LOCUS       NZ_MCIF01000002        32607 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Thermogemmatispora tikiterensis strain T81 A4R35_scaffold00002,
            whole genome shotgun sequence.
ACCESSION   NZ_MCIF01000002
VERSION     NZ_MCIF01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Thermogemmatispora tikiterensis
  ORGANISM  Thermogemmatispora tikiterensis
            Bacteria; Bacillati; Chloroflexota; Ktedonobacteria;
            Thermogemmatisporales; Thermogemmatisporaceae; Thermogemmatispora.
REFERENCE   1  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Analysis of Carbohydrate Active Enzymes in Thermogemmatispora T81
            Reveals Carbohydrate Degradation Ability
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-AUG-2016) Faculty of Agricultural and Food Sciences,
            University of Manitoba, 66 Chancellor's Circle, Winnipeg, Manitoba
            R3T 5V6, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2011
            Assembly Method                   :: Newbler v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 25.9x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003268475.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 03:19:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,660
            CDSs (total)                      :: 4,607
            Genes (coding)                    :: 4,541
            CDSs (with protein)               :: 4,541
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 8 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 6 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:11:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 396878
            Orig. end                         :: 429485
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MCIF01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..32607
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="3"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..32607
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..32607
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:22607](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..22607
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    1282..1295
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: strong, score: 23.52"
                     /tool="antismash"
     gene            complement(2998..4299)
                     /locus_tag="A4R35_RS01815"
                     /old_locus_tag="A4R35_01765"
     CDS             complement(2998..4299)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS01815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_01765"
                     /product="hypothetical protein"
                     /protein_id="WP_112425972.1"
                     /transl_table=11
                     /translation="MPVTQTSCPGISPTNPFGTRPAVMRPLALGSHQNLVYIYNEGQSQ
                     TSTAHGHLVRYDVATGQRVTIITSGLHISEAQVSADGQWIMFLSLPDPQRDPNHVALLQ
                     MVRMDGQGLQTLYCFPKLPYTPKGGAFSAFEGRGIISYTGYPPVRFTWSPDERHVLLST
                     DLQGTTSLVTLLDIRTGNLRQLLLYTQSCSIAIPLSWLNSSQAYIVTESRATCGSPPLP
                     MNLYLIDVNKSPNPANPVWNDVIEENVRYTDVAVDTSPDGSRLFVSTCEQTGPAISTIV
                     SEPAAGGSQTTIYRQLASAQNPESCVESIRAVTTRTLLMLMRNGSPYLQCGAPYQATFQ
                     LAMLSSDGRGRPRVLANLEQGSSYSLDQAVPALWSLISRDGHLYAMTGAKPLACGNALI
                     EETTVFYGSLSGGEPVAVATASNGTVDVVGWTAL"
     repeat_region   5046..5968
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=402073..402109
                     /rpt_unit_seq="gtttcaatcccagacgggcaggatcgctgattcagac"
     misc_feature    5762..5771
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.89"
                     /tool="antismash"
     misc_feature    complement(6708..6717)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 17.48"
                     /tool="antismash"
     gene            6864..7808
                     /locus_tag="A4R35_RS01820"
                     /old_locus_tag="A4R35_01770"
     CDS             6864..7808
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025217.5"
                     /locus_tag="A4R35_RS01820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01770"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_112425974.1"
                     /transl_table=11
                     /translation="MPWWFFRRKRPTVPQSSLPPVSDASETAQFSSWANVTTLADRTDT
                     DQRRYLEEQPYLLPKDLQEVNRLDFQHYVLRAALRRNYLAPIQAPRQILDVGCGTGQWA
                     SELAREFPQASVVGLDVEEAKQQTAPPPNYRFVKGDVLNGLPFPDHSFDFVHQRFLWTA
                     LPLAAWPRVVQELARVTAPGGWVELLEPGLEAAPMGPTHRRLDAMIKELAALRGLDGEG
                     AVTASLDRYLWEAGLSQVQRQVIEVPFGDWGGRIGSLLALDFREFALALSGAATKRFQL
                     SHQQYQALVQTMLQECNELKTMYHFVAAYGRKL"
     gene            8980..9189
                     /locus_tag="A4R35_RS01830"
                     /old_locus_tag="A4R35_01780"
     CDS             8980..9189
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033399.2"
                     /locus_tag="A4R35_RS01830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01780"
                     /product="thiomuracin/GE37468 family thiazolyl RiPP
                     peptide"
                     /protein_id="WP_223258146.1"
                     /transl_table=11
                     /translation="MNELHGELAQLELEGLSLDNLEIEDLKLSSEGGLELLTTGHGMVE
                     IGASSGQTACCSCCIVCCCCPCLG"
     gene            9334..9534
                     /locus_tag="A4R35_RS01835"
                     /old_locus_tag="A4R35_01785"
     CDS             9334..9534
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033399.2"
                     /locus_tag="A4R35_RS01835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01785"
                     /product="thiomuracin/GE37468 family thiazolyl RiPP
                     peptide"
                     /protein_id="WP_223258147.1"
                     /transl_table=11
                     /translation="MQDLHGELAQLELEGLSLDSLEIEDLKLSNEGGLELLTTGHGMVE
                     IGASSGQTACCSCCIVCCCCW"
     CDS_motif       9334..9489
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence:
                     MQDLHGELAQLELEGLSLDSLEIEDLKLSNEGGLELLTTGHGMVEIGASSGQ"
                     /locus_tag="A4R35_RS01835_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       9490..9531
                     /prepeptide="core"
                     /locus_tag="A4R35_RS01835_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type III"
                     /score="7.90"
                     /molecular_weight="1314.7"
                     /monoisotopic_mass="1313.4"
                     /core_sequence="TACCSCCIVCCCC"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MQDLHGELAQLELEGLSLDSLEIEDLKLSNEGGLELLTTGH
                     GMVEIGASSGQ"
                     /leader_location="[9333:9489](+)"
                     /tail_sequence="W"
                     /tail_location="[9531:9534](+)"
                     /alternative_weights="1332.7"
                     /alternative_weights="1350.7"
     CDS_motif       9532..9534
                     /locus_tag="A4R35_RS01835_thiopeptide"
                     /note="tail peptide"
                     /note="thiopeptide"
                     /prepeptide="tail"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     gene            9627..9824
                     /locus_tag="A4R35_RS01840"
                     /old_locus_tag="A4R35_01790"
     CDS             9627..9824
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033399.2"
                     /locus_tag="A4R35_RS01840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01790"
                     /product="thiomuracin/GE37468 family thiazolyl RiPP
                     peptide"
                     /protein_id="WP_112425978.1"
                     /transl_table=11
                     /translation="MEDLKQELAHLTLDELQLDELNIQPLTADRDGLEALTLGHGMIEI
                     GASVLPEGCCSCCIPCCCCW"
     aSDomain        10001..10243
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R35_RS23820_Thiopeptide_F_RRE.1"
                     /evalue="2.00E-26"
                     /identifier="RREFam004.1"
                     /label="A4R35_RS23820"
                     /locus_tag="A4R35_RS23820"
                     /protein_end="81"
                     /protein_start="0"
                     /score="82.7"
                     /tool="antismash"
                     /translation="MRPRMRGDVFYFPTPEGVYLRNNQGAFHLRGKGLARLLDLLLPYL
                     DGQHTLDEITQQAPGEQRALISKLIEMLTARGFIRD"
     gene            10001..12196
                     /locus_tag="A4R35_RS23820"
                     /old_locus_tag="A4R35_01795"
     CDS             10001..12196
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.5"
                     /locus_tag="A4R35_RS23820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01795"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_146747085.1"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 3.4e-24,
                     bitscore: 82.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     6.1e-19, bitscore: 65.8, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 1.4e-07, bitscore:
                     29.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 3.8e-07, bitscore: 28.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPRMRGDVFYFPTPEGVYLRNNQGAFHLRGKGLARLLDLLLPYL
                     DGQHTLDEITQQAPGEQRALISKLIEMLTARGFIRDLTPDHPHQLSAAEQETYAAEIAF
                     IEAFQDSSAWRFERYRQSRVLLIGSGLTLQALVQAALHSGLADISVLITGECPLDRQRL
                     QEYLALRQTRDPLQQLHILEPLNWDDEQTVARTLAPFEAVLHLSDRPMLRRSALLNRLC
                     YQQGKLFLSATILDTQAWLGPLVLPAPAPGGHEASRGCWECAWLRLLANLPPEMATTLD
                     DFADHPETPLSYALAVPTAAVVANTLNFELFKYITEAGPLETSGHLLFIDLETLQSQRH
                     PFNASAHCRCCRQAGPLTASYFRDLVRERSTGPVLSQEDFSRKAARLFDARLGLFSALD
                     EHNYTQIPLNIARVDLAQPAPRLSRGETWRVFGAGSDFGAARRAATLRACECYAAWCYD
                     PRRSLSGSAPELVGTAPEAFTCYTRSLEPSTSLDPQEDYLWAWELPGEQVALVPAATVF
                     PLSTEEERLQLPPVGVAAGMSWSEALCRALFTYGCAALEQRLAQSREPFPQVEIEALTL
                     SEAAQRYRHLLALQEIAIAVYDLSALLSDWGLLAFAFCCNEETWTYTCHVQVQAAIEEG
                     LRLCLQHAQALRNSESDYALLPVTPLPSALRGETLIAPPYPPVEAWEQMLPALLAALQS
                     QGRRALIVPLDHDAALTEALPYIVRIVLGKRRVDDGR"
     aSDomain        10010..10273
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R35_RS23820_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="3.70E-21"
                     /identifier="RREFam011.1"
                     /label="A4R35_RS23820"
                     /locus_tag="A4R35_RS23820"
                     /protein_end="91"
                     /protein_start="3"
                     /score="65.8"
                     /tool="antismash"
                     /translation="RMRGDVFYFPTPEGVYLRNNQGAFHLRGKGLARLLDLLLPYLDGQ
                     HTLDEITQQAPGEQRALISKLIEMLTARGFIRDLTPDHPHQLS"
     aSDomain        10043..10264
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R35_RS23820_NHLP_CD_RRE.1"
                     /evalue="8.80E-10"
                     /identifier="RREFam015.1"
                     /label="A4R35_RS23820"
                     /locus_tag="A4R35_RS23820"
                     /protein_end="88"
                     /protein_start="14"
                     /score="29.5"
                     /tool="antismash"
                     /translation="PEGVYLRNNQGAFHLRGKGLARLLDLLLPYLDGQHTLDEITQQAP
                     GEQRALISKLIEMLTARGFIRDLTPDHPH"
     gene            12186..14225
                     /locus_tag="A4R35_RS01860"
                     /old_locus_tag="A4R35_01800"
     CDS             12186..14225
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="A4R35_RS01860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01800"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_189361227.1"
                     /sec_met_domain="YcaO (E-value: 7.1e-78, bitscore: 260.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 9.9e-109, bitscore:
                     361.7, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAADLKNAQSRPLLGLLAEGHRLGQAVREVLREWGEPVEVTQADL
                     RAAQVPACTLLLVICEGWHGPLLREANRWSLASGRPWLGLSIEPGRAVLGPCVLPGHSA
                     CFTCAELRRVNAHKRAEEFQAERAYLEQQACSELQPDAVSAPTRTWLTAFAQAILAQQV
                     AREVAQFLQAPEAMLTCNALLYLDLATLRISRHPFLPEPHCPDCSALPADSAAAAQAAM
                     TLVARQKLAPQTYRVRDLLSLKDRLLARYVDPECGLICGLTKDSSNLYANFAAHIHFQQ
                     GRRQEVGFGRAFNYEQGQVAAIAEALERYAGMRPGGKRTAVRACRRELGEAAIDPRTLG
                     LHSEAQYSLPHFPYVRYSDDLVLNWVWGYSFARQQPVLVPECNVYYGLHYWTHERPYVY
                     EISNGCAIGNCLEEALLHGILEIAERDAFLLTWYARLPMPRIELQSARDPLVGLMCERL
                     YHLTGYSVHAFNITLPERIPCFWVMAVDEQQRPDYPRALCAAGSHLLPEKALINALQEL
                     APIVGSHISLYRQEREHARGMLADSSRVTQMRDHALLYCLPEAFERLAFLYETPHQQTF
                     AEAFDGDEPPTHADLREDVLEVMGRYLRSGIDVIAVDQTTPELAREGFWAVRVLMPGML
                     PMTFGHHARRCYGFKRLYELPYRLGYAARPLTDADLNPYPHPFP"
     gene            14249..15874
                     /locus_tag="A4R35_RS01865"
                     /old_locus_tag="A4R35_01805"
     CDS             14249..15874
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03605.1"
                     /locus_tag="A4R35_RS01865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01805"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_112425986.1"
                     /sec_met_domain="PF00881 (E-value: 0.00012, bitscore: 20.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQDREIGLRYLQATYYGLPELFAEGQGEEGMPGEPLKFKIYRG
                     VPHYPLNQRLPLSLGDLRRALASQGQDTHCGAGPRSLDDQTLSCLLYYSYGFSRHDSGL
                     DARWPFHRLVASARCFFPAELYAWLPASAPIPPGFYHYDNLHHSLAALRQGDYCAVLSA
                     ALGCELTDSLGVLFVSAYFWKNAFRYRNFSYRLCSQEVGMVVGNILLVCGVLGIAARVH
                     YQFLDRVLIRLLGLEDGEESPFAAVVLSPAESEREATKTLPAPAVSAEALLREIAPIAP
                     AHVKLSALDRERCQKLLEIDQHSRLESGAELAVSLPPATSSCDQALPTLEAPAPWPEEL
                     ELVQALYQRSSGDVFFLPLYRSVSRAAFWEIVRYSLAPYASDLGGVDRRRPALELFLAL
                     NNVADVPAGIYRLCGSCGALHVVEQRAVAAQIQAIHSTPAVNCGSAPFVAYPVASYGAL
                     SAALGNRAYRIMNMECGLVAQRLSVLSAAFGLVARCSDSYHLDRCAELLHLRERVETPL
                     FLIAFGYERPGAGAGARYRHSIRL"
     gene            15889..18681
                     /locus_tag="A4R35_RS01870"
                     /old_locus_tag="A4R35_01810"
     CDS             15889..18681
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="A4R35_RS01870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01810"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_112425988.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.7e-64, bitscore:
                     215.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.9e-06,
                     bitscore: 26.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEQHTCSVAAEYVVRVAGLPLTALAPLRFERSLKLIRDLLILEE
                     RLSSSGTRLSEQLHAVIGTLAGAELRRPRQLLIELRRAIFQGRQPAPVQLAPDLLALLP
                     AELKAAIMRWQEVLQQHAALLAEARRLFAAELEERRAALRALAGQERFLQGLLLASPSL
                     YLDCCRWLAAAPAEAGRYLDRKLEDGLLNYLTRMAAKTSPYSTFTALARGRFVPAQAQW
                     EEVTAPVAVQDEPERGRSVIELNMLLVHHIARALARWPAVRPYLSVSVNPSLVSDAGLL
                     RFISRDDLGRESLATVRATAALQTVLRLVERRQPLTYGELLEALSALDPQERRQELAGF
                     LDQLIARGLLQLDFAIPEQAHNYLLRLCEMLAPIDQVQVQALRARLLELLEALAAYERA
                     ARAHQRYALLQQLRALLERLLAELGLSEQPGFALPTKNLIYENTLLEEAPGSSLPALES
                     DLLADLALVQGLAGLFDPLLTGRLALTAWFSRRYGEGATVDLLTFYADCFRESQQLGPA
                     VRNIPAEALLIPSTALSTAQVRPPFSALFAGSTCEQEELSRVMALRQEVARFVADQSPD
                     SAGVRFLDRQRLRALLEHCPASVKLPPSLALYCQLYWQDGQRGLVLNSIQSGFGRSLRR
                     LSYLEAHLAPSFPHSEHAEVDRREALASAEEPLPIAIQGVFGSNLNLRLPDGGYEIAYP
                     GCPSSGRRERLLPLSDLLVQHDPASQRLLLLSRRLNCKLLPIHLGLMSDYWLPPLYRFL
                     LWAFGETPGERLWSLRLLLLDQPLMPDHQGAGERQPRYRPRTCLGRICLERAHWHLPPT
                     CLPARQTGETHFDYFLKVQRWRTQYQLPARCFLRVNPFDFQAAGGPGEGPAYSLGKERK
                     PVYIDFESYFSLSLFEHLIAKGSFGLLLEEALPGETDLLPAREGGSVCEYVFEVNSEGA
                     "
     misc_feature    15921..15935
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.43"
                     /tool="antismash"
     aSDomain        16771..16956
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R35_RS01870_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-08"
                     /identifier="RREFam001.1"
                     /label="A4R35_RS01870"
                     /locus_tag="A4R35_RS01870"
                     /protein_end="356"
                     /protein_start="294"
                     /score="26.0"
                     /tool="antismash"
                     /translation="ATVRATAALQTVLRLVERRQPLTYGELLEALSALDPQERRQELAG
                     FLDQLIARGLLQLDFAI"
     gene            18686..19714
                     /locus_tag="A4R35_RS01875"
                     /old_locus_tag="A4R35_01815"
     CDS             18686..19714
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF025394.5"
                     /locus_tag="A4R35_RS01875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01815"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_189361229.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.6e-70, bitscore:
                     234.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRSWISAHLFYHGDLSALLKGCVQPLLTRLEQRGLIASSFFVR
                     YWQGGPHLRLRLLPQTASASAQIMDEVRQAAACYFQQHPAPDSLDVGRYEEISGYLAYM
                     EYGRAESGPLYPNNSLHFLPYVPEYEHYGGQQAMPAVEEHFGESSALALALLTQDADRR
                     QRTAHSVAALLLTAALEDPTRAATARVIEHFYFSWERMPASLRTRLLARFDQQYEEQRQ
                     RLEQLSEQLLRLSAQQESDLDDSATLLMRWLRSIRRLYRRLRELDQAGLLVSPQVPTTP
                     ARPVSAPLTILLRCAHMHNNRLGLLLLEEAYVLHLLKRALSEGGQTSGSDWQPEPLPGR
                     QL"
     gene            19730..20914
                     /locus_tag="A4R35_RS01880"
                     /old_locus_tag="A4R35_01820"
     CDS             19730..20914
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF045556.1"
                     /locus_tag="A4R35_RS01880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01820"
                     /product="thiopeptide maturation pyridine synthase"
                     /protein_id="WP_112425992.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.6e-68, bitscore:
                     227.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSSVAYSEGGDWQSVHVYYYAEQQNDALLLDCIQPLFVQARPI
                     TTRLFFVRHWLRGPHLRLRFYCSPTQFAVALKPLIESIVGSYLRQHPSSAHLDEEQLKG
                     LYATLARQEKEAGPFFPLYPDNSIQYLPYDRRLHVLGSEALASLLEDFYVDTNDLAFAM
                     LAHRRQGHSLLTLCFDLMITVAHRQGQHIARGFISYRSHAEGFIIASADPARMRTLLED
                     RYQQQAKTLVARLRQLLAALDREQDTFPFTLAWSRLMQRYQERAAQLIAAGQIDLSAAG
                     LETDNGGGPLVRGNLAASAFHSALERDQQHKQALYSDPWFQSYRLVLNLLYLHFSRLGL
                     RPIDRFLLCHLAANAVEEAFKISAVDMVSAFSEGALSGPPPWPGERGRQHHAGA"
     gene            20901..22607
                     /locus_tag="A4R35_RS01885"
                     /old_locus_tag="A4R35_01825"
     CDS             20901..22607
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.5"
                     /locus_tag="A4R35_RS01885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01825"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_112425994.1"
                     /sec_met_domain="PF00881 (E-value: 2.3e-08, bitscore: 32.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEPERALSPYEQRPQETLAPALQRYMAEAQHFPEREVVDWQHAP
                     LKYKIYRGCPCLRLAYLTPPTSEAGAEQGRQPFGGAQFGQMLADIYGLTRQRWTGAESY
                     NAIAAGSTLPILDPLKHPFKQDLLRPVPSGGGLYPCELYAVIGPAQALPAGVYHYDPVH
                     HALDVIQDADARPEQSGRFLERLLEALLEPPACAADFALVLSCFFWKNAFKYGEFAYRL
                     QGLDLGIVLGQSLAVGSYYGLKSSVHFRFVDGAVNALLNLDEAYESAYAVIVFSLGDTP
                     RGPGIGWQRWQKAAASPSSVTDERARLQPLSSLPLSAALHRASLIRTCAQGQPLTGQDQ
                     DAEESLRGALAGSGVALSDDIGLELARGTPLRHSARHYFRPGRISEQQCAQLLYAAGRG
                     LQSDIAPAASYLPRLLLYCIVAGVQGLDPGIYCYTPGARHWQLVRSGDRRLQLQQIVAH
                     TGYHNVYHINLHVFPVGEYSEGVRRYGPRWYRIQNMLAGSVIQRLYLAAALLGLGCHTS
                     LAYSIEGVNNLLGLERGATALAQVLIAPERLAGQYYEMPLPAVLAAALPEG"
     gene            22620..23603
                     /locus_tag="A4R35_RS01890"
                     /old_locus_tag="A4R35_01830"
     CDS             22620..23603
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="A4R35_RS01890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01830"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_112425996.1"
                     /transl_table=11
                     /translation="MHPTIERKEVSVVSGNSAAIISIESVHKSYGSLKALEGVSLYIGN
                     GECFGLLGPNGAGKTTLLSCVEGLISFQEGRITVSGYDVARQPRKVKSLLGVQLQDETL
                     FTDLKAVEAVQFYGALYNTFPTRAEALALLERFDLAEKSNARIGTLSGGQQKRLTLALA
                     MVHQPSIILLDEPTTGLDPQARHHIWDIVRRLRSEGKTIILTTHYIEEAEVLCDRVGII
                     DQGKILALGTPRELIERMGNLSTVRASLHLPTEKLQQLQTAEFVHAVSGDDGLLTVQTS
                     DPQRVLALLEEIGQELGSRPQNVSIRQPNLEDVFLSLTGRSIGPAD"
     misc_feature    23659..23673
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            23690..24448
                     /locus_tag="A4R35_RS01895"
                     /old_locus_tag="A4R35_01835"
     CDS             23690..24448
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.5"
                     /locus_tag="A4R35_RS01895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01835"
                     /product="ABC transporter permease"
                     /protein_id="WP_112425998.1"
                     /transl_table=11
                     /translation="MRRFITEFRFFIILAFRSRTLLFFSLLVPTGSLLLFGFVFGQNVI
                     PLPGSGGVSYSVWLLPGIIVMNMIASGLMGNSTAMITWRERGIFRRILVTPTAPWEVML
                     ARACTQVLVIVIQTIVAIIVGSLVFHFTFNPLYAPLTLLFIILGSAVFLLLGQVIASFT
                     DRVEIGNIISQGLYILLTFLTGILLPLQILPDIVSKIAPFTPSYMVAELLRSAMLQGNA
                     GSAPLADIVGCLLYCAAALGLSAAFFRMLH"
     misc_feature    23707..23721
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.9"
                     /tool="antismash"
     gene            24500..25747
                     /locus_tag="A4R35_RS01900"
                     /old_locus_tag="A4R35_01840"
     CDS             24500..25747
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014081.5"
                     /locus_tag="A4R35_RS01900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01840"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_112426000.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 4.6e-30, bitscore:
                     103.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYTILRDVCLVEGASQEGIRKGCDLWLRGGSIEAITDSRARLPL
                     RGEGEEIPCSGLYCLPGLIDMHTHVTSPGEERIEESDDFRRLLAEHGRQALGAGVTTLR
                     DLGGWPEVLLRLRAGAARSPFFPNLVVAGPFLTAPGGHPTIGLFHGLSALRRAATRELS
                     EPEQARAVVDQLAASGVDFIKVVSTACLIVPQEEAQVPKLRPEIFAAIVAAAHAHGLKV
                     VAHTMTAADVREAVRVGCDGIEHGIVCDAVEAACEPELLDQLRERQICYVPTLAAIEQL
                     APRFLEQAMQNARRLAEQGVLIGVGSDAGNPGVPFGAGLLRECELLFAAGIPPAQIIAG
                     ATSCAAEQLGRGGQLGRLSPGYQADLVLLRANPLEHPGHLRQIEAVFKAGCCVAARPAS
                     VFRRQHPSASFQESVS"
     gene            25744..26265
                     /locus_tag="A4R35_RS01905"
                     /old_locus_tag="A4R35_01845"
     CDS             25744..26265
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS01905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_01845"
                     /product="hypothetical protein"
                     /protein_id="WP_112426003.1"
                     /transl_table=11
                     /translation="MSQENLLPLSSLQRRQGRFGFNAVSVAEGLFALGVLALLISVFLP
                     WRYSVLNRPGEPVLVLSGWQTGLLGGQGLCLLAGAVLVLLLALRRWLAPGQRALWEIVA
                     AVLLGAITVVTFKDVLDFYSGSLALVIKHSVLGAGFYGAMLGLDLLLFACFLLVRRRQR
                     QAEPGQQSAR"
     misc_feature    complement(26469..26484)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            26861..27523
                     /locus_tag="A4R35_RS01910"
                     /old_locus_tag="A4R35_01850"
     CDS             26861..27523
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS01910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_01850"
                     /product="hypothetical protein"
                     /protein_id="WP_146747086.1"
                     /transl_table=11
                     /translation="MAVSPASIAGQSCGTELTVTYTATFHVVPDQGTHTVQFAYTTNNG
                     RSQQFASLQFLPGQATKTFSFSWHGALPLDHTAPGLGGVLVTSPNQLISTPVKPAGLCT
                     PAPFHVTSVTMSVNPGTIAGLHCGTNLKVTYTATFHIAPGSLGGIIKFGYTVDNGRSGG
                     DNTQTLVVGPGATTQTYSFTWSGVLPADHTFPEPGGVLVSSPNVVRSPLVGPSGQCS"
     gene            complement(27934..28884)
                     /locus_tag="A4R35_RS01915"
                     /old_locus_tag="A4R35_01855"
     CDS             complement(27934..28884)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="A4R35_RS01915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01855"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_112426007.1"
                     /transl_table=11
                     /translation="MNEREAAAAPIHHVEPQPSPSSTSSRNTYIIDSEQAAELARLMQQ
                     DRLLTEAMGGLLPEEGINLPERGRVLDLACGPGGWALELAFRFPKVEILGIDISPLVIE
                     YANAQAWSRGLENVHFQVGNVMDPLPSPDQSFDLINGRLLFGFMLPAAWPRLLAECFRL
                     LKPGGILRCSETEPPLTSSPAFERFSALGTEALKRAGQSFSPDGRHIGITPVLPRLLRQ
                     AGFERVRLRASAIEWSMGTEGHYPVFKDYLIGLELVQPFLVKVGVATAEELAALYQQAV
                     AEMQEEDFCALWTLLTVWGEKPATANQSEASPTAG"
     misc_feature    complement(29234..29250)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.24"
                     /tool="antismash"
     misc_feature    complement(29255..29264)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.59"
                     /tool="antismash"
     misc_feature    29263..29272
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.08"
                     /tool="antismash"
     repeat_region   29479..30469
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=426357..426393
                     /rpt_unit_seq="ctcagaatcagagaaagagcccgtttgggattgaaac"
     misc_feature    complement(30140..30154)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(30209..30222)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    30209..30223
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.0"
                     /tool="antismash"
     misc_feature    complement(30213..30227)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    30404..30422
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.86"
                     /tool="antismash"
     misc_feature    complement(30679..30692)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.95"
                     /tool="antismash"
     gene            complement(30841..31959)
                     /locus_tag="A4R35_RS01925"
                     /old_locus_tag="A4R35_01865"
     CDS             complement(30841..31959)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007914347.1"
                     /locus_tag="A4R35_RS01925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_01865"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_223258148.1"
                     /transl_table=11
                     /translation="MSSDTQENRAEMLAAIKRELRKSNSFGAAFFRVAATQAGLAADTD
                     IQVLDLLDLAGEVSAGQLAELMGMISGAIAKVLNRLEASGLVYRERDKSDGRRVIVRLT
                     AGKEELRKVRAMLAALEETWDEVISSYNEEQLAFLLAFLQRSNTLSRQQLLQLQETALP
                     EERSIFSAPLDDLPQGRLVFLSAGIRLVLRTSSEMAELYQARFKGAVPNVTVQGGVVTI
                     RYPRQFLLLTGDQRQAEITLNGSIPWQIVVQSGGSDVFADLSGLNLASFEVRGVGSQIL
                     LQLPVPSGVVPIRISGGGSEIVVQRPAGVAAQAHLKGWGSAWAFDGQTYMGNKLRLSSA
                     GFDPADPYYLIEVTSSGSTVTITSLEAGGELK"
     misc_feature    31991..32003
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.71"
                     /tool="antismash"
ORIGIN
        1 agtttggcca tgaaactgca ccagctcgga gacgatgctg gcgttccagg cgccgccact
       61 ggccgtaatc agcccggtga ccaggtacgg gaagatggcg ggcaggatca cggtgcgcca
      121 acggcgccag ccagtcaccc caaagagggc cgcagcctcc agcaggtcgc gagggatggc
      181 catcgccccg gcaatgacat tgaagaggac ataccactgg gttcctaaca gcatgagcag
      241 gatcgccgcc agcgagaggc tgcctggcag agcgaccaga agagccagca gcgccgggaa
      301 gagcgctgtg gccgggatcg aggcggcaat ctggaccagc ggctgcaggc ggcgtgacca
      361 gcgaggtgaa agaccaatcg ccacgccgat gggaactgtc cacagagtgc cgatcgccag
      421 ggcgatcaat gtgcggagcc aggtcgctcc ggcagccagc accaggcgcc cccaagtcac
      481 aggtggcacc tgcatcagca ataaccctcc ttgccagctg atccagagca ccagcaatac
      541 gagcaagccc aggaatagca tgcccgcgct gcgcagcgcc cagtggagaa gccgatcttg
      601 acgggcctgc tctaccgtgg acgggtgtgt gaacctgtct cccggcaatg gctgcaggcg
      661 gttgagcaac caggccagcc cctccccgag cggctggccc agatgcttcc acagccagcg
      721 cgcggttggc gagcctcgaa ggagatcgag caccagcgag tgcggcggaa tcgtctcggc
      781 ctgctcttcc agcttaaagc gctcagccca ggccaccagt ggacgccaca ggcagacatc
      841 gagtaagaca atcagaccga tcaaggtgag cagcccaagg gtaagtgccc tgggatcacc
      901 tcggtcggca gcgagctgca ggtaggagcc gaggccgggc agttggaagg agcgatcccc
      961 cagcgaaaat tgctccgagg ccatcaggaa gaaccaccca ccggcccagc tcatcatgct
     1021 gttccagacc agaccgatga tggaagcagc aagctccagc ttcaagaacc gctgccaggg
     1081 tcgtaacctt agcaaacgac agacatcgac cagatcgcgg gggagtgtca gcacagaatg
     1141 gtagaagcta aaggtcatat tccaggcctg gctggtaaag atcagcagga tactggccaa
     1201 ttccagcccg atattgcttt gcggaaacgc tgccaccaga gccagcacca ctgctgggag
     1261 aaaggagagg atggggatac tttgaagcag atcaagcaat ggaatcataa cgtgctcggc
     1321 ctggcggttg gttgcagcca cgtggccata gagcaaggtg aagagcagcg ccagcccata
     1381 agccaggagc atccgcagca gggagtaacc ggcatagagt ggcagcgcca gcggtgagag
     1441 cgagatggca accaccggtg tcaggggagc ggcccaacgt gaggcggcca gcacaagcca
     1501 ggcgcacaac agaaagagaa agctccctcc tagaatcaga tcccgtagcc agagccagtg
     1561 ataaatggct gacccggata ggccgcgccg gcttcctcgc tgctgcggga ggacgtgaag
     1621 cttgcgagtc atgatgcctc tcctgtgcct ggtgagatag gccaggacga tcatgcccat
     1681 cactggacgg ccagggtgca tagctggcgt gagcagacca tcacaaaagc aagcatgcat
     1741 gcctgagcga aggcatagct tccctttcca gcaggtaccg actactggct tccaagatgg
     1801 ccgctcactg cgcgtgagca caggagagct tccccacgct caggtcaggt atagcgcatt
     1861 ggcagcagct ataacgttgt actgccgggc cgggtgcctc ttgagcgagg gtcaagcgac
     1921 cgattgttgc caggcagaca gaggccggct gcaagtagca gaactcgatc ctgatgagcc
     1981 tgcaacactt cgtagaagga taagaaagtt aagatccgag tcagcgctca cgcgagaaaa
     2041 gagggatgag gtgaggagca acactgaggg aagggttccg agggaggagt ctacgagcag
     2101 gtgtcctgct tcagtcaggc ttccaccccc tgttcccgtc agcactcacc cattccatgc
     2161 gtaggaaggt ccctcgccgt ggcggtggtt ccgagcatct actcgccggt tccatagatg
     2221 gtcacgatcc tcctgggctt tggcctggtg tgatagcggc ggactctctg cccgagcttg
     2281 atctgcctac tggggatctc cacaagccac cataccaggc ccatttttga aacgagataa
     2341 tctctgcgaa gaattatata gctgccggag gaaggcggtc aagggtcttg cggcgaactc
     2401 gaagcaagcc agagagttcc ttgcatactc gcgcgacggg acacgatgac cgtcggcccc
     2461 tggtcaaggc gcgcgggaat tcgcctgtcc cgagccggct gggatgatcg tctcctgcca
     2521 gaacgtggcc ctcgccactg ctcggaacga gcggtcctgg taactaactg aggcgatcgt
     2581 acgggctgag gagggcacta gaagcgctca tcggccacat ccgctgatgc tggcggcgcc
     2641 agtcgggcgg gaaccactca tcccgctggc tggcgccgcc tgacagtaca ggaccccatc
     2701 gccgagagcc tggtcggcct gagtgcacac gagactgcgc gctcttagag aggctgctcc
     2761 cggccctcaa gcgtttgagg accgggagca acatgccagc caggcttact gatcagccag
     2821 tcagccaaag ccggcctctc agtcgaggga tcaagctgaa ggcgtcagat ctcgatcggg
     2881 tacaggcggc gccgcggcag gctggcacga tctggctcct gaaagccctt caagtgccgg
     2941 gactccctca gacttctcca gaccggcagc cggcaccggt tgcaccctcc tctcagatca
     3001 gagcgccgtc cagccaacaa catcaaccgt gccgttgctg gccgtcgcta cggctacagg
     3061 ttccccaccg cttagactcc cgtagaagac cgtcgtttcc tcgatcaggg cattgccgca
     3121 ggctagcggt ttagctcctg tcatggcata gaggtgacca tcacgggaga tgagggacca
     3181 gagcgcaggc accgcctggt ccaggctata gctgctcccc tgttccaggt tcgccagtac
     3241 gcgaggccga ccacgaccat cgctgctgag catagctagc tgaaaggtgg cctggtatgg
     3301 tgcgccacac tggaggtacg ggctcccgtt acgcatgagc atcagtaacg tcctcgtcgt
     3361 gacggcccgt atgctctcta cgcagctttc gggattctgt gccgaagcca gctgacggta
     3421 gatggtcgtc tgagaacccc ccgctgctgg ctcgctcacg atggtggaga ttgctggccc
     3481 tgtttgctcg catgtagaga caaagagacg cgagccgtca ggactggtat ctactgctac
     3541 gtctgtatag cgaacatttt cttctattac atcattccac acaggattgg ctggattagg
     3601 gcttttgttg acatcgataa ggtagaggtt cattggtagc ggcggcgagc cgcaggtggc
     3661 acggctttct gtaacgatgt aggcctggct gctgttgagc caactcaaag ggatagcaat
     3721 cgagcaagat tgtgtgtata gcaagagctg tcgtaagttt ccggttctga tatccagaag
     3781 cgtcaccagg ctggtagtac cttgcaaatc ggtagacagg agaacatggc gctcgtcggg
     3841 agaccaggta aagcgaaccg ggggatagcc agtatagctg atgatgcccc gtccttcgaa
     3901 ggcgctgaag gccccgcctt tcggggtata gggcagctta gggaagcaat agagggtttg
     3961 gaggccctgt ccatccatgc gtaccatctg gagcagcgct acatggttgg ggtcgcgctg
     4021 tggatctggc aggctgagaa acataatcca ttgcccatcg gcggagacct gggcctcgct
     4081 aatgtgcaag ccgctggtga taatggttac tcgttgaccg gtggcaacgt cgtagcgcac
     4141 caggtggccg tgggcggtgg aggtttgcga ctggccttcg ttatagatgt agacaaggtt
     4201 ctgatggctt cccagagcca gcgggcgcat gactgccggg cgcgtaccga aggggttggt
     4261 gggcgagatg ccggggcagg aggtctgagt gactggcatg ggcacgcttt tccggggcgc
     4321 gggagtagaa gtcggtggat gttgtgccgg cctcgtaggc gttgctgtca gttgctggag
     4381 gccggagccg ccgcctccag aaatgctgat agatgcacta caacccgtca ggatgagaca
     4441 gaagaaaacc actagccagc ttattgtcct ggctgtactc cgtgcgatga agctcatggt
     4501 ttcacctccg caatgggcct cagatcctcg ttgagacgct cggaagcgta tgctttgggg
     4561 cactctcact gcttcattta gcatctgcag ccgcaggcag ctatgaaccg tttcacggtg
     4621 acattgttgc ttcgttcaca gctgcctatc taccggaacc agccttcctc accgccgtct
     4681 tcagatgagt cagggcttcg tgcagatcct ggcgcagaga ctggcggtga gaagtggagg
     4741 cctctcccag agactttcgg cggggctttc tcgtcgggga gtggggtcga tcgtgatcgg
     4801 ggaggtcttc ctgctgcttc tcgcttggct cagcgcgttg cattagcgga gcagccagaa
     4861 atcgcggcac tggatggggt gagaaggtag acgaaagcgc cgggcaacgt cggggtgatc
     4921 gacgaacgcc ggtgcttcat ccgccttggg aaggcgcgtg tcggcgttgg tatcgtggcg
     4981 cgctgcgacg acgaggggac tcgtaggtct ggctgggggc tatgcttgtg atgcagctac
     5041 cgcttgtttc aatcccaaag gggcaggata gctgcttcag acgcacaaat gtgtcgatca
     5101 tccgaggaca tcgccttcct ctttcaatcc caaaggggca ggatcgctga ttcagacaat
     5161 gctgctctcg gacgtggtag gaagtgagcc cgaggtttca atcccagacg ggcaggatcg
     5221 ctgattcaga cctgccacaa aaaacgacaa cagcacaaat aagctagttt caatcccaga
     5281 cgggcaggat cgctgattca gacctccgca gacacttgca aaaatcgcac aattacaggt
     5341 ttcaatccca gacgggcagg atcgctgatt cagacgctgg cacccgactc gggcgctggc
     5401 tgcattcgtg agtttcaatc ccagacgggc aggatcgctg attcagacgc atgaccgaga
     5461 acgagatgag gcagatctat cgggtttcaa tcccagacgg gcaggatcgc tgattcagac
     5521 gaacatctgg ccctcttggt gttggcgagc aatgctgagt ttcaatccca gacgggcagg
     5581 atcgctgatt cagacgctgc tgctgctgaa gttgctgagg agactgctga aggtttcaat
     5641 cccagacggg caggatcgct gattcagacg taccactccc aaaatgccta cttctaaaaa
     5701 tgctgccgtt tcaatcccag acgggcagga tcgctgattc agacgttcga ctcctgcgga
     5761 tgaaggcgac ctcgcctatt atggagtttc aatcccagac gggcaggatc gctgattcag
     5821 actgtggccg gactgtccgg cgctcaccgc cagcaagcgt ttcaatccca gacgggcagg
     5881 atcgctgatt cagacgcgct ctccctgttt ctcgatcacg gcgagagtat cgtttcaatc
     5941 ccagacgggc aggatcgctg attcagacgg taccccttct aagatagcat ctggagcggc
     6001 ctccgtcaag cagattcgat gatcccaaaa aaacggtcac tagtgaccgt ttttaggcgg
     6061 taatcatgcc agccactttg gccctccggc ggcctgggaa gcctttcgag gatcgctgcg
     6121 tgagaagtcg ggagccgaga tcctcgaagc gacaagtata tcaggtaaaa atgtaaaata
     6181 tggttttatc gaatagtatc cataaaacca ggcataacca tccgagcctg ggaaacctgc
     6241 ctgtcggcct gctggctgac gggctgacca gcgataggct cctgcggcat aacagagcct
     6301 ctaagaacag gaagccagca cgcagccgat tccctcgtac aggagcgtcg cccgggcctc
     6361 tcattcagaa agaaagaact cgctcgctct cagtggcgca aaaggctggc cgctcggctt
     6421 tccctctgat caaaccagct cttcccttgc cgagcaccct tgactctgac gcaacgttat
     6481 ggagcggcat atgtcaagga ggcgaaagcg gtgaagtata cggttgagct gactgtttct
     6541 ctgcccgagg actccgtgcg agcaagtccc ccacgggacg cccgtagaga aagcgctcgc
     6601 tcaccatctc agtctgaagg ctaccccgtt caggggccag gcccgtcccg cagacaaatc
     6661 cgcccgctcc agccgggctg acgtctctgt tctgcattag gaaatcataa aaaatcaata
     6721 atcaggcgtt atagcaatcg cttctcgttg acatccttct tctcctttcc tagactgaca
     6781 gtgttcgctc tccatctgtc ctcattcata ctggctcttt tcggacagag caggaccaga
     6841 tgagatgaca aggaggtagt agtatgccct ggtggttctt cagacgcaag cgcccaacag
     6901 tgccccagag cagtttgcca ccggtctctg acgcttccga aacagcccaa ttttccagtt
     6961 gggccaatgt gaccactcta gccgaccgta ccgatacaga tcagcgccgc tatcttgagg
     7021 agcagcccta tctgctgccc aaggacctgc aggaagtcaa ccgtctcgac tttcagcact
     7081 acgtgctgcg cgctgccctg cgccgcaact atctggcccc catccaggcc ccgcgccaga
     7141 tccttgatgt tggctgcggt actggacaat gggcctccga gctggcgcgt gagttccccc
     7201 aggcaagcgt agtgggcctg gacgtggagg aagcgaagca acagacagct cccccgccca
     7261 attaccgctt cgtcaaaggg gatgtgctca atggcttgcc cttcccagat cactccttcg
     7321 atttcgtcca tcaacgcttc ttgtggacag cgttgcccct ggcagcctgg ccccgggtgg
     7381 tgcaagaact ggcacgggtg accgcccctg gcggctgggt cgagctgctg gagcctggcc
     7441 tggaagcggc tcctatgggg ccgacgcatc gccggctgga tgccatgatt aaggaactgg
     7501 cagcgctcag aggactggat ggagaggggg ctgtcaccgc ctcgctggat cgctacttgt
     7561 gggaggctgg tctatcacag gtgcagcgac aagtaatcga agtccccttt ggagactggg
     7621 gcgggcgcat cggctccctg ctagccctgg acttccgcga gttcgccctg gccctgagcg
     7681 gcgcggcaac aaaacgcttt cagctgagtc accagcagta tcaggcgctt gttcagacca
     7741 tgctccagga gtgcaatgag ctgaaaacaa tgtatcactt tgttgccgcc tatggacgga
     7801 aactctgatc cccccagtcg tcccttgaag aaggaaagcc tgcctcacct cagtctcgcc
     7861 ttcctgcgcg agtagagcag gagaatgaag gaaaggtaca gacagacatg cggctggccc
     7921 tctcgcccct ggcaccaatc cagtaaccat tgtcgcgcca ggggcgagaa ggccagccgc
     7981 aggcgctcag catggggcgg gtgggtccag catggggcct ggcgatgggg ctgcccgatg
     8041 gcgcttacag acacaagagg ggatcacagt gagtgcagtc aggtcaattt ttcatgccta
     8101 tactgctgga tcggaagaat aggcaaggct cgcgcttaca gcctttcacg ttcaccaaac
     8161 aagagaggtt tcaccttacc cccgggcggg gctggcaaaa gctccagaga ggcgactgaa
     8221 cgtcttcttg atcacttccc tctctagact cgctacccca cttgacatta actccaccat
     8281 aatggtatat tcgaagcgtg agcatgaaga gcctccatct ggatagggag gcatcgagat
     8341 ggacggtcga aagccaggca ggcctggtgc agatcgcccg actcctccgt cacaatgcga
     8401 acgtcaaccc acctgtcctt tcctgggggg gaaaggccca gggcgaaggt tctcttgagt
     8461 tcgccatgct cgcgcccagt tcctcagatc gctgtcaggt agatcgcttc caggcaggct
     8521 cagccatgct ggatggcagg ctgggtaatg aatagagaaa gagaaaaact tctatcttgg
     8581 gcctgagccg tgctataagg ctggtctacc atgccaaatg acatctcact caagagcaat
     8641 gctgctcggt gattggatgt gaaggagcat ctgcctagta ccgtcaggtg tatcacaggg
     8701 gtgattgcca ttgcaatctg gctgattacc agcgccggct ccgcacgatc agatatgtta
     8761 gaggccgcgc ccatagcctc gctagaggca taccactcct tctcgtctcc ggtcatccaa
     8821 gcaccagcac ccaaaactac gggcatgagg tgatactgcc ctcttaaccg ctagacgtat
     8881 tttttagatc cgtcgtgtat cgctcgtcaa gagcggcaga ggagcagttt taccttcata
     8941 tagctgcaaa tagagctttt gaagagaaag gagtctgaaa tgaacgaact gcacggcgaa
     9001 ctcgcccagc tagaactcga aggcctctcc ctcgataacc tggagatcga ggatctgaag
     9061 ctttccagcg aaggcggcct ggagctactc acgaccggcc acggcatggt ggagatcggt
     9121 gcctcctcgg gccagaccgc ctgctgtagc tgctgcattg tctgctgctg ctgcccctgc
     9181 ctgggttaag taaggctcac ccctcggcaa gatattcagc gccggtcgac agactgatcg
     9241 gcctcccgtg cgggctagcg gttgacagca gggcagacgt cgcttcatgc cacaagcgcc
     9301 atcccatcta catgatgtgc aaggaggtta ctcatgcaag atctgcacgg cgaactcgcc
     9361 cagctggaac tcgaaggcct ctccctcgat agcctggaga tcgaggatct gaagctctcc
     9421 aacgaaggcg gcctggagct actcacgacc ggccacggca tggtagagat cggcgcctcc
     9481 tcgggccaga ccgcctgctg tagctgctgc attgtctgct gctgctgctg gtaatcgcca
     9541 attaattaag ctattgataa ctgctctccc tgcctgctga ctgaggcgat acacgacctg
     9601 cccgccggga gaaaggagat cgcagcatgg aagatctaaa acaggaactg gctcacctga
     9661 cccttgacga gctgcagctg gacgagctga acatccagcc gctcactgca gatcgtgatg
     9721 ggctggaagc gctcaccctt ggtcacggca tgatcgagat aggcgcctct gtccttcccg
     9781 agggctgctg cagctgctgc ataccctgct gctgttgctg gtagcaagct gcaagacaga
     9841 gatcgagagc gccggcggaa ataaaccagg ccggctctcc tttacctggc ctatctgagg
     9901 tgcagcgtag ttgctgagcc gctatgctgc acctcacgca ccatcagccc agcccgtcgc
     9961 cgcagggcat ctatgcgcac gatgaggaga gaaactggcc atgcgcccca ggatgagagg
    10021 cgatgtcttc tattttccta cccctgaagg ggtttacctg cgtaacaatc aaggcgcctt
    10081 ccacttgaga ggcaaaggcc tcgctcgtct gctcgacttg cttttgccct atctggatgg
    10141 tcagcataca ctggacgaga tcactcagca ggcgccaggg gagcagcgcg ccttgatcag
    10201 caagctcatt gagatgctga ccgctcgcgg cttcatcagg gatctgaccc ccgatcatcc
    10261 ccatcagctg agtgctgcgg agcaggagac ctacgcggcg gaaatcgctt tcatcgaggc
    10321 atttcaagat tcgagtgcct ggcgcttcga acgctaccgc cagagccgcg tgctgctcat
    10381 cggttccggt ctgacgctcc aggcgctggt gcaggccgcc ctgcatagcg gcctggcaga
    10441 catctctgtg ctgatcacag gcgagtgccc gctggatcgc cagcgtctgc aggaatatct
    10501 ggctctgcgt cagacgcgcg atccgctcca gcagcttcac atactagaac cgctcaattg
    10561 ggacgatgag cagactgtgg cgcgcactct cgcacccttt gaggccgtcc tgcatctctc
    10621 agatcgacca atgctgcggc gcagcgccct gctcaaccgc ctctgctacc aacaaggcaa
    10681 actcttcctc agcgcgacca tcctggacac tcaagcctgg ctgggaccgc tggttcttcc
    10741 cgctcccgct cctgggggac acgaagctag ccgcggctgc tgggaatgcg cctggctgcg
    10801 cttgctggcc aatctgccgc ctgaaatggc cacgaccctc gacgacttcg ccgatcaccc
    10861 cgagactccc ctgagttatg cgctggctgt gccaaccgct gccgtcgtcg ccaatactct
    10921 caattttgaa ctatttaagt atattactga agcaggaccg ctggagacga gtggccatct
    10981 gctcttcatc gatctggaaa cactgcagag ccagcgtcat ccattcaacg cctctgccca
    11041 ctgccgttgc tgccgccagg ccggcccgct gacagcgtcg tacttccgtg acctggtgag
    11101 ggagcgcagc acagggcctg tcctctctca ggaagacttc tctcgcaagg cggcccgcct
    11161 gttcgatgcc aggctagggc tgttcagcgc cctggatgag cacaactaca ctcagattcc
    11221 tttaaatata gcgcgcgtag atctggcaca gccagcgcct cgtctgtcca gaggagagac
    11281 ctggcgcgtt ttcggcgccg gcagcgattt tggagcggct cgccgggcag caacgttgcg
    11341 cgcctgcgag tgctacgctg cctggtgcta tgatccccga cgcagtctga gcgggagtgc
    11401 gccagaactc gttggcacag ccccggaagc cttcacctgc tacacacgca gcctggagcc
    11461 atcgaccagc ctcgacccgc aagaagacta cctctgggcc tgggagctgc cgggcgagca
    11521 ggtcgccctg gttccggcag cgacggtctt tccgctgtcc actgaggaag agcgtcttca
    11581 gctgccgccc gtcggggtgg ccgccggcat gagctggtcc gaggcccttt gtcgcgcgct
    11641 cttcacttat ggatgcgcgg ctcttgagca gcgtctggca cagagtcgcg aaccctttcc
    11701 ccaggttgag atcgaggccc tgactctctc tgaggccgcg cagcgctaca ggcatttgct
    11761 ggccttgcaa gagatcgcca tcgctgtcta tgatctctct gccctgctct ccgactgggg
    11821 gctgctggcc ttcgctttct gctgcaatga ggagacctgg acctatacct gccacgtgca
    11881 ggtccaggcg gccatcgaag agggtctgcg cctttgcctt cagcacgctc aggctctgcg
    11941 gaatagtgag tcggactatg cgctgttgcc ggtcactcct ctaccgtcag cgctgcgcgg
    12001 cgagaccttg atcgctcccc cctatccgcc ggtagaagcg tgggagcaga tgctaccggc
    12061 cctgctcgct gccctgcagt cacaaggacg gagagcgctg attgtgccac tcgatcacga
    12121 tgcggcgctc actgaggcgc tgccctatat tgtacggatt gtgctgggga agaggagggt
    12181 cgacgatggc cgctgatctg aagaatgcac aatccaggcc attgctgggt ttgctggccg
    12241 aaggtcaccg cctgggtcag gccgtccgtg aagtcttgcg cgagtggggt gaacctgtgg
    12301 aggtcaccca ggccgatctg cgggcggcgc aagtgccggc ctgcacgctg ctactggtga
    12361 tctgtgaggg ctggcatggg ccgctgctgc gggaggccaa tcgctggagt ctggccagcg
    12421 gcagaccctg gctggggcta tcgatcgagc caggacgcgc cgtgctcggc ccgtgtgtct
    12481 tgccggggca cagcgcctgc ttcacctgcg ccgagctgcg gcgggtcaac gctcacaagc
    12541 gggcggaaga atttcaggcg gagcgggcct atctggaaca gcaggcgtgc tcggagctgc
    12601 aaccagatgc ggtttctgcc ccgaccagaa cctggctgac ggcctttgcc caggccatcc
    12661 tggcgcagca ggtcgcgcgg gaggtcgcgc agtttctgca ggccccggag gccatgctaa
    12721 cctgcaatgc gctgctttat ctggatctgg caacgctgag aatcagccgc catcccttcc
    12781 tgcccgagcc gcactgtccc gactgctcag ccctacctgc cgatagcgct gctgccgccc
    12841 aggcggcgat gacgctcgtc gcgcggcaga agctcgctcc tcagacttac cgtgtgcgcg
    12901 atctgctctc tctcaaagat cgactgctgg cgcgctacgt cgatccagag tgtggtctga
    12961 tctgcggcct gaccaaagat agcagcaatc tctatgccaa tttcgccgcc cacatccact
    13021 ttcagcaggg aaggcgtcaa gaggtgggct ttggcagggc tttcaactac gaacagggtc
    13081 aggtggccgc catcgccgag gctctggaac gctacgccgg tatgcggcca ggcggcaagc
    13141 gtacagcggt gcgagcctgt cggcgtgaat tgggggaggc ggctattgat ccgcgcacgc
    13201 tgggcttgca cagcgaggcg cagtatagcc tgccccattt tccctatgtg cgctatagcg
    13261 atgacctcgt gctcaattgg gtctggggct attccttcgc ccgccagcag ccggtgctgg
    13321 tgcctgaatg caacgtctac tatggtctcc actattggac gcacgagcga ccgtacgtct
    13381 atgagatctc caacggttgc gcgatcggca actgcctgga ggaggccctg ctgcacggta
    13441 ttctggagat tgccgagcgc gacgccttct tgctgacctg gtacgcgcgt ctgccgatgc
    13501 cgcgcatcga gctgcagtcg gcccgcgacc cactggtcgg gctgatgtgc gagcgcctgt
    13561 atcatctcac gggctatagt gtccatgcct tcaacatcac cctgccggag cgcatcccct
    13621 gcttttgggt gatggccgtc gatgagcagc aacgtccaga ctatccgcgt gcgttgtgtg
    13681 ccgctggctc gcatctgctg ccagaaaagg ccctgatcaa tgctctgcag gagctggcgc
    13741 cgatcgttgg cagccatatc agtctctacc gccaggaacg ggagcacgcg cgcggtatgc
    13801 tggccgactc ctcgcgtgtg acccagatgc gcgatcatgc cttgctctac tgcctgccag
    13861 aagcctttga gcgcctggcc ttcctttacg agacgccaca tcagcagacc tttgccgagg
    13921 cgttcgacgg cgatgagccg cccactcatg cagatctgcg tgaggatgtg ctggaggtga
    13981 tggggcgcta tctgcgcagc ggcatcgatg tgattgctgt cgatcagacg acgcccgaac
    14041 tggcgcgaga gggtttctgg gccgtgcgtg tgctgatgcc gggtatgctg ccgatgacct
    14101 tcggtcacca tgcccgccgc tgctacggct tcaagcgtct ctatgagttg ccttatcggc
    14161 ttggttatgc agcgcggcct ttgaccgatg ccgatctcaa tccctatcct catccattcc
    14221 cttgagcgag cggaaggagc gagcacctat gagcaaccaa gatcgtgaga tcggtctgcg
    14281 ctatctgcag gccacgtact acggcctgcc ggaactcttt gctgaggggc agggcgagga
    14341 aggcatgccc ggcgagccac tcaagttcaa gatctatcgc ggcgtccctc attatccgct
    14401 caaccagcgc cttccgctct ctctgggcga tctacggcgg gccttggcca gccaggggca
    14461 ggacacccac tgtggagcgg gaccgcgctc cctggatgat cagacgctct cttgcctgct
    14521 ctactatagc tatggcttct cgcgtcatga cagcggcctc gatgcgcgct ggcccttcca
    14581 tcgtctggtt gcctccgctc gctgcttttt tcctgcagaa ctctacgcct ggttgccagc
    14641 atcggcccct atcccgccag gcttttacca ctatgacaac ctgcatcaca gtctggctgc
    14701 cctcagacag ggtgactatt gcgctgtgct gagcgccgcc cttggctgcg aactaacaga
    14761 cagcctaggg gtgctctttg tcagcgctta cttctggaag aacgctttcc gctaccgcaa
    14821 cttctcctac cggctatgct cgcaggaagt gggaatggtg gtcggcaaca ttctgctggt
    14881 ctgcggtgta ctgggtattg cggcccgggt ccactatcag tttctcgacc gcgttctcat
    14941 ccgtctactt ggcctggagg atggtgagga gagtcctttc gccgctgtgg tcctctcgcc
    15001 cgccgagagc gagcgagagg cgacgaagac gctgcctgcc cccgcagtca gcgctgaggc
    15061 tctgctgagg gaaatcgcgc cgattgcccc cgcccatgtc aagctgagcg cgcttgaccg
    15121 cgagcgctgc cagaagctgc tggagatcga ccagcactca cggttggaga gcggcgccga
    15181 gctggcggtc tcactgccgc ccgccacgtc ctcctgtgac caggctctcc ctaccctaga
    15241 ggcgccggca ccctggcccg aggagcttga gctggtccag gctctctacc agcgcagctc
    15301 gggcgacgtc tttttcctcc ccctgtacag atctgtgagc cgggccgctt tctgggagat
    15361 tgtccgttac agtctggccc cttacgccag cgatctcggc ggcgtggata ggaggaggcc
    15421 cgctctggag ctttttctgg cgctcaataa tgtcgctgat gtgcccgcgg gcatctatcg
    15481 tctctgcggg agctgtggcg cactgcatgt cgttgaacag cgcgctgtgg ctgctcagat
    15541 ccaggccatt cacagtacgc ccgctgtcaa ctgtggcagc gccccctttg tggcctatcc
    15601 ggttgccagc tacggcgcgc tcagcgcagc gctggggaac cgcgcctacc gcatcatgaa
    15661 catggagtgt ggcctggtgg cgcagcgtct ctcggtcctg agcgcggcct ttggcctggt
    15721 ggcgcgctgc agcgatagct atcatctcga ccgctgtgcg gagctgctgc atctgcgcga
    15781 gcgcgtagag acgcccttgt ttctgatcgc cttcggctat gagcgccctg gcgcgggggc
    15841 cggggcacgc taccgacaca gcattcgtct ctgaagagaa gaggaggcat gaaagagcag
    15901 cacacctgca gcgtggcggc ggaatatgtg gtacgggtgg ccggcctgcc gctgacggcc
    15961 ctggcgccgc tgcgctttga acgtagcctg aagctgatca gggatctcct catccttgag
    16021 gagaggctga gcagcagcgg gacccggctt tcggagcagc tgcacgcggt aatcggcaca
    16081 ctggctggtg ctgagctacg tcggccacgc cagctgctga tcgagttgcg gcgcgcgatc
    16141 tttcagggtc gtcagccagc gccggtgcag ctggctcccg atctgctggc cctcttaccc
    16201 gctgagctga aggcggcgat catgcgctgg caggaagtac tccagcaaca cgctgcgctg
    16261 ctggcagaag ctcgccgcct gttcgccgcg gagctagaag agcgccgggc ggctctgcgc
    16321 gccctggctg gtcaagagcg ctttctccag ggcttgctcc ttgccagtcc cagcctctat
    16381 ctggattgct gccgctggct ggcggcagct cctgctgagg ctgggcgcta tctcgatcgc
    16441 aagctggagg atgggcttct gaactacctc acgcgcatgg ccgccaaaac cagcccatat
    16501 agcactttta ccgcgctggc ccgcggtcgc tttgtcccgg cgcaggcaca gtgggaggag
    16561 gtgacggctc ctgtcgctgt gcaggatgag ccggagcgcg gtcgcagtgt tatcgaactc
    16621 aatatgttgc tcgtgcatca cattgcgcgc gctctggccc ggtggcctgc cgtccgcccc
    16681 tatctgagcg tgagcgtcaa tccttcgctt gtcagcgatg ccggcctcct gcgcttcatc
    16741 agtcgggatg acctgggacg cgaaagcctg gccacggtgc gtgccactgc ggccctgcag
    16801 acggtgctca ggctggttga gcgccggcag ccgctgacct atggagaact cttagaggcg
    16861 ctcagcgcac tggacccgca ggagcgccgg caggagctgg cgggctttct cgatcagctc
    16921 atcgcgcgcg ggctgctgca gctcgatttt gccatccctg agcaggccca taactatctg
    16981 ttgcgcctct gcgagatgct cgctcctatc gatcaggtcc aggtgcaggc gctgcgtgcg
    17041 cggctgctgg agctgcttga ggcgctggcc gcttacgagc gggccgccag ggcccatcag
    17101 cgttatgcgc ttctgcagca gctacgcgct ctcctggagc gtctcctggc ggagctgggc
    17161 ctcagcgagc agcccggctt tgccctgccg accaagaatc tgatctatga aaatacgctc
    17221 ctggaggagg cccccggcag cagcctgccg gcattggaga gcgatctcct ggctgacctg
    17281 gcccttgttc aggggctggc cggcctcttc gatccattgc tgacgggacg cctggcgctg
    17341 acggcctggt ttagccggcg ctatggagag ggcgccacgg tcgatctgct gaccttttac
    17401 gccgactgct tccgcgaaag ccagcagctc gggcctgcag tgcgcaatat ccccgcggag
    17461 gcgctcttga taccgtcgac tgccctcagt acggctcagg tgcggccccc cttcagtgct
    17521 ctcttcgccg gcagcacctg cgagcaggag gagctgagcc gcgtcatggc cctgcgtcaa
    17581 gaggtagcgc gctttgtggc tgaccagtcc cccgatagcg ctggtgtccg cttcctggat
    17641 cgccagcggt tgcgtgctct gctggagcat tgtccggcgt ctgtgaagct gccgccctcg
    17701 ctggcccttt actgccagct ctactggcag gatggtcagc gtggcctggt actgaactcc
    17761 atccagagcg gtttcgggcg cagcctgcgc cgtctgagct acctggaggc tcatcttgct
    17821 ccctccttcc cacattcgga gcacgcagag gtggacaggc gtgaggccct tgccagcgct
    17881 gaggagcctc taccgatcgc cattcaaggc gtcttcggct ctaacttgaa cctgcgcttg
    17941 cccgacggcg ggtacgagat cgcctatccc ggctgtccga gcagcggcag gcgcgagcgg
    18001 ctgctccctc tgagtgacct gctggtccag cacgatccgg ccagtcagcg actgctattg
    18061 ctctcccggc gcctgaactg taagctgctg ccgatccatc tggggctgat gtccgattac
    18121 tggctgcctc cgctttaccg tttcctgctg tgggccttcg gcgagacacc gggcgagcgc
    18181 ctgtggagtc tgcgcctgct cctgctcgat cagcccttga tgcccgatca tcagggcgcc
    18241 ggggagaggc aaccacgtta caggccacgc acctgtttag ggcgcatctg tctcgagcgt
    18301 gcgcattggc acctgcctcc cacctgcttg cccgctcgtc agacaggtga gacacacttt
    18361 gactactttc tgaaggtaca gcgctggcgc acgcagtatc agctaccggc gcgctgcttt
    18421 ctgcgtgtca atcccttcga tttccaggcc gccggagggc ctggtgaagg ccccgcctac
    18481 tcgcttggta aggagcgcaa gccggtctac attgactttg aaagctattt ctcgctcagt
    18541 ctcttcgagc acctgatcgc gaagggcagc ttcggcctgc tgctggagga ggccctgccg
    18601 ggggagaccg acctgctgcc cgctcgtgag ggtggctctg tctgcgaata tgtctttgaa
    18661 gttaacagcg aaggagcctg agagcatgga gcagcgcagc tggatcagcg cccatctctt
    18721 ttatcacggc gatctcagtg cactcctgaa gggctgcgta cagccgctgc tcactcgcct
    18781 ggagcagcgc ggtctgatcg cctcctcctt ctttgtgcgc tactggcagg ggggcccgca
    18841 tcttcgccta cgtctcttgc cacagacggc cagcgcctca gcgcagatta tggatgaggt
    18901 gcgccaggcc gctgcctgct atttccagca gcatccagct cccgactctc tggacgtggg
    18961 acgctacgag gagatcagtg gctacctcgc ctatatggag tatggccgcg ctgagtctgg
    19021 gccgctctac ccgaataaca gtctgcactt tctgccctat gtgccagaat atgagcacta
    19081 cggtggccag caggctatgc ccgccgtcga ggagcatttc ggggagtcga gcgccctcgc
    19141 tctggcgctg ctgacccagg acgccgatcg caggcagcgc acggcccata gcgtggcggc
    19201 gctgcttctg accgccgccc tggaagatcc gacgcgagcg gcaacggctc gagtgatcga
    19261 gcacttttac ttttcctggg agcgtatgcc tgccagcctg cgtactcgcc tgctggcccg
    19321 ttttgatcag cagtacgaag agcagcgcca gcgccttgag caactgagcg agcagctctt
    19381 gcgcctctct gctcagcagg agtctgatct cgacgactct gcaacgctgc tcatgcgctg
    19441 gctacgctcc attcgccggc tctaccgccg gctgcgggag ctggatcagg ccggtctgct
    19501 ggtctccccc caggtgccca caacgccggc cagaccggtc agcgcgccgt tgactattct
    19561 gctacgctgt gcccatatgc acaataatcg cctcggtctg ctgctcctcg aagaggctta
    19621 cgttctccat ctgctcaaac gtgcgctcag cgaaggcggt cagaccagcg gatctgattg
    19681 gcagcccgag ccgcttcccg gcaggcagct ctagagacag gagcaagcca tgtctagcag
    19741 tagcgttgct tattctgaag gcggggactg gcagagtgtc catgtctact attatgctga
    19801 gcagcagaac gatgccctgc tcctcgactg cattcagccg ctgtttgttc aggccaggcc
    19861 catcacgaca cggctcttct ttgtgcgtca ctggctgcgt ggtcctcacc tgcgcctgcg
    19921 cttttactgc tcgccgacgc agttcgctgt ggcgctcaag ccgctcatcg agtctatcgt
    19981 ggggagctat ctgcgccagc acccttccag tgcccatctg gatgaggagc agctgaaagg
    20041 cctctacgcc acgctggccc gccaggagaa ggaagccggg ccgttcttcc cgctctatcc
    20101 cgataactcg atccagtatc tgccctacga ccgtcgcctg cacgtccttg gctccgaggc
    20161 cctggcgagc ctgctggaag atttctacgt tgacaccaac gacctggcct ttgccatgct
    20221 ggcccaccgg cgtcagggtc attcgctact gaccctctgc ttcgacttga tgatcactgt
    20281 ggcccatcgg cagggccagc atatcgcccg tgggttcatc tcttaccgct ctcatgctga
    20341 gggctttatc atcgccagcg ccgaccccgc ccgcatgcgc accctcctgg aggatcgcta
    20401 tcagcagcag gccaaaacgc tggttgcccg gcttcgacag ctgctggcgg ctctggaccg
    20461 ggagcaagat acctttcctt tcactctggc ctggtcacgg ctgatgcagc gctatcaaga
    20521 acgcgctgct caactgatcg ccgccggcca gatcgatctg agcgcagcag gtctggagac
    20581 ggataacgga ggcggcccgc tcgtccgtgg gaatctggcc gccagcgcct tccatagtgc
    20641 cctggagcgt gatcagcagc acaagcaggc cctctacagc gatccctggt tccagagcta
    20701 tcgccttgtg ctgaacctgc tctatctgca cttcagtcgg ctgggtctgc gcccgatcga
    20761 tcgttttctg ctctgccatc tggccgccaa cgcagttgag gaggctttca agatcagcgc
    20821 cgttgacatg gtcagcgcct tcagcgaagg ggccttgtcg gggccaccgc cctggccagg
    20881 agaaagaggg aggcaacatc atgcaggagc ctgagcgcgc gctctccccg tatgagcagc
    20941 ggccacagga aacgctggcg ccagcgctgc agcgctatat ggcggaggca cagcactttc
    21001 cggagcgcga ggtggtcgac tggcagcatg cgccgctcaa atataaaatc tatcgcggct
    21061 gcccttgcct gcgccttgct tatctgacgc cgcccacctc agaagccggt gcggagcaag
    21121 gccgccagcc gtttgggggc gctcagtttg gccagatgct ggccgatatc tatggtctga
    21181 cgcgccagcg ctggacgggg gccgagagct ataacgccat cgccgccggg agcaccttgc
    21241 cgatcctcga tccgctcaag catccgttca aacaggatct gctgcgccct gtgccttccg
    21301 gcggaggtct ttatccctgt gaactctatg ccgttatcgg cccggcccag gccctgccag
    21361 ccggcgtcta tcactatgat cccgtccatc atgccctgga tgtaatccag gatgccgacg
    21421 cccgtcctga gcagagcggt cgcttcctgg agaggctgct ggaagcgctg ctagaaccgc
    21481 cagcctgtgc cgccgacttc gcgctggtcc tgagctgctt cttctggaag aacgccttca
    21541 aatatggcga atttgcctat cgtctccaag gtctcgacct ggggattgtg ttgggtcagt
    21601 cgctggcggt cggcagctat tacgggctga agagtagcgt tcattttcgc tttgtagacg
    21661 gtgctgtcaa tgccctgttg aacctggacg aggcttatga gagcgcctat gcggtcatcg
    21721 tcttcagcct tggggatacg ccccgcggtc caggcattgg ctggcagcgt tggcagaaag
    21781 cggctgcctc gccgtccagc gtgacagacg agcgggcgcg tctgcagccc ctcagcagcc
    21841 tgccgctctc agccgccctg catcgcgcct cgctgatcag gacctgcgcc cagggccagc
    21901 cactgacagg ccaggaccag gatgcggagg agagcttgcg gggagcgctt gcagggtctg
    21961 gtgtggcgct gagcgatgat atcgggctgg agctggccag aggtacaccg ctgcgccatt
    22021 cagcgcgcca ctactttcgg cccgggcgca tcagtgagca acagtgcgct cagttgctct
    22081 atgccgctgg ccgtggcctg cagagcgata tcgctcctgc tgcgtcttat ctgcctcgcc
    22141 tcttgctcta ttgtatcgtc gctggcgtgc agggactcga tcccggtatc tactgttaca
    22201 cgcccggtgc tcgccattgg cagcttgtca ggtcagggga taggcgtcta caattacagc
    22261 aaatagtagc tcataccgga tatcataatg tctaccacat caatctgcac gtttttccgg
    22321 ttggagagta cagcgaggga gtgcgccgct atgggccccg ctggtatcgc atccagaaca
    22381 tgctggcagg aagcgtcatt cagcgcctct atctggctgc cgcgctgctc ggtctgggtt
    22441 gtcataccag cctggcctac tcgattgaag gagtgaacaa tctgcttggc cttgagagag
    22501 gggcgacggc gctggctcag gtgctgatcg ctcccgagcg cctcgctggc cagtattatg
    22561 agatgccgct accggctgtt ctggccgcgg cattgccaga aggatagcgg agaatctgca
    22621 tgcatccaac cattgagcgt aaggaggtca gcgtcgtgag cgggaacagt gccgcgatca
    22681 tctcgataga gagcgtacac aaatcctatg ggagtcttaa ggccctcgaa ggggtctcct
    22741 tgtacattgg caacggcgaa tgctttggcc tgctcggccc caacggagcc gggaaaacca
    22801 ccctgctctc ctgtgtcgag ggactcatca gctttcagga ggggcggatc accgtcagtg
    22861 gctatgatgt cgcccgtcag ccgcgcaaag tgaaaagcct cctgggcgtg cagctccagg
    22921 atgaaacgct cttcaccgat ctgaaggcgg ttgaagccgt ccagttctat ggcgcactct
    22981 acaacacctt cccaacgcgg gccgaggccc tggcgctgct ggagcgcttt gacctggctg
    23041 agaagagcaa tgcccgcatc ggcacgctct ccggcggtca gcagaagcgt ctgacgctgg
    23101 cactggcgat ggtgcaccag ccctcgatca tcttgttgga cgagccgacc accgggcttg
    23161 atccccaggc gcgccatcat atctgggaca tcgtgcgccg gctacggagt gagggcaaga
    23221 ccatcatcct gacgacccat tatattgagg aggccgaggt tctctgtgac cgtgtgggga
    23281 tcatcgatca gggcaagatt ctggctctgg gcacgccgcg cgagctgatc gagcgcatgg
    23341 gcaatctctc aacggtgcgc gccagcctcc atctacccac cgagaagctg cagcaactgc
    23401 agacagcgga atttgtccac gccgtgagcg gagacgatgg cctgctcact gtgcagacat
    23461 ctgatccgca gcgcgtcctg gctctgctgg aggagatcgg ccaggagcta gggagccgtc
    23521 cgcaaaacgt ctccatccgt cagcccaacc tggaagatgt ctttctctcg ctgacgggcc
    23581 gcagcatcgg gccagcggac tagcagctga tcggcctggc cccttacttg aatctgactc
    23641 tgtccggcgt cgttcggctt ctccctttga gacaagaaag gaaacgccta tgcgtcgctt
    23701 cataactgaa tttcgttttt tcattatttt ggcttttcgc agtcgcactt tgcttttctt
    23761 tagcctgctc gtcccgacag gctcgctgct gctcttcggc ttcgtctttg gccagaatgt
    23821 cattcctctg ccgggtagtg gcggcgtctc ttactcggtt tggctgctgc cagggatcat
    23881 cgtgatgaat atgattgctt ccggcctcat ggggaactcc acggccatga tcacctggcg
    23941 tgagcggggt atcttcaggc gtattctggt gacgccaacg gcgccgtggg aggtgatgct
    24001 ggcgcgcgcc tgcactcagg tgctggtgat cgtcatccag accatcgtcg cgatcatcgt
    24061 tggcagcctg gtctttcatt tcacctttaa cccgctctat gccccgctga ccctgctgtt
    24121 catcattctc ggctctgccg tctttctgct gctggggcag gttattgcct ccttcacgga
    24181 tcgcgtggag attggcaata tcattagcca gggtctgtac attctgctga cctttctgac
    24241 gggtattctg ctacctctgc agattctgcc agatattgtt tccaagattg ccccttttac
    24301 gccctcctac atggtggccg agctgctgcg cagtgcgatg ctgcagggca acgctggcag
    24361 cgcgccgctc gccgatattg ttggctgttt gctatactgc gccgctgctc tgggtctgtc
    24421 ggcggcgttc ttccgcatgc tgcactgagt ggtgttcacg accggtaccg gtcatctcac
    24481 tcaaggtgag gggggctgca tgagctacac gatcctgcgc gacgtctgcc tggttgaggg
    24541 ggcgtcgcag gaaggcatca ggaagggatg cgatctctgg ctgcgaggag ggagcatcga
    24601 ggccattacc gatagccgcg ctcgcttgcc gctcagggga gaaggggaag agattccctg
    24661 ttctggcctc tactgcctgc ctggtctgat cgatatgcat acgcatgtta cctcgcccgg
    24721 cgaggagcgt atcgaggaga gcgatgattt tcgtcgtctg ctggccgagc acggacggca
    24781 ggctctgggg gccggggtga ccaccctgcg cgatctaggg ggctggccgg aggtgctgct
    24841 ccgtctgcgc gcgggggcgg cgcgcagtcc tttctttccc aatctcgttg tggctggtcc
    24901 cttcctcact gctcccggtg ggcatccgac cattggcctc tttcacgggc tgagcgcatt
    24961 gcggcgggcg gctacccgcg agctgagcga gccagagcag gcgcgcgcgg tggtcgacca
    25021 gctcgccgcc agtggcgtcg acttcatcaa ggtcgtctcc acggcctgtt tgatcgttcc
    25081 ccaggaggag gcgcaggtcc ccaagctgcg ccccgagatc tttgcggcca tcgtcgccgc
    25141 ggcccatgcc cacggcctga aggtcgttgc tcataccatg acggcggcgg atgtacgtga
    25201 ggcggtgcgg gtcggttgcg atggcatcga gcacggcatc gtttgcgacg ctgtcgaggc
    25261 ggcttgcgag ccggagttgc tcgaccagct gcgagagcgc cagatctgct acgtgccgac
    25321 gctggccgct attgagcaac tggcgcctcg cttcctggag caggcgatgc agaacgccag
    25381 acgcctcgcc gagcaggggg tgctcattgg cgtgggcagc gacgctggca atccgggcgt
    25441 gcccttcggg gccgggctgc tgcgggagtg cgagctgctc tttgcggctg gcattccgcc
    25501 agcacagatt atcgctggtg ccaccagctg cgctgcggaa cagctcgggc gtggcggaca
    25561 gctgggccgc ctgagtcccg gttatcaggc cgatcttgtg ctgctccggg ccaacccgct
    25621 ggagcacccc ggccatctcc ggcagataga ggccgtcttc aaggctggct gctgtgtcgc
    25681 tgcccgccct gcttctgttt ttcgtcgtca gcatccatca gcttcgtttc aggagtctgt
    25741 gtcgtgagcc aggaaaattt gcttccgctt tcttctctcc aacgccgtca gggccggttc
    25801 ggttttaacg cggtgagcgt ggctgagggg ctgtttgctc tgggggttct ggcgttgctg
    25861 atctctgtct ttctgccctg gcgctatagt gtgctcaatc gtcccggcga gcctgtgctg
    25921 gtgctcagcg gctggcagac tggtctgttg ggcggccagg gtctctgttt gctggctggc
    25981 gctgtgctgg tcctcttgct ggcactcagg cgctggctgg cgcctggtca gcgtgccctc
    26041 tgggagatcg tggcagccgt gctgctgggg gcaattaccg tggtgacctt caaagacgtg
    26101 ctcgatttct atagtgggtc gctggctctt gtgattaagc atagcgtgtt gggtgccggc
    26161 ttttatgggg ctatgctggg cctcgatctc ttgctgtttg cctgtttcct gctggtaagg
    26221 aggcggcagc gtcaagcgga gcctggccag cagtcagcgc gctgaggccg gggttgagat
    26281 ggctccgctg tctgtcagct tgcaccaggg ctactggcag gatagtcccc accctggcca
    26341 ggctcacggc agcggcgtct cttgctctgg ctctgctcag cgagcgctgg gtgagcggta
    26401 ctgttgctgg tcagggcaca gaccggaaag aggttggcgg ccaccgccag tcagtagcac
    26461 tggcggagtg tgaccgattt cacagtagtg agcaacgggc tgtgatactc tatactcagg
    26521 ttctggtgag aaaatctgag tgcgttaaaa cagtagcctc tcttctgttc gctcctgaaa
    26581 ggcagcttgt agtgcctatc ctgataccag ttcgtggctt tgagcctcac ttaaaaggaa
    26641 taggatttta ttcgtgaaaa agagtacaaa aattgttttc ctttttctgc tcgtgttgac
    26701 cttcctggca ggctgcagcg gttccccgcc aagttcttct acgggggggg ctgcggcttc
    26761 tccgtccgcc acaagtgcta cgccgcgtgc cagcgcgact gtgacagctg ccactccggt
    26821 ctcgacggcg cagaccgctt tcagggttac ctcagttcag atggctgtca gcccggcctc
    26881 gatcgccggc cagagctgcg gcacagagct gacagtgacc tatacggcta ccttccatgt
    26941 ggttcctgac cagggcactc atactgtgca atttgcgtat accacaaata acgggcgctc
    27001 gcagcagttc gccagcttac agttcttgcc gggacaggct acaaagacgt tctccttcag
    27061 ctggcatggg gcgctgccgc tggatcacac ggctcccggt cttggcgggg tccttgtcac
    27121 cagtcccaac cagctcatct cgacaccggt caagccagct ggtctgtgta ctccggcccc
    27181 cttccacgtg acgtcggtca ctatgagcgt taaccctggc acgattgccg gcctgcattg
    27241 tggcaccaat ctgaaggtga cctatacggc taccttccat attgctccgg ggagtttggg
    27301 cgggatcatc aagtttggct atactgtgga taacggacgc agcggcggcg acaacaccca
    27361 gacgctcgtc gttgggcctg gagccacgac gcaaacctat tcctttacct ggagcggggt
    27421 cttgccggct gatcatacct tccctgagcc aggcggagtg ctcgtctcca gtccgaacgt
    27481 cgtgcgttct ccactggttg ggccgagtgg ccagtgtagc tgaggagttg cacgggagat
    27541 agttccttct tgctctgaca gtccagctca tcgttcgctg gttgcctctt catggtggcc
    27601 agcgggcaga gcctttgttt ggaggatgga agcgggaagc ctcctttcct gcacaggcta
    27661 tctccggcga tgaggctgac aagcccgctg gataggcagg tttgccgaga gaacagctct
    27721 gggctgtgat gatcgagggc cacctctacc cctggctttc cgggagccag gagaggtggc
    27781 ctgtcttttg ggaaggtgtg ctgtgatgtg atgccactgt tggtcgggca tctgctcagc
    27841 ggatgttctc agggaggccg acgctaaggg tgcggcacag gcacgagccc ggggtggtgc
    27901 aggagcaggg tgggtgcgct gagaaggcag ccgttaacca gctgtggggg aagcttctga
    27961 ctgattggct gtggctggct tctctcccca gacggtgagc agggtccaga gggcacagaa
    28021 gtcctcctct tgcatctcgg cgacggcctg ctggtagagg gcagccagct cttcggctgt
    28081 cgctacgcct accttcacca ggaacggctg taccagctcc aacccgatga gatagtcctt
    28141 aaagacggga tagtgtccct cggttcccat tgaccactcg atagcgctgg cgcggagccg
    28201 cactcgctca aaaccagctt gccgcaacag ccgcggcagt actggcgtga tgccgatgtg
    28261 gcggccatcg ggcgagaagc tctggccagc gcgcttgagt gcttcggttc ccaaggcgct
    28321 gaagcgctcg aaggcgggac tgctggtgag cggtggctct gtttcgctgc agcgcaggat
    28381 gccgccgggc ttgagcaggc ggaagcattc ggcgagcagt cgcggccagg ccgctggtag
    28441 catgaagccg aagaggagcc gcccgttgat caagtcaaag gactggtcgg gggaaggcag
    28501 ggggtccatg acgttgccca cctgaaagtg gacgttctcc agcccgcgcg accaggcttg
    28561 cgcgttggca tactcaatga ctaaggggct gatgtcgatg ccgagaatct ccaccttggg
    28621 gaaacgaaag gccagctcta gggcccagcc gccagggcca caggccaggt cgaggacgcg
    28681 gcccctctcc ggcaggttga tcccctcctc tggcagcaga ccacccattg cttcggtgag
    28741 caaccgatcc tgctgcatca gacgtgctag ctcggcagct tgctcagaat cgataatata
    28801 ggtgtttctg gaggatgtcg aggatggcga tggctgaggc tcgacatggt gaattggggc
    28861 ggctgctgct tctcgttcgt tcatgaaggc tcctttctgc tcgctagtcg ttctgtcccc
    28921 tcagtggagg aagatcatgc tacagtgtct ttcactgctg cttctagtat aatgaatcaa
    28981 tgcgctcact gtctgcccct acctctgcct ctggaagagc tatctccacc aggtgtatcc
    29041 ccaaggcttc ttgttctgcg gtcggggatg cactacgggc cttggagctg gcagtgtagg
    29101 ctacgacctg tcctgtcctg tgggagtggt ggaaagcagg gactatcacg ggagtagggg
    29161 aagcggtaat gagaacgagt ggctgcgaag gttgacctga ttcgggaagt tgtagccata
    29221 cctcaagata gatatgatat atggtatcaa gaattgaaaa aatatttttt gctcctttga
    29281 taggtttatg cttgttgctt cgaggatctc ggctcccgac tttccacgca gcgatcctcg
    29341 aatggctttt gacgcgctct gagtggcaaa gtgcctggca tcattaccgc ttaagagcgg
    29401 tcactagtga ccgatttttt gggatcatcg aaaaaccttg acggaagccg ctccagatgc
    29461 tatcttaagg ggggtgccct cagaatcaga gaaagagccc gtttgggatt gaaactcaat
    29521 ccctgaacgg gcttctccca gctcgtaggc ccctcagaat cagagaaaga gcccgtttgg
    29581 gattgaaact tgtcgaattg cccagtgtca acaccggtac actactcaga atcagagaaa
    29641 gagcccgttt gggattgaaa ctggagggtg ggggggtggt tagttgtcga gcagttcctc
    29701 agaatcagag aaagagcccg tttgggattg aaacctgaag gagggggcat ttcatcgtct
    29761 ggccggcatt ttgctcagaa tcagagaaag agcccgtttg ggattgaaac ttctcaatca
    29821 gctgtcggta cttgagcacc tcttgactca gaatcagaga aagagcccgt ttgggattga
    29881 aacccctgcg gagacgccct gtctgctcgt agttgtgaac tcagaatcag agaaagagcc
    29941 cgtttgggat tgaaactttt ttttgcgcct gcccccccaa ggggggcagg aacctcagaa
    30001 tcagagaaag agcccgtttg ggattgaaac cgtatatgag gatggagtag cgtatatgag
    30061 gaaaactcag aatcagagaa agagcccgtt tgggattgaa actcgaccca ctgttgtccg
    30121 ggccggcaga gcacgaccct tctcagaatc agagaaagag cccgtttggg attgaaactg
    30181 catgccgtct atgacggcgt gcacgctctt ttttctcaga atcagagaaa gagcccgttt
    30241 gggattgaaa ccaggagcag aggatgaccc gcgcccccgc cgcaagagcc gctcagaatc
    30301 agagaaagag cccgtttggg attgaaacgc atggctggca gagcgacatg acatggtcag
    30361 atcggctcag aatcagagaa agagcccgtt tgggattgaa acaaactgtg tcaacagcca
    30421 gccccagcgg cgctcagaat cagagaagga gcccgttatt gagggcaaca caaggattct
    30481 caggctcaga aagaggaggc aggcccgtct gggtctgggg ctgagatcaa cagaaacaga
    30541 aagaggaagc tgcgtgccag attgaagagg ggaagcacca gcagagcaga gcagaccttg
    30601 aatagcgcgc acagactgag cacctcactc actcgtggcc tggcctcatt ctggcagctg
    30661 ctctgctcgt ctacggcctg catggatgta cggaagtgcc gttgattccc tgcatacctc
    30721 agctcggccc ggctggtcgc aaaggcccac tcgccgtgct catctgcacc ccatcggggt
    30781 cagctcctgc tccaggaagc ccaggggcat gagcagatta gccggaacca cgacgagcag
    30841 ctatttcagc tctcccccgg cctcaagaga ggtaatagtg accgtgctgc cggagctggt
    30901 cacctcgata agataataag gatctgctgg atcaaagcca gcactggata acctcagctt
    30961 gttacccata taagtttgac cgtcgaaggc ccaggcggac ccccagcctt tgagatgcgc
    31021 ttgtgcagca acacctgcag gtcgttgcac gacaatctct gatcctcccc cgctgatccg
    31081 tatgggaacc actccagagg gcacgggaag ctgtagcagg atttgactgc ctactcccct
    31141 gacctcgaaa gaagcaagat tgaggccgct caggtcggca aagacatctg atcccccgct
    31201 ctggacgacg atttgccacg gaatggagcc gttcagagta atctctgcct gacgctgatc
    31261 tcccgtcaaa agcaggaact gtcgaggata gcggatagtg actactccac cttggacggt
    31321 cacattggga accgctccct tgaaacgcgc ctggtagagt tcggccattt ctgagctcgt
    31381 ccgtaagacc agccggatgc cagcagagag aaaaaccagt cggccctgcg ggagatcatc
    31441 caggggagcg gagaaaatac ttctctcttc tggcaaggcc gtttcttgca gctggagcag
    31501 ctgctggcgc gaaagcgtgt tgctgcgctg gagaaaggct aagagaaagg caagttgttc
    31561 ctcattatag ctcgatatca cctcgtccca cgtctcctca agagcagcca gcatcgcgcg
    31621 aaccttgcgc agctcctcct tgcctgcggt gagccggaca atgaccctgc gaccatcgct
    31681 cttgtctcgc tcccgataca ccagcccaga tgcctccaga cggttgagca ccttggcaat
    31741 ggccccgctg atcattccca tcaattcggc gagctgacca gcagaaactt caccggccag
    31801 atcgagcagg tccagaacct ggatgtctgt gtcagccgcc aggcccgcct gggtcgctgc
    31861 tacacggaag aaggcagcgc caaaactgtt actcttcctc aattcacgct tgatggctgc
    31921 cagcatctcc gcgcggtttt cctgagtgtc acttgacacg gtctcttcct ctgtggtacc
    31981 ttctatttgt gtgactcagt cacttaaatg aatttttctt tagtgactag agaataaaaa
    32041 tggcggagtg agtggtgacc caatcagtaa atgagtatac cataggaagg tctcgcctgt
    32101 catggtcatg ctggagctgg aaaccaccct gcaggatgca ccgtcccaac cgtcttatcg
    32161 cggctggggg gctatcccgg ccctgactgg gcctggcgac tggaccacct gggtccggtg
    32221 cttgtctaaa gtgtgaaaag taatcaacct gacgtaggag gcatctgatg ccagacatgg
    32281 caattcaagt cagagatttg cacaaatcat accgacagct caaagtcctg caaggcgtcg
    32341 agttcgccgt cgagcagggc cgcatcttcg ccctgcttgg ccctaatgga gcggggaaga
    32401 cgacgctcat caagatcctc agcaccctcc tcaagccaga cagtggcaca gccctcgtca
    32461 atggctttga tgtgatcgcc caggctgccc gggtcaggca ctccatcagt ctcacgggcc
    32521 agtttgcggc tgtagatgag ctattgaccg gacgtgaaaa cctcattatg atcgcccaac
    32581 ttcgacacct caaacagccg cgtcggg
//
