LOCUS       NZ_CP031264            11366 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Peterkaempfera bronchialis strain DSM 106435 chromosome, complete
            genome.
ACCESSION   NZ_CP031264
VERSION     NZ_CP031264.1
KEYWORDS    RefSeq.
SOURCE      Peterkaempfera bronchialis
  ORGANISM  Peterkaempfera bronchialis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Peterkaempfera.
REFERENCE   1  (bases 1 to 7090212)
  AUTHORS   Nouioui,I., Klenk,H.P., Igual,J.M., Gulvik,C.A., Lasker,B.A. and
            McQuiston,J.R.
  TITLE     Streptacidiphilus bronchialis sp. nov., a ciprofloxacin-resistant
            bacterium from a human clinical specimen; reclassification of
            Streptomyces griseoplanus as Streptacidiphilus griseoplanus comb.
            nov. and emended description of the genus Streptacidiphilus
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 1047-1056 (2019)
   PUBMED   30741626
REFERENCE   2  (bases 1 to 7090212)
  AUTHORS   Batra,D. and Gulvik,C.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUL-2018) Bacterial Special Pathogens Branch, Centers
            for Disease Control, 1600 Clifton Road, Atlanta, GA 30329, USA
REFERENCE   3  (bases 1 to 7090212)
  AUTHORS   Gulvik,C.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2018) Bacterial Special Pathogens Branch, Centers
            for Disease Control, 1600 Clifton Road, Atlanta, GA 30329, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2018
            Assembly Method                   :: HGAP v. 3; Pilon v. 1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 176.4x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003258605.2-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:52:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,114
            CDSs (total)                      :: 6,019
            Genes (coding)                    :: 5,833
            CDSs (with protein)               :: 5,833
            Genes (RNA)                       :: 95
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 186
            CDSs (without protein)            :: 186
            Pseudo Genes (ambiguous residues) :: 0 of 186
            Pseudo Genes (frameshifted)       :: 60 of 186
            Pseudo Genes (incomplete)         :: 147 of 186
            Pseudo Genes (internal stop)      :: 2 of 186
            Pseudo Genes (multiple problems)  :: 22 of 186
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:20:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5258635
            Orig. end                         :: 5270001
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031264.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11366
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="16"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11366
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11366
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6366](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6366)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(312..1316)
                     /locus_tag="C7M71_RS23305"
                     /old_locus_tag="C7M71_023305"
     CDS             complement(312..1316)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025616.5"
                     /locus_tag="C7M71_RS23305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023305"
                     /product="DUF4349 domain-containing protein"
                     /protein_id="WP_162824335.1"
                     /transl_table=11
                     /translation="MGGRAGAAAGGVLLAALALLGSGCSADSSAKDEASARSAVGKADR
                     PAAKVAPSGPAALAGGPSAAATAGRSIAYTAELRLEVKDVPAALERLRSMTSAAGGYVS
                     SENLDRGSFEEAAADQESSWVEGASEVVVKVPSAAFDRTLDTFGGLGKVLQRHREAADV
                     TDQVVDVESRLKTQRASVQRVRALMGEATTITEVVALESELSRREADLESLERQQQELA
                     SKTSLSTITVGLSSVAPPASAPAAKENRGFWGSVGHALAAGWHALYATVRGVLVVLAAV
                     APFALVLVPAGWLAVRLRRRHGTAAPALAEPAAAVEPAERPEYPAHPERADNG"
     misc_feature    1470..1487
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 18.25"
                     /tool="antismash"
     gene            1703..3214
                     /gene="hemG"
                     /locus_tag="C7M71_RS23310"
                     /old_locus_tag="C7M71_023310"
     CDS             1703..3214
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010274182.1"
                     /locus_tag="C7M71_RS23310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023310"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_114914519.1"
                     /sec_met_domain="DAO (E-value: 2.5e-08, bitscore: 32.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRSAVADRSSDPGPWSENGPPPQVVVVGGGIAGLAAAAFLSGAA
                     GGLGRRARVTVLEESGRFGGKLRTGEVGGVAVDLGAESMLARRPEAVALAREVGLADQL
                     EPPATAKATLWTRGALRPMPTGHVMGVPGDLAALERTGVLSPEGLARARQDLDLPPTEV
                     GDDVPLGAWVAARVGREVVDRLVEPLLGGVYAGHADRISLRAAVPQLLPVAQRGGSLVA
                     GVQELQQRAAATAPAEPQPVFQGIAGGIGRLPLAVADAARAAGAELRTGTAVQSLRRTP
                     EGWRLVVRDSAGEREVTADAVVLAVPAPVAARLLAAEAPGAAAELAAVEYAGMALVTMA
                     FHRSELPGTPPGSGFLVPPVDGRTIKASTFSSNKWGWLDRAAPDRFLLRTSVGRHGETA
                     DVALPDAELVARSLADLREAIGLRATPYATEVTRWERGLPQYPVGHLDRVRRIREQAVG
                     HGTLALCGAAYDGVGIPACVASARRAAEEVSAALAVAGGPVNERR"
     misc_feature    complement(3222..3237)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.65"
                     /tool="antismash"
     gene            3235..3942
                     /gene="hemQ"
                     /locus_tag="C7M71_RS23315"
                     /old_locus_tag="C7M71_023315"
     CDS             3235..3942
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138586.1"
                     /locus_tag="C7M71_RS23315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023315"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_111493527.1"
                     /transl_table=11
                     /translation="MSESTQPEKKKARDLNQVVRYTMWSVFRLKEALPDDRSGYAAEVD
                     ELFAQLREKDVVVRGTYDVSGLRADADLMVWWHAETSDALQDAYNRFRRTALGRHLEPV
                     WSNMALHRPAEFNKSHIPAFLADEEPRGYVCVYPFIRSYDWYLIPDEERRQMLAEHGKM
                     ARGYPDVRANTVASFALGDYEWVLAFEADELHRIVDLMRHLRGSRARLHVREEVPFYTG
                     RRKPVAELLAGLV"
     gene            complement(3997..5001)
                     /locus_tag="C7M71_RS23320"
                     /old_locus_tag="C7M71_023320"
     CDS             complement(3997..5001)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="C7M71_RS23320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023320"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_111493521.1"
                     /transl_table=11
                     /translation="MHLEFTLACTAMLAASMNAGWANSRLRRVPAPQGLPGRGLPLLDT
                     AFLAGGPARVAEVALVWMHQQGRVVVSRSGLVTVTDPQPWNEVEAALIAAAGPGRQRSL
                     PGLRREVMRSPAVQSIGERLADRGLARRATAHRRARIARRLLGVAMLLTMVLGAVATFR
                     WMEDHFGLTGDGEPGFPPFFAFAGMFAYGLLVLALTGPGRGQISPAGRRQLQLMRAGDR
                     PWRPHDALAAPDPLLLGAVALGGTMLLTDPALREVLAPPVSSGPAGSGGGGFTGGAAAA
                     VWCGSATGGQDGGSPSACGSSSSCGTSSSCGSATSGCGSASSCGSSSSCGSST"
     gene            complement(5001..6366)
                     /locus_tag="C7M71_RS32090"
                     /old_locus_tag="C7M71_023325"
                     /pseudo=""
     CDS             complement(5001..6366)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481895.1"
                     /locus_tag="C7M71_RS32090"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023325"
                     /product="DUF692 domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="DUF692 (E-value: 1.2e-84, bitscore: 282.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERSTPPPLLGVGIGWRAEIDTVVERLPGVDWVEVVAENIRADRL
                     PESLRLLRERGTVVVPHGVSLGLGGADLPDPARLDGLAARAEALDAPLVTEHLAFVRAG
                     GGRTGLPRLEAGHLLPVPRTRDALAVVAENVRIAQRELPVPLALENVAAQLAWPDAELS
                     EGEFLAELVERTGVGLLVDVANLHTNRVNLGLDPAAELSRLPLEAVAYVHVGGGVQADG
                     VWHDTHAHPVTEPVLEVLAELCSRTVPPGVLLERDDDFPPPAELAAELATVGGVLRAAR
                     RRAAEVAAGV"
     gene            6719..7855
                     /locus_tag="C7M71_RS23330"
                     /old_locus_tag="C7M71_023330"
     CDS             6719..7855
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M50"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543158.1"
                     /locus_tag="C7M71_RS23330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023330"
                     /product="site-2 protease family protein"
                     /protein_id="WP_111493519.1"
                     /sec_met_domain="Peptidase_M50 (E-value: 1.1e-09, bitscore:
                     36.4, seeds: 56, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGSMGLGRVFGIPLKVHWSVPLLLVVLGYDLGREVLPPWVPGRS
                     GAVYAVAGLVGAVVLLASLVLHEGAHAVVARRGGVKVEDMTLWALGGVTRMGPPQTPRA
                     MLAVAGSGPLTSLVVGGVLLGAGVGLHAALGWGVVPALLVWLGAANLLLGVFNLLPAAP
                     LDGGRVLQALLWMRSGDRLRAEQVADQSGQVVGYLLIALGVVSVLGGSAGGFWLALIGF
                     FVAVTAGAERRRAMLGSALRGLRVADAMSAPVETGPDWQTVARFVDDAVARSHHSALPL
                     VDFEGRPSGLVTLRRLAAVPPAQREQVRVRDVAQPLARCATAEPGEALAEALQRAAQHG
                     GSRLLVVDGGRLVGIVTGHDVARLMHRHALVDHPGHAA"
     gene            complement(8004..8426)
                     /gene="msrB"
                     /locus_tag="C7M71_RS23335"
                     /old_locus_tag="C7M71_023335"
     CDS             complement(8004..8426)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016470510.1"
                     /locus_tag="C7M71_RS23335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023335"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_111493517.1"
                     /transl_table=11
                     /translation="MAQETGKYRIEKSDAEWRAELSPAEYHVLREAGTERPHTGEYTDT
                     TTVGVYSCRACGAELFTSGTKFESHCGWPSFYSPLAEDRVEYIEDSTLGMRRVEVRCAH
                     CGSHLGHVFEGEGYPTPTDQRYCINSISLRLRPAEG"
     gene            complement(8464..9879)
                     /gene="murC"
                     /locus_tag="C7M71_RS23340"
                     /old_locus_tag="C7M71_023340"
     CDS             complement(8464..9879)
                     /EC_number="6.3.2.8"
                     /GO_function="GO:0008763 - UDP-N-acetylmuramate-L-alanine
                     ligase activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="murC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138595.1"
                     /locus_tag="C7M71_RS23340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023340"
                     /product="UDP-N-acetylmuramate--L-alanine ligase"
                     /protein_id="WP_265737673.1"
                     /transl_table=11
                     /translation="MSDAPSDLHAPHFIGIGGAGMSGLAKILALRGAEVSGSDARESAT
                     TAALRAAGAEVAIGHAAGQVPETASCVVVSSAIREDNPELVAARERGLPVIHRADALAA
                     LMHGRRALAVAGTHGKTTTTSMLAVSLAALGLDPSYAIGGDLDEPGSNAHHGSGEIFVA
                     EADESDRSFHKYAPEVAIVLNVELDHHANYASIEEIHESFETFVGRIEPGGTLVVSADH
                     SGARELTSRVSDRPDLRIVTVGESADASLRILSVVPRGMSSEVTVEPAGTDGAPLTFTV
                     SVPGRHYAHNAVSALAAGIALGVPAEELATALGSYRGVRRRLQLKGEAGGVQVIDSYAH
                     HPTEIAADLEAIRQSAGGGRVLVVFQPHLFSRTQQLGTEMGQALALADAALVLDIYPAR
                     EDPIPGVTSEVIIDAARGHGLETVPVHTMAEVPEAVAALAKAGDLVLTMGAGDVTGLGP
                     EILARLAGVEAGV"
     gene            complement(10014..10472)
                     /locus_tag="C7M71_RS23345"
                     /old_locus_tag="C7M71_023345"
     CDS             complement(10014..10472)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138596.1"
                     /locus_tag="C7M71_RS23345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_023345"
                     /product="indole-3-glycerol phosphate synthase"
                     /protein_id="WP_229758870.1"
                     /transl_table=11
                     /translation="MFTTVLMIEKALSEADIELVTTLHGEEKTSFVVLMQPRGRQDELL
                     RALDDVALGRLEEAVHERDEDDTATPADQALAHTLDRLHAAGSDAVGHVVSDNPLGMLR
                     TVVEDTGADEVIVLTSPHFVEEFFHRDWASRARHRVGVPVLKLFAHDV"
ORIGIN
        1 ggacgaggcc caccgccggg tcggccccgg caaggcgctc cagggcaacc tcgacccggc
       61 ggtgctcttc gcccccgagg cggcggtgcg cgccaagacc gccgaggtgc tggcggcggc
      121 cgaggcgctc ggcggcaccg gccacatctt caacctcggc cacggggtgc tgcccaccac
      181 cgacccggac gcgctgaccc ggctggtcgc ccacgtccac gaggcgaccg cgcgctgacc
      241 cgccgtcccg ccccgccgtc ccgccccgcc gcgcccccgg aaaccgggcg cggcggggcg
      301 gtcgcgcacc gtcagccgtt atcggcccgc tcggggtgcg cggggtactc gggccgctcg
      361 gccggttcga cggctgcggc cggttcggcc agggccggtg cggccgtacc gtggcggcgc
      421 cgcagccgta ccgccagcca cccggcgggc accagcacca gcgcgaacgg ggcgacggcg
      481 gcgagcacca ccagcacccc ccgcaccgtc gcgtacagcg catgccaccc ggccgccagc
      541 gcatgcccca ccgaacccca gaagccccgg ttctccttgg cggcgggcgc cgacgcgggc
      601 ggggcgaccg aggagaggcc gaccgtgatg gtggagagcg aggtcttgga ggccagctcc
      661 tgctgctgcc gctccagcga ctccagatcc gcctcccggc ggctcagctc gctctccagc
      721 gccaccacct cggtgatcgt cgtggcctcg cccatcagcg cccggacccg ctgcacgctg
      781 gcccgctggg tcttcaaccg gctctcgacg tcgaccacct ggtcggtgac atccgccgcc
      841 tcgcggtgcc gctggagcac cttccccagc ccaccgaagg tgtccagggt tcggtcgaag
      901 gccgccgagg ggaccttcac caccacctcg gaggcgccct ccacccagga gctctcctgg
      961 tcggcggcgg cctcctcgaa gctgccccgg tcgaggttct cgctgctgac atatccgccc
     1021 gccgccgagg tcatgctgcg cagccgctcc agcgccgccg gcacatcctt gacctccagc
     1081 cgcagctcgg cggtgtaggc gatcgagcgc ccggccgtcg cggcggcgct cggaccgccg
     1141 gcgagcgcgg cgggcccgct cggcgccacc ttggccgcgg ggcggtccgc cttcccgacc
     1201 gccgatctgg ctgaggcttc gtccttcgcc gaggagtcgg cgctgcaccc gctgccgagc
     1261 agtgccaatg ccgccagcag cacgcccccc gccgccgccc ctgctctgcc gcccattcgg
     1321 taccccctcg tccggtgcca cccccgccac tcggcggtgg cctgccccct tggaccgccc
     1381 gccaccgggg cgggttccgg gcgacgcatc gcgaaagggt cacgtttgcg gccccggcgg
     1441 gcccgtttgg gggccgggcg tctgctcggt atccctttgt ccggtgtcgc ctccgctcgg
     1501 gcgtcgcgtc gcgaacgggt tggcgtcctg gtgggtccgg tcggcctccg tgctcggggc
     1561 gacggggcct ttcgggggcg gcccgggtgt ctgctcggta cccctcgtca gggttgccgt
     1621 cctggtgggt ccggtcggcc ctttgggggc gggacgacgg ggcctttcgg gggcgggccg
     1681 ggcgtctgcg agagtgggag gcatggaccg aagcgcagtc gccgaccgaa gcagtgaccc
     1741 cgggccgtgg tcggagaacg ggccgccgcc gcaggtggtc gtggtcggcg gcggtatcgc
     1801 cgggctggcc gccgccgcgt tcctcagcgg cgccgccggg gggctgggcc gccgtgcccg
     1861 ggtgaccgtg ctggaggagt ccggacggtt cggcggcaag ctccgcaccg gagaggtcgg
     1921 cggggtcgcg gtcgacctcg gcgccgagtc catgctggcc cggcggcccg aggcggtggc
     1981 gctggcccgc gaggtcggcc tggccgacca gctggagccg cccgccaccg ccaaggccac
     2041 cctctggacc cggggcgcgc tccgccccat gcccaccggc catgtgatgg gtgtccccgg
     2101 agacctggcg gcgctggagc ggaccggagt gctctcgccc gagggcctgg cccgcgcccg
     2161 gcaggacctc gacctgccgc ccaccgaggt cggcgacgat gtcccgctcg gcgcctgggt
     2221 cgccgcccgg gtcggccgcg aggtggtgga ccggctggtg gaaccgctgc tcggcggcgt
     2281 ctacgccggc cacgccgacc ggatctcgct gcgcgccgcc gtcccgcaac tgctgcccgt
     2341 cgcccagcgc ggaggctccc tggtcgcggg cgtacaggaa ctccagcagc gggccgcagc
     2401 cacggccccc gctgagccgc agccggtctt ccagggcatc gccggcggca tcggccgcct
     2461 gccgctcgcg gtcgccgacg cggcccgcgc cgccggtgcc gagctgcgca ccggcaccgc
     2521 cgtgcagtcg ctgcgccgca cccccgaggg gtggcggctg gtggtccgcg acagcgcggg
     2581 cgagcgcgag gtcaccgccg acgcggtggt gctggccgta cccgcccccg tcgccgcccg
     2641 gctgctcgcc gccgaggcgc ccggcgcggc ggccgagctg gcggcggtgg agtacgccgg
     2701 gatggcgctg gtgaccatgg ccttccaccg ctccgagctg cccgggacac cgcccggcag
     2761 cggcttcctg gtgccgccgg tggacgggcg caccatcaag gcgtccacct tctccagcaa
     2821 caagtggggc tggctggacc gggccgcccc ggaccgcttc ctgctgcgca cctcggtggg
     2881 tcggcatggc gagacggccg acgtggcgct gccggacgcg gagctggtgg cccgctcgct
     2941 ggccgacctg cgcgaggcga tcgggctgcg ggccaccccg tacgcgaccg aggtgacccg
     3001 ctgggaacgc gggctgccgc agtacccggt cgggcacctg gaccgggtgc ggcggatccg
     3061 cgagcaggcg gtcggccacg gcacgctggc gctctgcggc gccgcctacg acggggtcgg
     3121 catccccgcc tgcgtcgcca gtgcccggcg ggccgccgag gaggtctccg ccgcgctcgc
     3181 cgtggccggg ggcccggtga acgagcgtcg gtgacggaag ggagaatgaa gggcatgagc
     3241 gagagcaccc agcctgagaa gaagaaggcc cgcgacctca accaggtcgt ccgctacacc
     3301 atgtggtcgg tcttccggct caaggaggcg ctgccggacg accgctccgg gtacgccgcc
     3361 gaggtggacg aactcttcgc gcagctgcgt gagaaggacg tggtggtgcg cggcacctac
     3421 gacgtctccg ggctgcgcgc cgacgccgac ctgatggtct ggtggcacgc cgagacctcc
     3481 gacgcgctcc aggacgccta caaccggttc cgccgcaccg ccctgggccg ccacctggag
     3541 ccggtctggt ccaacatggc gctgcaccgc cctgcggagt tcaacaagtc gcacatcccc
     3601 gcgttcctcg ccgacgagga gccgcgcggc tatgtctgcg tgtacccgtt catccgctcg
     3661 tacgactggt atctgatccc ggacgaggag cgccgccaga tgctcgccga gcacggcaag
     3721 atggcgcgcg gctaccccga tgtgcgggcc aacaccgtcg cctccttcgc gctgggcgac
     3781 tacgagtggg tgctcgcctt cgaggccgac gagctgcacc gcatcgtgga cctgatgcgc
     3841 cacctgcgcg gctcccgcgc ccggctgcac gtccgcgagg aggtcccctt ctacaccggc
     3901 cgccgcaagc cggtcgccga gctgctggcc ggactggtct gacggtgccg cagcgccccg
     3961 cgccggtcgg gtcggcggcg cggggcggcg gctctgtcag gtactgctgc cgcagctgga
     4021 cgacgacccg cagctcgacg ccgagccgca accggacgtc gccgagccgc agctcgaaga
     4081 cgtcccgcag ctcgaagacg agccgcatgc cgagggcgac ccgccgtcct gaccgccggt
     4141 cgccgacccg caccacaccg ccgcagccgc gcccccggtg aacccgccgc cgccggagcc
     4201 ggccgggccg ctcgacaccg gcggcgccag cacctcccgc agcgcggggt cggtgagcag
     4261 catcgtcccg cccagcgcca ccgcccccag cagcagcgga tcgggggcgg ccagggcgtc
     4321 atgcgggcgc cacggccggt caccggcccg catcagctgc aactggcggc gccccgcagg
     4381 gctgatctgc ccgcgccccg gcccggtgag ggccagcacc agcagcccgt acgcgaacat
     4441 ccccgcaaag gcgaagaacg gcgggaagcc cggctcgccg tccccggtga gcccgaagtg
     4501 gtcctccatc caccggaagg tggccaccgc gcccagcacc atcgtcagca gcatcgccac
     4561 ccccagcagc cgccgggcga tccgggcccg ccggtgcgcg gtggcccgcc gcgccagccc
     4621 ccggtcggcc agccgctccc cgatcgactg cacggcgggg ctgcgcatca cctcgcgccg
     4681 cagccccgga agggaccgct gccgaccggg cccggcggcg gcgatcagtg ccgcctccac
     4741 ctcgttccac ggctgcgggt cggtcaccgt gaccagcccg gaccgggaga ccaccacccg
     4801 cccctgctga tgcatccaca ccagcgccac ttcggccacc cgggccggtc caccggccag
     4861 gaacgcggtg tccagcagcg gcaggccccg accgggcagg ccctgcggtg ccggtacccg
     4921 gcgcagtcgg ctgttcgccc aaccggcgtt catcgacgcg gccagcatcg ccgtacacgc
     4981 cagcgtgaac tccaggtgca tcagtgcccc cctcccgacc gccgtgcccg gcggccgatc
     5041 gactccagcg gcgcgcgcag ccgcgccagg accgccccgc gcggcgcggt ccccgtgcgg
     5101 tcggcgtgcc agcgggccag gccccggcgc tgaccggccg tcagcccctc ctcgtggcag
     5161 agcacccagg cggcgaacgc caccgcgtcg gcgcgatggc cgccggtcgg cggggtcgcc
     5221 gccgtatagc gccggaacgc cgggccgaac cgtccgccca gcaggacggg cagttctggc
     5281 gccaccctgg ccaccgactc ccgccgcttg gccgccagac ccccggcctg tacccggacc
     5341 tgccccgcgt caaagccggg cggtagcggg ccgcccgcca ccagggccga cagcagctcg
     5401 gcctgacggc gcgccagccg cgcccgggcc ggtgccgtgc cgggctcacc ggcgtcctcg
     5461 ctcaggcgcg gcaccaggta ctcgtactcc tcagacaccc gccgccacct ccgccgcccg
     5521 cctccgtgcc gcccgcagca ccccgccgac ggtcgccagc tccgccgcca gctcggccgg
     5581 cggcgggaag tcgtcgtccc gctccagcag gacacccggt gggacggtgc gcgagcagag
     5641 ctcggccagc acctccagca ccggttcggt caccgggtgg gcgtgggtgt cgtgccacac
     5701 gccgtcggcc tgcaccccac cgccgacgtg tacataggcg acggcctcca gcggcagccg
     5761 ggacagctcc gccgccgggt ccaggcccag gttgacccgg ttggtgtgca gattggccac
     5821 gtcgaccagc agcccgaccc cggtgcgctc caccagctcg gccaggaact ccccctcgga
     5881 gagctcggcg tccggccagg ccagctgcgc cgcgacgttc tccagcgcca gcgggaccgg
     5941 cagctcccgc tgggcgatcc gcacattctc ggcgaccacc gcgagggcgt cccgggtgcg
     6001 cggtacgggc agcagatgac cggcctccag ccggggcagc ccggtccggc cgccgcccgc
     6061 ccggacgaac gccagatgct cggtcaccag cggcgcgtcc agcgcctccg ccctggcggc
     6121 cagaccgtcc agccgggcgg gatcgggcag gtcagcgccg ccgaggccca gcgagacgcc
     6181 gtgcggcacc acgaccgtgc cgcgctcgcg cagcagccgc agcgactccg gcaggcggtc
     6241 ggcgcggatg ttctccgcga ccacctccac ccagtcgacg ccgggcagcc gctccaccac
     6301 cgtgtcgatc tccgcccgcc agccgatgcc gacccccagc aggggaggtg gcgtgctgcg
     6361 ttccatgggc gcccccttcg tgatccgcgc gaccggcggc cgggctccgt cgcccgtacc
     6421 cgctgccgcg ccgagatgtc aggccgcccc ctcgcggacg gcaccgggcc gagacccccg
     6481 tgcccggccc ggtgccgtgg atgtatcccg gcggtggacc cgccaatcgg cgggggcgat
     6541 tctcagagct tgatttgagc ttcggccgcc ccggagcgga cccggagcgg ccccggagcg
     6601 cggcgctccg cgcacggcct ccgcgcgggt ccgggccgtc cggcggggcc atcggccctt
     6661 ccgcgcggcc tccggtggga gcagcgtgga gggagggggc gaaggagagg agtgcccggt
     6721 ggacggctcg atggggctcg gccgcgtctt cggcataccg ctgaaggtgc actggagtgt
     6781 tccgctgctg ctggtggtgc tcggctacga cctgggccgg gaggtgctgc cgccctgggt
     6841 gcccggccgg tccggggccg tgtacgcggt tgcggggctg gtcggggccg tggtgctgct
     6901 ggccagcctg gtgctgcacg agggggcgca cgcggtggtc gcgcgccggg gcggggtcaa
     6961 ggtcgaggac atgacgctct gggcgctggg cggggtcacc aggatgggcc cgccgcagac
     7021 ccccagggcc atgctggccg tcgccgggag cgggccgctg accagcctgg tggtgggcgg
     7081 cgtcctgctg ggcgcgggcg tcggcctgca tgccgcgctg gggtggggcg tggtcccggc
     7141 gctgctggtc tggctgggcg cggccaatct gctgctgggc gtcttcaatc tgctgcccgc
     7201 cgccccgctg gacggcggcc gggtgctcca ggcgctgctg tggatgcgct ccggcgaccg
     7261 gctgcgcgcc gagcaggtgg cggaccagag cggccaggtg gtgggctatc tgctgatcgc
     7321 gctgggcgtg gtctcggtgc tcggcgggtc cgccggaggg ttctggctgg ccctgatcgg
     7381 cttctttgtg gcggtcacgg cgggtgcgga gcggcggcgc gcgatgctgg gcagcgccct
     7441 gcgcgggctg cgggtcgcgg acgccatgtc ggcgccggtg gagaccggcc cggactggca
     7501 gacggtggcc cgcttcgtgg acgacgccgt ggcgcgcagc caccactccg cgctgcccct
     7561 ggtggacttc gagggccgcc ccagcggcct ggtcaccctc cgacgactgg ccgccgtacc
     7621 gcccgcgcag cgcgagcagg tccgggtacg ggatgtggcg cagccgctgg cccgctgcgc
     7681 caccgccgaa cccggcgagg cgctggccga agccctccag cgggccgccc agcacggcgg
     7741 ctcccggctg ctggtggtgg acggcggtcg gctggtgggc atcgtcaccg gccatgacgt
     7801 cgcccgcctg atgcaccggc acgccctggt cgaccacccg ggccacgccg cctgacccgc
     7861 ggctgctgcc gcgcccgccg ccctggcacg cacatctgcc gcgttggcga gggcggcccg
     7921 ccgccttgca gctgcacgca ccgggacgcc tcgctaccgg gcagacgtcg gcgggcgagg
     7981 cgccggcggg cgaggcaccg gctctagccc tcggcggggc gcagccgcag cgagatgctg
     8041 ttgatgcagt accgctggtc ggtgggggtc ggatagccct cgccctcgaa gacatggccg
     8101 aggtgggagc cgcagtgcgc gcagcggacc tccacccggc gcatgccgag ggtggagtcc
     8161 tcgatgtact ccacccggtc ctcggccagc ggcgagtaga aggacggcca gccgcagtgg
     8221 ctctcgaact tggtaccgga ggtgaacagc tccgcgccgc aggcccggca ggagtagacg
     8281 cccacggtgg tggtgtcggt gtactcgccg gtgtgcgggc gctcggtgcc cgcctcgcgg
     8341 agcacgtggt actccgccgg ggacagctcc gcgcgccact cggcgtcgct cttctcgatc
     8401 cggtacttgc cggtctcctg ggccacggtg ggctcccttc ggtgcggccg aacgcgactg
     8461 cggtcagaca ccagcctcaa cgccggcgag gcgggccagg atttccgggc cgagtccggt
     8521 gacgtcgccc gcgcccatgg tgagcaccag atcgcccgcc ttggcgagcg ccgcgacggc
     8581 ctccggcacc tcggccatgg tgtgcaccgg gaccgtctcc agaccgtggc cgcgtgcggc
     8641 gtcgatgatg acctcgctgg tcacgccggg gatcgggtcc tcccgggcgg ggtagatgtc
     8701 cagcaccagg gcggcgtcgg ccagcgccag cgcctgcccc atctcggtgc ccaactgctg
     8761 ggtgcggctg aagagatgcg gctggaagac caccagcacc cggccgcccc cggcgctctg
     8821 ccggatcgcc tccagatcgg cggcgatctc ggtggggtgg tgcgcatagg agtcgatcac
     8881 ctggacgccc ccggcctcgc ccttgagctg gaggcggcgg cgcacccccc ggtagctgcc
     8941 cagggcggtg gccagctcct cggcgggcac gcccagcgcg atcccggcgg cgagcgcgga
     9001 gacggcgttg tgggcgtagt ggcggccggg caccgagacg gtgaaggtga gcggcgcccc
     9061 gtcggtaccg gccggttcca cggtgacctc gctggacatc ccgcgcggca ccaccgagag
     9121 gatccgcagc gaggcgtcgg ccgactcgcc gacggtgacg atccgcaggt cggggcggtc
     9181 cgagacccgg gaggtcagct cgcgggcgcc ggagtggtcg gcggagacga ccagggtgcc
     9241 gcccggctcg atgcggccca caaaggtctc gaaggactcg tggatctcct cgatggaggc
     9301 gtagttggcg tggtggtcca gctccacatt gagcacgatc gccacctcgg gcgcgtactt
     9361 gtggaaggag cggtcgctct cgtccgcctc ggcgacgaag atctcgccgc tgccgtggtg
     9421 ggcgttgctg cccggctcgt ccaggtcgcc gccgatggcg tacgaggggt ccaggcccag
     9481 ggcggccagg ctgaccgcga gcatgctggt ggtggtggtc ttgccgtggg taccggccac
     9541 cgccagcgcc cgccgcccgt gcatcagcgc ggccagcgca tcggcccggt ggatcactgg
     9601 caggccccgc tcgcgggccg cgaccagctc cgggttgtcc tcccggatcg cgctggagac
     9661 cacgacgcag ctcgccgtct ccggcacctg cccggcggcg tgcccgatgg cgacctcggc
     9721 cccggccgcc cgcagcgccg ccgtggtggc cgactccctg gcgtcactgc cggagacctc
     9781 cgccccgcgc agggccagga tcttcgccag gccggacatg cccgcgccgc cgataccgat
     9841 gaagtgcggg gcgtgcaggt cgctcggggc gtcgctcacg ggggtactcc cggggtggtg
     9901 ggctgctgct ctgtggtgcg tcgtacggcg cggggaggcc gcagccgcaa ggacgattct
     9961 gcaccacggg gaggcggccc ccgccacgac ccacgcccgg ggcggggcgg gtgtcagacg
    10021 tcgtgcgcga agagcttgag gaccggcacg cccacccggt ggcgggcccg cgacgcccag
    10081 tcgcggtgga agaactcctc gacgaagtgc ggggaggtga gcacgatgac ctcgtcggcc
    10141 ccggtgtcct ccaccacggt gcgcagcatg cccagcgggt tgtcggacac cacatggccg
    10201 acggcgtccg aaccggcggc gtgcagccgg tccagggtgt gcgccagcgc ctggtcggca
    10261 ggggtggcgg tgtcgtcctc gtcccgctcg tgcaccgcct cctccaggcg gccgagcgcc
    10321 acgtcgtcca gggcgcgcag cagttcgtcc tgccggccgc gcggctgcat caggacgaca
    10381 aaggaggtct tctcctcgcc gtgcagcgtg gtgaccagct cgatgtcggc ctcggagagc
    10441 gccttctcga tcatcagtac ggtcgtgaac acgtgagtcc cttcttctcc ccgtggcccc
    10501 cggtccctgc ctgctcccat actgccctcc cgccccgggg gccacgcagg gaacggggtg
    10561 tgccgcagcg ttgcggtggt cacaccgggc gggcgtagcg ggcgaagagg aaaccatcct
    10621 cctccagcag tgagcagagc cggaaccgct ctgccgccgc cggttccgga ccgtgcagga
    10681 tgcgcggcgc gtcgcccacc gcgagcagcg gcgccagcgt caggcagagc tcgtccagca
    10741 gccccgccga ggccagctga cccagcagcc ggggaccgcc ctcggtgagc agcctggtcc
    10801 agccccggtc ggcgagcgcg cgcaccgccg ccgccatgtc cacccgctcc tccccggcca
    10861 ccaccaggtc ggcgacctcg gcggcggccc gccgggccgc ggccggggcg ctctcggcgg
    10921 tgatcaccac cgtgggcagc agcggctcgg tgaagagcgg ggtcgagagg tccaggtcca
    10981 gactgcggct gaccacggcg atggccggcg cgggcgcctg gccgcgcgcc gcccggtccg
    11041 ccgcgaacgc ctcccgggcc cgcgccgggc ggtacccctc gctgcgcacc gtctccgcgc
    11101 ccaccagcac cacgtccgac agcccccgca gcaccccgaa gacgcgcttg tcggcggcgc
    11161 ccgacagacc ctcggagtgg ccgtcgacgc gggccgcgcc gtccagcgat gccaccatgt
    11221 tggcgcgcag ccaggggcgg ccccggtcgg cctcggcggg gtaggcgtag acggcggcca
    11281 ggccctccag ggtgtccggc cccggggtgg tggcgtgggc ggcggggtcg gcggggtcgg
    11341 cagggtcggc ggggagaaga cggcgc
//
