LOCUS       NZ_LWAI01000046        21613 bp    DNA     linear   CON 07-APR-2024
DEFINITION  Priestia endophytica strain 3618_1C 3618_1C_contig_5, whole genome
            shotgun sequence.
ACCESSION   NZ_LWAI01000046
VERSION     NZ_LWAI01000046.1
KEYWORDS    WGS; RefSeq.
SOURCE      Priestia endophytica
  ORGANISM  Priestia endophytica
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Priestia.
REFERENCE   1  (bases 1 to 206893)
  AUTHORS   Lekota,K.E., Mafofo,J., Rees,J., Muchadeyi,F.C., Madoroba,E. and Van
            Heerden,H.
  TITLE     Comparison of Bacillus endophyticus and B. anthracis characteristics
            using whole genome sequence analysis and microbiological analysis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 206893)
  AUTHORS   Lekota,K.E., Mafofo,J., Rees,J., Muchadeyi,F.C., Madoroba,E. and Van
            Heerden,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-APR-2016) Biotechnology Platform, Agricultural
            Research Council, 100 Soutpan Road, Pretoria, Gauteng 0110, South
            Africa
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-MAY-2015
            Assembly Method                   :: CLC Genomics workbench v. 7.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 330.0x
            Sequencing Technology             :: Illumina HiScan SQ
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003269975.1-RS_2024_04_07
            Annotation Date                   :: 04/07/2024 05:04:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,413
            CDSs (total)                      :: 5,355
            Genes (coding)                    :: 5,223
            CDSs (with protein)               :: 5,223
            Genes (RNA)                       :: 58
            rRNAs                             :: 1, 1 (16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 44 of 132
            Pseudo Genes (incomplete)         :: 88 of 132
            Pseudo Genes (internal stop)      :: 43 of 132
            Pseudo Genes (multiple problems)  :: 35 of 132
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:25:48
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 21613
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LWAI01000046.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21613
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..21613
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21613
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[<4:1613](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <5..1613
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     gene            <1..1613
                     /locus_tag="A4U60_RS18120"
                     /old_locus_tag="A4U60_17960"
     CDS             <5..1613
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: PCP (197-265). E-value: 7e-22. Score:
                     69.4. Matches aSDomain: nrpspksdomains_A4U60_RS18120_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (284-508). E-value:
                     3.4e-31. Score: 101.4. Matches aSDomain:
                     nrpspksdomains_A4U60_RS18120_Thioesterase.1"
                     /codon_start=3
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001255753.1"
                     /locus_tag="A4U60_RS18120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_17960"
                     /product="thioesterase domain-containing protein"
                     /protein_id="WP_142674267.1"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-47, bitscore:
                     155.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7e-14, bitscore:
                     45.8, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 5.4e-27, bitscore:
                     89.0, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VTIGRPLPNVQVYVLDRNLLPVPIGVTGELYIGGAGIARGYLNRP
                     ELTAERFIRHPFNEEERLYRTGDLVRYLTDGHLEYLGRIDNQVKIRGFRIELEEVEANL
                     ESHPLVKEAVVLVTEDKPGEKRLVAYVVGEGSMHEWREHLKTQVPNYMVPAHFIEVEAI
                     PLTTNGKVDRKALNSLTIQRENNFSTPIIPRDEIEYQLIKIWQDLLQIEDVYVNDDFFN
                     RGGHSLLVIKLISKIRETFGKEIKVSTLIKNPTVEGISCLIRDKHDMTKSLSTLVPLQE
                     SEKRPFFCIHPFMGNVFCYIQLARLLKNHCSFYGLQNPLVEKRQMDGLTLSEVVQLYIE
                     EIKCVQPEGPYRLGGWSLGGAIAYKIATVLRNQGKEVELLVLMDTKVPSEQDHKTKEDV
                     ISYITKNFIHFDQVEQGEELVHQQDILVDRLIVEGVLPPDADLTSLKQIANAHRKCLNL
                     MAKDVLTPYSGEVIYFSAEEGIELFTDWQPLLRGKVNKYLIPGSHEEIVFSPAVEKISK
                     YLVNKLEGIKGVDFLLARK"
     CDS_motif       72..161
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4U60_RS18120_0001"
                     /evalue="4.10E-20"
                     /label="NRPS-A_a6"
                     /locus_tag="A4U60_RS18120"
                     /protein_end="52"
                     /protein_start="22"
                     /score="63.8"
                     /tool="antismash"
                     /translation="PIGVTGELYIGGAGIARGYLNRPELTAERF"
     CDS_motif       243..308
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4U60_RS18120_0002"
                     /evalue="5.50E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="A4U60_RS18120"
                     /protein_end="101"
                     /protein_start="79"
                     /score="37.6"
                     /tool="antismash"
                     /translation="YLGRIDNQVKIRGFRIELEEVE"
     aSDomain        597..800
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4U60_RS18120_PCP.1"
                     /evalue="7.00E-22"
                     /label="A4U60_RS18120_PCP.1"
                     /locus_tag="A4U60_RS18120"
                     /protein_end="265"
                     /protein_start="197"
                     /score="69.4"
                     /tool="antismash"
                     /translation="EYQLIKIWQDLLQIEDVYVNDDFFNRGGHSLLVIKLISKIRETFG
                     KEIKVSTLIKNPTVEGISCLIRD"
     aSModule        597..1529
                     /domains="nrpspksdomains_A4U60_RS18120_PCP.1"
                     /domains="nrpspksdomains_A4U60_RS18120_Thioesterase.1"
                     /final_module
                     /incomplete
                     /locus_tags="A4U60_RS18120"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        858..1529
                     /ASF="active site serine present: True"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4U60_RS18120_Thioesterase.1"
                     /evalue="3.40E-31"
                     /label="A4U60_RS18120_Thioesterase.1"
                     /locus_tag="A4U60_RS18120"
                     /protein_end="508"
                     /protein_start="284"
                     /score="101.4"
                     /tool="antismash"
                     /translation="RPFFCIHPFMGNVFCYIQLARLLKNHCSFYGLQNPLVEKRQMDGL
                     TLSEVVQLYIEEIKCVQPEGPYRLGGWSLGGAIAYKIATVLRNQGKEVELLVLMDTKVP
                     SEQDHKTKEDVISYITKNFIHFDQVEQGEELVHQQDILVDRLIVEGVLPPDADLTSLKQ
                     IANAHRKCLNLMAKDVLTPYSGEVIYFSAEEGIELFTDWQPLLRGKVNKYLIPGSHEEI
                     VF"
     CDS_motif       861..890
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4U60_RS18120_0003"
                     /evalue="2.20E-02"
                     /label="NRPS-beforete1"
                     /locus_tag="A4U60_RS18120"
                     /protein_end="295"
                     /protein_start="285"
                     /score="8.0"
                     /tool="antismash"
                     /translation="PFFCIHPFMG"
     CDS_motif       1041..1115
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4U60_RS18120_0004"
                     /evalue="5.10E-14"
                     /label="NRPS-te1"
                     /locus_tag="A4U60_RS18120"
                     /protein_end="370"
                     /protein_start="345"
                     /score="44.5"
                     /tool="antismash"
                     /translation="QPEGPYRLGGWSLGGAIAYKIATVL"
     gene            2092..2798
                     /locus_tag="A4U60_RS18125"
                     /old_locus_tag="A4U60_17965"
                     /pseudo=""
     CDS             2092..2798
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012259872.1"
                     /locus_tag="A4U60_RS18125"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="A4U60_17965"
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEKQNLFMWKHYQPDIILLTVRWYLRYNLSFRDLVELMEGRGLSI
                     AHTTIMSWVHQYGPELGERVRRRLS"
     gene            3199..3834
                     /locus_tag="A4U60_RS18130"
                     /old_locus_tag="A4U60_17970"
     CDS             3199..3834
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.4"
                     /locus_tag="A4U60_RS18130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_17970"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_061805665.1"
                     /sec_met_domain="HAD_2 (E-value: 9.3e-35, bitscore: 113.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTVIFDFDGTIVESGQVVFDLFNSFADKYKYTKMPQEESDYIR
                     TITFKERFKKFNVPLWKIPMLTIDIVKKYKEEIPHLEPIGDIKSVLKTLKESGFQLILV
                     SANSQENIKKFLKLNDMDYFDEILRSHRFFGRHITLNNYVKSHNVQRENIVFVGDEHRD
                     IIACKKSDIKIISVTWGYDFEVLLQEAQPDYIVKEPLDIVRTIEGINK"
     gene            3831..5195
                     /locus_tag="A4U60_RS18135"
                     /old_locus_tag="A4U60_17975"
     CDS             3831..5195
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="A4U60_RS18135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_17975"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_113753782.1"
                     /transl_table=11
                     /translation="MIALFLVSAIFAILCYRYDPKSPSLRWVVFLLICSSLAGLSRAII
                     ESFIPALNKNDMNFDLLNTFLYGLRIFTGFVSIYFCPYGILMHAVVYSGRFTSKVIRTL
                     KYILLIPIPFMVDTTVYVPDIVPDFDSMLYWAVPYICIACIIHIYAYMTEKDEKKKKSR
                     FITLSLMFPVILTALILNYIVRAFNSSNQIWRYVVFFLVISFFIFIWKALGSGSLNGIK
                     LRYEREAREKTSKAVTSGTSLLNHSIKNQIYKINSSLQIIQPHSHNLDASCQKAVEIIN
                     KSSNHLIEMVDRMQSQTQEIQVKKSNCDLSELMDETLNYVQKEIEAKGITVEKVYEPNI
                     YAYCDSTHTKEVFLNIIKNSIESMDRSGNIRVVITKGAGNQITVSFTDDGSGISEENLR
                     HVTEPFFTTKGRRGTNFGLGLHYCYDVMLKSNGNLHIESELNKGTTVTLTFPLKG"
     gene            5201..5827
                     /locus_tag="A4U60_RS18140"
                     /old_locus_tag="A4U60_17980"
     CDS             5201..5827
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.4"
                     /locus_tag="A4U60_RS18140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_17980"
                     /product="response regulator transcription factor"
                     /protein_id="WP_061805667.1"
                     /transl_table=11
                     /translation="MNPIRVVLIEDDIDWLNIMETIIGNEDDIVLVGCGTTKEEAINLS
                     NALDHIDIFLVDINLTDNNLDGIYTALELKSSGDWKVLMLTSMSDEDIIQKSFIAGATD
                     YILKKDVHKIPHIIRSIYHEPSNPVEVILQDYRRMKSEEQLKDLTNAEREVYKLIEQGH
                     SRRDIQKKLMKSDNTLKNQIKNILKKMSVSNSKEAIRKVKSGGLW"
     misc_feature    complement(6101..6116)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.1"
                     /tool="antismash"
     gene            6160..6417
                     /locus_tag="A4U60_RS18145"
                     /old_locus_tag="A4U60_17985"
     CDS             6160..6417
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391034.1"
                     /locus_tag="A4U60_RS18145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_17985"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_113753783.1"
                     /transl_table=11
                     /translation="MEEINIIRAKRMKKRWTQLELAKVSGVPQCTISQLERGNRKYPTY
                     ETIRKIAKALDLTLEEIYLLQDHKEKGVVKEEEGKAPAFL"
     gene            6436..7191
                     /locus_tag="A4U60_RS18150"
                     /old_locus_tag="A4U60_17990"
     CDS             6436..7191
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014581.4"
                     /locus_tag="A4U60_RS18150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_17990"
                     /product="type IV secretory system conjugative DNA transfer
                     family protein"
                     /protein_id="WP_113753784.1"
                     /transl_table=11
                     /translation="MKTDKIKKSATTSGGIEEKASCSLEEHKHVLVIGEVATGKTSTYI
                     LPNILGEKEKSLLVFDPRGTRYHFTQEEKREQGYIVKDYPVLSLDKETIKHIAQMLVKE
                     KTVVYLHFDHREGDKEKEETFTNLINTLYEAIEEQGFYHKGIHVLMDEAQAYKVPHLPL
                     FLAAGRKYNVNFSLTVLHLSSLRDLYGEEATQQMIKYSVKGLFGTRSQEDAEYFASFIE
                     GPFTKEECNAHYLFSLPREVPVWLLPSSH"
     gene            7525..8166
                     /locus_tag="A4U60_RS18155"
                     /old_locus_tag="A4U60_17995"
     CDS             7525..8166
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391036.1"
                     /locus_tag="A4U60_RS18155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_17995"
                     /product="restriction endonuclease"
                     /protein_id="WP_113753785.1"
                     /transl_table=11
                     /translation="MANSVFIFIIFFLLIVLFQLMRYVYRTLLKRQALRRLMQSGIPYI
                     DQMDGFQFKMYLKALFQQLGYKAQLAPQSGDAGADLIMKGKKKIVIQAKRYGVNNKVSQ
                     SAVQEVYSAQAYYEADEAWVMTNSFFTKQAKVLAEVCHVQLFDRHALQTLILEVNPIHT
                     AEDIYREVKPEPRTCPVCENLLIIRHRNGERFFRCVSFPQCEHTEAINKE"
     gene            8802..9692
                     /locus_tag="A4U60_RS18160"
                     /old_locus_tag="A4U60_18000"
     CDS             8802..9692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391037.1"
                     /locus_tag="A4U60_RS18160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18000"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_113753786.1"
                     /transl_table=11
                     /translation="MNLLKNMNGALQYIEENLTNDVDFREVARRAFCSEYHFKRMFSFL
                     AGITLSEYIRRRRLTLAAFELKNSNMKVIDVAIKYQYNSPDSFTRAFQNLHGITPSEAK
                     KNGHSLKAYPRMTFELSIKGGNEMNYRIEEKEAFCIVGIKERVPIIFHGVNPHIAAMWE
                     SLNDETINKLKKLSNVKPLGLLSASVNFSEGRMEEKGELDHYIGVATTKECPDNLRQLE
                     VPALTWAVFEAVGPFPDTLQDVWGRIYSEWFPSSNYEQVEGPEILWNEHKDVTSPTFKS
                     EIWIPVLKNNDGREL"
     gene            complement(9796..10791)
                     /locus_tag="A4U60_RS18165"
                     /old_locus_tag="A4U60_18005"
     CDS             complement(9796..10791)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391038.1"
                     /locus_tag="A4U60_RS18165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18005"
                     /product="DUF3231 family protein"
                     /protein_id="WP_113753787.1"
                     /transl_table=11
                     /translation="MQENNHLTSSEISNLWAHYIRETLSVCVNKYMVQTIQDPEIHHLF
                     QSALKISSQHIETLKNLFRQEKFPIPNGFTEEDVDLKAPPLFTDVLCLKYLHIMTTHGL
                     NEYSLSFTASIREDIVEFYQQCNLDAMEIYKKAKDLLISKKLYQQPPTYVTPKKVKIIK
                     NYKYVTNILGKRRPMNSIESGHIYFNLSKAITAKAIMLAFKQVAKDPTVCTLLEKSLQV
                     KNKHIEGFSSLLIKDNLHLPQTLETEITNSTVSPFSDKLMLLQTGFLFGVAVTYYNASV
                     ISSMRADISVHCEKAGLNSLWIYSRIGKSMIDHKWMEEPPRAEDRKKLDD"
     misc_feature    complement(11080..11096)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.64"
                     /tool="antismash"
     gene            11223..12854
                     /locus_tag="A4U60_RS18170"
                     /old_locus_tag="A4U60_18010"
     CDS             11223..12854
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391039.1"
                     /locus_tag="A4U60_RS18170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18010"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_113753788.1"
                     /sec_met_domain="DAO (E-value: 3.4e-10, bitscore: 33.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHKYTPVLIVGGGLSGLTSALFLARHNIDYLLIEKHTSTAIHPK
                     AGGITFRTMELFRQLGLESAIRTASKPLEHIRGRIAVETLQNIDLAELKKVESVQKATD
                     EKIAKRIEKISPSKAASCYQTEIEPILLQAIEQRKGHIRFNTELIEYQQDDLGVTATIR
                     DRETGTEEIIQSDYLVAADGAKSSIRKHTNIPTTGRGVIGGHYMNIHFRANLSHFLKGS
                     QFGFYQILNPEAFGALITVNNCDEWIYHVAYDPSKGQCPEDFSEDECYKIIKKAIGVSN
                     LDIVILSILPWAAVEKTATCFWDKRVFLVGDAAHLMPPTGGFGSNTGIQDAHNLAWKLA
                     AVIRKQAHPRLLQTYHDERHHVVKETTKYASDLLFRAMNKGVSNLNNMDHLAITVGYKY
                     SSGAIIEEKLNTHRMDRLELEGQPGTRAPHMWLKYQDKYISTLDLIGENFVLLTGEDNR
                     CWRTAAEDVASHLGIFINVYGIGSESDLVECEGNWEAVYNVSSQGAVLIRPDGFVAWRT
                     KERILNPNLILKQVMTTILGQDSETI"
     gene            complement(13181..14521)
                     /locus_tag="A4U60_RS18175"
                     /old_locus_tag="A4U60_18015"
     CDS             complement(13181..14521)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391040.1"
                     /locus_tag="A4U60_RS18175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18015"
                     /product="APC family permease"
                     /protein_id="WP_113753789.1"
                     /transl_table=11
                     /translation="MNNSTKQVAPERQLRMKHVVAIGFAYMAPFAVFDTFGIVSHVTNG
                     LVPLAYFIVFISILFTALSYRKLVQKYPISGSVYLYTKRIIHPYAAILVGWVSFIAYLA
                     LPMINALLASVYLSSGFPNVPKWVWVISLITFITLMNCIGIKIATTLNTWLVILQFIVV
                     IVFIGLCLKDLLTTPAQSMPIHDLLPTPNEFPTLLPGAALLTLSFVGFDAITNLCDETI
                     RPEKTIPKAIILLAIGGLVFFVTVTYLMQSLFPNASQFNNYEAASPEIAVHLGGNLFLA
                     FFLGAALLSCIASGLASQLVASRFLYAMGRDGALPKRVFSYLHPRSKTPIFNILIVGLL
                     AATALFLDLEKATALVNFGAFSAFTFVNICVLYAYFKRKKKPAFFENFLFPFLGLVFTG
                     FLWISLNPFSLFIGGIWTLLGIVYLISTTRFFKKAPVDLHYDELSGM"
     gene            complement(14537..16006)
                     /locus_tag="A4U60_RS18180"
                     /old_locus_tag="A4U60_18020"
     CDS             complement(14537..16006)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391041.1"
                     /locus_tag="A4U60_RS18180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18020"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_113753790.1"
                     /sec_met_domain="Aldedh (E-value: 1.4e-190, bitscore:
                     627.3, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNITKEVLDFLEEPKTLFINGEWYSSPMTGTFETFNPATGELLA
                     RVAEATKEDVDRAVYAARSAFEHGEWARMDGSIRGQYLYKLANLMERDIRILAEIDTLD
                     NGKPIAEMLGNDLPNAIEQLRYYAGWTTKWGGQTIPISPQYFTYTQHEPVGVVGQIIPW
                     NFPIMMAIWKIAPALATGCTVVLKPAEQTPLSALYLAKLIEEAGFPKGVVNIINGKGSI
                     TGEALVQHPDVDKIAFTGSTAVGKAIMQKAAQTLKRVTLELGGKSPNIILPDADLTKAI
                     PGVFSGIMANQGQVCCAGSRVYVQKDSYDLVVQELKHYAENVKLGNGLEEDTEMGPLVS
                     KKQQDTVLSYIEKGVNEGATLLAGGQKLAKGCFITPTVFTDVDDEMTIAKEEIFGPVVV
                     VIPYDTLGDVVSKANNSIYGLAAGIWTENVKNAHQLASKLKAGTVWVNCYNLTNAAVPF
                     GGYKQSGYGREMGSYALENYTEVKSVWVNLD"
     gene            complement(16020..17390)
                     /locus_tag="A4U60_RS18185"
                     /old_locus_tag="A4U60_18025"
     CDS             complement(16020..17390)
                     /NRPS_PKS="Domain: Aminotran_3 (35-381). E-value: 3.8e-96.
                     Score: 314.0. Matches aSDomain:
                     nrpspksdomains_A4U60_RS18185_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391042.1"
                     /locus_tag="A4U60_RS18185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18025"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_113753791.1"
                     /sec_met_domain="Aminotran_3 (E-value: 5.9e-98, bitscore:
                     321.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQTLYTLAELDKQHILHPSTSPAFNRNNGPAIIFERGEGLHIF
                     DMDNNKYIDGVSMLWNVNVGHGNKELALVSFDQMQKLAYSSMFYGYSNEPAVKLAEKIT
                     SMTPGDLDSVFYTSGGSESNDTAFKLARFYWERKGLANKKKIISLKRGYHGVTVAAQRA
                     TGIEVYRAFSGSGDPDIINAEPHLTSCELGDINHPSYQNSIRGTIEREGANHVAAVIIE
                     PIQGAGGVHVPPEDYLQAVRKLCDEQNILLIADEVICGFGRTGRSFGVNHWDIVPDFMS
                     VAKGITSGYAQLGAVVMRTPIMDAICEVPDMLAHGFTYSGHPTACAVGLKNLEIIEREN
                     LIDQADQMGKLLLKGFDYLSDKYHFFHNGRGRGLLTGFDLMKDPEQNITFTPEEAAAMS
                     IVEECKKRGLLIRGFDFEPGMNIVAIAPPLISQQEDIETIISIVDESLSAYSKRLGL"
     aSDomain        complement(16248..17285)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4U60_RS18185_Aminotran_3.1"
                     /evalue="3.80E-96"
                     /label="A4U60_RS18185_Aminotran_3.1"
                     /locus_tag="A4U60_RS18185"
                     /protein_end="381"
                     /protein_start="35"
                     /score="314.0"
                     /tool="antismash"
                     /translation="FERGEGLHIFDMDNNKYIDGVSMLWNVNVGHGNKELALVSFDQMQ
                     KLAYSSMFYGYSNEPAVKLAEKITSMTPGDLDSVFYTSGGSESNDTAFKLARFYWERKG
                     LANKKKIISLKRGYHGVTVAAQRATGIEVYRAFSGSGDPDIINAEPHLTSCELGDINHP
                     SYQNSIRGTIEREGANHVAAVIIEPIQGAGGVHVPPEDYLQAVRKLCDEQNILLIADEV
                     ICGFGRTGRSFGVNHWDIVPDFMSVAKGITSGYAQLGAVVMRTPIMDAICEVPDMLAHG
                     FTYSGHPTACAVGLKNLEIIERENLIDQADQMGKLLLKGFDYLSDKYHFFHNGRGRGLL
                     TGFDLM"
     gene            complement(17409..18656)
                     /locus_tag="A4U60_RS18190"
                     /old_locus_tag="A4U60_18030"
     CDS             complement(17409..18656)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391043.1"
                     /locus_tag="A4U60_RS18190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18030"
                     /product="M20 family metallo-hydrolase"
                     /protein_id="WP_113753792.1"
                     /transl_table=11
                     /translation="MNGLNINQQRMLQSIKESSAIGATPNGGLHRLALSIDDKQMRNLL
                     INWFEEEGLSIRVDDFGNMYGRREGKSHHQMPIVIGSHLDTQPCGGRFDGILGVLAALE
                     VVRSLNEANVQTDHPIEIINFTNEEGARFEPPMLGSGGVCGVFEKDFIYSRQDKDGIKF
                     HDALSGIGYKGLKENRLQKAEYFIELHIEQGPILEEEQLEIGVVEGIQGISWISITVEG
                     EMNHAGPTPMENRKDAVVAAAKMIESIDKLAQEYEGLKTTVGQLNVYPNVPNVISGKVE
                     FIVDIRHEEDEQRERALEVMKQQLSTISGLCNVELTFHTSWENDSVTFSEKVIETISKC
                     AEKRNLSTKRMFSGPGHDAKYMAEIAKTGMIFVPSHRGISHNEEEFTRDDDLVNGANLL
                     LDVVCQLSGAKIPKTI"
     misc_feature    complement(18690..18703)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     misc_feature    complement(18730..18744)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 25.53"
                     /tool="antismash"
     gene            18815..20212
                     /locus_tag="A4U60_RS18195"
                     /old_locus_tag="A4U60_18035"
     CDS             18815..20212
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008134 - transcription factor binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1112: sigma-54
                     dependent trancsriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391044.1"
                     /locus_tag="A4U60_RS18195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18035"
                     /product="sigma 54-interacting transcriptional regulator"
                     /protein_id="WP_113753793.1"
                     /transl_table=11
                     /translation="MSPTFLSSEIKMMLDQLKDGIYIANKNGVTLWINQTSEKQLGVKR
                     KDIIGKTADELEARNLFTPSVTKIVLKKRKTISKAQTSKGIQYLATGSLIELEETGEEY
                     VIVHVKDISEMVKNAFKLKKAETLMSQYWNELQKMKSEKRDRTGEKRLIGTSDAHNEVM
                     DLLRRVANFDATILLQGETGVGKSVFAKEVHVLSDRRNQPFVQVNCGALPANLIESELF
                     GYKKGAFTGANSRGKTGLIEEASGGTLFLDEIGEFPLELQPKLLQFLQDKSFLPIGSTV
                     LQHSDTRIITATNQDLLQLVKEKRFREDLYYRLNVIPIEILSLKERREDILPLAHHFLQ
                     TYNYKYQRNVVLSKEVQPFFYRYNWPGNIRELENLIERLVITVRQEKILENDLPYHMLK
                     TNDEPASLGAEEEELQGKSLSEYLDSIERKMILKAYSKYKSTRKMAEKLGLTQSAVVRR
                     MKKYDIS"
     misc_feature    20255..20271
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.73"
                     /tool="antismash"
     misc_feature    20256..20269
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            20317..21435
                     /gene="aguA"
                     /locus_tag="A4U60_RS18200"
                     /old_locus_tag="A4U60_18040"
     CDS             20317..21435
                     /EC_number="3.5.3.12"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0047632 - agmatine deiminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009446 - putrescine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aguA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019391045.1"
                     /locus_tag="A4U60_RS18200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4U60_18040"
                     /product="agmatine deiminase"
                     /protein_id="WP_113753794.1"
                     /transl_table=11
                     /translation="MSLSITNSTPKKDGFRMPGEFEQHAGTWMLWPVRTDTWRNGAKPA
                     QQVFAKVVSTISEFEPVTVGVNAEQYENARAMLPHHVRVVEISSNDAWMRDIGPTFVKN
                     EEGVIRGINWGFNAWGGLQGGLYFPWDLDLMVKKKVLEIENKDWYECTEFILEGGSITV
                     DGEGTLITTEQCLLNKNRNPHLSKSEIEDKLKEYLNIEKVIWLKDGLIGDETDGHVDDL
                     AFFVRPGEVAIGWTEDVNHPQYHVHQEAYKILKEATDAKGRSLTIHKIELPNELILSKE
                     ASENIDFASSSYKREEGMPFVATYINCYLCNGAVIVPSFDDPSDDKARKKFEDIYPDRK
                     VILIDTRELPIAGGNIHCITQQQPASTSQKNY"
ORIGIN
        1 gggtaaccat tgggcgtccg ttgccgaacg ttcaagtcta tgtattggat agaaatttgt
       61 tacctgttcc aattggtgta acgggtgagc tctatattgg tggggcaggt atagcgagag
      121 gatacttgaa tcgcccagag ttaacagctg aacgatttat tcgtcatcca tttaatgaag
      181 aggaacgatt atatcggacg ggagatttgg ttcgctattt aactgatggc catttagaat
      241 atctgggaag aatcgataat caagtgaaaa ttcgaggctt ccgaattgaa cttgaagagg
      301 ttgaagcgaa tttagaaagt catccattgg tgaaagaagc agtagtcttg gtaacagagg
      361 ataaaccagg agagaagaga ttggtcgcct atgtagttgg agagggaagt atgcatgaat
      421 ggcgtgaaca tcttaagaca caagtaccga attatatggt tcctgcacac tttattgagg
      481 tagaagcgat tccgctcaca acgaatggga aggttgatcg aaaggcattg aacagcttaa
      541 ctattcaaag agaaaataac ttctctacac caatcatccc aagggatgaa attgagtatc
      601 agctgattaa aatctggcag gatctgctac agatagagga tgtctatgta aacgatgatt
      661 tctttaatag aggggggcat tctctccttg taatcaaatt gatttcaaag attagggaga
      721 catttggaaa agagattaag gtgtccacac tgattaagaa tccaacagtg gaaggaattt
      781 cctgcctcat tcgtgataag catgatatga caaaatcttt atcgactctg gttccactac
      841 aagagtcaga gaaaaggcct ttcttctgta ttcatccgtt tatggggaat gtattctgtt
      901 acattcaact agcaaggtta ctcaaaaacc actgctcatt ttatggtcta cagaatcctc
      961 tagtagagaa aagacaaatg gatgggttga ccttgtcgga agtagttcaa ctctacatag
     1021 aggaaataaa gtgcgttcag ccagaaggac catatcgtct gggaggttgg tctttgggtg
     1081 gggccattgc ctataaaatc gcaactgtac taagaaatca aggaaaagaa gttgagttgt
     1141 tggtacttat ggatactaag gtgccttcag aacaggatca caaaacaaag gaagatgtga
     1201 tctcttatat aactaaaaat ttcattcatt ttgatcaagt agagcaggga gaagaacttg
     1261 ttcatcaaca ggatatactt gttgatcggt taattgtgga aggagtgctc ccgcccgatg
     1321 cggatcttac gagtttaaaa caaattgcca atgctcacag gaaatgtcta aatttaatgg
     1381 caaaggatgt tttaacgcca tattctgggg aagtgatcta ctttagtgct gaagaaggta
     1441 tagagttgtt tacggattgg cagcctttat tacgggggaa agtgaataag tatttgattc
     1501 ctgggtcgca tgaagaaata gtcttttccc cagctgtgga aaagatatct aaatatctcg
     1561 taaataaatt agaagggata aagggggttg actttttgtt agctcgaaag tagagaatcc
     1621 agaaagataa aactttatga acacaaattg tcactatcaa agttgttatt tgtgagtaat
     1681 gatgtaaatg taaaaaggca tcccaataac tatacattga gtttatgaaa ttacgagtat
     1741 atcaagtgcg gaactatagg gttctggtgc aaaaattgct tgatagagac atggaaactt
     1801 acatggactg ttaaataaca tagtataatg caattaccct gaagtttttg catcaaaact
     1861 gaattttttt atgatgtcgt tgaagagaag gtgtatattt tcattaatat gtcaatatac
     1921 actttttctc ctttatataa ccttgaatat aagcaaaata taatttaaat agactctcga
     1981 aataaataag gaatttatcg ggttctggtg caaaaacttc aagatatctg caagtaatct
     2041 cccaaacttg aacatactga tactagtatt ctaaagaagg acgtgattag tatggaaaag
     2101 caaaatctat tcatgtggaa acattatcaa cctgatatta ttttattaac ggtgagatgg
     2161 tatctacggt acaacctcag ttttcgtgat ttagtcgagt taatggaagg acgcggacta
     2221 tctattgctc atacaaccat catgagctgg gttcatcagt atggtcctga attaggtgag
     2281 cgagtacggc gtcgcctaag ctaaccaatg attcttggcg agtcgatgag acgtatgtga
     2341 aggtcaaagc gtaatgggta tacctatatc gtgctgttga ttcagaaaga aatacgatta
     2401 atttttattt aagtaaaaca agagatcatc aggctacaaa gcgctttttc aagaaagctt
     2461 tgcggccttt ttatgtttta aagccccgtg ttatcacagt agacaagaac ccagcctatc
     2521 ctatagcaat tgaagaattg aagaaagaga aaaagatgcc cgtatgcatc caaataagac
     2581 aggtgaaata tcttaataac atcgtggaac aagaccatcg ttttattaaa aagagagttc
     2641 gtgcgatgtt aggattgaaa tcttttcgta cagccaagaa tattttgagt ggaatagaag
     2701 cgatgcatat gatcaaaaag aagcaagttc accaagggat gaagtctgcc caaaatcaaa
     2761 aagaattcat tcataaattg tttggattag cttcataagc tagcaattta aaggaaattg
     2821 atattctatg tttctagcga gtagtttttg caccagaacc ctaataaact cgaggtataa
     2881 aagtagtcca tttgtttgtt ctttttgtaa ttaaccactt caataagctg accaaaggtt
     2941 ttaatccatg ttacatctac gatttgattt ttttagtgtt aattttaatt cttccttata
     3001 ttattaaatg aacaatttgg ctaatgaatc attttttatt taacttccta tagaggagag
     3061 aactttagta cctgttaaaa gaatttctcc aaacaatagt agattatttt aacagaatta
     3121 aaaggagaat atggtattat aaatatataa tgtaagttct gtttaaacat agaagaatta
     3181 tgaaagtgga tgtgaaaaat gattaaaaca gtaatttttg attttgatgg aacaattgta
     3241 gaatcagggc aagtagtatt tgatcttttt aatagttttg cagataaata taaatacact
     3301 aaaatgcccc aagaagagag tgattatatc cgtactatta cttttaaaga acgatttaag
     3361 aaatttaatg ttcctctatg gaagatcccg atgttaacaa ttgatatcgt gaagaaatat
     3421 aaagaagaga tcccacattt agaacccatt ggtgacataa agtctgtttt gaaaacatta
     3481 aaagaatcag ggtttcagtt aatattagtt tctgcaaatt cgcaagaaaa cattaaaaaa
     3541 tttttaaaac taaatgacat ggattatttt gatgaaattc tcagatctca tcgcttcttc
     3601 ggtcgccata tcacacttaa taattacgtg aaaagtcata atgttcaacg agaaaacatt
     3661 gtatttgttg gtgatgaaca tcgggatatt atcgcttgta aaaagagtga tattaaaatt
     3721 atctctgtta catgggggta tgactttgag gtgctattgc aagaagccca accagattat
     3781 atagtgaagg aacctttgga cattgtaaga actattgaag gaatcaataa atgattgctt
     3841 tattcttagt tagtgctata tttgctatcc tttgttaccg ctatgatcct aaatcgccct
     3901 cattaagatg ggtcgtattt ttgctaatat gttcatcatt agctggttta tcgcgtgcaa
     3961 ttatagaatc atttatccct gccttaaaca agaatgatat gaactttgat ttacttaaca
     4021 cttttttgta tggtctaagg atttttacgg gctttgtatc tatctatttt tgtccttatg
     4081 gaatcttaat gcatgcagtt gtttatagtg ggaggtttac atctaaagtt ataagaactt
     4141 tgaaatatat tttgttaatt ccaatccctt ttatggttga cactactgta tatgttccag
     4201 acattgtccc tgattttgat tctatgctct attgggcagt tccttatata tgtattgcgt
     4261 gtattatcca tatttacgca tatatgacgg agaaagatga gaaaaagaag aagagtcgtt
     4321 ttattacctt gtctctcatg tttccagtta tattaacggc cttaatttta aactatattg
     4381 tacgagcttt taatagtagt aatcaaattt ggcgatacgt tgtgtttttt cttgtaatct
     4441 cgttttttat ttttatatgg aaagctctag ggagcggctc attaaatgga attaaattac
     4501 gttatgaaag agaagcgaga gaaaaaacaa gtaaagccgt tacttcagga acaagcttat
     4561 taaatcattc tattaaaaac caaatctata aaatcaattc aagcctgcaa attatacaac
     4621 ctcacagtca caatcttgat gcctcgtgtc aaaaggcagt tgagattatt aacaaaagct
     4681 ctaatcattt aatcgaaatg gtcgatagaa tgcaaagtca aactcaagag attcaagtta
     4741 aaaaaagtaa ctgcgattta agtgaattaa tggatgaaac tctaaattat gtgcaaaaag
     4801 aaattgaagc aaagggtata actgtagaaa aggtgtatga acccaatatt tatgcttatt
     4861 gcgatagtac tcatacaaaa gaagtgtttt taaacataat taaaaattca atagagtcaa
     4921 tggatagaag cggtaatata agggtagtca ttactaaagg cgctggtaat cagattacgg
     4981 tttcttttac ggatgatggt agtggtatat cagaagaaaa tctaagacat gtcacagagc
     5041 ccttttttac aacaaaaggg agaagaggga caaactttgg tttaggttta cattattgct
     5101 atgatgtaat gttaaaaagt aatggtaatc tacacattga aagtgaacta aataagggaa
     5161 caactgtgac gctaacgttc ccattaaaag gatgatgctt atgaatccca ttagagtagt
     5221 tcttattgaa gatgatattg attggttaaa tattatggaa acaattatag gaaatgaaga
     5281 tgatatcgtt ttagttgggt gtggcactac aaaggaagaa gctattaact tatcgaatgc
     5341 tcttgaccat attgatattt tccttgtcga tattaatcta acggataata acttagatgg
     5401 aatttacaca gcattagagt taaagagtag tggtgattgg aaagtattaa tgttaacgtc
     5461 aatgtctgat gaagatatca ttcaaaagtc attcattgca ggggcaacgg attatattct
     5521 aaaaaaagat gtacataaaa taccacatat tatccgttca atttatcatg aaccatctaa
     5581 tccagttgaa gttattttac aagactatcg acgtatgaag agtgaagagc agctcaaaga
     5641 tctaactaat gcagaacgag aagtttataa attgatagaa caaggccact cacgacgaga
     5701 tatccaaaag aaattaatga aatcagataa tactctaaaa aaccaaatta aaaatatact
     5761 gaaaaagatg tctgtttcta attccaaaga ggcaataagg aaagtgaaat caggaggttt
     5821 atggtgatta cgcgatgaag cgtaatcacc ttttttattt tgggataact tcatgtataa
     5881 agggactact ttttatagtc cctcctctaa aaaaagggtg agcatttata accccccttg
     5941 gtaaggtaga gcctcaaaaa atgacactat cttaaattgc ataaacttta taccatatag
     6001 ttaagacttg ttactcgtta taaatttaag aaaaatggtt aaatagttct tttgagtaga
     6061 atctaattta ttcataccct tcaacaaaag catgtaggca atgactagat ggtctatata
     6121 ttcaatgttc tctaaagata actgttctaa attaaggggg tggaagagat taatatcatc
     6181 agagcaaaga gaatgaaaaa aagatggact cagttagaac tagcgaaagt atcaggggtt
     6241 cctcaatgta cgatttctca acttgaaaga ggaaatcgaa aataccctac gtatgaaacg
     6301 attcgaaaaa ttgctaaagc attggatttg acattggagg aaatctacct cctacaagat
     6361 cataaagaaa aaggggtggt gaaagaggaa gagggcaaag cgcctgcctt tctatgatag
     6421 aaggaggaga ataaaatgaa gactgataaa atcaagaaat cagccactac atcaggcgga
     6481 atagaggaaa aggcttcttg ttcgctagaa gagcataaac atgttttggt cataggagaa
     6541 gtagctacag gaaaaacctc tacttatatt ttaccgaata ttcttggcga aaaagagaaa
     6601 agcttacttg tatttgatcc tcggggtaca agatatcatt ttacacaaga ggaaaagcga
     6661 gaacaggggt atattgtaaa ggattatcct gttctttcat tggataaaga aacaataaaa
     6721 catatagcac agatgctagt taaagaaaaa acagtggttt atctccattt tgatcataga
     6781 gagggggata aagagaaaga ggagacgttt actaacttga taaatacatt atatgaggca
     6841 atcgaagaac aagggttcta tcataagggt atccatgttc tgatggatga agctcaagcc
     6901 tacaaggttc ctcatctccc tttattccta gcagcaggaa gaaaatataa tgtgaatttc
     6961 tctcttacgg tgcttcactt atcttcttta cgggatttat acggcgaaga agctacacaa
     7021 cagatgataa agtatagtgt taaagggtta tttggtacga gaagtcagga agatgccgaa
     7081 tactttgctt cctttattga agggcctttt acgaaagaag aatgcaatgc acactatctc
     7141 ttttcactgc caagagaggt tcctgtatgg ctccttcctt cttctcatta acctcaaggg
     7201 acagactatt gattcaaagg ttccgaaggt gtggaaggaa tataaacaaa gtcacgtcca
     7261 tcaaatacaa aattgctgaa aaacaagtac tcattccttg aatgcttgtt tttttagcta
     7321 ttatgtccag catcagtttt ggatttaatt tagtactagt tgtgatagtt tgtatcatta
     7381 gaaaattaca tgcttcaatc tactattctc ctaaaaaaga gtaaaatgag gagttgaaga
     7441 agagtattta aagacgataa caagaacttt tttatcaaat gagaagaagg gataaaccta
     7501 tacacgaaca ggagattgca caaaatggca aacagcgtat ttatctttat catttttttt
     7561 cttctgattg tattattcca acttatgcgc tatgtttatc gtacgttact aaaacgacaa
     7621 gcattgagac gtttaatgca atcagggatt ccttacattg atcagatgga cggatttcaa
     7681 tttaagatgt atctaaaagc tttatttcag cagttaggat ataaggcgca gcttgccccc
     7741 caatcaggag atgctggagc agatctaatt atgaaaggga aaaagaagat tgtcattcaa
     7801 gctaagcgat acggcgttaa caacaaggtt agccagtcgg ctgttcaaga agtctatagc
     7861 gctcaagcct attatgaagc tgacgaagca tgggtgatga caaatagttt cttcacaaag
     7921 caagctaaag tgttggccga agtgtgtcat gtgcaattat ttgaccgtca tgctcttcaa
     7981 actttgattt tagaagtaaa tcctatacat acagccgaag atatttatcg agaggtcaag
     8041 ccagagcctc gtacatgtcc agtttgtgag aacttgttaa tcatacggca tagaaatgga
     8101 gaacgtttct ttagatgtgt ttcttttcct caatgtgagc atacagaggc gattaataaa
     8161 gaataaccta catgcagaga tcatcattaa aggtgggcaa ttcaaagcaa tgtgattaca
     8221 tatacattag ttcttcgctt agaataatat aagaggtata aaataggaag cgttttctaa
     8281 aagaaatttg gagttatata ttatacaaaa aaatgtataa actcattcgt tatcatgcag
     8341 tcttttacgt gggagaagta gagaaagttt gctacatcag aggtcgataa aatctgcata
     8401 aagaagagta aatagaaggt ccagtccctt aagcaacaag ggctggccct ttttaacttc
     8461 aagaaaaagt ttatgtgaac tgagattcta tttcgtatgc ttcctttttc tgctttctaa
     8521 atagatgaaa tgatagagtt gttatatgta ccccttacta tatctggtga aatagccttg
     8581 ttattaacaa agtatctctg tgttgaaatt cgatttagaa aggtgagatt cattttttgg
     8641 tttacttcac caccaggtcg ttttttaggt gtaatagagg aaagatacaa cgaaaggctg
     8701 cttaagatgc atggaaagaa gaaaacctac ataatggtgc acaaaatgtc ggatagctca
     8761 atttaaatcc tgctattctg atcataaagg aggtcatata aatgaatttg cttaagaata
     8821 tgaatggagc tttacaatat atcgaagaga acctaactaa cgatgtggat tttagagaag
     8881 tagcaaggcg ggctttttgt tctgaatatc actttaaaag aatgttttct ttcctagcgg
     8941 gcattacttt gtcagagtac attcgccgaa gacgccttac tcttgcagca ttcgaactta
     9001 aaaatagtaa catgaaagtg attgatgttg cgataaaata ccaatacaac tcaccagatt
     9061 ctttcacaag agcttttcaa aacttacatg gtataactcc ttcagaagct aaaaagaatg
     9121 gccattcact taaagcttat ccacgaatga ccttcgagtt atcaattaaa ggaggaaatg
     9181 aaatgaacta tcgaattgaa gaaaaagagg cattttgtat agtaggtatt aaagagagag
     9241 tccctatcat ttttcacgga gtaaatccac atattgctgc tatgtgggaa agtttaaatg
     9301 atgaaacgat aaataaactc aaaaaacttt ctaatgttaa accattagga ctgcttagcg
     9361 catctgtgaa tttttctgag ggacgaatgg aggaaaaagg ggagcttgac cattatattg
     9421 gtgtggcaac aactaaggaa tgtccagata atctgagaca acttgaagta cctgctttaa
     9481 catgggcggt attcgaagca gttgggccat tcccagatac attacaagat gtatggggac
     9541 gaatttattc tgaatggttt ccatcctcaa attatgaaca agtagaagga ccagaaattt
     9601 tatggaatga acataaagat gtaacgtcac caacttttaa aagtgagata tggatacctg
     9661 tgttaaaaaa taatgatggt agagaattgt aataaatatt tttaatagag agaaagagaa
     9721 ggttacaaat gtaatcttct cttctaattt atagatttct ataagtaaca ttaaagtact
     9781 aaacactaaa aagatttaat catctaattt tttacgatct tctgctctag gtggttcttc
     9841 catccactta tgatcaatca tacttttccc aatacgacta tatatccata aactattcag
     9901 ccctgccttt tcacagtgta ctgaaatatc ggctctcatg cttgaaatga cagaagcatt
     9961 atagtaagtt acggctactc caaaaaggaa cccagtttga agaagcatca gtttatcaga
    10021 aaaaggagaa accgtggaat ttgtaatctc tgtctccaat gtttgaggga gatgaagatt
    10081 gtctttgatt aataatgacg agaagccctc gatatgctta ttttttactt gtaggctttt
    10141 ttccaataat gtacatacag tggggtcttt agcgacttgt ttgaaagcga gcattattgc
    10201 ctttgcagtt atggctttac ttaaattaaa atagatatgt ccgctttcaa tggaattcat
    10261 aggtctacgt ttacccaaga tatttgtgac atacttgtag ttttttatga tcttaacttt
    10321 ctttggtgtt acatatgtag gtggttgttg ataaagtttt tttgagataa gaagatcttt
    10381 cgctttttta taaatctcca tcgcatcaag attacattgt tgataaaatt cgacgatatc
    10441 ttcccgtatg gaagctgtaa acgataaact atattcgtta agaccatggg tagtcattat
    10501 atgaaggtat ttgagacaca gaacgtctgt aaatagagga ggagctttta agtctacatc
    10561 ttcttctgta aatccattag gaattgggaa tttttcttgc ctaaataagt tttttaaggt
    10621 ttctatatgt tgagatgaaa tttttaaggc tgattgaaag aggtgatgta tttcaggatc
    10681 ctggattgtt tgaaccatat atttatttac acatacagat aaggtttcac ggatataatg
    10741 ggcccataaa tttgagattt cagatgatgt taagtggtta ttttcttgca atttcttttt
    10801 cctccgtata aaaactattt tttcatagtt tgccctcctt ttgagctttc atacagattc
    10861 gctttttgga taacctttct gattatcgcg gttatcgtaa ctaaaagcat atagggtata
    10921 catctaaaaa agaagaaact tcttaggggg aggaggaggg gtttttagat attcatgtga
    10981 ttagtcgatg tctcacagcg tctttgagta gtttatctag aatatgtatt cgttacacgt
    11041 ttttatgaga cgataagcat tatttgctca tgaaaaaagc accccttatt tgggcgtact
    11101 ctatctatat aataaaacat gatctaataa aagtctacaa ttttataatt ttttatatta
    11161 tagtttgatt actgaattca gtggtaccca tgggtaaata taaaattgaa aggaaattgt
    11221 ctatgacaca caagtatacc cctgttttaa tagttggagg aggcctcagc gggctcactt
    11281 ctgctctctt tttagcacgt cataacattg attatttact cattgaaaag catactagta
    11341 ccgctataca tccaaaagct ggaggaatta cgtttcgcac gatggagtta tttcgacaac
    11401 ttggattaga gtcagctatc cgtactgcta gtaaaccgtt agaacatatt cgtggaagga
    11461 ttgctgtgga aacactccaa aacatagacc tagcggagtt gaaaaaggta gagagtgtac
    11521 aaaaggcaac tgacgaaaag atagctaaaa ggattgaaaa aattagtcct tcaaaggcag
    11581 catcgtgtta tcaaacagag atagagccta tccttcttca agctattgaa caaagaaaag
    11641 ggcatatacg ctttaatact gaacttatag aataccaaca ggatgattta ggggttaccg
    11701 cgactataag ggatcgagag acaggaacag aagaaataat tcaaagtgat tatttagtcg
    11761 cggcagatgg tgctaaaagc tcaattcgta aacatacgaa cattccaacg acgggaagag
    11821 gggtaatagg cggccattat atgaatatcc attttcgagc gaatctaagt cattttctga
    11881 aaggtagtca gtttggtttc taccaaattc taaatccaga agcatttggt gcgctaatta
    11941 cagttaataa ttgtgatgaa tggatttacc atgtagccta tgatccttca aagggacagt
    12001 gcccagagga tttttctgaa gatgagtgct ataagattat aaaaaaagct ataggggttt
    12061 caaatcttga tattgttatt ttgagtattt taccttgggc agctgtggaa aagacagcta
    12121 cttgtttttg ggataagcga gtctttctag ttggagatgc ggctcatctt atgccaccta
    12181 ccggaggatt tggttcgaac acagggattc aggatgccca taacttagct tggaaattgg
    12241 cagcagtcat ccgaaaacaa gcgcatccaa gattgctcca aacttatcat gatgaaagac
    12301 atcatgttgt gaaagaaaca acgaaatatg ccagtgattt gttatttagg gctatgaata
    12361 aaggggtaag caatcttaat aatatggatc atcttgcaat tacagtagga tataaatata
    12421 gctcaggagc catcattgag gaaaaactca atacacatag aatggatcga ttagagctag
    12481 aaggacaacc aggtacacgt gctccacata tgtggttgaa gtatcaagat aagtatatat
    12541 ctaccttaga tttaataggt gaaaattttg tcctattaac gggggaagat aatagatgct
    12601 ggcgcactgc tgctgaggat gtagcttctc acctaggcat ttttattaat gtttatggca
    12661 ttggttcaga gagtgatttg gttgagtgtg agggtaattg ggaagcagta tacaatgttt
    12721 cctctcaagg tgctgtatta ataagaccag atggttttgt agcatggcgt acaaaagaga
    12781 gaatattgaa tcctaactta attcttaaac aagttatgac tacaatccta ggacaagaca
    12841 gtgaaacaat ataggtccta cacaagaaga aactgataag cctcctcaat atagattaga
    12901 aaaagcaggc agtttcctag ggatactgcc tgctttttac atcttaagtt aaaagaagcc
    12961 atcattctgt tttgaagtat tctatactta tactctcctg ctttgttcta aagcttgatt
    13021 taaatcaatt ataagagcat cactagcttc tgcaccaggc cttacaccag aatctctttg
    13081 ctgttcttca gtgacctgtt gatgttggat aacaagtgat ttgaaatctc caacattagt
    13141 taaatgtgaa acccgtttta aaaattaata catattggtt ctacatgcca cttagttcat
    13201 catagtgaag atcgacaggt gctttcttaa agaaacgcgt tgtactaatc agataaacta
    13261 tccctaacaa agtccaaatg cctcctataa ataaagaaaa aggattaaga cttatccaga
    13321 gaaaaccagt aaaaactagg ccaaggaaag ggaataggaa attctcgaaa aaagcgggtt
    13381 tctttttcct cttaaaatat gcatataaaa cacagatgtt aacaaaagtg aaagccgaga
    13441 aagctccaaa attaacgagt gctgttgcct tttctaaatc taaaaaaagc gcagttgctg
    13501 ctagtaatcc cactattaga atattaaaaa tgggtgtttt agaacgaggg tgcaaataag
    13561 agaatactct cttaggcaat gccccatctc gccccattgc atataaaaat cttgatgcta
    13621 ctaactgtga tgctaatcca gaagcaatgc aagataataa agctgcccct aaaaagaaag
    13681 caagaaacaa gttcccacct aagtgaacgg caatttcggg agaagctgct tcataattat
    13741 taaactgact agcattcgga aaaagagatt gcataagata ggtaacagta acaaaaaaga
    13801 ctagtccacc tattgctagt aagataatag cttttggaat cgttttttct ggccggattg
    13861 tttcatcaca tagatttgtg atggcatcaa agcctacaaa agataaagta aggagagctg
    13921 ctccaggaag tagagtaggg aattcattag gtgttggcaa taaatcatga ataggcatag
    13981 attgagctgg tgtagttaat aaatctttga gacacagacc tataaaaaca attacaacaa
    14041 tgaattgtag gataacaagc caagtattta gggttgtcgc tattttaatt cctatacagt
    14101 tcattaaagt aataaaagta attaatgaaa tgacccacac ccactttgga acatttggaa
    14161 accctgatga taaataaaca ctagctagta aagcattaat cataggtaag gctaaataag
    14221 cgataaagga tacccatcca accaggattg cggcataagg gtgaataatt ctctttgtat
    14281 ataaatacac agaacctgat attggatact tttgcacaag tttccgataa ctaagagctg
    14341 taaataaaat ggagataaac acaataaaat aagcaagagg gacaagccca tttgtaacat
    14401 gtgagacaat accaaaagta tcaaatacgg caaaaggagc catataagca aaaccgattg
    14461 ctactacatg tttcatcctc aattgacgct ccggagctac ttgtttagtt gaattattca
    14521 tccaaggata acctctctaa tctaaattta cccaaacact tttaacttct gtataatttt
    14581 ctaatgcata cgatcccatt tctcttccat atcctgattg tttgtaacct ccaaaaggaa
    14641 cagctgcatt cgtaagatta taacagttga cccatacggt tccggccttt aatttacttg
    14701 ctaattggtg ggcgtttttt acattttctg tccatattcc agctgctaat ccgtaaattg
    14761 agttattagc tttagaaaca acatctccta gtgtatcata agggataacg acaacaacag
    14821 gaccaaatat ctcttctttc gcaatcgtca tttcatcatc tacgtcagta aaaacagtag
    14881 gagtgataaa gcaacctttg gctaactttt ggccaccagc taatagtgtt gcgccttcat
    14941 taactccttt ctcgatgtag gaaagaacgg tatcttgttg ttttttcgat actaaggggc
    15001 ccatctccgt atcttcttct aaaccatttc ctaatttcac attttcagca taatgtttta
    15061 actcttgaac aacgaggtca taagaatctt tttgaacata gactctagac ccggcacaac
    15121 aaacttgccc ttggttagcc ataattccag aaaatacacc aggtatagct tttgttaagt
    15181 ctgcatcagg taagataatg ttaggagact ttcctcctaa ttctaatgtt acgcgcttta
    15241 gtgtttgtgc ggccttctgc ataattgctt tcccgacggc ggtagagcct gtaaaagcaa
    15301 tcttatcgac atcagggtgc tgtacaagtg cttcacctgt gatagaaccc ttcccattta
    15361 taatgtttac aactcccttt ggaaaaccag cttcttcaat taacttagca agatataaag
    15421 ctgaaagggg agtttgctct gcaggcttca atacgaccgt acatccagta gctaaagcag
    15481 gtgcaatctt ccaaatagcc atcataatag gaaagttcca agggataatt tgtcctacaa
    15541 cgccgactgg ttcatgctgt gtataagtga aatattgagg agatatagga atcgtttgtc
    15601 caccccattt tgttgtccat cctgcataat aacgaagctg ctcaatagcg tttggtaagt
    15661 cattacctag catttctgcg ataggtttcc cattatctaa tgtatcaatt tctgctaaaa
    15721 tgcgaatatc tctttccatt aagtttgcta acttatataa atattgacca cgaattgaac
    15781 catccatccg agcccattct ccgtgttcga atgcagatcg agctgcataa acagctcgat
    15841 ctacatcttc ttttgttgcc tcagcaaccc gagcgagaag ttctccggta gctggattaa
    15901 atgtttcaaa agtaccagtc ataggggagg aataccattc cccattaata aaaagtgttt
    15961 taggttcttc taagaaatct aatacttctt ttgttatgtt caacacgagt gtttcctcct
    16021 tatagaccaa gtcgttttga ataagcagag agtgattcat ctacaattga gataattgtc
    16081 tcgatatcct cttgttgtga gataagaggg ggagcaatag ctacaatgtt catcccaggt
    16141 tcgaaatcaa atcctctaat aagcaatcca cgttttttac attcttccac aatactcatt
    16201 gcggcagctt cctctggtgt aaaggtgatg ttttgctcag gatctttcat taaatcaaat
    16261 cctgttaaca accctcgtcc tcgaccatta tgaaagaagt gatatttatc actgagataa
    16321 tcaaatcctt ttaaaagaag tttccccatt tgatcagctt gatcaataag attttccctt
    16381 tcaataattt caagattttt taagccaact gcgcatgctg tagggtgacc actataggta
    16441 aatccgtgag caagcatatc tggtacttca catatagcat ccataatagg ggtgcgcatt
    16501 acaaccgctc caagttgagc atatccactt gtaattcctt ttgctacaga catgaagtca
    16561 ggaacaatgt cccaatgatt tacaccgaag gaacgaccag tacgaccaaa tccacaaatt
    16621 acttcatcag caataaggag aatattttgc tcatcacaca gtttacggac agcctgtaaa
    16681 taatcttctg gagggacgtg gacgccacca gcgccttgaa taggttctat aataacagct
    16741 gctacatgat tagcgccttc tcgctcaata gtgccacgaa tactattttg ataagaagga
    16801 tgattaatat caccaagttc acaagaagtt aaatggggtt ctgcatttat gatgtcggga
    16861 tctcccgagc ctgaaaatgc acgatatact tcaatacctg tagctctttg agcagcaact
    16921 gttacaccat gatagcctct ttttaatgaa ataattttct ttttgtttgc taatcctttt
    16981 ctttcccaat aaaaacgagc caatttaaaa gctgtatcat tagattcaga acccccggag
    17041 gtgtaaaata cgctgtctaa gtcacctggt gtcatcgaag taattttctc ggcaagtttc
    17101 acggccggtt catttgaata tccataaaac attgagctgt aagctagctt ttgcatttga
    17161 tcgaagctaa ctagtgctaa ctctttatta ccgtgtccta cgtttacatt ccatagcata
    17221 gatacaccat caatatattt gttgttatcc atatcaaaga tatgaagtcc ttcacctcgc
    17281 tcaaaaataa tcgcaggtcc attatttcga ttaaaggcag gggacgtaga aggatgtaaa
    17341 atatgttgtt tatctaattc agctagtgta taaagagttt gatttttcat tgatatcgct
    17401 cctattcatt aaatagtttt tgggattttt gccccagata actgacacac aacatctagc
    17461 aaaagattag cgccatttac taagtcgtca tctctcgtaa attcctcttc attgtgacta
    17521 atgccgcgat ggcttggaac aaatatcatc cctgttttag ctatttcagc catatacttg
    17581 gcatcatgtc cagggccgct aaacattctt ttagtagata aatttctctt ctctgcacat
    17641 ttgctaattg tttcaatcac tttttcagaa aaagtaacgc tatcattttc ccatgaggta
    17701 tgaaaagtga gttctacatt gcataaacct gagattgtac tcaattgctg tttcattact
    17761 tcaagagctc tttctctctg ttcatcttct tcatggcgaa tatcaacaat aaattcaact
    17821 tttcctgaaa taacattagg tacgttagga tagacattta attgtccaac tgtagttttt
    17881 aaaccttcat attcctgtgc taatttatct atgctttcta tcatctttgc tgctgctaca
    17941 actgcatctt tacggttttc cattggtgtt ggaccagcgt gattcatctc accttccact
    18001 gtaatactaa tccaactaat tccttggatt ccttcgacaa ctccaatttc taattgttct
    18061 tcttcaagaa taggaccttg ttcaatatgt agttctataa agtattccgc tttttgtaac
    18121 ctattctctt ttagtccttt ataaccaata cctgaaagtg catcatgaaa ctttattccg
    18181 tctttatctt ggcgagaata aatgaaatct ttctcaaata caccacatac tccaccagat
    18241 cctagcattg gtggttcaaa tcttgctcct tcttcattcg taaaattaat aatctcaatt
    18301 ggatgatctg tttgtacatt tgcctcgttc agagaacgaa caacctccaa agctgctaat
    18361 acacctaaaa tcccatcaaa acgccctcca caaggctgag tatcgagatg tgatccaatg
    18421 acaataggca tttgatgatg agattttccc tcacgtctac catacatatt gccaaaatca
    18481 tctactctaa tagataatcc ttcttcttca aaccaattga ttagtagatt cctcatttgc
    18541 ttatcgtcta ttgataaagc taaacgatgt aggcctccat taggagttgc tccaattgct
    18601 gaactttctt ttatagactg gagcatcctt tgttgattaa tatttaaacc attcatattt
    18661 gttaaatcac ctccgtactg taattagttg caagtatcgt gccaacataa aaagttaagg
    18721 attaattgaa attttcagaa taatacttta aaatgaatcg atactgattc aaatacaaat
    18781 cgatatcgac tcagatggga ttggagggaa agctatgagc cctacctttt taagctcaga
    18841 aataaaaatg atgcttgatc aattaaaaga tggtatttat atagctaaca aaaatggagt
    18901 aacattatgg attaatcaaa caagtgaaaa acaactaggt gtgaagcgaa aagatattat
    18961 tggaaaaaca gctgatgaac tagaagcacg aaatttattt actccttccg taacaaaaat
    19021 tgtcctaaag aaaagaaaaa caatatcgaa agctcaaact tcaaaaggaa ttcaatattt
    19081 agctacaggt agtttaattg aattagagga aacaggagaa gaatacgtaa ttgtgcatgt
    19141 taaagatatt tctgagatgg ttaaaaatgc ttttaaactt aaaaaagcag aaactcttat
    19201 gagtcaatac tggaatgaac tacagaaaat gaaaagtgag aaaagagaca gaacaggaga
    19261 aaagagactt attggaacaa gtgacgctca taatgaagta atggatcttt taagaagagt
    19321 cgctaatttt gacgctacta ttctattaca aggagaaaca ggagtcggaa aaagcgtgtt
    19381 cgcaaaagaa gtccatgttc taagtgaccg aagaaatcaa ccatttgttc aagtaaactg
    19441 cggagctctt ccagctaatt taattgagtc agaattgttt ggttataaga aaggagcttt
    19501 tacaggggct aacagcagag gaaaaacagg tttaatagaa gaagcatctg gtggaacctt
    19561 atttttagat gaaattggtg aattccccct agaactacag cctaaactgc ttcaatttct
    19621 tcaagacaag tcgtttcttc ctattggttc tacagtttta cagcactctg atacaaggat
    19681 aattacagca acaaaccaag atttactaca gcttgtaaaa gaaaaacgtt ttagagaaga
    19741 tctgtattat cggttaaatg tcattcctat agagattctt tcccttaaag aacgaagaga
    19801 agacattctc ccacttgcgc atcactttct tcaaacttat aactataaat atcaaagaaa
    19861 tgtcgtacta tcaaaagaag ttcaaccttt tttctatcgt tataactggc ccggaaatat
    19921 ccgtgaacta gaaaatctta ttgaaagact tgttattaca gtaaggcaag aaaaaatctt
    19981 agaaaatgac ttgccatacc acatgctaaa aactaacgat gaaccagctt cattaggagc
    20041 agaagaagag gagttacaag gaaaaagcct ttctgagtat ttagatagta tagagcgtaa
    20101 gatgatttta aaagcttatt ctaaatataa atctactcgt aaaatggcag aaaagcttgg
    20161 cttgactcag tccgctgttg tacgtcgaat gaaaaaatat gatatttcat aactttttat
    20221 ttactaatct ctaaatatta aattgaaaat taattggcac aaaacttgca ttataaataa
    20281 ctgtcagaaa ctgaaaggtt taaggaggaa tttacagtga gtttatcaat tacaaatagt
    20341 acacctaaaa aggacgggtt tagaatgcct ggagagtttg aacaacatgc aggtacatgg
    20401 atgttatggc ctgtcagaac agacacttgg cgcaatggag caaaacctgc acaacaagtt
    20461 ttcgctaaag tagtaagtac tatctctgag tttgaacctg ttactgtagg tgtgaacgcg
    20521 gaacagtacg aaaatgcaag agctatgctt cctcatcatg ttcgagttgt agaaatctcc
    20581 tcaaatgatg cttggatgag agatattggt cctacatttg taaagaatga ggagggagtg
    20641 ataagaggaa taaactgggg atttaatgct tggggagggc ttcaaggagg attatacttt
    20701 ccatgggatc ttgatttaat ggtgaaaaag aaagttcttg aaatcgaaaa taaagactgg
    20761 tatgaatgta cagaatttat cttagaaggt ggatctatta ctgtagacgg agaaggaact
    20821 ttaattacaa cagagcaatg tctattaaac aaaaatcgca acccacatct ttctaaaagt
    20881 gaaattgaag ataaattaaa agagtattta aacattgaaa aagtaatatg gcttaaagat
    20941 ggactgatag gagatgaaac agatggacat gtagatgact tggctttttt tgttcgtcca
    21001 ggagaagttg ctatcggctg gacagaagat gttaatcatc ctcaatacca tgttcatcag
    21061 gaagcatata aaatactaaa agaagctaca gatgcaaagg gcagatctct aaccattcat
    21121 aaaattgaat tacctaatga actcattctc tcaaaagaag caagtgagaa tatcgatttt
    21181 gcatcatcta gttataaacg tgaagaaggc atgccttttg ttgccacata tattaattgc
    21241 tatctatgca acggagctgt aattgttcct tcatttgatg atccaagtga tgataaagct
    21301 cgaaagaaat ttgaagacat ctatccagat cgaaaagtca tcttaataga tactcgtgag
    21361 ctgccaatag ctggaggaaa tattcattgt attacacaac aacaacctgc atctacgtct
    21421 cagaaaaatt attaaatagt tcttttaaat gaaaattgga gtaaaagtta atttatcatc
    21481 ttgtctatgt aaggcaagat gacaaatttc aacataaaat atacctatat gctattctta
    21541 ggttggaaaa tagaaaaaca accagctgta tgtctcttta aatgccttac aatagtattt
    21601 cttaattaaa tac
//
