LOCUS       NZ_MCIF01000002        30587 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Thermogemmatispora tikiterensis strain T81 A4R35_scaffold00002,
            whole genome shotgun sequence.
ACCESSION   NZ_MCIF01000002
VERSION     NZ_MCIF01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Thermogemmatispora tikiterensis
  ORGANISM  Thermogemmatispora tikiterensis
            Bacteria; Bacillati; Chloroflexota; Ktedonobacteria;
            Thermogemmatisporales; Thermogemmatisporaceae; Thermogemmatispora.
REFERENCE   1  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Analysis of Carbohydrate Active Enzymes in Thermogemmatispora T81
            Reveals Carbohydrate Degradation Ability
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-AUG-2016) Faculty of Agricultural and Food Sciences,
            University of Manitoba, 66 Chancellor's Circle, Winnipeg, Manitoba
            R3T 5V6, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2011
            Assembly Method                   :: Newbler v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 25.9x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003268475.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 03:19:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,660
            CDSs (total)                      :: 4,607
            Genes (coding)                    :: 4,541
            CDSs (with protein)               :: 4,541
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 8 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 6 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:11:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2088355
            Orig. end                         :: 2118942
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MCIF01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..30587
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /product="lanthipeptide-class-ii"
                     /region_number="7"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..30587
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="neighbouring"
                     /product="redox-cofactor"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..22406
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22406
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12406](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12406
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            1036..1944
                     /locus_tag="A4R35_RS08345"
                     /old_locus_tag="A4R35_08295"
     CDS             1036..1944
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021505.5"
                     /locus_tag="A4R35_RS08345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08295"
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_189361546.1"
                     /transl_table=11
                     /translation="MSDTTHEPVPSTTNIWQSFADRFGDSLQALARTLTGGTQKPPRLL
                     KSLLSGTFGGHPLHPAITDIPIGAWTLTAILDIIWLAAPAGNSWAARGALVGAIVGLIA
                     ALGALFTGLADWSDTYGAERTVGFYHGLLNTAAFLLYLVSLILRLISPLNESIAAAVLG
                     FIGFVAILVAGYLGGDMVFVKGTNVNHTAWEAAGEDFEPVLPASNVEEGHLYRVTVAGV
                     PVVLLRRGEQYYAISATCPHAGGPLDEGTLDGDVVECPWHGSRFCVRDGRVLTGPATVP
                     APRYAVRVRNGQVELRRLGGH"
     gene            complement(2097..2345)
                     /locus_tag="A4R35_RS08350"
                     /old_locus_tag="A4R35_08300"
     CDS             complement(2097..2345)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007922981.1"
                     /locus_tag="A4R35_RS08350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08300"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_112428347.1"
                     /transl_table=11
                     /translation="MARRESAVVDRERDSREEYTTELLTVSEVAKRLRVDDTTVRRWIK
                     TGALQAITLPHKGKREVYRVKKNTLDELLNTPATAAS"
     misc_feature    complement(2465..2479)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.68"
                     /tool="antismash"
     misc_feature    2611..2624
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.05"
                     /tool="antismash"
     misc_feature    2611..2627
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 22.2"
                     /tool="antismash"
     misc_feature    3032..3047
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.58"
                     /tool="antismash"
     misc_feature    complement(3072..3081)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            complement(3094..4002)
                     /locus_tag="A4R35_RS08355"
                     /old_locus_tag="A4R35_08305"
     CDS             complement(3094..4002)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015377.5"
                     /locus_tag="A4R35_RS08355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08305"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_112428350.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.2e-05, bitscore:
                     23.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVPFMVLASALLLLMLGLSLWRRGSWLERWLRREGLASALLVSSS
                     GEQASLTARTARLLQRAQDGQEGKPWFAQTIPAPWYRRWRVILSLLLLVMVLLALSMTS
                     ALADGGQLTLNAALTFFRNNHGQTLDLQTLPHGFNASRSLVRISQLDPAQYASQEEYDT
                     WAYSACSAAAMTEVFNAYGRHYRISDVLHVEAALGQITPELGLVSPDGIAITAAHFVFR
                     TEWGEHWSLEQLLAVANNGAPVIVSFPPDRYAGGHLLVVLGGDATSVYLADSSAWNRRV
                     LSREQFLQWWGGYAAVVTPLE"
     gene            complement(4170..4649)
                     /locus_tag="A4R35_RS08360"
                     /old_locus_tag="A4R35_08310"
     CDS             complement(4170..4649)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS08360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_08310"
                     /product="hypothetical protein"
                     /protein_id="WP_146747146.1"
                     /transl_table=11
                     /translation="MYRRNHFGRHRGWFFWWFIPLFFLGPAHWWWGWGSAMFGIMLSIF
                     FIALLAWALSVLFAEQGPGAGRSWPMSGGMWQWQQQPPQAPPGPMDTYQTSYPGSQPGE
                     PERRYHQGYRAQTGPRSSEAAEPQPQQAQPMARRPQPQYEEPQVEYPREEPPLVQ"
     misc_feature    complement(4705..4721)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.05"
                     /tool="antismash"
     misc_feature    complement(4949..4963)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.82"
                     /tool="antismash"
     misc_feature    4950..4963
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.31"
                     /tool="antismash"
     gene            5042..6145
                     /locus_tag="A4R35_RS08365"
                     /old_locus_tag="A4R35_08315"
     CDS             5042..6145
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024755.5"
                     /locus_tag="A4R35_RS08365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08315"
                     /product="toprim domain-containing protein"
                     /protein_id="WP_189361547.1"
                     /transl_table=11
                     /translation="MASMITIFTRRGKRIEILSQSELRHPRLTGNRVRAFCPIHGSDHQ
                     RSLSIDPASGWGYCFNASCQAKVLIAEWNPGAAHHLLAANASGSRGQASAQEGSTGSQT
                     SSPFHWLSQPEERPSSVSVLNRWQEEERRILQALEPTMQAALKSSSLGRAYLRERAIPL
                     EIALTGGVGLLTPTIITRLTHSKQRRLLQRWSGRLIFPLQAETTRGYIGRTLVGWQPGM
                     DENAHKQLLERPGRPQRWIKTNPAGCFSLPREQLAPQLIVVEGTFDRLALLAAGLRANE
                     VVALAGTALPLSWLPAQVRSVLLALDGDEGGREATTRLSAQLREQGRAVSCCLMPLDGQ
                     GKDWNERWRLAGRAGLQPLLDSYRRLY"
     gene            6276..8279
                     /locus_tag="A4R35_RS08370"
                     /old_locus_tag="A4R35_08320"
     CDS             6276..8279
                     /EC_number="6.2.1.16"
                     /GO_function="GO:0030729 - acetoacetate-CoA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (100-532). E-value: 1.2e-55.
                     Score: 180.7. Matches aSDomain:
                     nrpspksdomains_A4R35_RS08370_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007907282.1"
                     /locus_tag="A4R35_RS08370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08320"
                     /product="acetoacetate--CoA ligase"
                     /protein_id="WP_112428356.1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-59, bitscore:
                     199.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSFNAEQPLWEPSEELKEQANITHYMRWLAEQRGKQFASRHEL
                     WEWSVADLEGFWSSLWDYFQIQASQPYTQVLASRSMPGARWFPGAELNYAQHVFRQASA
                     EHPAIIFRSEREPWRTLSWKELEQAVGAVAQALRQLGIKRGDRVVAYLPNIPETVIAFL
                     ACASLGAIWSSCSPDFGTSSVVDRFQQIEPRVLFAVDGYQYNGRSFDRRGVLAELQTAL
                     PTLEHTIIIPYLHATPEEARAGLSKTIPWSSLLAQPAPLTFEQVPFEHPLWVLYSSGTT
                     GLPKAIVQGQGGILLEHLKVLSLESNLKPGDRFFWFTSTGWMMWNFLVSGLLVGATILL
                     YDGAPGYPDMNTLWRFAQDSGMNLFGTSAAYISGCMKAGIEPGKEFDLSQLRCIGSTGS
                     PLPPEGFRWIYEHVKRDVWLASVSGGTDVCSAFVGGCVLLPVYAGEIQCRALGARVEAF
                     DEEGRSLIDEVGELVVTAPMPSMPLFFWNDPDNRRYRESYFEMYPGVWRHGDWIKITPR
                     GGAIIYGRSDSTINRQGIRMGSSEIYRVVESFPEVLDSLVVGVERPGGGYYLPLFVVLR
                     EGVRLDEDLQRRLKEALRREISPHHVPDEIIAIPEVPRTLSGKKMEVPVKKLLLGMPLE
                     KAASPDAMSNPQAIQFFVDFARQLQARSGSTP"
     aSDomain        6576..7871
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A4R35_RS08370_AMP-binding.1"
                     /evalue="1.20E-55"
                     /label="A4R35_RS08370_AMP-binding.1"
                     /locus_tag="A4R35_RS08370"
                     /protein_end="532"
                     /protein_start="100"
                     /score="180.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QASAEHPAIIFRSEREPWRTLSWKELEQAVGAVAQALRQLGIKRG
                     DRVVAYLPNIPETVIAFLACASLGAIWSSCSPDFGTSSVVDRFQQIEPRVLFAVDGYQY
                     NGRSFDRRGVLAELQTALPTLEHTIIIPYLHATPEEARAGLSKTIPWSSLLAQPAPLTF
                     EQVPFEHPLWVLYSSGTTGLPKAIVQGQGGILLEHLKVLSLESNLKPGDRFFWFTSTGW
                     MMWNFLVSGLLVGATILLYDGAPGYPDMNTLWRFAQDSGMNLFGTSAAYISGCMKAGIE
                     PGKEFDLSQLRCIGSTGSPLPPEGFRWIYEHVKRDVWLASVSGGTDVCSAFVGGCVLLP
                     VYAGEIQCRALGARVEAFDEEGRSLIDEVGELVVTAPMPSMPLFFWNDPDNRRYRESYF
                     EMYPGVWRHGDWIKITPRGGAIIYGRSDSTINR"
     CDS_motif       7095..7139
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A4R35_RS08370_0001"
                     /evalue="6.80E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="A4R35_RS08370"
                     /protein_end="288"
                     /protein_start="273"
                     /score="12.7"
                     /tool="antismash"
                     /translation="VLYSSGTTGLPKAIV"
     cand_cluster    7243..30587
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    7243..30587
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[17242:20587](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      17243..20587
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="2"
     CDS             complement(8709..8897)
                     /gene="allorf_2097064_2097252"
                     /locus_tag="allorf_2097064_2097252"
                     /protein_id="allorf_2097064_2097252"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLTFRSPGQQSRTRQGIDRSQTGSREEAGPAQSPPPPSTAHPSSI
                     SALCLLSPCLARYYCLF"
     CDS_motif       complement(8826..8897)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLTFRSPGQQSRTRQGIDRSQTGS"
                     /locus_tag="allorf_2097064_2097252_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8709..8825)
                     /prepeptide="core"
                     /locus_tag="allorf_2097064_2097252_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.20"
                     /molecular_weight="3905.5"
                     /monoisotopic_mass="3903.0"
                     /core_sequence="REEAGPAQSPPPPSTAHPSSISALCLLSPCLARYYCLF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLTFRSPGQQSRTRQGIDRSQTGS"
                     /leader_location="[8825:8897](-)"
                     /alternative_weights="3923.5"
                     /alternative_weights="3941.5"
                     /alternative_weights="3959.5"
                     /alternative_weights="3977.5"
     CDS             complement(8761..8907)
                     /gene="allorf_2097116_2097262"
                     /locus_tag="allorf_2097116_2097262"
                     /protein_id="allorf_2097116_2097262"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MEVFAHFPQPRPTKQNQTRHRPQPDGEQGGGRTCSVSAPSLYGSP
                     FLH"
     CDS_motif       complement(8818..8907)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEVFAHFPQPRPTKQNQTRHRPQPDGEQGG"
                     /locus_tag="allorf_2097116_2097262_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8761..8817)
                     /prepeptide="core"
                     /locus_tag="allorf_2097116_2097262_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="1789.0"
                     /monoisotopic_mass="1787.9"
                     /core_sequence="GRTCSVSAPSLYGSPFLH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEVFAHFPQPRPTKQNQTRHRPQPDGEQGG"
                     /leader_location="[8817:8907](-)"
                     /alternative_weights="1807.0"
                     /alternative_weights="1825.0"
                     /alternative_weights="1843.1"
                     /alternative_weights="1861.1"
     gene            8962..9894
                     /gene="pqqB"
                     /locus_tag="A4R35_RS08375"
                     /old_locus_tag="A4R35_08325"
     CDS             8962..9894
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012948559.1"
                     /locus_tag="A4R35_RS08375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08325"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_112428358.1"
                     /transl_table=11
                     /translation="MLVRLLGTAAGGGFPQWNCNCSNCQGLRAGELKAKARTQSCVAVS
                     ADGERWFLLNASPDLRIQLEGFPPLWPPASCRRGTPIEAILLTDADLDHTLGLLLLRER
                     SALTIYAPVAVQQALRQGLVLPQLLAHYCCVEWREPAEELAPLPTAAGHESGLLYQAIP
                     LTGKPPRYLDLAEASTLATGSPFRVGYYLTDVRTGGRLLFLPGLARQEEQLQPYLRACD
                     AILLDGTFWSEHELQEQGLVQATASSMGHLPISGPAGSLAWLAQLPIPYRIYTHINNTN
                     PVLVEDSPQYATVYAAGVIIGWDGLELQL"
     gene            10001..10777
                     /gene="pqqC"
                     /locus_tag="A4R35_RS08380"
                     /old_locus_tag="A4R35_08330"
     CDS             10001..10777
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672940.1"
                     /locus_tag="A4R35_RS08380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08330"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_112428360.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.8e-99, bitscore:
                     330.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTVILEPWDHETFVAQLRAVGMTRYHHLHPFHQAMNRGALSPEQ
                     IRAWIVNRFYYQQHIPMKDAAILANCPLPEVRRLWLHRISDHDGEHEDEGGIAAWLKLA
                     EASGLSREEVLSGRHVLPGVRFAVEAYVTFARQQPWPLAVASSLTELFSPDLMSERLAA
                     FERYYTWISPEGLTYFRARLQQAPRDAAQALELTVRYCTTRQLQEGAVQALAFKCDVLW
                     SMLDALQFAYGPLPGEPAQTAASTSAPTPAPQEGRL"
     gene            10774..11079
                     /gene="pqqD"
                     /locus_tag="A4R35_RS08385"
                     /old_locus_tag="A4R35_08335"
     CDS             10774..11079
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Thurincin_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03859.1"
                     /locus_tag="A4R35_RS08385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08335"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_112428362.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.9e-21, bitscore:
                     73.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-17, bitscore: 62.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.3e-09,
                     bitscore: 35.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 1.6e-07,
                     bitscore: 29.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPGEGSFPPPKVLRPRLLPRARLEIDRLSQRPILLYPEGVMML
                     NETAAAILQLCNGEYTLADILRELANRYEASPEQLQDDVYEYLCSLRDQNLVAWLE"
     aSDomain        10819..11064
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R35_RS08385_PqqD_RRE.1"
                     /evalue="1.10E-23"
                     /identifier="RREFam006.1"
                     /label="A4R35_RS08385"
                     /locus_tag="A4R35_RS08385"
                     /protein_end="97"
                     /protein_start="15"
                     /score="73.7"
                     /tool="antismash"
                     /translation="RPRLLPRARLEIDRLSQRPILLYPEGVMMLNETAAAILQLCNGEY
                     TLADILRELANRYEASPEQLQDDVYEYLCSLRDQNLV"
     aSDomain        10903..11052
                     /aSDomain="Thurincin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a thurincin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R35_RS08385_Thurincin_rSAM_RRE.1"
                     /evalue="9.50E-10"
                     /identifier="RREFam019.1"
                     /label="A4R35_RS08385"
                     /locus_tag="A4R35_RS08385"
                     /protein_end="93"
                     /protein_start="43"
                     /score="29.4"
                     /tool="antismash"
                     /translation="MLNETAAAILQLCNGEYTLADILRELANRYEASPEQLQDDVYEYL
                     CSLRD"
     aSDomain        10903..11067
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R35_RS08385_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.40E-11"
                     /identifier="RREFam002.1"
                     /label="A4R35_RS08385"
                     /locus_tag="A4R35_RS08385"
                     /protein_end="98"
                     /protein_start="43"
                     /score="35.2"
                     /tool="antismash"
                     /translation="MLNETAAAILQLCNGEYTLADILRELANRYEASPEQLQDDVYEYL
                     CSLRDQNLVA"
     gene            11168..12406
                     /gene="pqqE"
                     /locus_tag="A4R35_RS08390"
                     /old_locus_tag="A4R35_08340"
     CDS             11168..12406
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006020165.1"
                     /locus_tag="A4R35_RS08390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08340"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_223258252.1"
                     /sec_met_domain="PF04055 (E-value: 5.1e-19, bitscore: 67.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8.5e-06, bitscore: 24.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.5e-12, bitscore: 45.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.2e-11, bitscore:
                     41.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLNEQQMKPSPSPGTHQPEDALSQAALGNTLRPFGLLAELTYRC
                     PLRCPYCSNPTQILSDQRQPELTTSEWQRVIGEAATLGVLHLLFSGGEPLLRRDLPVLV
                     DSARSIGLYTNLITSALGLTRRRLQELREAGLDSVQISFQADEAALADGIAGCPGAHEH
                     KLEAARLVNACGLPLTINVVLHRGNIERLPALITLAERLGAQRLELASTQYLGWAFCNK
                     VALLPTKAQVQQAETIVRAAQERLRGRMEVIYVWPDYYAERPKPCLYGWGRRYLTITPE
                     GEVLPCQTARVIPNLHFDNVRQHSLAWIWQRSAAFERFRGSHWMPEPCRSCPLREQDFG
                     GCRCQAFLLTGDAANTDPACSLSPHRARLLAILSEVEQQSGSSPSFHRPFAPDGRPLIP
                     ILFRTNPKSCPGE"
     CDS             12439..12525
                     /gene="allorf_2100794_2100880"
                     /locus_tag="allorf_2100794_2100880"
                     /protein_id="allorf_2100794_2100880"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MAGDNQHESIAGRPLCDRSREEVIASDG"
     CDS_motif       12439..12474
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAGDNQHESIAG"
                     /locus_tag="allorf_2100794_2100880_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12475..12525
                     /prepeptide="core"
                     /locus_tag="allorf_2100794_2100880_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.00"
                     /molecular_weight="1766.9"
                     /monoisotopic_mass="1765.9"
                     /core_sequence="RPLCDRSREEVIASDG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAGDNQHESIAG"
                     /leader_location="[12438:12474](+)"
                     /alternative_weights="1784.9"
     gene            12518..12760
                     /locus_tag="A4R35_RS08395"
                     /old_locus_tag="A4R35_08345"
     CDS             12518..12760
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287422.1"
                     /locus_tag="A4R35_RS08395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08345"
                     /product="DUF2630 family protein"
                     /protein_id="WP_112428364.1"
                     /transl_table=11
                     /translation="MDDAEILQRIDELVDEEHKLLKKAEEEGLTDEERVRMKELETRLD
                     QCWDLLRQQRARRHAHLNPDEAQPRDPRIVEHYLQ"
     misc_feature    12546..12561
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.78"
                     /tool="antismash"
     gene            12919..13524
                     /locus_tag="A4R35_RS08400"
                     /old_locus_tag="A4R35_08350"
     CDS             12919..13524
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS08400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_08350"
                     /product="hypothetical protein"
                     /protein_id="WP_112428366.1"
                     /transl_table=11
                     /translation="MQVHQRPIFRQRALHHHLYGREKDILPHFMALPVPVLLWLLFGLL
                     FAAAALAWTTEIPTYTVGPGLVLDAEASSERFQLPSQGAFALIFFPWEAHQRLRPGQPV
                     QITLPATNLTLNSHIARILPGVTSPATACTYYTTANSHQASSPVTHPSVAVLVPLGQQL
                     SASIYAGTGLTAQVQTGFTRLINLLPGVGMLSGGQGAL"
     gene            13521..16082
                     /locus_tag="A4R35_RS08405"
                     /old_locus_tag="A4R35_08355"
     CDS             13521..16082
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007906106.1"
                     /locus_tag="A4R35_RS08405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08355"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_112428368.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.6e-34, bitscore:
                     116.6, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMHDYGQQGQYGQEVTQDRDYVDIFDPQEYITARRPLKRRRIRPI
                     VLQQEGDYPAIRPHLRLPVRQKPASAATPVVPAAAAEGKQIGEQQQPAAAEAQPPQQQG
                     QARPAVEAGTPSKRASKQTWSGRGWRRRRVRPLTQMNVVECGYACLAMILNYYGRPTSV
                     SELRMRHGLGRDGLSALSIVKAARSYGLRTRAISLQRTEDFHAVPLPAVVHWEFKHFIV
                     VERWTPRWVEVIDPAWGRKRLTPEEFDAGFTGIVILFEPGVHFSTEGSAHRVTLWMQVK
                     QFARQTRGTLLQVLGASLFLQLFGLLLPLLTKIVIDQILPDHMVDIMGILGLGLLLLLA
                     TQATTTILREWLLVYLRARVDIQLVLGFFEHLLTLPFSFFQQRSSGDLLQRLGSNTIIR
                     DTLSNQLISTLLDSGTVIAYLFILLWQSPIFALLTLGLGLLQVLVLLGTHRIVLDLASR
                     DLAAQGKAQGYLAETLAGMATLKAAGAEQRALERWSNLFYERLNITLRLSYLQAGINTA
                     MTILRIFSPIALLWIGAYQVLNGHLSVGTMLALNTLASAFLTPVASLVSSGQQFQILYA
                     HLERLTDVTTAEPEQDIEKAQLPPRLSGRIYVQNVSFQYGPDSPRVLKQINIRIEPGQK
                     IAIVGRTGSGKSTLGKLLLALYTPTEGEIYYDGLPLSQLNYQEVRRQFGVVLQDSQIFS
                     GSILQNITLNDPNVPYERIVKAATAAAIHEDIMRMPLGYDTPVAEGGSALSGGQRQRLC
                     LARALVNEPAILLLDEATSHLDVLTEQRVSENLRAYPCTQIIIAHRLSTIRDADLILVM
                     HDGMIIEQGTHEQLLQLNGYYAQLMRQQLEQEERQARAGAR"
     misc_feature    complement(16193..16209)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.63"
                     /tool="antismash"
     CDS             complement(16239..16427)
                     /gene="allorf_2104594_2104782"
                     /locus_tag="allorf_2104594_2104782"
                     /protein_id="allorf_2104594_2104782"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRAFPFLYLWCCCGVVRSGTPSTLWDNAAQAGGFLTPPRWPFDAR
                     LTCLNKIRSKRICYPNA"
     CDS_motif       complement(16329..16427)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRAFPFLYLWCCCGVVRSGTPSTLWDNAAQAGG"
                     /locus_tag="allorf_2104594_2104782_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16239..16328)
                     /prepeptide="core"
                     /locus_tag="allorf_2104594_2104782_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="3424.0"
                     /monoisotopic_mass="3421.8"
                     /core_sequence="FLTPPRWPFDARLTCLNKIRSKRICYPNA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRAFPFLYLWCCCGVVRSGTPSTLWDNAAQAGG"
                     /leader_location="[16328:16427](-)"
                     /alternative_weights="3442.1"
     gene            16428..16676
                     /locus_tag="A4R35_RS08410"
                     /old_locus_tag="A4R35_08360"
     CDS             16428..16676
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015192458.1"
                     /locus_tag="A4R35_RS08410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08360"
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_069803490.1"
                     /transl_table=11
                     /translation="MKFDIVRAWKDEAYRQSLSEEELSLLPESPIGEVELTDADLEAVQ
                     GGHGNTDECNNTVAVLCLQSLAVLLGLCNTNAAGGCL"
     CDS             complement(16822..17049)
                     /gene="allorf_2105177_2105404"
                     /locus_tag="allorf_2105177_2105404"
                     /protein_id="allorf_2105177_2105404"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRKDWRPLEGKERSGSGSQLNCNVRTMLQRTRSLIVLGGLTRLGA
                     SAGRQRAVDGIPWYKSSAGACSSALLFWSG"
     CDS_motif       complement(16903..17049)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRKDWRPLEGKERSGSGSQLNCNVRTMLQRTRSLIVLGGLTRLGASAGR"
                     /locus_tag="allorf_2105177_2105404_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16822..16902)
                     /prepeptide="core"
                     /locus_tag="allorf_2105177_2105404_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.90"
                     /molecular_weight="2668.0"
                     /monoisotopic_mass="2666.3"
                     /core_sequence="QRAVDGIPWYKSSAGACSSALLFWSG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRKDWRPLEGKERSGSGSQLNCNVRTMLQRTRSLIVLGGLT
                     RLGASAGR"
                     /leader_location="[16902:17049](-)"
                     /alternative_weights="2686.0"
                     /alternative_weights="2704.0"
                     /alternative_weights="2722.0"
                     /alternative_weights="2740.1"
     CDS             complement(16871..16987)
                     /gene="allorf_2105226_2105342"
                     /locus_tag="allorf_2105226_2105342"
                     /protein_id="allorf_2105226_2105342"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MQRANHAAADSIIDRSRRFDPARSKRWQAEGCGWDSLV"
     CDS_motif       complement(16961..16987)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MQRANHAAA"
                     /locus_tag="allorf_2105226_2105342_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16871..16960)
                     /prepeptide="core"
                     /locus_tag="allorf_2105226_2105342_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.60"
                     /molecular_weight="3335.7"
                     /monoisotopic_mass="3333.7"
                     /core_sequence="DSIIDRSRRFDPARSKRWQAEGCGWDSLV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MQRANHAAA"
                     /leader_location="[16960:16987](-)"
                     /alternative_weights="3353.7"
                     /alternative_weights="3371.7"
                     /alternative_weights="3389.7"
     CDS             16914..17075
                     /gene="allorf_2105269_2105430"
                     /locus_tag="allorf_2105269_2105430"
                     /protein_id="allorf_2105269_2105430"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLRAGSNLRERSMIESAAAWFARCNSVEIRYHYALYLPAVASLFA
                     PLTSILPC"
     CDS_motif       16914..16964
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLRAGSNLRERSMIESA"
                     /locus_tag="allorf_2105269_2105430_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       16965..17075
                     /prepeptide="core"
                     /locus_tag="allorf_2105269_2105430_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.70"
                     /molecular_weight="3956.6"
                     /monoisotopic_mass="3954.1"
                     /core_sequence="AAWFARCNSVEIRYHYALYLPAVASLFAPLTSILPC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLRAGSNLRERSMIESA"
                     /leader_location="[16913:16964](+)"
                     /alternative_weights="3974.6"
                     /alternative_weights="3992.7"
     gene            17243..20587
                     /locus_tag="A4R35_RS08415"
                     /old_locus_tag="A4R35_08365"
     CDS             17243..20587
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="A4R35_RS08415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08365"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_189361549.1"
                     /sec_met_domain="DUF4135 (E-value: 1.8e-117, bitscore:
                     390.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.5e-75, bitscore:
                     252.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSETTSETITASVSYPQGRWQEADWYRALTLNERLALLRTTPFPP
                     TLDALEAEALARAQQRLQRWKELPALSEEEGRFAARLALDGLDEEELLLLLGEPAEVLR
                     ARCPAPPTWLLALSEAFSPTAGPHDNGEEAETVCSSPLPGLEEGSHTRSFLHPFLPLIR
                     RARRKLAAGLRELARRSLSFSFDAERVLDLLARNIPGLLLPSISRAIVLELHVARVQGR
                     LHGATSEERFQYFLEQLSEREATLDFLQEYVVLARLVTETLERWVCRSLELLERLTDDW
                     PLICSTFLTNGEAGSLCEIHQGAGDLHRNGQSVILLRWDSGFRLVYKPRSLAIDRHFQE
                     LLAWMNERGFSPPLRTLTVLDRGHYGWVEFVQARHCSSREEIERFYLRQGAYLALLYAL
                     EASDFHAENIIASGEYPMLIDLETLFLPQINPEVLQAQGAPGLEAIGHSVLRVGLLPQR
                     LWSNQEGEGIDMSGLGGQPGQLSPRPVPTWKGTGTDEMRLTNERVELPVKENRPRLNDQ
                     DINVLDYSQCIIEGFTRAYRLLMAQRSELLETYLPRFADAEVRCVLRPTRIYTQLLVDS
                     LHPNVLRDALDRDRLFDRLWATTERLPYLVPLIPAERRDLWRGDVPVFTTTAASTDLFT
                     SEGERLSAFFSEPGLEVVRRRLAELSELDLEKQLWIIRASFTSMIDATTPQSYTRLELH
                     PARTSPTLERLLAAASAIGNRLRQFALYQGEYVGWLGVTPVNDREWHLLPADGDLYNGL
                     AGIALFLAYLGHLTGEQRHTELARMALRTIQQQIMRRKYFPRAYGIGAFNGLGSLIYLF
                     CHLGALWSEPALYRQAEELVPSLLAKVEQDQVYDVIGGAAGAIAALLCLQRVSPSPETL
                     AAAVRCGEHLLSHAQPQAQGGCGWPTTRQPVALAGFAHGNAGIALYLMQLAQVSGETRF
                     AEMARAALAYERTLFSPSRQNWLDLRQRPPSSGVNQPVGEKYMVAWCHGAPGVALSRLA
                     LLSLLDDQELTEEIKAGLRTTLTQGFGLNHSLCHGDLGNLDILITAARLLPGETFAEHI
                     PRIAAALLENMEHQGWVCGVPFGVETPGLMTGLAGTGFALLRLASPERVPSVLLLAPPM
                     APSTPAV"
     gene            20872..21321
                     /locus_tag="A4R35_RS08420"
                     /old_locus_tag="A4R35_08370"
     CDS             20872..21321
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS08420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_08370"
                     /product="hypothetical protein"
                     /protein_id="WP_112428372.1"
                     /transl_table=11
                     /translation="MLDWTLTASLLLWGLIAFLLTLYWITRVERDSGRLRPRWSEIFTR
                     FPKFVIGFIPASLVMAVLINLHLLQSSPAMINDLNALRTLALYPGRREHRSGLPARELQ
                     IGSSPSTVSQLAEQGQRACGQSSPYVRCPLLAPRDPGSVSNDGRG"
     CDS             complement(21424..21588)
                     /gene="allorf_2109779_2109943"
                     /locus_tag="allorf_2109779_2109943"
                     /protein_id="allorf_2109779_2109943"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLAVSLAAFLSLSSCLAKCSWLQSRCGGTVYAPVSKTGPARVVSS
                     SLTTGTSIP"
     CDS_motif       complement(21565..21588)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLAVSLAA"
                     /locus_tag="allorf_2109779_2109943_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21424..21564)
                     /prepeptide="core"
                     /locus_tag="allorf_2109779_2109943_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.30"
                     /molecular_weight="4435.1"
                     /monoisotopic_mass="4432.4"
                     /core_sequence="FLSLSSCLAKCSWLQSRCGGTVYAPVSKTGPARVVSSSLTTGT
                     SIP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLAVSLAA"
                     /leader_location="[21564:21588](-)"
                     /alternative_weights="4453.1"
                     /alternative_weights="4471.1"
                     /alternative_weights="4489.2"
                     /alternative_weights="4507.2"
                     /alternative_weights="4525.2"
                     /alternative_weights="4543.2"
                     /alternative_weights="4561.2"
                     /alternative_weights="4579.3"
                     /alternative_weights="4597.3"
                     /alternative_weights="4615.3"
                     /alternative_weights="4633.3"
                     /alternative_weights="4651.3"
     CDS             21431..21637
                     /gene="allorf_2109786_2109992"
                     /locus_tag="allorf_2109786_2109992"
                     /protein_id="allorf_2109786_2109992"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MEVPVVRLELTTLAGPVFETGAYTVPPHRLWSQEHFAKQLLRLRK
                     AARLTASIPVLRSGSFQYTKVCD"
     CDS_motif       21431..21478
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEVPVVRLELTTLAGP"
                     /locus_tag="allorf_2109786_2109992_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       21479..21637
                     /prepeptide="core"
                     /locus_tag="allorf_2109786_2109992_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.40"
                     /molecular_weight="5830.7"
                     /monoisotopic_mass="5827.2"
                     /core_sequence="VFETGAYTVPPHRLWSQEHFAKQLLRLRKAARLTASIPVLRSG
                     SFQYTKVCD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEVPVVRLELTTLAGP"
                     /leader_location="[21430:21478](+)"
                     /alternative_weights="5848.7"
                     /alternative_weights="5866.7"
                     /alternative_weights="5884.8"
                     /alternative_weights="5902.8"
                     /alternative_weights="5920.8"
                     /alternative_weights="5938.8"
                     /alternative_weights="5956.8"
     tRNA            complement(21438..21518)
                     /anticodon=(pos:complement(2109838..2109840),aa:Leu,
                     seq:caa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="A4R35_RS08425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="A4R35_08375"
                     /product="tRNA-Leu"
     gene            complement(21438..21518)
                     /locus_tag="A4R35_RS08425"
                     /old_locus_tag="A4R35_08375"
     CDS             21468..21578
                     /gene="allorf_2109823_2109933"
                     /locus_tag="allorf_2109823_2109933"
                     /protein_id="allorf_2109823_2109933"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRDLFLRQARIPFRHTGSGARSTLPSSCSDSEKLPG"
     CDS_motif       21468..21527
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRDLFLRQARIPFRHTGSGA"
                     /locus_tag="allorf_2109823_2109933_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       21528..21578
                     /prepeptide="core"
                     /locus_tag="allorf_2109823_2109933_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.70"
                     /molecular_weight="1555.7"
                     /monoisotopic_mass="1554.8"
                     /core_sequence="RSTLPSSCSDSEKLPG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRDLFLRQARIPFRHTGSGA"
                     /leader_location="[21467:21527](+)"
                     /alternative_weights="1573.7"
                     /alternative_weights="1591.7"
                     /alternative_weights="1609.7"
                     /alternative_weights="1627.8"
                     /alternative_weights="1645.8"
     gene            complement(21693..22652)
                     /locus_tag="A4R35_RS08430"
                     /old_locus_tag="A4R35_08380"
     CDS             complement(21693..22652)
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007909322.1"
                     /locus_tag="A4R35_RS08430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08380"
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit alpha"
                     /protein_id="WP_112428374.1"
                     /transl_table=11
                     /translation="MVYDLEFEKPLAELEKRIASLQRKGERLRPEEHVQLQEYERELRR
                     RTEEIYRSLTAWQTVQVARHKDRPYTADFIHLMCEEFFELHGDRRVGDDQAIIGGPALF
                     NGETVMIIGHEKGRGMREKMYHNNGMPHPEGYHKAIRLMEQAEKFGYPVICLVDTQGAF
                     LGLEDEERGQGSAIAASLYAMARLRVPIIAAVIGEGGSGGALAISVADRLLMLEYSIYT
                     VAAPEAAASIIWRDKVYAPQTAEAMRISARELYALGLIDELVPEPLGGAHHNHRLAAEN
                     LKMALIHHLQELRQIPVDRLVQMRYEKYRAVGPFGFAS"
     gene            complement(22636..23619)
                     /gene="accD"
                     /locus_tag="A4R35_RS08435"
                     /old_locus_tag="A4R35_08385"
     CDS             complement(22636..23619)
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012872318.1"
                     /locus_tag="A4R35_RS08435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08385"
                     /product="acetyl-CoA carboxylase, carboxyltransferase
                     subunit beta"
                     /protein_id="WP_112428376.1"
                     /transl_table=11
                     /translation="MAKEAAGSSGGPQPERPSGPGVAPDNLMVKCPKCKEILYSRDWEK
                     NLKVCSRCNYHFRLTAHERVSLLLDPGSFVELDAAMVSVDPLNFVSRSQSYAAKLQEER
                     AKVGLNEAAIRGYGTIEGLPLSLAVMDFRFIGGSMGSVVGEKVTRAIELGLERRWPVLV
                     VSTSGGARMQEGFYSLLQMAKTVAALARLSEARIPYFSLITDPTTGGVTASFAMLGDVI
                     LAEPGALIAFAGPRVIEQFMHVKLPEGTVNSEFVLQHGMIDAVVHRRELRATLARLLRL
                     YKVPEAERAQQSAPAAQSSVEAATLLSRQPAQSRAEVGGGQDGLRS"
     gene            complement(23703..24725)
                     /gene="ftsY"
                     /locus_tag="A4R35_RS08440"
                     /old_locus_tag="A4R35_08390"
     CDS             complement(23703..24725)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005047 - signal recognition particle
                     binding [Evidence IEA]"
                     /GO_process="GO:0006614 - SRP-dependent cotranslational
                     protein targeting to membrane [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="ftsY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012257595.1"
                     /locus_tag="A4R35_RS08440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08390"
                     /product="signal recognition particle-docking protein FtsY"
                     /protein_id="WP_112428378.1"
                     /transl_table=11
                     /translation="MLNRFFGRKPKEEEEAARQEESVAGQERKGADSAFEQRLSFLKAS
                     LSRTRRLFGRVQESFRQDEPVTDTFWDELEESLIEADVGASTTTWLLERLRERAEQERL
                     RTTSQVRRALREELLTLLGKAAPLHFATQAPLTVMLIIGVNGSGKTTTVAKLAYRLKQE
                     GHRVILAAADTFRAGAIEQLKAWGERIDVPVISQNPGSDPGAVVYDAIQAGLSRGHDVL
                     LVDTAGRLHTKFNLMEELKKIGKVVQKFLPEGPQELLIVIDATTGQNALLQARKFAEDV
                     GLTGVIITKMDSTAKGGFAFAVADDLGVPIKFLGTGEKVTDLTPFDPESFVEALLAQDE
                     "
     CDS             complement(24759..24986)
                     /gene="allorf_2113114_2113341"
                     /locus_tag="allorf_2113114_2113341"
                     /protein_id="allorf_2113114_2113341"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKADGWGRQEASEVCQSAGLAPSCCLPGDRIAGGQRLPPLLFPDG
                     GRVITLVDLGATRRGAGGRRAQCAVGERLG"
     CDS_motif       complement(24885..24986)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKADGWGRQEASEVCQSAGLAPSCCLPGDRIAGG"
                     /locus_tag="allorf_2113114_2113341_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(24759..24884)
                     /prepeptide="core"
                     /locus_tag="allorf_2113114_2113341_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.60"
                     /molecular_weight="4264.9"
                     /monoisotopic_mass="4262.4"
                     /core_sequence="QRLPPLLFPDGGRVITLVDLGATRRGAGGRRAQCAVGERLG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKADGWGRQEASEVCQSAGLAPSCCLPGDRIAGG"
                     /leader_location="[24884:24986](-)"
                     /alternative_weights="4282.9"
     CDS             complement(25027..25266)
                     /gene="allorf_2113382_2113621"
                     /locus_tag="allorf_2113382_2113621"
                     /protein_id="allorf_2113382_2113621"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSRPSLTSSPHLLSSSAAFCPANPPALGSLPCHVRPACGCSEVCL
                     LRRRIARQVRAWLLSLPVTLFNGLLPFSLSGERA"
     CDS_motif       complement(25213..25266)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSRPSLTSSPHLLSSSAA"
                     /locus_tag="allorf_2113382_2113621_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(25027..25212)
                     /prepeptide="core"
                     /locus_tag="allorf_2113382_2113621_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.10"
                     /molecular_weight="6523.7"
                     /monoisotopic_mass="6519.5"
                     /core_sequence="FCPANPPALGSLPCHVRPACGCSEVCLLRRRIARQVRAWLLSL
                     PVTLFNGLLPFSLSGERA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSRPSLTSSPHLLSSSAA"
                     /leader_location="[25212:25266](-)"
                     /alternative_weights="6541.7"
     CDS             25108..25254
                     /gene="allorf_2113463_2113609"
                     /locus_tag="allorf_2113463_2113609"
                     /protein_id="allorf_2113463_2113609"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MPCYAPSQQTNLATAASRPYVARKRAKSWGISRAESGGRREQMGR
                     TCK"
     CDS_motif       25108..25221
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MPCYAPSQQTNLATAASRPYVARKRAKSWGISRAESGG"
                     /locus_tag="allorf_2113463_2113609_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       25222..25254
                     /prepeptide="core"
                     /locus_tag="allorf_2113463_2113609_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.10"
                     /molecular_weight="1246.5"
                     /monoisotopic_mass="1245.6"
                     /core_sequence="RREQMGRTCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPCYAPSQQTNLATAASRPYVARKRAKSWGISRAESGG"
                     /leader_location="[25107:25221](+)"
     CDS             25312..25380
                     /gene="allorf_2113667_2113735"
                     /locus_tag="allorf_2113667_2113735"
                     /protein_id="allorf_2113667_2113735"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRAEAEKASGRARASCQRLFSS"
     CDS_motif       25312..25338
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRAEAEKAS"
                     /locus_tag="allorf_2113667_2113735_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       25339..25380
                     /prepeptide="core"
                     /locus_tag="allorf_2113667_2113735_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="1384.6"
                     /monoisotopic_mass="1383.7"
                     /core_sequence="GRARASCQRLFSS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRAEAEKAS"
                     /leader_location="[25311:25338](+)"
                     /alternative_weights="1402.6"
                     /alternative_weights="1420.6"
     gene            complement(25522..25737)
                     /locus_tag="A4R35_RS08445"
                     /old_locus_tag="A4R35_08395"
     CDS             complement(25522..25737)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007909317.1"
                     /locus_tag="A4R35_RS08445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08395"
                     /product="hypothetical protein"
                     /protein_id="WP_052888209.1"
                     /transl_table=11
                     /translation="MEFSFPRCRKCSEGDLVPLSDFGSQGASIEYKAWVCTNPSCLYNI
                     KIRNGDIIINEPISDGSLHQYRGSRS"
     misc_feature    26557..26570
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.15"
                     /tool="antismash"
     gene            26710..27795
                     /locus_tag="A4R35_RS08450"
                     /old_locus_tag="A4R35_08400"
     CDS             26710..27795
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007909295.1"
                     /locus_tag="A4R35_RS08450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08400"
                     /product="RNA polymerase sigma factor RpoD/SigA"
                     /protein_id="WP_223258253.1"
                     /transl_table=11
                     /translation="MGVRGNKAETHLGLLEVDDMTSAAQRPKKRAGQPRHPGKRSRQAA
                     AAFDEPSPSDLDLESEEAVLAELGEEEDEDEDGGETSERSAIDDTVKLYLKEIGSYPLL
                     TAEQELMLAERVAQGDLRARQRLIESNLRLVVSIAKRYTNQGLPLLDMIQEGNIGLMRA
                     AQKFDYRRGFRFSTYATWWIRQAISRAIAEHSRTIHIPVHVVELIYRIKRVARRIYQEQ
                     GVEPLPEELAAEVGLPKERIVELLNISEQPVSLDAPVADDEQYHLADTLEDPSMMAPED
                     SEARQRLHDHLQQAMEILNPRERTILEMRYGLQDGCSHSLDEVSARFKLTRERIRQIEV
                     KALRKLRYPERYYGLREFASL"
     gene            complement(27932..29048)
                     /gene="prfB"
                     /locus_tag="A4R35_RS08455"
                     /old_locus_tag="A4R35_08405"
     CDS             complement(join(27932..28981,28983..29048))
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0016149 - translation release factor
                     activity, codon specific [Evidence IEA]"
                     /GO_process="GO:0006415 - translational termination
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="prfB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012874700.1"
                     /locus_tag="A4R35_RS08455"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="A4R35_08405"
                     /product="peptide chain release factor 2"
                     /protein_id="WP_399356828.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MSELTSRIERLQWRVHETMVRLDLAHKREQIAALEAETLQPDFWS
                     DNRRAQSHMQHLTALREEVETWERLEKQLQDLQELAQLLGEEPDADLEAEVTRSLNAVE
                     QEVEQLELALLFSGEHDERDAILSIHAGSGGVDAQDWAEMLLRMYLRWAERHRFRTQIY
                     DYNEGEEAGIKSATVEISGRYAYGHLRSEIGTHRLIRLSPFDAAHRRHTSFARVEVIPD
                     IEDTIEVTIRPEDLDIDTYRSTGAGGQHVNKTDSAVRIRHIPTGIVVTCQNERSQIQNR
                     EVAMRILRARLYELERRKREEEVARLKGEYVQADFGTQIRTVTLHPYTIVKDHRTGYET
                     SDTQGYLAGDLDPFIRAYLQMQAHQAVSAQR"
     gene            complement(29146..29664)
                     /locus_tag="A4R35_RS08460"
                     /old_locus_tag="A4R35_08410"
     CDS             complement(29146..29664)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009222909.1"
                     /locus_tag="A4R35_RS08460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_08410"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_112428380.1"
                     /transl_table=11
                     /translation="MSTVVHIREITPDDAEAFLTLCKRLDQETRFMLLEPDERTLTPDE
                     QRQALENLLATGRSTIFVAEAGQSGELVGYLALEGGTYRRERQRATLVIGILQAFTGQG
                     IGSRLFQVMESWARQRSFHRLELTVMVHNQRALALYLRQGFMVEGLRRQALVVDGQSVD
                     EYYMAKLLQ"
ORIGIN
        1 cgcggcacgt agacgagcct ggctgccaga acaatcgctc agatcctcca cccctacctc
       61 tagctcagct aaagccccga gttcgttgag caccgccacc gcccaacgca cgcgactcag
      121 cggctcgctc gaccgacttt gctcattggc tcgccagcgc tgtgccaggc gctggccgat
      181 agtccgcagg agtcgctcta gctccgcggc agggagctgc tcggtcagta actcaaggag
      241 cgcatcgagg gttggcaggt aggcacgcgg aaagagagga tcggcagccg gagccagctc
      301 gtaaaggtaa gccggcttcc cttgagcagc acgccgctct ccccgttgga caacaaagcc
      361 atcacgctcc agcgccgcca agtgagcacg cacggcatta tcggtcagcc ctagctcccg
      421 ggccaattct tcaactgtag ccccctggcg agagagcaaa gccacaatgc gcccgcgcgt
      481 gctcctgaaa aagcgccgct gcgcctgatt gccagtcatc ggtcttgcac ttcctgatcg
      541 agaggaaaaa caattagcgc ttgctttgcc tcagtttaac agagagccag ccttatgtca
      601 ataaattctt tgactttctt gactttcccg agcgagtatg gtatatccaa aagagggaga
      661 gagtcctgga agctgcccga tgcgctagtg gacggatcgg gcaggctttt ttagccaaag
      721 cacaactgcc tgctatctgc tgacgcctgt ttgcttcctg tacagcagga gcggctaacc
      781 agagacggag gggcaatggc gagcaacgcc agccggtcga ggcctggcca gcgcacacgc
      841 tgacgtggtc aaggcccact gtatgcggtc ttgtcagcca ttgccccccc gtttttccgt
      901 gcacagagac gagaggcgtt tgacctggca acatgcagca aggacgaggg ggaaggccgc
      961 tcttgaggcc agagttggag catgggcagg ttgtcagccc ttgtgaagag aagagaagag
     1021 acgaaggaga gcaccatgag cgacacgacg catgagccgg tcccgtcaac gaccaacatc
     1081 tggcagtctt tcgccgaccg ctttggcgac agtctgcagg ctctggcccg cacgctgact
     1141 ggaggcacgc agaagccacc acgcctcctg aaaagcttac tcagcggcac ctttggaggt
     1201 catcccctgc acccggccat caccgatatc ccgatcggcg cctggaccct gaccgccatt
     1261 ctcgacatta tctggctggc cgcaccagct ggcaatagct gggccgcgcg cggggcgctg
     1321 gtcggagcca tcgttgggtt gatcgctgct ctgggagcgc tgtttaccgg tctggccgac
     1381 tggagcgata cctatggagc tgagcgaacg gtcggcttct atcatggctt gctcaacacg
     1441 gcggcttttc tcctctatct ggtctcattg atcctgcgcc tgatctctcc tctgaacgaa
     1501 agcatcgccg ccgccgtgct cggcttcatc ggcttcgtgg ctattctggt ggcgggctat
     1561 ctgggcggag acatggtctt tgtgaagggc accaacgtta accatactgc ctgggaggcg
     1621 gcaggcgagg acttcgagcc ggtccttccg gcaagcaatg tcgaggaggg acacctctat
     1681 cgcgtaacag tagccggtgt gcccgtggta ctgctccgtc gtggcgagca gtactatgca
     1741 atttcagcaa cctgccccca tgctggggga cctctggacg aaggaacgct ggatggggat
     1801 gtggtggaat gtccctggca tggctcacgc ttttgcgtgc gcgatgggcg cgtgctgact
     1861 ggcccggcaa ccgtgccggc tccgcgctat gcggtacgcg ttcgcaatgg ccaggttgaa
     1921 ctacgccgtt tgggtgggca ctgatcagag agacaggagc cttctgcgag caacccctga
     1981 tgccaggata gtccccggtg ccattttcca cacaaaagga cccgagagag ataccctcgg
     2041 gtccagcttg tttctgtggt cagatcaccg cacaaccgcc gctgatccga cccgctttac
     2101 gacgcggcag tcgcgggcgt gttgagcaac tcgtccagcg tattcttctt gacacgatag
     2161 acttcgcgct tgcccttgtg cggcaaggta atggcctgca gggcaccggt cttgatccag
     2221 cggcgcaccg tggtgtcatc aacacgcagg cgcttcgcta cctcgctgac agtgagcagc
     2281 tctgtcgtat actcttcacg agaatcgcgc tcgcgatcca caactgcact ttcccgacga
     2341 gccataggtt tccctctcct ctctactgaa ttcgatcgga ttacagtccc aggcagttcg
     2401 cctggagcgt tctatcattt ccagctaata tgagtaaaac actcctctat taagaggaac
     2461 tgtgaattag ctgaaatttc gctgagaatt tggaactccc gatctgcccg tcccgccagg
     2521 gaagcggctc agtttgcctg aaaaggaaga gacagaacct cagcagcttc cccgcttggg
     2581 gccgggaaat tgagactttt cacttctccg attttataat agcacatttc cgatctatta
     2641 tccaatccac tggtaataac aacggggaag ccggataatc ttcccggcca gcgaacagcc
     2701 gtatctagag aagagagaag cggggagttg agggagtata gaagcaggtg atcaacccgg
     2761 caaagcagag gagaagcggc acaggccatc tgagcgttgc gcccattgat gttgatccag
     2821 cacggttcct gatcagaagg attgatctct caaaaggatt gatctctcaa tgggaacgaa
     2881 aggaggagaa ggaggagagg taaccactcc ccttgcccag aagcaggagc tgctgggaag
     2941 cgtgttcccc ggctctctag ctgtcaagcc aacaggtctg ccgcagctgt gaggtctccc
     3001 tccatgcagc ccgacatagg aggatggaca ttcgaagatc tgttcgagcg ccagagcggt
     3061 gcccgcgtca gggccgcctt ccgctggcct ggcttactca agaggcgtta ctacagcggc
     3121 atagccgccc caccactgga ggaactgctc ccggctgagg acacggcgat tccaggccga
     3181 ggagtcggcc agatagaccg acgttgcatc gccgccgagc acgacgagca aatggccgcc
     3241 agcatagcga tctggtggga agcttacgat cacaggggca ccattgttgg ccacggccag
     3301 cagctgctcc agggaccagt gctcacccca ctcggtgcga aagacaaagt gggccgcagt
     3361 gattgcaata ccatctggcg ataccaggcc cagctccggc gtgatttgcc ccagagctgc
     3421 ctcgacgtgc agcacgtcgc tgatgcgata gtgccggcca taggcattga agacctccgt
     3481 catggcggct gctgaacatg cagaataggc ccaggtgtca tattcttctt gagaagcata
     3541 ctgggcagga tcaagctggg agatacgcac aagactgcgc gaggcgttga agccatgagg
     3601 cagggtctgg agatcaagtg tctgaccgtg attgttgcgg aaaaaggtga gcgccgcgtt
     3661 cagcgtcagc tgtccaccat cggccagagc actggtcatc gagagcgcca gaagaaccat
     3721 taccagcagc agcagcgaga gaatcacacg ccaacgccga taccagggcg ccgggatcgt
     3781 ctgagcgaac cagggcttcc cctcctggcc gtcttgtgcc cgctgcagaa ggcgggcagt
     3841 acgagcggtc aagcttgctt gctctcctga agaggagacg aggagagcac ttgccagccc
     3901 ttcacgccgc aaccagcgct caagccagct tccacggcgc caaagactca gccccagcat
     3961 gagcaggagc agcgcgctcg ccagcaccat aaaggggacc acagagcaac ctcccggttc
     4021 ttcatctcca taaacacatc aacatcattt accagaagta tcccgggagt tgagggcttc
     4081 cgtcaaatca cccccacaat agtaccatat gaagcatgct ggtgcagatt aagacgcgcg
     4141 ggagcctggc ggtatagagg tcaagatggc tactggacca gcggcggctc ttcgcgagga
     4201 tactcaacct gcggctcttc gtactgcggt tgaggacgcc tcgccatcgg ttgagcctgc
     4261 tgtggctgtg gctcggcagc ctcgctggag cgcggacccg tctgggcgcg ataaccctgg
     4321 tggtagcgcc gctcaggctc tcctggctgg ctgcccgggt aagaggtctg gtaggtatcc
     4381 attggtcccg gcggcgcctg cggcggctgc tgctgccatt gccacatgcc accactcatc
     4441 ggccagctgc gccccgcccc cggcccctgc tcagcaaaga gcacagagag ggcccaggcc
     4501 agcaaggcga tgaagaagat gctcagcata atgccgaaca tcgcgctacc ccagccccac
     4561 caccaatgtg ccggacccag gaaaaacaga ggaataaacc accagaaaaa ccaaccccgg
     4621 tggcgcccaa aatggtttcg tcggtacatt gtcgatcctc tctatctctc aacaagcgcc
     4681 cgaaaggcgg aacttctatt caagtgcgtc cttttcctgc agcttctgat cttcattgcg
     4741 ccattctctc aaagacagag tataacagat agctatcgct gtcaaggaag aggagcatcc
     4801 tcttctccct tctctcttac agaggagaac gctggcaggt tgcataactc caagagtccg
     4861 cctgtttctc tctccctcca cggccacggc ctgggcgctg gccgaaagtc ctagcctggc
     4921 gtcacggctc gtccgacatt cgacaggtca gaacaaatat tctataatct ccagtagaaa
     4981 tagaaagaga gcagcgctgg cgaggatgga aggacgggga aagcgccaaa gagagcagag
     5041 gatggccagt atgatcacca tcttcacccg tcgaggcaaa cggatcgaga ttctctcaca
     5101 gagtgaacta cgccatccgc gcctgacagg caaccgggtg cgcgccttct gtccgattca
     5161 cggcagtgat catcaacgct cgctctcgat cgacccagcc agcggctggg gctattgctt
     5221 taacgcctcc tgtcaagcca aagtcctgat agctgaatgg aatccaggtg cagcccacca
     5281 tctcctggca gccaacgcca gcggtagtcg gggacaggca agcgctcagg aagggtcaac
     5341 aggaagccag acctcctcgc cctttcactg gctgagccag ccagaagaac ggcctagtag
     5401 cgtcagcgtt ctgaaccgct ggcaagaaga agagcggcgt atattgcaag ccctggaacc
     5461 caccatgcaa gcggcgttga agtccagcag cctggggcgc gcctacctgc gcgagcgggc
     5521 cattcctctg gagatcgctc ttactggtgg cgttggcctc ctgacgccaa cgatcattac
     5581 tcgcctgacg cactctaaac agcgacgcct cctgcaacgc tggagcgggc ggttgatttt
     5641 tcctcttcaa gcagaaacca caagaggcta tatcgggcgc acactcgtgg gatggcagcc
     5701 tggaatggat gaaaacgctc ataagcagct cttagagcgt cccggtcgcc cacagcgctg
     5761 gatcaaaacc aatcctgccg gctgttttag cctgccacga gagcagcttg cccctcagct
     5821 catcgtggtt gaaggaacct ttgatcgtct ggccttgctg gcggctggcc ttcgagcgaa
     5881 cgaagtggtc gccctggctg gcaccgcact gcccctcagc tggctccctg cccaggttcg
     5941 cagcgtgctg ctggccctcg atggcgatga gggaggacgc gaggccacaa ctcgtctcag
     6001 cgcgcaactc cgcgagcaag ggcgggcagt cagctgttgc ctgatgcccc tggacggaca
     6061 gggtaaggac tggaatgagc gctggcgcct ggctggccgt gcaggcttgc agccgctact
     6121 ggatagctat cgccgtctgt attgacttgt ctctacgcgc gacatagact tacttacagc
     6181 agaaaaagaa caaccaccag cgcgggccga cctgtctccc tgcctcgaag gtcaagggcc
     6241 ccgaaagccc atctgtttga aaggagcacg agccgatgag tacctcgttc aacgccgaac
     6301 agcccctgtg ggagccttca gaggaactaa aagagcaagc caatattacg cactatatgc
     6361 gctggcttgc cgagcagcgc ggcaagcaat tcgccagccg ccatgagctt tgggagtggt
     6421 cggtcgccga ccttgaaggc ttctggtcct cgctctggga ctattttcag atccaggcca
     6481 gccagccata tactcaggtg ctggccagcc gcagcatgcc tggcgccaga tggttcccag
     6541 gcgccgagct gaactacgct cagcatgtct tccgccaggc cagtgctgag catccggcca
     6601 tcatcttccg ctccgaacgc gaaccgtggc gcacgctctc ctggaaggag ctggagcagg
     6661 cagtgggagc cgtggcccag gccctgcgtc agctcggcat caagcgcggc gaccgggtcg
     6721 tggcctattt gcctaatatt ccggagacag tgatcgcctt cctcgcctgc gccagccttg
     6781 gcgctatctg gtctagctgc tcgcccgact ttggcaccag cagcgtcgtt gaccgttttc
     6841 agcagattga gccacgggtg ctcttcgccg tcgatggcta ccagtacaat gggcgctcct
     6901 tcgaccgcag gggagtgctg gctgagcttc agacagccct gcctacgctc gaacatacca
     6961 ttatcattcc ctacctgcac gccacccctg aggaagccag ggccggcctc agcaagacca
     7021 ttccctggag cagtctgctc gcccaaccag cccccctcac cttcgagcag gttccctttg
     7081 agcatccgct ctgggtgctc tattcctcgg gaaccactgg acttcccaag gccatcgtgc
     7141 agggtcaggg cggcatcctg ctggaacatc tcaaagtgct ctcactggag agcaatctta
     7201 agccgggcga ccgcttcttc tggttcactt ccacaggctg gatgatgtgg aacttcctgg
     7261 tgagcggcct gctggtcggg gccacgatct tactctacga tggcgccccc ggctatcccg
     7321 atatgaatac cctctggcgc tttgctcagg atagcggtat gaaccttttc gggaccagcg
     7381 ccgcttacat ctctggctgc atgaaggctg gtatcgagcc aggaaaggag ttcgatctca
     7441 gccagctccg ctgcattggt tccactggct cccccctgcc cccagaaggc ttccgctgga
     7501 tttatgagca cgtcaagcgc gatgtctggc tggcctcggt cagcggcggc accgatgtct
     7561 gctcagcctt cgtcggcggc tgtgtcctgc ttcccgtcta tgcaggtgaa atccagtgcc
     7621 gtgcactcgg cgcgcgtgtc gaggccttcg acgaagaggg acgctcttta atcgatgagg
     7681 tcggcgaact ggtggtcacg gcgccgatgc cctcaatgcc actcttcttc tggaacgatc
     7741 cagataatcg ccgctaccgt gaaagttact tcgaaatgta cccgggcgtc tggcgccacg
     7801 gtgactggat caagatcacc ccacgcgggg gcgccatcat ctacggtcgc tcagattcga
     7861 cgatcaaccg ccaggggatt cgcatgggaa gcagcgagat ctatcgcgtc gtcgagagct
     7921 tccccgaggt gctcgatagc ctggtcgtcg gagtagaacg ccccggtggc ggctattacc
     7981 tgcccctgtt cgttgtgctg cgcgagggag tccgcctcga tgaagacctt cagcgccgtt
     8041 tgaaggaggc tctgcgccgc gagatctcgc cgcatcatgt gcctgacgag atcattgcca
     8101 ttcccgaggt gccccgcaca ctgagcggca agaaaatgga ggtgccagtc aagaagctgc
     8161 tcctgggtat gcctctggag aaggcggcca gccccgacgc gatgagcaat cctcaggcga
     8221 tccagttctt cgttgacttc gcccgccaac tccaggctcg ctcgggcagt acgccctagg
     8281 ctccgccagc tccgctgctc ttcatctcgc ttcatagatg gatatacatt tattatttat
     8341 tggggttggt tataatggag gtgtagcttt gcccagcgca caagcgaagc aaggccgaag
     8401 agcgtgaggc actggtcgac gggccgtcca ccagttcgtc ggcggttatc tcgacggatg
     8461 gactggaggg catgctgacc ggtaagagag gaggcggggt gaggagcgga gggctatgga
     8521 tgagcatggt cagagcgtcc tccgcagagg ggtgcttgag aagcgtactg cgctggaact
     8581 ctgtgcagcc tgaaaaggga aaggagcaac atgcaagaaa agccccggtg ggtcaagccg
     8641 tccttcgaag tcattgcggt gagccttgag tgcactgcct atgcaggtgt actcctgttg
     8701 tttgaacctc aaaagagaca gtagtaccgc gctaggcagg gagagagcag gcagagggcg
     8761 ctaatggagg aagggtgagc cgtagaggga gggggcggag actgagcagg tcctgcctcc
     8821 tccctgctcc ccgtctggct gcggtcgatg ccttgtctgg ttctgctttg ttggcctggg
     8881 ctgcggaaag tgagcaaaca cctccaagga ttgaaatgga agagagaggc agcccgttca
     8941 gggattagaa aaacaagaaa aatgttggtg cgtctgctcg gtacagcagc aggaggaggc
     9001 ttcccgcagt ggaactgcaa ttgctcgaac tgccagggtc tccgtgcggg agagctgaag
     9061 gcgaaggcac gcacacagtc ttgtgtggcg gtgagcgccg acggcgagcg ctggtttcta
     9121 ctcaatgcct ctcctgatct gcgcattcag cttgaaggtt ttccacctct ctggccccca
     9181 gcctcttgca ggcgcggcac gccgatcgag gccattttgc tgaccgatgc cgatctcgac
     9241 cataccctcg gcctcctgct ccttcgggag cgttcagctt tgactatcta tgcgcctgtg
     9301 gcagttcaac aagccctgcg ccagggactg gtcctaccgc agttgctcgc tcattactgc
     9361 tgcgtcgagt ggcgtgaacc cgccgaagag ctggctcctc tgcccactgc ggcgggccat
     9421 gagagcggcc ttctctacca ggctatcccc ctgaccggca agcctccgcg ctacctcgac
     9481 ctcgcagagg ccagtacgct cgcaaccggc tccccgttcc gcgttggcta ttatctcacg
     9541 gatgtgcgga ctggcggacg tctgcttttc ctaccagggc tagcccgaca agaggagcag
     9601 ctgcagccct acctgcgagc ctgcgatgcc attctccttg acggcacctt ttggagcgag
     9661 catgagctgc aggagcaggg tcttgtccag gcaacagcaa gcagcatggg ccatctccca
     9721 atcagcgggc cagcaggcag tctggcctgg ttagcgcagc ttcctattcc ctatcgcatc
     9781 tatacccata tcaacaacac caatccggtc ctggtcgagg attcgcccca gtatgccacc
     9841 gtgtacgctg ccggagtcat catcggctgg gacggcctag aactgcagct atgattgcac
     9901 acgccctcac ctcgcctgcc gctgaccaga ggatcgcagg gcagataagc aatcgagcca
     9961 gcaagtaagc tggctggcaa gagcgaagag aggagctact atgagcacag tgattcttga
    10021 gccttgggat cacgagacct ttgtcgccca actgcgagct gttggcatga ctcgctatca
    10081 tcatctccat ccttttcatc aagctatgaa tcgaggcgcc ctttctcctg agcagatccg
    10141 cgcctggatc gtgaaccgtt tctattatca gcagcacatt ccgatgaaag atgcggcaat
    10201 ccttgccaat tgtcctctcc cagaggttcg ccggctctgg cttcaccgca tcagcgatca
    10261 cgatggcgag cacgaggatg agggcggcat tgcagcctgg ctgaagctgg ccgaagcaag
    10321 cggcctctca cgggaagagg tgctgagcgg acggcatgtg ctgcctggcg tccgcttcgc
    10381 cgtcgaagcc tatgtgactt tcgcccgtca gcagccgtgg cctctggccg tagcctcctc
    10441 gttgactgag ctgttctctc ccgacctgat gagcgagcgc ctggccgcct ttgagcgcta
    10501 ctacacctgg attagcccgg aggggttgac ctatttccgg gcccgtttgc agcaggcacc
    10561 acgcgacgcg gcacaggcac tggagctgac tgtgcgctac tgcacaacgc gccagcttca
    10621 ggagggtgct gtccaggcgc tcgcttttaa atgtgatgtg ctctggagca tgctcgacgc
    10681 cctgcagttc gcctacggcc ccttgcctgg cgagccggcg cagacagcgg ccagcaccag
    10741 cgcccccact cccgccccac aggaaggtcg cctatgagca cgcctggcga aggcagtttc
    10801 ccacctccga aggtgctgcg tccccgcctg cttcccaggg cacggctgga aatcgatcgt
    10861 ctcagccagc gacctattct gctctatccc gaaggagtga tgatgctcaa tgagaccgca
    10921 gctgctatct tgcagctctg caacggcgag tatacgctgg ccgatatcct tcgagagctg
    10981 gcgaaccgtt acgaggccag tcccgagcag ctgcaggatg atgtctatga atacctttgt
    11041 tcgctgcggg accagaatct cgtcgcctgg ctagagtaga tcaggtccgc ctactccttc
    11101 gcccgctatc ggcttcagca caggatcggt cgccagacag gttgtatagc cagagaggac
    11161 attgatcatg acgctcaacg agcagcagat gaagccatct ccttcaccag gcacacatca
    11221 gccggaggat gctctttctc aggccgccct gggcaatacg ctgcggccat tcggtttgct
    11281 ggccgagttg acctatcgct gtccgctccg ttgtccttac tgctcgaatc cgactcagat
    11341 tctctcagat cagcgacagc ctgagctgac gactagcgag tggcagcgcg tgatcggcga
    11401 ggccgccacc ctcggggttc tgcatctgct cttttcaggt ggtgagccac tcctacggcg
    11461 agatttgccc gtccttgttg atagcgctcg ctccattggc ctttatacca atttgatcac
    11521 cagcgccctt ggcctgacac ggcgccgtct acaggagttg cgggaggccg gtcttgatag
    11581 cgttcagatc agcttccaag ccgacgaagc tgccctggcc gatggcattg ccggctgtcc
    11641 gggtgctcat gagcacaagc tagaggccgc gcgcctggtc aacgcctgtg gcctgcccct
    11701 gacgatcaat gtggtgcttc accgcggcaa catcgagcgc ctgccggcac tgatcaccct
    11761 ggccgagcgg ctaggcgctc agcgcctgga gctggccagc acgcagtatc tgggctgggc
    11821 cttctgcaac aaagtcgcgc tgctcccgac aaaagctcag gtgcagcagg ccgaaacgat
    11881 tgtgcgcgct gctcaggagc gcctgcgcgg acgcatggag gtcatctatg tctggcccga
    11941 ttactatgct gaacgtccca agccctgcct gtatggctgg ggccgccgtt atctgaccat
    12001 cacccccgag ggtgaggtcc tgccctgtca gaccgcccgc gtcattccca acctgcattt
    12061 tgacaatgtg cgccagcatt ccctggcctg gatctggcag cgatcagcgg cctttgagcg
    12121 tttccgcggc agccattgga tgcctgaacc ttgccggagc tgcccgctgc gtgagcagga
    12181 cttcggcggt tgccgctgcc aggccttcct gctgacaggc gatgccgcca ataccgaccc
    12241 cgcctgtagt ctctcccctc accgtgcccg tctgctcgcc atcctcagcg aggttgagca
    12301 gcagtcaggc tcctcgccca gcttccaccg ccctttcgct cccgatgggc ggcctctgat
    12361 acccatcctc ttccgcacca atcccaaatc ctgcccaggg gaataagcgg gggcacctcc
    12421 gagttttact gttatgctgt ggctggagac aaccagcatg aaagcattgc aggtagaccg
    12481 ctgtgcgatc gttcaagaga ggaggtaatc gctagcgatg gatgatgcgg aaattctgca
    12541 gcgtattgac gaactggtgg atgaggagca caaactgctc aagaaggcgg aagaagaggg
    12601 gctcacggac gaggagcgcg tgcgcatgaa agagctagag actcgccttg atcagtgttg
    12661 ggacctgctg cgccagcagc gagcgcgccg ccatgcccat ctcaaccccg atgaggctca
    12721 gcctcgcgat ccccgtatcg ttgagcatta cctgcaataa cgctcgcagc ccaagatctg
    12781 cctattccca gagaggcagc ctggctgcct ctctgtcctt tctctccata tcctctcctc
    12841 gcccaattgg tccacttcat ataatgcact tagaggctct ttctctattc cttctggtag
    12901 caaggcagaa taagatcgat gcaagtacat caacgtccta tttttcgtca gcgtgcactg
    12961 caccatcatc tctatggacg agaaaaagat attctcccgc atttcatggc attgcccgta
    13021 cccgtgctgc tctggctgct cttcgggctg cttttcgccg ccgcagcgct cgcctggaca
    13081 acggagatcc cgacctacac cgttggcccg ggcctggtac tagacgcgga agcttccagc
    13141 gagcggttcc agttgccgtc acagggggcc tttgcgctga tcttctttcc ctgggaagca
    13201 catcagaggc tgcgaccagg gcaacctgta caaattacct taccagccac caatctcacg
    13261 ctgaatagtc acatagcgcg cattttgccg ggcgtcacca gtcctgcaac cgcctgcacc
    13321 tactatacta cggctaattc gcaccaagcg tcatcaccgg tcacgcatcc ctcagtagct
    13381 gtactggtac cattaggcca gcagctctca gccagcatct atgctggaac gggcctgaca
    13441 gcgcaggtac agactggttt cacccgcctt atcaacttgc tgccaggggt tgggatgttg
    13501 tcgggaggcc agggagcgtt atgatgcacg actacggaca gcaaggacag tatggacagg
    13561 aagtaactca ggatcgcgac tatgtagaca tcttcgaccc acaagaatat atcactgcac
    13621 gtcgaccgct caagcgacgg cgtattcgtc cgatcgtcct ccagcaggag ggcgactatc
    13681 cagccattcg tcctcatctg cgcctgccag tcaggcagaa gccagcgtca gcagcaacac
    13741 cagtagtgcc cgcagccgca gccgaaggca agcagatagg cgagcaacag cagcccgccg
    13801 cagcggaggc ccaaccccct cagcaacaag gtcaggccag gccggcggtt gaggcaggca
    13861 cgccgagtaa gcgcgccagc aagcaaacct ggtctggccg aggatggcga cggcggcgcg
    13921 tccgtcccct tacccaaatg aacgtcgtcg agtgcggcta tgcctgtctg gcgatgatcc
    13981 tcaactatta cggacgccct acctcagtct ccgagctacg catgcggcat ggtctggggc
    14041 gcgacggcct ctcagcgctg agcatcgtga aagcagcccg gagctatggt ctgcgcacac
    14101 gcgccatctc attgcagcgc accgaggact tccatgccgt tccgcttccg gcagtggtcc
    14161 actgggaatt caagcacttc attgtcgttg agcgctggac tccccgctgg gtggaagtca
    14221 tcgaccccgc ctgggggcgc aagcgactca cccccgaaga attcgacgcc ggcttcaccg
    14281 gcattgtgat ccttttcgaa ccaggagtac atttcagcac cgaaggcagc gctcaccgcg
    14341 ttactctctg gatgcaggtc aagcagttcg cccgtcaaac gcgcggcacc ctgcttcagg
    14401 tgcttggagc ttcactcttc ctgcagctct ttggcctgct cctgccgctg ctcaccaaga
    14461 tcgtcatcga tcagatcctg ccagatcaca tggtcgatat catgggcatc ctgggcctcg
    14521 gcctgctgct gctcctcgcc actcaggcta cgaccacgat ccttcgcgag tggttgctgg
    14581 tctatctgcg ggcccgcgtc gacatccagc tggtgctcgg tttcttcgag catctcctca
    14641 ccctgccctt cagcttcttc caacagcgct cgagtggcga cctgcttcag cgcctgggaa
    14701 gcaacaccat catccgcgac acgctgagca accagcttat ctcaaccctg cttgacagcg
    14761 gcacggtcat cgcttatctc tttatcctgc tctggcagtc gccgatcttc gcgctcctga
    14821 cccttggcct gggactgctg caggtgctgg tccttttggg gacccatcgt attgtgctgg
    14881 acctggccag ccgcgatctg gcggcccaag gcaaagctca gggctatctg gctgagaccc
    14941 tggccggaat ggccacgctc aaggccgccg gcgccgagca gcgcgctctc gaacgatggt
    15001 cgaatctctt ctacgagcgc ctgaatatca ctctgcgcct cagctatctc caggccggca
    15061 tcaatacggc catgaccatt ctgcggatct tctcaccgat cgccctgctg tggatcggcg
    15121 cctaccaggt tctcaatggc catctcagcg ttggtaccat gcttgccctc aatacgctgg
    15181 ccagcgcttt cctgactccc gtggcttcgc tcgtcagcag cggacaacag ttccagatcc
    15241 tctacgccca cctggagcgc ctgaccgacg tcacaacagc cgagccggaa caggacatcg
    15301 agaaggctca gttgcctccg cgactcagcg gacgcatcta cgtgcagaat gtgagcttcc
    15361 aatatggacc agattcgcca cgggtgctga agcagattaa catccgtatt gagccgggtc
    15421 agaaaatcgc tattgtcggg cgcacaggct cgggcaagag cacgctgggt aagctcttgc
    15481 tggccctcta tacgccaacc gaaggcgaga tctactacga tggactgccg ctgagccagc
    15541 tcaactacca ggaggtgcgg cgtcaattcg gcgtcgttct ccaggacagc cagatcttca
    15601 gcggttccat cttgcagaat atcacgctca atgatcccaa tgttccctat gagcgtatcg
    15661 tgaaagcagc aaccgccgcg gctatccacg aggatatcat gcgtatgcca ctgggctacg
    15721 atactccagt ggccgaaggc ggtagtgccc tctcgggcgg tcaacggcag cgcctctgcc
    15781 tggcacgcgc cctggtcaat gaaccagcca tcctgctcct cgatgaggcc accagccatc
    15841 tcgatgtgct tactgaacag cgcgtctctg agaacctgcg cgcctatccc tgcacgcaga
    15901 tcatcatcgc tcaccgtctg agtactatcc gcgacgccga tctgatcctg gtcatgcacg
    15961 atggcatgat catcgagcag ggaacccacg agcagctact ccagctgaat ggctactacg
    16021 cccagcttat gcggcagcaa cttgaacagg aggaacgcca ggctcgcgct ggcgcccgtt
    16081 aaggcgcggt cccgagcctg gcccccattg gtcactgatc ctccgtgctt ttctctccac
    16141 tcgccccatt ctccctgttc caccgccttt cttccctctt ctctccttac aaatgatata
    16201 ttgaaactta tgtatttggc tttatccgta caatgtactt aggcgttcgg gtagcaaata
    16261 cgctttgaac gtattttgtt caggcaggtc agccgggcgt cgaagggcca ccttgggggc
    16321 gtcaggaagc cacctgcctg ggcagcgtta tcccaaagcg tagacggggt gcccgaacgc
    16381 acgacaccac aacaacacca aaggtacaag aaaggaaacg cacgcacatg aagttcgaca
    16441 tcgttcgcgc atggaaagat gaagcctatc gccagagcct cagcgaggag gagctcagcc
    16501 tgctgcctga gagccccatc ggtgaggtcg agctgactga tgcagatctg gaggccgtcc
    16561 agggcggtca cggcaacacc gacgagtgca ataacacggt tgccgtgctc tgtctgcagt
    16621 ccctggctgt gctcctcggc ctctgcaata ccaacgccgc tggcggctgt ctctagcagt
    16681 cgtcgcccca cgccaggggt ctcggtatgg cctgatcagg atatacagag ggttgggatg
    16741 cctgactccg tcccgaccct ctgttcgcgc cagttaaggc tgctctgaca agacactccc
    16801 agccttctgg cgctcgctca cctagccaga ccagaacagt agagcagacg agcaggcgcc
    16861 tgctgaactc ttataccagg gaatcccatc cacagccctc tgcctgccag cgcttgctcc
    16921 gagccgggtc aaacctccga gaacgatcaa tgatcgagtc cgctgcagca tggttcgcac
    16981 gttgcaattc agttgagatc cgctaccact acgctcttta ccttccagcg gtcgccagtc
    17041 ttttcgcacc gctcacctct attcttccat gttgacaagc cacctgagcg gcaggcatcg
    17101 actgctgcca caatccatcg gtaactaccg agtaatgaag aagaaagcaa agaaaggaga
    17161 tgcagcgcag taccaggctt cctggcaccg gttaaggcgg cgggatcgcc tgtcctggcg
    17221 ctgcatccca gcgcgtgatt ccatgagcga gacaacgagc gagactatca ccgcttccgt
    17281 ttcctatccg cagggtcgtt ggcaagaggc cgactggtac cgcgccttga cgttgaacga
    17341 gcgcctggcc ttgttgcgca cgaccccgtt tccgcctacg ctggatgccc tcgaggcaga
    17401 ggctctggcg cgggcccagc agcgcctgca gcgttggaaa gagctaccgg ccttgagtga
    17461 ggaagagggc cgctttgccg cccgccttgc actggatggc ctggatgagg aggagctact
    17521 gctcctgttg ggtgaacccg ccgaagtcct gcgcgcacgc tgccccgctc ctcccacctg
    17581 gctgctagct ctcagcgagg ctttctcccc tactgcaggc ccgcacgaca acggggaaga
    17641 ggccgagacc gtctgctcct ctcctctgcc aggcctggag gaagggagcc acacgcgctc
    17701 gttcctccac ccctttctgc cgttgatcag gcgcgccaga cgaaagttgg ccgccggctt
    17761 gcgggagctg gctcggcgct ccctttcttt ctcgttcgat gccgagaggg tccttgattt
    17821 actggcgcgc aatatccccg gtctattgct cccttcgatc tcgcgcgcta tcgtcctgga
    17881 gcttcacgtc gcgcgggttc agggccgcct gcacggggcc acttcggagg agcgctttca
    17941 gtatttcctg gagcagctga gcgagcgtga ggcgaccctc gattttctgc aagagtacgt
    18001 ggttctggcc cgtctggtaa cggagacgct tgagcgctgg gtctgccgct cactggagct
    18061 gctggagcgc ctcaccgacg actggccact gatctgctcc actttcctca ccaacggcga
    18121 ggccgggtcg ctgtgcgaga ttcaccaggg cgccggggac ctgcatcgca acgggcagag
    18181 tgtgatcttg ctacgctggg actccggttt ccgcctggtt tataaaccgc gctcgctggc
    18241 tattgatcgc cattttcagg agctgctcgc ctggatgaat gaacgaggct tcagcccacc
    18301 tctgcgtacg ctgacagtcc ttgatcgggg acactatggc tgggtcgagt ttgttcaggc
    18361 tcgccactgc tcctctcgcg aggagattga gcgcttctat ctgcgccagg gcgcctacct
    18421 ggccttgctc tacgccctgg aggcctcgga ctttcatgcc gagaatatca tcgcctccgg
    18481 cgagtatccg atgctgatcg atctggagac gctcttctta ccccagatca accccgaagt
    18541 gttgcaggcc cagggagcgc ccggcctgga ggccatcggc cattcggtgc tgcgcgtggg
    18601 cttgttgccg cagcgcctct ggtcaaacca ggagggtgag gggatcgata tgagtggcct
    18661 cggcggccag cccggccagc tctctccgcg ccctgtccct acctggaaag gtacaggcac
    18721 cgatgagatg cgcctgacca atgagcgcgt cgagctgccc gtgaaggaga atcgcccgcg
    18781 cctcaatgac caggatatca atgttctgga ttacagccag tgcatcattg agggctttac
    18841 tcgcgcctac cgcctcctca tggcccaacg ctcggagctg ctcgagacct atcttccacg
    18901 ctttgccgat gctgaggttc gctgcgtgct ccgtccaaca cggatttata cgcagctgct
    18961 ggtcgatagt ctgcatccca acgtgctgcg cgatgccttg gatcgcgatc gtctctttga
    19021 ccgactgtgg gctacgacgg agcgcctccc gtatctggtg ccactgatcc ctgctgagcg
    19081 gcgcgacttg tggcgcgggg atgttccggt ttttacgacc acagcagcgt caactgatct
    19141 cttcacgtca gagggcgagc gcctgtctgc tttcttcagc gaacccggcc tggaagtggt
    19201 acgccgacgc ctggccgagc tcagtgagct ggacctggag aagcagctgt ggatcattcg
    19261 tgcctccttc acgagcatga tcgatgccac cactccccag agctacacac gcctggagct
    19321 gcaccccgcc cgcacttctc caaccctgga gcggctgctg gccgccgcct cggcgatcgg
    19381 taaccgcctg cgccagtttg ctctctacca gggtgagtat gtgggctggc tgggcgtgac
    19441 accggtgaac gaccgcgagt ggcacttgct acccgccgat ggcgatctct acaatggact
    19501 ggcaggcatc gcactctttc tggcctacct gggccacctg acaggcgagc agcgccacac
    19561 tgagctggca cggatggccc tgcgcacgat ccagcagcag attatgcgcc gcaagtactt
    19621 cccccgcgct tacggaatcg gcgccttcaa tggcctcggc tctttgatct acctcttctg
    19681 ccacctgggc gccctctgga gcgagcctgc cctctatcgt caagcagagg agctggttcc
    19741 ctcgctcctg gcgaaggttg agcaggacca ggtctatgat gtgatcggcg gagccgcggg
    19801 agctatcgca gcgctgctct gcctgcagcg tgtgtctccc tcgcccgaaa cgctggcggc
    19861 tgctgtccgc tgcggcgagc atctgctctc ccatgctcaa ccccaggcac agggcggctg
    19921 cggttggcca acgacgcgtc agccggtcgc gctggccggt tttgctcacg ggaacgccgg
    19981 gatcgccttg tacctgatgc agctggctca ggtcagcggg gagacacgct ttgccgagat
    20041 ggcccgtgca gcgctagcct atgagcgcac gcttttctcg ccctcacgcc agaactggct
    20101 ggatctgcgt cagcgcccac cttcttcagg tgtcaaccag ccagtagggg agaaatatat
    20161 ggtggcctgg tgccatggcg cacccggggt ggctctctcg cgcctggccc tgctctcgct
    20221 gctcgatgac caggagctga cagaggagat caaagccggt ttgcgtacga ccctgactca
    20281 gggttttggc ctgaaccatt ccctctgtca tggggacctg ggcaacctgg atatcttgat
    20341 caccgccgct cgcctgctac ccggcgagac cttcgctgaa catatcccac gcatcgccgc
    20401 ggccttgctg gagaatatgg agcaccaggg ctgggtctgt ggtgtaccgt tcggggtgga
    20461 aacacccgga ctgatgacag gactggcggg gaccggcttt gcccttctgc gcctggcctc
    20521 tcccgagcgc gtcccctcag tgctgctgct ggcaccgcca atggcgccct caacgcccgc
    20581 agtctgagtg gagcatgctg aacatagacc ccccccaacc gatggtacgg cgttggagac
    20641 aggtccatag gagcgggaaa gaggcccggc tcagttcgag accaagggga gcagtcgtcg
    20701 cgactgctcc ccccaatgca cagaatacgt agtgaagcac ctttgcttcg taaggaatca
    20761 cgcaccaggc tcatcgcttt cccctcccct agtatagagc gacacaccaa gagtggccct
    20821 cgcctgtctt tcttcactcg ctctctccac tgtctccacc ggcaaaccaa cttgctcgac
    20881 tggaccttga cagcgagcct cttgctatgg ggtctgatcg ccttcctgct taccctctac
    20941 tggatcaccc gcgtcgaacg cgacagcggt cgcttgcgcc cgcgctggag cgaaatcttc
    21001 acgcgcttcc ccaagtttgt catcggtttc attccggcct cactcgtcat ggccgtcctg
    21061 atcaatttac atctgttgca gtccagtccg gcgatgatca acgacctcaa cgcgctgcgc
    21121 accttggctc tttatcctgg ccgtcgtgag catcggtctg ggcttccggc tagagagctt
    21181 caaattggct cttcgccttc cacagtcagt cagcttgcag aacaagggca gcgagcatgt
    21241 ggccagtctt ccccctacgt ccgttgccct ctcttagccc cgcgcgatcc tggcagcgtg
    21301 agtaatgatg gcagggggta ggacggtagg atgggacggg ccgggaaagc aaactgctga
    21361 ggagagcaaa agcagagggc ggaatgaccc tcctggagga gattgtcact ccgccctctt
    21421 cctctatggt atggaggtgc cggtggtgag actcgaactc acaacccttg cgggacctgt
    21481 ttttgagaca ggcgcgtata ccgttccgcc acaccggctc tggagccagg agcactttgc
    21541 caagcagctg ctcagactca gaaaagctgc caggctgaca gcgagcatac ctgtccttcg
    21601 ctctggcagc ttccagtata caaaagtctg cgactgacgt caagccccgg ctgagcaagc
    21661 agaaaaccgt gcgctccgga cttctcttat actcacgagg caaaaccaaa cggtccgacc
    21721 gcgcgatact tctcgtagcg catctgcacc agtcgatcga caggaatctg cctcagctcc
    21781 tgtaaatggt gaatgagggc catcttaaga ttctccgccg ccagccgatg gttatggtga
    21841 gcaccgccca ggggctcagg gaccagctca tcgatcagcc ccaaagcgta tagctcgcgc
    21901 gcgctgatgc gcatggcctc tgccgtctgg ggggcataga ccttatcgcg ccagataatc
    21961 gaggcggcgg cctcgggagc ggccaccgta taaatactat attccagcat cagcaggcgg
    22021 tcagccacgc tgatggccag agcgccgccg cttcctccct caccgatcac cgctgcaatg
    22081 ataggcacgc gcaggcgagc catcgcatag aggctggccg caatagcgct gccctgaccc
    22141 cgctcctcat cctccaggcc aaggaaggcc ccctgagtat cgaccaggca gatgaccgga
    22201 tagccgaatt tctcggcctg ctccatgagg cgaatggcct tatggtagcc ctccgggtga
    22261 ggcatgccgt tgttatgata catcttctcg cgcatgccgc gccccttctc gtggccgatg
    22321 atcatcactg tttccccgtt gaagagggca gggccgccga tgatggcctg atcatcaccc
    22381 acgcggcgat cgccatgcag ctcgaagaac tcctcgcaca tcagatggat gaaatcagcg
    22441 gtataggggc gatccttgtg acgcgccacc tgaaccgtct gccaggcagt cagactgcga
    22501 tagatttcct ccgtacggcg gcgcagctcg cgctcgtact cctgcaactg gacatgctcc
    22561 tccgggcgga ggcgctcccc cttacgctgc agggaggcaa tgcgcttctc tagctccgcc
    22621 aggggcttct caaactcaag atcgtagacc atcctgacct cctccaacct cggcccgcga
    22681 ctgcgctggc tggcgagaca agagtgttgc cgcctcgacc gacgactgcg cagcgggggc
    22741 agattgctgt gcccgctcag cctccggaac cttatagagg cgcagcaggc gggccagcgt
    22801 ggcgcgcaac tcgcgccgat ggaccacagc atcgatcatc ccatgctgga gcacaaattc
    22861 ggaattgact gttccctcgg gcaacttcac atgcataaat tgctcgatga cacgcggacc
    22921 ggcaaaggca atcaaggccc ccggctcggc caggatcaca tcaccaagca tggcaaagct
    22981 ggcggtgaca ccccccgtag tcggatcggt aatcaagctg aaatagggaa tgcgggcctc
    23041 actcaggcgc gccagagcgg cgaccgtctt ggccatctgc agcagtgaat agaaaccctc
    23101 ctgcatgcgc gctccaccag aggtcgagac caccagcacc ggccagcgac gctccaaccc
    23161 cagctcgatg gcgcgcgtca ccttttcacc caccaccgag cccatgctcc cgccgataaa
    23221 gcggaaatcc atcaccgcta gcgagagcgg tagcccctcg atcgtaccgt agccacggat
    23281 cgctgcctca ttgaggccca ccttggcccg ctcttcttgc agcttcgccg cataggactg
    23341 ggagcggctc acgaagttca gaggatcaac cgagaccatc gcggcgtcca gctccacaaa
    23401 actgccggga tcaagcagga ggctgacccg ctcatgggcg gtcaagcgga agtgatagtt
    23461 gcagcgtgaa cagaccttta aattcttctc ccagtctcgg ctatagagga tctccttaca
    23521 tttggggcat ttaaccatca aattatcggg agcaaccccc ggtcccgaag gccgctcagg
    23581 ttgcggccca ccagaagagc ccgccgcttc cttcgccata acagtaccct cttatgtttg
    23641 tgacgttgcg atgagtcgtt gatgttgccc ttatctgtag cagcagcagt tgtttgactt
    23701 cactattcat cctgggccag aagtgcttct acaaagctct ctggatcaaa gggcgtcaaa
    23761 tcggtgacct tctcgccggt accgaggaac ttgataggca cgcccaggtc gtcggccaca
    23821 gcaaaggcaa agccaccctt ggccgtacta tccatcttgg taatgatgac gccagtcaga
    23881 ccaacatctt cagcgaactt tcgcgcctgc aacagcgcat tctggcccgt ggtggcatcg
    23941 atcacaatga gcagctcctg ggggccctcg ggcaggaact tctgtaccac cttcccgatc
    24001 ttcttcagct cctccatcag gttgaacttt gtgtgtaagc gtccagcagt atcaaccagc
    24061 aagacatcat ggccacgaga gaggccagcc tgaatggcat catagaccac cgccccggga
    24121 tcggagccgg ggttctggct gatgactggc acatcgatgc gctcccccca ggcttttagc
    24181 tgttcgatcg ctccagcacg gaaggtatcg gcagccgcca ggatgacgcg atggccctcc
    24241 tgcttgagac ggtaggcgag cttagccacc gtagtggtct tacctgagcc attgacaccg
    24301 atgatgagca tgaccgtcag cggcgcctga gtggcaaagt gcaatggtgc cgctttgccg
    24361 agcagggtca gcagttcttc acgcagagca cgccgcacct gcgaggttgt acgcaagcgc
    24421 tcctgctcag cccgctcgcg caggcgctca agcagccagg tcgttgtgct agccccaaca
    24481 tcggcttcga tgagggactc ctcaagctca tcccagaagg tgtcagttac cggctcgtct
    24541 tgccggaaac tctcctgcac ccgcccaaag agccggcgcg tacgactcag gctggccttg
    24601 agaaagctca gccgctgctc gaacgccgag tccgccccct tccgctcctg ccctgcaacg
    24661 ctctcttctt gcctggcagc ttcttcttcc tctttcggtt tacgaccaaa aaatctatta
    24721 agcaccgtga tttcgactcc ttcaggcgat cagagacttc agcccaatcg ttcgccaaca
    24781 gcgcactgtg ctctccttcc gcctgcccct cgcctggttg ctcccagatc taccagcgtg
    24841 atcactctgc ccccatctgg gaagagcaga ggaggcaagc gctggccgcc cgcgatccgg
    24901 tccccaggca gacaacaaga aggagccagg ccagcagact gacagacctc actcgcttcc
    24961 tgccggcccc agccatcagc tttcattgta gacgattcct acctgagaag taaagggagg
    25021 tctggctcac gcgcgctcac cggatagcga gaaaggcaac aagccattga agagagtcac
    25081 aggcagggat agtagccacg ctcgcacttg ccttgctatg cgccgtctca acagacaaac
    25141 ctcgctacag ccgcaagcag gccttacgtg gcacggaaga gagccaagag ctgggggatt
    25201 agccgggcag aaagcggcgg aagaagagag caaatggggc gaacttgtaa gtgagggcct
    25261 gctcacctgg gacggagccg tgcggcaggt gagaacgccc tcgctttaca agtgcgcgct
    25321 gaagctgaaa aggcatcagg cagagcaaga gcatcgtgcc agcgtctttt cagcagctaa
    25381 acacacaaag gaacccgttg cacgcgaccg aaccggatcg ggggcagggc agcggcgggt
    25441 atccctgttg cccaccaccg tagccatcca ggtactgcgc tgattgctct atggatggga
    25501 tcttagcaat tggaggccgg ttcacgagcg gctgccacgg tactgatgga gagagccatc
    25561 actaatgggt tcattaatga tgatatctcc attcctgatc ttgatgttgt acaggcaaga
    25621 gggattggta cagacccagg ccttgtactc gatagaagct ccctggctgc cgaagtccga
    25681 aagcggaacc agatcacctt cactacattt gcgacaccga ggaaacgaga attccacgaa
    25741 atcgcctcct tccttctctc tggaggattg tattcgcctg cctaaccacg agaccaggcg
    25801 aggctgggcg aagaagtaag ccgaggggga gcctccgcct ctgcatccgc gtccccacag
    25861 cagtcataca tagtccatgc cgccgctatc ataccacaga ttgtctcttg tgtgacaccc
    25921 tctttcccta tgaggggtcg gttttgctgg gaacggccaa tcccaaccgc tcgcgcgtgt
    25981 atctcttcga taccacacga ttataacata tctattcgtc acacacaatt gtttctgccg
    26041 aaatggcaag caagaagcaa gcgcggctga gggtcgtcag catcgtttga ggtcaggatg
    26101 ggggctgacg tgaacatacc tgagcttgcc ctcaccagca tcctcctctt gcgcttcgcc
    26161 tcctgcccca ctccgccgcc tgtttgctca ctctacacat tagcatacca gggagaagca
    26221 agtcctgacc cggtccaggg agacactgtc tgcacctgtc ccttgcagct ttggcagcct
    26281 ggtggctttc cgccagtttc cgcgagcgag cgagcgagtg ccagcgaaga gcggtctgct
    26341 gcctggctgg ccagccaggc cagccgggtg aggaaaattc cccagaggtg gaaatctctt
    26401 cgccctccag tagattcctg gagggaagac cagcgtcttt cggctctcca ggcgctctgc
    26461 tctctgatct ctccgcccgg agacaaggcc aggcttgcct cttgccatca ggctcatgat
    26521 ctcctcacct ttttttgcga cctgctctta ccctttggca tgctttttgc gaatccagag
    26581 aagtgtggga gcgcaaaccc tgcgccgccc ctggtccttc agtcagggcg gccctttcaa
    26641 tccactggca tcggttgcat gagcagcgtg atcaacgcga cctcatctgc gccataagga
    26701 gcttgagtaa tgggagtgcg aggaaacaag gcagagacgc atcttggtct gcttgaggtg
    26761 gatgatatga cttctgcggc ccagcgtcca aagaagagag cgggacaacc caggcacccc
    26821 ggcaaacgca gccgtcaggc agccgccgct ttcgatgagc ctagcccctc cgatctcgac
    26881 ctggaaagcg aagaggctgt tctcgctgag ctgggagaag aggaggacga ggatgaggat
    26941 ggaggggaga catcagaacg cagtgccatc gatgacactg tgaagctcta cttgaaagaa
    27001 atcggctcct atccgctgct gactgcagag caggagttaa tgctcgccga gcgcgtggcc
    27061 caaggcgacc ttcgggcccg tcagcgcctc atcgagtcaa atctccgtct agttgttagc
    27121 atcgccaagc gctacaccaa ccagggccta cctctcctcg acatgattca ggaggggaac
    27181 atcggcctca tgcgagcggc ccagaaattc gactatcgcc gcgggttccg cttcagcaca
    27241 tatgccacct ggtggattcg tcaggccatc agccgggcga tcgcggagca ttcgcgcacg
    27301 atccatatcc cggtgcacgt tgtagaactc atttaccgca ttaagcgcgt ggcccgacgc
    27361 atctatcagg agcaaggcgt tgagccgctg cccgaggagc tagctgccga ggtaggcctc
    27421 cccaaggagc gcattgtcga gcttctcaat atctcggagc agccagtctc tctcgatgct
    27481 ccggttgccg atgacgaaca gtatcacctg gccgacacgc tggaggaccc cagcatgatg
    27541 gccccagagg acagcgaagc acgtcagcga ctccatgacc atcttcagca ggcaatggag
    27601 attctcaatc cccgcgagcg gacgattctt gagatgcgct acggcctgca ggatggttgt
    27661 tctcactcat tggacgaggt gagcgcccgc ttcaaactga cacgcgagcg cattcgccag
    27721 atcgaggtga aggcactacg caagctgcgc tatcccgagc gctactacgg tctgcgcgaa
    27781 tttgcttcgc tctgaaaggt aaggtaagga ggaaggagat cggcgagccg accagcggcg
    27841 gtagagagag cgcaccaccg ctggtctggc tccgcctggc tcttcttcca cctcttcgct
    27901 tcgaggatag aggaacctgc caggcgtcag gctagcgttg ggcgctcacc gcctggtgcg
    27961 cctgcatctg gaggtacgcg cgaataaagg gatcaagatc gccggccagg tacccctggg
    28021 tatcgctggt ctcatagccg gtgcgatgat ccttgacaat cgtatacgga tgcaaagtga
    28081 ctgtgcgaat ctgggtccca aagtcggcct ggacatattc gcccttgaga cgcgcgactt
    28141 cctcctcacg cttgcggcgc tccaactcgt agagacgcgc ccgcaggatg cgcatcgcca
    28201 cctcgcggtt ctggatctgc gaccgctcgt tttgacaggt gactacgatc cccgttggaa
    28261 tatggcggat gcgcaccgcc gaatcggtct tgttgacgtg ttggccgccg gcgccggtcg
    28321 agcgataggt atcgatatcg aggtcttcgg ggcgaatggt tacctcgatg gtgtcctcaa
    28381 tatcggggat gacctcgacg cgggcaaagg aggtatggcg gcgatgcgcg gcatcgaagg
    28441 gcgagaggcg aatgagacga tgggttccaa tctcggaacg caggtggcca taggcatagc
    28501 gtcccgagat ctcaaccgtg gcgctcttga tccctgcctc ctcaccttca ttgtaatcgt
    28561 agatctgggt gcggaagcga tgtcgctcgg cccagcgcaa gtacatgcgc agcagcatct
    28621 cggcccaatc ctgagcatca acgccgccgc tgcccgcatg gatgctgaga atagcgtcgc
    28681 gttcatcgtg ctcaccgctg aagagcagag ccagctcaag ctgctctacc tcctgctcta
    28741 cagcattcag cgagcgcgtg acctcagcct ccagatcagc atccggttcc tctcctagca
    28801 attgcgctaa ctcctgcaga tcttgaagct gcttctccag tctctcccag gtctcgactt
    28861 cttcgcgcaa tgctgtgagg tgctgcatat gagactgggc ccggcgattg tcggaccaaa
    28921 aatcgggttg gagcgtctcc gcctcgagag ccgcaatctg ttctcgtttg tgcgccaggt
    28981 caaaggcgca ccatcgtttc gtggactcgc cattgcaggc gttcaatacg cgaggtcagc
    29041 tcactcatgg ttgttattgt agcatgtttg tagctccgac gaaagagctg ttccgttcag
    29101 cagactggcc cgagctgctc tctcaccccc gcagaggcca aaggcttatt ggaggagttt
    29161 cgccatatag tattcatcga cagactgccc atcgacgacg agggcttgac ggcgcagacc
    29221 ctcgaccata aagccctgcc ggagatagag ggccagtgcg cgctggttat ggaccatcac
    29281 ggttaattcc agacgatgaa aactccgttg ccgggcccag ctctccatca cctggaagag
    29341 acggctgcca attccctggc ctgtaaaggc ctggaggatg ccgatgacca gtgtagcccg
    29401 ctgacgttcg cgccgatagg ttcctccttc aagggccagg tagccaacca gctcgccact
    29461 ctgcccggcc tcggccacaa aaatggtcga gcgccccgta gccagcaggt tttcaagcgc
    29521 ttgccgctgc tcgtccggcg tcagggtgcg ctcgtcaggc tccagtagca taaagcgtgt
    29581 ctcctggtcg agtcgcttac aaagcgtcag aaaggcctca gcatcgtctg gtgtaatctc
    29641 tcgaatatga acaacagtgc tcatcacgat gcgcttgttt ccttctcgct attgacgatg
    29701 ctctcacttc tcgtggctac cagccctgct ctggttgatc cgtcgatcac tcacaagcat
    29761 cctactgctt ttgttcctgc aagcggagag cgagggcacg ctgtagctgc tccaaggaga
    29821 cgttgccgcc cgagcagacg agagcgactt ttttgccttg cagctcgtct cgcagccgat
    29881 aggctgccgc cagggccgcg gcgcctgctc cctcggccag cgtatgggcc agttcagcca
    29941 tccaggcaat cgcacgcagg atttcctcgt cggagaccaa tacgaattcg cgcagcttct
    30001 cctgcaggat ctgttgcggt aaggcaaaag agaccccggt tgccagtcct tcagccaggg
    30061 tgcgattcgg agcggtcacc agccgccgct ggcgccagga ttcgtaagcc gccggggctg
    30121 cctcggattg cacgccgatg acgcgcaggc caggattgag cgtacgggcc acaagacagg
    30181 cgccggcggc cccactgcca cccccgatgg ggacaatgag tacctccagg tccgggcagt
    30241 cctccagaat ctccagggtc agggtcgcca caccggcaat tagcagtggc tcatcccccg
    30301 aatggatgta gcgatagcca tgctgccggg ccagctcttc acagtaggac ttggcttcat
    30361 cataggtcgg accatgaaag atgacttctg cacccatccc gcgcatggcc gctactttgc
    30421 ccggattcgc tccttcagga acaacgatgc gcgctttgac cccaaagagg cgggcagcat
    30481 aggccaccga ttggccgtgg ttgccggtgg aggccgcgat aaccccccga gcgcgctcct
    30541 cgggcgtgag acgcgcaatt agattgacgc ctccgcgtac tttgaag
//
