LOCUS       NZ_QLTT01000001        22472 bp    DNA     linear   CON 17-JAN-2024
DEFINITION  Lentzea atacamensis strain DSM 45479 Ga0215649_101, whole genome
            shotgun sequence.
ACCESSION   NZ_QLTT01000001
VERSION     NZ_QLTT01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Lentzea atacamensis
  ORGANISM  Lentzea atacamensis
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 1839004)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1839004)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Expected Final Version            :: No
            Genome Coverage                   :: 111.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/17/2024 11:04:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,181
            CDSs (total)                      :: 9,101
            Genes (coding)                    :: 8,972
            CDSs (with protein)               :: 8,972
            Genes (RNA)                       :: 80
            rRNAs                             :: 6, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 6 (5S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 129
            CDSs (without protein)            :: 129
            Pseudo Genes (ambiguous residues) :: 0 of 129
            Pseudo Genes (frameshifted)       :: 27 of 129
            Pseudo Genes (incomplete)         :: 107 of 129
            Pseudo Genes (internal stop)      :: 5 of 129
            Pseudo Genes (multiple problems)  :: 10 of 129
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:43:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1798213
            Orig. end                         :: 1820685
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QLTT01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22472
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="8"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22472
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22472
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12472](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12472
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(743..2836)
                     /locus_tag="C8D87_RS08525"
                     /old_locus_tag="C8D87_1011732"
     CDS             complement(743..2836)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103554.1"
                     /locus_tag="C8D87_RS08525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011732"
                     /product="transglycosylase domain-containing protein"
                     /protein_id="WP_233441982.1"
                     /transl_table=11
                     /translation="MVKLLGLCLTAGVLLAAMVFPFVGGLGLASNRAADTVDQTSGDLA
                     KGELPLVTTIQDMNGDPIAYLYDQYRIPLASSDISDTMKAAILAIEDKRFYDHRGVDWQ
                     GIARAAAKAGVDGGATQGASTLTQQYVKNYMAFVLGADNEQEAWEKATEATIGRKMREA
                     RVALQLEQQMSKEEILTGYLNIVPLGNQTYGVGAAAKAYFKTTADKLTVPQAALLAAIA
                     NRPSSLNPGASPEKALERRNIVIDKMRENGAFGADQTEAQKKAEEYKAAPLGVVDDLQI
                     LPKGCVGAGDGPIYGFFCSYLLDYLRESGITNKELQRGGLTIKTTMDPKATKAAKQSAE
                     QQVPKTQNGISNVMSVVEPGKDKHRVRALVASRDYGNKAELGQVARPVPAEVLPFGPGS
                     VNKVFTAAAALEKGVIGIDKEMAVPKVYYSRVYPNGGAPWKVENAGTYGEKMSLTQALA
                     QSPNTGFVILQEKTGLDSVVDMAYRLGMRETLQGVNRAGEPLKDDKSNGPSQGDWTKQN
                     NAGSYTLGPGATSVLELANVAATIVSGGTWCPPSPVEKVIDRYGKEVPLKEKPCEQAVN
                     TELANSLAQGMSHDTTGQGTAAQAASGSGWNRPTIGKTGTTEEHKSVAFMAATPQYAGA
                     VMTYADGNRPEVICANPIRFCPGSNQGVYGGQVAAPTWFNAMKVIHEGLPVVPLPPAAA
                     RYK"
     gene            complement(2957..3985)
                     /locus_tag="C8D87_RS08530"
                     /old_locus_tag="C8D87_1011733"
     CDS             complement(2957..3985)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103555.1"
                     /locus_tag="C8D87_RS08530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011733"
                     /product="PfkB family carbohydrate kinase"
                     /protein_id="WP_112226150.1"
                     /transl_table=11
                     /translation="MADPDFDVLLTGTVFLDIIFTGLPRPPAAGTEVWAEGLGSCPGGI
                     ANLAVALRRLELRTALAAAFGEDAYGDFCWDVLSEQEGVDLSYCRRFYGWHSPVTVSMA
                     MERDRSMVTHGHKAPVIADDLFCPPPSTRACFVHIQAEDEQWVRTAKENGALLFADIGW
                     DRTGAWSPELLRRLEGYDVFLPNHVEAQGYTRTDSPEAAARKLSEHVPVVVVTRGGGGA
                     VAVDSSTGEVADVPGLNVAQLDPTGAGDVFGAGFVMGTLAGWPLEHRVRFANLCAALSV
                     QHFGGSLSAPGWGDIAVWWRTVSRRPDEELARYGFLDDVLPDHAGVEVRRASPTIGLRL
                     LR"
     misc_feature    3985..4001
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    3986..3999
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.31"
                     /tool="antismash"
     gene            4038..5234
                     /locus_tag="C8D87_RS08535"
                     /old_locus_tag="C8D87_1011734"
     CDS             4038..5234
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="C8D87_RS08535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011734"
                     /product="MFS transporter"
                     /protein_id="WP_170166355.1"
                     /transl_table=11
                     /translation="MGVPLRKNVQFQLLWLGGTVSQLGTQLTTYAMPLLILAVTGSFFW
                     AGVIAGVRATTLILTQMPAGVWVDRWDRGKVLVWSQTTQAVAVAAMAANVVTGLNSIPL
                     FIALAAVDGVCTAFAGPARSTAIKAVVPPDQLRTAFAQEEARGHVAWLAGPSLGALLYG
                     FGRAVPFVADAVTFLVAAVCAWFAKIPARTEQRPRGRVRHDVREAWTWLWRRRGMRNVV
                     AIFLTLNLLGTASMIPVVAVVKERGGPDWLVGLVLTGVGVGGLLGALISPKVTLRYDRL
                     IVAVLTVFGVSNLAMALPFGAWWPFVPLMVTAIATPLLNVSVSAIFTGLVPDDLMGRID
                     AILTFASRALTPLAPVLGAFLADLAGGALALLVFGALILVTALVAAFTDLRAPAPQQS"
     gene            complement(5197..5649)
                     /locus_tag="C8D87_RS08540"
                     /old_locus_tag="C8D87_1011735"
     CDS             complement(5197..5649)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-144). E-value:
                     8.7e-12. Score: 37.6. Matches aSDomain:
                     nrpspksdomains_C8D87_RS08540_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644362.1"
                     /locus_tag="C8D87_RS08540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011735"
                     /product="SRPBCC family protein"
                     /protein_id="WP_233441983.1"
                     /transl_table=11
                     /translation="MITGIAAPPHRVFDLSLDVDVHTASMAGSGERIVGGISSGRMGPG
                     DTVTWQAGHFGVRWRMTSCITALDRPHHFVDEQVAGPFRRWHHAHHFEPDGRGGTRMRD
                     VVEFAAPLGPLGRLAERLVLDRYMAELIRQRNDHLRTVAELAPGDP"
     aSDomain        complement(5218..5637)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C8D87_RS08540_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="8.70E-12"
                     /label="C8D87_RS08540_Polyketide_cyc2.1"
                     /locus_tag="C8D87_RS08540"
                     /protein_end="144"
                     /protein_start="4"
                     /score="37.6"
                     /tool="antismash"
                     /translation="IAAPPHRVFDLSLDVDVHTASMAGSGERIVGGISSGRMGPGDTVT
                     WQAGHFGVRWRMTSCITALDRPHHFVDEQVAGPFRRWHHAHHFEPDGRGGTRMRDVVEF
                     AAPLGPLGRLAERLVLDRYMAELIRQRNDHLRTVAE"
     misc_feature    5600..5615
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.25"
                     /tool="antismash"
     gene            complement(5675..6967)
                     /locus_tag="C8D87_RS08545"
                     /old_locus_tag="C8D87_1011736"
     CDS             complement(5675..6967)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228237.1"
                     /locus_tag="C8D87_RS08545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011736"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_112226152.1"
                     /sec_met_domain="MGT (E-value: 1.6e-44, bitscore: 149.5,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASLIIATVPVHGHVTPLLAVARYFTQRGDRVRFITGSRFAEVVE
                     AAGAEHIALPAEADFDDRQDFGVTFPERTALKGAKAIAFDLENVFVRPGRAHYKVIEAA
                     QSAEPADVVITEPAFLGGAFLVCRPLGERPPVVVCGVLPLPISSRDTAPYGMGLTPLRG
                     PLGRLRNALLTNIAARTVFTAAERLAQEINHELNGSPLPFPIMDWLRHAEAIVQFTVPE
                     FEYPRSDAPATLHFAGPISASGSQAPLPSWWDELDGSRPVVHVTQGTVANHDYRQIIEP
                     SLAALADDDVLVVVSTGGRPLSTLPPLPSNARAAEYLPYDELLPKTQVYVTNGGYGGVQ
                     YALRHGVPIVTSGGKEDKPEVAGRVVWSGVGRALRTETPSPAAVGRAVRAVLGDPRYRV
                     RARRIAASMERAGGLSRLAEIVDRQLSGRRS"
     gene            7056..7721
                     /locus_tag="C8D87_RS08550"
                     /old_locus_tag="C8D87_1011737"
     CDS             7056..7721
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228236.1"
                     /locus_tag="C8D87_RS08550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011737"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_112226351.1"
                     /transl_table=11
                     /translation="MTESTRPYRSELRRRQAAETRRRVVEAAAELFSRQGYQATTFAQL
                     ATAAGVSVETVQRHGPKSALLQAALELVSFGVEGETDLLATDLGKAMLQVSGTAELAAL
                     IGDAMLAINAPSAGLWVAVASAAQGDEELRGYYAANLALLRRQVEHVFHVFAERGWLRA
                     DVPFDDLVEAFCVITSVEAYVRFVRLDGKPDDTYAAFVARTVGETILSPPLRSSPASG"
     gene            complement(7684..8370)
                     /gene="shbA"
                     /locus_tag="C8D87_RS08555"
                     /old_locus_tag="C8D87_1011738"
     CDS             complement(7684..8370)
                     /codon_start=1
                     /gene="shbA"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103556.1"
                     /locus_tag="C8D87_RS08555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011738"
                     /product="RNA polymerase sigma factor ShbA"
                     /protein_id="WP_233439415.1"
                     /transl_table=11
                     /translation="MVQPTAVRTGGGVGVLDPEEVWNQPTVPMRRRVRQAPVSNQWLAE
                     AEFTDLVDAALDGDRRAVEHLLGRIQPLIVRYCRARVGGRERTLVSAEDIAQEVCVAVL
                     GALSKYRYEPQSFLAFVYGIAAHKVADARRRAVRNRAEVVPELPDCPSLDDGPEQHAVN
                     GEMMAQVTRLLHKLPARQREILVLRVAVGLSAEEVALAVESTPGAVRVAQHRALTRMRE
                     MIAEEG"
     misc_feature    8923..8938
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.47"
                     /tool="antismash"
     gene            8931..9755
                     /locus_tag="C8D87_RS08560"
                     /old_locus_tag="C8D87_1011739"
     CDS             8931..9755
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (25-257). E-value:
                     8.8e-22. Score: 69.8. Matches aSDomain:
                     nrpspksdomains_C8D87_RS08560_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642197.1"
                     /locus_tag="C8D87_RS08560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011739"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_112226352.1"
                     /sec_met_domain="PF00561 (E-value: 6e-16, bitscore: 55.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-15, bitscore:
                     55.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDHLSIETEAGTFDAIASGPEDGRPVLLLHGFPEAAIEWEHQVA
                     VLGANGFRAVAPDQRGYSPGVRPEQSSEYTVTHLVGDVIAMADAQGWSTFDLVGHDWGG
                     AVAWWTAIDHPDRLRTLSVFSTPHPGALKTALRTDEEQRMRSQYMLDWRERSTERRMLE
                     NNAHALRQMFEYRIRPSHVDEYIQRLSEPGALSAALNWYRAGKPSGAADKVAVKTMYVW
                     STEDVAFGSVAAFETEKWCTGPYRFEMVEDVSHWIPEEIPEAASSLLLEHLS"
     aSDomain        9006..9701
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C8D87_RS08560_Abhydrolase_1.1"
                     /evalue="8.80E-22"
                     /label="C8D87_RS08560_Abhydrolase_1.1"
                     /locus_tag="C8D87_RS08560"
                     /protein_end="257"
                     /protein_start="25"
                     /score="69.8"
                     /tool="antismash"
                     /translation="PVLLLHGFPEAAIEWEHQVAVLGANGFRAVAPDQRGYSPGVRPEQ
                     SSEYTVTHLVGDVIAMADAQGWSTFDLVGHDWGGAVAWWTAIDHPDRLRTLSVFSTPHP
                     GALKTALRTDEEQRMRSQYMLDWRERSTERRMLENNAHALRQMFEYRIRPSHVDEYIQR
                     LSEPGALSAALNWYRAGKPSGAADKVAVKTMYVWSTEDVAFGSVAAFETEKWCTGPYRF
                     EMVEDVSHWI"
     gene            9883..9984
                     /locus_tag="C8D87_RS08565"
                     /old_locus_tag="C8D87_1011740"
     CDS             9883..9984
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039305.3"
                     /locus_tag="C8D87_RS08565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011740"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_109635407.1"
                     /transl_table=11
                     /translation="MYETPQLIDLGTFEAQTGLLQRNGNDRLIFSKN"
     gene            10001..11830
                     /locus_tag="C8D87_RS08570"
                     /old_locus_tag="C8D87_1011741"
     CDS             10001..11830
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="C8D87_RS08570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011741"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_112226153.1"
                     /sec_met_domain="Asn_synthase (E-value: 7.4e-43, bitscore:
                     144.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDQASRGHGESHFVVLPDHEAALAVARRLCAPGFRSLQHASGRP
                     WLAGRWRDDEIVAAAAGDARLAVIGWCPVSVAELERAAAGLRDLTHLDELARRLPGSFH
                     LVASLGGRCRVQGTASGLRLVFHRRIGEVVVAADRADLLAQDSPVDERGLVVRLLFPTP
                     HPLLERTMWRDVECVPPGSALLVDGGRARLTRWWRDPEPVRGIAESVPLIRDALATAVD
                     VRTRAGGTVACDLSGGLDSTSITFLAARSDARIVASTWPALDPVDEDVAWARRAAAHLP
                     MVEHVVWPAERIPLVYENLLGIDDPMDEPTIGMMDRQRLLEDLKGLAEKGSRVRLTGIG
                     GDHVAWCSEAHYHPLLRRRPLFAIRQLRAFRALFDWPLKPMISALADSRSYGAWLADEA
                     ERLRAPRDPNVIGTLGWGTGPRLFDWVTPEAQALARDTLLDAAATAEPLGRNRGEHGDL
                     EPILSCSRIIRQWEQMSARAGLPIQSPFLDDRVIEACLSVRPEERVTPWRYKPVLTEAM
                     RGIVPDECLARTNKAQAALEASAGLRRHRGDLLELWESSKLADLGLVDRRRLTELALRP
                     DTPELRTGILYSTIGCEVWLRSLDKGAEHAVAG"
     aSDomain        11814..12059
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C8D87_RS08575_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.90E-30"
                     /identifier="RREFam002.1"
                     /label="C8D87_RS08575"
                     /locus_tag="C8D87_RS08575"
                     /protein_end="82"
                     /protein_start="0"
                     /score="94.7"
                     /tool="antismash"
                     /translation="MRLRADVSVADTDYGQVLLDERSGRYWQLNPTGVAVVRALLEGAD
                     ENAAVAALTSAYEVDEARARQDVSALVAGLRTAGLVT"
     gene            11814..12065
                     /locus_tag="C8D87_RS08575"
                     /old_locus_tag="C8D87_1011742"
     CDS             11814..12065
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670106.1"
                     /locus_tag="C8D87_RS08575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011742"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_109635403.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.5e-28,
                     bitscore: 94.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 3.6e-07,
                     bitscore: 26.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.8e-16, bitscore: 57.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRADVSVADTDYGQVLLDERSGRYWQLNPTGVAVVRALLEGAD
                     ENAAVAALTSAYEVDEARARQDVSALVAGLRTAGLVTT"
     gene            12062..12472
                     /locus_tag="C8D87_RS08580"
                     /old_locus_tag="C8D87_1011743"
     CDS             12062..12472
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670107.1"
                     /locus_tag="C8D87_RS08580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011743"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_109635401.1"
                     /sec_met_domain="PF13471 (E-value: 5.3e-27, bitscore: 90.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSSLSRPTGVPLRRRIAARLAVTAATPLAHLKPRTLRRILSL
                     LRRGAKPAPYDTAKAARDAVLAVSLRCLGPQGCLPRSVAVALLCRMSGTWPTWCAGVRV
                     MPPFGAHAWVEADGVPVDENLPAQYFRPLMTV"
     gene            12469..14205
                     /locus_tag="C8D87_RS08585"
                     /old_locus_tag="C8D87_1011744"
     CDS             12469..14205
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="C8D87_RS08585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011744"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_112226154.1"
                     /transl_table=11
                     /translation="MRTLDLLRLASGHGRGLALAVTATLVAAGLGLLQPQLLRAAVDSA
                     TSVPWQLLAAMAVLFLAQACVDGAGLYLLERTGERVVLGVRRRLVARLLRLRMKAFDEH
                     RVGDLMSRVSVDTTVLREVVSTASVQLITGTLTGVGTVVLMVLIDPVLFLWVGTTVVVA
                     AVVVYSLVGRLRAAGEQMQRGVGDMTAELERALGALRTVRACRAEEREEELIGRRAEQA
                     CAAGVRAARITSVMSPAVELAMRGSLLVVLLVGGTRVARDAASVGDLMAFLLYATYLII
                     PFTSVLQGIGLLQKGMGALGRVAEVQELPVEGTAGGVVPECAGIRLEFRDVWFRYRDRP
                     VLRGVSFTVEPRSHVALVGLSGAGKSTLFSLIERFYEPDSGALLANGIDIRNFSRDQWR
                     ARIALVDQDSTVLNGTLRDNLSYAAPHSSDHDLHEVLELANLTELVERLPDGLDTPLGE
                     RGRALSGGERQRIALARALLTQPDLLLLDEPTAHLDPVNERALHRAIHQAAQECALLVI
                     AHRLSTIREANRIVVLRAGEVIAQGTHDELLGINGFYSGLAGGRFVDNSKLFETEISPG
                     WR"
     gene            14335..14904
                     /locus_tag="C8D87_RS08590"
                     /old_locus_tag="C8D87_1011745"
     CDS             14335..14904
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="C8D87_RS08590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011745"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_112226155.1"
                     /transl_table=11
                     /translation="MRTLDHLVTRSAAVRAVLSSRGGIDSALLGLMSNAADRGRLLLDP
                     PLARHTETIGRVARHHVDIRVHTQPARHMLVFDDRAAVLPLDASDLNTGAVLLRCPLST
                     PYGQLFELMWSDAETLSENAPPPDGLTSREAEVIGLLLNGATDHQVAARLGMSSRTVRA
                     VVAHLQQRFGTRSRMALGFQIARSTN"
     gene            14979..16133
                     /locus_tag="C8D87_RS08595"
                     /old_locus_tag="C8D87_1011746"
     CDS             14979..16133
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663884.1"
                     /locus_tag="C8D87_RS08595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011746"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_112226156.1"
                     /transl_table=11
                     /translation="MTTSRRDFVRLGGAALAGGVALGTGTASAKERIDWSVEVVESTMR
                     QFTPETLGGWGYTRGLYLWGQWLVFQRTKNKKYFDYVKAWVDRFVGPDGKFNRTFTHLD
                     SMRAGQLLPLLYNATGDVRYRVASTQIRERLNTYSRTKEGGFWHAEGGTRDWQNWSDGV
                     YMVVPFIMRHGYTFGEKDWATAEALRQLLVYAKNLQHKDGLFHHAYDESRTASWANPAT
                     GVSPEFWGRAMGWYAITCCDVLEDLPRTHPDRPKLISILGRLIAALARHQDPKSGRWFQ
                     VVDKGSNPRNWTETSCSSMYSMAISRAVERGYVSRRYEVVAQRGYRGVLERVSINAQGS
                     TEISEICIGTNVGDLPFYLARPRAVNDLHGIGAFLIMSEQFQRR"
     gene            16144..16719
                     /locus_tag="C8D87_RS08600"
                     /old_locus_tag="C8D87_1011747"
     CDS             16144..16719
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103563.1"
                     /locus_tag="C8D87_RS08600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011747"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_112226157.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.1e-38, bitscore:
                     129.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVAGLLLAAGAGRRFGSPKALVSLHGKLFVDSAAELLRAAGCEP
                     VVVVLGAMADEVRAKASLDGVTVVDNPDWESGMGSSLRTGLHAAGIVDAVVVLPVDTPG
                     VTVAALHRLMELAEPKALARAVYDGKVGHPVLIGSDHFAGVMASAAGDQGARDYLKANT
                     VRHVECADVADGADVDRPEDLRPRNGEA"
     misc_feature    16255..16257
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16694..17302)
                     /locus_tag="C8D87_RS08605"
                     /old_locus_tag="C8D87_1011748"
     CDS             complement(16694..17302)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024919.4"
                     /locus_tag="C8D87_RS08605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011748"
                     /product="C39 family peptidase"
                     /protein_id="WP_112226158.1"
                     /transl_table=11
                     /translation="MKLARITGAVAAVGVAMTIFTAPVALAAPGETVIPAAAELGIQGE
                     GVLPHEFQVQKTGYWCSAAAARIALTARCKEVEQSTLASYMKVTTNGLPNIKNLESALD
                     HYTGSTYYQVKQWSTDAQLLQKLKADVVYNASRGHAVVINVIRLNGRNYSGGHYATVVG
                     YRAGGNEFAVADPAYAGGRLHWLSASNVSSGIKLRRYVA"
     gene            17467..17688
                     /locus_tag="C8D87_RS46825"
                     /old_locus_tag="C8D87_1011749"
     CDS             17467..17688
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D87_RS46825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D87_1011749"
                     /product="hypothetical protein"
                     /protein_id="WP_215732214.1"
                     /transl_table=11
                     /translation="MLRVHFPAEDLARVRVAPGPDPMWEILLSLHVLRQRSATPVFGTW
                     RANVRSTLPDDARWLMQLAPPVGYSPTS"
     gene            complement(18140..18370)
                     /locus_tag="C8D87_RS46830"
     CDS             complement(18140..18370)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D87_RS46830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215732215.1"
                     /transl_table=11
                     /translation="MCRTELRCRWATARPASRRTEAWALADAAERPRRRASSVVVQPPA
                     MTPSAAARVRPRSASSERLPLVVMWRSRAIG"
     gene            complement(18375..19361)
                     /locus_tag="C8D87_RS08615"
                     /old_locus_tag="C8D87_1011750"
     CDS             complement(18375..19361)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673451.1"
                     /locus_tag="C8D87_RS08615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011750"
                     /product="phosphotransferase"
                     /protein_id="WP_112226353.1"
                     /sec_met_domain="APH (E-value: 1.3e-20, bitscore: 71.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAESHAPVVEMLWEAHDPLGALGGRFGFGDERAAGRWVATALGEH
                     WGVRVLSCERIVISDHNALAWVGTPEGRMIAKWSVVPELFARLVEVARLTRWLDGRGIP
                     VSVPVPALDGRLQVEVAGASMGLQHEVEGELLDVTDAGQVREAGAVLARLQDALAAYPD
                     GDRVAAFGGPPLPLTARVTGWLDSSAGHLPGTAREALRSMLGGVPAGRLRAQLVHRDFR
                     SANVLWAGGEVAAILDFEEIALDHRVVELARSAVLLGTRFRDWGPVPAEVHAAFLAGHE
                     SVRRLTEVEAGWWEVLLRWHALAMVPEGEDPTGWGAAALGEEFHAQR"
     gene            complement(19382..19558)
                     /locus_tag="C8D87_RS45770"
                     /old_locus_tag="C8D87_1011751"
     CDS             complement(19382..19558)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D87_RS45770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D87_1011751"
                     /product="hypothetical protein"
                     /protein_id="WP_215732216.1"
                     /transl_table=11
                     /translation="MIRRYFYIWVVLAAVFTTAGATHIALAITYSVLWPVWVAMAQLVV
                     AGGCARAAVRTRP"
     gene            19667..20407
                     /locus_tag="C8D87_RS08625"
                     /old_locus_tag="C8D87_1011752"
     CDS             19667..20407
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103566.1"
                     /locus_tag="C8D87_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011752"
                     /product="SIS domain-containing protein"
                     /protein_id="WP_109635383.1"
                     /sec_met_domain="SIS_2 (E-value: 2.6e-39, bitscore: 131.1,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDTVTGSDYGNLVRTHLTRVEQHNAAALDDVAELVLAAVQADG
                     MILTAGAGHSLAAVAETFYRAGGLACVRPIYHPELLPMHGAISSTAAERRSGLAGEVLR
                     EAGLAPHDVLFVFSTSGVNHYPVELAQEAAGAGCPVVAVTSVTASAQAPRRAGATLAEV
                     ATVVLDNLVPPGDSTYPEQAPVTAAVSTLATTFLWNLLMVRLVDKATETGVQLPLWRSA
                     NVEGGDAANADLLRHYQTRIPQLG"
     gene            20488..22056
                     /locus_tag="C8D87_RS08630"
                     /old_locus_tag="C8D87_1011753"
     CDS             20488..22056
                     /GO_function="GO:0008658 - penicillin binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013100.4"
                     /locus_tag="C8D87_RS08630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D87_1011753"
                     /product="penicillin-binding transpeptidase
                     domain-containing protein"
                     /protein_id="WP_170166356.1"
                     /transl_table=11
                     /translation="MEPKTRRWILIGGALATATTIGVAGALLWSPDPVISEKPKNQANQ
                     SVERPADVALSFVNKLSSSDAAAAAQLTDAPDAAAKAIAATRTGMAASAYQARLAATTP
                     PAPDATTTDLTASVTWTMPSSAVLKYDVKLTVQKSGEAWKVHWTPTLLHPQLTEGSSLV
                     YRAALADGALLGRDGKPLVKGTIPDGLYNTITGQTGDLKGTDGWEVGISSTAGFTKLDG
                     KAPEGGQKITVTIDPARQAAAQAAVDALPQGAAIVAIEPSTSEILAVAQNKTLSGTNPF
                     VGRYAPGSTMKIVTAAAAMNAGLVQANTAVPCPATATIGTRRISNAGFGHDSLPFHTAF
                     ALSCNTTMGELGAKLPPNALPDMAKRFGLGADWTITGADTNTGKVPPASGDQQVENSFG
                     QGNVVASPFGMALVAATVVSGKTPTPTLMRGKPPTPNDVAAAPPAATLQPLRNMMREVV
                     TTGTAKQLSGIPGLAGKTGTAEAGGGTAHGWFVGYQGNMAFAVFVENAGSSQSALTATA
                     AFLKR"
     misc_feature    22078..22093
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    complement(22202..22215)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
ORIGIN
        1 cgatgccgtg ccaaaactgc ctccatgcac tcgggggagt tcggctaacc gctggtgtgc
       61 ctcggcttcg ggggccgggc gtggtgcagg gcgtgttggt gctctgcggc gggctgggga
      121 ggccctgtcg gactggaccg tttcggggga gatccgtgtc cttgcggtta tcgaaccgtg
      181 acatgcagcg gtgaacgtaa cctcgcgtca ccgacaggag caagccaagt gggcatttag
      241 gtgatgaggg ccacgattgg taacacaccg tagttgagtc gtggtggggt tgatcaacgg
      301 gctttagacc aatcccgttc ttggcgtttg tactggtcag tcgctttatc gtgaaagctt
      361 tgcggctggg tttggctgga caggtgcggc tgcgtggtta cgaggcgtgc ttggctcgtt
      421 gcggggtcgc ctttggggct cgcgcttggt gcggggtggt tgcgcggggc tgctggcggc
      481 tgttccagcg gaggggttcg tgctgtgcgt cggctcccct tgagcaggtg gcgcgcgggc
      541 cgttaccgag ctttggttgc gtcaacaagg ccacagcgga gtgcgcacgg cccaacgggc
      601 gccctccacc cgccacagct cccacccagt gcgccaccag cggggtacgc gaccctgcca
      661 agcgccaccc actcaccacc tggacaaagc aaagggccgt cggacgcatc tggcgtccga
      721 cggccccgca atcaatcagg ctctacttgt accgggcggc cgctggtggc agcggcacca
      781 ccggcaggcc ctcgtggatc accttcatcg cgttgaacca cgtcggagcc gctacctggc
      841 cgccgtagac gccctggttg ctgcccgggc agaaccggat cgggttggcg cagatcacct
      901 cggggcggtt gccgtcggcg taggtcatga cagcgcccgc gtactgcggg gtggcggcca
      961 tgaaggcgac ggacttgtgc tcttcggtgg tgccggtctt gccgatggtc gggcggttcc
     1021 agccggagcc ggaggccgcc tgggccgcgg tgccctggcc ggtggtgtcg tgggacatgc
     1081 cctgggccag ggagttggcc agttcggtgt tcacggcctg ctcgcagggc ttttccttga
     1141 gcgggacttc cttgccgtag cggtcgatga ccttctccac cggggacggc gggcaccagg
     1201 tgccgccgga gacgatggtg gcggcgacgt tggccagttc gaggacgctg gtggcgccgg
     1261 ggccgagggt gtaggagccc gcgttgttct gcttcgtcca gtcgccctgg gacgggccgt
     1321 tggacttgtc gtccttcagc ggttcgcccg cgcggttgac gccctggagg gtttcgcgca
     1381 tgccgaggcg gtaggccatg tccacgacgc tgtcgaggcc ggtcttctcc tgcaggatca
     1441 cgaagccggt gttcggcgac tgcgccaggg cctgggtcag cgacatcttc tcgccgtagg
     1501 tgccggcgtt ctcgaccttc cacggcgcgc cgccgttggg gtagacccgc gagtagtaga
     1561 ccttcgggac cgccatctcc ttgtcgatgc cgatgacgcc cttctccagc gcggccgcgg
     1621 cggtgaagac cttgttcacc gagccggggc cgaacgggag gacctcggcg ggcacagggc
     1681 gggcgacctg gccgagctcg gccttgttgc cgtagtcgcg ggaggcgacg agggcgcgca
     1741 cgcggtgctt gtccttgccc ggctcgacga cggacatgac gttcgagatg ccgttctggg
     1801 tcttcgggac ctgctgctcg gccgactgct tcgccgcctt ggtggccttc gggtccatcg
     1861 tcgtcttgat ggtgaggccg ccgcgctgca gttccttgtt cgtgatgccg gactcccgca
     1921 ggtagtcgag caggtaggag cagaagaagc cgtagatcgg gccgtcaccg gcgccgacgc
     1981 agcccttggg caggatctgc aggtcgtcga ccacgcccag cggcgcggcc ttgtactcct
     2041 cggccttctt ctgggcctcg gtctggtcgg caccgaacgc gccgttctcg cgcatcttgt
     2101 cgatgacgat gttgcgacgc tccagcgcct tctccggcga ggcgccgggg ttgagcgacg
     2161 acgggcggtt cgcgatcgcg gccagcagcg cggcctgcgg gacggtcagc ttgtcggcgg
     2221 tcgtcttgaa gtaggccttg gccgcggcgc ccacgccgta ggtctggttg cccagcggca
     2281 cgatgttcag gtagccggtg aggatctctt ccttcgacat ctgctgctcg agctgcaagg
     2341 cgacccgcgc ctcgcgcatc ttgcggccga tggtcgcctc ggtggccttc tcccaggctt
     2401 cctgctcgtt gtcggcgccg agcacgaacg ccatgtagtt cttgacgtac tgctgcgtca
     2461 gcgtcgaggc gccctgcgtc gcgccaccgt ccacaccggc cttggcggcg gcacgggcga
     2521 tgccctgcca gtcgacgccg cggtggtcgt agaaccgctt gtcctcgatc gcgaggatcg
     2581 cggccttcat ggtgtccgag atgtcgctcg acgccagcgg gatgcggtac tggtcgtaca
     2641 gataggcgat cgggtcgccg ttcatgtcct gaatggtcgt gacgagaggc agctccccct
     2701 tggcgaggtc acccgacgtc tggtcgacgg tgtcggcagc gcggttggac gcgagcccga
     2761 gacctccgac gaacgggaac accatcgcag cgaggagcac gcccgccgtc aggcacaacc
     2821 ccagcaattt gaccaagcct gacgcgcgtg cggcgaacaa acccgcaact ccttccgagc
     2881 aacaccccag agatccctac ttataagtcg cgcgggaggc ccgtgaggtt gcgtccgctg
     2941 atcgactgat ttcaacctac cggagcaacc ggaggccgat cgtcggacta gcccttcgca
     3001 cctccacgcc cgcgtggtcg ggcagcacgt cgtcgaggaa cccgtaccgc gccagctcct
     3061 cgtccggcct cctgctcacc gtccgccacc agaccgcgat gtctccccag ccgggagccg
     3121 acagcgaacc gccgaagtgc tgcacggaca gcgcggcgca caggttcgcg aaccgcaccc
     3181 tgtgttccag cggccacccg gccagagtgc ccatcacgaa cccggcgcca aacacgtcac
     3241 cggctcccgt cgggtcgagc tgcgcgacgt tcagccccgg cacgtccgcg acctcaccgg
     3301 tggagctgtc gaccgcgacc gcgccacctc ccccgcgtgt gaccaccacc accggcacgt
     3361 gctcggaaag cttgcgcgcc gcggcctccg gcgagtcggt gcgcgtgtac ccctgcgcct
     3421 ccacgtgatt cgggaggaac acgtcatatc cctccagccg ccgcagcaac tccggcgacc
     3481 acgccccggt gcggtcccag ccgatgtcgg cgaagagcag cgcgccgttc tccttggccg
     3541 tgcgcaccca ctgctcgtcc tcggcctgga tgtgcacgaa gcacgcccgc gtcgacggcg
     3601 gcgggcagaa gagatcgtcc gcgatcacgg gcgccttgtg gccgtgcgtg accatcgaac
     3661 ggtctcgctc catcgccatg gacacagtca ccggcgagtg ccacccgtag aaacgccggc
     3721 aataagaaag gtcgacccct tcctgttcgg acagcacgtc ccagcagaag tcgccgtacg
     3781 cgtcctcacc gaacgccgcc gccagcgcgg tccggagctc cagcctgcgc aacgccaccg
     3841 cgaggttcgc gatccctccc ggacacgacc cgagcccctc cgcccacacc tctgtccccg
     3901 cggccggcgg gcgcggcagg ccggtgaaga tgatgtcgag gaagaccgtg ccggtgagca
     3961 gcacgtcgaa gtccggatca gccatggcac aaaccttgcc atccgacacc ggcaaccatg
     4021 cgctagaaac gtcgtccatg ggggttccgc tcaggaagaa cgttcagttc cagctgctct
     4081 ggttgggcgg gacggtctcg cagctgggca cgcagctcac gacgtacgcg atgcctctgc
     4141 tgatcctcgc ggtcaccgga tcgttcttct gggccggcgt catcgcgggc gtgcgcgcca
     4201 cgacactgat cctcacccag atgccggcgg gcgtgtgggt cgaccgctgg gaccgcggca
     4261 aggtcctggt ctggagccag acgacgcagg ccgtggccgt cgctgcgatg gcggccaacg
     4321 tcgtcaccgg cctcaactcg attccgctgt tcatcgcgct ggccgccgtg gacggcgtct
     4381 gcaccgcgtt cgccggtccc gcccgctcca ccgcgatcaa ggcggtcgtg cccccggacc
     4441 agctcaggac cgccttcgcc caggaggagg cacgcggtca cgtggcgtgg ctcgccggcc
     4501 cgtcgctcgg cgcgctgctc tacgggttcg gccgcgctgt cccgttcgtc gcggacgccg
     4561 tgacgttcct cgtcgccgcc gtctgcgcct ggttcgccaa gatcccggcc cgcaccgagc
     4621 agcggccgcg cgggcgcgtg cgccacgacg tccgcgaggc ctggacctgg ctgtggcgcc
     4681 gccgcgggat gcgcaacgtc gtggcgatct tcctgacgct caacctgctc gggacggcct
     4741 cgatgatccc ggtcgtcgcc gtggtcaagg aacgcggcgg cccggactgg ctcgtcggcc
     4801 tggtgctcac cggcgtcggc gtcggcggtc tgctcggggc actgatctca cccaaggtca
     4861 ccctgaggta cgaccggctc atcgtcgcgg tgctcacggt cttcggcgtg agcaacctgg
     4921 cgatggcact gccgttcggg gcgtggtggc cgttcgtgcc gctcatggtc accgcgatcg
     4981 cgacaccgct gctcaacgtc tcggtgagcg cgatcttcac agggctggtg cccgacgacc
     5041 tgatggggcg gatcgacgcg atcctgacct tcgcctcgcg agcgctcacg ccgctcgcac
     5101 cggtgctcgg cgcgttcctc gccgacctcg cgggtggagc gctcgcgctg ctcgtgttcg
     5161 gcgcgctgat cctggtcacg gccctggtgg cggcgttcac ggatctccgg gcgccagctc
     5221 cgcaacagtc ctgaggtggt cgttgcgctg ccggatgagc tcggccatgt accggtcgag
     5281 cacgagacgt tcagcgaggc gcccgagcgg accgagtggc gcggcgaact cgacgacgtc
     5341 ccgcatgcgc gtgccgcccc gcccgtccgg ctcgaagtga tgagcgtggt gccagcgccg
     5401 gaacggaccc gcgacctgct cgtcgacgaa gtggtgcggc cggtcgagtg ccgtgatgca
     5461 cgaggtcatc cgccagcgca caccgaagtg accggcctgc cacgtcacgg tgtcacccgg
     5521 ccccatccgg ccggagctga tgccaccgac gatccgctca ccggagccgg ccatcgaggc
     5581 ggtgtgcacg tcgacgtcga ggctgagatc gaacacgcgg tgcggcgggg ccgcgatacc
     5641 ggtgatcacc tcgaagcggg tcgtgcctcg aacgctacga ccggcgacct gagagctgcc
     5701 ggtcgacgat ctcggcgagc cgggacagtc caccggcacg ctccatgctc gcggcgatcc
     5761 gccgcgcgcg tacccggtag cgcggatcgc cgagcaccgc gcgaaccgcc cgcccgacgg
     5821 cagcaggcga gggcgtctcg gtcctgagcg cacgaccgac accggaccac acaactcggc
     5881 cggcgacctc cggcttgtcc tctttaccgc cactcgtgac gatcgggacg ccgtggcgga
     5941 gggcgtactg gacgccaccg tagccaccgt tggtgacgta gacctgcgtt ttcggcagga
     6001 gttcgtcgta gggaaggtac tcagcggcac gagcgttcga cggcaacggc ggaagggtgg
     6061 agagcggccg gcccccggtg gacacgacga cgaggacgtc atcatcggcg agagccgcga
     6121 ggctgggttc gatgatctgc cggtagtcgt ggttggcgac cgtgccctgc gtgacgtgga
     6181 cgaccggccg cgagccgtcg agctcgtccc accaggacgg caacggcgcc tgcgaaccgg
     6241 aggccgagat ggggccggcg aagtgcaggg tggcgggtgc gtcggagcgc gggtactcga
     6301 actcgggcac ggtgaactgc acgatcgcct cggcgtgccg gagccagtcc atgatcggga
     6361 acggcagcgg ggacccgttc agctcgtggt tgatctcctg ggccagccgc tcggccgcgg
     6421 tgaagaccgt gcgcgcggcg atgttggtga gcagggcgtt gcgcaggcga ccgagaggtc
     6481 cgcgcagcgg cgtcaggccc atgccgtacg gcgcggtgtc acggctggag atcgggagcg
     6541 ggagcacacc gcacacgacc accggtggcc gctcgccgag cggccggcag acgaggaacg
     6601 cgccgccgag gaacgccggc tcggtgatca cgacgtcggc cggctcggcc gactgcgccg
     6661 cctcgatcac cttgtaatgg gcgcgaccgg ggcgcacgaa gacgttctcc aggtcgaacg
     6721 cgatcgcctt cgcccccttg agcgctgtgc gctcggggaa cgtcaccccg aagtcctgcc
     6781 ggtcgtcgaa gtcggcttcc gcgggcagtg cgatgtgctc cgcacccgcg gcctccacca
     6841 cctcggcgaa acgggagcca gtgatgaacc ggacgcgatc tccccgctgg gtgaagtagc
     6901 gggctacggc cagaagtggc gtgacatgcc cgtggacggg caccgtcgcg atgatgaggg
     6961 acgccatgac gtcacccgcc taggacattg ggagcagtgt tgaagactgt catgcagtat
     7021 taacctgcat gggaacgtag tcaataatgt cggacatgac cgaatcaacc cgcccctacc
     7081 gctccgagct gcgacggcgg caggcggcgg aaacgcggcg aagagtggtc gaagcggcgg
     7141 cggagctctt cagccggcag ggctaccagg ccacgacgtt cgcccagctc gccaccgcgg
     7201 cgggcgtgtc cgtcgagacc gtgcagcgcc acggccccaa gtcggcgctg ctgcaggccg
     7261 cgctggagct cgtgtccttc ggggtcgagg gtgagaccga cctgctcgcc accgacttgg
     7321 gaaaggccat gctgcaggtg agcggcaccg ctgagctcgc cgccctgatc ggggacgcga
     7381 tgctcgcgat caacgctccg tcggcaggcc tctgggtggc ggtcgccagc gcggcgcagg
     7441 gcgacgagga gcttcgcggg tattacgccg ccaacctcgc cctgctgcga cggcaggtcg
     7501 aacacgtctt ccacgtcttc gccgaacgcg gctggctgcg cgcggacgtg cccttcgacg
     7561 acctcgtcga agccttctgc gtgatcacca gcgtcgaggc gtacgtgcgg ttcgtccggc
     7621 tggacggcaa accggacgac acctacgcgg cgttcgtggc gcgcacggtg ggagaaacga
     7681 ttctcagccc tcctctgcga tcatctcccg catccgggtg agcgcacggt gctgtgccac
     7741 ccgcaccgca cccggcgtcg actccacggc cagcgcgacc tcctccgcgg acagccccac
     7801 cgccacgcgc agcaccagga tctcgcgctg acgtgccggc agcttgtgca gcaggcgcgt
     7861 gacctgggcc atcatctcgc cgttgaccgc gtgctgctcc gggccgtcgt cgagcgacgg
     7921 gcagtcgggc agctccggca cgacctcggc gcggttgcgg acggcgcggc gacgggcgtc
     7981 ggcgaccttg tgggcggcga tgccgtagac gaacgcgagg aacgactgcg gctcgtagcg
     8041 gtacttggac agggcaccga gcaccgcgac gcagacctcc tgcgcgatgt cctcggccga
     8101 gacgagggtg cgctcacggc caccaaccct ggcgcggcag tacctcacga tcaacggctg
     8161 gatccggccg agcaggtgct cgaccgcccg tctgtctccg tccagagcgg cgtcgacgag
     8221 gtcggtgaac tcggcttcgg cgagccactg gttggagacc ggtgcctggc gcacccgacg
     8281 acgcatgggc accgttggct ggttccacac ctcctctgga tcgaggacgc cgacaccgcc
     8341 accggtccgc acggctgtgg gttggaccat cccggcgacc tcctccacta cagcgacact
     8401 aggggcttca cagaagaaga gaccgcagcg agccgtctga taccgcctgt ctccaagagg
     8461 accacgaagt ccaggcgggt ggggcaagca gcaccctttt ggggtagaag gtggtcctaa
     8521 cggcccagtc tttcggccat tgcgaattgc tgaattccga ggtagccgac ccggaaccgg
     8581 cctccgagcg ggccgggtga aactcccgca tccggcggaa cgcgtcgtcg aagccgagct
     8641 gtgtcacctc gtccgaacgg gtgaggaagg tgtgccgcca ccgcttcggg gtctcggctc
     8701 agtcgtgccc gaatgaccac gtcccggcgg tccgtggtcg cgcaccgaga agtacgccgg
     8761 ccggtattcg gcactgactg cctcgatcac cgaggcgatg acgacggcgt cgtactgacc
     8821 gtgctcctct cggtagtcgc cgtcacccga tcgtggagac ccgcgcacct cgcccggtcc
     8881 agcgcggctc gccggttgag cgtcaggtca cgccggtact gttcgaactc gtgatcgacc
     8941 acctgagcat cgagaccgag gcaggcacct tcgacgccat cgcgtccggt ccagaggacg
     9001 gccgcccggt cctgctgctg cacggcttcc ccgaggccgc catcgagtgg gagcaccagg
     9061 tagcggtgct cggcgcgaac ggcttccgcg ccgtcgcccc cgaccagcgc ggctactccc
     9121 ccggagtccg cccggagcag tcctccgagt acacggtcac gcacctcgtc ggcgacgtga
     9181 tcgcgatggc cgacgcgcag ggctggtcca ccttcgacct cgtcgggcac gactggggtg
     9241 gcgctgtcgc gtggtggacg gcgatcgacc acccggaccg tctccgcacc ttgagcgtgt
     9301 tctccacacc gcaccccggc gcgctgaaga ccgcgctgcg gaccgacgaa gagcagcgga
     9361 tgcggtccca gtacatgctc gactggcgcg aacgcagcac cgagcgccgc atgctggaga
     9421 acaacgcgca cgccctgcgg cagatgttcg agtaccggat ccggccgtcg cacgtggacg
     9481 agtacatcca gcgcctgtcc gagccgggcg cgctctcggc cgccttgaac tggtaccgcg
     9541 cgggcaagcc gtccggcgcc gcagacaagg tggccgtcaa gacgatgtac gtctggagca
     9601 ccgaggacgt cgcgttcgga tcggtggccg cgttcgagac cgagaagtgg tgcaccgggc
     9661 cctaccggtt cgagatggtc gaggacgtga gccactggat tcccgaggag atcccggagg
     9721 cggcgagctc ccttctcctc gaacacctct cctaaacctg gttttccggt tgcggcagtt
     9781 gccggaaccg gaagccgttc tgcctggtcg ccggtccagc cctctcgtta cgttcgattc
     9841 agcgcgctgc catgaagatc cctcaacgag agaggcagaa ccatgtacga gacgccgcag
     9901 ctgatcgacc tgggcacctt cgaagcgcag acgggcctgc tccagaggaa cggcaacgac
     9961 cggctgatct tcagcaagaa ctgacgcgac accaccgcga atgcctgatc aggcctcgcg
    10021 gggtcacggc gagtcgcact tcgtggtcct acccgaccac gaagccgcgc tcgccgtggc
    10081 ccgtcgcttg tgtgcgccgg ggttccgatc gctgcagcac gcgtcgggac gtccgtggct
    10141 cgccggccgg tggcgcgacg acgagatcgt cgccgcggca gcgggtgacg cccggctggc
    10201 ggtgatcggc tggtgcccgg tcagcgtcgc ggaactggaa cgcgcggccg ccggcctgcg
    10261 cgacctcacc cacctcgacg agctcgcccg caggctgccg ggcagcttcc acctcgtcgc
    10321 gtcgctcggc gggcggtgcc gcgtccaggg cacggcgtcc gggctgcggc tggtgttcca
    10381 ccgccggatc ggcgaggtcg tggtcgcggc cgaccgtgcg gacctgctgg cccaggactc
    10441 ccctgtggac gaacggggcc tggtcgtgcg actgctcttc cccacgccgc acccgttgct
    10501 ggaacggacg atgtggcgcg atgtggaatg tgtaccgccc ggcagcgcgt tgctggtcga
    10561 cggcggccgc gcccggttga cccggtggtg gcgcgacccg gaaccggtgc gcggcatcgc
    10621 ggagtccgtc ccgttgatca gggacgccct cgccaccgcg gtcgacgtcc gcacgcgagc
    10681 aggcggcacc gtcgcgtgcg atctctccgg tgggctggac tccacgtcga tcacgttcct
    10741 cgcggccagg tcggacgcgc ggatcgtggc cagcacctgg cccgcgctgg acccggtgga
    10801 cgaggacgtg gcctgggcac ggcgagccgc ggcgcacctg ccgatggtcg agcacgtcgt
    10861 gtggccggcc gaacgcatcc cgctggtgta cgagaacctg ctcggcatcg acgacccgat
    10921 ggacgagccc accatcggga tgatggaccg ccagcgcctg ctggaggacc tgaaaggctt
    10981 ggcggagaag ggaagccggg tccggctgac cggcatcggc ggagatcacg tcgcctggtg
    11041 ctccgaagcg cactaccacc cgttgctgcg caggcggccg ttgttcgcga tccggcagct
    11101 gcgcgcgttc cgggcgctgt tcgactggcc gctgaagccg atgatctcag cgctcgcgga
    11161 ctcccgctcg tacggtgcgt ggctcgcgga cgaggctgag cgactgcgag cgccgcgcga
    11221 cccgaacgtc atcggcacac tcggctgggg caccggaccg aggttgttcg actgggtgac
    11281 gcccgaggca caggcgctcg cccgcgacac gctgctggac gccgccgcga cagcggaacc
    11341 gttggggcgc aacagaggcg agcacggcga cctggagccg atcctgtcct gctcgcgcat
    11401 catccggcag tgggagcaga tgagtgcgcg ggcgggactg ccgatccagt caccgttcct
    11461 ggacgaccgc gtgatcgagg cgtgcctgtc ggtgcggccg gaggaacgcg tgacgccgtg
    11521 gcgctacaag cccgtgctca ccgaggcgat gcgcgggatc gtgccggacg agtgcctggc
    11581 gcggacgaac aaggcgcagg cggcgctgga ggcctcggcc ggcctgcgca ggcaccgcgg
    11641 tgacctgctg gagctgtggg agagctcgaa gctcgccgac ctgggcctgg tcgaccgccg
    11701 caggctgacc gagctcgcgt tgcggccgga cacgccagag ctccgcaccg ggatcttgta
    11761 ctcgacgatc ggctgcgagg tgtggttgcg cagcctggac aagggagcag aacatgcggt
    11821 tgcgggctga cgtttccgtg gcggacaccg actacggcca ggtgctgctc gacgagcgca
    11881 gcggccggta ctggcagctc aacccgaccg gcgtggccgt ggtgcgggcg ttgctcgagg
    11941 gggccgacga gaacgcggcc gtcgcggcgc tcacctccgc gtacgaggtg gacgaggcac
    12001 gggcgcggca ggacgtgtcg gccctggtgg cggggctgcg gaccgcgggc ctggtgacga
    12061 cgtgaccaca ccctcgtcac tcagccgccc caccggcgtc ccgctccgcc gccgcatcgc
    12121 ggcccgcctg gcggtcacgg ccgccacccc gctggcccac ctcaagccgc gcaccctgcg
    12181 ccggatcctg agcctcctcc gccgaggcgc caaacccgcc ccctacgaca ccgccaaagc
    12241 ggcacgggac gccgtgctgg cggtgagcct gcggtgcctc ggcccgcagg gttgcctgcc
    12301 gaggtccgtc gccgtggcac tgctgtgccg gatgtcgggc acgtggccga cgtggtgtgc
    12361 cggcgtgcgc gtgatgccgc cgttcggggc gcacgcctgg gtcgaggcgg acggcgtgcc
    12421 cgtcgacgag aacctgcccg ctcagtactt ccgtcccctg atgacggtat gaggacgctc
    12481 gacctgctgc ggctggcctc cgggcacggg cgcggtctcg cactggccgt gacggcgacg
    12541 ctggtcgcgg ccggactcgg actgctccag ccccagttgc tgcgtgccgc cgtcgactcg
    12601 gccacgtcgg tgccgtggca gctgctcgcg gcgatggccg tgttgttcct cgcgcaggcg
    12661 tgtgtcgacg gtgcggggct gtacctgttg gaacgcaccg gggaacgtgt cgtgctcggg
    12721 gtgcggcgca ggctggtggc ccggttgttg cggctgcgga tgaaggcgtt cgacgagcac
    12781 cgggtgggcg acctgatgtc gcgggtcagc gtcgacacga cggtgttgcg cgaggtcgtc
    12841 tccaccgcgt cggtccagct gatcaccggc acgctcacgg gcgtcggcac cgtggtgctg
    12901 atggtgctga tcgacccggt gttgttcctg tgggtgggca cgaccgtcgt ggtcgccgcc
    12961 gtggtcgtct actcgctggt cggcaggctt cgtgccgccg gtgagcagat gcaacgcggc
    13021 gtcggtgaca tgaccgcgga actggagcgc gcgctcgggg cgttgcgcac cgtgcgcgcg
    13081 tgccgggcgg aggaacgcga agaggagctg atcgggcgac gtgccgagca ggcgtgcgcg
    13141 gccggggtgc gggccgcgcg gatcacgtcg gtgatgagcc ccgccgtcga actggcgatg
    13201 cgcgggtcgc tgctcgtggt gctgctcgtc ggcggcacgc gggtcgcgag ggacgcggcg
    13261 tcggtcggcg acctgatggc gttcctgctc tacgcgacct acctgatcat ccccttcacc
    13321 tcggtgctgc agggcatcgg gctgctgcag aagggcatgg gcgcgctcgg cagggtcgcc
    13381 gaggtgcagg agctgccggt cgagggcacc gcgggcggcg tggtgcccga gtgtgcgggg
    13441 atcaggctgg agttccgcga cgtctggttc cgctaccggg accgcccggt gctgcgcggt
    13501 gtctcgttca ccgtcgagcc gcggtcgcac gtcgcgctgg tcgggctgtc cggtgccggc
    13561 aagtcgaccc tgttttcgct gatcgagcgg ttctacgaac ccgattccgg agctctgctc
    13621 gcaaacggga tcgacattcg gaacttttcc cgtgaccaat ggcgtgcacg aattgcgctg
    13681 gtcgatcagg actcgacagt tctcaacggc acactccgtg acaatctcag ttacgcagcg
    13741 ccgcattcgt ccgatcacga tcttcacgaa gtactggaac tcgcgaatct caccgaactc
    13801 gtcgagcggc ttccggacgg actggacaca ccattgggtg aacgcggacg agcgttgtcc
    13861 ggcggggaac gtcagcgcat cgcactggcc agggctctgc tgacccagcc tgacctgctc
    13921 cttctcgacg agcccaccgc ccatctcgac ccggtgaacg aacgggcgct gcaccgcgcg
    13981 attcaccagg ccgcacagga gtgcgcattg ctggtgatcg cacaccggct gtcgacaatt
    14041 cgcgaagcca accggatcgt ggtattgcgc gcaggcgaag tcattgccca gggcacgcac
    14101 gacgagttgc tcgggatcaa cggtttctac agcgggctgg cggggggcag attcgttgac
    14161 aattctaagt tgttcgagac cgaaatatcc cctggatgga ggtaggacgt tcgacgccgt
    14221 cgatgcgaac atgactgagc cgtcagcatt cgaaaggaag gcgaagtcgt gttgcagcga
    14281 tctccatcag gccgcaccga attcgtcgag gtccttcacg accgctcttc ggtgatgcgc
    14341 acgctcgacc acctcgtgac caggtccgcg gcggtcagag cggtgctgtc gagccgcggc
    14401 ggcatcgaca gcgccctgct cggcctcatg agcaacgccg ccgaccgagg ccgcctgctg
    14461 ctcgacccac cgctcgccag gcacaccgag acgatcgggc gcgtggcacg gcaccacgtg
    14521 gacatccggg tgcacaccca gccggcgcgt cacatgctgg tcttcgacga cagggccgcc
    14581 gtcctgccgc tcgacgcgag cgacctcaac accggcgccg tgctgctgcg ctgcccgctc
    14641 tccactccgt acggccagct gttcgagctg atgtggtcgg atgcggagac tctctccgag
    14701 aacgctccgc cgcccgacgg cctgaccagc cgtgaagccg aagtcatcgg acttctgctg
    14761 aacggggcga cagatcacca ggtcgccgcc cgactcggca tgagcagccg cactgtgcgc
    14821 gcagtggtag cccatctgca acagcgcttc gggacacgat cacgcatggc gctcggcttc
    14881 cagatcgcca gatcgacgaa ttaggtctag acatcggagt tctgaccaag ttaggtcgtg
    14941 ggtgccgccg cctcggcacg ccccttggag ggaacaccat gaccacgtcc aggcgcgact
    15001 tcgtcagact cggcggcgcc gcactagccg gtggcgtcgc tctgggaacc ggtacggcgt
    15061 cggcgaaaga gcgcatcgac tggtcggtcg aggtcgtcga gtcgaccatg cggcagttca
    15121 cgccggagac gctcggcggc tggggctaca cgcgcgggct ctacctctgg gggcagtggc
    15181 tcgtcttcca gcgcacgaag aacaagaagt acttcgacta cgtcaaggcg tgggtggacc
    15241 gcttcgtcgg tccggacggg aagttcaacc ggacgttcac ccacctcgac tcgatgcgcg
    15301 cgggccagct gttgccgttg ctctacaacg cgaccgggga cgtgcggtac cgcgtcgcct
    15361 cgacgcagat ccgcgagcgt ctgaacacct actcgcgcac caaggaaggc ggcttctggc
    15421 acgccgaggg cggcacgcgc gactggcaga actggtcgga cggcgtctac atggtcgtgc
    15481 cgttcatcat gcggcacggg tacacgttcg gggagaagga ctgggcgacc gccgaggcgt
    15541 tgcggcagct cctcgtctac gcgaagaacc tgcagcacaa ggacggtctc ttccaccacg
    15601 cgtacgacga gtcgcgcacg gcctcgtggg cgaatccggc gacgggcgtg tcgccggagt
    15661 tctggggcag ggcgatgggc tggtacgcga tcacgtgctg cgacgtgctg gaggacctgc
    15721 cgcgcaccca ccccgaccgg ccgaagctga tctcgatcct cggcaggctg atcgcggcac
    15781 tcgcacgcca ccaggacccg aagtccgggc gctggttcca ggtcgtggac aagggctcga
    15841 acccgcggaa ctggaccgag acctcgtgct cgtcgatgta ctcgatggcg atctcacgtg
    15901 ccgtcgagcg cggatatgtg tcgcgcaggt acgaggtcgt ggcgcagcgc ggctatcgcg
    15961 gggtgctgga acgcgtgtcg atcaacgcac agggctccac cgagatctcc gagatctgca
    16021 tcggcacgaa cgtcggtgac ctgccgttct acctcgcccg gccgagagcc gtgaacgacc
    16081 tgcacggcat cggggcgttc ctcatcatga gcgagcagtt ccaaaggagg taggttcgga
    16141 ggcatgcgcg tggccggcct cctgctagct gcgggggccg gccgccggtt cggctccccc
    16201 aaagctcttg tctcgttgca cggcaagctt tttgtcgact cggcggctga gctgttacgc
    16261 gctgccgggt gcgagccggt cgtcgtcgtc ctcggcgcca tggcggacga ggtgcgggca
    16321 aaggcctctt tggacggcgt gaccgtcgtc gacaacccgg actgggagtc cggcatgggc
    16381 tcgtcgctgc gaacgggcct gcacgcggcc ggcatcgtcg acgccgttgt ggtgcttccc
    16441 gtggacacac ccggcgtcac cgtcgccgcc ctgcaccgcc tgatggaact cgccgagccg
    16501 aaagcgttgg cacgcgcggt ctacgacggc aaggtcggac acccggtcct gatcggctcc
    16561 gaccacttcg cgggcgtgat ggcgtcggca gcgggcgacc agggcgcgcg ggactacctc
    16621 aaagccaaca ccgtccgcca cgtcgaatgc gctgacgtgg cggacggtgc tgacgttgat
    16681 cgaccggaag acctcaggcc acgtaacggc gaagcttgat gcccgacgac acgttggacg
    16741 cgctcagcca gtggagccgg ccgcccgcgt aggccggatc ggccacggcg aactcgttgc
    16801 caccggcgcg gtagccgacg accgtggcgt agtggccgcc ggagtagttg cggccgttca
    16861 ggcggatcac gttgatcacg acggcgtggc cgcggctggc gttgtagacg acgtcggcct
    16921 tgagcttctg cagcagctgc gcgtcggtcg accactgctt gacctggtag taagtggagc
    16981 cggtgtagtg gtcgagggcg ctctcgaggt tcttgatgtt cggcaggccg ttggtcgtga
    17041 ccttcatgta cgaggccaga gtggactgtt cgacctcctt gcaccgcgcg gtcagcgcga
    17101 tgcgggcggc ggcagcggaa caccagtagc cggtcttctg cacctggaac tcgtgcggca
    17161 gaacaccttc accctggatg ccgagctctg cggcggccgg gatgacggtc tcgcccggcg
    17221 cggccagcgc gaccggcgcg gtgaagatgg tcatcgccac gccgacggcg gcgacagccc
    17281 cggtgatcct cgcaagcttc atctctcgtt ccccccagtg gtggcgccga acccctggcg
    17341 cggcgctcgg cgaaagcttg ctggcagccc gcgaacactc gccaccagat tcggccaagt
    17401 ccgaaaaagc caggtagaag cactcagccg gtacaagccc tgcggcgctg tgccactctg
    17461 cttgccgtgt tgcgtgtcca cttcccggcg gaggacctgg cgagggtgcg cgtcgcccct
    17521 ggtcccgacc cgatgtggga gatcctgctg agcctgcacg tgctgcggca gcgttcggcg
    17581 accccggtgt tcggcacgtg gcgcgcgaac gtgcgatcga ccctgcccga cgacgcgcgc
    17641 tggctcatgc agctggcgcc gcccgtcggc tactccccga cttcctgacg cccaccgcgg
    17701 gctcctgcgc actcgacgcg ggcatcgacg ccgtcctggc gacgcccgtg gagtcgttgc
    17761 gcgccgacct cgcgcaactg ggccgccggc aacgactcga cccgcgcacc aacctgctgg
    17821 ccagcggcga cgtggccact ttgggctcac tcggcgaggc gttgcgcgcc taccaccgcc
    17881 acgcgctggc cccgatctgg gacgagatcc gcgccgtcgt cgacgcggac cgcgcggtgc
    17941 gggcgaggtc ctttctggac ggtgactgcg agggcatgct ctcggccatc tcgtggtccc
    18001 cgcccgtact gtcgatcgag tcccgcttcc cgcagcgcga cgtccacctg cacggccaag
    18061 gcctcgtact ggtcccgtcc cacttctgct gggaacgccc gatcatgctc cgcgaccagc
    18121 gccacccgcc ggtcctcgtc tacccgatcg cccgcgacct ccacatcacg accaacggca
    18181 aacgctcact ggaggcgctc ctgggccgca cccgcgcggc ggcgctgggg gtcatcgccg
    18241 gcggctgcac gaccacagag ctcgcccgcc gcctgggcct ctccgccgcg tcggccagcg
    18301 cccacgcctc ggtcctgcgc gacgcgggcc tggccgtggc ccagcggcac cgcaactccg
    18361 tcctgcacac ggcctcagcg ctgggcgtgg aactcctcgc ccagcgccgc cgctccccac
    18421 ccggtcggat cctcaccttc cggcaccatc gccagggcgt gccaccgcag aagcacctcc
    18481 caccagccgg cctcgacctc ggtcaaccgg cgcacggact catggcctgc gaggaacgcc
    18541 gcgtgcacct cggccggcac cggcccccag tcgcggaagc gggtcccgag caggaccgcc
    18601 gaccgcgcca gctcgacgac ccggtggtcg agcgcgatct cctcgaagtc gaggatcgcg
    18661 gcaacctcgc ccccggccca caggacgttg gcggaccgga agtcgcgatg aacgagctgc
    18721 gcccgcagcc gcccggcagg cacaccgccg agcatcgagc gcaaggcctc ccgcgccgtc
    18781 ccgggcaggt gcccggcgct ggagtcgagc cagccggtga cccgagccgt caggggcagc
    18841 ggcggaccgc cgaacgcggc aacccgatca ccgtcgggat acgccgccaa cgcgtcctgc
    18901 aaccgggcca gcaccgcccc ggcctcacgc acctggcctg catcggtgac gtcgagcagc
    18961 tcaccctcga cctcatgctg caatcccatc gaggcaccgg ccacctcgac ctgcagacgc
    19021 ccgtccaacg cgggaaccgg taccgaaacc gggatccccc ggccgtccag ccaccgcgtg
    19081 agccgcgcga cctccaccag ccgcgcaaac agctccggca ccaccgacca cttcgcgatc
    19141 atccgccctt ccggcgtacc gacccacgcc aaggcgttgt ggtcgctgat gacgatccgc
    19201 tcgcacgaaa gaacccgaac accccagtgc tcgcccagcg cggtggcgac ccagcgccca
    19261 gccgcccgct cgtctccgaa gccgaatctg cccccaagcg caccgagcgg atcgtgcgct
    19321 tcccacaaca tctccaccac cggcgcatgc gattcagcca tgcacccatg acacacgaaa
    19381 cctaaggccg cgtgcgcacc gccgcccgcg cacacccacc ggcgacgacg agctgcgcca
    19441 tcgccaccca caccggccac aacacggagt aggtgatcgc gagcgctatg tgcgtggccc
    19501 ccgcggtcgt gaagaccgcc gccagcacaa cccagatgta gaagtaccgc ctgatcaaac
    19561 ccacctccgc ccgccaagag tgaccgcacc tgtcatcgcg cgtatcgagg tttgtggtgc
    19621 tcgggttact ggtgagccca cggcacttcc ggtactactg acccgcatga cgaccgacac
    19681 cgtgaccggc tccgactacg gcaacctcgt gcgcacgcac ctgacacgcg tcgaacagca
    19741 caacgcggca gcgctcgacg acgtggccga gctcgtgctg gccgccgtac aggcggacgg
    19801 catgatcctc accgcgggcg ccggccactc cctggcggcg gtcgccgaaa ccttctaccg
    19861 ggcaggcggc ctggcctgcg tccgcccgat ctaccacccg gaactgctcc cgatgcacgg
    19921 cgccatcagc agcaccgcgg ccgaacgccg ctcgggcctg gcgggcgagg tcctccgcga
    19981 agcgggcctg gccccgcacg acgtcctctt cgtcttctcc acctcgggcg tcaaccacta
    20041 cccggtggaa ctggcccagg aggccgccgg ggcaggctgc ccggtagtcg ccgtcacctc
    20101 ggtcaccgcc agcgcccagg ccccccgccg cgccggcgcc accctcgccg aggtggccac
    20161 cgtcgtcctg gacaacctcg tcccgcccgg cgactccacc tacccggaac aggccccggt
    20221 caccgccgcc gtctccaccc tcgccaccac gttcctctgg aacctgctga tggtccgcct
    20281 ggtcgacaag gccaccgaaa ccggcgtgca actgccgctg tggcgcagcg ccaacgtgga
    20341 aggaggcgac gcggccaacg ccgacctgct caggcactac caaacccgca tcccgcagct
    20401 gggttgagta gcaatactca gcagcttttc agcgtcttcg cgttagtctc ccaccgggga
    20461 aagcacttac ctggggggac ttcaccagtg gagccgaaaa cacgtagatg gatcctgatc
    20521 ggcggcgcgc tcgccacagc caccacgatc ggtgtggcgg gcgcactgct ctggagcccg
    20581 gatccggtca tctcggaaaa gccgaagaac caggcgaacc agtcggtcga acgaccggcc
    20641 gacgtagccc tgtcgttcgt gaacaagctg tccagctccg acgccgccgc agcagcccag
    20701 ctgaccgacg caccggacgc cgccgccaag gcgatcgccg ccaccagaac gggcatggcc
    20761 gcctccgcct accaagcccg cctggccgcg acaacaccac cggcccccga cgccaccaca
    20821 acggacctaa cggcctccgt gacgtggacg atgccgagct ccgccgtgct gaagtacgac
    20881 gtcaaactca ccgtgcagaa gtccggcgaa gcctggaagg tccactggac gccgacgctg
    20941 ctccacccgc aactgaccga gggcagctcc ctcgtctacc gcgcggccct cgctgacggc
    21001 gccctcctgg gccgcgacgg caaaccactg gtcaagggca ccatcccaga cggcctctac
    21061 aacacgatca ccggccagac cggcgatctc aaaggcaccg acggctggga agtgggcatc
    21121 tcctccaccg caggcttcac caagctggac ggcaaggccc cagaaggcgg ccaaaagatc
    21181 acagtgacga tcgacccggc ccgccaagca gcagcccaag ccgcagtgga cgccctcccg
    21241 cagggcgcgg ccatcgtggc gatcgagccc tcaaccagcg agatcctggc cgtggcccaa
    21301 aacaaaaccc tgtccggcac aaacccgttc gtaggccgct acgccccggg ctcaacgatg
    21361 aaaatcgtga ccgcagccgc cgccatgaac gcaggcctcg tccaagccaa caccgcagtc
    21421 ccgtgcccgg ccaccgccac catcggcacc cgccgcatca gcaacgcggg cttcggccac
    21481 gactccctgc ccttccacac ggccttcgcc ctctcctgca acacgaccat gggggaactg
    21541 ggcgcaaaac tcccaccgaa cgccctcccg gacatggcca agcgcttcgg cctgggcgcc
    21601 gactggacca tcacgggcgc cgacacgaac accggcaaag tccccccggc ctccggcgac
    21661 cagcaggtgg aaaacagctt cggccagggc aacgtggtag ccagcccgtt cggcatggcc
    21721 ctggtagcgg caaccgtggt ctccggcaag acccccacgc ccaccctcat gcgaggcaag
    21781 ccgccgacac ccaacgacgt ggccgccgcc ccaccagccg caaccctcca gcctctccgc
    21841 aacatgatgc gagaggtggt aaccacggga acggccaaac aactctccgg catcccgggc
    21901 ctggcgggca aaaccggcac cgcagaagca ggcggcggca cagcccacgg ctggttcgtg
    21961 ggctaccagg gcaacatggc cttcgcggtg ttcgtagaga acgcaggctc gtcccaaagc
    22021 gccctaaccg ccacagccgc attcctgaag cgctgacggc aacagcgagc ccaagcgaag
    22081 ccgaaggcga gcaaaggcga cggcgaaagg cgagctgcta tccacaacgc aggccgccgt
    22141 gggatgggcc ccgtcacgca ccgccgcaag cacctacgca acagcaagcc gcccgcccaa
    22201 agcaacaggc gtgccatcta cctgcgcgtg gcgctggcgg gtctttgatc agattggcgg
    22261 ggtccggggc ggagccccgg gaaaccctcg caaccgccgc gtccgatgcc aacgcgccca
    22321 cctacggatc ccaaaagatc agtacctctg cccaacctca gccgaagaaa acttcacagt
    22381 cggataaaca gcaacagcag gcggctcaga gaactgagtc cgataaagat ccgaataccg
    22441 cccctcagcg gccatcaact ccgaatgcgt cc
//
