GCF_003268475.1 - 12 region(s)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	RRE-containing	136,005	156,742
Region 2.2	betalactone	263,026	293,688
Region 2.3	azole-containing-RiPP	396,879	429,485
Region 2.4	NRPS-like,NRPS	1,381,384	1,435,666	High	icosalide A/icosalide B	NRPS:Type I
Region 2.5	terpene-precursor	1,498,247	1,519,374
Region 2.6	ranthipeptide	1,722,757	1,744,418
Region 2.7	redox-cofactor,lanthipeptide-class-ii	2,088,356	2,118,942
Region 2.8	azole-containing-RiPP,RRE-containing	2,514,679	2,547,399
Region 2.9	betalactone	4,538,462	4,564,027
Region 2.10	terpene	4,647,904	4,668,866
Region 2.11	terpene	4,863,532	4,884,287
Region 2.12	terpene-precursor	5,573,851	5,594,894

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	RRE-containing	136,005	156,742
Region 2.2	betalactone	263,026	293,688
Region 2.3	azole-containing-RiPP	396,879	429,485
Region 2.4	NRPS-like,NRPS	1,381,384	1,435,666	High	icosalide A/icosalide B	NRPS:Type I
Region 2.5	terpene-precursor	1,498,247	1,519,374
Region 2.6	ranthipeptide	1,722,757	1,744,418
Region 2.7	redox-cofactor,lanthipeptide-class-ii	2,088,356	2,118,942
Region 2.8	azole-containing-RiPP,RRE-containing	2,514,679	2,547,399
Region 2.9	betalactone	4,538,462	4,564,027
Region 2.10	terpene	4,647,904	4,668,866
Region 2.11	terpene	4,863,532	4,884,287
Region 2.12	terpene-precursor	5,573,851	5,594,894

NZ_MCIF01000002.1 - Region 1 - RRE-containing

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Location: 136,005 - 156,742 nt. (total: 20,738 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001779.5	0.41	ribosomal	siamycin	Streptomyces nodosus
BGC0001210.5	0.41	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000616.4	0.41	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000626.3	0.40	ribosomal	thuricin	Bacillus thuringiensis
BGC0000521.3	0.40	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001743.3	0.40	ribosomal	plantaricyclin	Lactobacillus plantarum
BGC0000539.5	0.40	ribosomal	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001779.5	0.41	ribosomal	siamycin	Streptomyces nodosus
BGC0001210.5	0.41	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000616.4	0.41	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000626.3	0.40	ribosomal	thuricin	Bacillus thuringiensis
BGC0000521.3	0.40	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001743.3	0.40	ribosomal	plantaricyclin	Lactobacillus plantarum
BGC0000539.5	0.40	ribosomal	nukacin ISK-1	Staphylococcus warneri

Regulator	Description
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_MCIF01000002.1 - Region 2 - betalactone

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Location: 263,026 - 293,688 nt. (total: 30,663 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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additional biosynthetic genes

transport-related genes

regulatory genes

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000597.4	0.45	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000131.5	0.44	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001137.5	0.44	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000923.3	0.42	other (other)	paerucumarin	Pseudomonas aeruginosa PAO1
BGC0002128.3	0.42	other (other)	5-dimethylallylindole-3-acetonitrile	Streptomyces coelicolor A3(2)
BGC0001778.5	0.42	other (other)	showdomycin	Streptomyces showdoensis
BGC0000922.5	0.42	PKS	2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one	Pseudomonas aeruginosa PAO1
BGC0000595.3	0.42	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001343.3	0.42	PKS	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000597.4	0.45	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000131.5	0.44	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0001137.5	0.44	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000923.3	0.42	other (other)	paerucumarin	Pseudomonas aeruginosa PAO1
BGC0002128.3	0.42	other (other)	5-dimethylallylindole-3-acetonitrile	Streptomyces coelicolor A3(2)
BGC0001778.5	0.42	other (other)	showdomycin	Streptomyces showdoensis
BGC0000922.5	0.42	PKS	2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one	Pseudomonas aeruginosa PAO1
BGC0000595.3	0.42	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001343.3	0.42	PKS	aurachin A, aurachin D	Stigmatella aurantiaca Sg a15
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102

NZ_MCIF01000002.1 - Region 3 - azole-containing-RiPP

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Location: 396,879 - 429,485 nt. (total: 32,607 nt) Show pHMM detection rules used

Legend:

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001145.5	0.57	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001146.5	0.56	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000603.5	0.56	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000613.5	0.53	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001860.4	0.53	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000605.5	0.53	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0002311.3	0.52	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0000607.5	0.52	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001640.3	0.52	ribosomal	kocurin	Kocuria rosea
BGC0002120.3	0.49	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001145.5	0.57	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001146.5	0.56	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000603.5	0.56	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000613.5	0.53	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0001860.4	0.53	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000605.5	0.53	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0002311.3	0.52	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0000607.5	0.52	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001640.3	0.52	ribosomal	kocurin	Kocuria rosea
BGC0002120.3	0.49	ribosomal	nocathioamide A	Nocardia terpenica IFM 0706

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_MCIF01000002.1 - Region 4 - NRPS,NRPS-like

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Location: 1,381,384 - 1,435,666 nt. (total: 54,283 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.88	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001249.5	0.84	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.78	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.76	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.69	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.69	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Regulator	Description
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism
RutR	Regulator of the pyrimidine and purine metabolism

NZ_MCIF01000002.1 - Region 5 - terpene-precursor

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Location: 1,498,247 - 1,519,374 nt. (total: 21,128 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002405.2	0.46	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000597.4	0.38	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000664.5	0.37	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000595.3	0.37	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001911.3	0.37	terpene	raimonol	Streptomyces anulatus
BGC0001529.5	0.37	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000678.5	0.36	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002405.2	0.46	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000649.3	0.40	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000597.4	0.38	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000664.5	0.37	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000595.3	0.37	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001911.3	0.37	terpene	raimonol	Streptomyces anulatus
BGC0001529.5	0.37	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000678.5	0.36	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

Regulator	Description
CcpA	Catabolite control protein A

NZ_MCIF01000002.1 - Region 6 - ranthipeptide

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Location: 1,722,757 - 1,744,418 nt. (total: 21,662 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001160.5	0.57	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.55	NRPS	peramine	Epichloe festucae
BGC0000866.5	0.54	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.52	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000189.4	0.44	PKS	3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole	Xenorhabdus bovienii SS-2004
BGC0002474.2	0.44	NRPS	agrobactin	Agrobacterium tumefaciens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001160.5	0.57	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.55	NRPS	peramine	Epichloe festucae
BGC0000866.5	0.54	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.52	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000189.4	0.44	PKS	3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole	Xenorhabdus bovienii SS-2004
BGC0002474.2	0.44	NRPS	agrobactin	Agrobacterium tumefaciens

Regulator	Description
CcpA	Catabolite control protein A

NZ_MCIF01000002.1 - Region 7 - lanthipeptide-class-ii,redox-cofactor

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Location: 2,088,356 - 2,118,942 nt. (total: 30,587 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000525.5	0.38	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000500.5	0.37	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.36	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002704.2	0.35	ribosomal	archalan β	Halorussus salinus
BGC0002703.2	0.35	ribosomal	archalan α	Halorussus salinus
BGC0000504.5	0.35	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001391.3	0.35	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000623.3	0.35	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.58	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.50	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002704.2	0.49	ribosomal	archalan β	Halorussus salinus
BGC0001407.5	0.49	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000504.5	0.49	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001391.3	0.49	ribosomal	thusin	Bacillus thuringiensis serovar rongseni

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
RpoN	Regulator of nitrogen assimilation and virulence

NZ_MCIF01000002.1 - Region 8 - RRE-containing,azole-containing-RiPP

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Location: 2,514,679 - 2,547,399 nt. (total: 32,721 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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binding site

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.31	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002144.3	0.31	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0001655.3	0.29	ribosomal	LP2006	Nocardiopsis alba DSM 43377
BGC0001779.5	0.27	ribosomal	siamycin	Streptomyces nodosus
BGC0000563.4	0.26	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002575.2	0.26	ribosomal	cochonodin I	Streptococcus suis
BGC0001226.4	0.26	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001660.3	0.25	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0002015.4	0.24	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000616.4	0.24	ribosomal	amylocyclicin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0002144.3	0.47	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0002115.3	0.47	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001184.4	0.46	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000894.4	0.45	other (other)	citrinin	Monascus aurantiacus
BGC0001655.3	0.45	ribosomal	LP2006	Nocardiopsis alba DSM 43377
BGC0002496.3	0.45	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0001197.5	0.44	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002575.2	0.44	ribosomal	cochonodin I	Streptococcus suis

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A

NZ_MCIF01000002.1 - Region 9 - betalactone

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Location: 4,538,462 - 4,564,027 nt. (total: 25,566 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001441.5	0.44	other (other)	belactosin A, belactosin C	Streptomyces sp.
BGC0001050.5	0.40	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0000904.5	0.39	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000188.5	0.39	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0002316.2	0.39	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0002706.2	0.38	NRPS	saframycin Mx1	Myxococcus xanthus
BGC0000550.3	0.38	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0002007.2	0.37	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0002017.3	0.37	NRPS	potensibactin	Nocardiopsis potens DSM 45234

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001441.5	0.44	other (other)	belactosin A, belactosin C	Streptomyces sp.
BGC0001050.5	0.40	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0000904.5	0.39	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0000188.5	0.39	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0002316.2	0.39	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0002706.2	0.38	NRPS	saframycin Mx1	Myxococcus xanthus
BGC0000550.3	0.38	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0002007.2	0.37	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0002017.3	0.37	NRPS	potensibactin	Nocardiopsis potens DSM 45234

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
DasR	N-acetylglucosamine dependent repressor
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_MCIF01000002.1 - Region 10 - terpene

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Location: 4,647,904 - 4,668,866 nt. (total: 20,963 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

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core biosynthetic genes

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.70	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000645.3	0.56	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000656.5	0.49	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000646.5	0.48	terpene	β-carotein	uncultured bacterium
BGC0000648.3	0.44	terpene	carotenoid	Myxococcus xanthus
BGC0000638.3	0.43	terpene	carotenoid	Pantoea ananatis
BGC0000630.3	0.43	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0001336.5	0.42	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000635.3	0.42	terpene	carotenoid	Paracoccus sp. N81106
BGC0002554.2	0.42	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.70	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000645.3	0.56	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000656.5	0.49	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000646.5	0.48	terpene	β-carotein	uncultured bacterium
BGC0000648.3	0.44	terpene	carotenoid	Myxococcus xanthus
BGC0000638.3	0.43	terpene	carotenoid	Pantoea ananatis
BGC0000630.3	0.43	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0001336.5	0.42	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000635.3	0.42	terpene	carotenoid	Paracoccus sp. N81106
BGC0002554.2	0.42	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

NZ_MCIF01000002.1 - Region 11 - terpene

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Location: 4,863,532 - 4,884,287 nt. (total: 20,756 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001896.4	0.44	other (other)	carbazomycin B	Streptomyces luteoverticillatus
BGC0002493.3	0.44	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000648.3	0.42	terpene	carotenoid	Myxococcus xanthus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001882.3	0.42	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000204.5	0.42	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002218.2	0.41	terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613
BGC0002635.2	0.40	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001896.4	0.44	other (other)	carbazomycin B	Streptomyces luteoverticillatus
BGC0002493.3	0.44	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000648.3	0.42	terpene	carotenoid	Myxococcus xanthus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001882.3	0.42	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000204.5	0.42	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002218.2	0.41	terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613
BGC0002635.2	0.40	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

NZ_MCIF01000002.1 - Region 12 - terpene-precursor

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Location: 5,573,851 - 5,594,894 nt. (total: 21,044 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

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core biosynthetic genes

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regulatory genes

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binding site

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.3	0.37	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001521.3	0.33	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0002294.3	0.33	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000595.3	0.33	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001483.4	0.32	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001430.4	0.29	NRPS, PKS	myxochromide S	Stigmatella aurantiaca Sg a15
BGC0002386.2	0.28	NRPS, PKS	cyclo(n-Me-L-Leu-L-Val), cyclo(n-Me-L-Leu-L-Leu), cyclo(n-Me-L-Leu-L-Ile)	Sorangium cellulosum So0157-2
BGC0000544.4	0.28	ribosomal	planosporicin	Planomonospora alba
BGC0000997.4	0.28	NRPS, PKS	glidobactin, glidobactin B, glidobactin C	[Polyangium] brachysporum
BGC0000845.5	0.28	other (non-nrp beta-lactam)	clavulanic acid	Streptomyces clavuligerus ATCC 27064

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.3	0.37	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001521.3	0.33	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0002294.3	0.33	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000595.3	0.33	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0001483.4	0.32	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8
BGC0001430.4	0.29	NRPS, PKS	myxochromide S	Stigmatella aurantiaca Sg a15
BGC0002386.2	0.28	NRPS, PKS	cyclo(n-Me-L-Leu-L-Val), cyclo(n-Me-L-Leu-L-Leu), cyclo(n-Me-L-Leu-L-Ile)	Sorangium cellulosum So0157-2
BGC0000544.4	0.28	ribosomal	planosporicin	Planomonospora alba
BGC0000997.4	0.28	NRPS, PKS	glidobactin, glidobactin B, glidobactin C	[Polyangium] brachysporum
BGC0000845.5	0.28	other (non-nrp beta-lactam)	clavulanic acid	Streptomyces clavuligerus ATCC 27064

Identified secondary metabolite regions using strictness 'relaxed'

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(Thi)azol(in)e containing peptide(s)

antiSMASH-DB 4.0 matches for A4R35_RS01835

MIBiG 4.0 matches for A4R35_RS01835

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Lanthipeptide(s) for A4R35_RS08415

antiSMASH-DB 4.0 matches for allorf_2097064_2097252

antiSMASH-DB 4.0 matches for allorf_2097116_2097262

antiSMASH-DB 4.0 matches for allorf_2100794_2100880

antiSMASH-DB 4.0 matches for allorf_2104594_2104782

MIBiG 4.0 matches for allorf_2104594_2104782

antiSMASH-DB 4.0 matches for allorf_2105177_2105404

antiSMASH-DB 4.0 matches for allorf_2105226_2105342

antiSMASH-DB 4.0 matches for allorf_2105269_2105430

antiSMASH-DB 4.0 matches for allorf_2109779_2109943

antiSMASH-DB 4.0 matches for allorf_2109786_2109992

antiSMASH-DB 4.0 matches for allorf_2109823_2109933

MIBiG 4.0 matches for allorf_2109823_2109933

antiSMASH-DB 4.0 matches for allorf_2113114_2113341

antiSMASH-DB 4.0 matches for allorf_2113382_2113621

antiSMASH-DB 4.0 matches for allorf_2113463_2113609

antiSMASH-DB 4.0 matches for allorf_2113667_2113735

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Regulator	Description
CatR	H2O2-responsive repressor
CcpA	Catabolite control protein A
GnfM	Regulator of nitrogen-fixation genes
RutR	Regulator of the pyrimidine and purine metabolism