LOCUS       NZ_MCIF01000002        20963 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Thermogemmatispora tikiterensis strain T81 A4R35_scaffold00002,
            whole genome shotgun sequence.
ACCESSION   NZ_MCIF01000002
VERSION     NZ_MCIF01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Thermogemmatispora tikiterensis
  ORGANISM  Thermogemmatispora tikiterensis
            Bacteria; Bacillati; Chloroflexota; Ktedonobacteria;
            Thermogemmatisporales; Thermogemmatisporaceae; Thermogemmatispora.
REFERENCE   1  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Analysis of Carbohydrate Active Enzymes in Thermogemmatispora T81
            Reveals Carbohydrate Degradation Ability
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-AUG-2016) Faculty of Agricultural and Food Sciences,
            University of Manitoba, 66 Chancellor's Circle, Winnipeg, Manitoba
            R3T 5V6, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2011
            Assembly Method                   :: Newbler v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 25.9x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003268475.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 03:19:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,660
            CDSs (total)                      :: 4,607
            Genes (coding)                    :: 4,541
            CDSs (with protein)               :: 4,541
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 8 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 6 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:11:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4647903
            Orig. end                         :: 4668866
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MCIF01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20963
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20963
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20963
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10963](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10963
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(261..271)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            2295..2582
                     /locus_tag="A4R35_RS18655"
                     /old_locus_tag="A4R35_18530"
     CDS             2295..2582
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS18655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_18530"
                     /product="hypothetical protein"
                     /protein_id="WP_112432000.1"
                     /transl_table=11
                     /translation="MEPSKRIEEYRERYDPRQLMRALRESLDERGRLRLLAGAGGYRWE
                     AGFRFGEPASEEELEELEARLTGERCRSYRQAETPVERSTLPGGESFTVY"
     misc_feature    complement(2614..2626)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(2819..2832)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.68"
                     /tool="antismash"
     misc_feature    2820..2833
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 20.32"
                     /tool="antismash"
     misc_feature    complement(2820..2835)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.31"
                     /tool="antismash"
     misc_feature    complement(2835..2852)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.95"
                     /tool="antismash"
     gene            2887..3558
                     /locus_tag="A4R35_RS18660"
                     /old_locus_tag="A4R35_18535"
     CDS             2887..3558
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014952318.1"
                     /locus_tag="A4R35_RS18660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18535"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_112432002.1"
                     /transl_table=11
                     /translation="MKKPARRGAHREQPHSARAREEESEETRRLILQVAQQLFMEYGYR
                     AVTTRQIADACGLTQPALYHYFADKEALYLAMAREELARLKAVLERIARRSEPLAERLR
                     RLASYLLTTTRHDLALMLHDIRYELSAEVRAQLHTLFEESLIAPIATVFSDGLEQGLLR
                     SPSEGGVDPKMAAYLFMSLMSRFVVWGRETLPAVAESRRETLASEQAALLVHVLLYGLA
                     R"
     gene            3618..5312
                     /locus_tag="A4R35_RS18665"
                     /old_locus_tag="A4R35_18540"
     CDS             3618..5312
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="A4R35_RS18665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18540"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_112432004.1"
                     /transl_table=11
                     /translation="MESDMTLGGQSQPEEQRQASTAPAAPAEVAPADPNYRWKVLFSVV
                     FGTFMVILDATAVNVALPTLQHVFKAPVDQVDGVLTAYVLALGIITPLAGYLAERFGIK
                     RMYLISLFLFVLGSVLCAFAPSLPWLVAFRALQGLGGGMLGPLGISLLFGAFPEKQRGL
                     AFGLYGIPLVVAPASGPVLGGYFVEYLDWRYIFFINIPVGLAGLLLGFFWLRESRRGTA
                     ARLDLPGILLSVISFGTLLYAIQRGSSEGWTSARILTLLSVGLLTFAVFVVVELFRRDP
                     LLDLRLFTRRTFTVASVIGWVSTIALFGAEFLLPIYLQSLRGRTPLQAGLLVLPLAISS
                     GIVTPLAGALYNRIGPRWLILAGSLLLAVNTWGFAHLTLVASYNEIMVLVAIRGVALGL
                     TLQTTLTVALTGLKPAQLPRASSLLNATRNVFQSFGIAMLGTIVTHQLTAYQDAARNDL
                     YNAATSLGQRFLQLVQVLQMRGLPAAAAQKAAAGQLLGSLVPQQFMQSINDAYIVTFWL
                     ALAVAVLALTLPGRTRLATARAAAEEGAGPASASAPAAAPASGAQGS"
     misc_feature    3630..3645
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            complement(5309..5998)
                     /locus_tag="A4R35_RS18670"
                     /old_locus_tag="A4R35_18545"
     CDS             complement(5309..5998)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016119.5"
                     /locus_tag="A4R35_RS18670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18545"
                     /product="class F sortase"
                     /protein_id="WP_189362024.1"
                     /transl_table=11
                     /translation="MQGKAKPTHHDPGQPGFGSGGVRHWLLLLLPILLVSSGLLVTGCG
                     AVSPPVVDGGQGVERQPPAPVTATATAPATVLSPAPPTQLLIPAIGVAAPVERVGLGAD
                     GTLVTPQRHPWDDVGWYRFGPLPGQQGSAVIAGHLDRPGGYPAVFWNLHLLRPGTTLTV
                     IDERGQRWHFRVTAVASYPPQRAPLLQIFADRSGHYLNLITCAGSWVPSEHQTTERLVV
                     YSVLQGS"
     gene            complement(6168..7016)
                     /locus_tag="A4R35_RS18675"
                     /old_locus_tag="A4R35_18550"
     CDS             complement(6168..7016)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025702.5"
                     /locus_tag="A4R35_RS18675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18550"
                     /product="DUF4397 domain-containing protein"
                     /protein_id="WP_112432008.1"
                     /transl_table=11
                     /translation="MRSKTLLAFVKAVSIFSAALALILWLLPVGQAAAQGNALVRVVHA
                     SPAAGNVDVFVDGGKLLSNFAFGTVTDYVSVAAGPHRIQVAPAGKGIDAAVINETVSVD
                     ADMAYTVAAIGDSAANLGLQAFVDNNQLSSGMAKVRVYHLSPNAGPVDIATGGKTVISG
                     LTYKNASDYLSVPPGSYTFNVTATQANATVPVSATLQSGMVYSVFAVGLYKGTPELKFV
                     VAAVSGVPGMPNTGSDPNAMPQSMATPTAQLWLFGLISLLALAGLGIGAREIVGRRRRS
                     A"
     misc_feature    complement(7006..7019)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    complement(7215..7227)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            7427..8176
                     /locus_tag="A4R35_RS18680"
                     /old_locus_tag="A4R35_18555"
     CDS             7427..8176
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="A4R35_RS18680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18555"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_189362026.1"
                     /transl_table=11
                     /translation="MERDSRWRSPAGETGSEGVEAPSQAERANRADSTENARDSSWEKE
                     LVARCLTGDEEAFARIVDTYGGLLLRTAYLLIKDEEGAKDLVQETFFLAWKNMTTLRDP
                     ALLRSWLLKILVNQAISLKRQLARQATLLRERLAGEEQEQLLPKTSLREGRVEDWLDVV
                     AALQRLPVKQRVVLVLFYYHRLTMPEIAAMLGVAENTLRKRLQLALKKMRRLLQIRPQE
                     RPAAQEEAAGADQPPSQIASGREEQHE"
     gene            8169..9530
                     /locus_tag="A4R35_RS18685"
                     /old_locus_tag="A4R35_18560"
     CDS             8169..9530
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS18685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_18560"
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_112432013.1"
                     /transl_table=11
                     /translation="MSDAPHEPQPSEELPTGQPARSAERRGWQGAEEREQVNHRAPVDD
                     VLLEEVIRRALQEQAARIHFSPELRARILSGLPPRTSERRSQLSRRSRLALALAATLTL
                     LLCLVLLLLLFLPQAPSGPPLANGVRYQVAQVLAVPPALAQGGRLVAVDPTGRHLVIQD
                     GRDPGVMYTASLSDPVGSQLLAMREAHDAAWSPDGTALVTVVTPPGAAQPLLALVPYGQ
                     YMYPLGEAALAATWTPGAGSTTITYVTGANGQTQLWQTTRGGHPTQLLATMNLRLTVQH
                     LAWSPDGRYLALLVSNEGLNGPGRAIYLMDHVSGQVTVLVPFGDFTITSFGWSPDGQRL
                     TYARRDAAGHTLLTTLAIPDGRPLLSLPLQGELDGWSWSPDGRALVYSDDGRLHVHIFA
                     GSPIVLPQPEAGARQLFPFWLRDGRLLIVHVAASGQRTLQLLAPVPAAPRSPSA"
     gene            10001..10963
                     /locus_tag="A4R35_RS18690"
                     /old_locus_tag="A4R35_18565"
     CDS             10001..10963
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012705.5"
                     /locus_tag="A4R35_RS18690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18565"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_189362028.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.8e-69, bitscore:
                     231.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.2e-65,
                     bitscore: 219.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASSLCSVPAAAASEAQEEALLAHHGRTFHFAARFLPGELRPSF
                     VTLYAFFRTLDDLVDERRPEEEPRAIAEELRAWRAWFLADRQGTAPREPLGSRLTQVVE
                     RYGVPGTLFLDFLEGLHWDLWPREFASFSRLRAYCYRVAGTVGLALAHVLGATSGGALA
                     AAEGLGIAMQLTNILRDVGGDLRKGRLYLPLEDLARFGLSRSHLLQLLDTGQGPDAAFR
                     DLMRYEVTRTHLCYAQSLPGVWLLPPDRRLPILLAGRLYRRILHAIEQHDYDVLRARAH
                     TTLTEKLREAMLALTLDRLWRRGEQLGAFGLEVSLEDEP"
     gene            10953..12191
                     /locus_tag="A4R35_RS18695"
                     /old_locus_tag="A4R35_18570"
     CDS             10953..12191
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025025.5"
                     /locus_tag="A4R35_RS18695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18570"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_112432017.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.3e-12,
                     bitscore: 45.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRKLLWMGWLGAFSAGQLVLALRVILRWLRSTGGQRLSALSLPH
                     ADAATQASVAVLVPVLNERERLSPCLEGLLTQGPEVGLILVIDGGSEDGTDELVSAYAR
                     RDRRLRLLSAAPIPDGWNGKVWGLEAGWRALPSTFPWVLTIDADVRPGPGLVSALLARA
                     SRDRLAALSLATEQELPPAPLLGLLHPSLLATLVYRYGLPGVVYEGPVDRLRVQANGQC
                     FLVQREALAACGGFAPLRHSLCEDITLARLLVQDGRRLAFVEGGSLASVEMYRTAREAW
                     QNWTRSLPLHDHLSPAWRTCLGWLEVLLVQALPLPLLSLLAGALIAGRRRWRQASLWLL
                     VAMLGLNAGLLLLRLGTLVGMRRAYRRPPWTYWLSPLCDLAVTLQLGRQALRRRHRWRG
                     RLIIRGNAPGGIA"
     gene            12188..13909
                     /locus_tag="A4R35_RS18700"
                     /old_locus_tag="A4R35_18575"
     CDS             12188..13909
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016155.5"
                     /locus_tag="A4R35_RS18700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18575"
                     /product="carotenoid biosynthesis protein"
                     /protein_id="WP_112432020.1"
                     /transl_table=11
                     /translation="MKAVKVLFICHLAALIFGLAGLLIALPHPELWSFSPLLVSVFSFG
                     INYAGSLHILFGAATVLLFGLRVVGVRRTLIFFAASTLISLSIELLGTSTGFPFGPYSY
                     NSFLGFKILDHVPYSIPLSWFYMGFSSFLLAHLLLTRRGQGVGQRGRGLWTVLLGAYLL
                     TVWDLTLDPAMASERLPLHFWQWGVSGAYFGMPVQNLVGWSVTGLLYMGVSRLLWRSDL
                     EERRLQGVAWLPFGVYAANTLFAIVLDLSVGLWLPPLLGLLLGILPAALVLRRDGSEGG
                     ERGSGRPVPTLSERAELAPDLAQAQQGSRGLEAQSRAEGQALLQRIARLVMRVGAGILL
                     WRRRLRIIVEGREHLPAYGPVIVAARHYHHLYDGCLFLRVIPRPVHILVALDWARSRWQ
                     RRLMELLCALAGWPVILRPERLRPEETGASVSAYRLGEVAPYLRRALRQARTLLCRGDL
                     LVIFPEGYPVVDPQPSPRSPEQALLPFRPGLARLVELAERASGTSIPVVPAGIIWSETR
                     PPLLTLRLGAPLFRRLYADTAQFMSALESCVRALSGLDHDQGLSLSLFPGKEMLHS"
     gene            13906..15456
                     /gene="crtI"
                     /locus_tag="A4R35_RS18705"
                     /old_locus_tag="A4R35_18580"
     CDS             13906..15456
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012455069.1"
                     /locus_tag="A4R35_RS18705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18580"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_112432022.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 7.6e-07, bitscore:
                     26.7, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 9.2e-11, bitscore: 40.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSRSSVTSAANRLPAGGSGVRPRVIVIGAGFGGLAAAIRLQAAG
                     AQVILIEARSQPGGRAYQLKAEGFTFDMGPSLLTAPWLLQDLWQAAGRHLDEDVTLVPL
                     RPFYRIGFADGNHFDYWGDPAADEAEIARFDARDVAGYRAFLAATERIYQRAFAELAGE
                     PFLRLSDFLRVAPELVRLGAHRSVYRFVSRYFRHPQLRMVFSFHPLFIGGNPFRASAIY
                     SIVPYLERLGGVHFIPGGMYALVEAMTRLFTALGGELRCGQPVERILVRSGQVWGVLLA
                     DGALLQAEAVVANSDVATTYLRLLPAEVRPRGLVRRLERAHYSMSCFLLYLGLKRQYPQ
                     LRHHSIFMPHDYRGLIRQLFDGQGLPADLALYLHTPTRTDATLAPPGGESLYVLAPVPH
                     LGHGVDWQRETLPFRERILRYLEEQAGLHGLRASIVYEQRFTPLDFADELRSHLGAAFS
                     LEPTLFQSAYFRPHNRAAQVGGLYFVGAGTHPGAGIPGVLLSAAITARLVREDLACRA"
     gene            15509..16432
                     /gene="uvsE"
                     /locus_tag="A4R35_RS18710"
                     /old_locus_tag="A4R35_18585"
     CDS             15509..16432
                     /GO_function="GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0009650 - UV protection [Evidence IEA]"
                     /codon_start=1
                     /gene="uvsE"
                     /inference="COORDINATES: protein motif:HMM:TIGR00629.1"
                     /locus_tag="A4R35_RS18710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18585"
                     /product="UV DNA damage repair endonuclease UvsE"
                     /protein_id="WP_112432024.1"
                     /transl_table=11
                     /translation="MRLGYACVNLSLGGKMRSLRLATLRERGLAYLQALVDENLALLVA
                     ILRWNLAQGISVFRISSDLVPLGSHPEVALEQIRFDPARVAEVRQLARAGRMRLSMHPG
                     QYTLISADGPVWKSSYRDLCYHAEVMERLGLEGDIILHGGGVYGDRAATLRRILTHIDE
                     LPESVRRRLRLENDERCWSVSQLLPICEASGLPLVVDNLHHTLNGGAETPLERLPWERI
                     LTTWGRLRPKLHYAEQDPGKRPGAHSEYINADRFRAFLTAVPWSDYDVMLECKAKDLAL
                     LRLRQELGLIAAGPLPGAGEGSDHQG"
     gene            16537..17841
                     /locus_tag="A4R35_RS18715"
                     /old_locus_tag="A4R35_18590"
     CDS             16537..17841
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013177184.1"
                     /locus_tag="A4R35_RS18715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18590"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_189362030.1"
                     /sec_met_domain="DAO (E-value: 5.6e-13, bitscore: 47.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIVVGAGLAGLTCARHLSRAGLSVLVLEAGDRPGGRVSTDRHPE
                     GFLLDRGFQVLFTAYPAVQRELDLAALRPRRFLPGALLVKGGRRYPLADPRRQPGWLTA
                     SASNPLIPLTDKWRVLRLTRTILQTVSVESPAAWPVATLDETSELYLRHWGFSRKGFIA
                     HFARPFFGGIFLDRELQTSARMLRFVWRMLASGDIVLPEQGMGAITAQLAASLPENSLR
                     LGARVEALLREDGRVSGVRLESGEELRAEAVVIATDSPTAARLTGLSLPTAGRGCTCLY
                     FAGPQPLYDEPALLLNCQPDGLVNHAVQLTNIVPQYAPSGQHLLSVTILDAAAQAEEDD
                     ERLAQRALQELASWFPEHDLQRWRLLAVYRLPFAQFAQPPGIFAHLPGARSGEPGLYLT
                     GEYLHSSSIHGALSSGAHTARLVLADQREWLRPAG"
     misc_feature    16540..16554
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            17861..18358
                     /locus_tag="A4R35_RS18720"
                     /old_locus_tag="A4R35_18595"
     CDS             17861..18358
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS18720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_18595"
                     /product="hypothetical protein"
                     /protein_id="WP_112432028.1"
                     /transl_table=11
                     /translation="MQELVERRPPTWRPGRAALAGLLATGVYSLVMALDQRLSGNHFSD
                     VRFIEGLLGGGTRQPDGRRLLAWGLHLLNGVLLGEIYAALVRPRLPGPIWLKGLLFGEG
                     FLASVWWLTPLADRVHPLIRRGQLPRLATWSSFGQNLLRHLAFGLTLALFYGDERELPP
                     RP"
     gene            18527..19309
                     /locus_tag="A4R35_RS18725"
                     /old_locus_tag="A4R35_18600"
     CDS             18527..19309
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025049.5"
                     /locus_tag="A4R35_RS18725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18600"
                     /product="ferritin-like domain-containing protein"
                     /protein_id="WP_112432030.1"
                     /transl_table=11
                     /translation="MKTYINRSSSRKQQGRRRFLQRATAGLGLATGGLTLLGSGARPLV
                     VRAQGALTERLVTLDDAVTQILSIARTAEQLAVTFYSNGIANAEALGISGDDLAYLKAA
                     LVEEQIHQQFFTANGGQSLADTFSFPKGSQTFSDLKTFIETQQQLEGVFDSAFLAAIKE
                     FAAMGRPDLAQVAGQIACIEAEHRALGRVIGGLRPADNWAFTPVLIASVADAPQVVQDA
                     GYLSPTEGNSYRYHEVSTEDAGVEQRVPFVASSGVGRG"
     gene            complement(19652..20611)
                     /locus_tag="A4R35_RS18730"
                     /old_locus_tag="A4R35_18605"
     CDS             complement(19652..20611)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012372984.1"
                     /locus_tag="A4R35_RS18730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_18605"
                     /product="aldo/keto reductase"
                     /protein_id="WP_112432032.1"
                     /transl_table=11
                     /translation="MEYRTLGRTGLKVSRLCLGTMQWGWTVDEPTAFAIMDAFVERGGN
                     FFDTADFYARWIPGKRGGESEEIIGRWLRARGNRSQVVIATKVYHPMGEGPNERGLSRK
                     HIIEAVEASLRRLQTDYLDLYLAHAFDAETPIEETLRAFDDLQRSGKVRYIGASNYPAW
                     RLVEALWCARYECTARYEVLEPHYNLVHRAEFEQELQTICLQYGLGVIPYSPLASGFLG
                     GSYRRGEGRQSARAAAVLGRYDQEQAWRTLEAVQAVAEETQATPAAVALAWLLAQPAVT
                     APIIGASQPAHLEDGFAALGLQLTPEQLARLSAASQGL"
     misc_feature    complement(20738..20752)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
ORIGIN
        1 agacgcagct gcggttgctg gagcgggcgg gggtacaggg atggatggtg ccgggactca
       61 tcggggtgat gaagcattac ccgggggcgg aggagttgga gcgagcgaga cggctgttga
      121 gggagctgcc gaaggaggag cggagggggt atcgagggct gctcgaaggg gtgggggagg
      181 gtgagcttgt cggggtgagc tctgaagagc gaggggggaa tgagggagcg gaaggggggg
      241 actggcagga ggagttgctg gtgagattgc aggaggtggt acgaggaccg agagggtctg
      301 gggaggagag ggaggtggag gagatagcga gagagctggg ggctgtgggg agggagagag
      361 gggcgggact ggtgtatgtc ggggtggtgt gggagttgga ggaggagagg atgagagagg
      421 gggagccagt ggcggagcag gaggggcgag ggggtcggga gctggggggg tggttgaggg
      481 tgctggagcg agtgggagtg gagccgtgga tggcgccagc gttggtggag gtcgtgagga
      541 ggtatcggca gagggaggag ggagagctgg cgcgggggtt gctgggaggg ctgccgaagg
      601 aggagctgag gcgctatcgg gaggtgctgc ggttgatggg gctgggggag ctggcggacg
      661 aggaggaggc tccttggtca gcgggggggc ggtgggaagg ggtggcagag cggaggcagg
      721 aagaggagag ggccaggagg aggaaagggg aggagtgggg agagctggga gcgctggtgg
      781 aagactatgt ggaggcctat ggtgagtggt ggtggcatgg cggtgagcgg gagaagggga
      841 ggttgcagga gctgaaggag cgccttcggg aggaggggga gcgggcggtg gaggtgctgg
      901 cggcattgct gggggaccgg acccagacgg agaggatgac cccgatcttg gtgctgttgc
      961 aggaactggg gtatccgtgg aatgcgaagg cgctggcggg ggtgctgcgt ctggtgggag
     1021 atcccgagca tgagcgtagc gtgtttaccc tcttgtgggg ggtcccggtg gaggagctac
     1081 tcccgcagct gctggcggcg ctgctggtgc cggggcgccc gtatcattgg gagggagatg
     1141 agcgggaggt gggagaggcg gcaggctgtg ggctgtcgag ctatgactac tgggtgctgg
     1201 atgtgtatgg ggggctggcg ggatggctga gggagccgga gacggagcgg gagctggtgg
     1261 agcgatgtgg gccagtggcc ttctacttgt tgagctatga agtggagcag tggcgcagga
     1321 ggcgggtgga gagagaggac caaagggtgg cggaggacgg gtctgcgggg gtggaagggt
     1381 ggctgagggt gctggagaga gcgggggtgc agccgtggat ggcgccagcg ttggtggagg
     1441 tggcgaggca gtggccgaag gcgtggaagg gggaggtagc gcggcagttg ctggggaggc
     1501 tgccgaagga ggagctgagg ccgtatgggt tgctcttgcg gcgggcggga ctgggggagc
     1561 tggtcgggag gcaggagcag gagccaggag ggcaggaggc tgagcggctg tggaagctgg
     1621 agagcggggt ggaggaggag ggcgaggagg tgagggagga gctgcggggg atcgccgggg
     1681 aggagcaggt gccctacgtg gtggaggcgt tgctggagcc agagggggct ggcgaggaga
     1741 gaaggaggga gcagataggg aggctgctgg agcgagggga gctggaggac agtgtggtgg
     1801 agggatgcag ggcggtggtg tactatctgc tggcgtggga gctggaagag cggaggagga
     1861 gggagctgga cccgctggcg caggaggagg agcagcaggg aagggagagg tggtcgagaa
     1921 cagtactgga gcgagagagt gtgctgtggc tgagggtgct ggagcgggca ggggtcgagt
     1981 cgtggatggc gccgggcttg gtggaggttg tgaggaggta cccgcagagg gaagagggag
     2041 aagtggcgcg gcggttgcta ggaaggctgc cgaaggagga gctgaggcgc tatcgactga
     2101 tcctggagca gagtgagctg ggggagctgg ggagctgaag gggtagagga gcggtgatca
     2161 gggaggcaga accgttttgg gagagggcgg caagaaagaa tttcgagagt gccgaggggt
     2221 ggcctgcgtc aggagagtcc ggggagctac ggggcagaag agcggatcag aagcgaagca
     2281 gcaggaggag agtgatggag ccgagcaagc ggattgagga gtatcgcgag cggtatgatc
     2341 cgaggcagct gatgcgagcg ctgcgggaga gcctggacga gcgagggcgg ctgcgactcc
     2401 tagcaggggc agggggttac cgctgggaag cgggctttcg ctttggagag ccagccagcg
     2461 aggaggagct ggaggagctg gaagcgagac tgaccggcga gaggtgccgc agctacaggc
     2521 aggcagagac gccagttgag cggagcacac tccctggagg tgagagtttt accgtctact
     2581 gacgaaggtg gagcagagca ggcagagaag acggtgaaag cggcacgagc aaaacagcgc
     2641 cctctcttgc ttgcaactgg tgtctcatcc ctcatcgagc catccgctga ccccgtagcc
     2701 acagaaggag ctgctttccc atcctcatga tagcgcgatg atcagcgtgg acaatagcga
     2761 actatgacct ctttccttgt ctgccttgac ctgcccttga ctttctccct cttgcgggat
     2821 ataatcctta tcagttgata aggaaataac atcatcgaga aaggcacagc caggtaacgg
     2881 gccagcatga aaaagccagc gcggcgcggc gcccacagag agcagccgca cagtgccaga
     2941 gccagagaag aagagagcga agagacccgg cgcctcatcc tgcaggtcgc ccaacagctc
     3001 tttatggaat acggctatcg ggccgtcacc acgcggcaga tcgccgatgc ctgcggcctg
     3061 acgcagccag ctctctatca ctactttgcc gacaaagagg ccctctatct ggcgatggct
     3121 cgtgaagagc tggcccgcct caaagcggtc ctggagcgca tcgctcgccg cagcgagcct
     3181 ctagccgagc gcctgcgccg cctcgccagc tatctgctca cgacgacccg ccacgacctg
     3241 gcgctgatgc tacacgatat ccgctacgag ctctcagccg aggtgcgcgc gcagctccac
     3301 acccttttcg aagagagcct gatcgcaccc atcgccacag tcttcagcga cggtctggag
     3361 cagggcctgc tgcgctcgcc cagcgaaggc ggcgtcgatc ccaagatggc cgcctatctc
     3421 tttatgagcc tgatgtcgcg cttcgtcgtc tggggacgcg aaaccctgcc cgccgtggcc
     3481 gagagccgtc gcgagaccct cgccagcgag caggccgccc tgctcgtgca cgtcctcctc
     3541 tacggcctgg cacgctgagc gtcctctttt tttgtcgcaa gaatttatca cttgataagt
     3601 agaaggaggt ctccacaatg gagtccgata tgaccctggg gggtcagtca cagccagaag
     3661 agcagcggca ggcatcgaca gcacccgccg cgcccgctga agtggctccg gctgacccaa
     3721 actatcgctg gaaagtcctt ttctcggtcg tcttcggcac cttcatggtg attctggatg
     3781 ccactgccgt caatgtagct ctgcccaccc tccagcatgt ctttaaggcg cccgttgacc
     3841 aggttgacgg cgtccttacg gcctatgtcc tggccctggg catcatcaca cctttggccg
     3901 gctacctggc cgagcgcttc ggcatcaagc gcatgtacct gatctcgctc tttctcttcg
     3961 tgctcggctc ggtactctgt gccttcgccc cctcgctgcc gtggctggta gccttccgcg
     4021 ccctgcaagg actgggtggt ggcatgcttg gccctctggg catctcgctc ctctttgggg
     4081 ctttcccgga aaagcagcgc ggcctggcct ttggcctcta cggcatcccg ctggttgtcg
     4141 ctccggccag cggtcccgtg ctcggtggct actttgtgga gtacctcgac tggcgctaca
     4201 tcttcttcat caatatcccg gtcggcttgg ccggcctgct gctcggcttc ttctggctgc
     4261 gcgaaagccg gcgcggcacc gccgcccgtc tcgacctgcc tggcattctg ctctcggtga
     4321 tcagctttgg caccctgctc tacgcgatcc agcgcggctc aagcgaaggc tggacctcgg
     4381 cccgtatcct gaccctgctc tccgtcggtc tgctgacctt cgccgtcttt gtggtcgtag
     4441 agctattccg gcgcgatccc ctgctcgatc tgcgcctctt cacgcgccgc acctttacgg
     4501 tggccagcgt catcggctgg gtgagcacca tcgccctctt cggcgccgag ttcctgctgc
     4561 cgatctacct ccagagcctg cgcggacgca cacccctgca ggccggcctg ctggtcctgc
     4621 cgctggccat cagctcggga atcgtcaccc ccctggccgg cgcgctctac aaccgcatcg
     4681 gtccgcgctg gctgatcctg gccggcagcc tgcttctggc ggtcaacacc tggggcttcg
     4741 ctcatctgac gctggttgcc tcctataacg agatcatggt gctggtggct attcgcggcg
     4801 tggccctcgg tttaacactg cagacgacac tgaccgtggc cctgactggt ctcaagccgg
     4861 cccagctacc gcgagccagc tcgctcctca atgccacgcg caacgtcttt cagtcctttg
     4921 gcatcgctat gctgggtacc atcgttaccc atcagctcac ggcttatcag gatgcagccc
     4981 gcaatgactt gtataacgcg gccacttccc tgggtcagcg cttcctgcag ctcgtacagg
     5041 tgctgcaaat gcgtggcctg ccggcagcag cagcccagaa ggccgccgcc gggcagctgc
     5101 tcggctcact ggtgccacag cagttcatgc agagcatcaa cgacgcctat attgtgacct
     5161 tctggctggc gctggcggtt gctgtcctgg ccttgaccct gcctggacgg acgcgtctgg
     5221 ccacggcccg ggctgctgct gaggaagggg ccggtccagc ctcggcctcg gcccctgccg
     5281 cagcaccggc cagcggtgcc cagggaagct agcttccctg gagcacactg tagacaacca
     5341 ggcgctccgt tgtctggtgc tcgctgggaa cccaggagcc ggcgcaggtg atcagattca
     5401 gatagtgccc cgagcgatca gcgaaaatct gcagcagcgg cgcccgctgg ggtggataag
     5461 aggcgacggc agtgacgcga aagtgccagc gctgcccgcg ctcgtcaatg acggtaaggg
     5521 tcgttcctgg ccgtagcagg tgcaggttcc agaagaccgc tgggtagccg ccgggccggt
     5581 cgagatgtcc cgctatcact gcgcttcctt gctgccctgg caaaggcccg aagcgatacc
     5641 agccgacatc atcccaggga tgccgttggg gcgtgaccag cgtcccgtcg gcacccaggc
     5701 cgacgcgctc gacaggagcc gctacgccaa tcgctggaat gaggagctgg gtcggcggtg
     5761 ccgggctgag caccgtggca ggagctgtcg ctgtcgccgt caccggagcc ggaggctggc
     5821 gctccacgcc ttggccccca tccactactg gcggactgac cgcgccacaa cctgtcacta
     5881 gcagcccact gctgaccagc aggattggca gcagcaagag cagccagtgg cgcacaccgc
     5941 cactaccaaa acctggctgg ccggggtcgt gatgtgtagg ctttgccttt ccttgcacag
     6001 accaggctcc ttcgtagaga agaggcgggc gcagctcagg aggaaggatc gctgagctgc
     6061 acccgctgtc ggaggagggg agagagtgcc gaagtatctt gtgcctgatt aagggcaggt
     6121 ggttctccgg ttctggccct gcccaaaacc aacgtcctgg ggccccgcta cgctgagcga
     6181 cgcctgcgac caacgatctc ccgtgctccg atgcccagac cagccagggc cagcaaggaa
     6241 atcagaccga agagccagag ctgggccgtc ggggtggcca tcgactgagg catggcattg
     6301 ggatcgctgc ccgtattggg catgcctggc acaccgctca ccgcggccac cacaaacttc
     6361 agctccggcg tccctttgta gagaccaacg gcgaaaacgc tatagaccat gccgctctgc
     6421 aaggttgctg agaccggcac ggtggcattg gcctgcgtgg ccgtcacatt gaaggtatag
     6481 gagccgggcg gcacactcaa atagtcgctg gcgttcttat acgtcagccc actaatgacc
     6541 gtcttgccgc cagtagcgat atcgaccggg ccggcgttgg gcgagagatg atagacccgt
     6601 accttggcca tgccgctgct gagctggttg ttatcgacaa acgcctgcag gcccagattc
     6661 gcagcgctat cgccgatggc ggccaccgtg taggccatat cggcatcaac cgagacggtc
     6721 tcgttgatga ccgctgcatc gatgcccttg cctgccggag ccacctggat acggtgcggc
     6781 cctgctgcca ccgagacata atcagtgacc gtaccaaagg cgaagttgct caagagcttg
     6841 ccaccgtcaa caaagacatc gacgttgccg gctgccggtg aggcatgaac gacgcgtacg
     6901 agagcgttgc cctgagcggc agcttgcccc acaggtagca gccagaggat caacgccagc
     6961 gcggctgaaa agatggagac cgctttcacg aatgccaaga gagttttgct acgcatcaag
     7021 tatcctcctt gttaaagata ggccggcggc gactggcacg tgccaaggcc aaggcggccc
     7081 ggcgcgcacc agtcacgaga gccaccgctc ctgtggccac ctcatcctgg tgagaaggca
     7141 ggatgacgag acaacaggac aaatgtgcga tcgtccctga tccaggaagg ccgtgaacag
     7201 agaggtaccc ggaattgcaa gatccaaccc aggagacgtc aggtctctat caaaatggta
     7261 ccagtatcta acatctctgc ctgattaccc attcgccatc ttctgcacgt cctgagaatg
     7321 gaacacctgg atcagagaag ccaccgaaga ggaagacaag catggggccg gggagccgcc
     7381 atgtgaggaa cgagaggtac gcattgtgtc acaggaacca tctggagtgg aaagagacag
     7441 ccgatggagg tctcctgctg gagagacggg gtcggaagga gtagaagcgc cgtcgcaagc
     7501 ggagcgagcg aatcgggcag atagcacaga aaatgctcga gactcctcct gggaaaaaga
     7561 gctggttgcg cgctgcctga ctggtgacga agaggccttt gcgcgtatcg ttgataccta
     7621 tgggggactg cttttgcgta cagcgtattt gttaatcaag gatgaggaag gggcaaagga
     7681 tctggtccag gagaccttct ttctcgcctg gaaaaacatg acaaccttgc gcgacccggc
     7741 gcttttgcgc tcctggctgc tcaagatcct ggtgaaccag gcgatcagcc tcaagcgcca
     7801 gcttgcccgg caggctaccc tcttgcgcga gcggctcgca ggcgaagaac aagagcaatt
     7861 gttaccgaag acgtcgctgc gcgaggggcg ggtagaggac tggctcgatg tggtggcggc
     7921 tttgcagcgt cttcccgtca aacagcgggt ggtgctggtc ctcttctact atcatcggct
     7981 gaccatgccg gagatcgccg ccatgctcgg ggtagccgag aacaccctgc gcaagcgcct
     8041 gcagctggcg ctcaagaaga tgcgccgcct cctgcagatt agaccccagg aacggccagc
     8101 ggcacaggaa gaggcagccg gcgccgatca gcccccgtct cagatcgctt cagggaggga
     8161 ggaacagcat gagtgatgcg cctcacgagc cgcagccaag cgaggagctg ccgacgggtc
     8221 agcccgcacg gtcggcagag cgccgtgggt ggcagggggc cgaggagcgg gagcaagtca
     8281 accatcgcgc ccctgtggac gatgttttgt tggaggaggt cattcggcgc gccctgcagg
     8341 agcaggcggc ccgtattcac ttctctcccg agctccgtgc gcgcatcctc agcgggctgc
     8401 cccctcgtac ttctgagcgc cgcagccagc tcagccgccg ctcgcgcctg gctctggccc
     8461 tggcagcgac cttgacgctg ctcctctgtc ttgtgctcct gctcctgctg ttcttgccgc
     8521 aggcgccttc ggggccgccg ctggccaatg gggtacgtta ccaggtggcg caggtgctgg
     8581 cagtgccacc agcgctagcc cagggcgggc gcctggtagc cgttgatccc acggggcgcc
     8641 atctggtgat ccaggatggg cgcgatccag gggtgatgta tactgccagc ctgagcgatc
     8701 ccgttggcag ccagcttctg gcgatgcgcg aggcccacga cgccgcctgg tcgcctgatg
     8761 gcacagccct ggtcaccgtg gtgacgccgc ccggggccgc gcagccgctg ctggcgctcg
     8821 tgccctatgg gcagtacatg tatccactgg gcgaggctgc tctggccgcc acctggaccc
     8881 ctggtgcggg cagtacgacc atcacttatg tcacaggggc gaacgggcaa actcagctct
     8941 ggcagacgac gcgcggcggg catccgacgc agcttctggc caccatgaac ctgcgcctga
     9001 ctgtccagca cctggcctgg tctcccgatg ggcgctatct ggccttgctc gtcagcaacg
     9061 agggcttgaa tggcccaggc cgcgccatct atctcatgga tcacgtgagt ggccaggtga
     9121 cagtcctggt acccttcggc gacttcacca tcaccagctt tggctggtcg cccgatggcc
     9181 agcggctcac ctatgcgcgg cgcgacgcgg caggtcacac cctgctgaca acgctggcga
     9241 tccccgacgg gcgcccgctg ctcagtctcc ctctgcaggg agagcttgat ggctggagct
     9301 ggtcgcccga tgggcgcgcc ctggtctaca gcgacgacgg gcgtctccac gtccacatct
     9361 tcgctggttc gcctatcgtg ctgccgcaac ccgaggccgg tgctcgccag ctcttcccgt
     9421 tctggttgcg cgatgggcgt ctgctgattg tccacgtagc ggccagcggc cagcgtacgc
     9481 tgcagctgtt agcgccggtg ccagctgctc cccgctctcc cagcgcctga tgaggctgaa
     9541 ccgggaaaat ctgctggctc tctgctccca ctcttctggg gagcgttctc gcccagtctg
     9601 ctggccggct ccggcgtaca ccccggctca ctgcgccaaa gagccgttac tagaagaggc
     9661 cggacggagc gtcatatgga aaggacctgg agcgtatgtc gctcgctatg cccatgatgc
     9721 ttgcctggcc tgacgccgtt gtggacttcc ccaggctatc gtgccttttc cctcgctgta
     9781 gccaacagag caggggcagg cgtgagttgt gctctctctg ctgccaatct ctaccctgcc
     9841 tgacaggtct ggaaagaagc ccctcggctg ctctgccatc tgtcggctga gccagggcgg
     9901 gcctgctgga gaggagcaga tagccgctat gcgcgtggtt aaaccgagct ttcagagaga
     9961 gggggcatct tcagcttcag ctggacctcc agaggagctt gtgagcgctt cctcactctg
    10021 ttctgtcccc gccgctgcag cgagtgaagc ccaagaggag gccctgcttg cacaccacgg
    10081 gagaaccttc catttcgcgg ctcgcttcct gcctggggag ttacgtccct cgtttgtgac
    10141 tctgtatgcc tttttccgca cgctcgacga tctggtcgac gagcgtaggc cagaggagga
    10201 gccgcgcgcc atcgccgaag agttgcgtgc ctggcgggcc tggttcctgg ccgaccgcca
    10261 gggaacggct ccgcgcgagc cgctcgggag ccgcctgacg caggtggtag agcgctatgg
    10321 agtaccaggc acgctcttcc tggattttct ggaggggctg cactgggatc tgtggccgcg
    10381 cgaattcgcc agcttctccc gtttgcgggc ctattgctat cgcgtggccg gcaccgttgg
    10441 gctggccctg gcccacgtgc tcggcgcgac ttccgggggg gcgctggcgg cggcggaggg
    10501 cctcgggatc gccatgcagc tgactaatat cctgcgcgat gtcggggggg acctgcgcaa
    10561 aggacgcctc tatctgcctc tggaggacct ggcccgtttc ggtctctctc gctctcattt
    10621 gctgcaactg ctcgatactg gtcaggggcc agatgcggcc ttccgagatc tcatgcgcta
    10681 cgaggtgaca cggacccatc tctgctatgc tcagagcctg cccggcgtct ggctcctgcc
    10741 acccgatcgc cgcctgccga ttctcctggc cgggcgtctc taccggcgca tcttgcacgc
    10801 cattgagcag catgactacg atgtgctgcg cgcgcgtgcc catacaaccc tgacggagaa
    10861 gctgcgcgag gccatgcttg ctctgaccct cgatcgcctc tggcgccgtg gtgagcagct
    10921 cggggctttc gggttggagg tgagccttga ggatgagccg taagctacta tggatgggct
    10981 ggctgggcgc gttctcagca gggcagctgg tcttggccct gcgcgtgatc ctccgctggt
    11041 tgcgcagcac tggcggccag cgcctgtcgg ctctctcttt gcctcatgct gatgccgcca
    11101 cgcaagccag cgtggcggtg ctggtgcctg tgctcaacga gcgcgaacgt ctgtccccct
    11161 gtctggaggg cctgctcact caaggaccgg aggtcgggct gatcctggtc attgacggcg
    11221 gctccgagga tgggacggac gagctggtct ctgcctatgc tcgccgcgat cgccgtctgc
    11281 gcctgctctc cgcggccccg attcctgacg gctggaatgg caaggtctgg ggtctggaag
    11341 ccggctggcg cgcacttccg tctaccttcc cctgggtgct gaccattgat gccgacgtgc
    11401 gaccagggcc gggcctggtg agcgcgctgc tggcccgcgc cagccgcgac aggctggcgg
    11461 ccctcagcct ggccacagag caggagctgc cgccggcgcc gctcttgggc ttgctccatc
    11521 cctcgctact ggccaccctc gtctaccgct acggcctgcc cggcgtggtt tatgagggac
    11581 cggtcgatag gctgcgcgta caggccaatg gccaatgctt tctggtgcag cgcgaggccc
    11641 tggctgcctg cggtggcttt gcccctttgc gtcactcgct ctgcgaggac attaccttag
    11701 cgcgcctgct ggtgcaggac ggtcgacgcc tggccttcgt cgaagggggg agcctggcct
    11761 ctgtcgagat gtatcgcacg gcgcgcgaag cctggcagaa ctggacgcgc tccctgccgc
    11821 tgcatgatca tctcagtccc gcctggcgta cctgcctcgg ctggctggag gtcttactgg
    11881 ttcaggctct gcctctcccc ctgctcagcc tgctcgcggg cgcgctgatc gccgggcgga
    11941 ggcgctggcg gcaggcttca ctctggctgc tcgtcgccat gctgggcctg aatgccgggc
    12001 tgctgctgct ccgtctcggg accctggtag gtatgcgtcg cgcttatcgt cgtcctccct
    12061 ggacctactg gctctctccg ctctgcgacc tggcggtgac gctgcagctg ggccggcagg
    12121 ccctgcggcg tcgtcatcgc tggcgcggac gcctcatcat ccgtggaaac gctcctggag
    12181 gtattgcatg aaagccgtaa aggtgctctt tatttgccat ctggcggcgc tcatcttcgg
    12241 tcttgccggg ctgttgatcg ccctgcccca tcccgaactg tggagtttta gcccgctgct
    12301 ggtctcggtc ttcagcttcg gcatcaacta tgccggttcg ctgcacatcc tctttggggc
    12361 ggccacggtg ctcctttttg ggctacgggt ggtgggggta cgccgcaccc tgatcttctt
    12421 cgccgcctcg acgttgatct cgctcagcat agagctgctt ggaacctcga ccggctttcc
    12481 cttcggtccc tactcctaca acagtttcct gggcttcaag atccttgatc acgttcccta
    12541 ttcgatcccg ctctcctggt tctacatggg cttctcctcc tttctgctgg cccatctgct
    12601 tctgacccgt cgtggccaag gcgtcggcca gcgggggcgt ggcctgtgga ccgtgctgct
    12661 gggtgcctac ctgctgaccg tctgggacct gacgcttgat ccagcgatgg ccagcgagcg
    12721 gctgcctctg cacttctggc agtggggagt aagcggagcc tacttcggca tgcctgtcca
    12781 aaatctagtt ggctggtcgg tcactggctt gctctatatg ggcgtcagtc ggctgctctg
    12841 gcgcagcgat ctcgaagagc gccgcctgca gggcgtggcc tggctgccct ttggcgtcta
    12901 tgcggccaat accctctttg ccattgtcct cgatctgagc gttggtctct ggctgccacc
    12961 actgctgggc ctcttgctgg gtatactgcc ggcggccctg gtgctacgcc gtgatggcag
    13021 cgaggggggt gagcgcggga gtggccgccc tgtgccgacg ctctcggagc gggctgagct
    13081 ggctccggat ctggcccagg cccaacaggg gagccgtggg cttgaagcgc agagccgggc
    13141 agaggggcag gccctgttgc agaggattgc ccgtctggtc atgcgcgtcg gggcgggcat
    13201 cttgctctgg cgccgccggc tgcgcatcat cgttgaggga cgcgagcatc tgccagccta
    13261 tggcccggtc attgtcgccg ctcgccacta tcaccatctc tacgatggtt gcctgttctt
    13321 gcgagtgatc ccacgtccgg tgcacatttt ggttgccctc gactgggcgc gcagccgctg
    13381 gcagcgtcgg ctcatggagc tgctttgtgc tctggctggc tggccggtta tcttgcgccc
    13441 tgagcgcctg cgccccgaag agacaggggc ttccgtcagt gcctaccgtc tgggcgaggt
    13501 cgccccctat ctacgtcgag ccttacgtca ggcccggacc ctgctctgtc gcggcgacct
    13561 gctggtcatc ttccccgagg gctatcccgt ggttgatcct cagccctcac cgcgctcccc
    13621 ggagcaagcc ctgctcccat tccggcccgg cctggcccgc ctggtggagc tggccgagcg
    13681 tgcgagtgga accagcattc cggtggtgcc agcgggcatc atctggagcg agacgcgccc
    13741 gccgttgctg accctgcgtc tgggggcgcc cctcttccgt cgcctctacg ccgacactgc
    13801 ccaattcatg agtgcgctcg agagttgcgt gcgggcgctc tcagggcttg atcacgacca
    13861 gggcctgagc ctgagcctct ttcctggaaa ggagatgctg cactcatgag cagtcgctct
    13921 agcgtcacat ctgctgccaa caggctgccg gcaggaggaa gcggcgtgcg cccgcgggtg
    13981 attgtcatag gggccggttt cggcgggctg gcggcggcca ttcgtctgca ggccgccggg
    14041 gcccaggtca tcttgatcga ggcgcgttcc cagcctgggg gccgggccta ccagctcaaa
    14101 gccgagggct tcacgttcga catggggcca agtctgctga ccgcgccctg gctcctgcag
    14161 gatctctggc aggccgccgg gcgccatctg gacgaagacg tgaccctggt gccgttgcgg
    14221 cccttctatc gcattggctt tgccgacggc aatcacttcg actactgggg tgaccccgcc
    14281 gctgacgagg ccgagatcgc ccgctttgat gcgcgcgacg ttgccggcta ccgcgccttc
    14341 ctggcggcga cggaacgcat ctaccagcga gcctttgccg agctggccgg agagccgttc
    14401 ttgcgcctga gcgatttcct gcgcgtggct ccagagctgg tgcgcctggg cgcccaccgt
    14461 agcgtctacc gctttgtctc gcgctacttc cgccatccgc aactgcggat ggtcttctcg
    14521 ttccatcccc tcttcatcgg cgggaaccct ttccgggcca gcgcgatcta cagcattgtc
    14581 ccctatctgg agcgtctggg tggcgtccat ttcatccctg ggggaatgta tgcgctcgtc
    14641 gaggctatga cccgcctctt taccgcgctg ggcggcgagc tgcgctgcgg ccagcccgtt
    14701 gagcgcatcc tggtgcgctc cgggcaggtc tggggcgtct tgctggccga cggcgctctc
    14761 ctgcaggccg aggcggtggt ggccaatagc gacgttgcca ccacctatct gcgcctgctc
    14821 cccgccgaag tgcgcccccg tgggctggtg cgtcgcctgg agcgggccca ctactcgatg
    14881 agctgcttct tgctctacct gggactgaag cggcaatatc cgcagttgcg ccatcactcc
    14941 atctttatgc cccacgacta tcgggggttg atccggcagc tctttgacgg ccagggcctg
    15001 ccggctgatc tggcgctcta tctgcacacg ccgacccgca ccgatgccac gctggcccca
    15061 cctggtggtg agagcctcta cgtgctggcg ccggtgccgc atttggggca cggcgtcgac
    15121 tggcagcgcg agacgctgcc ttttcgcgag cgcattctgc gctatctcga agagcaggcg
    15181 ggcctgcacg gactgcgcgc cagcatcgtc tacgagcagc gctttacgcc cctcgacttc
    15241 gccgacgagc tgcgcagcca tctgggtgcg gccttctcgc tggagccgac gctgttccaa
    15301 tcggcctact tccgtccaca caaccgcgct gcccaggttg ggggcctcta ctttgtgggt
    15361 gccggtaccc atcccggggc gggcatcccg ggcgtcctgc tctccgccgc cattacggct
    15421 cgtcttgtgc gggaggacct ggcatgccgt gcctgaagga gcgctgtcag cctgatggcc
    15481 cgcacgtggg gggaggaaag ggagcggcat gagacttggc tatgcctgtg tgaatctctc
    15541 gctggggggg aagatgcgca gtctgcgcct ggccaccctg cgcgagcgcg gccttgccta
    15601 tctgcaggcc ctcgtcgatg agaacctggc gctactcgtg gccatcctgc gctggaacct
    15661 ggcccagggt atcagcgtct tccgcatctc ctcagatctg gtgccgcttg gctctcatcc
    15721 cgaggtggcg ctagagcaga tccgctttga tccggctcgg gttgccgaag tgaggcagct
    15781 ggctcgcgcg ggtaggatgc gcctgtcgat gcaccctggt caatatacgc tgatctctgc
    15841 cgatggtcct gtctggaaga gcagctatcg cgacctctgc tatcatgcag aggtcatgga
    15901 acgactcggc ctcgaaggtg atatcatcct gcatggtggt ggtgtctacg gcgaccgtgc
    15961 tgccacgctg cggcgtatcc tgactcacat cgatgagcta ccggagagtg tgcgccggcg
    16021 gctgcgcctg gagaatgatg agcgctgctg gtcggtgagc cagctcctgc cgatttgcga
    16081 ggcgagtggc ctgccgcttg tggttgacaa cctgcatcat accctcaacg gtggcgcgga
    16141 gaccccgctg gagcgcctgc cctgggaacg tatcctgaca acctggggcc ggctccggcc
    16201 caagctgcac tacgctgagc aggaccctgg taagcgtccc ggcgctcaca gcgagtacat
    16261 caatgccgac cgcttccggg cctttctcac tgctgttccc tggtctgact atgacgtcat
    16321 gcttgagtgc aaagccaagg acctggccct gttgcgcctg cgtcaggagc tgggcctgat
    16381 cgctgccgga cccctgcccg gagccggtga gggcagcgat catcaaggct gaggctgagg
    16441 tgactcgtat ccgggcgcct tcacgtgctt aattcaggtg aggtaaagca gcgatcgcgc
    16501 tgcctgttga tgcagaaagg agagagaggc gtcaccatga tcatcgttgt cggtgccggt
    16561 ctggccggcc tgacctgcgc ccgccacctg agtcgcgccg ggctgagcgt cctggtactg
    16621 gaggccggcg accggcccgg aggccgcgtc agcaccgatc gccatcccga gggcttccta
    16681 ctcgaccggg gcttccaggt cttgtttact gcctatcccg ccgtgcagcg cgagcttgat
    16741 ctcgctgcac tcagaccgag acgtttcctg cctggggcct tgctggtcaa agggggccgg
    16801 cgctatccgc tagctgatcc gcgacgccag ccaggctggc tgactgcctc tgccagcaac
    16861 cccctcattc cgctgaccga caagtggcgc gtcctgcgcc tgacgcgcac gatcctgcag
    16921 acggtctctg tggaaagccc ggcggcctgg cccgtggcca cgcttgacga gaccagcgag
    16981 ctgtacctgc gccattgggg ctttagccgc aagggcttca tcgctcactt cgctcgtccc
    17041 ttcttcggcg gcatcttcct cgatcgagag ctgcagacca gcgcgcgcat gctccgcttt
    17101 gtctggcgca tgctggcgag cggcgatatc gtcttaccgg agcagggcat gggagcgatc
    17161 actgcccagc tagcggcctc tctgccagag aacagcctgc gtctgggagc gcgcgtcgag
    17221 gccttgctgc gtgaggacgg acgagtctcg ggcgtgcgtc tggagagcgg tgaggagctg
    17281 cgggccgaag ccgtcgtgat tgccaccgat agcccgacgg cggcccgtct taccggcctg
    17341 tccttgccaa ccgcaggccg cggctgcacc tgcctctact tcgctggccc tcagccgctg
    17401 tacgatgagc cagccctgct gctcaactgt cagcctgacg gactggtgaa ccatgctgtg
    17461 cagctcacca atattgttcc gcagtacgct ccatcggggc agcacctgct ctcggtcacc
    17521 atcctggatg cagcggccca ggctgaagaa gacgatgagc ggctggctca gcgcgctcta
    17581 caggagctgg cctcctggtt cccagagcat gacctgcagc gctggcgtct tctggccgtc
    17641 tatcgtcttc cctttgcgca gttcgcccag ccgccgggca tcttcgccca tctgccgggg
    17701 gcgcgcagtg gggagccggg cctctatcta accggcgaat acctgcattc gagcagcatc
    17761 cacggcgccc tcagcagtgg agcgcataca gcgcggctgg tgctcgccga ccagcgggag
    17821 tggctgcgcc ctgccgggtg agaagaagga gcgagaaacg atgcaagagc ttgttgaacg
    17881 tcgtccaccg acctggcgtc ctgggcgggc ggcgctggct ggcctcctgg ccacgggcgt
    17941 ctatagcctc gtcatggctc tcgaccagcg cctcagcggc aaccacttca gcgacgtgcg
    18001 cttcatcgag ggcctgctcg ggggaggaac aagacagcct gacggtcgcc gtctcctggc
    18061 ctggggcctc catctgctca atggggtcct gctgggcgaa atctatgccg ccctggtcag
    18121 accgcgtctg cccggcccga tctggctcaa gggactcctc ttcggcgaag gctttctggc
    18181 ctcagtctgg tggctcacgc ccctggccga ccgtgtgcat ccgctcattc gccgcggcca
    18241 gctcccgcgc ctggcgacct ggtcctcctt tgggcagaac ctcctgcgcc atctggcctt
    18301 tggcctgacg ctggccctct tctacggcga cgagcgcgag ctgccaccgc gcccctgacc
    18361 ggacctcgcg ccctgcgctc ctggctggca tcggtggatg tagatccttt tcttagagag
    18421 cttgctagag tggaactgtg aggacggaag gcggtggagt gtgaggggaa cccggaaagc
    18481 aagcaagctc taataggaag agcacagaaa ggatcaatcc atcgccatga agacctatat
    18541 caatcgcagc tcttcgcgca agcagcaggg gcggcggcgc tttctccaga gggccactgc
    18601 gggcctgggg ctggctactg gtggtctcac cctgcttgga agcggcgcca ggccgctggt
    18661 ggtgcgcgcc cagggagcgc tgactgagcg gctcgttacc ctcgatgatg ccgtcacgca
    18721 gattctctcg atcgcgcgta cggcggagca gctagccgtc accttctaca gcaacggcat
    18781 cgctaacgcc gaggcgctgg gcatcagcgg cgatgacctg gcctatctca aggcagctct
    18841 ggtcgaagag cagattcacc agcagttttt cacagccaac ggtggccaat cgctggctga
    18901 cacctttagt ttccccaaag ggtcccagac cttcagcgac ctcaagacct ttatcgagac
    18961 ccagcagcag ctagagggag tctttgattc cgctttcctg gcggccatca aagagtttgc
    19021 cgcgatgggg cggcctgatc tcgctcaggt tgccgggcag attgcctgta ttgaggccga
    19081 gcatcgtgcc ctggggcgag tcatcggtgg cctgcgccct gccgataact gggccttcac
    19141 cccggtactg atcgccagcg tcgccgatgc tccccaggtc gtgcaagacg ccggctacct
    19201 cagccccacc gaagggaaca gctaccgcta ccatgaggtc agcaccgaag acgctggcgt
    19261 cgaacagcgc gtaccctttg tggccagcag cggcgtcggt cgcggttaag atccaatcaa
    19321 gcagaatagg gggcgcggaa gggcagggaa agccatcccg gtgcactgct gagaagccaa
    19381 agaaggtttg aaaaaccttt tccagtccag ggggaaccgt ctatctctct ctaccttaaa
    19441 taaagaagag aggcagtcac agtcaaatag ggaaggccgc cgtcttgctc ttgtacttgc
    19501 ttgctccctc cctcccgttc gtggctggct cccagcctga tgacgaactg ctgaacgggc
    19561 aggcaatgga tgagagacgg cggcctcttt gctgaagcag tgtgacctgc tgactgttct
    19621 ggctgactgg aggcgcgcag ttgagggctg actagagacc ctgcgaggcg gcactgaggc
    19681 gggctagctg ctctggggtg agctgcagcc ccagggcggc aaagccatcc tccagatggg
    19741 ctggctggct ggcaccgatg atgggagcgg tcaccgccgg ctgggccagg agccaggcca
    19801 gggctactgc cgcgggcgta gcctgggtct cctcggcgac ggcctgcacc gcctccagag
    19861 tgcgccaggc ctgctcttga tcgtagcgtc ccagcacagc ggcggcgcgc gcactctggc
    19921 ggccctcacc gcggcggtag ctgccgccga ggaagccact ggccagagga ctgtagggga
    19981 tcacccccag gccatactgc aggcagatgg tctgcagctc ctgctcaaac tcagcccggt
    20041 gcaccagatt atagtgtggc tccagcacct catagcgggc tgtgcactca tagcgcgcgc
    20101 accagagcgc ctcgaccagc cgccaggcgg ggtaattcga agcgccaatg tagcgcacct
    20161 tgccgctgcg ctggaggtcg tcgaaagcgc gcagcgtctc ctcaatcggc gtctccgcat
    20221 cgaaagcatg agccagatag agatcgagat agtccgtctg caggcggcgc agcgaagcct
    20281 caacggcctc tatgatatgc ttacgcgaga ggccgcgctc gtttggtccc tcgcccatcg
    20341 gatgatagac cttggtggca atcaccacct gactgcggtt gccgcgtgca cgcagccagc
    20401 gcccaatgat ctcctcagat tcgccgccgc gcttgcctgg aatccagcgc gcgtagaagt
    20461 cggcggtgtc gaagaaattg cctccgcgct caacaaaagc atccatgata gcgaaggctg
    20521 tcggctcatc gaccgtccag ccccactgca tggtgcccag acagaggcgc gagaccttca
    20581 agccggttcg tccaagtgtg cggtactcca tacttcttat tgtcgcgcgt cgcatccctc
    20641 aatgcaaggg caggccctgg cgcttagcga ccttgagtat ccgggccaga ctggcgctcg
    20701 tactggtcag gtggaacgga tgaggatggc tcagcagact gatctgaaga atgagcggcg
    20761 tctgatcgat ctgaagcgac ctgatcgccg tcagccggct ggggggcagt atccttcctc
    20821 gcttcgcagc tgagacggcg cagcaggaag cgggtctgat cggagagagc gcgcgtgtga
    20881 aaaaccagct cctcataata gtgaagcagc tgctcccagc tctgcaggaa ggtctgtagt
    20941 tgacgctggc gctgtcgggc tgg
//
