Select genomic region:
Overview
8.1
26.1
28.1
40.1
40.2
40.3
45.1
48.1
48.2
52.1
55.1
59.1
59.2
59.3
62.1
65.1
67.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LWAI01000002.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | terpene-precursor | 378,845 | 399,723 |  |

NZ_LWAI01000023.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 26.1 | terpene | 120,734 | 142,590 |

NZ_LWAI01000025.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 28.1 | azole-containing-RiPP | 22,125 | 45,670 |

NZ_LWAI01000037.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 40.1 | lassopeptide | 59,353 | 83,206 | Medium | paeninodin | ribosomal:unmodified
Region 40.2 | NRP-metallophore,NRPS | 102,327 | 153,961 | High | bacillibactin/bacillibactin E/bacillibactin F | NRPS:Type I
Region 40.3 | opine-like-metallophore | 472,859 | 495,006 | High | bacillopaline | other:other

NZ_LWAI01000043.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 45.1 | NRPS | 1 | 3,741 |

NZ_LWAI01000046.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 48.1 | NRPS-like | 1 | 21,613 | Low | WLIP | NRPS:Type I
Region 48.2 | NRPS,betalactone | 43,497 | 103,820 | Low | fengycin | NRPS:Type I

NZ_LWAI01000050.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 52.1 | NRPS | 1 | 11,462 | Low | nostopeptolide A2 | NRPS:Type I+PKS

NZ_LWAI01000053.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 55.1 | NRPS | 1 | 27,201 |

NZ_LWAI01000057.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 59.1 | lanthipeptide-class-ii | 179,140 | 207,661 |
Region 59.2 | terpene | 235,813 | 256,631 |
Region 59.3 | T3PKS | 494,556 | 535,644 |

NZ_LWAI01000060.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 62.1 | T1PKS,NRPS | 1 | 75,328 | Low | zwittermicin A | NRPS:Type I+PKS

NZ_LWAI01000064.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 65.1 | NI-siderophore | 13,877 | 35,818 | Medium | schizokinen | NRPS:Type IV

NZ_LWAI01000066.1 (Priestia endophytica)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 67.1 | RRE-containing | 9,989 | 27,692 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | terpene-precursor | 378,845 | 399,723 |  |
Region 26.1 | terpene | 120,734 | 142,590 |
Region 28.1 | azole-containing-RiPP | 22,125 | 45,670 |
Region 40.1 | lassopeptide | 59,353 | 83,206 | Medium | paeninodin | ribosomal:unmodified
Region 40.2 | NRP-metallophore,NRPS | 102,327 | 153,961 | High | bacillibactin/bacillibactin E/bacillibactin F | NRPS:Type I
Region 40.3 | opine-like-metallophore | 472,859 | 495,006 | High | bacillopaline | other:other
Region 45.1 | NRPS | 1 | 3,741 |
Region 48.1 | NRPS-like | 1 | 21,613 | Low | WLIP | NRPS:Type I
Region 48.2 | NRPS,betalactone | 43,497 | 103,820 | Low | fengycin | NRPS:Type I
Region 52.1 | NRPS | 1 | 11,462 | Low | nostopeptolide A2 | NRPS:Type I+PKS
Region 55.1 | NRPS | 1 | 27,201 |
Region 59.1 | lanthipeptide-class-ii | 179,140 | 207,661 |
Region 59.2 | terpene | 235,813 | 256,631 |
Region 59.3 | T3PKS | 494,556 | 535,644 |
Region 62.1 | T1PKS,NRPS | 1 | 75,328 | Low | zwittermicin A | NRPS:Type I+PKS
Region 65.1 | NI-siderophore | 13,877 | 35,818 | Medium | schizokinen | NRPS:Type IV
Region 67.1 | RRE-containing | 9,989 | 27,692 |

No secondary metabolite regions were found in these records:
  NZ_LWAI01000014.1 (Priestia endophytica)
  NZ_LWAI01000063.1 (Priestia endophytica)
  NZ_LWAI01000067.1 (Priestia endophytica)
  NZ_LWAI01000020.1 (Priestia endophytica)
  NZ_CM009980.1 (Priestia endophytica)
  NZ_CM009981.1 (Priestia endophytica)
  NZ_LWAI01000001.1 (Priestia endophytica)
  NZ_LWAI01000003.1 (Priestia endophytica)
  NZ_LWAI01000004.1 (Priestia endophytica)
  NZ_LWAI01000005.1 (Priestia endophytica)
  NZ_LWAI01000006.1 (Priestia endophytica)
  NZ_LWAI01000008.1 (Priestia endophytica)
  NZ_LWAI01000009.1 (Priestia endophytica)
  NZ_LWAI01000010.1 (Priestia endophytica)
  NZ_LWAI01000011.1 (Priestia endophytica)
  NZ_LWAI01000012.1 (Priestia endophytica)
  NZ_LWAI01000013.1 (Priestia endophytica)
  NZ_LWAI01000015.1 (Priestia endophytica)
  NZ_LWAI01000016.1 (Priestia endophytica)
  NZ_LWAI01000017.1 (Priestia endophytica)
  NZ_LWAI01000018.1 (Priestia endophytica)
  NZ_LWAI01000019.1 (Priestia endophytica)
  NZ_LWAI01000021.1 (Priestia endophytica)
  NZ_LWAI01000022.1 (Priestia endophytica)
  NZ_LWAI01000024.1 (Priestia endophytica)
  NZ_LWAI01000026.1 (Priestia endophytica)
  NZ_LWAI01000027.1 (Priestia endophytica)
  NZ_LWAI01000028.1 (Priestia endophytica)
  NZ_LWAI01000029.1 (Priestia endophytica)
  NZ_LWAI01000030.1 (Priestia endophytica)
  NZ_LWAI01000031.1 (Priestia endophytica)
  NZ_LWAI01000032.1 (Priestia endophytica)
  NZ_LWAI01000033.1 (Priestia endophytica)
  NZ_LWAI01000034.1 (Priestia endophytica)
  NZ_LWAI01000035.1 (Priestia endophytica)
  NZ_LWAI01000036.1 (Priestia endophytica)
  NZ_LWAI01000038.1 (Priestia endophytica)
  NZ_LWAI01000039.1 (Priestia endophytica)
  NZ_LWAI01000041.1 (Priestia endophytica)
  NZ_LWAI01000042.1 (Priestia endophytica)
  NZ_LWAI01000044.1 (Priestia endophytica)
  NZ_LWAI01000045.1 (Priestia endophytica)
  NZ_LWAI01000047.1 (Priestia endophytica)
  NZ_LWAI01000048.1 (Priestia endophytica)
  NZ_LWAI01000049.1 (Priestia endophytica)
  NZ_LWAI01000051.1 (Priestia endophytica)
  NZ_LWAI01000052.1 (Priestia endophytica)
  NZ_LWAI01000054.1 (Priestia endophytica)
  NZ_LWAI01000055.1 (Priestia endophytica)
  NZ_LWAI01000056.1 (Priestia endophytica)
  NZ_LWAI01000058.1 (Priestia endophytica)
  NZ_LWAI01000059.1 (Priestia endophytica)
  NZ_LWAI01000061.1 (Priestia endophytica)
  NZ_LWAI01000062.1 (Priestia endophytica)
  NZ_LWAI01000065.1 (Priestia endophytica)

Compact view
NZ_LWAI01000002.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 378,845 - 399,723 nt. (total: 20,879 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
A4U60_RS02530: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
A4U60_RS02495: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

A4U60_RS02500: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000665.5 |  | 0.39 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000668.5 |  | 0.38 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000665.5 |  | 0.39 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000668.5 |  | 0.38 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
A4U60_RS02500: PT_FPPS_like
Domain 1 (32 - 291): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.77 out of 20.97
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.73 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.90 out of 26.06
Confidence: medium
Additional weak hits (3):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.70 out of 33.73
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.47 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_LWAI01000023.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 120,734 - 142,590 nt. (total: 21,857 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: peptidase
A4U60_RS10420: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000670.4 |  | 0.34 | terpene | thalianol, thaliandiol, thalianin | Arabidopsis thaliana
BGC0001314.3 |  | 0.33 | terpene | tirucalla | Arabidopsis thaliana
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000249.5 |  | 0.28 | PKS | nogalamycin | Streptomyces nogalater
BGC0001736.3 |  | 0.27 | NRPS | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001737.3 |  | 0.24 | NRPS, PKS | phenalamide | Corallococcus coralloides
BGC0001394.5 |  | 0.24 | NRPS, PKS | phenalamide A2 | Myxococcus stipitatus DSM 14675
BGC0001567.4 |  | 0.24 | NRPS | cysteoamide | Streptomyces lincolnensis
BGC0001771.4 |  | 0.22 | NRPS | scleric acid | Streptomyces sclerotialus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000670.4 |  | 0.34 | terpene | thalianol, thaliandiol, thalianin | Arabidopsis thaliana
BGC0001314.3 |  | 0.33 | terpene | tirucalla | Arabidopsis thaliana
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000249.5 |  | 0.28 | PKS | nogalamycin | Streptomyces nogalater
BGC0001736.3 |  | 0.27 | NRPS | pepteridine A, pepteridine B | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001737.3 |  | 0.24 | NRPS, PKS | phenalamide | Corallococcus coralloides
BGC0001394.5 |  | 0.24 | NRPS, PKS | phenalamide A2 | Myxococcus stipitatus DSM 14675
BGC0001567.4 |  | 0.24 | NRPS | cysteoamide | Streptomyces lincolnensis
BGC0001771.4 |  | 0.22 | NRPS | scleric acid | Streptomyces sclerotialus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
A4U60_RS10405: T2TS
Domain 1 (4 - 617): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.38 out of 23.79
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
Additional weak hits (2):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.64 out of 29.38
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.45 out of 31.73
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CRP | Cyclic AMP receptor protein
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes

NZ_LWAI01000025.1 - Region 1 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 22,125 - 45,670 nt. (total: 23,546 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
A4U60_RS11365: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

A4U60_RS11380: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: kinase
A4U60_RS11370: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001928.2 |  | 0.47 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002496.3 |  | 0.45 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000569.5 |  | 0.43 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0001173.5 |  | 0.43 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000607.5 |  | 0.42 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001928.2 |  | 0.47 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002496.3 |  | 0.45 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000569.5 |  | 0.43 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0001173.5 |  | 0.43 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000607.5 |  | 0.42 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.80 out of 32.93
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.16 out of 26.06
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.87 out of 29.72
Confidence: medium
Additional weak hits (5):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.31 out of 30.97
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.56 out of 32.74
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.53 out of 29.25
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.33 out of 30.22
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (22124...45670)
A4U60_RS11415
  RRE type: Heterocycloanthracin_C_RRE
  Location: 0 - 99
  Score: 166.0
  RRE type: Thiopeptide_F_RRE
  Location: 7 - 89
  Score: 50.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
NtrC | Nitrogen regulatory protein C

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_LWAI01000037.1 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 59,353 - 83,206 nt. (total: 23,854 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
A4U60_RS15005: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.70 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.3 |  | 0.53 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000571.3 |  | 0.50 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001779.5 |  | 0.46 | ribosomal | siamycin | Streptomyces nodosus
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.42 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.41 | ribosomal | geobacillin II | Geobacillus thermodenitrificans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.70 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.3 |  | 0.53 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000571.3 |  | 0.50 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001779.5 |  | 0.46 | ribosomal | siamycin | Streptomyces nodosus
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.42 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.41 | ribosomal | geobacillin II | Geobacillus thermodenitrificans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.98 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.54 out of 20.97
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.09 out of 24.78
Confidence: medium
Additional weak hits (2):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.67 out of 29.51
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (59352...83206)
A4U60_RS15020
  RRE type: Stand_Alone_Lasso_RRE
  Location: 9 - 92
  Score: 91.9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_LWAI01000037.1 - Region 2 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 102,327 - 153,961 nt. (total: 51,635 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
A4U60_RS15330: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase acetyltransferase aminotransferase
A4U60_RS15280: acetyl-CoA acetyltransferase

smcogs
  SMCOG1124: acetyl-CoA acetyltransferase

A4U60_RS15365: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

A4U60_RS15380: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase
A4U60_RS15345: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase mutase
A4U60_RS15335: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

A4U60_RS15395: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: ligase synthase
A4U60_RS15285: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

A4U60_RS15340: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

A4U60_RS15350: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

A4U60_RS15420: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001185.5 |  |  | 1.02 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  | 0.86 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000343.5 |  |  | 0.85 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0000401.5 |  |  | 0.83 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002695.2 |  |  | 0.80 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001132.4 |  |  | 0.76 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.5 |  | 0.79 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.74 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0000401.5 |  | 0.73 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002695.2 |  | 0.72 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.54 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.77 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.36 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.76 out of 29.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.28 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
Additional weak hits (9):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.94 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.74 out of 30.11
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.61 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.50 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.38 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.62 out of 29.38
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.33 out of 29.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.30 out of 30.25
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 102326 - 153961:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
A4U60_RS15285: X
AMP-binding (7..381): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    SCNGHSLFLYGSYSLSSGAYEFYGASELSFVSVL
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

A4U60_RS15340: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (30..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SKSLYPLSSPGGGVQVGGAQQVYGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (88% 8Å match)
  Stachelhaus code match:
    90% (moderate)

A4U60_RS15350: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (461..858): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMTFDISALELQALVGGETNFYGPTETTIWSSS
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (91% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (1509..1920): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEINMYGITETTVHVSF
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_LWAI01000037.1 - Region 3 - opine-like-metallophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 472,859 - 495,006 nt. (total: 22,148 nt) Show pHMM detection rules used
opine-like-metallophore: (CntL and CntM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | opine-like-metallophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002488.3 |  | 0.83 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002487.3 |  | 0.79 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002489.2 |  | 0.52 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.50 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002322.3 |  | 0.41 | ribosomal | citrocin | Citrobacter pasteurii
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000519.4 |  | 0.40 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.39 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002488.3 |  | 0.83 | other (other) | bacillopaline | Paenibacillus mucilaginosus KNP414
BGC0002487.3 |  | 0.79 | other (other) | staphylopine | Staphylococcus aureus subsp. aureus Mu50
BGC0002489.2 |  | 0.52 | other (other) | pseudopaline | Pseudomonas aeruginosa PAO1
BGC0002490.2 |  | 0.50 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002322.3 |  | 0.41 | ribosomal | citrocin | Citrobacter pasteurii
BGC0000551.5 |  | 0.41 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000519.4 |  | 0.40 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.39 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 22.43 out of 23.79
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.26 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.48 out of 26.85
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.93 out of 27.55
Confidence: medium
Additional weak hits (4):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.84 out of 29.38
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.34 out of 39.62
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.86 out of 29.38
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
RutR | Regulator of the pyrimidine and purine metabolism

NZ_LWAI01000043.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 3,741 nt. (total: 3,741 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
A4U60_RS18055: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.62 | NRPS | AM-toxin | Alternaria alternata
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001240.4 |  | 0.62 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001825.4 |  | 0.62 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.4 |  | 0.62 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.60 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001844.4 |  | 0.57 | NRPS | holrhizin A, holrhizin B, holrhizin C, holrhizin D | Paraburkholderia rhizoxinica HKI 454
BGC0001873.3 |  | 0.56 | NRPS | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.62 | NRPS | AM-toxin | Alternaria alternata
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001240.4 |  | 0.62 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001825.4 |  | 0.62 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001758.4 |  | 0.62 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.60 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001844.4 |  | 0.57 | NRPS | holrhizin A, holrhizin B, holrhizin C, holrhizin D | Paraburkholderia rhizoxinica HKI 454
BGC0001873.3 |  | 0.56 | NRPS | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NZ_LWAI01000046.1 - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 21,613 nt. (total: 21,613 nt) Show pHMM detection rules used
Region on contig edge.
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
A4U60_RS18170: monooxygenase FAD-binding

smcogs
  SMCOG1050: monooxygenase FAD-binding

A4U60_RS18180: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase
A4U60_RS18185: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: deacetylase hydrolase
A4U60_RS18130: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

A4U60_RS18190: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Ligases: ligase
A4U60_RS18120: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease
A4U60_RS18175: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.64 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.63 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.63 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001641.4 |  | 0.63 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.63 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002135.2 |  | 0.62 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002277.2 |  | 0.62 | NRPS | atromentin | Suillus grevillei
BGC0001135.5 |  | 0.62 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.64 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.63 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.63 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001641.4 |  | 0.63 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.63 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002135.2 |  | 0.62 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002277.2 |  | 0.62 | NRPS | atromentin | Suillus grevillei
BGC0001135.5 |  | 0.62 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.10 out of 26.85
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.53 out of 27.78
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46
Confidence: strong
Additional weak hits (2):
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.64 out of 29.72
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.73 out of 30.98
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN | Regulator of nitrogen assimilation and virulence
RutR | Regulator of the pyrimidine and purine metabolism

NZ_LWAI01000046.1 - Region 2 - NRPS,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 43,497 - 103,820 nt. (total: 60,324 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
A4U60_RS18460: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

A4U60_RS18510: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase
A4U60_RS18390: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

A4U60_RS18520: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

A4U60_RS18540: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: decarboxylase hydratase
A4U60_RS18435: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

A4U60_RS18535: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
A4U60_RS18430: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

A4U60_RS18495: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

A4U60_RS18515: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

A4U60_RS18530: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002284.3 |  |  | 0.36 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000706.3 |  |  | 0.34 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000131.5 |  |  | 0.33 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0001261.3 |  |  | 0.33 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  |  | 0.32 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  |  | 0.30 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  |  | 0.30 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.30 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  |  | 0.30 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002412.2 |  |  | 0.29 | NRPS | holomycin | Photobacterium galatheae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.61 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.61 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 26.06 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.96 out of 29.25
Confidence: medium
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 30.39 out of 36.54
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.87 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.10 out of 21.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.40 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19
Confidence: medium
Additional weak hits (8):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.74 out of 30.22
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.93 out of 27.55
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.89 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.05 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.84 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.97 out of 36.54
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.81 out of 35.63
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.31 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 43496 - 103820:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 43496 - 90507:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
A4U60_RS18430: X - Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (266..656): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FIMAFDISLLEVESLLAGELNIYGPTETTICAAV
  Nearest Stachelhaus code(s):
    Ala DILICALICK (44% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1303..1683): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNTLLSGDISLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

A4U60_RS18515: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (93..526): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VNYAWTMHIWGGFTSLVGENNTWGQTETAGSPIA
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
HgtR | Hydrogen-dependent regulator
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_LWAI01000050.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 11,462 nt. (total: 11,462 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
A4U60_RS19470: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

A4U60_RS19475: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.71 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001135.5 |  | 0.71 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.71 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.71 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001135.5 |  | 0.71 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.71 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 11462:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ala) + (Ser - Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
A4U60_RS19470: Ser - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (496..901): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFTSGESNLYGPTEATVDVTY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1558..1945): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
  Nearest Stachelhaus code(s):
    Pro DVQFIAQVVK (56% 8Å match)
  Stachelhaus code match:
    80% (moderate)

A4U60_RS19475: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (553..945): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
  Nearest Stachelhaus code(s):
    Ala DLFNNALTYK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_LWAI01000053.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 27,201 nt. (total: 27,201 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
A4U60_RS20405: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

A4U60_RS20415: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Hydrolases: dehalogenase
A4U60_RS20380: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

Ligases: ligase
A4U60_RS20345: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

A4U60_RS20350: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.5 |  | 0.68 | NRPS | sevadicin | Paenibacillus larvae
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.65 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.65 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.65 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.64 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000426.5 |  | 0.68 | NRPS | sevadicin | Paenibacillus larvae
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.65 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.65 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.65 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.64 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.36 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.86 out of 23.79
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.19 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.00 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.92 out of 28.19
Confidence: medium
Additional weak hits (4):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.42 out of 29.25
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.44 out of 20.01
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.49 out of 20.01
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 27201:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
A4U60_RS20345: X
AMP-binding (466..870): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
  Nearest Stachelhaus code(s):
    Glu DVWHFGRINK (71% 8Å match)
    Gln DAWQFGLIDK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

A4U60_RS20350: Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (457..866): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_LWAI01000057.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 179,140 - 207,661 nt. (total: 28,522 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
A4U60_RS22265: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
A4U60_RS22245: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

A4U60_RS22260: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase
A4U60_RS22275: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000516.4 |  | 0.58 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.58 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.56 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000552.3 |  | 0.55 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001407.5 |  | 0.54 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000497.3 |  | 0.53 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0001391.3 |  | 0.53 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000516.4 |  | 0.58 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.58 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.56 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000552.3 |  | 0.55 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001407.5 |  | 0.54 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000525.5 |  | 0.54 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000497.3 |  | 0.53 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0001391.3 |  | 0.53 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for A4U60_RS22245

A4U60_RS22240
Leader:
MEERLYGFAGKLEEELEEIALKEISGG
Core:
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
Core with dehydrations:
A E Q R G I Dha Q G N D G H Q Cys Dhb I Dhb W E Cys Dha I Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for A4U60_RS22240

100.0%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
84.4%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S Q G N D G C T I T W E C S I C P T H T C W C
2
A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
83.9%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A+ +G I S Q G N D G C T I T W E C S I C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
with 104 more sequence matches
Only the first 10 are displayed here.
81.2%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C-W C
31
A E Q R G I S Q G N D G C T+T W E C S+C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
81.2%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S Q G N D G C T+T W E C S I C P T H T C W C
2
A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
78.8%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E R G I S Q G N D G C T I T W E C +C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
75.0%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S+ N D G C T+T W E C S I C P T H T C W C
2
A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
72.7%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
E R G+S Q G N D G C T I T W E C +C P T H T C W C
3
V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
71.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E +G+S Q G N D G C T+T W E C +C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
68.4%
NC_023073.1 and 73 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
65.8%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G C T+T W E C +C P T H T C+C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
65.6%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15515_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W
30
E + I S+G N D G C T+T W E C S I C P T T C W
1
V E T K K I S K G N D G K W C T L T W E C S I C P T K T C W
30
50.0%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
4
R G I S Q G N D G H Q C T I T W E C S I C P T H T C W
30
R +S+G N G C T+T W E C I C P+H T C+
7
R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for A4U60_RS22240

25.8%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
9
G N D G H Q C T I T W E C
21
G N G C T+T E C
11
G N K G A Y C T L T V E C
23
25.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
9
G N D G H Q C T I T W E C
21
G N+G C T+T E C
13
G N N G G W C T L T K E C
25
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
C T I T W E C
21
C T++ E C
28
C T L S K E C
34
A4U60_RS22255
Leader:
MKKNMKAIEEVSEQELKELAGG
Core:
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
Core with dehydrations:
A E E R A I W Dhb V Dhb I P I Dha L A A Cys P Dhb Dhb Q Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for A4U60_RS22255

100.0%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
81.2%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R W T+ I P I S L A A C P T T+C A S I V S P C N
1
A E E R--W T I I I P I S L A A C P T T R C A S I V S P C N G
30
78.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N
31
A+E R W T+ I P I S L A A C P T T+C A S I V S P C N
1
A D E R--W T I I I P I S L A A C P T T R C A S I V S P C N
29
with 69 more sequence matches
Only the first 10 are displayed here.
78.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R W T+ I P I S L A A C P T T+C A S I V S C N
1
A E E R--W T I I I P I S L A A C P T T R C A S I V S S C N G
30
67.6%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E + T V T I P I S A C P T T Q C A S I V P C N+
2
A E P Q G T P T V T I P I S A A I C P T T Q C A S I V R P C N N
33
65.6%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E E R A I W T V T I P I S L A A C P T T
1
A E E R A I W T V T I P I S L A A C P T T
21
64.7%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
2
E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N
31
+ A W T+T I P I S A A C P T T Q C A S+V P C N
4
N Q P A T W T I T I P I S A A A C P T T Q C A S V V K P C N
33
60.0%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S L A C P T T+C A S I V S P C
11
T V T I P I S L A G C P T T K C A S I V S P C K G
35
54.5%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
+E + I P+S L A C P T T+C A S+V P C N D
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N D
33
53.1%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide
Lanthipeptides: FE328_RS09035_lanthipeptide
7
W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
W T +P I S L A C P+T+C A S I P C N
3
W T S L V P I S L A I C P S T K C A S I T R P C N K
28
51.5%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
+E + I P+S L A C P T T+C A S+V P C N
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N G
33
50.0%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S C P T T+C A S+V P C N D
14
T V T I P I S A W G C P T T K C A S V V E P C N D
38
50.0%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S C P T T+C A S+V P C N D
14
T V T I P I S A W G C P T T K C A S V V K P C N D
38

#### MIBiG 4.0 matches for A4U60_RS22255

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
V T I P I S L A A C P T T Q C A S
25
V + +S A C P T T+C S
19
V A V G V S A A F C P T T K C T S
35
18.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
C P T T Q C A S
25
C P T T+C S
17
C P T T K C T S
24
allorf_188622_188780
Leader:
MGFNSISFTINFYIFILIQIFSKFSERFHSENRILFA
Core:
V F T M I D C N N L H T S V R
Core with dehydrations:
V F Dhb M I D Cys N N L H Dhb Dha V R

#### antiSMASH-DB 4.0 matches for allorf_188622_188780

100.0%
NZ_LWAI01000057.1 and 1 other:
NZ_LWAI01000057.1 Lanthipeptides: allorf_188622_188780_lanthipeptide
Lanthipeptides: allorf_188622_188780_lanthipeptide
1
V F T M I D C N N L H T S V R
15
V F T M I D C N N L H T S V R
1
V F T M I D C N N L H T S V R
15
93.3%
NZ_FOXX01000007.1 and 2 others:
NZ_LWAG01000015.1 Lanthipeptides: allorf_021729_021887_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021729_021887_lanthipeptide
Lanthipeptides: allorf_282028_282186_lanthipeptide
1
V F T M I D C N N L H T S V R
15
V F T M I D C N N L H T+V R
1
V F T M I D C N N L H T A V R
15
86.7%
NZ_LVYL01000023.1 and 1 other:
NZ_LVYL01000023.1 Lanthipeptides: allorf_422114_422272_lanthipeptide
Lanthipeptides: allorf_422114_422272_lanthipeptide
1
V F T M I D C N N L H T S V R
15
V F T M I D C N N L H +V R
1
V F T M I D C N N L H I A V R
15
with 2 more sequence matches
80.0%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: allorf_4307377_4307535_lanthipeptide
Lanthipeptides: allorf_4307377_4307535_lanthipeptide
2
F T M I D C N N L H T S V R
15
F T M I D C N N L H +V R
2
F T M I D C N N L H I A V R
15
66.7%
NZ_JALAMS010000001.1 and 1 other:
NZ_JALAMS010000001.1 Lanthipeptides: allorf_278861_279019_lanthipeptide
Lanthipeptides: allorf_278861_279019_lanthipeptide
5
I D C N N L H T S V R
15
I D C N N L H T+V R
1
I D C N N L H T A V R
11
allorf_188984_189121
Leader:
MEREVLAYP
Core:
S F K Y R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
Core with dehydrations:
Dha F K Y R Dha Dhb L Dhb I F K R Y Dha V L Cys Dha Y P F Dhb K L L Dha F K N G H L R Dha Y

#### antiSMASH-DB 4.0 matches for allorf_188984_189121

100.0%
NZ_FOXX01000007.1 and 6 others:
NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide
Lanthipeptides: allorf_282390_282527_lanthipeptide
1
S F K Y R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
36
S F K Y R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
1
S F K Y R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
36
58.3%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: allorf_4307035_4307148_lanthipeptide
Lanthipeptides: allorf_4307035_4307148_lanthipeptide
1
S F K Y R S T L T I F K R Y S V L C S Y P F T K
24
S F K Y R T L T I F K R Y S V L C S Y P K
1
S F K Y R R T L T I F K R Y S V L C S Y P V Y K
24
27.3%
NZ_CP045729.1:
Lanthipeptides: LG045_RS07910_lanthipeptide
5
R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
36
R T L+I ++ S C +S F G L S Y
13
R V T L S I A R K S S A K C----I S W I S F S A G G L N S Y
40

#### Lanthipeptide(s) for A4U60_RS22260

A4U60_RS22240
Leader:
MEERLYGFAGKLEEELEEIALKEISGG
Core:
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
Core with dehydrations:
A E Q R G I Dha Q G N D G H Q Cys Dhb I Dhb W E Cys Dha I Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for A4U60_RS22240

100.0%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
84.4%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S Q G N D G C T I T W E C S I C P T H T C W C
2
A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
83.9%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A+ +G I S Q G N D G C T I T W E C S I C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
with 104 more sequence matches
Only the first 10 are displayed here.
81.2%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C-W C
31
A E Q R G I S Q G N D G C T+T W E C S+C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
81.2%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S Q G N D G C T+T W E C S I C P T H T C W C
2
A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
78.8%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E R G I S Q G N D G C T I T W E C +C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
75.0%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E G I S+ N D G C T+T W E C S I C P T H T C W C
2
A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
72.7%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
E R G+S Q G N D G C T I T W E C +C P T H T C W C
3
V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
71.0%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E +G+S Q G N D G C T+T W E C +C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
68.4%
NC_023073.1 and 73 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
65.8%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
A E Q R G I S Q G N D G C T+T W E C +C P T H T C+C
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
65.6%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15515_lanthipeptide
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W
30
E + I S+G N D G C T+T W E C S I C P T T C W
1
V E T K K I S K G N D G K W C T L T W E C S I C P T K T C W
30
50.0%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
4
R G I S Q G N D G H Q C T I T W E C S I C P T H T C W
30
R +S+G N G C T+T W E C I C P+H T C+
7
R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for A4U60_RS22240

25.8%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
9
G N D G H Q C T I T W E C
21
G N G C T+T E C
11
G N K G A Y C T L T V E C
23
25.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
9
G N D G H Q C T I T W E C
21
G N+G C T+T E C
13
G N N G G W C T L T K E C
25
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
15
C T I T W E C
21
C T++ E C
28
C T L S K E C
34
A4U60_RS22255
Leader:
MKKNMKAIEEVSEQELKELAGG
Core:
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
Core with dehydrations:
A E E R A I W Dhb V Dhb I P I Dha L A A Cys P Dhb Dhb Q Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for A4U60_RS22255

100.0%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
81.2%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R W T+ I P I S L A A C P T T+C A S I V S P C N
1
A E E R--W T I I I P I S L A A C P T T R C A S I V S P C N G
30
78.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04080_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N
31
A+E R W T+ I P I S L A A C P T T+C A S I V S P C N
1
A D E R--W T I I I P I S L A A C P T T R C A S I V S P C N
29
with 69 more sequence matches
Only the first 10 are displayed here.
78.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E E R W T+ I P I S L A A C P T T+C A S I V S C N
1
A E E R--W T I I I P I S L A A C P T T R C A S I V S S C N G
30
67.6%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
A E + T V T I P I S A C P T T Q C A S I V P C N+
2
A E P Q G T P T V T I P I S A A I C P T T Q C A S I V R P C N N
33
65.6%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T
21
A E E R A I W T V T I P I S L A A C P T T
1
A E E R A I W T V T I P I S L A A C P T T
21
64.7%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
2
E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N
31
+ A W T+T I P I S A A C P T T Q C A S+V P C N
4
N Q P A T W T I T I P I S A A A C P T T Q C A S V V K P C N
33
60.0%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S L A C P T T+C A S I V S P C
11
T V T I P I S L A G C P T T K C A S I V S P C K G
35
54.5%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
+E + I P+S L A C P T T+C A S+V P C N D
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N D
33
53.1%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide
Lanthipeptides: FE328_RS09035_lanthipeptide
7
W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
W T +P I S L A C P+T+C A S I P C N
3
W T S L V P I S L A I C P S T K C A S I T R P C N K
28
51.5%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
1
A E E R A I W T V T I P I S L A A C P T T Q C A S I V S P C N D
32
+E + I P+S L A C P T T+C A S+V P C N
2
S E P Q G T P A T I I P V S L A I C P T T K C A S V V K P C N G
33
50.0%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S C P T T+C A S+V P C N D
14
T V T I P I S A W G C P T T K C A S V V E P C N D
38
50.0%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
T V T I P I S C P T T+C A S+V P C N D
14
T V T I P I S A W G C P T T K C A S V V K P C N D
38

#### MIBiG 4.0 matches for A4U60_RS22255

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
V T I P I S L A A C P T T Q C A S
25
V + +S A C P T T+C S
19
V A V G V S A A F C P T T K C T S
35
18.8%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
C P T T Q C A S
25
C P T T+C S
17
C P T T K C T S
24
allorf_188622_188780
Leader:
MGFNSISFTINFYIFILIQIFSKFSERFHSENRILFA
Core:
V F T M I D C N N L H T S V R
Core with dehydrations:
V F Dhb M I D Cys N N L H Dhb Dha V R

#### antiSMASH-DB 4.0 matches for allorf_188622_188780

100.0%
NZ_LWAI01000057.1 and 1 other:
NZ_LWAI01000057.1 Lanthipeptides: allorf_188622_188780_lanthipeptide
Lanthipeptides: allorf_188622_188780_lanthipeptide
1
V F T M I D C N N L H T S V R
15
V F T M I D C N N L H T S V R
1
V F T M I D C N N L H T S V R
15
93.3%
NZ_FOXX01000007.1 and 2 others:
NZ_LWAG01000015.1 Lanthipeptides: allorf_021729_021887_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021729_021887_lanthipeptide
Lanthipeptides: allorf_282028_282186_lanthipeptide
1
V F T M I D C N N L H T S V R
15
V F T M I D C N N L H T+V R
1
V F T M I D C N N L H T A V R
15
86.7%
NZ_LVYL01000023.1 and 1 other:
NZ_LVYL01000023.1 Lanthipeptides: allorf_422114_422272_lanthipeptide
Lanthipeptides: allorf_422114_422272_lanthipeptide
1
V F T M I D C N N L H T S V R
15
V F T M I D C N N L H +V R
1
V F T M I D C N N L H I A V R
15
with 2 more sequence matches
80.0%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: allorf_4307377_4307535_lanthipeptide
Lanthipeptides: allorf_4307377_4307535_lanthipeptide
2
F T M I D C N N L H T S V R
15
F T M I D C N N L H +V R
2
F T M I D C N N L H I A V R
15
66.7%
NZ_JALAMS010000001.1 and 1 other:
NZ_JALAMS010000001.1 Lanthipeptides: allorf_278861_279019_lanthipeptide
Lanthipeptides: allorf_278861_279019_lanthipeptide
5
I D C N N L H T S V R
15
I D C N N L H T+V R
1
I D C N N L H T A V R
11
allorf_188984_189121
Leader:
MEREVLAYP
Core:
S F K Y R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
Core with dehydrations:
Dha F K Y R Dha Dhb L Dhb I F K R Y Dha V L Cys Dha Y P F Dhb K L L Dha F K N G H L R Dha Y

#### antiSMASH-DB 4.0 matches for allorf_188984_189121

100.0%
NZ_FOXX01000007.1 and 6 others:
NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide
Lanthipeptides: allorf_282390_282527_lanthipeptide
1
S F K Y R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
36
S F K Y R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
1
S F K Y R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
36
58.3%
NZ_CP063142.1 and 1 other:
NZ_CP063142.1 Lanthipeptides: allorf_4307035_4307148_lanthipeptide
Lanthipeptides: allorf_4307035_4307148_lanthipeptide
1
S F K Y R S T L T I F K R Y S V L C S Y P F T K
24
S F K Y R T L T I F K R Y S V L C S Y P K
1
S F K Y R R T L T I F K R Y S V L C S Y P V Y K
24
27.3%
NZ_CP045729.1:
Lanthipeptides: LG045_RS07910_lanthipeptide
5
R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
36
R T L+I ++ S C +S F G L S Y
13
R V T L S I A R K S S A K C----I S W I S F S A G G L N S Y
40

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.22 out of 18.16
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.45 out of 27.78
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.13 out of 20.47
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.04 out of 27.55
Confidence: medium
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

A4U60_RS22240 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 3355.4 Da
  Molecular weight: 3357.7 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3375.7 Da N = 1
A4U60_RS22255 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3233.6 Da
  Molecular weight: 3235.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3253.7 Da N = 1
    3271.7 Da N = 2
    3289.7 Da N = 3
    3307.8 Da N = 4
allorf_188622_188780 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1694.8 Da
  Molecular weight: 1695.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1714.0 Da N = 1
    1732.0 Da N = 2
allorf_188984_189121 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 4188.3 Da
  Molecular weight: 4190.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4208.9 Da N = 1
    4226.9 Da N = 2
    4244.9 Da N = 3
    4263.0 Da N = 4
    4281.0 Da N = 5
    4299.0 Da N = 6
    4317.0 Da N = 7
    4335.0 Da N = 8
A4U60_RS22240 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 3355.4 Da
  Molecular weight: 3357.7 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3375.7 Da N = 1
A4U60_RS22255 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3233.6 Da
  Molecular weight: 3235.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3253.7 Da N = 1
    3271.7 Da N = 2
    3289.7 Da N = 3
    3307.8 Da N = 4
allorf_188622_188780 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 1694.8 Da
  Molecular weight: 1695.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1714.0 Da N = 1
    1732.0 Da N = 2
allorf_188984_189121 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 4188.3 Da
  Molecular weight: 4190.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4208.9 Da N = 1
    4226.9 Da N = 2
    4244.9 Da N = 3
    4263.0 Da N = 4
    4281.0 Da N = 5
    4299.0 Da N = 6
    4317.0 Da N = 7
    4335.0 Da N = 8

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
VqsM | Regulator of quorum-sensing signalling systems

NZ_LWAI01000057.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 235,813 - 256,631 nt. (total: 20,819 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
A4U60_RS22470: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Hydrolases: deacetylase
A4U60_RS22450: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

A4U60_RS22540: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000923.3 |  | 0.40 | other (other) | paerucumarin | Pseudomonas aeruginosa PAO1
BGC0000925.5 |  | 0.39 | other (other) | quinolobactin | Pseudomonas fluorescens
BGC0000846.5 |  | 0.38 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001221.5 |  | 0.34 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0001387.5 |  | 0.31 | other (other) | nucleocidin | Streptomyces calvus
BGC0002443.3 |  | 0.30 | PKS | mycemycin C, mycemycin A, mycemycin B | Streptomyces olivaceus
BGC0000196.4 |  | 0.29 | PKS | AQ-256, AQ-270a, AQ-284a | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000193.3 |  | 0.29 | PKS | aclacinomycin | Streptomyces galilaeus
BGC0000197.5 |  | 0.29 | PKS, saccharide | aranciamycin | Streptomyces echinatus
BGC0001607.5 |  | 0.28 | other (other) | gilvusmycin | Streptomyces sp. NRRL B-1347

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000923.3 |  | 0.40 | other (other) | paerucumarin | Pseudomonas aeruginosa PAO1
BGC0000925.5 |  | 0.39 | other (other) | quinolobactin | Pseudomonas fluorescens
BGC0000846.5 |  | 0.38 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001221.5 |  | 0.34 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0001387.5 |  | 0.31 | other (other) | nucleocidin | Streptomyces calvus
BGC0002443.3 |  | 0.30 | PKS | mycemycin C, mycemycin A, mycemycin B | Streptomyces olivaceus
BGC0000196.4 |  | 0.29 | PKS | AQ-256, AQ-270a, AQ-284a | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000193.3 |  | 0.29 | PKS | aclacinomycin | Streptomyces galilaeus
BGC0000197.5 |  | 0.29 | PKS, saccharide | aranciamycin | Streptomyces echinatus
BGC0001607.5 |  | 0.28 | other (other) | gilvusmycin | Streptomyces sp. NRRL B-1347

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | squalene | C30 | acyclic | none
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
A4U60_RS22500: PT_phytoene_like
Domain 1 (14 - 254): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → squalene
  FPP → diapophytoene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 27.78 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.05 out of 18.16
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.70 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
Additional weak hits (1):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.14 out of 25.88
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_LWAI01000057.1 - Region 3 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 494,556 - 535,644 nt. (total: 41,089 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
A4U60_RS23780: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

A4U60_RS23845: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: methyltransferase
A4U60_RS23875: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: dehalogenase hydrolase
A4U60_RS23915: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

A4U60_RS23930: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

A4U60_RS23960: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Ligases: synthase
A4U60_RS23870: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001962.3 |  | 0.49 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002332.2 |  | 0.48 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001647.3 |  | 0.42 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001735.5 |  | 0.42 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0001521.3 |  | 0.41 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0002402.2 |  | 0.41 | terpene | Yossoside I, Yossoside II, Yossoside III, Yossoside IV, Yossoside V | Spinacia oleracea
BGC0002407.3 |  | 0.40 | other (other), saccharide | angustmycin A, angustmycin C | Streptomyces angustmyceticus
BGC0001267.3 |  | 0.40 | terpene | elymoclavine, Agroclavine I | Claviceps fusiformis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001962.3 |  | 0.49 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002332.2 |  | 0.48 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001647.3 |  | 0.42 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001735.5 |  | 0.42 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0001521.3 |  | 0.41 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0002402.2 |  | 0.41 | terpene | Yossoside I, Yossoside II, Yossoside III, Yossoside IV, Yossoside V | Spinacia oleracea
BGC0002407.3 |  | 0.40 | other (other), saccharide | angustmycin A, angustmycin C | Streptomyces angustmyceticus
BGC0001267.3 |  | 0.40 | terpene | elymoclavine, Agroclavine I | Claviceps fusiformis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.04 out of 27.78
Confidence: strong
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 28.14 out of 28.14
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.30 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.96 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.95 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.54 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.70 out of 29.38
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.90 out of 26.06
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.88 out of 28.14
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.73 out of 32.93
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (4):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.36 out of 29.38
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.50 out of 29.38
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.80 out of 29.65
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_LWAI01000060.1 - Region 1 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 75,328 nt. (total: 75,328 nt) Show pHMM detection rules used
Region on contig edge.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
A4U60_RS25040: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

A4U60_RS25055: 3-hydroxybutyryl-CoA dehydrogenase

smcogs
  SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: PPTase
A4U60_RS25100: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase phosphatase
A4U60_RS25050: FkbH like protein

smcogs
  SMCOG1256: FkbH like protein

A4U60_RS25060: thioesterase

smcogs
  SMCOG1004: thioesterase

A4U60_RS25070: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Ligases: ligase synthase
A4U60_RS25015: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

A4U60_RS25020: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

A4U60_RS25025: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

A4U60_RS25030: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

A4U60_RS25035: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

A4U60_RS25075: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

A4U60_RS25140: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001876.2 |  |  | 0.75 | NRPS | thalassospiramide A | Thalassospira sp. CNJ-328
BGC0001050.5 |  |  | 0.72 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0001251.4 |  |  | 0.71 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  |  | 0.71 | NRPS | epichloenin A | Epichloe festucae
BGC0000342.4 |  |  | 0.70 | NRPS | enniatin | Fusarium equiseti
BGC0002135.2 |  |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001825.4 |  |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001276.3 |  |  | 0.66 | PKS | 6-methylsalicyclic acid | Aspergillus terreus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001876.2 |  | 0.70 | NRPS | thalassospiramide A | Thalassospira sp. CNJ-328
BGC0001050.5 |  | 0.69 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0001251.4 |  | 0.68 | NRPS | epichloenin A | Epichloe festucae
BGC0001250.4 |  | 0.68 | NRPS | epichloenin A | Epichloe festucae
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0002135.2 |  | 0.67 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001276.3 |  | 0.66 | PKS | 6-methylsalicyclic acid | Aspergillus terreus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.92 out of 27.78
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.01 out of 29.25
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.71 out of 26.33
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.05 out of 18.16
Confidence: strong
Additional weak hits (4):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.03 out of 29.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.53 out of 36.54
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.62 out of 30.22
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.40 out of 30.98
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 75328:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Asn) + (Asn - ccmal - Glu) + (ohmal) + (ohmal) + (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
A4U60_RS25015: mal
PKS_AT (534..821): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 95.8%
  inactive: 91.7%
  2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 156.3
  inactive: 117.8
  Methoxymalonyl-CoA: 67.4
  Methylmalonyl-CoA: 58.0
  Propionyl-CoA: 32.8
  Isobutyryl-CoA: 27.5
  Ethylmalonyl-CoA: 23.9
  fatty_acid: 23.8
  3-Methylbutyryl-CoA: 17.9
  Benzoyl-CoA: 11.3
  Acetyl-CoA: 9.2
  2-Methylbutyryl-CoA: 9.2
  trans-1,2-CPDA: 0.0
  CHC-CoA: 0.0

A4U60_RS25020: mal
PKS_AT (1401..1687): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 83.3%
  2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 170.1
  inactive: 107.0
  Methoxymalonyl-CoA: 54.2
  Methylmalonyl-CoA: 31.9
  Propionyl-CoA: 26.1
  fatty_acid: 21.6
  Isobutyryl-CoA: 10.1
  Benzoyl-CoA: 9.2
  trans-1,2-CPDA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

A4U60_RS25025: mal
PKS_AT (520..818): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 95.8%
  inactive: 87.5%
  2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 156.2
  inactive: 98.0
  Methoxymalonyl-CoA: 67.3
  Methylmalonyl-CoA: 55.2
  Propionyl-CoA: 40.3
  Isobutyryl-CoA: 24.6
  Benzoyl-CoA: 18.8
  Ethylmalonyl-CoA: 16.1
  CHC-CoA: 13.8
  Acetyl-CoA: 12.6
  trans-1,2-CPDA: 11.2
  fatty_acid: 11.2
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

A4U60_RS25030: Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (273..673): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGMAFDASVQTPDVLVGGEVNAYGPTECTVQSSS
  Nearest Stachelhaus code(s):
    Ile DAQDLGVVDK (74% 8Å match)
    Gln DAQDLGVVDK (71% 8Å match)
  Stachelhaus code match:
    80% (moderate)

A4U60_RS25035: Asn - mal
Search NORINE for peptide: strict or relaxed
AMP-binding (477..871): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWATFDLTVTSTKLILGGEVNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

PKS_AT (1592..1880): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 70.8%
  2-Rhyd-Malonyl-CoA: 66.7%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 90.7
  inactive: 49.8
  Methoxymalonyl-CoA: 46.7
  Propionyl-CoA: 27.8
  Methylmalonyl-CoA: 26.9
  Isobutyryl-CoA: 11.6
  Benzoyl-CoA: 7.4
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

A4U60_RS25075: Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (459..850): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YSASFDLTVTSTKLIVGGEFNEYGPTEATVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

A4U60_RS25140: X
AMP-binding (15..407): X
nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NQALFGMTVCIPIAVAGGELQGYGATETSPIIAL
  Nearest Stachelhaus code(s):
    Ala DLGIVGGMIK (35% 8Å match)
    nHcp GVMTVGGRIK (29% 8Å match)
  Stachelhaus code match:
    60% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization

NZ_LWAI01000064.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 13,877 - 35,818 nt. (total: 21,942 nt) Show pHMM detection rules used
Region on contig edge.
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase
A4U60_RS26505: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: aminotransferase
A4U60_RS26485: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: deacetylase
A4U60_RS26475: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Lyases: decarboxylase
A4U60_RS26490: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002633.2 |  | 0.66 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0002683.2 |  | 0.64 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002692.2 |  | 0.64 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002469.2 |  | 0.63 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.62 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001531.5 |  | 0.59 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002305.2 |  | 0.59 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002470.2 |  | 0.57 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002633.2 |  | 0.66 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0002683.2 |  | 0.64 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0002692.2 |  | 0.64 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002469.2 |  | 0.63 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.62 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001531.5 |  | 0.59 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002305.2 |  | 0.59 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002470.2 |  | 0.57 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.77 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.47 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (2):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.16 out of 27.55
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.28 out of 32.74
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_LWAI01000066.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 9,989 - 27,692 nt. (total: 17,704 nt) Show pHMM detection rules used
Region on contig edge.
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001796.5 |  | 0.28 | NRPS | tauramamide | Brevibacillus laterosporus DSM 25
BGC0000925.5 |  | 0.28 | other (other) | quinolobactin | Pseudomonas fluorescens
BGC0000453.5 |  | 0.24 | NRPS | valinomycin | Streptomyces tsusimaensis
BGC0000274.5 |  | 0.21 | PKS | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0002432.2 |  | 0.20 | NRPS | laterocidine | Brevibacillus laterosporus LMG 15441

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001796.5 |  | 0.28 | NRPS | tauramamide | Brevibacillus laterosporus DSM 25
BGC0000925.5 |  | 0.28 | other (other) | quinolobactin | Pseudomonas fluorescens
BGC0000453.5 |  | 0.24 | NRPS | valinomycin | Streptomyces tsusimaensis
BGC0000274.5 |  | 0.21 | PKS | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0002432.2 |  | 0.20 | NRPS | laterocidine | Brevibacillus laterosporus LMG 15441

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.74 out of 28.14
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.41 out of 20.97
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.80 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.04 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.13 out of 27.78
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (5):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.17 out of 33.73
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.21 out of 39.62
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.44 out of 29.38
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.72 out of 36.54
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.37 out of 31.73
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (9988...27692)
A4U60_RS26785
  RRE type: Pantocin_Microcin_RRE
  Location: 0 - 90
  Score: 64.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MexT | Global virulence regulator
PerR | Peroxide regulator
ZuR variant 1 | Zinc-responsive repressor