LOCUS       NZ_MCIF01000002        20738 bp    DNA     linear   CON 09-NOV-2024
DEFINITION  Thermogemmatispora tikiterensis strain T81 A4R35_scaffold00002,
            whole genome shotgun sequence.
ACCESSION   NZ_MCIF01000002
VERSION     NZ_MCIF01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Thermogemmatispora tikiterensis
  ORGANISM  Thermogemmatispora tikiterensis
            Bacteria; Bacillati; Chloroflexota; Ktedonobacteria;
            Thermogemmatisporales; Thermogemmatisporaceae; Thermogemmatispora.
REFERENCE   1  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Analysis of Carbohydrate Active Enzymes in Thermogemmatispora T81
            Reveals Carbohydrate Degradation Ability
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5961682)
  AUTHORS   Tomazini,A., Lal,S., Stott,M., Henrissat,B., Polikarpov,I.,
            Sparling,R. and Levin,D.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-AUG-2016) Faculty of Agricultural and Food Sciences,
            University of Manitoba, 66 Chancellor's Circle, Winnipeg, Manitoba
            R3T 5V6, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2011
            Assembly Method                   :: Newbler v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 25.9x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003268475.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 03:19:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,660
            CDSs (total)                      :: 4,607
            Genes (coding)                    :: 4,541
            CDSs (with protein)               :: 4,541
            Genes (RNA)                       :: 53
            rRNAs                             :: 2, 1 (5S, 23S)
            complete rRNAs                    :: 2 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 66
            CDSs (without protein)            :: 66
            Pseudo Genes (ambiguous residues) :: 0 of 66
            Pseudo Genes (frameshifted)       :: 8 of 66
            Pseudo Genes (incomplete)         :: 56 of 66
            Pseudo Genes (internal stop)      :: 6 of 66
            Pseudo Genes (multiple problems)  :: 4 of 66
            CRISPR Arrays                     :: 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:11:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 136004
            Orig. end                         :: 156742
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MCIF01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20738
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20738
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20738
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10738](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10738)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            131..586
                     /locus_tag="A4R35_RS00540"
                     /old_locus_tag="A4R35_00515"
     CDS             131..586
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013382.5"
                     /locus_tag="A4R35_RS00540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_00515"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_223258126.1"
                     /transl_table=11
                     /translation="MCGPGGWAMEVAFHFPRVEIVGIDISQQVIEYAHAQARSRALENV
                     HFQLMNVMEPLAFPDASFAPINGRGLSGCMLPATWPRFLQECFRLLIPGGVIRLTEHNA
                     AFFPADENGYPNRGPGCQGPHGYASNRAQLVQGASAWLQHQLPAAAR"
     misc_feature    complement(746..762)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.96"
                     /tool="antismash"
     misc_feature    complement(1102..1111)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.04"
                     /tool="antismash"
     misc_feature    complement(1186..1200)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.87"
                     /tool="antismash"
     misc_feature    1387..1401
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.98"
                     /tool="antismash"
     misc_feature    complement(1397..1411)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.66"
                     /tool="antismash"
     gene            1526..2011
                     /locus_tag="A4R35_RS00550"
                     /old_locus_tag="A4R35_00525"
     CDS             1526..2011
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00525"
                     /product="hypothetical protein"
                     /protein_id="WP_112425524.1"
                     /transl_table=11
                     /translation="MTTPVFVLLVGQLLPAKTCTGWLRCASIEKRQTGNPWIEEQKATT
                     MQILQRLKLAVGGMDCPECCGHVHEAIVTVDPSRVDMEMLCQAVKRAGYDAQPVRQQQV
                     SGERGRAARHSAAKLARSLLTLYSLLFGAVLLLVIAGEWLACWNVSPISSPGTSAPV"
     misc_feature    complement(2268..2283)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     gene            2452..2913
                     /locus_tag="A4R35_RS00555"
                     /old_locus_tag="A4R35_00530"
     CDS             2452..2913
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00530"
                     /product="hypothetical protein"
                     /protein_id="WP_112425526.1"
                     /transl_table=11
                     /translation="MVLLILLVVKGAWLANAAVVVFWLVLEWRSWRNVGRLPLKLAPPV
                     PALLAVRQGGNSLLTSYHAAYPIQSYALDLVVVDRLVRCARRGGLFPRRLTSYRSFGQA
                     VLATCDGVVLACQDGLPDLPVGQMGPERPAGNHVVLQVSKQPAISPLPK"
     misc_feature    3099..3111
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.52"
                     /tool="antismash"
     gene            3322..3684
                     /locus_tag="A4R35_RS00560"
                     /old_locus_tag="A4R35_00535"
     CDS             3322..3684
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00535"
                     /product="hypothetical protein"
                     /protein_id="WP_112425528.1"
                     /transl_table=11
                     /translation="MSEDDWQPPLNRSARSDRPEGLSPSDQADVAPSSQSQQVSERSLW
                     LQRRAQVKEKQDQYAAGVCLADLIGLIVLFAFFVAFNGHLISSGAFMIAMVVDGALMAT
                     VHVIAYAMARRAEDIY"
     gene            complement(4189..4494)
                     /locus_tag="A4R35_RS00565"
                     /old_locus_tag="A4R35_00540"
     CDS             complement(4189..4494)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00540"
                     /product="hypothetical protein"
                     /protein_id="WP_112425530.1"
                     /transl_table=11
                     /translation="MIPRWLIWLPWDRLSSSAPTPPILSADLASMVTAYQQAGGASFTL
                     QALLIFMLLTKFESIAHHGARFLRGEIAADLVLSQLEKIRMIMLLAQESQKRDFAV"
     gene            4707..4997
                     /locus_tag="A4R35_RS00570"
                     /old_locus_tag="A4R35_00545"
     CDS             4707..4997
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00545"
                     /product="hypothetical protein"
                     /protein_id="WP_112425532.1"
                     /transl_table=11
                     /translation="MENGSLEQRFAAFEVKMNGQLTDIIGLLQQLVAEVRDQGHRLNAV
                     EIRMNTFENRMAGCEQRLSALEARLNEQQQSISLLSTFQRKMMQKMGIEYE"
     gene            complement(5599..5931)
                     /locus_tag="A4R35_RS00575"
                     /old_locus_tag="A4R35_00550"
     CDS             complement(5599..5931)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00550"
                     /product="hypothetical protein"
                     /protein_id="WP_112425534.1"
                     /transl_table=11
                     /translation="MPTQEERLAAVERAVMDINHNETILLGMAVKYEELLREIRAMLAQ
                     MVGHLGEHDRRFDAHDKRFDAHDKRFDAHDKRFDAHDKRFDEHDKRFDRLEALLMQVLA
                     RLPEPS"
     gene            complement(6216..6413)
                     /locus_tag="A4R35_RS24520"
                     /old_locus_tag="A4R35_00555"
     CDS             complement(6216..6413)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS24520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00555"
                     /product="hypothetical protein"
                     /protein_id="WP_146747055.1"
                     /transl_table=11
                     /translation="MSDQVVLFTTDTGMDATLLSHVRPYSARIYRFSYESELGATSVSC
                     EEGGNAPPLPERRKVPGRAY"
     gene            complement(6427..6810)
                     /locus_tag="A4R35_RS00585"
                     /old_locus_tag="A4R35_00560"
     CDS             complement(6427..6810)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00560"
                     /product="hypothetical protein"
                     /protein_id="WP_146747056.1"
                     /transl_table=11
                     /translation="MRNHKKQRNSKYSSNRTRMVLSTYRDALTRQKLRELEKKLIQYFA
                     QLCHKEDLLTQVLIDPETFAVQFRDVHGRLLSLASFSAGERQLYALALLQALRAIGQRR
                     LSLVMDTPLALLDEEYRQRFLRE"
     misc_feature    complement(6804..6818)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.22"
                     /tool="antismash"
     gene            complement(7517..8254)
                     /locus_tag="A4R35_RS00595"
                     /old_locus_tag="A4R35_00570"
     CDS             complement(7517..8254)
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006302 - double-strand break repair
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024867.5"
                     /locus_tag="A4R35_RS00595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_00570"
                     /product="AAA family ATPase"
                     /protein_id="WP_146747057.1"
                     /transl_table=11
                     /translation="MLLLECSVEHSGVFAGKHRFDLRPSLGEDGSQRPLIVMIGQNGSG
                     KTALFQALLSALYGAGSLQGSLSTHSLLSRMHRPCSGPAAEQSAVSLSFQYVHSGHLVE
                     IQVERRWRTRHGTVEEDLSLLHDGKPLEIDPAGYPVWLYEFLSPGHGHLCGEQFDALIA
                     PRHQSKTLEGILSRLLGLDLTQRLDGDVGQLLTRQGSSEKTSSLYKRVLELRGEADSLQ
                     WQLSQLEQDLEHLQAALADHELP"
     gene            complement(8371..8532)
                     /locus_tag="A4R35_RS24070"
     CDS             complement(8371..8532)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042543.3"
                     /locus_tag="A4R35_RS24070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA modification system-associated small protein"
                     /protein_id="WP_189361178.1"
                     /transl_table=11
                     /translation="MDPRSCDDDPVFDATQKELLAGICKEHDLPFEMVTKLLEAEKQSI
                     DITKRAAS"
     misc_feature    complement(9279..9295)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            complement(9496..9840)
                     /locus_tag="A4R35_RS00605"
                     /old_locus_tag="A4R35_00580"
     CDS             complement(9496..9840)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00580"
                     /product="hypothetical protein"
                     /protein_id="WP_112425545.1"
                     /transl_table=11
                     /translation="MSRNAPTGTATRQTFAETLISNIVTGISIGAMLALLIAILGLLGI
                     FIYGVTYPQQEVHLKLFSLEIFDFTSQGASFLFRMHAPGALMALGLLTLLGACVFWVIR
                     AARRFQPRSS"
     gene            complement(10001..10738)
                     /locus_tag="A4R35_RS00610"
                     /old_locus_tag="A4R35_00585"
     CDS             complement(10001..10738)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="A4R35_RS00610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_00585"
                     /product="PqqD family protein"
                     /protein_id="WP_223258480.1"
                     /sec_met_domain="PF05402 (E-value: 5.9e-09, bitscore: 34.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 2e-07, bitscore: 28.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPVLPAGVAVHTASLEDRALRQHYPLNSTAREFLTLIDGRRSFA
                     SIAEQLAERYRQPREVLLKDLGQLSLELYHHGLLNWHETWHQRSIRWLLALRTRTLPAL
                     YTWRSDPPLTTNPLLLLGWLYLEVWRAWLPVLSAGLLGAAGAGALLAVLPLLTLAYLAL
                     ALCLTLSICLHEGGHLIVLHHYCGAGSGFLLRTGPLLRLIRPPWRAPRRRSRSMRPARC
                     FPAASGCLPWSGTCSTPGRWTGY"
     aSDomain        complement(10502..10666)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A4R35_RS00610_PqqD_RRE.1"
                     /evalue="1.20E-09"
                     /identifier="RREFam006.1"
                     /label="A4R35_RS00610"
                     /locus_tag="A4R35_RS00610"
                     /protein_end="79"
                     /protein_start="24"
                     /score="28.7"
                     /tool="antismash"
                     /translation="YPLNSTAREFLTLIDGRRSFASIAEQLAERYRQPREVLLKDLGQL
                     SLELYHHGLL"
     gene            complement(10740..10946)
                     /locus_tag="A4R35_RS00615"
                     /old_locus_tag="A4R35_00590"
     CDS             complement(10740..10946)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00590"
                     /product="hypothetical protein"
                     /protein_id="WP_146747058.1"
                     /transl_table=11
                     /translation="MLMVSGVMVTLGPPLYVLFQQAQEALARLPGGMAAQMLVQTAAAL
                     LIMGMLYLGIHQLADVKMEKDRD"
     gene            complement(10925..11821)
                     /locus_tag="A4R35_RS00620"
                     /old_locus_tag="A4R35_00595"
     CDS             complement(10925..11821)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00595"
                     /product="hypothetical protein"
                     /protein_id="WP_112425551.1"
                     /transl_table=11
                     /translation="MGLATPLQLLLAVFLGLPAYNGITLAFHQAVLYGTTRIFGAERVD
                     LRSTALRVSMALGMVLFTLPLILGAQALLARQPGWLILTPAYWILLILQSDLLRAIAGL
                     GLLSALGLLGVVIYAFCVERCERLAVGTRGQWVPLRRLSFPSSLFMSSYLYELKGIARD
                     QQLVVGLVMVVAGWLVATVAVFWTRASNPLLSYGLLELALDLITFLLCAIAQMSWGRDS
                     RAYHVLASTPLDVHLLLDGKLSANLVVIVGGWVLLIGVLTWAGNNPLLLLQRLPLLCTG
                     CFLTRPKTRSRCSWCRG"
     gene            complement(11812..12243)
                     /locus_tag="A4R35_RS00625"
                     /old_locus_tag="A4R35_00600"
     CDS             complement(11812..12243)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00600"
                     /product="hypothetical protein"
                     /protein_id="WP_112425553.1"
                     /transl_table=11
                     /translation="MFWQISRLVILIWRNRLRQLFRRMPALWLVVLLAVISYCGGAYLS
                     YDFFYKITQFIASSSSTFLQLRTIIVTALFSAFSLTAFTLVSFALLFTPEETTLKRILA
                     PLPISPMQQRLGLLLPGFILLLPRTCSGCLHCWSSYRWA"
     gene            complement(12224..12844)
                     /locus_tag="A4R35_RS00630"
                     /old_locus_tag="A4R35_00605"
     CDS             complement(12224..12844)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="A4R35_RS00630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_00605"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_112425555.1"
                     /transl_table=11
                     /translation="MLVGLFPPTAGSIVLDGEETQSETPQMKHVFGFVPDSQEVIPHLT
                     GWEYLQFIQRIYGLSAEQWSLANEYLALLHMEAKAQDLLETYSHGQRKKVQLIAALQHQ
                     PELLLLDEPFSGLDPEMIALVKRLLRKLRERGVGILISTHDLLMVGELCDHVIFLNQGG
                     VVATGEPEQLLTCYGAANLEEAFLKALGLEEQEEALERVLADF"
     gene            complement(12763..12981)
                     /locus_tag="A4R35_RS25150"
     CDS             complement(12763..12981)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="A4R35_RS25150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_112425557.1"
                     /transl_table=11
                     /translation="MEVKRLTKSFGTFTAVDQVSFAIRPGSIVGLLGSNGAGKTTLLSM
                     LCWWDSFLPRLAASSWTARRHRARPRR"
     misc_feature    complement(13010..13027)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     misc_feature    complement(13054..13074)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 30.8"
                     /tool="antismash"
     gene            complement(13167..13394)
                     /locus_tag="A4R35_RS00640"
                     /old_locus_tag="A4R35_00610"
     CDS             complement(13167..13394)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00610"
                     /product="hypothetical protein"
                     /protein_id="WP_112425559.1"
                     /transl_table=11
                     /translation="MHSQHLTTYVAPVVLLEKREQRASPLAWYVVPLLILLGLAADIVL
                     AVAIWCVIHGQSVVVTWHINWSGTVTIACK"
     gene            complement(13416..13646)
                     /locus_tag="A4R35_RS00645"
                     /old_locus_tag="A4R35_00615"
     CDS             complement(13416..13646)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00615"
                     /product="hypothetical protein"
                     /protein_id="WP_112425561.1"
                     /transl_table=11
                     /translation="MQQPVFSCAASRPLVALSTRQTQETPIVWWVVALIVLLVLAAALI
                     VAMGIWCSLHGGGEVISWQVHWPFVTIGCSK"
     gene            complement(13668..13796)
                     /locus_tag="A4R35_RS24895"
     CDS             complement(13668..13796)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS24895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_262982307.1"
                     /transl_table=11
                     /translation="MLLAIAAVLALAVILWCAFHGGGVVVRWSISWDGYVTIGCSK"
     misc_feature    complement(13992..14006)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.28"
                     /tool="antismash"
     misc_feature    14332..14346
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.5"
                     /tool="antismash"
     misc_feature    complement(14572..14585)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.13"
                     /tool="antismash"
     misc_feature    complement(14573..14586)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.98"
                     /tool="antismash"
     misc_feature    complement(14574..14587)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.13"
                     /tool="antismash"
     misc_feature    complement(14606..14622)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.17"
                     /tool="antismash"
     misc_feature    14607..14616
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    complement(14609..14622)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.44"
                     /tool="antismash"
     misc_feature    14610..14623
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 20.32"
                     /tool="antismash"
     misc_feature    14611..14624
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    complement(14612..14625)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.35"
                     /tool="antismash"
     misc_feature    14612..14626
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.56"
                     /tool="antismash"
     misc_feature    complement(14617..14626)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    14913..14929
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.86"
                     /tool="antismash"
     gene            complement(14924..15970)
                     /locus_tag="A4R35_RS00650"
                     /old_locus_tag="A4R35_00620"
     CDS             complement(14924..15970)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00620"
                     /product="hypothetical protein"
                     /protein_id="WP_146747059.1"
                     /transl_table=11
                     /translation="MMQSRLAPLLTEGYPSIRIRWHAIITVMKAQLLLVRRRVLTLVVL
                     ALLGGGFLLATGFHLVLYVFATLPVSAQACPTASTSAQQVSQAPPCVSETPQQQAEQKL
                     LRQEVLREQKTTLTFPMSLSLGGDTLLSLGVLLLCIFVAIFVGSDYQAGTQHLVFLRGV
                     PLTRLVCAQSVMLLLILVIVSAALLMAGALLGCVIGPLLGGKLSPLSLQGWGELALYWL
                     GICVSLWLYALLSVLFTTLGRSIGAGIAGSIGYLFIQGLLLPPLTSMLSALPDSGFTAL
                     LRHLPALFLGPACHTLLEALASRPLPLVASAVPSSASTALAGAVLLCYGLISGGVSLLL
                     VHKRDVAL"
     gene            complement(15993..17051)
                     /locus_tag="A4R35_RS00655"
                     /old_locus_tag="A4R35_00625"
     CDS             complement(15993..17051)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011955873.1"
                     /locus_tag="A4R35_RS00655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="A4R35_00625"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_112425565.1"
                     /transl_table=11
                     /translation="MQHVASTPSGKDAPIVRLERVTRRFQQQIAVENFSLEIAQPGEIV
                     GLLGPNGAGKTTVLRLLLGMLTPTSGSVALFGVPMTSAVRRGEALRRVGALIEAPTFYP
                     YLSGRDNLRVVSLLAGLPEDRETEQRISQLLERLALPVEGPVAFKQYSLGMKQRLGIAA
                     ALLTEPELLVLDEPTNGLDPIGIVHLRELLRSLAQQGTTILLSSHLLHEVQQLCTRVVL
                     LKRGQVLIQGEVSRLLQTQGVIEVVYETPEALDAAEALLQRTAQEQPAWIRQVRRAGSA
                     ASVSSAEARVADPCVLQIQAPITSSTEICALLARHALYPAEIRRRSISLEQFFLDQASE
                     PAPTLSQAQRAL"
     gene            complement(17210..17548)
                     /locus_tag="A4R35_RS00660"
                     /old_locus_tag="A4R35_00630"
     CDS             complement(17210..17548)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00630"
                     /product="hypothetical protein"
                     /protein_id="WP_112425567.1"
                     /transl_table=11
                     /translation="MKRQWTIVLLLVICTTVIVLQLSGGFAESMQAIKHAMPGTISVPG
                     PRALIIDVLSFVAWVWGLVLTARTRRWRWLVLILVTGYIGGYLYSLVTLFRQVRGKSDE
                     HQPALTHS"
     gene            complement(17545..17919)
                     /locus_tag="A4R35_RS00665"
                     /old_locus_tag="A4R35_00635"
     CDS             complement(17545..17919)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00635"
                     /product="hypothetical protein"
                     /protein_id="WP_112425569.1"
                     /transl_table=11
                     /translation="MKQSTENRMLVVRRYWVRSGEPPLGYATHRYYPLIGLIGTTLLSA
                     LVVTFLIMRAETLVVLSVAVLVTFSVASMLLIRRYSGWYEVDASGNPLTFVSRSPLPGI
                     TVRNSISRKQFLEQGGIPGA"
     misc_feature    18084..18101
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.27"
                     /tool="antismash"
     gene            18351..18638
                     /locus_tag="A4R35_RS00670"
                     /old_locus_tag="A4R35_00640"
     CDS             18351..18638
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00640"
                     /product="hypothetical protein"
                     /protein_id="WP_112425571.1"
                     /transl_table=11
                     /translation="MMHTLTRVRLQIATKVTLLSSLIMAMVVSAMALPRGLGFLVSQFG
                     LSWQDALAIISILLTEGSAGIAAFAPWLLPFVGTLDGLILFIGVSAAAGW"
     gene            18691..18969
                     /locus_tag="A4R35_RS00675"
                     /old_locus_tag="A4R35_00645"
     CDS             18691..18969
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00645"
                     /product="hypothetical protein"
                     /protein_id="WP_112425573.1"
                     /transl_table=11
                     /translation="MQQTLARVSAKYAPTAVSLLSSAALLLTQGRLLLGWLVGQFGLSE
                     AVAALIVSIITTDGIWAAVALYPFLAPFVGTVEGLVFLFGTSVLVGW"
     gene            19031..20518
                     /locus_tag="A4R35_RS00680"
                     /old_locus_tag="A4R35_00650"
     CDS             19031..20518
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A4R35_RS00680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="A4R35_00650"
                     /product="hypothetical protein"
                     /protein_id="WP_112425575.1"
                     /transl_table=11
                     /translation="MLYSLGDLRAQGLLQQRRWWHRGLSILAGLICFVTLYRSAAAALA
                     HPFVAAATLPLVLTVCAFLLLVVNALAVGTLSETSGLEEVRALCSLPVTVADVVWIRLV
                     VGLLRSELVALIFFLPVCLATIVHLGWAPWPILASLTMLVAFPLLPAVLGVALNLSETR
                     PRLVVWFSALTSSLAVGVFLSQQVPLLPGPLALLGAVLSLPVRGVLAQAAPGETLLFAG
                     AWTLLAAAAGWVLMHQVSVSRERQVRERRSLAVSLLRTWLSAAGAATGRWGALLSLSGL
                     ALARLPAFLLATCTLALALWLSIAPRLLPTHTLGSPRLTALITALSLLLQSVVALVVCL
                     GPLLTALLGEAREHRVQQPYPIAARLHAAAVYLTFLGLAVPLVVALALLAGLLSHSVLL
                     YWFGAYLLSALPGGGALLLAMVLGRRPWIRLFAWGAGWVLVLLARVVALAAGVALLRVD
                     PLLLGLLSGLLVDVLLCLLCWRGLMVRQYRRFLEEDL"
ORIGIN
        1 ctgggaatgt ggccgaattg gcgcgcctgg tgcaacagga ccggctgctc accgggggca
       61 tgggcggtct cttccccgag tttcccgaca ggccgcccat gccgaagggc gcgcgcgtgc
      121 ttgatctggc ttgtgcggtc caggtggctg ggcgatggag gtggctttcc actttcccag
      181 ggtcgagatc gtcggcattg acatcagcca gcaggtcatc gaatacgcgc acgcgcaagc
      241 ccggtcgcgc gccctcgaga acgtccactt ccagctgatg aacgtgatgg agccgctggc
      301 ctttcccgat gcctcttttg cgccgatcaa cggacgaggc ttgagcggtt gcatgctacc
      361 ggcgacttgg cccaggtttc ttcaggagtg cttccgcctg ctcatccccg gcggcgtcat
      421 ccgcctgaca gagcacaacg ccgctttctt tccggcggac gaaaatggct atcccaatcg
      481 ggggcctggc tgtcagggac cgcatgggta tgcgagcaat agagcgcaac ttgttcaagg
      541 ggcgtctgca tggctgcagc accagctacc tgcagccgcc cgctgatctc tcttgccagg
      601 ccagcgttgt cagtagccgg cagcgccacc ggcccggaag gcccgcgccg atcagcgagc
      661 atcagagcct tgagccggaa gggatcgtga atgtcttgcc caggcgagga acgatggcag
      721 ctgacaaaga ccatcggacc cggtattgca ccacgttcgc agaagcagcc ggctgggcag
      781 cgcagtcagc caggaaaagg gtgatcatga gcagcacact aagcggcggt ttggctgccg
      841 ctttctttca gcgcctgcgg atatttcgag cgaagaactc cagcatttga gaccgcttag
      901 caggatcttt cacgatctct tccagcgtag tcacttcctt tgcggaggtt gccgacgaca
      961 taatccattg acctgtacgc gtccacacat ctacgaaaac gttgccatcg atgaggacac
     1021 tgccattggg gagacaacgg atggggacca gggcaggatg tcgatcttgc acaagaggga
     1081 accgcagtcg catctcatcc atcaaaaatt gcaataccgc ctgggatggt tctttctgag
     1141 acgatgagtc gtgagtcatc agaaaatcac cgccttcgct gcatcaatgg tcagaatatc
     1201 accttttcca cagcgcatca acctggcctt cgctggaggc ggccaggctc aatagcatgc
     1261 ctacctctct ttagggagct tctgtctcca cctcctccag gagattctcg cgtccctggt
     1321 tccgggcaaa atccttcagc tccatccagc acgacttggc tattttgata cgcttttttt
     1381 actcacattt tacataaatt ttgtgaatag ctctaggaat atgtgctgct tccttcacta
     1441 ttctcgctcc ataaagggta tcgtttgctc cagtgcgctc tgacgacgga ttccctcatc
     1501 gagaggaaat gtgagcagtt tcttcatgac tactccggtt ttcgttctac tggttggcca
     1561 gctgctgcca gcaaagactt gcactggctg gctgcgctgt gcttctatag agaaaagaca
     1621 aacgggtaac ccctggattg aagagcagaa agcaacaacg atgcagatct tgcagcgctt
     1681 aaagctcgcc gttggcggca tggactgccc cgaatgctgt ggccatgtgc acgaggccat
     1741 cgtgaccgtc gacccctctc gggtggacat ggagatgctc tgccaggcgg tgaaacgggc
     1801 tggctacgat gcgcaaccgg tcaggcagca gcaggtatct ggcgagcgcg gacgtgctgc
     1861 caggcattcg gcagcgaagc tggcgcgctc actcctgact ctctacagtc tcctctttgg
     1921 tgccgtgctc ctgctggtga tcgcaggcga atggctggcc tgctggaacg tctcaccgat
     1981 ttcgtcccct ggtacctcgg cgccggtttg accgcgctgg ccgcggcgcc catcttctgg
     2041 gacgtcctgc aggcggcaag acgccggcgt attatcttgc acaccctgat gtcgcctggg
     2101 gtaccagctg cgctggcagt acttgttgtt gctcgacctg ggatcctggc caactcaccc
     2161 cgcctcttgc ggttccgtct ctcatcccca agaaaggaag gagagcaaag ctgcgaatga
     2221 gagcaaagat aggaagggcc cccgcaaggc tggccaggtt tttggtgtac cgcccaggtg
     2281 tacgtctggt ttccgtgtgg ttgataaaag ggatctgccg cctgtcttgc tcatcttgat
     2341 gagctatgat caaggggcag atcttatttt cagcgcactg ctcctggccc tgctactctt
     2401 ttactttacc tgccctggga catactctgt gctacctgaa aacatcttat aatggttttg
     2461 ctgatattgc tcgtagtgaa aggcgcctgg ctggccaatg ccgccgtcgt cgtcttctgg
     2521 ctcgtgctcg aatggcgcag ttggcgcaat gtcgggcgac tgcccttgaa gctggccccc
     2581 cctgtgcctg ctttgcttgc cgtcaggcag ggaggcaact cactgctcac cagctaccac
     2641 gctgcctatc ctatccaatc ctacgccctc gacctggtcg tcgtcgaccg gctcgtccgg
     2701 tgcgcccgca gaggaggcct ctttccgcga cgcctgacga gctaccgcag ctttggtcaa
     2761 gctgtgctgg ccacttgcga tggcgtcgtc cttgcctgcc aggacggtct gcccgatctg
     2821 cccgttggtc agatgggtcc cgagcggcct gctgggaatc acgttgtcct ccaggtctca
     2881 aagcagccag cgatcagccc tctgccgaag taggctgcgg cagccaccgc tggcgctgtc
     2941 cctatcccgc cggtgccgcc tctaccggct tctaaggcag cgggctgggc cgctgcgagt
     3001 ctacctgttc cctcgttgca ggcggcccgg cccctgtcga tctggagctg gtcgtgatga
     3061 ttcgacgggc gtatgccgaa agattgacag ggcagaagat gcaatataca atggaggtag
     3121 tcttatctgg gtggcgggcg tgaagccacg caagaatgac gtgccaggac actctgaaag
     3181 cggcatgggg gggccggtct ggggcctctg gcgctgctca gatagctcag ctattccgca
     3241 gatcttcggg ccagagctgc tctctctggg aagctggagc agcttgtagg cgttttctcc
     3301 gagcaccgca ggtatgacat catgagtgag gacgactggc aacctccact caatcgctct
     3361 gccaggagtg atagaccgga ggggctttct ccatctgatc aggccgatgt ggctccatcc
     3421 tcgcaaagcc agcaggtgag tgaaagatca ttatggctcc agcgaagggc gcaggtcaag
     3481 gagaagcagg accaatatgc cgcaggcgtc tgcctggctg atctcattgg gcttattgtt
     3541 ctcttcgcct tttttgtggc cttcaatggt catctgataa gttcgggagc ctttatgatc
     3601 gctatggtgg tagatggggc cctgatggca acggttcacg tgatcgccta tgcgatggct
     3661 agaagagctg aagatatcta ttgatagttc tattgcagaa agtctggccg cagtccgaag
     3721 ggggggtgtc ccgcctgcgg tttggcatag gctgccacac ccaactgagg actttgccgg
     3781 aggtcttatt gacgcgccgg gtatcgattg ttgtggtaag atgccttagg cccttttccc
     3841 cgatgacgtt cgcggaagct ttcatcccat ggccggccca gtcgggcaga tatcatgaag
     3901 ggtatgccag cggaccctgc cgtttcggga atccagtgca tatacgccac cctggaccag
     3961 actcacgcac tggaggagcc gctgagcaag cgcgagctgg agatgctgag cctgatggcc
     4021 gatcgctcgc accgcggtcc acgcagtcga atcgggagcc ggatagcggc gtatatgggc
     4081 agttgccagc ccgtccgggg cgctgctttc acagaggccg ctccagcgcc agcagtgccc
     4141 tgcagctgtg gcttctccct tcccaggaag ccgctagcga ctgtcctctc agacagcaaa
     4201 atctctcttt tgagactcct gtgccagaag catgatcata cggatcttct ccagttgcga
     4261 gagcaccagg tctgcggcga tctcaccacg cagaaagcgc gcgccgtggt gagcaatact
     4321 ttcaaatttg gtcaggagca tgaagatcaa gagcgcctgc agggtgaaac tggctccccc
     4381 cgcctgctga taggccgtca ccatcgaggc cagatcggcc gagaggatcg gcggagtggg
     4441 cgcggaagac gatagtctgt cccacggtag ccagatcagc cagcggggta tcatagcgac
     4501 aacctgtggt aatgatgcca ggccatctgg ccctcagccg gcttcaccag ccattcgagg
     4561 atcgctgcgt ggaatgtcgg gagccgagat cctcgaacgg agcggcagga gcggcagcag
     4621 gaggggccgc gtcggaaacg gttgacggcg gcggagcgag atggtatggg agaggcgaca
     4681 ggttctgatg tgcccgggat ggcacgatgg agaacggatc actggagcag cgctttgcgg
     4741 cgttcgaagt gaaaatgaac gggcagctca cggacatcat cggtctgttg cagcagttgg
     4801 tggccgaggt gcgggatcag ggccaccgac tgaatgcggt ggagatccgt atgaatacgt
     4861 ttgagaaccg tatggccggc tgcgagcagc ggctcagtgc gctggaggcg cggctgaacg
     4921 agcagcagca gagcattagc ctgctcagca ccttccagcg caagatgatg cagaagatgg
     4981 gaattgaata tgagtagggg cctggtcctg gcctgctgag ggggagagcc agctcttgat
     5041 cgcggcgctg atctggcgcc tttttgttag gtttcgtgtt ccaatgggag gctgtccagg
     5101 tcctgtgtcc aggtcctgtc agtgtgccgc ctccagccca gggttcaacc gtgtccgtcc
     5161 catccaggga cagggccctg ggctgccggg gtccctccgg cagcgaacgg ggagggaacg
     5221 agtccccgtt gctctgacgg tgctctgttt agaccgcgct gtgcgcgttg tcttgggaga
     5281 gcgggatgcg ttccctggca tcccttgaca actggaacga cgacccccag acctggcggg
     5341 agcggtgctc aatcagcgca gggcagggca gaatgcggcg atccgtctca gtgtgtgctg
     5401 cctccaggcg agtcagggga aacgccgacg gcaggacctt cccttcctgg agtcacagca
     5461 ccttcgtaac actgcgagca tagcctgcca cccagggaat cacctgggag cgatctggga
     5521 acgaggcagg aagcaaaggg gaatgtcggg agaacggtgg tccaggcgag aagagggacc
     5581 aggtgtttcc gcctgtgctc acgatggctc aggaaggcgg gcgagaacct gcatcagcag
     5641 agcctccagc cgatcgaacc gtttatcatg ctcatcgaac cgcttgtcat gggcatcgaa
     5701 ccgtttatca tgggcatcga accgtttatc atgggcatcg aaccgtttat catgggcatc
     5761 aaagcgccga tcgtgctccc ctaaatgtcc caccatctga gccagcatcg cgcggatctc
     5821 ccgcagcagc tcttcatact tcactgccat gccgagcagg atcgtctcat tgtggttgat
     5881 atccatgaca gcgcgctcga ctgctgccag cctctcttcc tgagtaggca tagactttct
     5941 cctcatgccg atcgcttccc aggtaccatc tccatccctc atcgggcgag aggggcattc
     6001 tgacggtact tcctctagta tagcatctgg agcgagtctg tcaagcctgt tcgatgctct
     6061 cgacaaaaac tgggcagcgg tggccgcctg tgtagggtca tgccggccgg catgaccccc
     6121 atctcctgga caacagagca gatggagggc caggccacgt tcgggctttc agctggcgca
     6181 agcgcaggtc aacttcctgg ctgatggaga tgcggttaat aggcacggcc tggcaccttc
     6241 cttctctcgg gtaggggagg cgcgttgccc ccttcctcac aggagaccga tgttgcaccg
     6301 agctctgact cataactgaa ccgatagatg cgcgcgctgt acggcctgac atggctcagc
     6361 agcgtcgcat ccatcccggt atccgtcgtg aagagcacga cctgatcgct catcacagga
     6421 agatactcac tcacggagga accgctgtcg atattcctcg tccagtagcg ccagaggagt
     6481 atccatcacc agcgatagcc gtctttgacc aatggcgcgc agggcctgga ggagagccag
     6541 agcgtagagc tgacgctcgc cagccgaaaa gctcgccagg ctcagcaagc gaccatgaac
     6601 gtcccggaat tgcacggcaa aggtctcagg atcgatcagg acctgggtca gcagatcctc
     6661 cttatggcag agctgagcga agtactggat gagcttcttc tccagctcac gcagcttctg
     6721 ccgggtgaga gcgtctctgt aggtgctcag gaccatgcgg gtacggttcg acgagtactt
     6781 gctgtttcgc tgctttttgt gatttctcat actgagagat ggtctctttg atctctcgga
     6841 tctttgcttc cagctgaaag cggcgagatc cgatctgctc actgagttta ttggcacgct
     6901 tgcggttctc gctgatggcc tgttggagtt cggccatccg ctgatacatc ggctccagga
     6961 cggtttcgtc cggtgcgcgc cccaggtctt tctcgacgcg ctggagctcc ctgcgcagct
     7021 ggttgctatg cgcctgaacc tccttgggga tgaccagcag gatcgtatgg atccactggc
     7081 gcggcttctt ccgatcgggg tccgccaggt ggtggagcag cgcaggcggg tggtgtggct
     7141 tgcgcgcctt gctttgaact ggtcagccag gccttgagac gctcgatcaa tcgctggcgt
     7201 cccgcagcag aaagctccag accctcccag atctcggctc ctgcaagcgc ctgctccagc
     7261 atggcgatcc tctccaccca gagggcgcca gcgatctgct cacgttggat ctccacctcc
     7321 ctgttcaaac tcctgctcag ctcgagacag cactcagaca ccagggtaaa aaggagcagc
     7381 tcggcgcaga gctctcgcaa ggccccagca tgcagctcca tctgcctggt gatctctgat
     7441 tggggctgct ggagggcaga tcgctgagcg acatacttct tcccgccctc tgcgacaaga
     7501 agacgctcct gctccttcaa ggcagctcat gatcggcaag agctgcttgc aagtgctcca
     7561 gatcttgctc aagctgtgag agttgccatt ggaggctatc cgcctcgcca cggagctcca
     7621 ggaccctctt atagaggctg ctggtctttt ccgagctgcc ctgacgggtg agcagctggc
     7681 ccacgtcgcc atccaatcgt tgggtgaggt ccaggcccag aagacgggag aggatgccct
     7741 ccagcgtctt gctctggtgt ctgggggcga tcagggcatc gaactgctcg ccgcagaggt
     7801 ggccgtggcc cggcgataga aactcgtaca gccagacggg atacccggca ggatcgatct
     7861 ccagaggctt gccatcatgc aagagggaaa ggtcctcctc caccgtgcca tgtcgtgtac
     7921 gccagcggcg ctcgacctga atctcgacga ggtgtcctga atgaacatac tgaaagctca
     7981 ggctaacggc gctctgctca gctgctggcc cgctgcaggg ccggtgcatg cggctaagga
     8041 gagagtgggt tgacaggctc ccttgcagac tgccagcgcc gtagagcgcg gacagcagtg
     8101 cctggaagag cgccgttttg cccgagccgt tctgaccgat catgacaatc agaggacgct
     8161 gagagccatc ttcgccgaga gagggccgga gatcgaagcg atgcttgccc gcaaagacgc
     8221 cggaatgctc aacagagcac tcgagaagca acatccaggg cctcctctct agcggaagcc
     8281 aaagctgacc acagagggga ggctcctgtg tggcggggat ggcctcggac tcctcggccc
     8341 actcctgata aaggatggcg gccagctggt tcaagatgct gcccgcttcg tgatatcaat
     8401 cgactgcttt tcggcctcca gcagttttgt gaccatctcg aagggcaagt catgctcttt
     8461 gcaaatcccg gcaagcagct ccttctgagt ggcatcgaag accggatcat cgtcgcagga
     8521 cctgggatcc attaaccggc ctcacttcct ggctggtacg cagtttcttg aaatgggggc
     8581 attccgtccg tgtctggcgg ccttccggag gaggacaccc tctccttgcg ggtcaggcca
     8641 ggcacagcgc ccagtgagcc gcttgtccct gccctcagtg ggggtgtgtc tgagtgctga
     8701 cggcagcgcc tggactgccc ggagccgcag caggctcgcg ccactgccag gatagccgtg
     8761 ctctctggga gcatcctggg aagcgggcgg gaagcaagag ggaagcctgg atcaggaagg
     8821 ggaggagaag cctgtcacgt gcacgggaag cagcaggcga gacggtgccc gaagatggag
     8881 ccaatgccac atacggcgga agatctgatg cgaggcatcc acggtgtgag ctcccaggcg
     8941 ccccaattgc cctggcgcgg ctggcgacgg acagcccgtc tctgggagca actcctgcat
     9001 cagcgccgcg atcaccctcc aatggagggg atgcccatag ccgcgagcac aatgaggagc
     9061 tccatcaggc gcctcctcgt ccccggcgtc gctggcgacc tcggatggca tccgcccggc
     9121 accattgctg gcccttcagc gtcaccagcc agcttgtcat cactcctccc tccgtggagg
     9181 aggccctgca ggcgaaggag agtggccagg cgcgcgtgat tctcttcaat ctctccgacc
     9241 acggccactt tgacatgcag gcctgcgata cctgtatttt gcgggtcagt tgcaggactt
     9301 cgaatatccg gttgaggcgg tcagcgctgc ccagcagcgc ctgccccagt ggtctgatcc
     9361 ctcgccggtg cctcccgaac gcgatgagag ggcgaggcgc cgcgcgacct gtggagatgg
     9421 gtacggcgtc agtggccagt cccccctccc tcgcgcgcgg tcgccctcgc cagcgctcgg
     9481 ctggcacctg ggccgtcagg acgaccgtgg ctggaagcgg cgcgcggcgc ggatcaccca
     9541 gaacacacag gcgcccagca aggtgagcag cccgagtgcc atcagcgccc ccggagcgtg
     9601 catccggaag agaaaggagg cgccctgact ggtaaagtcg aagatctcca gcgagaagag
     9661 cttcagatgc acttcctgct gagggtaggt caccccgtag atgaagattc ccagaaggcc
     9721 caggatggcg atcagcagcg ccagcatggc tccgatagag atgccggtga cgatgttgct
     9781 gatgagtgtt tcggcgaacg tctgccgtgt cgctgtcccg gttggcgcat tcctgctcat
     9841 ggttgtggcc tcctttcgta ttcagcagga gaaagcggcg cctgctccat ctgatcatgc
     9901 acttcgttcc tgcgatgact ggagcgcagc acctgaacta tattgttaag atcaggattg
     9961 ggtagtaaaa gctgtaaaaa gatgtacacg aggagcgcga tcagtagcca gtccagcggc
    10021 caggggtgga gcaggtgcca gaccagggca agcagcccga tgctgccggg aagcagcggg
    10081 ccggccgcat tgaccgcgat ctccgccgcg gggcgcgcca ggggggacgt atcaggcgta
    10141 gcaacgggcc ggtgcgcagc aaaaagccgc tccctgcacc gcagtagtgg tgcaggacga
    10201 tcaggtgacc gccctcatgc aggcagatgc tgagcgtcag gcagagagcg agcgccagat
    10261 aggccagggt caacagcggc aggactgcca gcagcgcgcc ggcccccgct gccccaagca
    10321 gtcctgcgct cagcaccggg agccaggccc gccagacctc cagatagagc cagccgagga
    10381 gcagcagcgg attggtagtg agcgggggat cggagcgcca ggtgtacagt gccggcagcg
    10441 ttcgcgttcg cagagcaagc agccagcgta tactccgctg gtgccaggtc tcatgccagt
    10501 tgagcaggcc atggtggtac agctccaggc tcagttggcc caggtccttg agcagcacct
    10561 cccgtggctg cctgtagcgt tccgcgagtt gctcggcgat gctggcgaag ctgcgacggc
    10621 cgtcgatcag tgtgaggaac tcgcgggccg tgctgttcag cggatagtgc tgccgcaacg
    10681 cgcggtcctc cagagaagcc gtgtgcacag ccacgccggc ggggagcacg ggaatcatct
    10741 caatcacgat ctttctccat cttcacgtcg gcaagctgat ggattcccag atagagcatg
    10801 cccatgatca gcagcgccgc cgctgtctgc acgagcatct gcgccgccat gccgccaggc
    10861 agccgcgcca gtgcctcctg ggcctgctgg aagagcacgt agagcggcgg acccagggtg
    10921 accatcaccc ccgacaccat gagcatcgag agcgggtttt cgggcgagta aggaagcacc
    10981 ccgtgcagag cagtggcagg cgctgcagca ggagcagcgg gttgttgccg gcccaggtaa
    11041 ggacgcctat cagcagcacc cagccaccga cgatcaccac caggttggcg gacagcttcc
    11101 catcgagcag gaggtgaaca tctagcggcg tactggccag cacgtgatag gcgcggctgt
    11161 cccgccccca ggacatctgg gcgatggcgc agagcaggaa cgttatgaga tcgagggcca
    11221 gttcgagcag cccgtagctc agcagcggat tgctggcgcg tgtccagaag acagcgacgg
    11281 tggccacaag ccagccggcg acgaccatca ccaggccgac gaccagttgt tgatcacgag
    11341 cgatgccctt gagttcatag aggtagctac tcatgaagag cgaggatgga aaggagagcc
    11401 gtcgcagcgg cacccattgg cctctggttc ccactgccag gcgctcgcag cgctcaacgc
    11461 agaaggcgta gatgaccacc cccagcaggc cgagcgcgct caacaggccc agacccgcta
    11521 tagctctgag gaggtctgac tgcaggatta gcagtatcca gtaggctggc gtcagaatca
    11581 gccagccggg ctgccgggcc agcagcgcct gcgcccccag aatcagcggc agtgtgaaga
    11641 ggaccatgcc cagggccatg ctcactctca gtgccgtgct gcgcaggtca acgcgctcag
    11701 ccccaaagat gcgcgtggtc ccgtagagca ccgcctgatg gaatgccagg gtgattccgt
    11761 tgtaggcggg cagcccgaga aagaccgcca gcagtagctg caggggcgtg gctaggccca
    11821 cctgtatgag gaccagcagt gcaggcagcc agagcaggtt ctgggcagga ggaggatgaa
    11881 gccgggcaat aacaggccaa gacgctgctg catgggcgag atcgggaggg gggccaggat
    11941 acgtttgagc gtggtctcct ctggcgtaaa gagcagtgca aaggagacga gcgtgaaggc
    12001 tgtcaggctg aaggcgctga acaaggccgt cacgatgatc gtgcgtagct gcagaaaggt
    12061 gctgctgctg gatgcaatga actgagtgat cttgtagaag aagtcatagc tgagataggc
    12121 tcctccgcag tagctgatca ccgcgagtaa cacgaccagc cagagcgccg gcatacggcg
    12181 gaagagctga cgcaggcgat tacgccagat caggatcaca agcctagaaa tctgccagaa
    12241 cacgctccag tgcctcctcc tgctcttcaa ggccgagcgc cttgagaaag gcctcttcca
    12301 gattggccgc accatagcag gtcagcagct gctctggttc gcctgttgct acgacgccgc
    12361 cctggttgag gaagatcacg tgatcgcaca gctccccgac catcagcaga tcatgtgtcg
    12421 agatcagaat ccctacgcca cgctcacgga gcttccgcag gaggcgcttc accagcgcga
    12481 tcatctctgg atcaagaccc gaaaatggct cgtcgagcag cagcagctcc ggctggtgct
    12541 gcagcgcggc gatgagttgc actttcttgc gctggccgtg ggagtaggtt tcgaggagat
    12601 cctgcgcttt ggcttccatg tgcaggaggg ccaggtactc gttcgccaga ctccactgct
    12661 cggccgaaag cccgtagatg cgctggatga actgcaggta ctcccagccc gtcagatggg
    12721 ggatgacctc ctgcgagtcg gggacaaagc caaagacgtg cttcatctgc ggggtctcgc
    12781 tctgtgtctc ctcgccgtcc aggacgatgc tgccagccgt gggaggaaag agtcccacca
    12841 gcatagcata gagagcagcg ttgttttgcc ggcgccgttg gaacccagca ggccgacgat
    12901 gcttcctggc cgaatggcaa aagagacctg atcaacagca gtgaaggttc cgaagctctt
    12961 ggtgagcctc ttgacttcca gtagatactc ggctcatatt ttctcgcttt ttctgctcaa
    13021 gagcatagga tacccgaaat tgactaatca taccacatag cctgtcctat ttctagagca
    13081 tttgaggaac ggcgagcaga agacggagcg agtcagggtc ggctgctccg tcttctgccc
    13141 ggtgcccgga tgacgcccgc tggcgtctac ttgcaggcga tggtgactgt gccgctccag
    13201 ttgatgtgcc aggtcaccac tacactctga ccgtggatca cgcaccagat agccactgcc
    13261 aggacgatgt cggcagccag ccccaggagg atcagcagcg gtacgacgta ccaggctaga
    13321 ggcgaagccc gctgctcgcg cttctccagc agaacgacag gggcgacata ggttgtcaga
    13381 tgctgactat gcatcgcttc acctcttctg caacgttact tgctgcagcc gatcgtaaca
    13441 aagggccagt gtacctgcca ggagatcacc tcgccaccac cgtggagcga gcaccagatg
    13501 cccatcgcta caatcagcgc ggccgccagg accagcaaga cgatgagggc aactacccac
    13561 cagacgatgg gggtctcctg ggtctgacga gtggacaacg ctaccagcgg cctggaagca
    13621 gcacaggaaa agacaggctg ttgcataggt gctgacctcc ttgctggcta tttgctacag
    13681 ccgatggtga cgtagccatc ccagctgatg ctccatctca caacgacgcc accgccgtgg
    13741 aaggcacacc agagaatgac ggccagagcc agcacggccg cgatggccag cagcatcgcg
    13801 agcagcgcca cccaccagat gacgggagag agcagaccct cacgctcgtt cagttcgatg
    13861 gccggaggaa gaagcgtaca cgacggtggt ggaaaacgtc tgggaaggaa gcgggagcgt
    13921 agcaggaaga gagcgggaga gtgagagact ggcagtgggt gcgcaacggg agtagcctgg
    13981 gaaggcagca gggaacatga cagtcaccct ttttagctga gccgtgagag gacagggcgc
    14041 ccagcgacgg ctggcaactg accaagtacg ccagggatgc ttgcccttta cgagggcggt
    14101 ctggctattc gtctgcagtt gctgcatagc cgcttaagat caaatctgca gtaacatacc
    14161 cagcttcttc taagcgtacc atctgattga gagaggcagc ttaggagagg tcacagaatg
    14221 cgtaaaaatc actgttatac gctagctttc aaaagcccca atctagccgc gactcagacc
    14281 ttcagaattc ttgtaagccc gacctaaata tataaaagga acacctgcta cctctctctt
    14341 tgagaacccc attgtcagcg acttgattgc tcctattgga cggcgtggtg ctgtccgcaa
    14401 gttgctcttt ggcagcaggg tagcagcctt gacactgctt ggagaagcgc ctggagtcag
    14461 cgctgcctct cttggctacc agggcgttgg ccaggtccgt ctactgcttt tgtctcttgc
    14521 ggaacgtgcc tcgttcgggc aaaaatcgca ttgatgtgcc cactcgatct tttttattta
    14581 tagaaatgta agacatctat caagcttgtt tttttatcaa aaaatagatt tttactaatt
    14641 gatgaggata taaccgttat ggaaaaatga tctctgttaa gagagctggt atatacagct
    14701 gttttcatag actcatattg aacttttttt ctgctcaggt aatgtcctcc cataaagtgt
    14761 ccttcatcgc ttgcttccaa cactgaagcg gaagtaagcg gtgaaggctg ggcttaagct
    14821 gctcgttgga tgcccctttc gggtagaagt catcctcgca tcctggtaaa gtaaattgct
    14881 cactggggca agagcctgaa agctctctat aattgaaatt ctgttatagc gcgacatccc
    14941 gcttatgcac cagcaataga ctcactcctc cactgatcag cccgtagcag agcaggaccg
    15001 ctccagccag tgcagtactg gcactcgacg gcactgcact cgcgactagg ggcagcggac
    15061 gagaggccag tgcctccagc agcgtatggc aggccgggcc caagaagagc gcgggaaggt
    15121 gcctcagcaa cgcagtgaac ccgctgtcgg gcagggcact tagcatggag gtcagtggag
    15181 ggagcagcag gccctggatg aacagatagc cgatcgaccc tgcaataccg gcccctatcg
    15241 agcgccctag cgtcgtgaag agcacgctga gcagcgcata gagccacaga ctcacacaga
    15301 tccccagcca gtatagggcc agctctcccc agccttggag cgaaagtgga cttagcttcc
    15361 ctcccagtag gggaccaatc acacagccca gcagcgcccc tgccatgagc agcgcggcgc
    15421 taacgatcac caggatcagc agcagcatca cagattgcgc gcagacaagg cgggtgagtg
    15481 gaacaccgcg caagaagacc agatgctgcg tccctgcctg atagtcgctg ccgacaaaga
    15541 tcgcgacgaa gatgcacaac agcagtaccc ctagcgagag cagcgtgtcg ccacccaggc
    15601 tgagcgacat aggaaaggtc agcgtcgtct tttgctcacg cagcacctcc tgacgcagca
    15661 gtttctgttc tgcctgctgc tgaggtgttt cgctcacgca gggaggcgcc tggctaacct
    15721 gctgagcaga ggtgctggca gtgggacaag cctgcgccga cacaggcagc gtcgcaaaga
    15781 cgtagaggac gaggtggaag cctgtcgcca gcagaaagcc cccgcccagc agtgccagta
    15841 ccaccagcgt cagaacacgt ctgcgcacca gcaggagctg agccttcatc actgtgatga
    15901 tggcatgcca tcttatacgg atggagggat atccctcggt cagtaaaggg gcgagtctcg
    15961 actgcatcat tctctcctct caaactcacc attcagagcg ctctctgagc ctgactcagc
    16021 gtgggtgccg gctctgacgc ctgatccaag aagaattgct caaggcttat ggaacgcctg
    16081 cggatttcgg caggatagag tgcatgtctg gccagcagcg cgcagatctc tgtggaggat
    16141 gtgatcggag cctggatctg gagcacacag gggtccgcca ctctggcctc cgcgctggac
    16201 accgacgctg cgcttccggc gcgcctgacc tggcgtatcc aggcgggctg ctcctgagca
    16261 gtacgctgga ggagcgcctc agcagcgtcc agtgcctccg gggtctcgta gacgacctca
    16321 atcacaccct gggtctggag cagtcggctg acctcgccct ggatcagcac ctgcccacgt
    16381 ttcagcagaa cgaccctggt gcagagctgt tgcacttcgt gaagcaggtg gctggacagc
    16441 aggatcgtcg tgccttgctg tgccagggag cgcagcagct cgcgcagatg gacaatgcca
    16501 atggggtcca ggccgttggt tggctcatcg aggaccagca attccggctc cgtcagcagc
    16561 gcggcggcga ttcccaggcg ctgtttcatg ccaagcgagt actgcttgaa ggccacagga
    16621 ccctccacag gcagggcgag gcgctcgagg agttgactga tgcgctgctc tgtctcgcgg
    16681 tcctccggaa ggccggccag cagcgagact acacgcaggt tatcgcgtcc actgagatag
    16741 ggatagaagg tcggggcctc gatgagcgct ccgacacgtc gcagggcttc cccgcgccga
    16801 accgcggagg tcataggcac accaaagagt gccacgctgc cgctggtggg agtcagcatg
    16861 cccaacagca ggcgcagcac ggttgtcttg cccgcgccgt ttgggccgag cagtccgacg
    16921 atctcgccgg gctgagcgat ttccaggctg aagttctcca cagcgatctg ctgctgaaat
    16981 cgcctggtta ctcgctccag ccgaacgatg ggagcgtctt tcccggacgg cgttgaagca
    17041 acgtgttgca tagcaccatt ccttgtcgat aggagagtac tgcttgctat agaagggacc
    17101 agcctctcag gcatactcgc gttagaggcc gcagggggcg agaggcgcag gcggtggccg
    17161 aaggagggga tgcgctggcc gaagggagat cgcgcattcc ccctccgtct caggaatgcg
    17221 tcagggcggg ctgatgctca tcgctcttcc cacgcacttg cctgaacagg gtgaccagcg
    17281 aatagagata tccgccgatg tagccagtca ccaagatcag caccagccag cgccagcgcc
    17341 gggttcgtgc ggtcagcacg aggccccaga cccaggccac aaaggagagg acgtcgatga
    17401 tcaaagcgcg cggacctggc acggagatcg tgccaggcat cgcgtgtttg atggcctgca
    17461 tggattctgc gaagccgcca ctcaattgca gcacgatcac tgtggtgcag atgaccagca
    17521 gcaagacgat agtccattga cgtttcatgc gccaggaatc cctccttgtt ccaggaattg
    17581 cttgcggctg atgctgttgc gcacggtgat ccccggcagg ggcgagcgcg agacgaaggt
    17641 gaggggattg ccggaggcgt ccacctcgta ccagccgctg taccgtcgta tcaggagcat
    17701 ggaggcgaca gagaaggtca ccagcactgc gacgctcagc acaacgagtg tctctgcgcg
    17761 catgatcagg aaggtcacga ccagcgcaga cagcagcgtg gttccgatca gcccgatgag
    17821 gggatagtat cggtgggtgg catagcccag aggcggctcg ccgctgcgca cccagtagcg
    17881 ccgaacaacc agcatccgat tctccgttga ctgtttcatt gttgtccctg cctttctttc
    17941 cttccggctc cgaggcagag tatacctgtg atccactccg cactcgttcc gcattggctc
    18001 tctgcggaga gccttggtgc gttatataac ggtaatgcga aaagatatga cctgcggcac
    18061 ttcctctgcg ggggccaggc cgctatcctt tcctgtggat agcgcacagc gagtcgctcc
    18121 agggagggag caggctgcag gcgccctcct gcggccctgc agtctgcggg atggccgcta
    18181 gatctcctcc ttcctctctg gagcgctccg gtgaggccct tatctatcag ctgatagtgc
    18241 gtgcgcacct ttctgctggc cagagggtgg actcgcgaac catcagaggc cagatccatg
    18301 acgagatctt tacgcaagaa agacctcacg cattgaagga ggaatcagac atgatgcata
    18361 cgcttacgcg cgtcaggttg cagatcgcca cgaaggtgac cctgctctcc agcctgatca
    18421 tggcgatggt cgtctccgcg atggcactgc cccgtggcct gggctttctg gtcagtcagt
    18481 ttggcctctc ctggcaggat gctctggcga tcatctctat cttgctcacc gaagggtcag
    18541 ccggtattgc tgcttttgct ccctggctgc tgccgtttgt gggcaccctc gatgggctga
    18601 tcctgtttat cggcgtctcg gctgctgccg gctggtagag ggacgtctgc tgtttctcac
    18661 tcgttattcc tattactgaa ggagtgaacc atgcaacaga cacttgctcg tgtatccgcg
    18721 aagtatgctc cgaccgctgt ctcgctgctc tccagcgcgg cgctgctgct gacgcagggc
    18781 cgtctgctcc tgggctggct cgttggtcag ttcggcctct ctgaggcggt ggcggcgctg
    18841 attgtgagca ttatcacgac ggacggcatc tgggcggccg tggcactcta tcccttcctg
    18901 gcgccatttg tgggaaccgt ggagggactg gtcttcctct tcggcacatc tgtattggtc
    18961 ggctggtaag actacaatgg agtgcaagca acaacaccgc gctccaacct ggacgagtag
    19021 agcaatcctc ttgctctact ctctaggcga tctacgcgca cagggattgc tgcagcagag
    19081 acgctggtgg catcgtggcc tgagcatcct ggcggggctg atctgctttg tgacgctcta
    19141 tcgcagcgcg gcggcggccc tggcgcatcc ctttgtggcg gcggctacac tgccgctggt
    19201 gctcactgtc tgtgcgtttc tgctactggt ggtgaacgcg ctcgccgtcg gcacgctcag
    19261 tgagacctcc gggctggagg aggtgcgtgc gctgtgctct ctgccggtga cggtggccga
    19321 cgttgtctgg attcgcctgg tagtgggtct gctgcgctcg gagctggtcg cgctgatctt
    19381 ctttctgcct gtctgcctgg cgacgatcgt tcatcttgga tgggcgccct ggccgattct
    19441 ggcctctctg acgatgctgg tcgcctttcc actgttgccg gcggtgctgg gggtggcgct
    19501 caatctgagc gagacgaggc cgcggcttgt cgtctggttc agcgccttga ccagctcgct
    19561 ggctgtcgga gtcttcctct ctcagcaggt tccgctgctg ccggggccac tcgcgctgct
    19621 gggggcggtg ctcagcctgc cggtacgcgg ggtactggcg caggcggcgc cgggtgagac
    19681 gctgctcttc gctggcgcct ggacgctgct ggcggctgcc gcgggatggg tcctgatgca
    19741 tcaggtgagc gtgagtcgtg agaggcaggt ccgtgaacgg agatcgctgg ccgtctcgct
    19801 gctgcggacc tggctcagcg ccgctggagc ggcgaccggg cgttggggcg cgctgctctc
    19861 cttaagtggc ctggcgctgg cgcgtctccc ggcgttcctg ctggcgacgt gtacgctggc
    19921 cctcgcgctc tggctgagca tcgctccgcg cctgctgccg acccatacgc ttggcagtcc
    19981 ccgcctgacc gctctgatca cggccctctc gctgctcctg caaagtgtag tggcgctggt
    20041 ggtctgcctg gggccgctgc tcaccgcgct gctgggtgag gcgcgggaac atcgcgtaca
    20101 gcagccgtat cccattgcag cccgtctgca cgccgcggct gtctacctga cctttctggg
    20161 gctggcggtc cccctggtcg tggcgctggc cctgctggca ggtctgctca gccatagcgt
    20221 gctgctgtac tggtttggcg cctatctgct ctcagcgctg ccaggagggg gggcgctcct
    20281 gctggcgatg gtgctgggac gacggccatg gatcagattg ttcgcctggg gggccggctg
    20341 ggtacttgtg ctgctggccc gggtggtcgc cctggctgcg ggggtggcgc tgctgcgggt
    20401 tgatcctctg ctcctggggc tgctgagcgg tcttctcgtc gatgtgctgc tctgcctgct
    20461 ttgctggcgt gggctgatgg tgcgccagta caggcgtttt ctggaggagg atctctgatg
    20521 gctcattcca gacagtggtt tgccgtgctg ggggcctatg gctgcgggct gctcttgggt
    20581 ctgctggcag cggagggttt ggctcaccag cttgtggcac accctcatca gttgccagca
    20641 ctggcgatta tccagcataa tctgctggtg ctggtcatca tgtttctagg catcctcacg
    20701 gtcggcgctg tgaccttgct ggtactgctg atcaatgg
//
