LOCUS       NZ_MCIF01000002        20756 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Thermogemmatispora tikiterensis strain T81 A4R35_scaffold00002,
            whole genome shotgun sequence.
ACCESSION   NZ_MCIF01000002
VERSION     NZ_MCIF01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Thermogemmatispora tikiterensis
  ORGANISM  Thermogemmatispora tikiterensis
            Bacteria; Bacillati; Chloroflexota; Ktedonobacteria;
            Thermogemmatisporales; Thermogemmatisporaceae; Thermogemmatispora.
REFERENCE   1  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Analysis of Carbohydrate Active Enzymes in Thermogemmatispora T81
            Reveals Carbohydrate Degradation Ability
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-AUG-2016) Faculty of Agricultural and Food Sciences,
            University of Manitoba, 66 Chancellor's Circle, Winnipeg, Manitoba
            R3T 5V6, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2011
            Assembly Method                   :: Newbler v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 25.9x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003268475.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 03:19:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,660
            CDSs (total)                      :: 4,607
            Genes (coding)                    :: 4,541
            CDSs (with protein)               :: 4,541
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 8 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 6 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:11:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4863531
            Orig. end                         :: 4884287
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MCIF01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20756
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="11"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20756
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20756
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10756](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10756)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(802..1704)
                     /locus_tag="A4R35_RS19470"
                     /old_locus_tag="A4R35_19325"
     CDS             complement(802..1704)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017720411.1"
                     /locus_tag="A4R35_RS19470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19325"
                     /product="NotI family restriction endonuclease"
                     /protein_id="WP_112432330.1"
                     /transl_table=11
                     /translation="MVPLPRHPLAEVFGFPTTNFSAEAERHRQLKLCPFHNHVPTCTKD
                     KAEQPLGVCSVFEGSNIVITCPIRFRENWLAIRDAATFFFPPGAQWTVLSEVRLNDRFG
                     QSAGNLDFVLAAYDHLGKIIDFGALEVQAVYISGNVRAPFEQYMADPQQRANMDWSRQR
                     FYPRPDYLSSSRKRLAPQLLYKGAILSSWGKKMAVAVESNFFATLPQMEETAPEYAEIA
                     WLIYDLQYREQENRYHLTRTRTVYTAFQTALTKIITAEPGHLGDFLQLLQSRLDSKREN
                     GDRQKSLFQLSEPHEWEED"
     misc_feature    complement(1873..1889)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.64"
                     /tool="antismash"
     gene            complement(2087..3358)
                     /locus_tag="A4R35_RS19475"
                     /old_locus_tag="A4R35_19330"
     CDS             complement(2087..3358)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0000272 - polysaccharide catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007915716.1"
                     /locus_tag="A4R35_RS19475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19330"
                     /product="cellulase family glycosylhydrolase"
                     /protein_id="WP_112432332.1"
                     /transl_table=11
                     /translation="MQDAHAETPRPQASRRAFLEAIAAAGLSFWAAGTGLGAGTAFARP
                     SADAASSSRFTAASLRQQRNSFVSRRGPFFILDGQPFYFAGTNNYYMHYQSHFMIDDVL
                     KDVAAMGLPVLRIWGFLDGQPHNGFVMQPEPGVYPEDGYERFDYTVWRAGQLGIKLVVP
                     FVNNWDDFGGMNQYVAWFGASGHDDFYTNPQIKAAYKAYVRHFIHRVNRYTGKPLYLDP
                     TIMTWELANEPRCQSDPSGQTLTAWVHEMSAFIKSMDGLHLVAVGDEGWYNEPGNSDWA
                     YNGSQGVDWKRLVALPTVDYGTLHLYPDYWGKDNAWSLQWIADHIHDGHALGKPVVLEE
                     YGWLDMATRDDIYRQWTDQVYRLNGNGDQFWILTGLQDDGTLYPNYDGFRVTYPSSTAT
                     VIAQHEAQMRAKSERSGRGPRVGT"
     misc_feature    3418..3431
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.54"
                     /tool="antismash"
     misc_feature    complement(3460..3475)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.32"
                     /tool="antismash"
     misc_feature    complement(3494..3512)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.86"
                     /tool="antismash"
     misc_feature    3533..3546
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 20.35"
                     /tool="antismash"
     misc_feature    complement(3554..3565)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.38"
                     /tool="antismash"
     gene            3598..4710
                     /locus_tag="A4R35_RS19480"
                     /old_locus_tag="A4R35_19335"
     CDS             3598..4710
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007919458.1"
                     /locus_tag="A4R35_RS19480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19335"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_112432334.1"
                     /transl_table=11
                     /translation="MANTVTLRDIAREAGVSVGTVSRVLNNHGNVTEETRQRVLRAASR
                     LGYFSGVRQGVGDEERPPVEGRVVREIGFLFCSFLPKTTVSTNPFWSHILHGVESEARR
                     ANVKVTYRAISEIQEDPDRLLTTIYDMRLGGILLVGPAEAVTVQTIQQAGTPLVLVDNY
                     VPQTDAVLGNNLDGARQAVEYLISLGHRRIAFMGGPFVEKTGQEAEQHRQRPPRNRVYT
                     IERRAQGYRLALLEAGLPIVPELYEDGGLSMEGGYLACKRLLERGEQFSAIFCANDEMA
                     VGAMKALREAGLRLPEDISIVGFDDIDMVEHLTPALTTVRVNKEALGAVALRRLLALIS
                     HPDPVHVVSMLDVELVKRESACAPPASVRH"
     misc_feature    complement(4792..4812)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.78"
                     /tool="antismash"
     gene            4925..8014
                     /locus_tag="A4R35_RS19485"
                     /old_locus_tag="A4R35_19340"
     CDS             4925..8014
                     /EC_number="3.2.1.23"
                     /GO_component="GO:0009341 - beta-galactosidase complex
                     [Evidence IEA]"
                     /GO_function="GO:0004565 - beta-galactosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014502.5"
                     /locus_tag="A4R35_RS19485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19340"
                     /product="beta-galactosidase"
                     /protein_id="WP_112432336.1"
                     /transl_table=11
                     /translation="MVSLIRSDRVLVFADPAYPRACSQALLRKLLPGPFEVSDASHLAQ
                     ALEDAPRLLVSFHGPYFPKAAWNALLRFLERGGNLAVFGGMPFARPVTAAGEVEPEQDV
                     YARQLCLGPFFPVDLAASGAQPASLRLVAAPEALFLRDCALPLSSERPGRFWACYPRLT
                     QTSDYPEEIGSAGPFDTLLRPLLFAVATTPYGEERLATPAFVLDQLGGRFQGGRWLLSL
                     WEPETAEDWLALAEPIQRLLALALEDPLCCAVRPVLACYRPEEAPALVVTLPERLDLEL
                     RITVTQADDGQVLRRWDFAAPASPVHSERYLQMALPPKAGLYRVHTEYRPVGGQWLSQE
                     TGFWIWDEALIAATRGKRLVAGRDYFYQGERLFLVCGTTYMDSRVQRKYWRLPNPARWE
                     REMAEMKAAGINLLRTGLWTAWRDVLPVAGVPTESFLRALDAFVLTACRQELQVIFTFF
                     AFFPPLFDGLNPWLDPRSLEAQERFLSLLARRYAQVELLSWDLINEPSFGDPARAFAQR
                     PLPNYDRYEQQAFVQWLKERYTLEQLQLRWRETPAELSSWEQLRLPREADYSTSVRDTT
                     ARAMLKVADYTRFSQEMFVTWARRMYRAIRAAGSQTLIGVGQDEAGARIAPQFYATAVD
                     YTTTHPWWNVDDLLWDMLLDKTPERPNLIQETGVMLVRDVDGRPWRTEQANAWLLERKL
                     IMGLMANGAGLIQWLWHTNAYMTSENENSIGLVRADGSAKPELLVMREFCRLAEALADQ
                     LQEAPEPPPVWLVIPYSQWFVRPDLGALPTRQAVRALAYELGVIPQLIGEQRLASELER
                     TGHRPQLIILPALQLCEPAAWFAVLDYVQRGGTALVSGVVGRDMHNLPFNPHLNYGAGL
                     PAPEPVAPYEVLRLEDGSRYQLSFTQEKTGYVRKAHNELRELQMGAGRLLWAGLPVELA
                     GELEPLARLYQRALGKTPLEPLPEGWRRPWLLVRRPLKEGRLLLVASEAGDEQRLSLAE
                     EGLTLAVAPQRAGAVLWRPGEPPRLFGGLRAVAADGPAHE"
     misc_feature    complement(8034..8050)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 22.72"
                     /tool="antismash"
     misc_feature    8082..8095
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.57"
                     /tool="antismash"
     misc_feature    complement(8101..8117)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.02"
                     /tool="antismash"
     gene            8555..9928
                     /locus_tag="A4R35_RS19490"
                     /old_locus_tag="A4R35_19345"
     CDS             8555..9928
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007920823.1"
                     /locus_tag="A4R35_RS19490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19345"
                     /product="MFS transporter"
                     /protein_id="WP_112432338.1"
                     /transl_table=11
                     /translation="MATVSETSPVTVRRMVPILAASTVGTAIEWYDFFLYGFLSATVFP
                     KLFFPELDPVAGTIASFTTNFVGFFARPLGGAFFGWFGDRVGRKSTLIATLLLMGIATA
                     LMGLLPGHAQIGLAAPLILSVLRFLQGAGVGGEWGGSVLLSMEYGDNRRRGFWMSWPQT
                     GVPLGLALAAIAVLSFQAIFPGEAFLSIGWRIPFLLSLLLILVGLYIRLRILETPAFRR
                     VKETGRIAHVPLVEVFRHYWREIILSALVRSAEQAPFYLFTTFILSYGSKTLKVDSSVL
                     YAGLIISAVCSLILMPTWSHLSDRFGRKRWYMIGCVLMALYAFPYFLLLETRLPVVVLL
                     AMILSISFCHDWLYGPQAALISERFGTRLRYSGASLGYQLASITAGGPAPILATWLVAN
                     THTWLGSGTPSYTLIAVFIIFMAVVSFISTALLGRELAGQAAVEDVGGEETRLTTQVQ"
     gene            complement(10001..10393)
                     /locus_tag="A4R35_RS19495"
                     /old_locus_tag="A4R35_19350"
     CDS             complement(10001..10393)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03462.1"
                     /locus_tag="A4R35_RS19495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19350"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_112432340.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 5.3e-20,
                     bitscore: 69.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHATYLLFLLAWALPILGLQWLVGWRKLWIWRRRWPWAVLLVGS
                     YLTLTDSLAIAQHIWFFQPTLILGLTLGNVPLEEALFYFLTAAMIAQGYVLLLPSLTIS
                     SGSGTGSPPGPSSSGSHKRRGGQLRR"
     gene            complement(10400..10756)
                     /locus_tag="A4R35_RS19500"
                     /old_locus_tag="A4R35_19355"
     CDS             complement(10400..10756)
                     /GO_function="GO:0016872 - intramolecular lyase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03462.1"
                     /locus_tag="A4R35_RS19500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19355"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_189362057.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 3e-17,
                     bitscore: 61.0, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYAGFLLLFLLAPIGSLILLLGRRLLCRRYWLTTALLAAIVLLA
                     MAPWDHAAVARGIWNWSPAQTWGLRLWLIPLEEYLFALLETLLTTLLLYALLRSGPTPV
                     PPLPGEEITTRKGV"
     gene            complement(11203..12603)
                     /locus_tag="A4R35_RS19505"
                     /old_locus_tag="A4R35_19360"
     CDS             complement(11203..12603)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019426069.1"
                     /locus_tag="A4R35_RS19505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19360"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_112432344.1"
                     /sec_met_domain="Aldedh (E-value: 2.4e-143, bitscore:
                     476.1, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTMSQSSAAARAVIVRDKWSGEVIGELPRAGEREIEQALQAAEQ
                     ARRRPWPARERAAVLQRAVALLEERRTAVLETMRRETGFSRKDVEQEFARAVVTLTLCA
                     QEALRLGGEVVPLDASPGFEQRLALTIRVPVGIVLAITPFNAPLNTVCHKIGPALAAGN
                     AVILKPAELTPLTAALLAQILDEAGLPEGRLQVLYGSGSEVGLRLLRDPRIGFTTFTGS
                     TEVGAIVKRETGLRPVSLELGSVSATIICADADLERAARDVAHAGYRKAGQVCTSVQSL
                     FVHTSVEREFVERLSAQVAALKSGDPADPATEVGPLISESAAARACALVEEALRSGARV
                     LVGGTCTGTLFQPTLLHEVAPPMRITREEIFAPVVSIVRFERLDEAIEAANASRYGLQA
                     GVYTSSLATALELARRLEVGGVIINGTSSTRADGMPYGGMKDSGFGKEGPAYAIREMTV
                     ERLVMLGP"
     gene            complement(12792..14306)
                     /gene="tcuA"
                     /locus_tag="A4R35_RS19510"
                     /old_locus_tag="A4R35_19365"
     CDS             complement(12792..14306)
                     /codon_start=1
                     /gene="tcuA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379922.1"
                     /locus_tag="A4R35_RS19510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19365"
                     /product="FAD-dependent tricarballylate dehydrogenase TcuA"
                     /protein_id="WP_112432346.1"
                     /sec_met_domain="DAO (E-value: 6.9e-14, bitscore: 50.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEYYDVIVVGGGNAGLSAAHAAREQVDKVLVLEKAGSDWAGGNS
                     YFTAGAFRTTFSSLEELLPLLDERDEAFLQRTALPPYTPEQFLQDMQRTTKGRCDPELT
                     AILVQEAAETIRWLHQKGLRFRLMYDRQSFQVDGEFRFWGGLALGTVNGGKGLIEQHLQ
                     AAAASGIEVRFNSPVVDLECDMTGAVCGVICSPPGRERQRIRAGAVVLAAGGFEANPQL
                     RTCYLGPGWDLARVRGTPYNTGEVLFAALALGAQSYGHWSGCHSVAWDVAAPPHGDRFL
                     TNLLTKQSYPLGIVVNSQGKRFLDEGADFRNYTYARYGAEIMKQPDGIAFQLFDAKTEP
                     LLRKDEYTAPGVSRFEALTIRELAQKAGIDADGLEETVTTFNAAVMRDVKFNPAIKDGK
                     GTVGITPRKSNWAQPLDTPPYYAFAVTCGITFTFGGLRIDPNGRVLDRLNLPMPGLYAA
                     GELVGGLFYHNYPGGAGLMAGSVFGRRAGRAAGQWSRERRALDRAS"
     gene            complement(14303..14611)
                     /locus_tag="A4R35_RS19515"
                     /old_locus_tag="A4R35_19370"
     CDS             complement(14303..14611)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019491.5"
                     /locus_tag="A4R35_RS19515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19370"
                     /product="Dabb family protein"
                     /protein_id="WP_112432348.1"
                     /transl_table=11
                     /translation="MIRHIFLGKARAEATPEQLEELCAAWRSLVGQVPGLRSLVAGRNI
                     SPRDQQYTVALVADLDDMEAWERYMQHPAHVAISQRLTSKLIQSDGRAMVQLVMEGQ"
     gene            complement(14694..15452)
                     /locus_tag="A4R35_RS19520"
                     /old_locus_tag="A4R35_19375"
     CDS             complement(14694..15452)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (10-129). E-value: 1.6e-11.
                     Score: 36.4. Matches aSDomain:
                     nrpspksdomains_A4R35_RS19520_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013651637.1"
                     /locus_tag="A4R35_RS19520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19375"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_112432350.1"
                     /sec_met_domain="adh_short (E-value: 1.1e-31, bitscore:
                     108.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6e-31, bitscore:
                     106.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGERLKERIAVITGAARGNGRAIAEAYAREGASVVIADIMEEAAR
                     QTAAELAQATGQRVVGKHLDVTNATEVNELATWTVREFGRVDILVNNAGVIGRYDFLEI
                     TEAEWDRVLDINLKGTFLCGQAFARRMKEQGGGVIINIASVNAESVNPTTVHYCTSKGG
                     VRTLTKAMALALVKANIRVNAIGPGPIYTELSKDRLDDPQSLAATLAHIPMGRVGQPSD
                     LAGAAVFLASDESAYITGITLYVDGGWLTM"
     aSDomain        complement(15066..15422)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R35_RS19520_PKS_KR.1"
                     /evalue="1.60E-11"
                     /label="A4R35_RS19520_PKS_KR.1"
                     /locus_tag="A4R35_RS19520"
                     /protein_end="129"
                     /protein_start="10"
                     /score="36.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VITGAARGNGRAIAEAYAREGASVVIADIMEEAARQTAAELAQAT
                     GQRVVGKHLDVTNATEVNELATWTVREFGRVDILVNNAGVIGRYDFLEITEAEWDRVLD
                     INLKGTFLCGQAFAR"
     gene            complement(15646..16116)
                     /locus_tag="A4R35_RS19525"
                     /old_locus_tag="A4R35_19380"
     CDS             complement(15646..16116)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MannoseP_isomer"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012417.5"
                     /locus_tag="A4R35_RS19525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19380"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_112432352.1"
                     /sec_met_domain="MannoseP_isomer (E-value: 6.4e-06,
                     bitscore: 24.2, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASPSFEPRPSSIPKEVDEVRPVRAEELVWVEPPQHHEAYSKLL
                     VNPDNSRTRYFDFRLSLYQPRGYAENHVHEEAEHVYYILKGRGLMRLGERQYVVEPHTA
                     IFIPPGVVHSLANTGLEDLLFIVVTVPAGELERRDRREDEINHPDESASPGV"
     gene            complement(16113..17915)
                     /locus_tag="A4R35_RS19530"
                     /old_locus_tag="A4R35_19385"
     CDS             complement(16113..17915)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008962621.1"
                     /locus_tag="A4R35_RS19530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19385"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_112432354.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.6e-45, bitscore:
                     151.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.6e-36, bitscore:
                     121.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAIKGAELIVDFLIRRGVPYVFGLCGHGILGFLDAVYDRRDELK
                     AISVHHEACAAFMADAYFRVAQRPVATFTSCGPGSTNLVPAIASAFMDSSAFLAITGNV
                     PTSQWNRGPFQESGRYFQGEFVNVLRPYVKRSFQPTRADMLPLALRQAYTLMLSGRPGP
                     VHLDVPLNVFVETVEREEAERELWDCPIASRAGADPADLQEALRLLLSAQRPVIVAGHG
                     VELSQAESELLRLAEQLSIPVVTTPLGKGVIDARHRLSLGATGRNGSYPANAATRHADV
                     ILALGTRFDDRSTSSWLPGFTYRIPPTRLIHVDIDPSEIGRNYQPTVGIVGDIRTVLRQ
                     LLEALSACATTALETRAAARRSWLEKIGEWQRKWEAHVNEPRRSEAVPLRPERVISELR
                     AALPEDAIVVSDVGVHHNWLVSAFPAYRSRTLLQSFGFASMGFGVAGALGAKLAAPERS
                     VVSVCGDGGFLMWPGTVATAVEYAIPVVWLVWNNYGYCSIRDQQLGYFGSGRELVTSFV
                     EEQSGRLFSADFAALARAMGADGYLVERPGDLGDLLHQALTSGRPTVLDVRVDREVRPP
                     ATASWELPPLPHPLPNFGWQEDQL"
     misc_feature    complement(17905..17919)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            complement(18029..18760)
                     /locus_tag="A4R35_RS19535"
                     /old_locus_tag="A4R35_19390"
     CDS             complement(18029..18760)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013704829.1"
                     /locus_tag="A4R35_RS19535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19390"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_112432356.1"
                     /transl_table=11
                     /translation="MPELLQLQQVSGGYHGRTVVHEVSLSIAEGEAVAAVGANGAGKTT
                     LLRLIMGQLPLSGGQVFFAGRDLARLPPFERVRLGIGYVPEGRALFPEMTVEENLEIGA
                     YRASRADLRQRLAYIYQIFPKLQRLRQTRCRLLSGGEQQMVTVGRALMTHPRLLILDEP
                     STGLAPRVVGELYQALRALHAGGLTVFVVEQNAYAALRFAQRGYVFEDGHITRVAPAAE
                     LLHDPRLVESYVGRASPMASS"
     gene            complement(18753..20534)
                     /locus_tag="A4R35_RS19540"
                     /old_locus_tag="A4R35_19395"
     CDS             complement(18753..20534)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF014684.5"
                     /locus_tag="A4R35_RS19540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_19395"
                     /product="branched-chain amino acid ABC transporter
                     ATP-binding protein/permease"
                     /protein_id="WP_112432358.1"
                     /transl_table=11
                     /translation="MRRRHIRPTFPGWRATGLFKQEGAWLIFGVAVVAGVLIALFGNGD
                     QAQLLFSTCLFVVLAYAWNIISGLSGYVSFGQVGFFGIGAYVAATCQIAWQWDWYLAAL
                     GAVLAAVLLALPLGTVMLRLQGIFFALGMFGLSHIGALIATSTPLVGGSMGEPVPIVGS
                     TQETALVMLACAVGSVLLTAWLLRSPLGLRLLALRDDEKAAEASGINTNASKVVAFCLS
                     AGLAALAGALYVWNVGFIDPGSAFNNTYELQTILMVLFGGIGTLWGPLLGAVVISLISN
                     ALWAQFPQQQQIILGALILIAVLWMPGGLVSLFQRFGWLRRRPVWGPPPMIEAEARRAL
                     FPAAVSRTGEPALRCEEITRRFGGLTALNRVNLEARSGQIVAVIGPNGAGKTTLFNLIT
                     GFDRCNGGTIRFGETLLNRLAPYRIARAGIARTFQTCRPFPSLTAWETLLLPALAAGIP
                     KEETIRTATQMLERLALREQWDASPEGLPPGQLRFLEIGRALMLRPRVLLLDEVMAGMS
                     PEEIHLVHALLREAVAAGCAVVAIEHVVPAIMPIADHVYVLDFGTTIAQGRPDEVLRNP
                     AVIEAYLGTGEEAPVNA"
ORIGIN
        1 gagggcctcg tgatcaagct cagcgtagcg gtagagacgg cgcccggctc tcttgccggt
       61 gagggtatag ggagggtcaa taaagctgac cacgtcatgg cgttccaggt agtggcgcag
      121 caactccagg ccgtcgcctt gtctgaaggt gaggcgtgga ctcaggcggg cgatctcctc
      181 gatgcgccgc cgcagcgtgg ctggatacca gcgcgagcgc aagccgcgtc caccttcgcc
      241 gtgcttgaga agaccggcgc ccggggccag aataccgccg tggctgacgc ggttgcggag
      301 caaggtctga aaagcgtgct cggcgagggc aagagagtgg cgctcgcggg ccagccagtc
      361 ctccactcct gcaggtgtca gctcgaaaga gtgcagaagc tgcagaagct gagtgcgtgc
      421 actctcttgc aagagtgctt gccagaccgc tgctacatcc tcgtccagct ctaccatcag
      481 cgcccgttcg accaggccct ctgccactgc tgtcaggctg acgctgccgc caccggcgaa
      541 gggttctagc agcacagtcg ggcgcgctgg cgacagacca cgggccgctc tgctcgcggg
      601 agagagccag cggcgtatgt aagggacaag ccaggtcttg ccacctggat agcgaaaggg
      661 gctacgttgg ggcacgctgg ctacattgat gggccgtgcc agttccccct ggctggggat
      721 agggctgctg gagctgctga ccacggggcc atcagcaaag agagggacca tcaacgagaa
      781 gggttgttct tttgaagcca ctcaatcctc ctcccactca tgcggctccg aaagctgaaa
      841 gaggcttttc tgccgatctc cgttttcccg cttggagtca agccggctct ggagcaattg
      901 caagaaatcg cctagatggc ctggctccgc tgtaataatt tttgtaaggg ctgtctggaa
      961 agcagtgtaa acagttcttg tgcgtgtaag atgatagcgg ttttcctgct cccgatactg
     1021 gagatcgtag atcaaccagg caatttctgc atactcagga gcggtctctt ccatctgtgg
     1081 caaagtggca aaaaaattgc tttcaacagc aactgccatc tttttccccc aagacgagag
     1141 aattgcccct ttatacaata gctgcggagc tagacgttta cgagaagatg aaagatagtc
     1201 gggccgagga tagaagcgct gccgtgacca gtccatattg gctcgttgct gaggatcggc
     1261 catatactgc tcaaaaggag cgcgaacatt gccagaaata tacacagcct gtacttccaa
     1321 tgcaccaaaa tcaataatct tacccagatg atcgtacgcg gcaaggacga agtcgaggtt
     1381 acctgctgac tgcccaaagc gatcgttcag acgaacctct gaaagcactg tccactgcgc
     1441 tcccgggggg aagaagaacg tggcggcatc tctgatagca agccagtttt ctcgaaaacg
     1501 tatgggacag gtgatgacaa tgttacttcc ctcgaaaacg ctgcataccc caagaggctg
     1561 ttcggctttg tctttcgtac acgtgggcac atggttatgg aaagggcaaa gcttgagttg
     1621 tcggtggcgc tctgcctctg cagagaaatt cgtggtgggg aaaccaaaga cttctgccag
     1681 ggggtgtcta ggtagcggaa ccatgcttgc tgtcttcctc caggaaaagg aagggactct
     1741 tagagaaatc tctctttcac gcttgtccag cgatcatgca agtcactggg cttgcgcagc
     1801 agctgggtca gctctatttt ctctcctttg tcaagagatt ctcccaagcc tctcggcctt
     1861 agaaggctct gttgcctctt tcttgttcag gtgagaaggg tgcgagagca gatggtagtg
     1921 gcggtccagg catcctcaaa agtgactgcc tggaccgggc gatccaggca gtccagtgtc
     1981 acaacaagca ggaaacccag ggcgtgaggg tgtgagtgtg gtggttgatg gtagcgatct
     2041 gcttgctcat cgagcgtgct ctacgcacgc tcacgccatt ccggcgctac gttccgaccc
     2101 gagggccacg cccagaccgc tcggatttag cccgcatctg ggcctcatgt tgggcgatca
     2161 ccgtggccgt gctgctcgga tacgtcacgc ggaaaccatc atagttcggg tagagcgtgc
     2221 cgtcgtcctg caggcccgtc agaatccaga actgatcacc gttgccgttc aagcgataga
     2281 cctggtcggt ccactgccga tagatatcat cgcgcgtagc catgtccagc cagccatact
     2341 cttccagaac taccggcttg cccagcgcat ggccatcgtg aatatgatcg gcgatccact
     2401 gcaatgacca ggcgttgtct ttgccccagt agtccgggta caggtgtaac gtcccgtagt
     2461 ccactgtggg aagagcgacc aggcgcttcc agtccacgcc ctgactgccg ttataggccc
     2521 agtcggagtt gcccggctcg ttgtaccagc cttcgtcacc gaccgccacc agatggaggc
     2581 catccatgct cttgatgaag gcgctcattt catgaaccca ggccgtcagg gtctggccgc
     2641 tggggtccga ctgacagcgc ggctcgttcg ccagctccca ggtcatgatg gtcggatcga
     2701 gatagagcgg tttgcctgtg taacggttca cgcggtggat gaagtgacgc acgtaggctt
     2761 tgtaggcggc cttgatctgg ggattggtgt agaagtcatc atgaccgctg gccccgaacc
     2821 aggccacgta ctgattcatg ccgccgaagt cgtcccagtt gttgacgaac ggtaccacca
     2881 gcttgatgcc aagctgcccc gcacgccaga cggtgtagtc gaaacgctcg tagccatctt
     2941 caggatagac gcctggctca ggctgcatga caaaaccatt gtgcggctgc ccgtcgagaa
     3001 aaccccagat acgtaagact ggcaggccca tagcggcgac atccttgagg acgtcgtcga
     3061 tcataaagtg agattgataa tgcatataat agttgttggt gccagcgaaa tagaaaggct
     3121 ggccgtccag aatgaagaaa ggcccgcgcc ggctcacgaa actgttgcgt tgctgccgca
     3181 ggctggccgc cgtgaaacga gaggatgatg ccgcatcggc actggggcgc gcaaaagccg
     3241 ttcccgcacc caagcccgta cccgccgccc agaagctcag accagcggcg gctatagctt
     3301 ccagaaaagc tctcctgctc gcttgtggtc gcggggtctc agcatgtgca tcctgcatat
     3361 gctctgctcc ttcctggatg agtggctgcg ctccagatgg ttcaatgaac aatgcaaatt
     3421 tttcaatgaa ccgttacacg gaagaatggt accatcttac cgaccattct gtcaataggt
     3481 gccccttctc atggttgagc atcattctga tgaccacgag ccggccttaa gattgacaga
     3541 tatcaatatt gatgttatct ttttcgtgaa cgtttcacag ccttggagga atcggcgttg
     3601 gcaaacactg tcaccttgag agacatcgcg agggaggcgg gagtctcagt cggcaccgtt
     3661 tcgcgagtcc tcaacaacca cggtaacgtg accgaagaga cgcgccagcg cgtgctacgc
     3721 gcggcctcgc ggctcggcta ctttagcggg gtgaggcagg gagtggggga cgaagagcgg
     3781 ccacctgttg aagggcgcgt tgtcagagag atcggctttc tcttctgctc ctttctgccc
     3841 aagaccacgg tttccaccaa tccattctgg tcgcatatcc tgcacggtgt cgagagtgag
     3901 gcgcggcggg ccaatgtcaa agtgacctat cgcgccatta gcgagatcca ggaggaccct
     3961 gatcgcctgc tgaccactat ctatgacatg cgtctcgggg gcatcttgct ggtcggtccg
     4021 gcggaggccg tcaccgtgca gaccatccag caggcaggca cgccgctggt cctcgttgac
     4081 aattacgttc cccagaccga tgccgtcttg gggaataacc tggatggcgc gcgccaggcc
     4141 gttgaatatc tgatcagtct gggccatcgc cgcatcgcct tcatgggtgg tccttttgtg
     4201 gagaagacag gccaggaagc ggagcagcat aggcagcgac cgccgagaaa tcgcgtctac
     4261 acgattgagc gccgtgctca ggggtatcgt ctggccctgc tggaggctgg cctgcccatt
     4321 gtgccagagc tgtacgagga tgggggcttg tcgatggaag ggggctatct ggcctgcaag
     4381 cggctgctgg agcgcggcga gcagttcagc gcgattttct gtgccaacga tgagatggct
     4441 gtaggagcca tgaaggccct gcgcgaggcc gggctacgtc tgcccgagga tatctctata
     4501 gtgggcttcg atgacatcga tatggtagaa cacctgacgc cggctctgac gacggtgcgc
     4561 gtcaataagg aggctctggg cgccgtggcc ttgcggcggc tgctcgcctt gatcagtcat
     4621 cccgaccccg tgcacgtggt ctctatgcta gacgtagagc tggtgaaacg cgagtcagct
     4681 tgtgctcctc ctgcctctgt ccgccactga acctggctcg ctcccggcag gctgagaagg
     4741 aagcgctgtg gttcgtccct gagctgagca gggatgctgc ccgccacccc tcttctggcc
     4801 gatgctctgt ctgggtcgct gcatcctgaa cctggcttgt ttgacgtgtc ggctgatcca
     4861 gcctttgcgc cctttgccag ggcggaagtg cgttgtttgt ctggatgctt ttgtgtgagg
     4921 aacgatggtc tcattgattc gctcagatcg cgtgctggtc ttcgctgatc cggcctatcc
     4981 acgagcttgc agtcaggctc tcctgcgcaa gctactgccc ggcccctttg aggtcagcga
     5041 tgcgtcccac ctggcccagg ctctggagga cgctccgcgt ctcctggtct catttcacgg
     5101 cccctatttc ccaaaagccg cctggaatgc tctgctgcgc tttctggagc gcgggggcaa
     5161 cctggccgtc ttcggtggta tgccttttgc ccggcctgtt accgctgctg gcgaggtgga
     5221 accggagcag gatgtctatg cgcgtcagct ctgcctggga ccgttctttc cggtcgatct
     5281 ggcggcgagc ggggcccaac ctgcttcgct ccgtctggtc gctgccccgg aagcactctt
     5341 cctgcgtgat tgtgctcttc cactatcttc tgagcgccca ggacgcttct gggcctgtta
     5401 tccacgtttg acgcagacgt ccgactaccc tgaagagatt ggctcggcgg gaccgttcga
     5461 tacgctgctg cggccactgc tcttcgctgt cgcgacaacg ccctatggcg aggaacggct
     5521 ggcgacgccg gcttttgtac ttgatcagct gggggggcgc ttccagggag ggcgctggct
     5581 gctctcgctg tgggagcctg agactgcaga ggactggctg gccctggctg aacctattca
     5641 gcgtctgctg gccctggcac tggaagatcc gctctgctgc gccgttcgcc cagtgctagc
     5701 ctgttatcga cctgaagagg cgccagcgct ggtggtgacg ctgcctgagc ggctggatct
     5761 ggagctgcgt atcacggtga cgcaggccga tgatggccag gttctgcgtc gctgggattt
     5821 cgcagctccg gcctcaccgg tgcattccga gcgctatctg cagatggcgc tgccgcccaa
     5881 agccggcctc tatcgcgtgc acaccgagta tcggcccgtg ggcggccagt ggctgagcca
     5941 ggagacaggc ttctggatct gggatgaggc gctgattgcg gcgacacgcg gcaagcgcct
     6001 ggtggctggg cgtgactatt tttatcaggg cgagcgcctc tttctggtct gcggaacaac
     6061 ctatatggat agccgcgtgc agcgcaagta ctggcgcctg ccgaatccgg cccgctggga
     6121 gcgcgagatg gccgagatga aggctgccgg catcaatcta ctgcgtactg gcctctggac
     6181 agcctggcgc gacgtgctgc cggtggccgg ggtgccaacg gagtcttttc tgcgcgcgct
     6241 cgatgccttt gtgctgacag cctgccgcca agagctgcag gtcatcttta ccttctttgc
     6301 cttctttccc cctctcttcg atggcctgaa cccctggctc gatccgcgct cgctggaggc
     6361 tcaggagcgc tttctctcac tgctagcccg ccgctatgca caggtggagt tgctgtcgtg
     6421 ggacttgatc aatgagccga gctttggcga tccggctcgg gccttcgctc agcgtccgtt
     6481 gcccaattat gatcgctacg agcagcaggc ttttgtacag tggctcaagg agcgctacac
     6541 gctggagcag ctgcagctgc gctggcgcga gacgccggca gagctatctt cctgggagca
     6601 gctgcgcctg ccgcgcgagg ccgactattc gacctcggtg cgcgatacga cggcgcgcgc
     6661 catgctgaag gtggccgact atacgcgttt ttcgcaggag atgtttgtga cctgggcgcg
     6721 gcgcatgtat cgcgccattc gggccgctgg tagtcagacc ttgatcggcg tgggccagga
     6781 tgaggcgggg gcccgcatcg ctccgcagtt ctatgccacg gctgtcgatt atacgacgac
     6841 gcatccctgg tggaatgttg atgatctgct ctgggacatg ctgctcgaca agacgccgga
     6901 gcggcccaat ctgatccagg agacgggtgt gatgctggtg cgcgacgtcg atggccgtcc
     6961 ctggcgtacg gagcaggcca atgcctggct gctggagcgc aagctgatca tgggcctgat
     7021 ggccaatggg gctggcctga tccagtggct ctggcatacc aatgcctaca tgaccagcga
     7081 gaacgagaat agcatcggcc tggtccgcgc cgatggcagc gccaagccgg agctgctggt
     7141 gatgcgcgag ttctgtcgcc tggcggaagc actggcggat cagctgcagg aggcgccgga
     7201 gcctccgccg gtctggctgg tgatcccgta tagccagtgg ttcgtgcgcc cggacctggg
     7261 tgccctgcca acgcgccagg cggtgcgagc tttggcctat gagctgggcg tgatcccgca
     7321 gctcattggg gagcagcgcc tggcctccga gctggagagg acagggcatc ggccccagct
     7381 gatcatcttg cctgctctgc agctctgcga gccggcggcc tggttcgctg tgcttgatta
     7441 tgtccagcgc ggtggaacgg ccctggtgag cggcgtcgtt ggacgcgata tgcacaatct
     7501 gcctttcaat ccacatctga actatggtgc cggactgccc gcaccagagc cggtggctcc
     7561 ctatgaggtg ctgcggcttg aggatggcag tcgctatcag ttgagcttta cacaagaaaa
     7621 gacaggttac gtgcgcaagg ctcacaacga gttacgggag ctgcagatgg gagccgggcg
     7681 cctgctctgg gcggggctgc cagtggagct ggctggcgaa ctggagccat tggcgcgtct
     7741 ctatcagcga gcgctgggga agacgccgct ggagccgctg cctgaaggat ggcgtcggcc
     7801 ctggctgttg gtgcgtcgtc cgctcaaaga gggaagactc ttgctggtgg cttccgaggc
     7861 cggcgacgag cagcgcctct cgctggcaga ggagggcctg acgctggcag tagccccgca
     7921 gcgtgcggga gctgtgctat ggcgtccggg agagccgccg cggctctttg gtggcttgcg
     7981 agctgttgca gcagacggac cagctcatga gtgaaggaag acagcgggga aggatactct
     8041 atccgggcat ctgcttcccc gctggcatca agctatggct ctggacagag tccagctgtg
     8101 cagttatact ataactaatt gcataccttc gggaaggcat gcccctcaga cagcgagcga
     8161 ggtagcagtt cgctcatgca gcttgaccag atcggtaaga agaggcaaga ccggacataa
     8221 gtccatctac cggactgacc tgctcctctc tgttgaggga gatctgggcg gtgagggcga
     8281 tgactgcctc actgccgtcc attcatgctg aaagaggcat tgcaagcgac aaacgaatga
     8341 gaagcaagcc gttgcctcgt cgggccagca acgctgccgc ctgccctgtc gtttggtacc
     8401 gcgaaggtga ggccactgct ctggagagtg cccgggggcg caggacgtct gtccctctgt
     8461 gagtcctcgc ttgtcggact gcgctctgca gcttcagtat tcctcgatgc gggaacgtcg
     8521 caattgatcc tgacttcgct tcaaggagga atgcatggca acggtctcag agacgagtcc
     8581 cgtcactgta cgccgtatgg tccccattct ggcggcgagc accgtcggaa cggccatcga
     8641 gtggtacgat ttcttcctct acggtttcct ctcggcgacg gtctttccca agctcttctt
     8701 cccggagctg gatccggttg ctgggacgat cgcttccttt acgaccaact ttgtgggctt
     8761 ctttgcgcgt ccactgggtg gggccttctt cggctggttt ggtgatcgcg tggggcggaa
     8821 gtcgacgctg attgcgacgc tgttgctgat ggggatcgcc acagcgctga tgggccttct
     8881 accaggtcat gctcagattg gtctggcggc gcccctgatc ctttctgtgc tgcgcttctt
     8941 gcagggggct ggcgtcggtg gcgagtgggg gggctcagtc ctgctctcga tggagtatgg
     9001 cgacaatcgc cgtcgcggct tctggatgag ctggccacag accggtgtgc cgctggggct
     9061 ggcgctggcg gccattgctg tcctgagctt tcaggccatt ttccctggtg aggctttcct
     9121 gtcgatcggc tggcgcattc ccttcctgct gagcctgctg ctgatcctgg tcggcctcta
     9181 catccgtctg cgcattctgg agacgccggc ctttcgtcgt gtcaaggaga cggggcgcat
     9241 cgctcatgtg ccgctggtgg aggttttccg gcattactgg cgtgagatca tcctctcggc
     9301 tctggtgcgc tcggctgagc aggcgccgtt ctacctgttc acgaccttca tcctctccta
     9361 tggctccaag acactcaaag ttgactccag tgtcctctat gctggcctga ttatctcggc
     9421 agtctgcagc ctgatcctaa tgccgacctg gagccatctc tcagatcgct tcgggcgcaa
     9481 gcgctggtac atgatcggct gcgtcttgat ggccctctac gctttcccgt acttcctgtt
     9541 gctggagacg cgcctgccgg tggtggtcct gctggcgatg atcctctcga tcagcttctg
     9601 ccatgactgg ctctacggtc cgcaggcggc cttgatttcg gagcgctttg gaacgcggct
     9661 gcgctacagc ggggcttcgc tgggctacca gctggcctcg attacggcgg gtggcccagc
     9721 cccaatcctg gcgacctggc tggtagccaa tacgcataca tggctgggga gcgggacgcc
     9781 gtcctatacg ctgattgccg tcttcattat cttcatggcc gtggtctcct tcatctcgac
     9841 agccctgctc gggcgcgaac tggccggtca ggctgccgtg gaggatgtgg gaggtgaaga
     9901 aaccaggcta acgactcagg tgcagtaagt ccggcctgat cagactggct cagcttcctc
     9961 atggagaggg agcgacggag aggcgggtac cgccgcagcc ctatctgcgg agctggccgc
    10021 ctctcctctt gtgcgatccg ctggaggatg gcccgggtgg cgagccagtg ccagagccag
    10081 aggaaatagt gagggatggg agcagcaaga cgtagccctg tgcaatcatg gccgccgtca
    10141 ggaagtagaa cagggcttcc tccaggggaa cattgccgag ggtgaggccc aggatcagcg
    10201 tgggctggaa gaaccagata tgttgagcga tggccaggct atcggtcagg gtcaggtagc
    10261 tgccgaccag aagcaccgcc cagggccagc gtcgacgcca gatccagagc ttgcgccagc
    10321 cgacgagcca ttgcaggccc aggataggca aggcccaggc cagcaggaaa agcagatagg
    10381 tagcgtgcgc catattcgct cagacccctt tcctggtggt aatctcttcc cctgggagag
    10441 gaggcacggg agtgggacca gagcgcagga gggcgtagag cagcaaggta gtcagcaggg
    10501 tttccagcag agcgaagaga tattcttcga ggggaatgag ccagagacgc aggccccagg
    10561 tctgggcggg cgaccagttc cagatgccgc gagcgacggc ggcgtgatcc cagggggcca
    10621 tagccagcag gacgatcgcc gcaagcaggg cagtcgtcag ccagtagcga cggcagagca
    10681 ggcgccggcc cagcagcagt atcagcgagc cgatgggcgc aagcaggaag aggagcagaa
    10741 agccagcgta ggtcattgcc gatttctccc gaagatgcaa gagatgcacc atcataacag
    10801 tagaggcaca ccaggggcga ggaaggtctc tcgccaggcc tctcttctga gtaagacgcg
    10861 tgctgcgcgc ttttctggcc ccaggagaaa cgggctgctg aagccaggag ctggcctcaa
    10921 caggccccgg tgaagtctct gtcttgctct ctctgctcgc tcctgctgcc tatggtacgc
    10981 cgctggtggg tagctgtgca agcgcggcgg gcagctcacg cctccgaacg cctgccgtcg
    11041 tcgaaaggcg agctgcccac ctcctcacgc agcggggggt aggggcaagg gcgcacactg
    11101 ccgcgtgggc gccgtgtgca cgccagcgca gcagcacgcg cgaccccgct gcgtcaagag
    11161 gcgcccgcgt gacccgagct ggctgaggag cgctggctca actcaaggtc ccagcatcac
    11221 cagacgctca accgtcatct cgcggatggc gtaggcgggg ccttccttgc cgaagccgct
    11281 atctttcata ccgccgtagg gcatgccgtc ggcgcgcgta ctggaagtac cattgataat
    11341 cactccaccc acctccagac ggcgagccag ctccagagct gttgccagcg aggaagtgta
    11401 gaccccggcc tgcaagccgt agcggctggc gttggccgcc tcgatcgcct catccagccg
    11461 ctcaaagcgc acaatgctaa ccacaggagc gaagatctct tcacgcgtga tgcgcattgg
    11521 tggcgcgacc tcatgcagca gtgtcggctg aaagagcgtt cctgtacagg tgccgccgac
    11581 cagcacgcgt gcccctgagc gcagagcttc ctccaccaag gcgcaggcgc gcgctgccgc
    11641 gctctcgctg atcagtggcc cgacctctgt cgccggatcg gcggggtcgc cgctcttaag
    11701 ggccgctacc tgcgcgctca ggcgctccac aaactcgcgc tccactgagg tatggacaaa
    11761 gagcgactgg actgacgtgc agacctggcc ggctttgcga tagccggcgt gggccacgtc
    11821 gcgggccgcc cgctccagat cggcatcggc gcagatgatg gtcgctgaga cgctgcccag
    11881 ctccagcgag actggacgca gacccgtctc gcgcttgacg atcgctccca cctcggttga
    11941 accggtgaag gtggtaaagc caatacgcgg atcgcgcagg agccgcagac cgacctcgga
    12001 gccggagcca tagaggacct gcagacggcc ctcgggtagc ccggcctcgt cgaggatctg
    12061 ggccagtagc gcggctgtca gcggcgtcaa ctccgccggc ttaaggatga cggcgttgcc
    12121 ggcggccagg gccggcccga tcttgtgaca gaccgtattg agcggggcat tgaagggcgt
    12181 aatggccagg acgatgccca ctggcacacg gatggtcaag gccagacgct gctcgaagcc
    12241 ggggctggcg tccagaggca ccacttcgcc acccaggcgt agagcctcct gcgcgcagag
    12301 ggtcagcgtg accacggccc gcgcaaattc ctgttcgaca tccttgcgcg agaagcccgt
    12361 ttcgcggcgc atggtctcca gcactgcggt gcggcgctct tcaagcagcg ccaccgcccg
    12421 ctgcaggacc gccgcccgtt cgcgcgccgg ccacgggcgc cgcctggcct gctctgccgc
    12481 ctgcagcgcc tgctcgatct cgcgctcgcc ggcccgcggc agctcgccga tgacctcgcc
    12541 actccacttg tcgcgcacaa taaccgccct ggcggcagcc gatgactgac tcatcgtgct
    12601 catccttcct tcgttccttc tttccttcct agtgctctcc gcgtccgctt tggccgaaac
    12661 cagttgatcc cggctacccg gtgggcgctc tctctgtctc gctgaccagc ccgacaggca
    12721 ggcggacggg cgccgggcga gctggcgacc ggcccggcca gaggggcgaa gcgaagagcg
    12781 agagcggcga actagctggc cctatcaagg gcgcgccgct ctcgggacca ctgaccggcg
    12841 gcccgtccgg cgcggcgtcc aaagaccgag ccggccatca gaccggcacc gcccgggtag
    12901 ttatggtaga agaggccacc gaccagctcg ccggcagcgt acagaccggg cattggcaga
    12961 ttgagccggt ccagtacgcg cccattgggg tcaatgcgta gccccccgaa ggtgaacgta
    13021 ataccgcagg tgaccgcgaa ggcgtagtag ggcggcgtat ccagcggctg ggcccagttt
    13081 gattttctgg gggtgatgcc gaccgtgccc ttgccgtcct tgatggctgg attaaacttc
    13141 acatcgcgca tcaccgcagc gttgaaggtg gtgaccgtct cctccaggcc atcggcatcg
    13201 attcccgcct tctgcgccag ctcgcgaatc gtcagagcct cgaagcgcga gacgccgggg
    13261 gcagtgtact catccttgcg cagaagcggc tcagttttgg catcgaagag ctggaaagcg
    13321 atgccatcgg gttgcttcat gatctcggcg ccatagcgag cgtaggtgta gttgcggaag
    13381 tcggccccct catcgaggaa gcgcttgccc tgactattga ccacaatccc cagcggatag
    13441 gactgcttgg tcagcaggtt ggtcaagaag cgatcaccgt ggggaggagc ggcgacgtcc
    13501 caggccaccg agtgacagcc gctccagtgg ccataggact gcgctcccag cgccagagcg
    13561 gcaaagagga cctcgcccgt attgtagggc gtgccacgca cacgggccag atcccagcca
    13621 ggccccaggt agcaggtacg aagctgcgga ttggcctcga agccgcccgc cgccaggacc
    13681 acggcaccgg cccgaatacg ctgccgctct ctgcctggtg gagagcaaat cacaccgcag
    13741 actgctcccg tcatgtcgca ttccagatca acaaccgggc tgttgaagcg cacctcgatg
    13801 ccgctggctg ccgccgcctg cagatgctgc tcgatcaatc ccttgccgcc gttgaccgtg
    13861 cccagggcca gcccgcccca gaaacggaac tcgccatcaa cctggaacga ctggcgatcg
    13921 tacatcaggc ggaagcgcag tcctttctga tgcagccagc gaatggtctc agcggcctcc
    13981 tgcaccagga tcgccgtcaa ctcaggatca cagcgacctt tggtggtgcg ctgcatatcc
    14041 tgcaggaact gctcaggcgt gtaggggggg agcgcggtcc gctgcagaaa agcctcgtcg
    14101 cgctcgtcca ggagcggcag cagttcctcc agactggaga aggtggtgcg gaaggcgccc
    14161 gctgtgaaat agctgttgcc gcctgcccag tcgctgccgg ccttttccag cactaacacc
    14221 ttgtccacct gctcgcgcgc cgcatgcgca gcgctgaggc cggcgttgcc gccgccgacc
    14281 acgatgacat cgtaatactc tgtcattggc cctccattac cagttgtacc attgcgcgcc
    14341 catcgctctg aatcagtttg gacgtcagac gctggctgat cgccacatga gcgggatgct
    14401 gcatatagcg ctcccaggcc tccatatcgt cgagatcagc caccagcgct acggtgtact
    14461 gttgatcgcg cggactgatg ttgcgcccgg ctaccaggct gcgcaagcct ggcacctgcc
    14521 cgacgagcga gcgccaggcg gcgcacaact cctctagctg ctccggcgtc gcctctgcgc
    14581 gggccttgcc aagaaagata tggcgtatca ccttgctgtg tccctccttt ctcctcgcct
    14641 gccatgaaag gcgctgggag gtggggccgt gatcccccca ccgacctgcc tcgctacatg
    14701 gttagccagc caccatcgac atagagcgtg atccccgtga tataggccga ctcgtcggag
    14761 gccaggaaga ccgccgcccc cgccagatcg ctcggctgcc ccacgcgccc catcggaata
    14821 tgagccagcg ttgccgctaa agattgcgga tcgtccagcc ggtccttgct cagctccgta
    14881 tagatcgggc cggggccgat agcgttgacg cgaatattgg ccttgaccag cgccagggcc
    14941 atcgctttgg tcagggtgcg taccccgcct ttgctggtgc agtaatgcac ggtcgtcggg
    15001 ttgacgctct cggcattgac cgaggcgata ttgatgatca cgccgccgcc ctgctctttc
    15061 atgcggcggg cgaaagcctg cccgcacagg aaggttcctt tcagattgat gtccagcacc
    15121 cgatcccatt cagcttccgt gatctccaga aaatcgtaac gtccgatgac gccggcattg
    15181 ttgaccagaa tatcgacccg cccgaattcg cggaccgtcc aggtggccag ctcattgacc
    15241 tccgtcgcat tggtgacgtc gagatgcttt ccgacaaccc gttgacctgt cgcctgagca
    15301 agctcggcgg cggtctggcg ggctgcctcc tccatgatgt cagcaatcac cacggaagcc
    15361 ccttcgcggg cataggcctc ggcaatggcc cgtccgttgc cgcgcgccgc accagtgatc
    15421 acagcaatgc gctccttcaa acgctctccc atgatggtgt ccaactcctt tctaaagact
    15481 gcttctctcg atggacggcc tgtcgcctgc cacagcgcca ggtggacaga tgaacaggca
    15541 gtcaggcggg aggcggcggg ccgagcctgg agcagccggc ccgctccccg ctggccgtgg
    15601 cactgataga cgtcacatct ccactgcatg ccagcgcggc gacagtcaga cgccagggct
    15661 ggcagattcg tcgggatggt tgatctcatc ctcgcggcgg tcgcgccgct ccagctcgcc
    15721 ggcgggcacc gtcaccacga tgaagagcag gtcctccagg cccgtattgg ccagagaatg
    15781 caccaccccg ggcggaatga aaatggccgt atgcggctca accacatatt ggcgctcgcc
    15841 caggcgcatc aggccacgcc ccttgagaat gtagtagacg tgctcagcct cttcgtggac
    15901 gtgattctcg gcgtagccgc gcggctgata gagcgagagc cgaaaatcaa agtagcgcgt
    15961 ccggctgttg tccgggttca ccagcagctt agagtaggct tcatggtgct gcggcggctc
    16021 gacccagacc agctcttcgg cgcggaccgg gcgcacctcg tcgacctcct tggggatcga
    16081 cgagggccgc ggctcaaagg acggcgaggc actcatagct gatcctcctg ccagccaaaa
    16141 ttgggcagcg ggtggggcag cggtggcagc tcccagctgg ccgtggctgg cggcctgacc
    16201 tcgcgatcga cgcgtacatc gagcaccgtc gggcgcccgc tcgtcagagc ctgatgcagg
    16261 agatcgccca ggtcgccggg acgctcgacc agatagccat cggcccccat agcccgcgcc
    16321 agggccgcaa aatctgccga gaagaggcgc ccgctctgct cctcgacgaa gcttgtcacc
    16381 agctcgcgcc cgctgccaaa gtagccgagc tgctgatcgc ggatcgagca atagccatag
    16441 ttgttccaga ccagccagac caccggaatg gcgtattcaa ctgccgtggc gactgtgccc
    16501 ggccacatca agaagccgcc gtcgccacag acactgacaa cgctgcgctc cggagcggcc
    16561 agcttggccc ccaaagctcc ggcgacgcca aagcccatcg aggcgaaacc gaagctctgc
    16621 aacagggtgc gcgagcgata ggccggaaaa gctgagacca gccagttatg gtgcaccccc
    16681 acatcggaga caacgatagc gtcctcgggc agggcggcgc gcagctcact gatgacgcgc
    16741 tcgggtcgca gagggactgc ctccgagcgg cgcggctcat tgacgtgcgc ctcccatttg
    16801 cgttgccact ccccaatctt ctccagccag ctgcggcgcg ccgcagctct cgtctccaac
    16861 gccgtggtag cacacgctga cagggcctcc agcagctggc gcagcaccgt cctgatgtcg
    16921 ccgacaatac cgactgtcgg ctgatagttt ctgccgatct cgctgggatc gatatcgaca
    16981 tggatcagcc tggtaggcgg aatgcggtaa gtaaagcccg gcagccagga gctggtcgag
    17041 cgatcgtcga agcgtgtccc cagggccaga atgacatcgg cgtggcgggt ggccgcattg
    17101 gccggatagc tcccgttgcg tcctgtggct cccaagctca gccgatggcg cgcatcgatg
    17161 acgcccttgc cgagtggagt ggtgaccacc ggaatcgaca actgctcggc caggcgcagc
    17221 agctccgact cggcctggct tagctcgaca ccgtgtcccg ccacaatcac cgggcgctgg
    17281 gcagagagca agagacgcag ggcttcctgc agatcggcgg gatcagcccc ggcgcgcgaa
    17341 gcaatggggc agtcccatag ctcgcgctca gcctcctcgc gctccacggt ctccacaaag
    17401 acattgagcg gtacatcgag gtggaccggc cccgggcgcc cgctcagcat cagcgtataa
    17461 gcctggcgca gtgccagcgg tagcatgtcg gcccgcgtcg gctgaaagct gcgcttgacg
    17521 taggggcgca gtacgttgac aaactccccc tggaaatagc gaccgctctc ctgaaagggg
    17581 ccacggttcc actgtgaggt gggaacgttg ccagtgatgg ccaggaaggc cgacgaatcc
    17641 atgaaggccg aagcgatcgc cggcaccagg ttggtagagc cggggccgca ggatgtgaaa
    17701 gtcgcaaccg gcctctgggc cacgcggaag taggcgtcgg ccatgaaggc ggcgcaggcc
    17761 tcatggtgca cagagatagc tttcagctcg tcccggcggt catagacggc atccagaaag
    17821 ccgaggatgc cgtgaccaca gagaccaaag acatagggga cgccgcgcct gatcagaaaa
    17881 tcaacgatca gttccgcccc cttgatcgct gccattgata atcaaccctc ctcctgctga
    17941 tggaatgatg aactgccggc tgctctgctg cggctggggt gctcgctcag acgcgctcgg
    18001 ccggttctgc ttcaatcagg ccggggcctt agctgctcgc cattgggctg gcccgcccga
    18061 cgtaggactc taccaggcgt gggtcatgca gcagctcggc ggcgggggcc acgcgcgtaa
    18121 tgtggccatc ctcgaagaca tagccacgct gggcgaagcg cagggccgcg taggcattct
    18181 gctcgaccac aaagaccgtc aggccgccgg catgtaaggc ccgcagggcc tggtacagct
    18241 cgccaaccac ccgcggggcc agaccggtcg atggctcgtc aaggatcagc agccgcggat
    18301 gggtcatcaa agcccgtcca accgtgacca tctgctgctc gccaccggag agcagtcgac
    18361 agcgagtctg gcgcaggcgc tgcagcttgg gaaagatctg gtagatgtag gccaggcgct
    18421 ggcgaaggtc agccctgctg gcgcggtagg cgccaatctc caggttctcc tcgacggtca
    18481 tctcgggaaa gagtgcgcgc ccctcgggta cgtaaccgat gcccaggcgt acgcgctcaa
    18541 aaggtggcag gcgggccaga tcgcgacctg caaagaagac ctggccgccg ctcagcggca
    18601 gctggcccat gatcaggcgc agcagggtcg tcttgccagc tccattggcg ccgaccgcgg
    18661 ccactgcctc gccctcggcg atgctcagac tgacctcatg gacgacggtg cgaccatgat
    18721 agccgcccga gacctgctgt aactgaagca actcaggcat tgaccggcgc ctcctctccc
    18781 gtgcccaggt aggcctcgat caccgcggga ttgcgcagaa cttcgtcagg gcggccctgg
    18841 gcgatagtgg tgccgaagtc gagtacatag acatgatcgg caatgggcat aatggcgggc
    18901 accacatgct caatcgccac tacggcgcag cccgccgcta ccgcctcgcg cagcagcgca
    18961 tgcacgagat ggatctcctc gggcgacatc ccggccatca cctcatcgag gagcaacacg
    19021 cgcggacgca gcatcaaggc ccgtccgatc tccaggaaac ggagctgacc cggcggcagg
    19081 ccctcgggcg aggcatccca ctgctcgcgc agggccaggc gctctagcat ctgggtagcc
    19141 gtcctgatgg tctcctcctt cgggatgccc gccgccagag ccggcaacag cagggtctcc
    19201 caggccgtca acgaagggaa aggccgacag gtctggaagg tacgcgcgat gccggcccgc
    19261 gcaatgcgat agggagccag acggttgagg agcgtctcac caaagcgaat ggtcccgccg
    19321 ttgcagcggt cgaagcccgt gatcaggtta aagagggtgg tcttgccggc cccgttggga
    19381 ccaatcacgg cgacgatctg cccgctgcga gcttccagat tgacccggtt gagggctgtc
    19441 aggccaccga agcgccgggt aatctcctcg cagcgcagcg ccggctctcc tgtcctgctg
    19501 accgcggcgg ggaaaagtgc ccgccgcgcc tcagcctcta tcattggagg cggcccccat
    19561 accggacggc gtcgcagcca gccgaaacgc tggaagagcg agaccaggcc gcccggcatc
    19621 cagagcacgg cgatcaagat caaggccccc agaataattt gctgctgctg tgggaactgg
    19681 gcccagaggg cattgctgat caacgaaatg accactgcgc ccagcagcgg cccccagagc
    19741 gtgccaatcc cgccgaagag caccatcagg atcgtctgca gctcataggt gttgttgaag
    19801 gcgctgccgg gatcgatgaa gcccacgttc cacacataga gcgcgcccgc cagggcggcc
    19861 aggccggcgc tcaggcagaa agccaccacc ttgctcgcgt tggtattgat ccccgaagcc
    19921 tcggcggcct tctcgtcgtc gcgcaaggcc agcaggcgta gccccagcgg cgaacgcagc
    19981 agccaggccg tcagcagaac ggaccccact gcgcaggcca gcatgaccag ggcggtctcc
    20041 tgggtgctac ccacgatggg cactggctcg cccatgctcc cgcctaccag tggcgtcgag
    20101 gtggcgatca aggccccgat gtggctcagc ccgaacatcc ccagggcgaa aaagatgccc
    20161 tgcaggcgca gcatcaccgt ccccagcggc agggccagga gcactgccgc caggaccgcc
    20221 cccagcgccg ccaggtacca atcccactgc caggcgatct ggcaggttgc ggccacatag
    20281 gccccgatgc cgaagaagcc cacctggccg aaggagacgt agccgctcag cccgctgata
    20341 atattccagg cataggccag gaccacgaac aggcaggtgg agaagaggag ctgggcctga
    20401 tcgccgttcc cgaagagcgc aatcagaacc ccggcaacga cggccacccc gaaaatcagc
    20461 caggcgcctt cttgcttgaa gagtcctgtg gctcgccacc cgggaaaggt cggcctgatg
    20521 tgcctccgtc tcatatgcgc cccctttggc caagcaggcc ctgcggtcgc acaatcagca
    20581 ccagaataaa gatcacgtag atcaccgctg aggcggcgct ggcgcccaga aagtagctgc
    20641 tgctcacctc gatcactccc aggagaatgg cggccaggag ggcgcccagg taattgccga
    20701 ggccaccgag ggcgatcagg gtaaaagcct ggaccgtcat gaagccgcca gaagca
//
