LOCUS       NZ_CP015163            21101 bp    DNA     circular CON 05-MAR-2024
DEFINITION  Amycolatopsis albispora strain WP1 chromosome, complete genome.
ACCESSION   NZ_CP015163
VERSION     NZ_CP015163.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis albispora
  ORGANISM  Amycolatopsis albispora
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Complete genome sequence and analysis of deep-sea sediment isolate,
            Amycolatopsis sp. WP1
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9121443)
  AUTHORS   Wang,H., Chen,S. and Wu,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2016) Zhejiang University of Technology, College
            of Pharmaceutical Science, Chaowang Road No.18, Hangzhou 310014,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera assembler v. unspecified
            Genome Coverage                   :: 138.17X
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/05/2024 04:57:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,537
            CDSs (total)                      :: 8,472
            Genes (coding)                    :: 8,394
            CDSs (with protein)               :: 8,394
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 78
            CDSs (without protein)            :: 78
            Pseudo Genes (ambiguous residues) :: 0 of 78
            Pseudo Genes (frameshifted)       :: 26 of 78
            Pseudo Genes (incomplete)         :: 54 of 78
            Pseudo Genes (internal stop)      :: 6 of 78
            Pseudo Genes (multiple problems)  :: 7 of 78
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:20:37
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 804447
            Orig. end                         :: 825548
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP015163.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21101
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="5"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21101
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21101
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11101](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11101)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(1693..2319)
                     /locus_tag="A4R43_RS03980"
                     /old_locus_tag="A4R43_03905"
     CDS             complement(1693..2319)
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020638399.1"
                     /locus_tag="A4R43_RS03980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03905"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_205215237.1"
                     /transl_table=11
                     /translation="MTGRLGKVVSDITITADGYVAGPNQSEARPFGDDGGDGWGDQLHG
                     WMFDNPAEHQAEIDQLGSAGAFIMGRNMFGPVRDEWDRPWNGWWGDNPPFHAPVFVLTH
                     HARNPQPMEGGTTYHFVTDGIESALTQARAAAGDNDVLIQGGAETINQYLTAGLLDELR
                     LHIVPLTLGSGSRLFDGVPPLKLEQVKSRATSSVIHVSYRVLPSS"
     gene            complement(2379..3056)
                     /locus_tag="A4R43_RS03985"
                     /old_locus_tag="A4R43_03910"
     CDS             complement(2379..3056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020647366.1"
                     /locus_tag="A4R43_RS03985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03910"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_113691039.1"
                     /transl_table=11
                     /translation="MDVTSRAAQVAAVAALGEPTRRRLYELVVRRSGPVSRDEAAAETR
                     LPRTTVAFHLDRLVGDGLLDVVYERRTGRSGPGAGRPAKLYRRSSREIAVSLPDRRYEL
                     AGRLLADALQEAEATGASPRAVLDRRARELGQELGRTAQPDGAFAVLDRLGFEPHRTST
                     AIVLGNCPFHGLAKHQTELVCGMNLRLLQGLLDGLATTGLVARLAPSPGHCCVRLEGES
                     AGR"
     misc_feature    3055..3068
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.22"
                     /tool="antismash"
     misc_feature    complement(3058..3067)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.67"
                     /tool="antismash"
     misc_feature    complement(3060..3074)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            3136..3723
                     /gene="folE"
                     /locus_tag="A4R43_RS03990"
                     /old_locus_tag="A4R43_03915"
     CDS             3136..3723
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GTP_cyclohydroI"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635902.1"
                     /locus_tag="A4R43_RS03990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03915"
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_113691040.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 1.3e-64,
                     bitscore: 215.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPLRVVNGRTGVDVEAAQRAVADLLVALGHDPASEHLADTPRR
                     VADAYGELLTPREFNLTTFPNDEGYDELVLARGIPVQSLCQHHLLPFHGVAHVGYLPGE
                     RILGLSKLARVVELYARDLQVQERLTKQVADWLQQHLAPKGVGVVIEAEHMCMSLRGVR
                     ATGSSTVTSALHGVLRDDARSRQEFFGLAGIR"
     gene            3818..4423
                     /locus_tag="A4R43_RS03995"
                     /old_locus_tag="A4R43_03920"
     CDS             3818..4423
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157219.1"
                     /locus_tag="A4R43_RS03995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03920"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_113691041.1"
                     /transl_table=11
                     /translation="MRNNNDQVHAWVRAERLGLADFLEGLTEDEWRVPSLCEGWTVRDV
                     AAHMTLSTRMSLRLTIKGVLRSRGSVHRMFDVLARDRAARFTPAELVAQLRETADSRHL
                     TLGASPFDPLVDVLIHGQDVARPLGRPRPMPLDAAEAALEFVWNAKFYGARKRLRGQRL
                     VATDRDWTGGEGAEEVRGTVSDLLLLATGRTVRPALTA"
     gene            complement(4425..5135)
                     /gene="aztA"
                     /locus_tag="A4R43_RS04000"
                     /old_locus_tag="A4R43_03925"
     CDS             complement(4425..5135)
                     /codon_start=1
                     /gene="aztA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635597.1"
                     /locus_tag="A4R43_RS04000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03925"
                     /product="zinc ABC transporter ATP-binding protein AztA"
                     /protein_id="WP_113691042.1"
                     /transl_table=11
                     /translation="MSENTAAITLREVHAGYGHREVLHGITAEVPDGRLTAVVGANGAG
                     KSSLLNVIAGVLPTSAGSVTRRGQDRPAYVTQHSEVSDALPVTVRATVAMGRWAHRGPW
                     RRLTKKDRALVEDCLERLDITSIADRRLGTLSGGQRQRTLVAQGLAQQSGLLLLDEPAA
                     GLDLRARTLIDEALNAARDDGVTVLRVTHDLAVADQAEHCLLLRDGQLVAEGPPASVLT
                     PEQVAEAWGVPTVR"
     misc_feature    complement(5101..5114)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.68"
                     /tool="antismash"
     misc_feature    5147..5162
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.36"
                     /tool="antismash"
     misc_feature    complement(5149..5162)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.89"
                     /tool="antismash"
     misc_feature    complement(5149..5163)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.06"
                     /tool="antismash"
     misc_feature    5150..5163
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.95"
                     /tool="antismash"
     misc_feature    complement(5150..5165)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.56"
                     /tool="antismash"
     misc_feature    5153..5168
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 23.97"
                     /tool="antismash"
     misc_feature    complement(5155..5168)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.71"
                     /tool="antismash"
     misc_feature    5155..5169
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.0"
                     /tool="antismash"
     misc_feature    5156..5169
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.85"
                     /tool="antismash"
     misc_feature    complement(5156..5171)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     gene            5184..>6002
                     /gene="aztB"
                     /locus_tag="A4R43_RS43780"
                     /pseudo=""
     CDS             5184..>6002
                     /codon_start=1
                     /gene="aztB"
                     /gene_functions="other (smcogs) SMCOG1245: ABC transporter
                     protein, integral membrane"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159878.1"
                     /locus_tag="A4R43_RS43780"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="zinc ABC transporter permease AztB"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDWLLIPFEVSFVQRALVAGVLVSVVCALVGTWVVLRGMAFIGDA
                     MAHGMLPGVAIASLAGVNPLFGAALSAGAMALGVTALGRSRRLSQDTAIGLLFVGMLAA
                     GVIIVSHSQSFAVDLTAFLFGDVLAVGPGDLALLAGALVVVAVVSLLGYRSFTALTFDA
                     RKARTLGLRPGLANAVLLALVTLTIVASFRVVGTLLVFGLLIAPAAAATFWARRITTIM
                     LVAALLGVLATVTGLVVSWHWGTAAGATIAATAVLLFFASALLSAARRRKR"
     misc_feature    7028..7043
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.83"
                     /tool="antismash"
     gene            7166..8065
                     /gene="aztC"
                     /locus_tag="A4R43_RS04010"
                     /old_locus_tag="A4R43_03935"
     CDS             7166..8065
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene="aztC"
                     /gene_functions="transport (smcogs) SMCOG1252: cation ABC
                     transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673918.1"
                     /locus_tag="A4R43_RS04010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03935"
                     /product="zinc ABC transporter substrate-binding protein
                     AztC"
                     /protein_id="WP_113691044.1"
                     /transl_table=11
                     /translation="MRRVLCALVAVLLVTAGCTAEGESRSSIVVTTNILGDITRNIAGD
                     QAPVTVLMKANADPHSFGISAQQAAETERAGLIVYNGLGLEEGMLSTVRAAQESGVPVL
                     PVGERVNPISHPGGEVPDPHFWTDPGRVRDAVNVIAEQIIAEVDGVDAAAVRANADRYR
                     GEIEALDTTMTERFATIPPERRKLVTNHHVFGYLAQRFGFEVIGAVIPGGTTLASPSAA
                     DLKSLADAVRAAGVPAIFADSSQPDRLARVLAEQAGLHVAVTPLFSESLSEPGQGAATY
                     LEMMRANTEAIATSLTRP"
     gene            8086..9264
                     /gene="aztD"
                     /locus_tag="A4R43_RS04015"
                     /old_locus_tag="A4R43_03940"
     CDS             8086..9264
                     /codon_start=1
                     /gene="aztD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159884.1"
                     /locus_tag="A4R43_RS04015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03940"
                     /product="zinc metallochaperone AztD"
                     /protein_id="WP_113697332.1"
                     /transl_table=11
                     /translation="MAKSLFTRRRTVVGTAVAALALTACGAEQPAPRDNNAAAPAQATI
                     AEPVTVTYDGGIYVLDGKTLQVAKDIPLPGFNRLNAAGDDRHVMVSTSTGFRVLDAARG
                     VLMDNEVKAPKPGHVVRHHGKTVLFADGTGEVTVFDPKTIGDGPLPAPQYKTPEPHHGV
                     AVELANGELVTTIGNEDARPGIMVLDKDRKEIARNEQCPGVHGEAAAKGEAVVIGCETG
                     ALIYRNGTITKVTSPDPYGRIGNQAGSDVSPITLGDYKVDEAAELERPTRVSLIDTEQA
                     TLRHVELGTSYTFRSLARGPQGEALVLGTDGQLHVIDPVAGSVVRKIPVTGSWQEPLEW
                     QQPRPAIFVRGGTAYVSDPNKKEIHAVDLASGSKTATGALPGVPNEVSGVLG"
     gene            complement(9245..9919)
                     /locus_tag="A4R43_RS04020"
                     /old_locus_tag="A4R43_03945"
     CDS             complement(9245..9919)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014325.4"
                     /locus_tag="A4R43_RS04020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03945"
                     /product="NAD(P)-binding protein"
                     /protein_id="WP_113691045.1"
                     /transl_table=11
                     /translation="MTGPTLIIGFGAIGASAARLLLSTGLPAERLVVIDQRRTAVTEAA
                     DLGARTVLGDAADRSALRRTGIAGARHVIVAVQPDATAVFITMVAREMCAPDAVVVTAV
                     TDRKHVAHLRGADQVVISSDTAGAALAAGALGQRLAPAQQPGSGWLVQSRPVQSSEIGL
                     FLRECGASAIGVLRGGVRHLGAAAASLRLAAGDRIMIMCRGGVVPGPPGDPGTPATSPV
                     PR"
     gene            complement(10001..11101)
                     /locus_tag="A4R43_RS04025"
                     /old_locus_tag="A4R43_03950"
     CDS             complement(10001..11101)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159832.1"
                     /locus_tag="A4R43_RS04025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03950"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_113691046.1"
                     /sec_met_domain="T1TS (E-value: 1.7e-54, bitscore: 184.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEAGALAAVLSGPSGLGTAAARVAPRPDPLPEPGYAEMSWGDGS
                     ASPLYCPVVRRVDEPLAEEVDRRLVTWAADCGFTGKGLEQIGRAGFGKLVTLAHPDSDD
                     PDHLLIAAQLNAVWWAADDYYADDSELGAAPTELPPRLALVMSAMDPVAPAGEFTEQLD
                     EALRGDPILVGLNSAIGHLARHGSAVQVQRVCYSTFAMFVAWDAYAAWRYTGAYPPAWE
                     YLAARQHDSFYTSMTLIDAVGGYELPAHLYYEPRVRRALMQAGTACVLVNDLYSVAKDA
                     ADEHPVCNMVLQIAADRDCSIEEATEATVELHNSMVRDFQEGHRKLRAVPSPELHRFLD
                     GVRDWMAGGFEWHATNPRYQDSAKKS"
     gene            complement(11111..11962)
                     /locus_tag="A4R43_RS04030"
                     /old_locus_tag="A4R43_03955"
     CDS             complement(11111..11962)
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (84-246). E-value: 1.1e-16. Score:
                     51.9. Matches aSDomain: nrpspksdomains_A4R43_RS04030_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004560971.1"
                     /locus_tag="A4R43_RS04030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03955"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_113691047.1"
                     /transl_table=11
                     /translation="MTSLDRPVLRTAYQRSVADYWDKEKDPVNLRLGEIDGLFHHHYGI
                     GDYDPAVLEAPEETRDDAIIAEMHRLETAQADVLLDHLGPISPGDRLLDAGCGRGGTSV
                     MAHQRFGCRVDGVSISRQQVEFANAQAAKLGVDGHVAYHERNMLDTGFETGAFAGIWNN
                     ESTMYVDLGDLFAEHARQLAPGGRYVTITGCYNDVTGGRSRAVSQIDQHYICNIHARGD
                     YFKALADNGFVPINVVDLTAATIPYWELRARSSVATGIEEPFLTAYREGSFHYLLIAAD
                     RV"
     aSDomain        complement(11225..11710)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS04030_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.10E-16"
                     /label="A4R43_RS04030_oMT.1"
                     /locus_tag="A4R43_RS04030"
                     /protein_end="246"
                     /protein_start="84"
                     /score="51.9"
                     /tool="antismash"
                     /translation="PISPGDRLLDAGCGRGGTSVMAHQRFGCRVDGVSISRQQVEFANA
                     QAAKLGVDGHVAYHERNMLDTGFETGAFAGIWNNESTMYVDLGDLFAEHARQLAPGGRY
                     VTITGCYNDVTGGRSRAVSQIDQHYICNIHARGDYFKALADNGFVPINVVDLTAATIP"
     misc_feature    12037..12052
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    complement(12187..12201)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            12294..12860
                     /locus_tag="A4R43_RS04035"
                     /old_locus_tag="A4R43_03960"
     CDS             12294..12860
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF028235.4"
                     /locus_tag="A4R43_RS04035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03960"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_113691048.1"
                     /transl_table=11
                     /translation="MLKGERTRAKLVAAAREVVEAKGYHGTGLNEVLAVAGAPRGSLYH
                     HFPGGKDELIGEALSAAGQEVDALLDELAASAAGARELVLALLTALADRMAAADYAKGC
                     PVATVALEVAASEGELRSLCGGIYDGWQHKLADALRAEGRAEADELAATVLALVEGALV
                     LARARRSRGPVEQVSRRVGRLLELE"
     gene            12866..14461
                     /locus_tag="A4R43_RS04040"
     CDS             12866..14461
                     /NRPS_PKS="Domain: NAD_binding_4 (12-237). E-value:
                     9.8e-32. Score: 101.9. Matches aSDomain:
                     nrpspksdomains_A4R43_RS04040_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013530.4"
                     /locus_tag="A4R43_RS04040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_113691049.1"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.4e-29, bitscore:
                     101.9, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSAGRSDSVVFGATGFLGRWIVLHLLGRGRTVAAVARRPGDLRD
                     WLVARGAVVDRLELVTGDLAAGDDLGLSAEDNARLADVRDVFNAAGVYRFGLRREEAVP
                     VNVDGAVRVVRWAKTRPKLRRLVHVSGYRVGREPRPRYPIPDAELAALYRSKGAYEGSK
                     FEADAAVRVLSERLGVPLTVVNPSTVIGHSVTGEAGQYVGLAELVRDLWTGKLPALPGS
                     ARTFVPVVTVDHFAEFTAAVPEHDAAGSHWVLDGHTPELPALVRLLAAHLGVRAPKLKV
                     PVGLLRRLPAAVARADPETLSFLSEDRYDTASAERIAATAGLSHPPVETALRRWADRLV
                     ADGFGAAPAVLPGGFHEVAGSRAYVAGARVEPDYVLLQGLEPSAEPWREIVGELGSVLT
                     ADLPGLGRSAPSALAPHDWLAELLAPVRTRPVIVAHQAAAEPVLRFAAAHPDRLATVVL
                     VPPGFFTAGPVAVPSRPGAARRRVRWQRAAADPARVRARYGTVPVVFAASGAEIVAAGE
                     GRLGAVGHRDGLGS"
     aSDomain        12902..13576
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R43_RS04040_NAD_binding_4.1"
                     /evalue="9.80E-32"
                     /label="A4R43_RS04040_NAD_binding_4.1"
                     /locus_tag="A4R43_RS04040"
                     /protein_end="237"
                     /protein_start="12"
                     /score="101.9"
                     /tool="antismash"
                     /translation="GATGFLGRWIVLHLLGRGRTVAAVARRPGDLRDWLVARGAVVDRL
                     ELVTGDLAAGDDLGLSAEDNARLADVRDVFNAAGVYRFGLRREEAVPVNVDGAVRVVRW
                     AKTRPKLRRLVHVSGYRVGREPRPRYPIPDAELAALYRSKGAYEGSKFEADAAVRVLSE
                     RLGVPLTVVNPSTVIGHSVTGEAGQYVGLAELVRDLWTGKLPALPGSARTFVPVVTVDH
                     FAE"
     gene            complement(14462..15187)
                     /locus_tag="A4R43_RS04045"
                     /old_locus_tag="A4R43_03970"
     CDS             complement(14462..15187)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020634027.1"
                     /locus_tag="A4R43_RS04045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03970"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_113691050.1"
                     /transl_table=11
                     /translation="MRLRSLAVLIGSALMALLGLAAPSTAAPATEPGTVQPFIIGGQYA
                     TSGPWAARLFVNGRQTCTATIIAPQYILTAKHCVASSGTYTFRIGSLDQQSGGTMATGS
                     TITRYPGSADLAIVRLTTTVNATYSPLGTTSDVSTGQTVQVYGWGATSRCGSEINCQSR
                     YLKYANVRVNSVNCSDYYGGISVCANRIDGITAGGDSGGPMFASGRQVGVASTSDRSNN
                     TAYTNITRYRSWIQQVAGV"
     misc_feature    complement(15291..15306)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.12"
                     /tool="antismash"
     misc_feature    complement(15790..15808)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 21.16"
                     /tool="antismash"
     gene            15814..17307
                     /locus_tag="A4R43_RS43155"
                     /old_locus_tag="A4R43_03975"
     CDS             15814..17307
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="A4R43_RS43155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03975"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_205215238.1"
                     /sec_met_domain="Pkinase (E-value: 1.6e-39, bitscore:
                     134.7, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGRFKPLTPEDPREVGGYRLRARLGVGGMGRVYLAFSPGGRALA
                     IKVVRTEHAEDEEFRRRFRQEIASAQRVQGIYTAQVIDADAEADVPWLATAYVPGPSLR
                     EAVADHGPLPPETVSRLLAGVAEGLAAVHACDIVHRDLTPANVLLAEDGPRVIDFGIAH
                     AAAATSLTRTGMSIGTPAFMSPEQVRGQAVTAATDVFALGHLAVFAATGRPAFGEGNRD
                     ALFYRVLSEDPDLTGCPEAIRPIVARCLAKEPGDRPSLEEVMAEAGEHADLKLSGDWLP
                     DSVTEVFKRFDTALYTVHEGQKEPKPRKPPKPPEQKEKRSVPVGGLLGAATLVAILVIG
                     SIGPDKVLNAADEFFASAKSTSTTTKRATTTKKTTTTTRTPVRRATTERTTTTTRTTDR
                     KSKQEACSAAERAFDKLENTTISSDRQENAAAYRRLSRDLAEAGDGASDSTVRSKLSRL
                     SSGYSTAADYLYDDRPGAFSTLAADLDSDADELRDLCRG"
     gene            complement(17312..17842)
                     /locus_tag="A4R43_RS04055"
                     /old_locus_tag="A4R43_03980"
     CDS             complement(17312..17842)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026899.4"
                     /locus_tag="A4R43_RS04055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R43_03980"
                     /product="Imm15 family immunity protein"
                     /protein_id="WP_113691051.1"
                     /transl_table=11
                     /translation="MTAEIDPRFRAEFDRLLADGDLLDFDGLMSYDGYFDELPLYATYR
                     QISFLDELPPLERNQVLVRAAAAHLGRVLAHAEEFYAGREFDFFCAVTVTGWDHLPEGD
                     PLTPHFWLANPSRGVFEHLRLRPPGSEGSNMVAHLLGHDPAYLLNDDLVDGRLERVWVQ
                     QADHPVPPGTVEA"
     misc_feature    18145..18159
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.13"
                     /tool="antismash"
     misc_feature    complement(19302..19317)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.48"
                     /tool="antismash"
     misc_feature    complement(19911..19925)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    20329..20343
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     misc_feature    20557..20571
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.75"
                     /tool="antismash"
     misc_feature    20875..20889
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     misc_feature    complement(20983..20998)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.05"
                     /tool="antismash"
ORIGIN
        1 gtgttcggtg tggtgaacac gctggccctg tccgtgttgg agcgcacccg ggaaatcggc
       61 atgatgcggg cgatcggcgc ttcccggtcg ctggtccggc gcatggtcca ggccgagagc
      121 atcgcgatct cgctgttcgg cgcgggtctc ggagtggtca ccggcctcgg ggcgggcacg
      181 gtgatgcagc acgccatgct cggccagtca ctcggggacg cctcagtgcc gctggatgtg
      241 atcgcgatct gcctcctggg catggtgctc gccgccgtac tggccgccct gtggcccgcc
      301 cgacgtgcag caagaacgga ggtgctaccc gcaatcgccc cctaacccca aatcccgacg
      361 tcagcccaga aacccggcag gcccaagcac ccaagggcgc tcgaccggcc gcgactcccg
      421 gccgtacgca gccgaccgat cgcttcgtgc ccccggcggg cgtggtcacg ttgaggtaca
      481 ggcagtcctc gttcgtgctg ccctgcggtg cttccgggcc ctcttgacaa agaatcccgg
      541 cgtgacacag cgaaagaccg gacgagcgac cgagggcgat cggtcggcca gggcgactgc
      601 caggcgcgag cggccgaccg atcactctca aacaagagaa tcccggcttg gcacagcaga
      661 aggccagggc gagcgaccgg gggtgagcgg cggtcaggcg aattcgaggt gtagagggcc
      721 gggcgaccgc cgcctagcaa gaaatcccgg cgtggcgcgg tggaaggccg ggacgagcga
      781 ccgggggtga gcggcggtca ggcgaatccg gggcgtagat cgccgggcga ccgccctctg
      841 acaagagaat cccggcttgg tccagcggaa ggccagtgga gagagaccga ggtcgatcga
      901 tcggcaaggg cggccctcgg gcgtaagcgg ccgaccgatc agtctctaac acgcgaatcc
      961 cggtgtggct tagcgaaacc cggaggggtg agagaccgag tgcgagcgtg cggtcaggcc
     1021 gaatcccgga cgttagtcgc cgggcgatcg tccgctaaca aaagaatctc ggcgtggcgt
     1081 agcggaaacc gagggcgatc ggtcggtcag ggtggcccgg gcgtaaggga ctgggcgatc
     1141 gccacgcatc ccgggcgccc tgttggccgc agttgccgcc agcagggcgg ccgagccgat
     1201 tggcacgccc tcggtgacca gcgcccaaca cccgccctgg tacggaaccg gggccaccca
     1261 ccagcacgac gacggcctcg cgagcggacc cagacgatcg accacaaagg acacttccgg
     1321 gtccgcttct ccgtctgctc gacgtgtccg gactggcgcc ggacacgtcg agtacaaccg
     1381 acaagcatct ttgatcgccg acagaaggcg ggactgcagt gcccgctgac cacggtgttg
     1441 ccccgatggg agtgccaggc gacgccgatt cggctacggc cagcttcgcg aacggccggg
     1501 ctcgagcgtg tccactaagg acacgtttcc gggctccgct ctccgggaac cgggcggacg
     1561 tgcgccgagc atcaggtggt caccgatagg gaagggatct gcggcggccg ttgaccgggg
     1621 gcctgctcgc cgcggtcgat gtgggcgggg tggcgaccgt cccgggctga aggccaccgt
     1681 ggcggtgggt gtctaagagg aaggcagcac tcggtaggac acgtggatga ctgaactcgt
     1741 ggcccgcgac tttacttgtt ccagtttcag cggcgggacg ccgtcgaaga ggcgggagcc
     1801 ggagccgagg gtcagtggca cgatgtgcag ccgcaactcg tcgaggaggc cggcggtgag
     1861 gtattggttg atcgtttccg cgccgccctg gatcaggacg tcgttgtcgc cggcggcggc
     1921 gcgggcttgg gtcagggcgg attcgatgcc gtcggtgacg aagtggtagg tggtgccgcc
     1981 ttccatgggc tgcgggttgc gcgcgtggtg cgtgagcaca aaaaccgggg cgtggaacgg
     2041 cgggttgtcc ccccaccagc cgttccacgg gcggtcccat tcgtcacgga ccgggccgaa
     2101 catgttgcgg cccatgatga aggcgccggc ggagcccagc tgatcgatct cggcctggtg
     2161 ctcggcgggg ttgtcgaaca tccagccgtg cagttggtcg ccccagccgt caccgccgtc
     2221 gtcgccgaag gggcgtgcct cgctctggtt ggggccggcc acgtacccgt cggccgtgat
     2281 cgtgatgtcg ctgaccacct tgcccagtcg tccggtcatc gcgctgtcct cctgtagtcg
     2341 gggctttcgt caggacagac cacgcggaag cgcgaaactc atcggccggc cgattctcct
     2401 tcgagacgta cacagcagtg cccgggggag ggggcgaggc gggcgaccag cccggtggtg
     2461 gcgaggccgt cgagcaggcc ctggagcagg cggaggttca tgccgcagac aagctcagtc
     2521 tggtgcttgg ccaggccgtg aaacgggcag ttgcccagca cgatcgcggt gctggtgcgg
     2581 tgtggctcga agccgaggcg gtccagcacg gcaaaggcgc cgtcgggctg ggcggtccgg
     2641 ccgagttcct ggccgagttc gcgggcacgc cggtccagca cggcacgcgg ggacgcgccc
     2701 gtggcctcgg cttcctggag ggcgtcggcg agcaggcggc ccgccagttc gtagcgccgg
     2761 tccggcagcg agaccgcgat ctcccgcgac gagcggcggt acagcttggc cgggcgaccg
     2821 gcgccggggc cgctgcggcc ggtgcggcgc tcgtacacca cgtcgagcag gccgtcgccg
     2881 acgaggcggt cgaggtggaa cgccacggtg gtgcgcggca accgcgtctc cgccgcggcc
     2941 tcgtcccggc tgaccgggcc ggaccggcgc acgacgagct cgtacaaccg gcggcgggtc
     3001 ggctcgccga gtgcggcgac cgcggcgacc tgtgcggctc gcgatgtgac gtccatttct
     3061 aaaaacgatc tccgttgact gaattggacg gggggttcta aggttagcgc gacttggtgt
     3121 tagaaggagg ggcgtatggc cgcgccgttg cgggtggtga acgggcgtac cggcgtcgac
     3181 gtcgaggcgg cgcagcgggc ggtggccgat ctgctggtcg cgctggggca cgacccggcg
     3241 tcggagcacc tggccgacac gccgaggcgg gtcgccgacg cgtacggcga gctgctcacc
     3301 ccgcgcgagt tcaacctgac caccttcccc aacgacgagg gctacgacga gctggtgctc
     3361 gcccgcggca tcccggtgca gtcgctgtgc cagcaccacc tgctgccgtt ccacggcgtc
     3421 gcgcacgtcg gctacctgcc cggcgagcgc atcctcgggc tgtcgaagct ggcgcgcgtg
     3481 gtcgagctgt acgcccgcga cctgcaggta caggagcggc tgaccaagca ggtggccgac
     3541 tggctgcagc agcacctcgc gcccaagggc gtcggcgtgg tgatcgaggc cgagcacatg
     3601 tgcatgtcgc tgcgcggggt gcgggccacc gggtccagca cggtgacctc cgccctgcac
     3661 ggggtgctgc gggacgacgc gcgctcgcgg caggagttct tcgggctcgc cggcatccgc
     3721 tgagcgagcc ctcgaaaaat ttcctgcgcg ggtgtccttc cgccggtggc tcgttcgtgg
     3781 tgatggcgaa cgagcagccg acagcaggga gcgcgtcatg cggaacaaca acgaccaggt
     3841 ccacgcctgg gtccgggccg agcggctcgg cctcgccgac ttcctcgagg gcctgaccga
     3901 ggacgaatgg cgcgtgcctt ccctctgcga gggctggacc gtgcgcgacg tcgccgccca
     3961 catgaccttg tccacgcgga tgtcgctgcg gctgaccatc aagggcgtgc tgcggtcgcg
     4021 gggcagcgtg caccgcatgt tcgacgtgct ggccagggac cgcgcggccc ggttcacccc
     4081 cgccgaactg gtggcgcagc tgcgtgagac ggcggactcc cggcacctca cgctcggcgc
     4141 cagcccgttc gacccgctgg tcgacgtgct gatccacggg caggacgtgg cccggccgct
     4201 gggcaggccg cgtccgatgc cgctcgacgc ggcggaggcg gcgctcgagt tcgtctggaa
     4261 cgccaagttc tacggcgcgc ggaagcggct gcgcggccag cgactggtcg ccaccgaccg
     4321 cgactggacc ggcggcgagg gagccgagga ggtccggggc acggtctcag acctgctgct
     4381 gcttgccacc ggccggaccg tgcgccccgc gctgaccgcc tgagtcaccg caccgtcggc
     4441 acaccccacg cctcggccac ctgttccggg gtcagcaccg aagcgggcgg gccttcggcg
     4501 accagctgac cgtcgcgcag tagcaggcag tgctccgcct gatcggcgac ggcgaggtca
     4561 tgcgtgacac gcaggaccgt cacgccgtcg tcgcgggcgg cattcagcgc ttcgtcgatc
     4621 agcgtcctgg ctcgcaggtc cagtccggcc gccggttcgt cgagcaacag cagtccggac
     4681 tgctgcgcca ggccttgcgc caccagcgtc cgctgccgct gcccgccgga cagggtgccg
     4741 agcctgcggt cggcgatcga ggtgatgtcc aggcgctcca ggcagtcttc gaccagtgct
     4801 ctgtcctttt tggtcagacg acgccacgga ccgcgatggg cccagcggcc catggcgacg
     4861 gtggcacgca ccgtgaccgg cagcgcgtcg gacacctcgc tgtgctgggt cacgtacgcc
     4921 gggcggtcct ggccgcggcg cgtcaccgag cccgcgctgg tgggcagcac gccggcgatc
     4981 acgttgagca gggacgactt cccggctccg ttcgcgccga ccaccgcggt gagccgcccg
     5041 tccggcacct ccgcggtgat cccgtgcagc acttcccggt ggccgtaccc cgcgtgcact
     5101 tcacgcaggg tgatcgccgc cgtgttctcg ctcatctgac accgcccatg ataatgacaa
     5161 tcattaccac tatagtgtcc ggcgtggact ggttgctgat ccccttcgag gtgtcctttg
     5221 tgcagcgtgc gctcgtcgcc ggagtgctcg tgtcggtggt gtgcgcgctc gtgggcacct
     5281 gggtggtgtt gcgcggcatg gccttcatcg gcgacgcgat ggcgcacggc atgctccccg
     5341 gggtggcgat cgcctcgctg gccggggtga acccgttgtt cggcgcggcg ctgagcgccg
     5401 gggcgatggc gctgggcgtg accgcgctcg ggcggtcgcg gcggttgtcg caggacaccg
     5461 ccatcggcct gctctttgtc ggcatgctcg cggccggtgt gatcatcgtc tcgcattcgc
     5521 agtcgttcgc ggtcgatctc accgcgttcc tgttcggtga cgtgctcgcg gtcggccccg
     5581 gcgatctggc cctcctggcg ggcgcgctgg tggtcgtggc ggtggtgtcg ctgctcggct
     5641 atcgctcgtt caccgcgctg accttcgacg ccaggaaggc gcgcacgctc ggcctgcggc
     5701 cgggactggc gaacgccgtg ctgctggcgc tggtgacgct gaccatcgtc gcgtcgttcc
     5761 gcgtggtcgg cacgctgctg gtgttcggcc tgctcatcgc gcccgcggcg gcggccacct
     5821 tctgggcgcg gcggatcacc acgatcatgc tggtggccgc gctgctcggg gtgctggcca
     5881 cggtcaccgg gctggtggtc tcctggcact gggggaccgc ggccggggcg accatcgcgg
     5941 cgacggccgt gctgctgttc ttcgcctccg cgctgctgtc cgccgcgcgc cgccggaagc
     6001 ggtggggcgc gggcgctctc gcggccgtgt cgttgttcgc gacggcctgc gcgcccgaac
     6061 cggagccggc cgcgcccgcc gcggaagtgc cgcacggcta cgtcgaaggc gccgaggaaa
     6121 ccgccgaggc gcagtcgcgg ctggtggtgg ccgacgccgg aacgggggcc gtgcgcgtgg
     6181 tggacctgat caccgagcag gtccacccgg cgggccaggt cgacggggtg cgtgccatca
     6241 ccggggacgg gcggttcgcc tacctcaccg gacgggacga ctcggtccgc gtggtggaca
     6301 gcggatcgtg gatggtcgac cacggcgacc acgtgcacta ctaccgcgcg gcggtccgcg
     6361 aagtcggtgt ggcgccgggg aagcaggcgc tcggcgcgta cagcgacccg gcggtgaccg
     6421 cggtgtccta tccggacggt acggcgatcc tgctcgaccg tgcgcggctc gacaaggggg
     6481 aaatcacgga actggggaag atcgcccacg gaccgcatcc gggcatcgcc gtgccgtacg
     6541 gggagaaagt cttggcttcc gacggctcgc gtggtgtacg cgtccacgat cgccagggga
     6601 acgcggtgtc ggacatcgaa cccgcgtgcc cggaactcca gggccaggcg gtcacccggc
     6661 gcggcgtggt cttcggctgc gcggacggtg ccctgctggt caccgagaag gacggcgtgt
     6721 tcgcgggcga gaaaatcccg tacccgcagg aggttccccc gcaggaacgc gcgacgaagt
     6781 tcacccaccg cccgggcagc accacgctcg cggcgcccgc cggggagaac gccgtgtggt
     6841 cactggacgt cagccgccgg gcgtggagcc gggtggcgac cgggccggtc gccgcggtga
     6901 acgcggtggg ggagggcgcg ccgctgctgg tgctgacccg cgacggcgtg ctgcgtgcct
     6961 acgacgaaac caccggtcag gaacgcgcgc aggccccgtt gatgccggac gcgaccggcg
     7021 ccgcgatcca ggtcgacacc acccgcgcct acgtcaacaa ccccgcttcg ggagaggtgt
     7081 acgaaatcga ctacaacgac aacctgcgcc gcgccaggac gttcaccgtc gaaggcaagg
     7141 ccagctactt cgtggagacc gggcgatgag gcgggtgctc tgcgcgctgg tcgccgtgct
     7201 cctggtgacc gcgggatgca ccgcggaggg tgagagccgc tcgtcgatcg tggtgaccac
     7261 gaacattctc ggggacatca cccgcaacat cgccggtgac caggccccgg tgaccgtgct
     7321 gatgaaggcg aacgccgacc cgcattcgtt cggcatctcc gcccagcagg ccgccgaaac
     7381 cgaacgcgcc ggcctgatcg tctacaacgg actcgggctg gaagagggca tgctgagcac
     7441 cgtgcgggcc gcgcaggaga gcggggtgcc ggtgctgccg gtgggggagc gggtgaaccc
     7501 gatcagccat cccggcggtg aggtacccga tccgcacttc tggaccgacc ccggccgcgt
     7561 gcgcgacgcg gtgaacgtga tcgcggagca gatcatcgcc gaagtggacg gggtggacgc
     7621 ggcggccgtg cgggccaacg ccgaccggta ccgcggtgag atcgaagcgc tcgacaccac
     7681 gatgaccgag cggttcgcga cgatcccgcc cgagcgccgg aaactggtca ccaaccacca
     7741 cgttttcggt tacctcgcgc agcgtttcgg cttcgaggtg atcggcgcgg tgatccccgg
     7801 tggcaccacg ctcgcctcac ccagcgccgc cgatctgaag tcgctggccg acgcggtccg
     7861 cgcggcgggc gttccggcca tcttcgcgga ttcctcgcaa ccggaccgcc tcgcgcgggt
     7921 gctggccgag caggccgggc tgcacgtggc ggtgacgccg ctgttctcgg aatcgctgag
     7981 cgaaccgggc cagggcgcgg ccacctacct ggaaatgatg cgcgccaaca ccgaggcgat
     8041 cgcaaccagc ttgacccgtc cgtgaaaagg aaaggtgtag tggaaatggc aaaatcgctg
     8101 ttcacccgtc gacgaacggt ggtgggcacc gcggtggccg cgctggcgct gacggcctgc
     8161 ggtgccgagc agcccgctcc gcgggacaac aacgcggcgg caccggcgca ggcgaccatc
     8221 gccgaacccg tcaccgtcac ctacgacggc gggatctacg tgctggacgg gaaaaccctc
     8281 caggtggcca aggacatccc gttgccgggc ttcaaccgcc tcaacgcggc gggcgacgac
     8341 cggcacgtca tggtgtccac ctccaccggg ttccgcgtgc tcgacgccgc ccgcggggtg
     8401 ctgatggaca acgaggtcaa ggcgcccaag ccggggcacg tggtccgcca ccacgggaaa
     8461 accgtgttgt tcgcggacgg caccggtgag gtgaccgtgt tcgacccgaa gacgatcggc
     8521 gacggcccgc tgcccgcgcc gcagtacaag acgccggaac cgcaccacgg tgtcgccgtc
     8581 gaactcgcga acggcgagct ggtcaccacc atcggcaacg aggacgcgcg gccgggcatc
     8641 atggtgctgg acaaggaccg caaggagatc gcgcgcaacg agcagtgccc cggcgtgcac
     8701 ggcgaagcgg ccgcgaaggg cgaggcggtg gtgatcggct gcgaaaccgg tgcgctgatc
     8761 taccgcaacg gcaccatcac caaggtcacc agccccgacc cgtacggccg gatcggcaac
     8821 caggcgggct ccgacgtctc gccgatcacg ctcggcgact acaaagtgga cgaagccgcc
     8881 gaactggagc gcccgacccg ggtttcgctg atcgacaccg agcaggccac gctccggcac
     8941 gtcgaactcg gcaccagcta caccttccgc tcgctggccc gcggcccgca gggggaggcg
     9001 ctggtgctcg gcaccgacgg gcagctccac gtgatcgacc cggtggccgg ttcggtggtg
     9061 cgcaagatcc cggtgaccgg ttcgtggcag gaaccgctgg agtggcagca gccgcgcccg
     9121 gcgatcttcg tccgcggtgg cacggcctac gtcagcgacc cgaacaagaa ggagatccac
     9181 gcggtggacc tcgcttcggg cagcaaaacc gcgaccggcg cgctgcccgg cgtgccgaac
     9241 gaggtcagcg gggtactggg ctagtggcgg gggtgccggg atcaccaggc ggtcccggca
     9301 ccaccccgcc ccggcacatg atcatgatcc ggtcgccggc ggccagccgg agcgacgcgg
     9361 ccgcggcacc gaggtgccgc accccgccgc gcagcacacc gatcgcgctc gccccgcact
     9421 cccgcaggaa caagccgatt tcggaggact ggaccggccg cgactgcacc agccagccgg
     9481 aacccggctg ctgcgcgggc gcgagccgct ggcccagcgc gcccgcggcc agtgccgcgc
     9541 ccgcggtgtc cgacgagatg accacctggt cggcgccgcg gaggtgggcc acgtgcttgc
     9601 ggtcggtgac cgcggtgacc accaccgcgt ccggcgcgca catctcccgc gccaccatgg
     9661 tgatgaacac cgcggtggcg tccggctgca cggccacgat gacgtgccgc gcgcccgcga
     9721 tccccgtccg ccgcagggcg gagcggtcgg cggcgtcacc gagcaccgtg cgcgcgccca
     9781 ggtccgccgc ctcggtgacg gccgtccgcc gctggtcgat gaccacgagc cgctcggcgg
     9841 gaaggccggt ggacagcagc aatctggcgg cggaggcgcc gatcgcgcca aaaccgatga
     9901 tcagggtcgg gccggtcaac gggtcccccg gtgtggtcgg cgcatggagc gcgagtagac
     9961 cgggggaccg gccgcggcga gaaggtcctt ggcggaatat ttacgacttc tttgcgctgt
    10021 cctggtagcg cggattggtc gcgtgccact cgaaaccgcc cgccatccag tcgcggacgc
    10081 cgtcgagaaa gcggtgcagc tccggtgacg gcaccgcccg cagtttccgg tggccctcct
    10141 ggaagtcccg caccatcgag ttgtgcagtt cgacggtggc ctcggtggct tcctcgatgg
    10201 agcagtcccg gtcggccgcg atctgcagca ccatgttgca caccgggtgc tcgtcggcgg
    10261 cgtccttcgc caccgagtac aggtcgttga ccagcacgca cgccgttccg gcctgcatga
    10321 gcgcccggcg gacccgcggt tcgtagtaca ggtgcgccgg cagttcgtac ccgccgaccg
    10381 cgtcgatcag cgtcatcgac gtgtagaagc tgtcgtgctg ccgcgcggcc aggtactccc
    10441 acgcgggcgg gtacgcgccg gtgtagcgcc aggccgcgta ggcgtcccac gccacgaaca
    10501 tcgcgaacgt ggaatagcag acccgctgca cctgcacggc gctgccgtgc cgcgccaggt
    10561 gcccgatggc cgagttcagc ccgaccagga tggggtcgcc gcgcagggct tcgtcgagct
    10621 gctcggtgaa ctccccggcc ggtgcgaccg ggtccatcgc cgacatcacc agcgccagcc
    10681 gcggcggcag ttcggtcggc gcggcaccga gttcgctgtc gtcggcgtag tagtcgtcgg
    10741 ccgcccacca gaccgcgttc agctgcgccg cgatcagcag gtggtccggg tcgtcggaat
    10801 ccgggtgggc cagcgtgacc agcttgccga acccggcgcg gccgatctgc tccaggccct
    10861 tgccggtgaa cccgcagtcc gccgcccagg tgaccaggcg gcggtccacc tcctcggcca
    10921 gcggctcgtc gacccgccgg accaccgggc agtacagcgg ggacgcgctg ccgtcgcccc
    10981 agctcatctc ggcgtacccc ggttcgggca gcgggtccgg ccgcggcgcg accctggcgg
    11041 ccgcggtgcc caggcccgac ggcccggaca gcacggcggc cagcgctccg gcctcctgca
    11101 tgcgcacccc tcagacccgg tcggcggcga tgagcaggta gtggaagctg ccttcgcggt
    11161 aggcggtgag gaacggttcc tcgatgccgg tggccaccga cgagcgcgcc cgcagctccc
    11221 agtacggaat ggtggcggcg gtcaggtcga ccacgttgat cggcacaaaa ccgttgtccg
    11281 ccagcgcctt gaagtagtca ccgcgggcgt ggatgttgca gatgtagtgc tggtcgatct
    11341 ggctgaccgc gcgcgagcgg ccgccggtca cgtcgttgta gcagccggtg atcgtcacgt
    11401 agcggccgcc gggggcgagc tgccgggcgt gctcggcgaa caggtcgccc aggtccacgt
    11461 acatggtcga ctcgttgttc cagatgccgg cgaaggcacc ggtttcgaag ccggtgtcca
    11521 gcatgttgcg ctcgtggtag gccacgtggc cgtccacccc gagcttggcc gcctgcgcgt
    11581 tcgcgaactc cacctgctgc cgggaaatcg acacgccgtc cacccggcag ccgaaccgct
    11641 ggtgcgccat cacgctggta ccgccgcggc cgcacccggc gtcgagcagg cggtcgccgg
    11701 gggaaatggg gccgaggtgg tcgagcagca cgtccgcctg cgcggtttcc agccggtgca
    11761 tttccgcgat gatcgcgtcg tcgcgggttt cttccggggc ttcgagaacg gccgggtcgt
    11821 aatcgccgat gccgtagtgg tggtggaaaa ggccgtcgat ttcacccagc cgaaggttga
    11881 ccggatcctt ctccttgtcc cagtagtcgg cgactgaacg ctggtaggcg gtgcgcagca
    11941 cgggacgatc aagagaagtc attccagcgg ctccttgaca tctgtcggca tcggtgatct
    12001 cgcgtatata tctctagtat gctctagctt tgttcgacgc cgttgccgaa cgcggccaac
    12061 gctagacttc gcttctcgcc cgggacaaga cggccgatcg cggttcactc tggggtggcg
    12121 ggggtatggg caagacctgc ctggctggcc taattcgcgc atccggcggt cggtccggaa
    12181 atggtgtgga accgactttc ggcgccattt tcctccctaa tggctgacgc cccattcact
    12241 gtcggtgccc ggggcccttg cggagattat gtagatcggt ctactctgac ggcgtgctga
    12301 agggtgagcg gacgcgggcc aagctggtcg ccgcggccag ggaggtggtg gaggcgaagg
    12361 ggtaccacgg caccgggctg aacgaggtgc tcgcggtggc cggtgcgccg cggggatcgc
    12421 tgtaccacca cttccccggc gggaaggacg agctgatcgg ggaggcgttg agcgctgccg
    12481 gtcaggaggt cgatgcgctg ctggacgagc tggccgcctc ggcggcgggt gcccgtgaac
    12541 tcgtgctcgc cctgctgacc gcgctggcgg accggatggc ggcggcggac tacgcgaagg
    12601 gctgcccggt ggcgaccgta gcgctggagg tcgcggcgtc cgagggggaa ctgcggtcgc
    12661 tgtgcggcgg catctacgac ggctggcagc acaagctggc cgacgccctg cgagccgagg
    12721 ggcgggcgga ggcggacgag ctggccgcga ccgtgcttgc gcttgtcgaa ggcgcgctgg
    12781 tgctggcgcg ggcgcggcgc agccgggggc ccgtcgagca ggtcagccgt cgcgtcggcc
    12841 gcctactgga gctggagtga ccacaatgga cagtgcaggc agaagcgaca gcgtggtgtt
    12901 cggcgccact gggtttctcg gccggtggat cgtgctgcac ttgctgggcc ggggccgcac
    12961 ggtcgcggcc gtggcgcgcc gccccggtga cctgcgtgac tggctggtgg cgcggggcgc
    13021 ggtggtcgat cggctggagc tggtgaccgg tgatctcgcg gccggtgacg acctcgggct
    13081 gagcgccgag gacaacgcgc ggctggcgga tgtgcgcgat gtgttcaacg cggccggggt
    13141 ctaccgcttc ggcctgcggc gtgaggaggc cgtgccggtc aacgtcgatg gtgcggtgcg
    13201 ggtggtgcgg tgggcgaaaa cccggccgaa gctgcgccgg ctggtccacg tttccgggta
    13261 ccgcgtcggg cgcgaaccgc ggccgcggta cccgattccg gacgcggaac tggcggcgct
    13321 gtaccggagc aagggcgcct acgagggttc gaagttcgag gcggacgccg ccgtgcgcgt
    13381 gctctcggag cggctcggcg tgccgctgac cgtggtgaat cccagtactg tcatcggtca
    13441 ttcggtgacc ggcgaggcgg gccagtacgt cggcctggcc gagctggttc gtgatctgtg
    13501 gaccgggaag ctgcccgcgt tgccgggcag cgcacgcacc ttcgtgcccg tggtgaccgt
    13561 ggaccacttc gcggagttca ccgccgcggt tcccgaacac gatgccgccg gcagccattg
    13621 ggtgctcgac gggcacacgc cggaactgcc cgcgctggtg cggttgctgg ccgcgcacct
    13681 cggggtccgc gcgccgaagc tcaaggtgcc ggtggggctg ctccggcggc tgcccgccgc
    13741 ggtggcccgc gccgatcccg aaacgctgag cttcctgtcc gaggaccggt acgacacggc
    13801 ttcggcggag cggatcgcgg ccaccgccgg gttgtcgcat ccgccggtcg aaaccgcgtt
    13861 gcgccgctgg gccgaccgcc tggtcgcgga cggcttcggt gccgcaccgg ccgtgctgcc
    13921 tggcgggttc cacgaggtcg cgggctcgcg ggcgtatgtc gccggtgctc gcgtcgagcc
    13981 ggattacgtg ctgctgcaag gacttgagcc gagcgcggaa ccatggcggg agatcgtcgg
    14041 tgaactcggg tccgtgctga ccgccgatct tcccgggctc ggccggtcgg cacccagcgc
    14101 gctcgcgcca cacgactggc tcgccgagtt gctggctccc gtgcggacgc ggccggtcat
    14161 cgtcgcgcac caggccgcgg ccgagcccgt gcttcggttt gccgcggcac acccggaccg
    14221 gctggcgacc gtggtcctgg tgccacccgg gttcttcacc gccgggccgg tcgcggtgcc
    14281 gagccggccg ggtgccgccc gccgccgggt gcggtggcag cgggcggcgg ccgatccggc
    14341 acgggtgcgg gcccggtatg gcaccgtgcc ggtcgttttt gccgccagtg gcgcggaaat
    14401 cgtggccgcg ggcgaaggcc gtctcggtgc ggtcgggcac cgagacggcc tggggtcctg
    14461 atcagactcc ggcgacctgc tggatccagc tgcggtaccg ggtgatgttc gtgtacgcgg
    14521 tgttgttcga ccggtcgctg gtggaggcga cgccgacctg gcggccggag gcgaacatcg
    14581 ggccgcccga gtcaccgccg gcggtgatgc cgtcgatgcg gttggcgcac accgagatgc
    14641 cgccgtagta gtcactgcag ttgaccgagt tgacccgcac gttggcgtac ttcaggtacc
    14701 gcgactggca gttgatctcc gagccgcagc ggctggtcgc gccccagccg tagacctgca
    14761 cggtctggcc ggtggacacg tcgctggtgg tgccgagcgg ggagtaggtg gcgttgaccg
    14821 tggtggtcag ccggacgatc gccaggtcgg ccgaaccggg gtaccgggtg atggtgctgc
    14881 cggtggccat cgtgccgccg ctttgctggt ccaggctgcc gatccggaag gtgtaggtgc
    14941 cgctgctggc gacgcagtgc ttagcggtga ggatgtactg cggcgcgatg atcgtcgcgg
    15001 tgcaggtctg ccgtccgttc acgaacagcc gggccgccca cggcccgctc gtggcgtact
    15061 gaccgccgat gatgaacggc tgcacggtgc cgggctccgt ggcgggtgcc gcggtggacg
    15121 gggcggcgag gccgagcaag gccatcaggg cactgccgat gagcacggcc agagagcgca
    15181 agcgcatgat tccgactcgt ttctgcggca cgggtggtgc cgcgtttccg gggaggggat
    15241 gcgctcaatt ctgtgaccgg cacgcgcggc gctggaaccg acgaaagtcg ggtggtccag
    15301 accagcaata cctattcatc ggcggtggac gacctcggta taccgccggt gttatccgta
    15361 ccgttcggcc gtttggccga aggtgctcag atgcgggtca gcagggtgta cgcggcgacc
    15421 agcaggccgc cgcacagtgc ggcgagcagc aggacgcgca ggttcagggc gtcggtgggg
    15481 ttcgcggtgg aacggcgcat ggtggagcct ccggtgggtc ggcgccggct ggtgcgcggc
    15541 ggggccgtgg ggacggtcat gtcccgctga cctccgccgc cgggcctcgt gacggcggtt
    15601 cggccccgaa agcgcgaatc tcacctcggc gggtgatgcc ggggaggatc cagcgaggtc
    15661 agcacaggcg tgtgaccaca agtagcgaac cgatcactca aggtgtcagg tgtaattttc
    15721 cgccgccttt accgcatgcc gatgaaattt cgatgaaatg gccgggccac catttttgcc
    15781 accggcggca ttgttctgtt gtacagtttt ccggtggcag gcagattcaa gccgctgacc
    15841 ccggaagatc cgcgtgaagt cggcgggtac cggttgcgcg cgcgactcgg cgtcggcggc
    15901 atgggccggg tctacctggc gttcagcccc ggcggccggg cgctggcgat caaggtggtg
    15961 cgcaccgagc acgccgagga cgaggagttc cggcggcggt tccgtcagga gatcgccagc
    16021 gcccagcggg tgcagggcat ctacaccgcg caggtgatcg acgccgacgc cgaggcggac
    16081 gtgccgtggc tggcgacggc gtacgtgccc ggcccgtcgc tgcgcgaggc cgtggcggac
    16141 cacgggccgc tgccgcccga aacggtttcc cggctgctgg ccggggtcgc ggaagggctg
    16201 gccgcggtgc acgcgtgcga catcgtccac cgcgacctca ccccggccaa cgtgctgctg
    16261 gccgaggacg gcccgcgggt gatcgacttc ggcatcgcgc acgcggcggc ggccacctcg
    16321 ctgacccgca ccgggatgag catcggcacg ccggcgttca tgtcgccgga acaggtgcgc
    16381 ggccaggccg tgacggccgc caccgacgtg ttcgcgctcg ggcacctcgc ggtgttcgcc
    16441 gccaccggac ggcccgcttt cggtgagggc aaccgggacg cgttgttcta ccgcgtgctc
    16501 tccgaggacc cggacctgac cggctgcccg gaagccatcc ggccgatcgt ggcgcgctgc
    16561 ctggccaagg aacccggtga ccggccgtcg ctggaggagg tcatggcgga agcgggcgag
    16621 cacgccgacc tcaagctgtc cggcgactgg ctgcccgact cggtcaccga ggtcttcaag
    16681 cgcttcgaca ccgccttgta caccgtccac gaaggacaga aagaaccgaa accgcggaaa
    16741 ccaccgaaac cgccggagca aaaggaaaag cggagcgtgc cggtcggcgg cctgctcggc
    16801 gccgccacgc tggtcgcgat cctggtgatc ggctcgatcg gcccggacaa ggtgctgaac
    16861 gccgcggacg agttcttcgc cagcgccaaa tccaccagca ccaccaccaa acgcgccacg
    16921 accaccaaga agaccaccac gaccacgcgc acgcccgtgc gccgcgcgac caccgaacgg
    16981 accaccacca caaccaggac caccgaccgg aagagcaagc aggaagcctg ttcggccgcg
    17041 gaacgggcgt tcgacaagct ggagaacacc acgatcagct cggaccggca ggagaacgcc
    17101 gccgcgtacc gccgcctgtc ccgcgacctg gccgaggccg gggacggcgc gtcggactcc
    17161 accgtgcggt cgaagctgag caggctgtcc agcggttatt cgaccgcggc ggactacctg
    17221 tacgacgatc gccccggcgc gttctccacc ctcgccgccg acctcgactc ggacgcggac
    17281 gaactgcgcg acctgtgccg cggctgagtc gtcaggcttc gacggtgccg ggtggcaccg
    17341 ggtggtcggc ctgctgcacc cagacccgtt ccagccgccc gtccacgagg tcgtcgttga
    17401 gcaggtaagc ggggtcgtgg ccgagcaggt gggcgaccat gttgctgccc tcgctgcccg
    17461 gcggccgcag ccggaggtgc tcgaacacgc cccggctcgg gttcgccagc cagaagtgcg
    17521 gcgtcagcgg gtcgccttcg ggcaggtggt cccagccggt gacggtcacc gcgcagaaga
    17581 agtcgaactc gcgcccggcg tagaactcct cggcgtgcgc caggacccgg ccgaggtgcg
    17641 cggcggccgc ccgcaccagc acctggttcc gctccagcgg cggcagctcg tccaggaacg
    17701 agatctgccg gtaggtggcg tacaacggca gttcgtcgaa gtagccgtcg taggacatca
    17761 gcccgtcgaa gtcgagcagg tccccgtcgg ccagcaggcg gtcgaactcc gcgcggaacc
    17821 gggggtcgat ctcagcggtc accggggcct ccctccactt cggacgctat caccacgggt
    17881 gggtgcccgg gctctgcccg gcccaccggc cgctggtcgg ccaggcgaag ccgtggtcgt
    17941 aggcccattc gtaggtggcc cggttccagt tcggatcgcc gtcgtggaag gtgccgtcca
    18001 tgttcaggcc cggcgtgccg cggcccgcgc cctgcacgtg gtactggctg cccgggatgt
    18061 tgccctgcgg tgcgtcgacc cggccgccgc gcagctcgtt gggcaccgag cccacgtcgc
    18121 ggcggatgtc gctggccgcc tggcggacga gccgttcccg ttcggccgcc tgctgctcgg
    18181 cgatccggtc ggggtggttc tcggcgtccc ggtagagctg gttccaggcc tcgctgcggg
    18241 cctgctggtt ggccgggtcg ttcgggtcga ggtcgcgcag cgcccgctcg gcttcgtcgc
    18301 aggtcatcag gccgagcggg tcggtcagcc gcaacgggtt cgccacgtag gcgtgcgggt
    18361 tcggcgtgcc gagcaggccg agcgggtcat tgctctggta ccgcccggtt tccgggtcgt
    18421 agtaccggaa gtagttgtag tgcagcccgg tttcgtcgtc gtggtactgg ccggggaacc
    18481 gcaacggggt ggcggtccgc tgccgcagcg cgccgagcgc ctcaccccac agcgtggtct
    18541 gcgcgcgcca ggcgagctgc ccgctgtcgt cgaccagctc ggtcggcgtg ccgaccaggt
    18601 cggtcacgat ggcgtagaac cgccggtcga cctcgtcctg ctcgatctgc gtgaccgggc
    18661 ggttccggcc gtcgtagtcc caggtgaccg cttcgccgcg cgggccgatc tgctccgcga
    18721 cggccgcgcc gtcccagctg aacagcacct ggtcggccac cgagccgtcc tgggcgagcc
    18781 gctgcttggc gatccggcgg ccgagcgcgt cgtagcggta gcgccagtgc gtgccgtccg
    18841 gggtgatcac gccggtcagc cggtcctcgg cgtcccactg gtagtgccag gtgtccggct
    18901 tgcgggacag gcgcttcttc tgcttcagca ccacgcggcc ctgccggtcg taccggtacc
    18961 gcacgtcacc gctttcgtgc acgaccgtgc cgaccgccgc gggcgcgacc ggcacgtccg
    19021 gcacggacgg ctcgcggacc aggttgccgc tgaggtcgta ggcgtagcgc tcctgccagc
    19081 cggggccgtc cacggaggtg atccggccga ccgggtccag cccgaactgc cgcgtgccgc
    19141 cgagcgcgtc ctggaccgcg agcaccgcgt cgtccgcccg gtaggtgtag tgccgccgct
    19201 gcaccaggtt cgcctggcgc tggtacccgc tcacggtgct gatggtctgg ccgaccagcc
    19261 ggtgcttggc gtcccattcg ctggccatca ccagcccggt gtcgagcagg cgctcgacct
    19321 cgcggcccgc cacgtcgtag ccgaacgaca gcgtgcgccc gccgctgacc aggcgcgaag
    19381 cgcggcccag ccggtcgtac tcccaggtgc tctcctggcc ggccggggtc cgccggtgga
    19441 ccaggcggcc cgcggtgtcg tagcggtagg acatggtgcg gccgttgacc gtctccgcga
    19501 cgatccggcc gcccgcgtcg cgctgcatga ccacctcggc gtccgagttg accgcccgca
    19561 ccagcgcgcc cgcttcgtcg aattcgaagg tggacacgtt cgaggcggtg tgccgcgcgg
    19621 cgatgcggcc gagctggtcg cgcacgaagc tgatcgtctc gccctcgccg ttgaccatgc
    19681 cgaccagctg accggccgcg tcgtaggtgt agcggagttc gcggccgttg tagtcggtct
    19741 cgccgatccg gttgcccgcg gcgtcgtagt ggtaccgcca gaccagtccc gccgcgttgc
    19801 gcacggcgac cacctgaaga ttggtgtcgt actcgaattc ggtgcgcgcg ccggtggggc
    19861 cgaccaccgc cgagaccagg tcgaagtgcg tggtctcggt gtgcgtcgac tggccgagcg
    19921 cgtcgatgtg ctcgacccgc gcgccttcac cgtcgtagcg ccagcgctcg ccggtgccgt
    19981 cggggtaggt ccgcgccagc agcttgccct cgacggtcca ggtgaccgtg gaccggttgc
    20041 ccagcgcgtc gacgatggtg gacagcctgc cgaactggtc gcgggtgtac cgggtggtcg
    20101 cgccgagcgc gtcggtcacc gcgaccggca gccccgccgc gctgacctcg aggcgggtgg
    20161 tgttgccgag cggatcggtc ttgccgacca ggttgccgcg ctcgtcgcgg aggtaccggg
    20221 tgaccgcgcc ggtgggatcg gtggtggcca gcaggttgcc gcgctggtcg tagtcgtagc
    20281 gccacaccgc gccgcccgga tcgacctgcg tgacgggctg gccgaactcg ttgtactcgg
    20341 ccaggccctg gctgccgtcg ggccgggtca ccgtgaccag gttgccgttg tcgtcgtagg
    20401 tgaaccgggt gacgcgcccg agcgggtcgg tgcggaccac cagctcgtcg cggtcgttcc
    20461 actcctggcg cgtgacgttg ccgagcgggt cggtcagctc gaccacgttg cgggcttcgt
    20521 cgtagcggta ggtggtgcgg ttgccgagcg agtcggtgaa caccgtggtc agctcgccgt
    20581 agtcgaaggt gccgttgagg aaaccgcccg cgccttcgtt ggccacacac cggccgcgcg
    20641 cgtcgtagcg gtagccgtac caggtgccgg tgcggtcctc ccagcggacc aggcgcccct
    20701 cgctgtcgta gtcgaaccgc agtgccttgg tcgaggagtt gaacaccttg gcgaggcggc
    20761 cgcggtcgtc gtactcgtac cggacgacct cgatgtccgc cgactcgtcg gccagcagca
    20821 gccggttgat caggccgccg cgctgttcga cgagcacgcg gtagccgccg ctgtggtgca
    20881 gttcggccag cgcgccgtcc ggtgtgtagc cgagttcgat gcggttcccg ttgcggtcct
    20941 cgaccgcctc cagcctgccg cccgtggcga agcgcagcga ctggttcgcg tccggcttgc
    21001 tgatcaggta accgtcttcg gtcctggtca gcggccagcg cgggccgacg gcgggcagca
    21061 cgggggagtg gtcggacagc gggtcgggat aggtcagcag c
//
