LOCUS       NZ_CP031264            25199 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Peterkaempfera bronchialis strain DSM 106435 chromosome, complete
            genome.
ACCESSION   NZ_CP031264
VERSION     NZ_CP031264.1
KEYWORDS    RefSeq.
SOURCE      Peterkaempfera bronchialis
  ORGANISM  Peterkaempfera bronchialis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Peterkaempfera.
REFERENCE   1  (bases 1 to 7090212)
  AUTHORS   Nouioui,I., Klenk,H.P., Igual,J.M., Gulvik,C.A., Lasker,B.A. and
            McQuiston,J.R.
  TITLE     Streptacidiphilus bronchialis sp. nov., a ciprofloxacin-resistant
            bacterium from a human clinical specimen; reclassification of
            Streptomyces griseoplanus as Streptacidiphilus griseoplanus comb.
            nov. and emended description of the genus Streptacidiphilus
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 1047-1056 (2019)
   PUBMED   30741626
REFERENCE   2  (bases 1 to 7090212)
  AUTHORS   Batra,D. and Gulvik,C.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUL-2018) Bacterial Special Pathogens Branch, Centers
            for Disease Control, 1600 Clifton Road, Atlanta, GA 30329, USA
REFERENCE   3  (bases 1 to 7090212)
  AUTHORS   Gulvik,C.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2018) Bacterial Special Pathogens Branch, Centers
            for Disease Control, 1600 Clifton Road, Atlanta, GA 30329, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2018
            Assembly Method                   :: HGAP v. 3; Pilon v. 1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 176.4x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003258605.2-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:52:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,114
            CDSs (total)                      :: 6,019
            Genes (coding)                    :: 5,833
            CDSs (with protein)               :: 5,833
            Genes (RNA)                       :: 95
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 186
            CDSs (without protein)            :: 186
            Pseudo Genes (ambiguous residues) :: 0 of 186
            Pseudo Genes (frameshifted)       :: 60 of 186
            Pseudo Genes (incomplete)         :: 147 of 186
            Pseudo Genes (internal stop)      :: 2 of 186
            Pseudo Genes (multiple problems)  :: 22 of 186
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:20:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3972236
            Orig. end                         :: 3997435
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031264.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25199
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="13"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25199
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25199
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15199](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15199
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    441..458
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     gene            1008..2138
                     /gene="ccsB"
                     /locus_tag="C7M71_RS17680"
                     /old_locus_tag="C7M71_017680"
     CDS             1008..2138
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_process="GO:0017004 - cytochrome complex assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ccsB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328492.1"
                     /locus_tag="C7M71_RS17680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017680"
                     /product="c-type cytochrome biogenesis protein CcsB"
                     /protein_id="WP_111489463.1"
                     /transl_table=11
                     /translation="MVLATAVNENLANISNYLIYSAMAVYLLAMLAHCFEWTFGSRGAV
                     ARRSAEQGGSLAEAAAAARPGARKVTVTMASADGGTATLTRTALADAGDVVVTSGRGDD
                     ETDGPGAAGTDQQADLLGRMAVSLTVLGGLLHAAGVLTRGLSVMRWPWGNMYEFSCAFA
                     LAAVAAYLVLLALGKKVRWLGLPVVLAALLTLGLAVTVLYTDSEQLVPALHSYWLAIHV
                     SGAIICSGAMYAAFVATALYLLKDAYDKRVAAGRTTGPLGTPASVWQRLPAASTLDKLA
                     YRINAVVFPFWTFTIIAGAIWAEDAWGKYWEWDPKETWAFITWVAYAAYLHARATAGWK
                     GRKAAYLALLAFACFLFNYYGVNIFVTGKHSYAGVG"
     gene            complement(2225..2419)
                     /locus_tag="C7M71_RS17685"
                     /old_locus_tag="C7M71_017685"
     CDS             complement(2225..2419)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145079.1"
                     /locus_tag="C7M71_RS17685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017685"
                     /product="acyl-CoA carboxylase subunit epsilon"
                     /protein_id="WP_111489464.1"
                     /transl_table=11
                     /translation="MIQVVKGSLTDEELAAVTAVLLARAAATAAARQSSAAQPEPVARW
                     QRLERRPSYYSPLSWQTAA"
     gene            complement(2436..4043)
                     /locus_tag="C7M71_RS17690"
                     /old_locus_tag="C7M71_017690"
     CDS             complement(2436..4043)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136439.1"
                     /locus_tag="C7M71_RS17690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017690"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_111489465.1"
                     /transl_table=11
                     /translation="MTVLQEASTEEADQAPPAPVDTRGRVAELRDLKDRARSGPSERAT
                     EAQHAKGKLTARERIALLLDEDSFSEVEPLRRHRATGFGLEAKKPHTDGVVTGWGTVHG
                     RTVFVYAHDFRIFGGALGEAHAQKIHKIMDMAIAAGAPLVSLNDGAGARIQEGVTALAG
                     YGGIFQRNTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVKAV
                     TGEQISQNGLGGADVHAEVSGVAHFAYDDEQTCLEEVRYLLSLLPQNNRETPPAVPTDD
                     PVDRRCEALLDLVPADGNRPYDMRKVIEELVDDGQFMEVHERWATNVICALARMDGQVV
                     GLIANQPQSLAGVLDIEASEKSARFVQMCDAFNIPLLTLLDVPGFLPGVDQEHGGIIRH
                     GAKLLYAYCNATVPRIQLILRKAYGGAYIVMDSRSVGADLSYAWPTNEIAVMGAEGAAN
                     VIFRRQIAAADDPEAMRVRMVKEYKSELMHPYYAAERGLVDDVIDPAETRAVLIRSLAM
                     LRTKHADLPSRKHGNPPM"
     misc_feature    complement(4438..4453)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.74"
                     /tool="antismash"
     misc_feature    4439..4452
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.41"
                     /tool="antismash"
     gene            complement(4491..5441)
                     /locus_tag="C7M71_RS17695"
                     /old_locus_tag="C7M71_017695"
     CDS             complement(4491..5441)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS17695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C7M71_017695"
                     /product="phosphotransferase"
                     /protein_id="WP_162824290.1"
                     /sec_met_domain="APH (E-value: 5.7e-11, bitscore: 41.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSDPAVRTSVRPRWAQLAPEARESVTAVLGSSVARSLPQAGGF
                     SPGLAVRATLADGRPVFLKGIATDHAAYSMYATEAAVNRALPAQVPVPRLLDAWEAGGW
                     LLMAFEDVGGGHPDLAPGSPDLGAVLHLLDRLPQTVSPSPIPDAPAVADVLQGGFHGWR
                     TLADQHAALDTWSARHLGKLAAIERDWRADSTGDCLLHVDLRADNMLMRDGNALAIDWA
                     YLHQGAPWIDPAFLVPQLIRAGHSPARAEELMADVASWNGAPPEAVTSFAAAQAGYWER
                     SSRLPAPPGVPHLRGYQAEMAAIGRTWIAHRTGWR"
     gene            complement(5599..6093)
                     /locus_tag="C7M71_RS17700"
                     /old_locus_tag="C7M71_017700"
     CDS             complement(5599..6093)
                     /EC_number="2.3.2.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017868.5"
                     /locus_tag="C7M71_RS17700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017700"
                     /product="gamma-glutamylcyclotransferase family protein"
                     /protein_id="WP_111489467.1"
                     /transl_table=11
                     /translation="MTEPINQEARGPVTPARRNRLADGPEALFVYGTLQFDAVLEALLG
                     RVPPRTPASAQGWRAAALEERVYPGLVAAPNATTLGLLLTDLSTEEWAILDAFEDDRYD
                     LRKVPLTSGDSGWAYIWADGDIRAEDWNADDFAARHLQQYAARCARISAELAKGAIDAI
                     K"
     gene            complement(6108..6656)
                     /locus_tag="C7M71_RS17705"
                     /old_locus_tag="C7M71_017705"
     CDS             complement(6108..6656)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="C7M71_RS17705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017705"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_162824291.1"
                     /transl_table=11
                     /translation="MDVEYQRYDGPSAKGIADELVEVYSKVYDVPPYIGDPFFSDQAFR
                     DRLEAAFDSEGFETLTARLNGRIVGYVHGATLPADKPWWISLGDRRPETLREMAEAGQV
                     FWLRELMVLPECTNHGLGRRIHDTVITGRAEGVTALTCIVGNQPAHDAYLRWGYTVVGR
                     IKHAPESPVYDAMFLPSTR"
     gene            complement(6683..7996)
                     /locus_tag="C7M71_RS17710"
                     /old_locus_tag="C7M71_017710"
     CDS             complement(6683..7996)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS17710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C7M71_017710"
                     /product="hypothetical protein"
                     /protein_id="WP_111489469.1"
                     /transl_table=11
                     /translation="MSEMKRLRESLNRTQEQVVRELSALAARLSAEGRIGKAPTFSVRQ
                     YSKWEAENPPSPHPDTRQVLSVYWQRPIEELGFRPRGGGSSLPAVMPMPPITRSAAAVV
                     PFFGARSTAPMSDQPPPWLAETTTGATSSADWRIGASEVELLREAADDMDAIDQQFGGN
                     RLWRPTRAHLHWVHHMIDRGIYDDTLGRQLHAVAGKFTTSLGWFCYDAGLQAKAHQYFS
                     EALNAAMLTGDDMLACRTLSNLARQAVDLNKGREAVRFARLAHAHAGEWQAPNRVIALL
                     AIREAQGYARIGDRFSSEAAIRQAWAEWERGDDVRDPDWTTFLNMAELTCLEGMCRLDL
                     GQTARAQKLLSKSEALQDVAHSRNRGMCLGRLSVAALHNGDIDHSIAATTKALRLIEGG
                     MSSNRAVEQLKIVRDGLAPHHRSSGVADLLEQIRAYGA"
     misc_feature    complement(7976..7978)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8173..8183)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            8437..9678
                     /gene="fxlM"
                     /locus_tag="C7M71_RS17715"
                     /old_locus_tag="C7M71_017715"
     CDS             8437..9678
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009329291.1"
                     /locus_tag="C7M71_RS17715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017715"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_111489470.1"
                     /sec_met_domain="PCMT (E-value: 5.9e-41, bitscore: 139.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNGPDMMTEANSSANEDQLRDQMIRRLIELGALRSRQVVAAFRK
                     VPRHLATPDEDMATVYSVERAVITKTDADGVQLSSVSAPRIQAMQIEQADIHPGMQVLE
                     IGSGGVNAAYLAEIVGKDGLVVTADIDSEVTERASVFLSQAGYDQVHIVTVDGENGVPE
                     HAPYDRILVTVQAADIPPAWLDQLKDGGRLVVPLRVRGMTRTVAFVRHGDRLLSDGFEL
                     CGFVPMQGIGENRVRLVLLHEVSGEEVGLRLDGHPEPDVEALSAALHTPPVKSWSGVAL
                     AGDESNEHLDLWLTTALDNLPLLAGQQAARARGIVASISPHGIPTLVEADSFAYRTVRP
                     TDDPDRFELGAIGHGPHAQEVADRLVEQIRVWDRVHRSHRAHIEVYPAGTPDDVLPAGR
                     VIDRPHTRITITWP"
     gene            9735..9923
                     /locus_tag="C7M71_RS17720"
                     /old_locus_tag="C7M71_017720"
     CDS             9735..9923
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="C7M71_RS17720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017720"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_111489471.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3e-13, bitscore:
                     47.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPQSSTLKAATDFSGEGMSDFDLSIETVASAPIVPGLLNDTGDG
                     CGSTCQSACSNSTCISG"
     CDS_motif       9735..9845
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAPQSSTLKAATDFSGEGMSDFDLSIETVASAPIVPG"
                     /locus_tag="C7M71_RS17720_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9846..9923
                     /prepeptide="core"
                     /locus_tag="C7M71_RS17720_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-7.70"
                     /molecular_weight="2250.4"
                     /monoisotopic_mass="2248.9"
                     /core_sequence="LLNDTGDGCGSTCQSACSNSTCISG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAPQSSTLKAATDFSGEGMSDFDLSIETVASAPIVPG"
                     /leader_location="[9734:9845](+)"
                     /alternative_weights="2268.4"
                     /alternative_weights="2286.4"
                     /alternative_weights="2304.5"
                     /alternative_weights="2322.5"
     gene            10001..13045
                     /locus_tag="C7M71_RS17725"
                     /old_locus_tag="C7M71_017725"
     CDS             10001..13045
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319705.1"
                     /locus_tag="C7M71_RS17725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017725"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_111489472.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.6e-189,
                     bitscore: 627.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.7e-18,
                     bitscore: 64.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.3e-35, bitscore:
                     120.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYHAVDAALIRASARPLAAELPPWPNLDGSSPDDVEGWREWIGQV
                     WATDATAEAITFASPVLAEAVRGVLTGRLRQPRATLRATLSLMRYLLRMQYRPTPFGLF
                     AGTAPVRLGRTAKVHRGTDHRGSARPDAEWLAEVASDLETRSALLRRLPVMADPTRIVR
                     GAKVVVPHQPGADGPVEMSMRHTPAVEVVLSLAHSPITAGEIVAELQADYPDMPVAAIE
                     DMVRRLVKHGLLLTSLRAPMTTDDALGHLISQLDILGAGTVSETGGIPGQLRRIHQLLT
                     RHDAAPADEQRTIRAEAAHRMTAVTEVTERTLIVNLRPDCDTVLPLVVAEEAQRVLAVM
                     ARISPYPAGPPAWQDYRARFLERYSMGALVPVRDLTDPDIGLGVPAGYRGSVLKRPVLA
                     TSRRDEYLLALAQDAAANRTREVVLAEEDVASLSVGDFVQVPAHVELCFTVLARSLGDL
                     RQGRFALDLVGLSSAAGTTTGRFLAMLEQPDRDRMSAVYAGLPTLEDGAVRAQISSPPL
                     RLRTQNVSRSPAVVPHVLSLGEYNPTANLDLDDLAVGADARRLFLASLTTGQRIEPSVM
                     NAVELTNATHPLVRFLSEVHRSHVAVMAPFSWGAAARLPFLPQVRVGRTILSRACWRLT
                     RRHVGTAAGADWMRRFTDWRCRYGVTRTVFVGSDDQRLRLDLDHPAHLRILRSELEHAS
                     VLTLHEAPEEDAFGWLGHAHEITMPFASDLPPARRIDATAVVRREVGRLPGTTPWAYLK
                     VYSHPDRASEILATCLPALLDQWGDETPQWWFTRYGDPGTHLRVRIRLARPDAFGEVAQ
                     RVGAWAAALRNDGLASRIQWDTDEPEIGRYGTGHALDAAERYFTADSAAAIAQMALQIP
                     SGLRQAVTAAGFVDIADAFTGGPAAGRRWLVENLLKSQGVAPPRDVQAHALRLAAPDTG
                     LAALRSLPGGEGVIAAWTHRRQALGQYRASLEDAGAAPAAVLPSLLHMHHNRAAGVDTD
                     DEVTCCRLARTAALSWTVRQKGALR"
     aSDomain        10460..10723
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C7M71_RS17725_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.20E-20"
                     /identifier="RREFam001.1"
                     /label="C7M71_RS17725"
                     /locus_tag="C7M71_RS17725"
                     /protein_end="241"
                     /protein_start="153"
                     /score="64.1"
                     /tool="antismash"
                     /translation="VMADPTRIVRGAKVVVPHQPGADGPVEMSMRHTPAVEVVLSLAHS
                     PITAGEIVAELQADYPDMPVAAIEDMVRRLVKHGLLLTSLRAP"
     gene            13045..14190
                     /locus_tag="C7M71_RS17730"
                     /old_locus_tag="C7M71_017730"
     CDS             13045..14190
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447324.1"
                     /locus_tag="C7M71_RS17730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017730"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_111489473.1"
                     /sec_met_domain="LANC_like (E-value: 9.2e-42, bitscore:
                     141.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPSALDPATATRQSLAHGPLGMALLHVERARCGNGPWEAVHRR
                     LAVIGPLIEGPEASLFLGAPAMAYVLHLAAADSNRYAGALHALDGIVAAHTRRRLDTAH
                     DRIDKSRQAAFAEYDLLRGLTGLGVLLLRRQPDSVETKRVLEYLVRLTEPIKGPKGIRI
                     PGWWVWHAPTNLGAPTPGGHANVGLAHGIAGPLALLALAKRKGVVVDGQDDAMMRICRW
                     LDRIRQSDHRGTRWPRWVTEAAVVPVRPAAPSWCYGTPGLARAQQLAGIAMEDDHRKRM
                     AERALLDCLADPLQLNRLTDRGLCHGVGGLLRTVERVAEDAETPSVFTDRLHQLRQHSL
                     TMGPPEETGFLEGAAGAALAFQCAEPDAGGVGDWDACLLLV"
     gene            14219..15199
                     /locus_tag="C7M71_RS17735"
                     /old_locus_tag="C7M71_017735"
     CDS             14219..15199
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319709.1"
                     /locus_tag="C7M71_RS17735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017735"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_111489474.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.4e-33, bitscore:
                     113.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLHDSCAAEQAVLSVLAGTSIEDTAARLRTSPTRLAEAVELYRA
                     AGRAALDAQPLPSGWHQTYIEYTDYLAADRAFRAHLLPCLRDGVGTGLVGGWWFLRKRP
                     CWRLRVQPGPGVIVEDVIEHITDALDSTVSSGLAKRWWPSLYEPETVAFGGPDGMEIGH
                     TLFHDDSVGVLDYLQRMNTDPAGLLDAKATSFLVITLFLRAAGQEWAEQGDVWARIETT
                     RPLPAEEAPAEKIVVMADTLRRLLMLDAGAALAVEGPLASLSAWTAGMERGGRALADAG
                     REGRLSLGLRSILARHVLFHWNRMGFTSRQQAIWARVARQAILGC"
     gene            complement(15384..15836)
                     /locus_tag="C7M71_RS17740"
                     /old_locus_tag="C7M71_017740"
     CDS             complement(15384..15836)
                     /EC_number="3.5.4.33"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0052717 - tRNA-specific adenosine-34
                     deaminase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007490879.1"
                     /locus_tag="C7M71_RS17740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017740"
                     /product="nucleoside deaminase"
                     /protein_id="WP_175607702.1"
                     /transl_table=11
                     /translation="MDDGTAARAMLAVAMEEARAGLAEGGIPIGAALFGPDGELLGRGR
                     NRRVQDGDPSMHAETAAFRAAGRLRGYGRTTMVTTLSPCWYCSGLVRQFGIGRVVVGEA
                     VTFSGGHGRLAEHGVSVTVLDDPECVALMRDFIAARPDLWAEDIGE"
     gene            complement(15923..16144)
                     /locus_tag="C7M71_RS30730"
     CDS             complement(15923..16144)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS30730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162824292.1"
                     /transl_table=11
                     /translation="MRRFLTVVPILGCWIGFQHAARGGSGGATSAKTTGIGLFREEEAP
                     GLVMPQGYKDSIGTWYAHLRTVSAQGRN"
     gene            16143..16334
                     /locus_tag="C7M71_RS33240"
                     /old_locus_tag="C7M71_017745"
                     /pseudo=""
     CDS             16143..16334
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477382.1"
                     /locus_tag="C7M71_RS33240"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017745"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLGTTSDKNEYPTL"
     gene            16339..16872
                     /locus_tag="C7M71_RS17750"
                     /old_locus_tag="C7M71_017750"
     CDS             16339..16872
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385213.1"
                     /locus_tag="C7M71_RS17750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017750"
                     /product="DUF6879 family protein"
                     /protein_id="WP_111489476.1"
                     /transl_table=11
                     /translation="MTELASTAVLNDLFDTFQHTAWRLEVRRAYDADQRTDLYKRFLRG
                     EGVEEDTSGPWYTSRRQMAAEGKRVERVRLVDAPLTENQRFLLARAPHIIGVGEDVRYL
                     WRTDAEKLGLPMEDVWLFDSRLAARLHFDGDRTAGVELIEEPAEVLAYCQARDAAWHFA
                     VPYAGFRARVPSPE"
     misc_feature    complement(16378..16391)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.67"
                     /tool="antismash"
     gene            complement(16833..16982)
                     /locus_tag="C7M71_RS32930"
                     /old_locus_tag="C7M71_017755"
     CDS             complement(16833..16982)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="C7M71_RS32930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017755"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_111489477.1"
                     /transl_table=11
                     /translation="MSTFPDLSTTTWVKSSYSNGNEGECIEVAPGPLVVGTHSGEGTRA
                     LKPA"
     gene            complement(17044..17244)
                     /locus_tag="C7M71_RS17760"
                     /old_locus_tag="C7M71_017760"
     CDS             complement(17044..17244)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014054570.1"
                     /locus_tag="C7M71_RS17760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017760"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_111489478.1"
                     /transl_table=11
                     /translation="MSTTPLWTKSSHSGGNEGQCIEVALNLPDTVPVRDSKDPNGPTLT
                     FTPAAFTAFITAATTGEFDTA"
     gene            complement(17334..17546)
                     /locus_tag="C7M71_RS17765"
                     /old_locus_tag="C7M71_017765"
     CDS             complement(17334..17546)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018385106.1"
                     /locus_tag="C7M71_RS17765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017765"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_111489479.1"
                     /transl_table=11
                     /translation="MNVPDLTLTRWVKSSYSGGNEGECIEVAPGLPGIVPVRDSKDPHG
                     PALIFTADAFAAFVTATAAGEFGTV"
     gene            complement(17543..18376)
                     /locus_tag="C7M71_RS17770"
                     /old_locus_tag="C7M71_017770"
     CDS             complement(17543..18376)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009714882.1"
                     /locus_tag="C7M71_RS17770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017770"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_111489480.1"
                     /transl_table=11
                     /translation="MSESTTGRAGRGRASGAEILGAEVRAWRLHAGLSQRELGEKAQYG
                     QQYVAKVESGERLASPEFCRACDQIFGSPESFARLRERATQSGYPDWFIPYLQLERQAT
                     SILNYSVALVMGMLQTEDYATAVFRASHPRDGVDEIKARVARRLKRRVIMERSAPPLLW
                     CVLDESCLRREVGGRHVMHDQLSRLVKDAQSPHITLQVLPWSSGAPSTHLGFTLLKFAE
                     DPDLLYVENPLSGQVIDSPAVVADAAVTYDRLRADALSPEASLVLMRKVMEEYTP"
     misc_feature    complement(18400..18410)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            18884..19504
                     /locus_tag="C7M71_RS17780"
                     /old_locus_tag="C7M71_017780"
     CDS             18884..19504
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003954880.1"
                     /locus_tag="C7M71_RS17780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017780"
                     /product="hypothetical protein"
                     /protein_id="WP_114914416.1"
                     /transl_table=11
                     /translation="MTASKRPGTVPYIASWSGEKRCTGAVVEDRRSPGRIAYRDERPDD
                     RDEYGVLWARADSRPTRGRPQYGLVHPRRQRHAMRNLRCQVCDGPADTDERGTLWLLGD
                     DRGDWPGWPEEMAATTPPLCLPCARLSVRLCPHLRGRHIAVRVRNPEIAGVYGALYLPR
                     PDRARPTAATDTTIAYTDPAVCRVLAAQQVMRLRGCTLVDLPG"
     gene            19719..20420
                     /locus_tag="C7M71_RS17785"
                     /old_locus_tag="C7M71_017785"
     CDS             19719..20420
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="C7M71_RS17785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017785"
                     /product="response regulator transcription factor"
                     /protein_id="WP_162824293.1"
                     /transl_table=11
                     /translation="MGPDGNDEAIPVIRVAAVDDHPILLDGIGAHFARHAPDIRLVATA
                     EDVGALLAEDTGDGAALVVLLDLRLRDGSDIGSNVRRLRATGARVLVFTGEQRPALVRR
                     ALDAGALGLVLKEDPQDRLVEAIRTADTGEMYVSSRLAHSIVTDPRGSVRLSAQQSRVL
                     ELIARGLPHADIARMLHITEDTLHTHRKRAISAYAKAGDELVGGTGELVYRAVADGHID
                     IGPDLPERAGP"
     gene            20489..20950
                     /locus_tag="C7M71_RS17790"
                     /old_locus_tag="C7M71_017790"
     CDS             20489..20950
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS17790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C7M71_017790"
                     /product="hypothetical protein"
                     /protein_id="WP_162824294.1"
                     /transl_table=11
                     /translation="METGLSYAVAALSGLFALSWSMFLVSGGPERAPDVRAVAAVFLVQ
                     AVVTAVRGVRVRLSRADSGVALALAVLGHAVLAVGGASRVVIGQRCLLASPAVLLAVGF
                     LPRRAGRWACLAAIGAQVATGWPADGPAGAVEGVWPVVATAVAGDVLVP"
     gene            20950..22791
                     /locus_tag="C7M71_RS17795"
                     /old_locus_tag="C7M71_017795"
     CDS             20950..22791
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="C7M71_RS17795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017795"
                     /product="ATP-binding protein"
                     /protein_id="WP_114914418.1"
                     /transl_table=11
                     /translation="MRAAGARADLAQRRVRAARAAAGRAEGRREAHRRFQGMLHDEVST
                     ALQAISLPGVPVARLREAASGAVAALAAAPAGPGRKARTDLAAVVRALRPPPGTVLAIE
                     ATGPALVPPEVADAAAGAAREALRNVEEHAGARSVRLRLRGGPPDRPGAAADGEFTLSI
                     TDDGVGFAAGELAASSVGLRRSVIRRMAAVGGHAEVRSAPGHGTTVRLEWRPPAAGPAA
                     DEADEAETGAGTVGGPAGGPTGVPADTLGRMRAAVGDVRRPLAAVCLPFLTAMGVIAAI
                     HTARTPGTGPLLVWYALLTALTVALLLRAASGIPALVAGAACAFAVAGALGSFLVLPLA
                     SLADYTSWPVGAVTPLLTLLVIVRPAWEALTALALEQVGIAVLVATGPPIAPSVGATMA
                     LLLPALLSPALGVITGLALGRTVARLGGVTARAEADRSASLATEAARRAREELHQGRLA
                     DLGQEILPFLAATGSGRCAPDDPGVRDRARLLAGAVRDEIHLPGVLDRTVRELLSAARR
                     AGCVVTIQSDSDDPHPPAFLRLLLTTALTCAPTPRELVLTVNAAAGVARASLVVLPGDE
                     WRARALREAVAGAGAGTGVVVADSATSTWVEADVRAS"
     gene            22949..23962
                     /locus_tag="C7M71_RS17800"
                     /old_locus_tag="C7M71_017800"
     CDS             22949..23962
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014036.5"
                     /locus_tag="C7M71_RS17800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_017800"
                     /product="GTPase family protein"
                     /protein_id="WP_162824295.1"
                     /transl_table=11
                     /translation="MSESIRDRLRRFTTSVERSDDLSPAQRAGILQGYEEALGNEGPPR
                     LVLIGESGVGKSTTVNALFNAGQAVGHSRATTDRAWSIPVQQVSGSNGTLEVVDMPGLG
                     DDIANYPRYMGLYREVLPTADAIVWIHPAKDRMVQLVQQALADLFGPSPELVGRLVFGL
                     NKADEIGPHDWNAPANLPSELQWAALREREEDFTRSISRVLPTWRGRAVSYAALRFYNL
                     TALFKEMMYAVPEQRRWVLEQRMDLADFTALVDRKLLRAATARTLVEVPAGEPEPEPAP
                     APPQPVRQRREQPTTHPPRSVADALAALSDAQWRDLHADRARFEEFVRRLEQGSAR"
     misc_feature    complement(22950..22964)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            23959..24267
                     /locus_tag="C7M71_RS17805"
                     /old_locus_tag="C7M71_017805"
     CDS             23959..24267
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS17805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C7M71_017805"
                     /product="hypothetical protein"
                     /protein_id="WP_111492328.1"
                     /transl_table=11
                     /translation="MNAEPGPDPGADLDSLVDALRMVMREQEENLREIGRMSEVSFRLW
                     LGSVANRLAAAVGIPLARVHAFLGDLASIVVDAGATLKRSYRDEYRRARRYPRAPAN"
     gene            24471..24731
                     /locus_tag="C7M71_RS30735"
     CDS             24471..24731
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS30735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_162824296.1"
                     /transl_table=11
                     /translation="MWETRFHCACGHRFEAQEVEEAVREIIRVASLLAQVLAQQAKDLA
                     EIRRAGEVSFRAWVSRFADAVASSLGALAGRLVGRLLRALD"
ORIGIN
        1 accaagggcg accagctggg caccccacgg gacttcgccg cccatgtccg gtactggacc
       61 ggcgccgacg gcggcagctc gcaccgggcc gccatcaagg tgaaccagcc gctggagatc
      121 gccgacagca aggtctacct ggtcagccat ggctactcac cggtcgtcac ggtgaagaac
      181 gccaagggcg aggtggtctt ccacggcccc accccgttcc tgccgcagga caacaacctc
      241 acctccatcg gcgccatcaa ggtcggcgac tacggccaga aggacggcaa gccggtgcag
      301 ctgggcttcg ccggcatctt ctcgcccacc gccccggtca ccgcggacaa ggtgacgggc
      361 tggaactcgc tcttccccgc cgccgccgac cccaagctga tcctcaatgt gtgggccggt
      421 gacctgggtg tggactcggg catcccgcag agcgtgtacc agctcgacga gacccatatg
      481 aagcagctca agcaggacgg cgacatcgcc agggcggcgc tcaagccggg ccaggggtgg
      541 accctgccga acggctacgg gaccctcacc ttcgacggcg tcgagcagtg ggccggcttc
      601 accatcgccc accgccccgg caacggcgtg gcgctcggca gctcggtgct ctgcgtactg
      661 ggcctgatcg gctcgctgct gatccagcgc cgccgggtgt gggtgcgggc caccaccgcg
      721 accgacggca ccaccgtggt ggagatggcc gggctggccc gcagcgagtc cgccaagatc
      781 gccgaggagc tggccgacct cgccgtcgcc ctccaggacg acgccccggc ccggcccgac
      841 gagccggatg aggccgacaa gccggacgag gctgagaagc cggacgaggc cgacaagccg
      901 gaccaggccg aggaccaggc cgagcggccg gaccaggccg aggagccgcc ctccggcggc
      961 gccgaccgta ccgaggagcc cgagatgatc gagaagaggg gttgacggtg gtccttgcca
     1021 cggcggtcaa cgagaacctg gccaacatct ccaactacct gatctactcg gcgatggccg
     1081 tgtacctgct ggcgatgctc gcccactgct tcgagtggac cttcggcagc cgaggcgcgg
     1141 tcgcccggcg ctccgccgag cagggcggct ccctcgccga ggcggcagcc gccgcccggc
     1201 ccggcgcccg gaaggtcacc gtcaccatgg cctccgccga cggcggcacc gccaccctca
     1261 cccgcaccgc cctggccgac gccggcgatg tggtggtcac cagcggccgg ggcgacgacg
     1321 agaccgacgg ccccggcgcg gccggcaccg accagcaggc cgacctgctc ggccggatgg
     1381 cggtctcgct caccgtgctc ggcggactgc tgcacgccgc cggggtgctc acccggggcc
     1441 tctcggtgat gcgctggccg tgggggaaca tgtacgagtt ctcctgcgcc ttcgcgctgg
     1501 ccgcagtggc cgcctacctg gtgctgctgg cactcggcaa gaaggtccgc tggctgggcc
     1561 tgccggtggt gctcgccgcc ctgctgacgc tcggcctggc cgtgacggtc ctctacaccg
     1621 actccgagca gctcgtcccg gcgctgcact cctactggct ggccatccat gtctccgggg
     1681 cgatcatctg tagcggcgcc atgtacgccg cctttgtcgc caccgcgctc tacctgctca
     1741 aggacgccta cgacaagcgc gtcgcagccg gccgcaccac cggcccgctc ggtacgccgg
     1801 cctccgtctg gcagcggctg cccgccgcca gcaccctcga caagctggcc taccggatca
     1861 acgcggtggt cttcccgttc tggaccttca ccatcatcgc gggcgcgatc tgggccgagg
     1921 acgcctgggg caagtactgg gagtgggacc ccaaggagac ctgggcgttc atcacctggg
     1981 tcgcctacgc cgcctatctg cacgcccgcg ccaccgccgg gtggaagggc cgcaaggccg
     2041 cctatctggc gctgctcgcc ttcgcctgct tcctcttcaa ctactacggg gtcaatatct
     2101 tcgtcaccgg caagcactcc tacgccggcg tcggctgacc ggccgcccgc ccctttgcac
     2161 gccgacggcc cggcccccct cttgccgagg gggccgggcc gttccggttc ctgctgtccg
     2221 cgcgtcaggc ggcggtctgc cagctgagcg gcgagtagta cgacgggcgg cgctccagcc
     2281 gctgccagcg ggcgaccggc tcgggctggg cggccgacga ctgccgggcg gcagcggtgg
     2341 cggcggcgcg ggcgaggagg accgcggtaa cggcggccag ctcctcgtcg gtgaggctgc
     2401 ccttgacgac ctggatcatc tctggactcc ttgggtcaca tgggcgggtt gccgtgcttg
     2461 cgcgacggca gatccgcgtg cttggtacgg agcatggcaa gcgagcggat gagcaccgct
     2521 cgggtttcgg ccgggtcgat gacgtcgtcc accaggccgc gttcggcggc gtagtagggg
     2581 tgcatcagct cggacttgta ctccttgacc atgcggaccc gcatggcctc ggggtcgtcg
     2641 gcggcggcga tctgccggcg gaagatgacg ttggcggcgc cctcggcgcc catcacggcg
     2701 atctcattgg tgggccaggc gtaggagagg tcggcgccca ccgagcggga gtccatcacg
     2761 atgtaggcgc cgccataggc cttgcgcagg atcagctgga tgcgcggcac ggtggcgttg
     2821 cagtacgcgt agagcagctt ggcgccgtgc cggatgatgc cgccgtgctc ctggtcgacg
     2881 ccgggcagga agccgggcac gtccagcagg gtgagcagcg ggatgttgaa ggcatcgcac
     2941 atctggacga agcgggccga cttctcggac gcctcaatgt ccaggacccc ggcgagggac
     3001 tgcggctggt tggcgatcag gccgaccacc tggccgtcca tccgggccag ggcgcagatg
     3061 acgttggtgg cccagcgctc gtggacctcc atgaactggc cgtcgtcgac cagttcctcg
     3121 atcaccttgc gcatgtcgta cggccggttg ccgtcggccg ggaccaggtc cagcagggcc
     3181 tcgcagcggc ggtccaccgg gtcgtcggtg ggcaccgccg ggggagtctc gcggttgttc
     3241 tgcgggagga gcgagaggag gtagcggacc tcctccaggc aggtctgctc gtcgtcgtag
     3301 gcgaagtgcg ccacgccgga gacctcggcg tgcacatccg cgccgcccag cccgttctgc
     3361 gagatctgct caccggtgac ggccttgacc acgtccgggc cggtgatgaa catctgcgag
     3421 gtctcgcgga ccatgaagac gaagtcggtc agcgccggcg agtacgccgc gccgcccgcg
     3481 cacgggccga gcatcaccga gatctgcggg atcaccccgg aggcgcgggt gttgcgctgg
     3541 aagatgccgc cgtaaccggc gagggcggtg acgccctcct gaatccgggc ccccgcgccg
     3601 tcgttcagcg agaccagcgg cgccccggcc gcgatggcca tgtccatgat cttgtggatc
     3661 ttctgtgcat gggcctcgcc cagcgcacca ccgaagatcc ggaagtcatg ggcgtacaca
     3721 aagacggtcc gcccatgcac cgtcccccag ccggtcacca caccatcggt gtgcggcttc
     3781 ttggcctcca ggccgaagcc cgtcgcccgg tgccgccgca gcggctccac ctcgctgaac
     3841 gaatcctcgt ccagcagcag cgcgatccgc tcccgagccg tcagcttgcc cttggcgtgc
     3901 tgcgcctcgg tcgcccgctc actcgggcca ctgcgggccc ggtccttgag gtcgcgcagt
     3961 tcagcgaccc gcccccgggt gtcgaccggg gcgggcgggg cctggtcggc ctcctcggtg
     4021 ctcgcctctt gcagaaccgt catctccaac cactcccagt ctgtccggaa tcgctcggcg
     4081 gccggatcga cggctccacc actgcgtcgt ggggggcggc gcacaacggc agggtcggct
     4141 gcggcggctg cgaacacttc ccttacgacc ttacgagcgg agggctcatc gcacgggcgt
     4201 cgggtccgta caaggtccag ccggattcca tgtccgagcc gaacaggagc cgacggcgca
     4261 gcagcggcgc gcaggtgtcc gcaggcggcc gacggaccgc cgggcggcat ccggcgtccg
     4321 ggccgaaacc acaggtcagc ggagtccggc ggggtccatg ccgggaggcg cgagccgatc
     4381 cggaccgtgc ggcgccggat catccggtac cggcccacgc gggcggcagg tcgtcgggag
     4441 tacataaatt cgaacgggtg cgccgaacgg gtggcaccgg ggccggcaca tcagcgccac
     4501 cccgtccggt gagcgatcca ggttcgcccg attgccgcca tctcggcctg gtagccgcgc
     4561 aggtgcggca cgccgggcgg agccggaaga cgggaactgc gttcccagta gccggcctgc
     4621 gccgcggcga acgaggtgac cgcctcgggc ggggcgccgt tccaggacgc cacgtcggcc
     4681 atcagctcct cggcccgggc cggactgtgg ccggcgcgga tgagctgcgg caccagaaac
     4741 gcggggtcga tccagggcgc tccctggtgg aggtaggccc agtcgatggc gagggcgttc
     4801 ccgtcccgca tcagcatgtt gtcggcgcgc aggtccacat ggagcaggca gtcgccggtg
     4861 gagtcggcgc gccagtcccg ctcgatggcg gccagcttcc ccaggtgccg cgcggaccac
     4921 gtatcgaggg cggcgtgctg gtcggcgagg gtgcgccagc cgtggaagcc gccctggagg
     4981 acatcggcca cggccggcgc gtcggggatc ggggacgggc tgacggtctg cggaagccgg
     5041 tcgagcaggt ggagcaccgc accgaggtcc ggcgagcccg gggcgaggtc gggatggccg
     5101 ccgccgacgt cctcgaaagc catcagcagc catccgccgg cctcccaggc gtcgagcagc
     5161 cgaggcacgg gcacctgggc gggcagtgcg cggttgaccg ccgcctcggt ggcgtacatc
     5221 gagtaggcgg cgtggtcggt ggcgatgccc ttgagaaaga ccgggcggcc gtcggcaagg
     5281 gtcgcgcgga ccgcgagacc cgggctgaac ccgcctgcct gcggcaggct ccgggcgacg
     5341 gacgagccga gcaccgcagt cacggactcc cgtgcctcgg gcgcgagttg ggcccagcgc
     5401 ggcctcacgg aggtgcgtac ggcagggtcg gagggtggca cggcagctcc tgggggcggg
     5461 cccggtacgc cgggcctcag acggttgtcg agccgattac gccgggtgac acccaatgat
     5521 gcggttgtcc aagaggtccg tcaggtacgc gatgacatcg gcaccgacgg gaagcacggg
     5581 gatcgccgct cgtgcccgct acttgatggc gtcgatcgct cccttggcca gttctgcgga
     5641 gatgcgcgcg caccgggctg cgtactgctg gaggtgtcgg gccgcgaagt cgtcggcgtt
     5701 ccaatcctcg gcccggatgt cgccgtccgc ccagatgtaa gcccatccgg agtcgccgga
     5761 ggtgaggggc accttccgca ggtcgtaccg gtcgtcctcg aaggcgtcga ggatcgccca
     5821 ctcctcagtg ctgaggtcgg tgagcagcag cccgagcgtc gtggcgttgg gtgcggcgac
     5881 gagcccgggg tagacccgtt cttcgagcgc tgcggcacgc catccctgcg cggaggccgg
     5941 cgtgcgtggc ggtacccgcc ccagcagcgc ttcgagcacg gcatcgaact gcagcgtgcc
     6001 gtagacgaag agggcttccg ggccgtcagc gagtcggttc cggcgagcgg gggtcaccgg
     6061 gccccgggcc tcctggttga tcggctcagt catgtgcggt ccggttgtca gcgggtcgag
     6121 ggcaggaaca tggcgtcgta gacgggcgac tcgggagcgt gcttgatccg ccccacgacc
     6181 gtgtaccccc agcgtaggta ggcatcgtgg gctggctgat taccaacgat gcaggtcaga
     6241 gccgtgacac cctccgctcg cccggtgatg accgtatcgt gaatccgacg ccccagcccg
     6301 tggttcgtgc actcgggcag caccatcagc tcacgcagcc agaagacctg gccggcctcg
     6361 gccatctccc gcagcgtttc cggcctccgg tcgccgaggg agatccacca cggtttgtcc
     6421 gcaggcaggg ttgcaccgtg cacatagccg acgatccggc cgttcaggcg agcggtgagc
     6481 gtctcgaacc cctcggagtc gaaggcggcc tccaggcggt cacggaacgc ctggtcggag
     6541 aagaaggggt cgccgatgta agggggcacg tcatacacct tggagtacac ctcgaccagc
     6601 tcgtccgcga tgccctttgc cgatggcccg tcataccgtt ggtattccac atccatgggt
     6661 tgcatctctc ctccggcggt gttcaggcgc catatgcgcg tatctgttcg agcaggtccg
     6721 ccactccgct gctgcggtgg tggggagcca gtccatcgcg gacgatcttc aactgttcga
     6781 ccgcccggtt ggaggacatg ccgccctcga taaggcgcag agccttggtg gtggcggcga
     6841 tgctgtggtc gatgtctccg ttgtgcaagg ccgcgacgga cagtcggccc aggcacattc
     6901 cgcgattgcg agagtgggcc acatcctgaa gggcttcgga cttcgagagg agcttctgtg
     6961 cacgggcggt ctgcccgagg tcgagccgac acattccttc gaggcacgtc agctctgcca
     7021 tgttcaagaa ggtggtccag tccgggtccc tgacgtcgtc accgcgttcc cattccgccc
     7081 aggcttgccg gatcgcggcc tcggagctga agcggtcgcc gatccgggcg tacccctgag
     7141 cctcacggat tgccaacaac gcgatgactc ggttcggggc ctgccactcg ccggcgtgtg
     7201 cgtgggccag gcgggcgaag cgcacggcct cccggccctt gttcaagtcc acggcctgcc
     7261 gtgccaggtt gctcagggtc cggcacgcga gcatgtcgtc cccggtgagc atggctgcgt
     7321 tgagcgcttc ggagaagtac tggtgggcct ttgcttgcaa gcccgcgtcg tagcagaacc
     7381 acccaagcga ggtggtgaac ttcccggcca cggcgtggag ctggcgcccc agcgtgtcgt
     7441 cgtagatgcc ccggtcgatc atgtggtgca cccagtgcag gtgtgcccga gtcggcctcc
     7501 acagtcgatt cccgccgaac tgctggtcga tggcgtccat gtcgtccgct gcctcgcgca
     7561 gcagctcgac ctccgacgcc ccgatgcgcc agtctgcgga gctggtggcc cccgtcgtgg
     7621 tctccgccag ccaaggcggc ggctgatcgc tcatcggggc ggtgctgcgg gcgccgaaga
     7681 agggaaccac ggcggcggcg ctccgggtga tcgggggcat cggcataacg gcaggcaggc
     7741 tcgatccgcc gccgcgaggg cgaaagccca gttcctcgat gggccgttgc cagtagacgg
     7801 agagcacctg ccgggtgtcg gggtgcgggg acgggggatt ctccgcctcc cacttcgagt
     7861 actgccggac actgaaggtc ggcgccttgc cgattcggcc ttctgcggag aggcgcgcag
     7921 cgagcgccga gagttcccgg acaacctgct cctgcgtgcg gttgaggctc tcgcgtaacc
     7981 gcttcatctc ggacatgggt acccctcgcc atcccgtttc gtggccaccg taacggctcc
     8041 ggacagcgtg gtacgaggcg tcgtcaacgc agcgcccagg tgggagagaa agggcgggcg
     8101 aagggcaggt agagggctac tggagtaccg gtgaaagggc ctggtcttcg gcgtcccact
     8161 tcgctgcact aagtgacacg gcatgcactg tgtgtgttga tggcgcctgg agggctcatg
     8221 gagacccgca ccgagatcgg tgtgccgccc actgcgtccg atccgcaggt cgcggagggg
     8281 ccgcgcccgc cccgccacct gggaacctgc atggctgtac cacggttgct ccggaagacc
     8341 tcgcggctcc gcaagctgcg gctcagacaa ccgttccggc ggcgtacgaa taggcaccca
     8401 gttcctcggc gcgcggcgtc gagaaggaga acttccgtgg acaacggccc cgacatgatg
     8461 actgaagcga actcctcggc caacgaagac cagttgcgtg atcagatgat caggcggctc
     8521 atcgagctgg gggccctccg aagcaggcag gtcgtggccg cgttccggaa agtcccgcgc
     8581 cacctcgcaa cccctgacga ggacatggcc accgtctaca gcgtggaacg agctgtgatc
     8641 acgaagacgg atgccgacgg cgttcagctc agctccgtgt cggccccgcg catccaggcc
     8701 atgcagatcg aacaggccga catccacccg gggatgcagg ttctggagat cggctccggg
     8761 ggcgtcaacg ccgcatacct cgccgagatc gtcggcaagg acggcctggt cgtcaccgcc
     8821 gacatcgatt cggaggtcac tgaacgcgct tcggtgttcc tctcccaggc tggctacgac
     8881 caggtccaca tcgtcaccgt ggatggagag aacggggtac ccgagcacgc cccctacgac
     8941 cgcattctcg tgacggtcca ggccgccgac atcccccctg cctggctcga ccagctcaag
     9001 gacggcggac ggctcgtcgt gccgctacgg gtgcgcggta tgacccggac cgtggcgttc
     9061 gtccgccacg gcgaccgcct gctcagcgac gggttcgagc tttgcggctt cgtgccgatg
     9121 cagggcatcg gagagaaccg cgtgcgcttg gtcctgctgc acgaggtgag tggggaagag
     9181 gtcgggctcc ggctggacgg ccaccccgaa cccgatgtcg aagcactgag tgcggccctg
     9241 cacacgccgc ccgtcaagtc gtggtccggg gtggctctgg caggcgacga gtcgaacgag
     9301 caccttgacc tgtggttgac gaccgcactg gacaaccttc cgctgttggc cggacaacag
     9361 gccgcccgtg cccggggcat cgttgcctcg atctccccac acggcatccc gaccctggtc
     9421 gaggccgaca gcttcgccta ccggacggtg cgccctaccg atgaccccga ccgcttcgag
     9481 ctgggcgcca tcggtcacgg tccccatgcc caagaggtcg ccgaccgtct ggtcgagcag
     9541 atccgggtgt gggaccgagt gcaccgtagc caccgtgcac atatcgaggt ctatccggcc
     9601 ggcacgccgg acgacgtcct tcccgcaggc cgcgtcatcg accggccgca cacgcggatc
     9661 acgatcacct ggccgtagca agcccggggc caggctgtaa gggcacgtcc aaccacttgt
     9721 tcaggaggaa cgagatggca ccacagagca gcaccctgaa ggccgccacg gacttctcgg
     9781 gggagggcat gtcggacttc gacctcagca tcgagaccgt tgcgtccgcc ccgatcgtcc
     9841 ccggcctgct gaacgacacc ggggacggct gcggttccac ctgccagtcc gcctgctcga
     9901 acagcacctg catcagcggc tgacccggtg gtggggggcc ggggccggat tctcaggccc
     9961 tggccccgcg ccaatccgac cagagaacgg gggcacaacg atgtaccacg ccgttgacgc
    10021 ggccttgatc agggcctcgg cgcgtccgct ggcggcggag ctgcctcctt ggccgaacct
    10081 ggacggcagt agccctgacg atgtggaggg gtggcgcgag tggataggac aggtctgggc
    10141 gaccgacgcc acggccgagg ccatcacgtt cgccagcccc gtcttggccg aggctgtacg
    10201 cggtgtcctc accggccgtc ttcggcagcc ccgcgcaacg ctgcgagcca cgctgtctct
    10261 gatgcggtac ctcctgcgga tgcagtaccg gccgactcca ttcggtctgt tcgccggcac
    10321 cgcccccgta cgtctgggtc ggacggcaaa ggtccatcgg ggcacggacc atcgcggatc
    10381 cgcccgacct gatgccgagt ggttggccga ggtcgcctcc gacctggaga cccgctccgc
    10441 cctgctccgg cgccttccgg tgatggcgga tcccacccgg atcgtccgag gcgccaaggt
    10501 ggtcgtcccc caccagccgg gcgctgacgg gccggtggag atgagcatgc ggcacacacc
    10561 tgccgtcgag gtggtgctca gcctcgctca ttcccccatc accgccgggg agatcgtggc
    10621 cgaactccag gccgactatc cggacatgcc cgtcgccgcc atcgaggaca tggtgcgccg
    10681 cttggtcaag cacgggctgc tcctcaccag cctgcgggcc cccatgacca ccgacgacgc
    10741 cctcggacac ctcatatccc agctcgacat cctcggggcg ggcactgtct ccgagaccgg
    10801 cgggattccc ggacaacttc gccggattca ccagctcctg acccggcatg acgccgctcc
    10861 cgccgacgag cagcgcacca tccgcgccga ggccgcccac cggatgacgg ctgtgaccga
    10921 ggtgacggaa cgaacgctca tagtcaacct gcgcccggac tgcgacaccg tcctgcccct
    10981 ggtggtggcc gaggaagcac agcgcgtctt ggcggtcatg gcccgcatct cgccgtaccc
    11041 tgccggaccc ccggcctggc aggactaccg cgcacgcttc ctggagcgct acagcatggg
    11101 cgctctggtg ccggtacgtg atctcaccga cccggacatc ggactcggcg tcccggccgg
    11161 ctaccggggt tcggttctca agcgcccggt gctcgcgaca agtcgccgcg atgaatacct
    11221 ccttgcgctc gcccaggacg ccgcagcgaa ccggacccgc gaggtcgtcc tggcggaaga
    11281 ggacgtcgca tccctctccg tcggggactt cgtccaggtg cccgcccacg tcgaactgtg
    11341 cttcaccgtt ctcgcgaggt ccctgggtga cctgcggcag gggcggttcg cattggacct
    11401 cgtgggcctg tcgtcggccg ctggtaccac cacgggccgg ttcctggcca tgttggagca
    11461 gcccgaccgc gatcggatga gcgctgtgta cgccggcctg cccaccttgg aagacggagc
    11521 ggtccgtgcc cagatctcca gcccaccgct gcgcctgcgc actcagaacg tcagccggtc
    11581 tcctgcggtc gtgccgcacg tgctctccct cggtgagtac aacccgaccg ccaatctcga
    11641 cctggatgac ctcgccgtcg gggcggacgc ccggcgcctg ttcctcgcct cgctcaccac
    11701 cggacagcgc atcgaaccgt cggtgatgaa cgccgtggaa ctcaccaacg ccacccaccc
    11761 acttgtgcgc tttctgagcg aagtacaccg ctcgcacgtc gccgtcatgg ccccgttctc
    11821 gtggggggct gctgctcggt tgccattcct gcctcaggtc cgcgtaggcc gcacgatcct
    11881 gtcccgggcc tgctggcggc ttacacgcag gcacgtcggc accgcagccg gggccgactg
    11941 gatgcggcgc ttcaccgact ggcgctgccg gtacggcgtc acccgaaccg tgttcgtcgg
    12001 gtccgacgac cagcgtctcc gcctcgacct cgaccatccc gctcatctgc ggattctccg
    12061 ctccgagctg gagcacgcca gcgtgctcac cctccatgag gcccctgagg aagacgcctt
    12121 cggctggctc gggcacgcgc atgagatcac catgccgttt gcctcggacc tgccccccgc
    12181 ccgccgcatc gacgccacag cggttgtccg ccgcgaggtc gggaggctgc ccgggaccac
    12241 gccctgggcc tatctcaagg tctacagtca cccagaccgt gcttcagaga tcctggccac
    12301 ctgtctgccc gctcttctcg accagtgggg agacgagacg cctcagtggt ggttcactcg
    12361 ctacggcgac ccgggcactc acctgcgcgt gcggatccgg ctggcccgac cggatgcctt
    12421 cggagaggtc gcacaacgag tgggcgcatg ggcggcagcc ctccggaacg acggactggc
    12481 cagtcggatc cagtgggaca ccgatgaacc cgagatcggc cgctacggca ccggccatgc
    12541 cttggacgcg gcagagcgct acttcactgc ggactccgcc gcagccatcg cgcagatggc
    12601 cctccagatc ccctccggct tgcgccaggc cgtcaccgcc gccggcttcg tggacatcgc
    12661 tgacgctttc accggcggac cggcggccgg acggcgctgg ctggtcgaga acctgctgaa
    12721 gtcccaaggc gtcgcgcccc cacgagacgt tcaggcacat gccctccgcc tcgctgcccc
    12781 cgacacaggc ttggccgctc tgcgctccct tcccggcggt gagggcgtca tcgccgcctg
    12841 gactcatcgg cgtcaggccc ttgggcagta ccgggcctcc ctcgaagacg ccggcgctgc
    12901 acccgctgcc gtcctgccct ccctgctgca catgcaccac aaccgggccg ccggcgtcga
    12961 caccgacgac gaggtcacct gctgtcgact ggcacgtacc gccgcgctgt cctggaccgt
    13021 tcggcagaaa ggagccttgc ggtgatgacc gtcccgtcgg ccctcgaccc ggccaccgcc
    13081 actcggcagt ccctcgcgca cggtcccctc gggatggccc tgctccatgt cgagcgggcc
    13141 cgctgcggga atggtccgtg ggaggccgtc caccgccgac tcgccgtcat cgggccgctg
    13201 atcgagggac ccgaggcaag tctgttcctc ggtgcccccg cgatggcata cgtcctgcac
    13261 ctggccgccg ccgacagcaa ccgttacgca ggagccctcc acgcccttga cggcatcgtg
    13321 gccgcacaca cccgccgccg cctggatacc gctcacgacc ggatcgacaa gagcaggcag
    13381 gccgctttcg ccgagtacga cctcctgcgt ggcctgaccg gactcggcgt tctcctgttg
    13441 cgccgtcagc cggacagcgt cgagacgaag agggtcctgg agtacctggt gcggctcacg
    13501 gaaccgatca aggggccgaa ggggatccgg atcccgggct ggtgggtgtg gcacgctccc
    13561 acgaatctcg gtgcccccac cccaggtggc cacgccaacg tcggcctcgc ccacggcatc
    13621 gccggaccgc tggccctcct cgcacttgcc aagcgcaagg gggtcgtcgt ggacggccaa
    13681 gatgacgcca tgatgcggat ctgccgctgg ctcgaccgga tacgccagag cgaccaccgc
    13741 ggaacccgct ggcctcgatg ggtcaccgag gcggccgtcg tacccgtccg tccggccgcg
    13801 ccgtcctggt gctacggcac acccggcttg gctcgcgccc agcaactcgc cggcatcgcc
    13861 atggaggatg accaccgcaa gaggatggcc gagcgtgcac tcctggactg ccttgccgac
    13921 ccgctccagc tcaaccgact caccgatcgt ggcctgtgcc acggtgtcgg cggacttctg
    13981 cgcaccgtcg agcgcgtcgc ggaggacgcg gagaccccga gcgtgttcac cgaccggctc
    14041 caccagctca gacagcactc cctcacgatg ggccccccgg aggaaaccgg cttcctcgaa
    14101 ggcgcagccg gggcggccct ggccttccag tgcgcggaac cggacgccgg aggtgtcggc
    14161 gactgggatg cctgcctgct cctggtctga ccgcaggcat gaagaaggag accccgggat
    14221 ggacctacac gacagctgcg cggccgaaca agccgtgctc tccgtcctcg ccgggacgtc
    14281 gatcgaggac accgccgcgc ggctacggac atcacccacc cggctggccg aagccgtcga
    14341 actgtaccgc gccgccggcc gtgccgctct cgacgctcag ccgctgccct ccggctggca
    14401 tcagacgtac atcgagtaca ccgactacct ggccgcagac cgtgccttcc gagcccacct
    14461 tctgccgtgc ctccgcgacg gagtcggcac aggactcgtc ggtgggtggt ggttcctgcg
    14521 caagcgcccc tgttggcgcc tgcgggtgca gccgggcccc ggcgtcatcg tcgaggacgt
    14581 gatcgagcac atcacggatg ccctcgacag cacggtgtcg tcgggcctgg ccaagcgctg
    14641 gtggccttcc ctgtacgagc cggagaccgt cgcgttcggc ggcccggatg gcatggagat
    14701 cggccacacg ctgttccacg acgacagtgt cggtgtcctc gactacctac agcgtatgaa
    14761 caccgacccc gccgggctgc tcgacgccaa ggcaacctcc ttcctcgtca tcaccttgtt
    14821 ccttcgcgcg gccggacagg agtgggccga acaaggcgac gtgtgggcac gtatcgaaac
    14881 cacgcggccc ctgcccgccg aggaggcgcc cgccgagaag atcgtcgtca tggctgacac
    14941 actgcggcga ctcctgatgc tcgatgccgg cgctgcactc gcggtcgaag gccctctcgc
    15001 gtccctcagc gcttggacag ccggtatgga gcggggcggc cgggccctcg cagacgcagg
    15061 acgggaaggg cgcctttcgc tcgggctgcg cagcatcctg gcccggcacg tcctcttcca
    15121 ctggaaccgg atgggcttca cgagccgtca gcaagccatc tgggccaggg tcgcgaggca
    15181 ggcgatcctc ggctgctgac cctgcatccc tgctgaccct gctggcctgg cgatatcggc
    15241 cccggtgctg gtgcgctcgc gaaatcaata cagcttcccc gagcctggct tgcggactcg
    15301 cctacctcga cggggagttg gtcccagcgc ggcctcacgg aggtgtgtac gggagggtcg
    15361 gagggtggca cggcagctcc tggttactcg ccgatgtcct cggcccagag atccggacgg
    15421 gccgcgatga agtcccgcat cagggcgaca cactccgggt cgtccagcac ggtcaccgac
    15481 acgccgtgct ccgcgagccg cccatggccg cccgagaagg tcaccgcctc gccgaccacc
    15541 acccggccga tgccgaactg gcgcaccagc ccgctgcaat accagcacgg agagagcgtc
    15601 gtcaccatgg tggtccgccc atacccgcgc agccgccccg ccgcccggaa cgccgccgtc
    15661 tcggcgtgca tcgacggatc accgtcctgc acccgccgat tgcgcccccg ccccagcagc
    15721 tccccgtccg gcccgaacag cgccgccccg atcgggatgc cgccctccgc caacccggcc
    15781 cgggcctcct ccatcgccac cgcgagcatc gcccgcgcgg ccgtcccgtc gtccatgctc
    15841 cccaaccgtc gtcgcatccg ctgctccacc gcttcagcat gcccgcaacc agcccgtcgc
    15901 acttcggcgc ggtcacggcg attcagtttc tcccctgcgc gctcacggtg cgcaggtggg
    15961 cataccaggt gccgatcgag tccttgtagc cctgcggcat gacgagcccg ggggcctcct
    16021 cctcacggaa gaggccgatc cccgtggtct tcgccgaagt cgcccccccg ctgcccccgc
    16081 gcgcagcatg ctggaagccg atccagcacc cgaggatggg gacgactgtg agaaacctgc
    16141 gcatgctcgg caccacgtcc gacaagaacg agtaccccac cctgtaggag gacctggaca
    16201 ccggcgagat cctggttcag ggggacgcca tcaccggtcc ggaggacatg gcccagctca
    16261 gcaatgtccg cccaggtgag gcgttcgtcg tcatcccccg tgagctgctg ctgcgcttcg
    16321 ccccgaagga gtgaccgggt gacagaactg gcctcgacgg ccgtcctgaa cgatctgttc
    16381 gacacgttcc agcacaccgc ctggcggctg gaggtgcgac gggcctacga cgccgaccag
    16441 cggaccgacc tctacaagcg gttcctgcgg ggcgaagggg tggaggagga caccagcggc
    16501 ccctggtaca cctcccggcg gcagatggcg gctgagggca agcgggtgga gcgcgtacgg
    16561 ctggtggacg ccccgctcac cgagaaccag cggttcctgc tggcgcgggc tccgcacatc
    16621 atcggggtgg gcgaggacgt gcggtatctg tggcggaccg atgccgagaa gctgggcctg
    16681 cccatggagg acgtctggct cttcgactcc cgcctcgccg ccaggctgca cttcgacggc
    16741 gaccgcaccg ccggagtgga gctgatcgag gaaccggccg aggtcctggc gtactgccag
    16801 gcgcgagacg ccgcctggca cttcgcggtc ccctacgccg gcttcagggc gcgggtacct
    16861 tccccggagt gagtaccgac taccagaggg cccggggcga cctcgatgca ctcgccttcg
    16921 ttcccgttgc tgtagctgga cttgacccac gtggtggtgg acaggtcggg gaaggtgctc
    16981 atggggctta ctcctgtggc tcggtggatc aggagtggcg gggcctcggt ggggagcgca
    17041 gggtcaggcg gtgtcgaact cgcccgttgt ggcggcggtg atgaaggcgg tgaaggcggc
    17101 aggggtgaag gtgagggtgg ggccgttggg gtccttgctg tcgcggacgg ggacggtgtc
    17161 ggggaggttg agggccactt cgatgcactg gccttcgttg ccgccgctgt ggctggactt
    17221 ggtccagagg ggggtggtgc tcatggcgtg tactcctcgg gggatgagtg aggcatgagc
    17281 ggtgagaccc cgctttcctt ggggtgggtg gcggggtctc cggggtggct gagtcagacg
    17341 gtgccgaact cgcccgctgc ggtggcggtg acgaaggcgg cgaaggcgtc ggcggtgaag
    17401 atcagggccg ggccgtgggg gtccttgctg tcgcggacgg ggacgatgcc ggggaggccc
    17461 ggggcgacct cgatgcactc gccttcgttc ccaccgctgt aactggactt gacccacctg
    17521 gtaagggtca ggtcgggaac gttcatgggg tgtattcctc catcaccttg cgcatcagga
    17581 ccagcgacgc ttctggagac agtgcgtcag ccctcaaccg atcgtaggtc acggcggcgt
    17641 cagcgaccac agccggtgag tcgatgacct ggcccgagag cgggttctcg acatagagaa
    17701 ggtctgggtc ctcggcgaat ttcagcaagg tgaacccaag atgtgtggag ggcgccccgg
    17761 acgaccaagg gagcacctgg agggtgatgt gcggagactg agcgtccttg acgagccggg
    17821 acaactggtc gtgcatgacg tgccgaccgc cgacctcgcg ccgcaggcat gactcatcaa
    17881 ggacgcacca gaggagcggc ggggcgcttc gctccatgat cacgcggcgc ttgagtcggc
    17941 gggcgactct cgctttgatc tcgtccaccc cgtcccgtgg gtgtgatgcg cggaagacgg
    18001 ccgtcgcgta gtcctcggtc tgcaacatgc ccatgacgag agccactgag tagttgagga
    18061 tgctggtcgc ctgccgctcc agctggagat acgggatgaa ccagtcggga tatccgctct
    18121 gggtcgcccg ctcccgcaac cgggcgaagg attcagggga gccgaaaatc tgatcgcacg
    18181 ctcggcagaa ctccgggctg gccagccgtt cacccgattc caccttggcc acgtactgct
    18241 gcccgtactg cgccttctcg cccagctcac gttggctcaa ccccgcgtgc agccgccatg
    18301 cccgcacctc ggcgcccagg atctccgccc cgctggcgcg gcctcgtccg gcgcggccgg
    18361 tcgttgattc gctcatggcc caagccccct tcaccccaag tgacatggcg tggtgtcacg
    18421 cctacccggc gtagtcgcct tggggtcagt cttgcacttg tgcgaagtgc acgtgaggga
    18481 agtgcagaga gaggtggacc ggcatggaga gggcaaccgc aagcccttcc ggggcatatg
    18541 ccaatgacgt ggcttcggat tcagggaagg gctttcgcgg ccaggagccg cccgaagtcg
    18601 gcaccgtcat ggtggacacc cggacgggtc gggtcgggga gtaccggggg tcggtcggcg
    18661 ggcggtggat gctcaggccg cagggcggcg ggtgcgagtg gccggtcaag cccgagctgg
    18721 tgcggaccgc gttgctgagt gaccggctcg cccccgaagt ggcacggctg aacgcgttga
    18781 gccggggtgc ggccgtatga gccgaaacgg caccggcgca ctgcccgcag aacccccgtc
    18841 ctggctgtcc gtgccctgac gtgaagaaga ggaagcgcag ctgatgaccg cgtcgaagcg
    18901 gccgggcacc gtcccgtaca tcgcctcctg gagcggcgag aagcggtgca ccggcgccgt
    18961 ggtggaggac cggcgcagcc ccggccggat cgcgtaccgg gacgagcggc ccgatgaccg
    19021 tgacgagtac ggcgtgctgt gggcccgggc ggattcccgg cccactcggg ggcggcccca
    19081 gtatgggctg gtccaccccc gccgccagcg gcacgccatg cggaacctgc gctgccaggt
    19141 ctgcgacggc ccggccgaca ccgatgagcg gggcacgctc tggctgctgg gcgacgaccg
    19201 gggcgactgg cccggctggc ccgaggagat ggccgccacc acgccgccgc tctgcctacc
    19261 ctgcgccagg ctctccgtcc ggctctgccc gcacctgcgc ggccggcaca tcgccgtccg
    19321 ggtcaggaac cccgagatcg ccggggtgta cggcgccctc tacctgcccc gccccgaccg
    19381 ggcccgcccc acggccgcca ccgacacgac catcgcctac accgaccccg ccgtgtgccg
    19441 cgtcctggcc gcccagcagg tcatgcgcct acgcggctgc accctggtgg acctccccgg
    19501 gtgagctgat gggtgatcac aagcgtgctc gcccgtgccg gggatcaacc tgccgaagaa
    19561 gcaacagaca gcgcaccgag gggatatcgg accaatactc cgggaacgcc cggcggcggc
    19621 gccgcgcggc gcctacgatg cacgcacggg tcgggggcac ggggcggagc acggggcgcg
    19681 cggtccaggg gtacggcacg gggcggggga gctgcggcat gggaccggac gggaacgacg
    19741 aggccatccc ggtgatcagg gtggccgcag tggacgacca ccccatcctc ctcgacggca
    19801 tcggcgccca cttcgcccgc cacgcgcccg acatccggct ggtggcgacg gccgaggacg
    19861 tcggcgccct gctcgccgaa gacaccggcg acggcgcggc gcttgtcgtc ctgctcgacc
    19921 tgcggctgcg cgacggcagc gacatcgggt cgaacgtccg ccggctgcgg gccaccgggg
    19981 cgcgggtgct ggtcttcacc ggcgagcagc gccccgcgct ggtgcgccgg gccctcgatg
    20041 cgggggccct gggcctggtg ctgaaggagg acccgcagga ccggctggtg gaggcgatcc
    20101 gtacggcgga cacgggcgag atgtacgtct ccagccgcct cgcccactcc atcgtgaccg
    20161 atccgcgcgg cagcgtccgg ctctcagccc agcagtcgcg ggtgctggaa ctgatcgccc
    20221 ggggcctgcc gcacgcggac atcgcgcgca tgctgcacat caccgaggac actctgcaca
    20281 cccaccgcaa acgggcgatc tccgcctatg cgaaggcggg cgacgaactg gtgggaggca
    20341 ccggcgaact cgtctaccgg gccgtggccg acggccacat cgacatcggc ccggacctgc
    20401 cggaacgggc cgggccctga ccagggggtc cgccactccg gggtccgcca ccccgaggcc
    20461 ctccaccccg gggtcctacc ggcacggggt ggagacgggg ctgtcctacg cggtggccgc
    20521 cctgtcggga ctgttcgcgc tgagctggtc gatgttcctg gtctccgggg gcccggagcg
    20581 tgcgccggac gtccgcgccg tggcggcggt gttcttggtg caggcagtgg tgacggccgt
    20641 gcgcggggtg cgcgtacggc tctcccgggc ggacagcggg gtggccctcg ccctggccgt
    20701 cctcggacac gcggtgctcg ccgtgggcgg cgcttcccgc gtcgtgatcg ggcagcgctg
    20761 cctgctggcg tccccggcgg tgctgctcgc cgtcgggttc ctgccgcgcc gcgccggccg
    20821 gtgggcctgc ctcgcggcga tcggggcgca ggtggccacg ggctggcccg cggacggtcc
    20881 ggcgggggcg gtggaggggg tctggccggt ggtggcaacg gccgtggccg gcgatgtgct
    20941 cgtcccctga tgcgcgcggc gggcgcccgg gccgacctgg cgcagcggcg ggtacgggcc
    21001 gcgcgggcgg cggcaggccg ggcggagggc cgacgcgagg cccaccggcg cttccagggc
    21061 atgctgcacg acgaggtcag cacggcccta caggccatca gcctgcccgg cgtcccggtg
    21121 gcccggctga gggaggcggc ctccggcgcc gtggccgcgc tcgccgccgc cccggcaggg
    21181 ccgggccgca aggcccggac cgacctggcg gccgtggtcc gcgcgctccg gccgccgccg
    21241 gggaccgtgc tggcgatcga ggccaccgga ccggccctgg tccccccgga ggtcgccgac
    21301 gcggcggcgg gcgcagcccg cgaggcgctg cgcaatgtcg aggagcatgc cggggcccgg
    21361 agcgtccgcc tacgcctgcg gggcggcccg ccggaccgtc ccggggcggc agcggacggg
    21421 gagttcacgc tgagcatcac ggacgacggc gtgggcttcg ccgccgggga gctcgccgcg
    21481 tcctcggtgg ggctacggcg gtcggtgatc cggcggatgg ccgccgtcgg ggggcacgcc
    21541 gaggtccgca gcgcccccgg gcacggtacg accgtacgac tggagtggcg tcccccggcc
    21601 gccggaccgg cggcggatga agcggatgaa gcggagaccg gggccgggac ggtgggcggg
    21661 cccgcaggag ggcccaccgg agtgcccgct gacacgctcg ggcggatgcg ggccgccgtg
    21721 ggcgacgtgc ggcgcccgct ggccgccgtc tgcctgccgt tcctcacggc catgggcgtc
    21781 atcgcggcga tccacacggc ccgcactccg ggcaccggcc ccctgctggt ctggtacgcg
    21841 ctcctcacgg cgctcaccgt ggcgctcctg ctgcgggccg cctcgggcat cccggccctg
    21901 gtggccggag cggcctgcgc gttcgccgtt gccggggcgc tcggcagctt tctcgtcctg
    21961 cccctggcca gcctcgcgga ctacacctcg tggccggtcg gcgcggtgac accgctcctg
    22021 acgctgctgg tgatcgtccg cccggcgtgg gaggcactga cggcgctggc cctggagcag
    22081 gtcggcatcg ccgtcctcgt cgccaccggc ccgccgatcg cgccctcggt cggtgcgacc
    22141 atggcgctcc tgctgcccgc cctcctctcg cccgcgctcg gcgtgatcac gggcctcgcc
    22201 ctcggccgta ccgtggcccg cctgggcggg gtgacagcgc gcgccgaggc cgaccggtcg
    22261 gcctcgctcg ccaccgaggc ggcccggcgg gcgcgtgagg aactgcacca gggacggctg
    22321 gccgacctcg gccaggagat cctgccgttc ctcgccgcca ccgggtccgg gcggtgcgcg
    22381 cccgacgacc ccggggtgcg ggaccgcgcc cggctgctcg ccggtgcggt ccgggacgag
    22441 atccacctcc ccggtgtgct cgaccgcacc gtacgcgagc tgctgagcgc ggcccgccgg
    22501 gcgggctgtg tcgtcaccat ccagtcggac tccgacgacc cgcacccccc ggcctttctg
    22561 cgcctgctgc tgaccactgc gctgacctgc gcccccaccc cgcgcgagct cgtcctcacc
    22621 gtgaacgcgg cggcgggcgt cgcacgcgcc tccctggtcg tcctcccggg agacgagtgg
    22681 cgagcccggg cgctgcgcga ggccgtcgcc ggggccggtg ccggaacggg cgtcgtggtg
    22741 gcggactccg ccacctccac ctgggtcgaa gcggacgtcc gcgcgtcctg atcacgcaaa
    22801 ccgcccacct cgccttgcac gccctgcctg ccgggatgtc accactggcg ggatgtcacc
    22861 actggcgggg acagccagaa tgcgccgtgg ccggaaccat cgaaggacgc cggggcactc
    22921 ggccccgacg gtgatgaagg ggacggccat gtccgaatcc atccgcgacc gcctgcggcg
    22981 gttcaccacg tcggtcgagc ggtccgacga cctctccccc gcccagcgag cggggatcct
    23041 ccaggggtac gaggaagcgc tcggcaatga ggggccgccc cggctggtcc tcatcggcga
    23101 atccggggtc ggcaagtcca cgaccgtcaa cgcgctgttc aacgcgggtc aggcggtcgg
    23161 ccacagcagg gcgaccaccg accgggcctg gtccatcccc gtgcagcagg tcagcgggag
    23221 caacggcacg ctggaggtcg tcgacatgcc gggcctcggt gacgacatcg ccaactaccc
    23281 ccgctacatg ggcctctacc gcgaggtcct gccgacggcg gacgccatcg tgtggatcca
    23341 cccggccaag gaccgcatgg tccagctcgt ccagcaggcg ctggcggacc tcttcgggcc
    23401 cagcccggag ctggtcggcc gactggtctt cggcctcaac aaggccgacg agatcggccc
    23461 gcacgactgg aacgcgcccg cgaacctgcc ctcggagctc cagtgggccg cgctgcggga
    23521 gcgggaggag gacttcaccc gcagtatcag ccgggtactg cccacctggc ggggccgggc
    23581 ggtgtcgtac gcggcgctcc ggttctacaa cctgacggcg ctgttcaagg agatgatgta
    23641 cgcggtgccc gagcagcgcc ggtgggtcct ggaacagcgg atggacctcg cggacttcac
    23701 ggccctggtg gaccgcaagc tgctgcgggc cgccacggcg aggacgctgg tcgaggtccc
    23761 ggcgggcgag ccggagccgg agccggcgcc cgccccgccg cagccggtac ggcagcgccg
    23821 ggagcagccg acgacccacc caccccggtc cgtcgccgat gcgctggcgg cgctgtcgga
    23881 cgcccagtgg cgggacctgc acgccgaccg ggcccggttc gaggagttcg tccggcgcct
    23941 ggagcagggg agcgcgcgat gaacgccgag cccgggcccg acccgggggc ggacctcgac
    24001 tcgctcgtgg acgccctgcg catggtcatg cgggagcagg aggagaacct gcgggagatc
    24061 ggccggatgt cggaggtctc cttccggctg tggctcggca gcgtggccaa ccggctcgcg
    24121 gcggctgtcg ggattcccct ggcgcgcgtg cacgccttcc tcggcgacct cgcgtcgatc
    24181 gtggtcgacg cgggcgcgac gctgaagcgt tcgtaccggg acgagtaccg cagggcacgc
    24241 cgttacccgc gtgccccggc caactgacgg agagggagga ggacgccatg gcgtgggtcg
    24301 agttcgcgtt cccggaatgc ccggtctgct cccgctcgtg ggccgtcagc cgccaccggg
    24361 actgcccggc ggacgggggc cggagcgcag gcggcggtgg cgagggcggt ctggacgtgg
    24421 atccggaccg gtcgcaggtg cggtgcacag gctgccgacg gacctgggca gtgtgggaga
    24481 cgcgcttcca ctgcgcctgc gggcaccggt tcgaggcgca ggaggtggag gaggcggtac
    24541 gggagatcat ccgggtcgcc tcgctgctgg cgcaggtgct ggcccagcag gccaaggacc
    24601 tggccgagat ccgccgcgcg ggcgaggtgt cgttccgtgc atgggtgagc cgcttcgccg
    24661 acgcggtggc aagctcgctc ggggcgctgg cgggccgcct cgtgggccgc ctgctgcggg
    24721 ccctggactg aacgagcggg cgggaccggc cctgagccgg tcccgcccgc tcgtcgtcgc
    24781 tctcagctgc cgttctccgg gccggtctcg tcggacttgc ggcgcagctc ctcctcgcgg
    24841 cggcgcaggt ccgactccca ctgcttgagc atgtcctcgt gctgggcgtt gcccttcttc
    24901 agcgaggcca ggaactccgg gtcgtcgtcc ggcgccaggg tgcggcgctg cggctgctcg
    24961 gcctccggga acccctcggc cgcgccggac ggccagggcc cctggcggcg ggccgccgcc
    25021 gggccacggg accggccggc gatcatccag acgatgggcc cgaccagtac ctcgccgaag
    25081 agcaggatga tgatgatcca ggccaccttg ggcaggtgcc ggacctcctc ttcgggcgtg
    25141 agcaggcagt cgatgaaggc ccagatcatc agcgcgatga tgatcaggaa gggcaggaa
//
