctgc ccacggccgc cgaagtgctc atcgtggtgc
    11221 tgtcactcgc cggagcgctg gccgcgctac gacccggccg atgggcgcgg ctccccctcc
    11281 tcgggctatg cggcgtggcc ttcctcggca ccttcggact ggccatcggc gcggtcggcg
    11341 ccatcgccgc gggcgcggtg ccgagcccgc tcgcgttgct gtaccagctt ttctgcctgg
    11401 cgggcgcggt gacggcggtc ggcacctacc tgacgtggac ccggcgtcgc cgcgggctgt
    11461 gcgtgcgctg cggcgcgccg ggccatgtgc cgtcgccggg acctctcgtg cgaccggcac
    11521 ccacctccgc cgcctggccg gtccgcgttg tcgcctatct gggcatctgc ggtttcctgc
    11581 cgtgggccgc ggtgaagatc gtcctcgggt tcgggggtgc ggcgctcggt gccaccggcg
    11641 acgagtgggc ggcgacgttc acccacaccg cgatgtcccc gctgacccga tggctgcact
    11701 cgttcggcat cgacatcacc gtcgcggccg cgctcgtcgg cgcgctgttc ctggccgcgc
    11761 tggtgcaccg ctggggtttc cggctgccga ggtggctgct gctcggcgtc gcgtggatcg
    11821 gcgccccttc gctggccacc tacggcctcg gcctgatgat cgcgggcggc ctgatgctca
    11881 ccggtgtcct cgccccgccc gaggtgcggc cgttcagcga actgggcgcg gcctgggtca
    11941 ccctgctcgg cggtctcgcg ttcggcccgc tgggcctggg tttcctcgtc ggcgcggtgt
    12001 cccacggccg ccggtcacgg ccgcactgcg ctcggtaaaa acgcgcaaaa cctgttgccc
    12061 cgtacgggat catggagggc atgtccgttc agctggcgtt cggggtgacc gccggagcgg
    12121 gggtgtgctg ctggctcccc acccccggcg gccgaaccct gcccaaaccc gccagcgacc
    12181 ggaccggcgc ccacccgccc ggcgccccgg ttgccatcgg accggccgac gcgacgcccg
    12241 aagcgttgcg cgaagccatg cggcggctca ccttgctcgt cggcgacggg acggtgaccg
    12301 cggccgccgc gggcgtcgat ctcggcggcg gcttcacctc caggcggctg gccggcgccc
    12361 ccggtgatcg gcgcgacgcc gtgctcgccg cgctcaaggt cctcggcgcc gagggcgcgc
    12421 accgcctcgg cgaccggacc gccacgctgg tggcgttgtt cgggccctcc gcgaccaagc
    12481 gggtcggcgc cgccgcgagc accgcgatcg ccgaacgccg ctgggctgct ctgcaactgg
    12541 cctcggccgc ctcggatctg ctcgggcccg agcagctgga acacgtactc gccctgaacg
    12601 ctcccgacgg aatcgacccg tttccgcgcg gtgcggcctc cacgctggcc gaacagctga
    12661 ccctcgtgct cacgcgctat cccgggccgc ggcggctgac actggtcacc agcctctggc
    12721 accacgtgtg cgcgcacctg gtccagcggc agcgcgtgaa acggcgtgcc gcgggccagg
    12781 tccgcgccga ccggatcggc aagctccgcg aacgccaccg cgagcacctc gacgccccgc
    12841 tcctgcagcg gctgacctgg gcggcgggcg gtcaggcgtc gctggccgac gcggctcgct
    12901 ggcagccgcc gccggaatgg cccgcccgcg aactcacctg gctgctgcac gacgccatcg
    12961 ccgccaccgc gctactccgc ttcgccagga cgatgtccga cgaaggcctc gcgcgagccg
    13021 ccgagcagca ccgcgccgag ctggccgccg cggacgaatg cctcaccgaa gaacagcgga
    13081 ccgcggccac acgccgtccc gaaggcgcct acagccatcc cgcgcggccg ggccgctacg
    13141 tccacgacct gctcaagccg ctgcggccgg gacgcacgat caccgcgaaa accgagactt
    13201 acgtaaagga acgcgtcgcc atggcccgca actacggcgt ggtcgtcttc gacgcggtcg
    13261 ccgagctgat ccggaacctc gacgagcgcc cgctgcacaa ctgctgggac acctgcaaac
    13321 cgtggcaggt gtcccagctg aaccggtggc gtgccgtggt gggcttcttc cgcgcggcgg
    13381 gcacctggga acaaccgccg ctggccgacg cccatcccga cggcccggcg cgggcactgg
    13441 ccgcgcggct gacgcccggc gccgatcccg ccaccgtgga ggcaccccac gacctgctct
    13501 ggtacgccga cctcgccgac gcgctggcgc ccttctacgg caacgaatcc gccaccgtcc
    13561 gccatgcgcg gcccgcgccc gacctcgact acgagaccgc ggcacctcca ccggaacacc
    13621 ccgaggccga ctccgttccg ctggccgccg ccggcgtcgc gcagctggtc gcgttcggcg
    13681 cgacaccacc gccccgctgc ggcagctggg cacagctggt ggacgcggtc agcgcggacg
    13741 cggcggtcac cgaggccagc gttggcacct tcccgatccc gccggaaata tccactgtgg
    13801 acaagcaggt ggtgccgggc accacgctga ccgtcgaact gggccgcgac ccgcggcagc
    13861 tggccacctg gtccggctac atgggcaact gcatcggcga aacgtggtac gccgaccagg
    13921 cacggcgcgg ccactgcgtg ctgatggcgc tgcgcgaccc cgccgaccac cgcatcgccg
    13981 ccaatctcga catccggcgg cacaccggcg gctggcagat ctacgagctg cgcgcgcggt
    14041 tcaacgacac cctggcaccg gcgctggaaa agcacatcaa gcgctgggtg agcgaactcc
    14101 ccggccctgt cccgcccgca cccgaaccgc tgctgccggt gccgccgccc cggtcgcgct
    14161 cgtcccgtcg ccgggtggcg ggccgcctgc cggccgcgct cgtcgattcc ctggtcgcgg
    14221 cggtcgaacg ggaactcacc gcggcaccgg ccacctccgc gcgacgggtg tacgcccagc
    14281 tcgcacgcgg actcggtccc gccggtcaac cggccgactt cgagccggac gcggcggtga
    14341 tcgcgctcaa gcgcctcagc ccggcccggc acgccgaact gctccgcacc gcactggaca
    14401 ccgggctcgg cgcggccgcc ctgtggcagg ccacgcgtgt ccggcccctc gccacggcgg
    14461 tgaaccggct cgatcacgcc gaactcggcg cgctcgccac ggccgcaccg ctgcccagaa
    14521 cgctgcgcgc cctcgtgcgg caggcggaga tcgcgcccgc ccacgccatg gatgtggtgt
    14581 cccgggcggt ccgcgcggcc atgggcgaac cggctctcgc cgacgcgctc gcccgctcgg
    14641 cggcccgcag gccgtcaccg gaactggtgt gcgcgctggt gatcgcccgc actactgggt
    14701 ccacaatgga caacaccgtg cgcgtggtcc cggcgggtgg caccgcggta cccggctttc
    14761 ccgccaccga cctgttcgac gcagacggac cgtggcaaca cgcgctgccc gcggccgccg
    14821 acctcggtgc gccggtggac ctgttcgggg agcgcgtcgc cgaacacggt ctgctcgtcc
    14881 cggccgcgct actcggcaac ggcggctggg ccgcgctctg gagccgcgca caccgctagc
    14941 tccgggcgaa cctcgcggtg ttcccctcgt ggaggtcgtt gacccactcc cagcccggct
    15001 tgaccgacgc gccgatccgg gggtcatcga attcacggcc gtcccgcaac gcccgcacat
    15061 acgcccggtc cagctggatc cgcgcgcgga cctcgtcgcc ccggccgacg gacccgtgcc
    15121 cgggaacgac aacctcgacg tcagccaccg cgtcttcgag cacccgcagc ccggtcaggt
    15181 agtcctcgat cgcggtggtg gtgtcgtcga acatcgggac caggagatcg gagagcatgt
    15241 caccggcggc cagcaccccg cgttcctcga tcagcagcgc cgcgtggccg ggggcgtggg
    15301 ccgggtgctc gacgatccgg accgcggggc cgtcccaggg cacgcggtcg gtgccggcgg
    15361 gcaggccggt gatgaggccg tacagctcca gcggcacctc gtcctcgatc tccggcggca
    15421 atcccgtggc gacgcggtcc cgccagcccg ggttcgaccg cagttcccgc agataggccg
    15481 cacagcgggc cgtgccgtag cggggtgcgt caccgaggtc gggatgccag agcacgtggt
    15541 cccagtcggg atgcgtcgcg aaacccgcca cgacgggctg ccccagctcg cggaggtcgt
    15601 tcgcgaggca ggccatctcc tcgccccgga taccggcgtc gatgagcagg acgccgcttc
    15661 ggccccgcac gacaacggtg ttgttctgga tcaactcgct ctggtggacc agcacaccgt
    15721 ccgcgacctg tctcagcgcc atgcctcccc agcctcctcc gcttgtgatt tgcaaccgct
    15781 tgcgcagacg gtagtcccga gtggtggtag attgcaagca ctatgagtgc cgaagctgaa
    15841 ccgcgatcgg ggtgcccgat caacgccgcc atcgaggtgt tcggtgatcg ctggagcctg
    15901 ctggtgctcc gcgacatcgt cttcggggac cgccgctact tccgcgagct gcaggcggga
    15961 tcgatggagg gaatcgcctc gaacatcctc gccgaccggc tcaagcggct cgtcgagtcc
    16021 ggcctgctca cccgcgagga cacacgaccc ggccagcggg cgcgctacag cctcaccgaa
    16081 ccggcgatcc agctcgtgcc tgtgttcgcg cagctgggca gctggggact gcgccaccgg
    16141 ccgacgagcc actcgttgcg cgtgcgcgcc gaactgctcg aagaaggcgg ccccgagctc
    16201 tggcaggagt tcatggacga actgcggcgg gagcacctcg gcgtcgagag tgccaaaagc
    16261 gcgccgagcg ttcgcgagcg cctgaacgag gcctacttcg ccgcgatcaa atcctcgtaa
    16321 ccgcccggaa tcacccggcg cgcagcgtgt cccgggccgc catcagggcg aacccgagca
    16381 ggttgcgccc acgccaggac gcgggatcgg ccgcacgcgg gttcgccgcg cccagcccga
    16441 tcccccagat cacgtcccgc ggcgccgcct ccaccagcac ctggtcaccg gtggagagca
    16501 ggaactcccg caaccgctcg tcctgaccga acttcgcctc gttcccgcgc accacgatgt
    16561 cgaaccggcg cgccacccac gtctcctggt cgaactcacg caccgcgcgg cccagcttct
    16621 tcgcctccgc cggggtttcg ctggccagga tcagcttctc cgcctcggcg tcaccgaaca
    16681 ggcgggcctt ctccgccatc atgaactgct ccgccgagcg gtacctgaca ccgtccacag
    16741 tgaactccgc gggccaccac tggctcaggc accacttgtc cacctcggcg tcaccgggcg
    16801 tgtgccccca gaagaagaag tactcgaacc gcttccccgc cgccacggcg gccaccagcg
    16861 cttccctcga caacacagtc acggcacgca ccctaacgac cggcaccgac atttccgccc
    16921 gcccgaccct cgcgccgtca ccccgacgca atgaatggct ttcattgcgc cagacgctat
    16981 gaaagccaca ttcattgcac ggcacggcag gcaggcgggt agctcgagcg acgggttagt
    17041 ggccgtcgtc gcggctgagg gcggtgtagc cgaattccag gctctgccgc agcagcgggt
    17101 gctgcacggc cgggatcgcc gcgagcagtt cggcttcgat ggcctcgacc agcggatcgc
    17161 attcagccaa caggcgctcc cccgactcgg tcagccccag cagcagcacc cgccggttcg
    17221 ccgggtcacg cgtgcgctcg acgtgcccgc gctcgaccag ccaccgcacc atctcgttca
    17281 tcgtctgcgg ggtgacgaac gagcgccgtg ccagctgggc cgaggacagg ccccggcgct
    17341 gccgcaacgc ggtcatcgcg gtgaactgga gcgtggtcag gcccttcggc cgcagcgcct
    17401 cgtccatccg cgcgcggatc gccagctcca gccgcttgac caggtagagg gtgagcggtt
    17461 cggtcgccat gtgctgatcg tgccccagcg ccgcgctcat gcgtactcgg cccggagttc
    17521 ggccttgcgg atcttgccgg aaccggtgcg cggcagctcg tcgcggaact cgacgtactt
    17581 gggcaccttg tacccggcga gccgggcacg caggtgggcg cgcagttcgt ccgcggtcag
    17641 cccggcgccg ggccgccgca ccaccaccgc gcgcccgacc tcgccccact tcgggtcggg
    17701 cgcgccgatc accgcgcaca gctcgacgtc cgggtgttcg caggcggcgg cctccacctc
    17761 ggcgggcgag atgttctcac caccggagat gatcatgtcc ttgagccggt cgaccacggt
    17821 gaagtagccg tcaccgtcca cactggccac atcgccggag tgcagccagc cgccggacat
    17881 cgcctggtcg gtggcctcgg gccggttcca gtagccgagc atgacgttcg ggccgcgcac
    17941 cacgatctcc ccgcgcccgc ccggcggcac ctcgtccccg gccgggtcga ccacacgcac
    18001 gtcggtgaag aacgacggta ccccggccgt gcccgccttc gtgcgcgccg ccgccgggtc
    18061 gagcaccagc accccgggcg ccgcctcggt catgccgtaa ccctgcacga aggccagccc
    18121 acgatcgagg taacgccgga cggtcgaggg cggcaccggc gacccgccgc acagcagggt
    18181 gcgcacgctc gagaggtcgg ccgagtccca gccgggctgc gcggccatcg cgtcgtacat
    18241 cgcgggcacg ccgaacagca gcgtgacccg gtgccgggcg atcagctcga gcgccgcagc
    18301 ggggtcgaac gactccatca gcaccgcggt cccgcctttg agcagcgtcg gcaggcaggt
    18361 catgcccagc gcggcggtgt ggaacaacgg cgccgccacc agcgcgacct cgccaccgga
    18421 caggtcggac tccaccagca cgttgacgca gttccaggtg aggttgccgt gggagagcac
    18481 cgcgcccttc ggccgcccgg tgctgccgga ggtgtacatg atcaggcacg gatcacctag
    18541 cgcgaccggt tcgtccggcg gttccgcgcc gcactccgcg aaatcctcgt accggctccc
    18601 gccgacctcc aggcgttccc gcaccgccgg cggcgacgcc gtggcgtgca ccaaaaccga
    18661 aaccccggcg tcgtcgagca cgtaggccag ttccggcgcc gccagcctgg tgttgaccgg
    18721 cacaaaaacc gcgcccagcg aggcggtggc gaacagggtt tccaggtagg cggggtggtt
    18781 cgggccgaga taggcgaccc ggtcaccccg ccgcacgccg gccgagcgca ggccgtgcgc
    18841 cagcccggcc gaccgggccg ccagccgcgc gtagctcacc gtccgctcgc cgtgcaccag
    18901 cgcggtccgg tccggcgtca tccgcgctcg ccgcaccggc cacgagccga ggccctcgtc
    18961 ccgcatcagc cgttccggta ggccgagaga ccggggcgga aggccttctc gtcgaggaac
    19021 tggctcatgc ccttctgccg tccctgctcc gggtcgagga actgcgactg ctccagcttg
    19081 gcgtagaggt agtcctcggc ctgctcccac ggcatgtcct gcgcgagctt gtacccgacc
    19141 ttcgccgcgc gcagcaccac cgggttcatc gacgccagct tcgccgccag ctcaccggtg
    19201 cgctcacgca accgctccga cggcaccgct tcgttcacca gccgcatttc cgcggcacga
    19261 cggccgtcga acggttcgcc ggtcatgatg aagtacaacg cgtcgcgctg gctgaccgtg
    19321 gcggccagcg cccggctgac cacgccgccc ggcggaattc cccagttcac ttcggacagt
    19381 ccgaaccggg cggtctccgc ggcgatggcc aggtcgcagg cgaccagcgg ggtgaacgcg
    19441 ccgccgaagc accagccgtt gaccatcgcg atggtcggct tcgaccaggt ggacagccgc
    19501 ttccactgcc attccgcgct cgcgcggcgc acccggatct gcaccgcggc gtcaccggac
    19561 tcgtccacct cacggaagta ctcacgcagg tccatgcccg cggagaagga gtcaccggcg
    19621 ccggtgagca ccagcacccg gcaccgcgga tcaccctcca gcgcgtcgag cgtgcgcacc
    19681 atctcgtcgt tgagcgcggg gttcatcgcg ttgcgctttt ccgggcggtt gagcgtgacc
    19741 cacgcgatcc cgtcctcgaa atcgacgagc acgttctcgc cccagggtgc tgctgacatt
    19801 gatcgggtcc tctcgggttt tcagaacggg tagcgcgcgg attcggcgcg cacggtgacc
    19861 cactgggtct cggtgaaggc gtcgacgttg gcgcgggcgc cgccgacgcg gcccaccccg
    19921 gacgcgccga cgccgccgaa gggcgcggcc ggatcgtcgt tcaccgtctg gtcgttgatg
    19981 tgcaccaggc cgctgggaat gcggtcggcc agcgccagcc cggcggccgg gtcggcggtc
    20041 agaatgccca ggctcaggcc gtattcggag tccgcagcga attcggcggc ctcgtcgagg
    20101 gtgtcgaacg ggcgcacgca ggcgaccggg ccgaacacct cttcggcgta ggcggggatc
    20161 gacggcccgc agtcggcgag cacggtcggc ccgtagaacg gcccgtccgc ggtgccgccc
    20221 tgcaccagcc gcgccccggc ggcgacgctg cgatcgacca ggtcacgcac gcgggccagc
    20281 tgaccgtcgt cgatgatcgg gccgagcacg acgtcttcgg tgaacgggtc accgacgggg
    20341 agttgctcgg ccttcttgcc gagcagctcg acgtagcgct cgta
//
