LOCUS       NZ_CP031264            25356 bp    DNA     linear   CON 10-DEC-2024
DEFINITION  Peterkaempfera bronchialis strain DSM 106435 chromosome, complete
            genome.
ACCESSION   NZ_CP031264
VERSION     NZ_CP031264.1
KEYWORDS    RefSeq.
SOURCE      Peterkaempfera bronchialis
  ORGANISM  Peterkaempfera bronchialis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Peterkaempfera.
REFERENCE   1  (bases 1 to 7090212)
  AUTHORS   Nouioui,I., Klenk,H.P., Igual,J.M., Gulvik,C.A., Lasker,B.A. and
            McQuiston,J.R.
  TITLE     Streptacidiphilus bronchialis sp. nov., a ciprofloxacin-resistant
            bacterium from a human clinical specimen; reclassification of
            Streptomyces griseoplanus as Streptacidiphilus griseoplanus comb.
            nov. and emended description of the genus Streptacidiphilus
  JOURNAL   Int J Syst Evol Microbiol 69 (4), 1047-1056 (2019)
   PUBMED   30741626
REFERENCE   2  (bases 1 to 7090212)
  AUTHORS   Batra,D. and Gulvik,C.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-JUL-2018) Bacterial Special Pathogens Branch, Centers
            for Disease Control, 1600 Clifton Road, Atlanta, GA 30329, USA
REFERENCE   3  (bases 1 to 7090212)
  AUTHORS   Gulvik,C.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2018) Bacterial Special Pathogens Branch, Centers
            for Disease Control, 1600 Clifton Road, Atlanta, GA 30329, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2018
            Assembly Method                   :: HGAP v. 3; Pilon v. 1.22
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 176.4x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003258605.2-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:52:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,114
            CDSs (total)                      :: 6,019
            Genes (coding)                    :: 5,833
            CDSs (with protein)               :: 5,833
            Genes (RNA)                       :: 95
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 186
            CDSs (without protein)            :: 186
            Pseudo Genes (ambiguous residues) :: 0 of 186
            Pseudo Genes (frameshifted)       :: 60 of 186
            Pseudo Genes (incomplete)         :: 147 of 186
            Pseudo Genes (internal stop)      :: 2 of 186
            Pseudo Genes (multiple problems)  :: 22 of 186
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:20:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1913335
            Orig. end                         :: 1938691
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031264.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25356
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="9"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25356
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25356
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15356](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15356
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(881..2146)
                     /locus_tag="C7M71_RS08440"
                     /old_locus_tag="C7M71_008440"
     CDS             complement(881..2146)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018846751.1"
                     /locus_tag="C7M71_RS08440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008440"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_111489966.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.9e-63, bitscore:
                     211.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDTNETHVIVGAGLAGAKAAETLRSEGFTGRVILLGDEREKPYE
                     RPGLSKKFLTGAEERDALRVHDPSWYTAHEVELHLGQPVTALDREAKEVRLGDGTAIRY
                     QKLLLATGSSPRPLRVPGADLAGVHYLRRLPHAERLRAVLRNLGRENGQLLIVGAGWIG
                     LEVAAAARGYGAEVTVVEPQPTPLYGVLGPELGGFFADLHRDRGVSFQLGASITEVVGQ
                     DGMVLAALTDTGEELPAHAMLIGIGAAPDTALAEAAGLEIAPREEGGGVAVDASLRTAD
                     PDVFAAGDLASAYHPVFGRRLRVEHWANALNGGPAAARAMLGREVVYDRLPYFFSDQYD
                     LGMEYSGYAAPGEYAQVVIRGDAGKREFIAFWLDGENRVLAGMNVNVWDVTDPIQRLVR
                     SRRPVDPERLADPGVPLDALPG"
     misc_feature    2182..2195
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            complement(2311..3612)
                     /locus_tag="C7M71_RS08445"
                     /old_locus_tag="C7M71_008445"
     CDS             complement(2311..3612)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008832 - dGTPase activity [Evidence IEA]"
                     /GO_function="GO:0016793 - triphosphoric monoester
                     hydrolase activity [Evidence IEA]"
                     /GO_process="GO:0006203 - dGTP catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142294.1"
                     /locus_tag="C7M71_RS08445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008445"
                     /product="deoxyguanosinetriphosphate triphosphohydrolase"
                     /protein_id="WP_111489965.1"
                     /transl_table=11
                     /translation="MDDTDQALAVEPAYDPAAEARWVPEPDKRPGRTAFQRDRARVLHS
                     AALRRLAGTTQVVAPMLSDFPRTRLTHSLECAQVGRELGAALGCDPDLVETACLAHDLG
                     HPPFGHTGESALDQAAEGCGGFEGNAQSLRILTLLEPKRFAPAEEAPARLAPWPGRSVG
                     LNLTRAALDAATKYPWVRGEHPTEPGSRKYGVYAEDLAVFRWVRAAAPPGRRCFEATVM
                     DWSDDVAYSVHDVEDGLHAGHVDPAALGDRDERAELFRVAARHAPGAEPEELGEALDRL
                     QAQEWWPHTYDGSARDRSRLKDATSQLIGRFCLAAERATRERYGPGRLTRYRAELVVPY
                     ATRLECAVLKAVAVRYVMQRAEQAELRSRQRVVIAELAEVLVRDAPHGLDPLFRALFEE
                     AADDRARLRAVVDQIASLTDASALALHRTLVRER"
     gene            3895..4131
                     /locus_tag="C7M71_RS08450"
                     /old_locus_tag="C7M71_008450"
     CDS             3895..4131
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS08450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C7M71_008450"
                     /product="hypothetical protein"
                     /protein_id="WP_111489964.1"
                     /transl_table=11
                     /translation="MLSAAAALDRVADHPAVRQVAGFEEYRTGPGLPVKAGQVAARFIL
                     HGPDHPSVLRTAEQILRGLEQDLGIGLLIGEKD"
     gene            4138..5412
                     /gene="lysA"
                     /locus_tag="C7M71_RS08455"
                     /old_locus_tag="C7M71_008455"
     CDS             4138..5412
                     /EC_number="4.1.1.20"
                     /GO_function="GO:0008836 - diaminopimelate decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="lysA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_DAP_Arg_deC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264: diaminopimelate decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972540.1"
                     /locus_tag="C7M71_RS08455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008455"
                     /product="diaminopimelate decarboxylase"
                     /protein_id="WP_175607657.1"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 1.5e-53, bitscore:
                     180.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 4e-21, bitscore:
                     73.6, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPTSGTGELSGALSGPRVATVAERHGTPVWMYDAARIRAQIA
                     RLRQFDVIRFAQKACSNIHILRLMREEGVLVDAVSVGEVERALAAGYTVGGPEEPVVFT
                     ADLLDRATLRRVVELGIPVNAGSPQMLDQVGRAAPGHPVWIRINPGFGHGHSRKTNTGG
                     EHSKHGIWHEYLAESLELVDRHRLDLVGLHMHIGSGVDYLHLEQVCETMVKQVRLTGRD
                     VRAISAGGGLSVPYRPGDPEVDTDRYFRLWDAARQELVSELGHPVRLEIEPGRFLVAGS
                     GVLAAEVRADKPMGGNHFVLVDAGFNDLMRPAMYGSSHRVSVLAPGGAVRGEALRDTVL
                     AGPLCESGDVFTQVEGGDVQPIPLPRAEIGDLVVFHDTGAYGASMSSTYNSRPLIPEVL
                     VDGDRTRLIRRRQTVQELLALETEV"
     gene            complement(5577..6479)
                     /locus_tag="C7M71_RS08460"
                     /old_locus_tag="C7M71_008460"
     CDS             complement(5577..6479)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036901.1"
                     /locus_tag="C7M71_RS08460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008460"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_111489962.1"
                     /sec_met_domain="APH (E-value: 1.3e-20, bitscore: 72.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIAQARERSLSILREASGRLGLPVEPGEPIRLGENAVWRLPGEV
                     VARIARPGQQAAARKEIAVARWLSDVGLPAVRPLDVEQPVEVRGHSITYWHELPPHRRG
                     TPAETASVLRRLHSLQPPTTGIIGPLDPFVRLDARIATAAAADIIDTAEQDWLRAHLRR
                     LHVEWEHLPQGRPHCVIHGDAWIGNLAVTPDGTPHLLDLERCAIGPPEWDLTSTAAGRD
                     LFAHVSTAEYEQYTRAYGYDVTSWKGFPILRGVRELRVTLFALQYASDHPGMADRARHR
                     LECLQGHHGPRPWDWPVMD"
     gene            complement(6476..7909)
                     /locus_tag="C7M71_RS08465"
                     /old_locus_tag="C7M71_008465"
     CDS             complement(6476..7909)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="C7M71_RS08465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008465"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_111489961.1"
                     /transl_table=11
                     /translation="MRPPRSGLVIAMPSEDSVPPANGPTPRQALGARIRAERAARGWTT
                     TEFVTLLNSAANGTVPGSVDRSALYRWETGRVRPTRWLPSIAKVLGISVEELLGAGELL
                     ANSPRPGTVSAPAFATAGIGRMMGVPPFGSELPVDRRTFIGAGGVAALTPGTMLALVES
                     LGRSPLPEEVRSEDVDHVHAAAAALKGLDGRYGGGGIVRDAAIAQLGWAVRLLDRRCTS
                     SLRPQLLTAVGLLAVVIGAAAFDSYAHDDARKVLSLATTCAEEAGNWGLRAHALSWRSR
                     QETWCGNLQLGLTYAELGLARADRLLPVERAWLYNACARGLAKMGRLQDTLAAVGASDD
                     AWAHHDPGREPIPVWMNFYDHAQHHGDTGHALCDIALYGGPAKEAVTRLQTAVDGHTSN
                     VVRSRALSRGRIATVLMATGDPEEASVVGTTALAEIGRLRSRRAADDMRVLHQLADPHQ
                     GNAAVDHLRERIVVAVTQA"
     misc_feature    8067..8082
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.69"
                     /tool="antismash"
     gene            8424..9656
                     /gene="fxlM"
                     /locus_tag="C7M71_RS08470"
                     /old_locus_tag="C7M71_008470"
     CDS             8424..9656
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141306.1"
                     /locus_tag="C7M71_RS08470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008470"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_111489960.1"
                     /sec_met_domain="PCMT (E-value: 2.8e-41, bitscore: 140.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDVTADPDRAAQLRDQIVDTLIADGTIVSKPVETAMRAVPRHQF
                     APDASMDEVYSAYNAVFTKKDEHGVIMSSVSAPQIQAMMLEQAGIEPGMRVLEVGSGGY
                     NAALIAELVGASGEVTTVDIDPEVTDRAARLLAGAGYTRVRVVCADATDGVPAYGLYDR
                     IVVTAGAWDIPPAWVSQLTAGGRLVVPLRMRGLTRSIAFDRAGDHLTSVSAQVCGFVPM
                     QGAGAHREELLLVTGTGEIGLRFDDGLPADPSRLDNAVRTPRAETWSGVLIGRQEPFDT
                     LQLYLATVLDGFCIMAVDPDLDTGLVAPANRWFCMAAVDGGSFAYVTTRRTADEASVEF
                     GVHALGPDAVALAERVAEQIRTWERERRSGPGPVIRVYPADTPDDQLPDGRVIDKQHCR
                     ISISWPAATAA"
     gene            9708..9914
                     /locus_tag="C7M71_RS08475"
                     /old_locus_tag="C7M71_008475"
     CDS             9708..9914
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014141307.1"
                     /locus_tag="C7M71_RS08475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008475"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_111489976.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.9e-17, bitscore:
                     59.8, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADTRVSGGATALAERPAADGAFADEFSLDVRVVVAAHPNGKLAC
                     STSDGCGSSCSGSACTSFTDDPV"
     CDS_motif       9708..9845
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MADTRVSGGATALAERPAADGAFADEFSLDVRVVVAAHPNGKLACS"
                     /locus_tag="C7M71_RS08475_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9846..9914
                     /prepeptide="core"
                     /locus_tag="C7M71_RS08475_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-4.00"
                     /molecular_weight="1922.0"
                     /monoisotopic_mass="1920.7"
                     /core_sequence="TSDGCGSSCSGSACTSFTDDPV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MADTRVSGGATALAERPAADGAFADEFSLDVRVVVAAHPNG
                     KLACS"
                     /leader_location="[9707:9845](+)"
                     /alternative_weights="1940.0"
                     /alternative_weights="1958.0"
                     /alternative_weights="1976.0"
                     /alternative_weights="1994.0"
                     /alternative_weights="2012.1"
                     /alternative_weights="2030.1"
     gene            10001..13075
                     /locus_tag="C7M71_RS08480"
                     /old_locus_tag="C7M71_008480"
     CDS             10001..13075
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378945.1"
                     /locus_tag="C7M71_RS08480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008480"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_111489959.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.2e-207,
                     bitscore: 686.6, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.5e-17,
                     bitscore: 60.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-13, bitscore:
                     49.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASSSPLRYRWRGGAILRATTDPGDLGLPGDLDLCGDAGAARARG
                     WLGQVWRREDVRDALSAASPVLCRQVDAVLADASCGARQLRRTVLSVASYLLRWQRRPT
                     PFALFAGVAAARIGSVPRASWGTGHTAFVRPDAEWLADVIGCLEQHPDLLRRLPVVVND
                     AGRMRGGRFVVPGAPADGRAHLLAPLEVSVGVTRPVCAVLDAARAPIPYDDLRSLLVSR
                     FPAAAPQQVDSVLRGLITQNMLITSLWPPMTHLDGLGHLCRELEAAGAETVGAVADLVR
                     RLYEIRDGLADQDPTAAWSARAGLIERMNAVSTVTPVPLIVDTALDCDIEIPEQVVQEA
                     QEAACVMYRLTPQPFGYQQWRDYHRAFRARYGTGALVPVLDLVADSGLGLPADYQGAAL
                     GRPPRQVTERDEKLLALIQQALLERREEIVLTKEVIADLALGQDAELIPVPRVEIAVEI
                     HAASLEALARGAFRLVVTGAPRPGASMAGRFTHLLPEPDQAAVAATYETADPGVVAAQL
                     SFAPRRRRTENIIRTRQVLPHVIPVSEHRADTDGVIGLADLAVTADARAFQLVQMSTGR
                     LVEPRVAHALEAGVHTPALARFLAEITTARSAAYKGFDFGAAVHLPYLPRVRYRSTVLS
                     PARWMLRSQDLPSHGAATTEWDKALTAWRGRLRVPERVTVVDDDQRLPLDLDHSLHRMM
                     LRRSLDAAGRLELGEAPAPDAVAWLGRPHELLLPLTLETPLAPRRPTGPLRRVAGDAAQ
                     LPGRGQVLAVHLSAHPARYDEILTHHLPSWLDPAERWWFRRHRDLARPDADQYLALYLS
                     LPHPDAYGQVARRVSDWAAELRRRHLASHLALATYEPQTGRYGHGAAMDAAHIVFVADS
                     AAALAQIRLAEKAGVPAQALAAAGMVDLAARFAASPTQGLHWLVENLPREHGPLDQALR
                     DQTLALADPYEPSAGVRELPGGGDLAAAWQTRASALAAYREHLKVERDPLTVLRSLLHQ
                     HHVRSLSVDPDDERATGRLVRACALRHTSRRDGVR"
     aSDomain        10475..10753
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C7M71_RS08480_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.50E-19"
                     /identifier="RREFam001.1"
                     /label="C7M71_RS08480"
                     /locus_tag="C7M71_RS08480"
                     /protein_end="251"
                     /protein_start="158"
                     /score="60.3"
                     /tool="antismash"
                     /translation="VVVNDAGRMRGGRFVVPGAPADGRAHLLAPLEVSVGVTRPVCAVL
                     DAARAPIPYDDLRSLLVSRFPAAAPQQVDSVLRGLITQNMLITSLWPP"
     gene            13072..14307
                     /locus_tag="C7M71_RS08485"
                     /old_locus_tag="C7M71_008485"
     CDS             13072..14307
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013000961.1"
                     /locus_tag="C7M71_RS08485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008485"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_111489958.1"
                     /sec_met_domain="LANC_like (E-value: 1.5e-43, bitscore:
                     147.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPPRPPAAPADLVELFAAALDRPAPPPPHEPWQAHSLAEGAAG
                     IALLHLQRAYTGHGTWQQAHAWITTAASGDISAADNTGLFLGVPALAFLLHAATGSPAR
                     YEESLATLDLHVAALARRRSAAALARITRGQLPAFAEYDIFYGLTGIGAYLLRRDPVGT
                     ALEQVLDYLVALTRPLRADGHQLPGWWVAHDPHGRMSSRYAGGHGNLGAAHGITGVLLL
                     LSQAARRRVTVAGQLDAIAALCAWLTAWRQEGTSGPWWPEHLSPADLRTGTTHQSGPGR
                     PSWCYGTPGIARAGQLAAIALHDHQLQREFEDALTACVHDPAQLDQITDTGLCHGWAGL
                     YQTVWRASRDALTPALRARLPGLAKALARHARPGTAGPGFLDGDAGTALALTTAANDAA
                     PTCGWDACLLID"
     gene            14289..15356
                     /locus_tag="C7M71_RS08490"
                     /old_locus_tag="C7M71_008490"
     CDS             14289..15356
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003955820.1"
                     /locus_tag="C7M71_RS08490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008490"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_111489957.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.5e-37, bitscore:
                     126.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPADRLTSPPAVPSARLPAGVPETARAVREVLAGTPLGEAALRAD
                     LDPAELATAVELFTTAGRRALAEQHGAHSRWTQLYLEFTHWASAEKTAAEHLAPLLHTA
                     QRQGDLTGWWFIRKHPCWRLRLRTSHDAAKASVPAALDGLVTAGHLRRWWPGIIYEAET
                     PAFGGGAAMTVAHELFTADSTGILALTRRGDRALGRRELSVLLCTTLMRAAALEWYEQG
                     DAWHRVSEDRPLPSDVPPDRLQELAGNIATLLRADFAPDGPLWGPGGPAEFAADWAGAF
                     RRAGQDLGAAARTGTLERGLRHVLAYHVIFHWNRLGLPLHTQSVLSWAARAAILDAPAS
                     PAPPAPGPGLQREGT"
     gene            complement(15971..16426)
                     /locus_tag="C7M71_RS08495"
                     /old_locus_tag="C7M71_008495"
     CDS             complement(15971..16426)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS08495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C7M71_008495"
                     /product="hypothetical protein"
                     /protein_id="WP_111489956.1"
                     /transl_table=11
                     /translation="MVEAGVAHHEGERAGFAGSHPSACPGVAQEVPGGEGVVAALGVSD
                     QLAVQQVCLLRAWAGHEVGHGQAEPGPEGAGVRTGYRFPEGVERGQQPFGVPAGEVLVE
                     QQCERVQALRDGFFPRLVDQADLQERERGAGASGEQVGDHVDLAAFA"
     gene            16644..18410
                     /locus_tag="C7M71_RS08500"
                     /old_locus_tag="C7M71_008500"
     CDS             16644..18410
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020700223.1"
                     /locus_tag="C7M71_RS08500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008500"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_111489955.1"
                     /transl_table=11
                     /translation="MALPQGPLDHRYRGEHPVRTLAYLLHQDRGRLALAVLAFLIKHSP
                     TWLTPLITANVIDVVVQHRPITQLWLGAGLLLVMLVLNYPFQLVYIRCWYGSARRMGTR
                     MRTALCHRMQQLSIGYHSRVSAGVLQTKVIRDVESVEQAFQQTGDLGLSALATLTGALV
                     VIGVRAPAFLPVFLVVVPAASALVMWLRGRLRAYNESFRQEVEQLSSRVSEMTTLIPIT
                     RAHGLEHTALRRVDGTLRQVLTAGLRLDRLNGQFGALAWIMLNALGVGCLAGSALAAYY
                     GWLAVTPGDVVMLSAYFSALTAAVTTLMGLTPVISKGLESVRSAGEVLEAPDLEQNAGK
                     AQVAEVRGRVDFQGVGYAYDDAERHSVRDFTLSVRPGETIALVGASGAGKSTALNLVTG
                     FLRPTEGRILLDGADMESLDLRSYRRFLSVVPQESILFEGTIRENVTYGMSDVSEERVR
                     AALRDANALEFIERLPTGLGTVVGERGARLSGGQKQRLAIARALIRDPRVLVLDEATSA
                     LDSHSEALVQQALSRLVRGRTVFVVAHRLSTIRSADRIVVMHDGRITEVGTHEQLLRSG
                     GAYAGLQAAQSA"
     gene            complement(18420..19007)
                     /locus_tag="C7M71_RS08505"
                     /old_locus_tag="C7M71_008505"
     CDS             complement(18420..19007)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C7M71_RS08505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C7M71_008505"
                     /product="hypothetical protein"
                     /protein_id="WP_111489954.1"
                     /transl_table=11
                     /translation="MGMTGDMGGAGPQDTEAVIDLTPPAPEPAAPGPGPRWLGPLVVIG
                     LPVALAAVVGTLLYRQLSAPDGTDARACPGSTESLDSATARYGVRLPAGAVDVHYLADP
                     GGAGGAKVPLHLAYRVPRATLDASMEANGLALRAETSTGWLGASRMCGLEEPSTGVARW
                     TGVLLPTGYPVTGQVSVSGNPDTAQVLLQVGG"
     gene            complement(19089..20078)
                     /locus_tag="C7M71_RS08510"
                     /old_locus_tag="C7M71_008510"
     CDS             complement(19089..20078)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006376444.1"
                     /locus_tag="C7M71_RS08510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008510"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_111489953.1"
                     /transl_table=11
                     /translation="MQKKDLRTAAGALAATGALLLTAACSGGGGSQAGPAKPAPVPVAT
                     TAPSPGSGSSAGPYAALGDSYTSGPRIPTQAGTPLGCDRSDRNYPSLVAKALGLTGRDF
                     RDVSCSGATTANLAAPQSTSDGVNPPQLAALSTRTRLVTLSIGGNDVGFVALLSRCVQA
                     GVLRSLGLDRSAAPSGDAPCKDFYTASGHDELGQRVQTAGRRLAAGLAEVRQRAPLARV
                     FVVGYPALVPESGAACPSQLGLAAGDVAFLHDEEQRLNTELRQRAEAAGARYVDTWTPS
                     LGHDACTAEAVRWIEPLSPAAPAAPAHPNERGERGMADAVLRAVRGPF"
     gene            complement(20212..21144)
                     /locus_tag="C7M71_RS08515"
                     /old_locus_tag="C7M71_008515"
     CDS             complement(20212..21144)
                     /GO_process="GO:0043248 - proteasome assembly [Evidence
                     IEA]"
                     /GO_process="GO:0051131 - chaperone-mediated protein
                     complex assembly [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135652.1"
                     /locus_tag="C7M71_RS08515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008515"
                     /product="PAC2 family protein"
                     /protein_id="WP_111489952.1"
                     /transl_table=11
                     /translation="MRDPEALYDLEREGVEAVAATAAESPGLVLLYHLGGFMDAGEAGA
                     QVVEHLLEHGEPQVVARFDHDRLVDYRARRPPMTFDRDRWSAYEPPEILLHLVHDAAGT
                     PFLLLSGPEPDVEWERFAAAVRGLVARFGVRLAVDFHGIPMGVPHTRPVGLTPHGNRLD
                     LAAAHPRWFEQAQVPGSAQGLLEYRLAEAGHDVLGFAVHVPHYVARSAYPAAAVAVLEA
                     VQSATGLVLPGTELRERVTEVRADIDEQLAQTDGELPTAIRGLESQYDAVAGAESRESL
                     LAEQAELPSADELGRRFEEFLAEQEHGAD"
     misc_feature    21211..21226
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            21689..22393
                     /locus_tag="C7M71_RS08520"
                     /old_locus_tag="C7M71_008520"
     CDS             21689..22393
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031413.1"
                     /locus_tag="C7M71_RS08520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008520"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_111489951.1"
                     /transl_table=11
                     /translation="MPVSVTLTGRMVRLEPLTERHAPALAAAAAEDRTAYAFTPVPHGL
                     KAARAYVAAALADQAAGLAMPFATVRVSDGLVVGSTRFAELDYWQGPVLWPPVPRGPLG
                     DPYAAVPDAAEIGGTWLSARAQGTGINTEAKLLMLRHAFETWGVRRISLRADARNLRSR
                     AAIERLGAVCEGVRRAHTRGLDGLVRGTAFYSILDEEWPAVRDIIELRIAAADSPSAPD
                     RPLTADPGLIPA"
     gene            complement(22679..23374)
                     /locus_tag="C7M71_RS08525"
                     /old_locus_tag="C7M71_008525"
     CDS             complement(22679..23374)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003947004.1"
                     /locus_tag="C7M71_RS08525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008525"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_111489950.1"
                     /transl_table=11
                     /translation="MAAIRTARQRAREELTLEIKEEARRQLAAEGAQRLSLRAVARELG
                     MVSSALYRYFPSRDELLTALIIDAYNALGERTEAAVAAAPPGDHRARWRALCHAVRDWA
                     REHPHEYALVYGTPVPGYQAPQATIGPAARVALVLVAVVRAAGPGPQTAARVPTGQLAD
                     QLTGLAAQLGGELRPSDMARGLIAWTQLFGMVSFELFGHLVGSADPADPFFAHAVEEMA
                     DFLGLPEAP"
     misc_feature    complement(23492..23506)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.68"
                     /tool="antismash"
     gene            23560..24000
                     /locus_tag="C7M71_RS08530"
                     /old_locus_tag="C7M71_008530"
     CDS             23560..24000
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241302.1"
                     /locus_tag="C7M71_RS08530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C7M71_008530"
                     /product="nitroreductase/quinone reductase family protein"
                     /protein_id="WP_111489975.1"
                     /transl_table=11
                     /translation="MPTTALGRLAGDLTNRLVAALTRAGLSVWGSRVLAVRGRSSGEWR
                     TTPVNLLTHQGERYLVAPRGHTQWVRNIRVSGGGELRLGRRAEPFRVAELADTEKPAVL
                     RAYLRRWKFEVGVFFDGIGPDASDAELLRIAPGYPVFRVLDR"
     misc_feature    24658..24667
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    25252..25261
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 catgacgtcc gtgtaaccct ccaccaccac cgcccggccc gacttggcga tctccttctt
       61 cgccaggtcg atgccgtaga gcacatgcga cttcttgtag atcgcggtct cgggggtgtt
      121 gaggtacttg ggcccgttgt cgtcctcgcg cagccggcgg gcgccgaaac ccaccacctc
      181 gccggtgatg tcgcggatcg gccagaccag gcggccccga aagcggtcga tcaggccgcc
      241 ccgctgcccc tgcgaggcca ggccgccgcc caggatctcc cggtcggcga acccccggcc
      301 gcgcaggaac cgcaccaggt gctcccagcc caccggggcg tagcccaccc cgaagtgctt
      361 ggccgccgcc gcgtcgaagc cgcgctcgcc caggaagcgg cggccgatct ccgcctcggg
      421 gctctccagc tgctcggcga accaggcggc ggccaccttg tgcgcctcca ccagccgggt
      481 ccgctccccc ttctgccgac cgggggtgta gccgccctcc tcgtagcgca gggtgatccc
      541 ggcctgggcc gcgagccgct ccacggcctc ggtgaaggag aggtgctcca ccttcatcac
      601 aaagtcgagg gtgtcccccc cggcctggca gccgaagcag tggtacacgc ccttgctggg
      661 gttgacgtag aacgacgccg acttctcgtc gtggaacggg cagacaccct tgagctgcgc
      721 gccgccgccg ctgaccagct ggacgtagtc ggagacgacc gcgtcgatgg gcagcgcgct
      781 gcgcaccgtc tgtacgtcct cgtccctgat ccggcctgcc acccaggcag tctacggcgg
      841 cggccccacg cccccgaccg gcgtcgcccc cgatcggcgc tcagcccggc agcgcgtcca
      901 gcggcacccc cgggtcggcc agccgctccg ggtccaccgg ccgccgggag cggaccagcc
      961 gctggatcgg gtcggtgacg tcccacacat tgacgttcat cccggccagc acccggttct
     1021 cgccgtccag ccagaaggcg atgaactcgc gcttgcccgc gtccccccgg atcaccacct
     1081 gggcgtactc ccccggcgcg gcgtagcccg agtactccat gcccaggtcg tactggtcgc
     1141 tgaagaagta cggcagccgg tcgtagacca cctcccggcc cagcatcgcc cgggcggcgg
     1201 ccgggccgcc gttgagggcg ttggcccagt gctcgacccg cagccgccga ccgaagaccg
     1261 ggtggtacgc ggaggccagg tcgcccgccg cgaagacatc cgggtcggcg gtgcgcagcg
     1321 aggcgtccac ggcgaccccg ccgccctcct cccggggtgc gatctccagt ccggccgcct
     1381 cggcgagggc ggtgtccggg gcggcgccga tgccgatcag catggcgtgt gcgggcagtt
     1441 cctcgccggt gtcggtgagg gcggccagca ccatcccgtc ctggccgacc acctcggtga
     1501 tcgaggcgcc cagctggaag gagacaccgc ggtcccggtg caggtcggcg aagaagccgc
     1561 ccagctcggg gccgagcacc ccgtacagcg gggtgggctg cggctcgacc acggtcacct
     1621 cggctccata gccgcgcgcc gccgccgcga cctccaggcc gatccagccc gcgccgacga
     1681 tcagcagctg cccgttctcc cggcccaggt tccgcagcac cgcccgcagc cgctcggcgt
     1741 gcggcagccg ccgcaggtag tggaccccgg ccaggtcggc gccgggtacc cggagggggc
     1801 gcggcgagga gccggtggcc agcagcagct tctggtagcg gatggccgtg ccgtccccca
     1861 gccggacctc cttggcctcc cggtccaggg cggtcaccgg ctggcccagg tgcagttcca
     1921 cctcgtgggc ggtgtaccag gaggggtcgt ggacccggag ggcgtcgcgc tcctcggcgc
     1981 cggtgaggaa cttcttggag agccccggcc gctcgtacgg cttctcccgc tcgtcgccga
     2041 gcagtatcac ccgcccggtg aagccctccg agcgcagggt ctccgccgcc ttggcaccgg
     2101 ccaggccggc gcccacgatg acatgggtct cgttggtgtc caccacgtcc gctctctcct
     2161 gttccgcggc gggcggatgc cgccacgcac cgtgagtgcc aggttactgc gccgccgggg
     2221 ctggggccgg ggcccaacgg gccgttcgat gcggtcgagc gtcccccatg cggtcgcgta
     2281 cgtgaagagt gctgcgtgac cgatctcggc tcagcgctcc cgtaccagcg tgcggtgcag
     2341 cgccagcgcg gaggcgtcgg tcagcgaggc gatctggtcg accaccgcgc gcagccgcgc
     2401 ccggtcgtcc gccgcctcct cgaagagggc cctgaagagc gggtccagcc cgtgcggtgc
     2461 gtcccggacc agcacctcgg ccagctccgc gatcaccacc cgctgccggg agcgcagctc
     2521 ggcctgctcg gcgcgctgca tcacatagcg gaccgcgacc gccttgagca cggcgcactc
     2581 cagccgggtg gcgtacggca ccaccagctc ggcccggtag cgggtcagcc gccccgggcc
     2641 gtagcgctcc cgggtggccc gctcggcggc caggcagaag cggccgatca gctggctggt
     2701 ggcgtccttg agccgcgacc ggtcgcgggc cgatccgtcg taggtgtgcg gccaccactc
     2761 ctgcgcctga agccggtcca gcgcctcgcc gagctcctcg ggctccgcgc ccggcgcatg
     2821 acgggccgcc acccggaaca gctccgcccg ctcgtcccgg tcgcccagcg cggccgggtc
     2881 gacatggccg gcgtgcaggc cgtcctccac gtcgtgcacc gagtaggcga catcgtcgga
     2941 ccagtccatc accgtcgcct cgaagcaccg ccgcccgggc ggcgcggcgg cccgcaccca
     3001 gcggaagacc gccaggtcct ccgcgtagac gccgtacttc cgcgaccccg gctcggtcgg
     3061 gtgctcgccg cgcacccagg ggtacttggt ggcggcgtcc agcgcggccc gggtgaggtt
     3121 cagccccacg ctgcggcccg gccagggcgc cagccgggcc ggggcctcct cggccggggc
     3181 gaaccgcttg ggttccagca gggtcaggat ccgcagcgac tgcgcattgc cctcgaagcc
     3241 cccgcacccc tcggcagcct ggtcaagcgc cgactccccg gtgtgcccga acggcggatg
     3301 ccccaggtcg tgtgccaggc aggccgtctc caccaggtcc ggatcgcatc cgagcgccgc
     3361 ccccagttcc cgccccacct gggcgcactc cagcgaatgg gtcagccggg tccgggggaa
     3421 gtcgctgagc atcggcgcca ccacctgcgt cgtcccggcg agccgccgca gcgcggcgga
     3481 gtgcagcacc cgcgcccggt cgcgctgaaa cgccgtccgc ccgggcctct tgtccggctc
     3541 gggcacccac cgcgcctcgg cggcgggatc gtacgcgggc tcgaccgcaa gggcctgatc
     3601 ggtgtcatcc atataccggc aaccgtacgc ccggcccccg acaccccggc ccagcgccgc
     3661 gcggaccgcc gccgcccggc gcgagattcg gcggcgggcc aggctcctcc atgagcgggc
     3721 gccgccacgg ccgggagacc atcgcctgcg ccatggacga gccggacgcg gacgcctccg
     3781 gggtgctgcg gcccggcgga cgccgggtgg acgcggtctt ccggcgttct gcccgttctg
     3841 cgtggagctc ggctcgtaca tcgcggcata gctgacgggc catcatacgg cggggtgctc
     3901 tcggccgccg ccgcactgga ccgggtcgcg gaccatccgg cggtacgcca ggtggcgggc
     3961 ttcgaggagt accggaccgg gccgggtctg ccggtgaagg ccgggcaggt ggcggcccgc
     4021 ttcatcctgc acgggcccga ccacccgtcc gtcctgcgga cggcggagca gatcctgcgg
     4081 ggactggagc aggatctggg catcgggctg ctgatcggcg agaaggactg actgaccatg
     4141 accactgccc ccacctcagg caccggcgag ctgtccggcg ccctcagcgg cccccgcgtc
     4201 gccaccgtcg cggaacggca cggcaccccg gtgtggatgt acgacgccgc ccgtatccgc
     4261 gcccagatcg cccggctgcg gcagttcgac gtgatccgct tcgcccagaa ggcctgctcc
     4321 aacatccaca tcctgcggct gatgcgggag gagggcgtac tcgtcgacgc ggtctcggtc
     4381 ggggaggtcg aacgggcgct ggccgccggc tacaccgtcg gcgggcccga ggagccggtg
     4441 gtcttcaccg ccgacctgct ggaccgcgcc accctgcggc gggtggtgga gctgggcatc
     4501 ccggtcaacg ccgggtcacc gcagatgctg gaccaggtgg gccgggccgc acccggccac
     4561 ccggtgtgga tccggatcaa cccgggcttc ggccacggcc acagccgcaa gaccaacacc
     4621 ggcggcgagc acagcaagca cggtatctgg cacgagtacc tggcggagag cctggagctg
     4681 gtggaccgcc accggctgga cctggtcggc ctccatatgc acatcggctc cggggtcgac
     4741 tacctccacc tggagcaggt ctgcgagacc atggtcaagc aggtccggct gaccgggcgg
     4801 gacgtgcgcg ccatctcggc cggcggcggg ctctccgtgc cgtaccggcc gggcgacccg
     4861 gaggtggaca ccgaccggta cttccggctc tgggacgccg cccggcagga gctggtctcc
     4921 gaactcggcc acccggtgcg gctggagatc gaaccgggcc gcttcctggt ggccggctcc
     4981 ggggtgctgg ccgccgaggt acgggccgac aagcccatgg gcggcaacca cttcgtgctg
     5041 gtggacgccg gcttcaacga cctgatgcgg cccgccatgt acggcagcag ccaccgcgtc
     5101 tcggtgctgg cgcccggtgg cgcggtgcgc ggcgaggcgc tgcgggacac cgtgctggcc
     5161 gggccgctct gcgagtccgg ggatgtcttc acccaggtcg agggcggcga tgtacagccg
     5221 atcccgctgc cccgggccga gatcggcgac ctggtggtct tccatgacac cggcgcctac
     5281 ggcgccagca tgtcctccac ctacaactcc cgcccgctga tccccgaggt cctggtggac
     5341 ggcgaccgca cccggctgat ccgccgccgc cagaccgtcc aggaactgct ggccctggag
     5401 accgaggtct aggcccagca cccagctcgt tgacgctccc cagcaccccc gctgcccgcc
     5461 gcccgccgcc cgccgcccgc cgcccgagac cggaccgcca caacgcgtgc gtggcgtgtc
     5521 aggccatccc gcctcggccg ggtggtcctt cgtggtcctg ggctgtccgg tgcaggtcag
     5581 tccatgaccg gccagtccca gggacggggt ccgtgatggc cctggaggca ttccaggcgg
     5641 tggcgagcgc ggtccgccat gccggggtgg tccgaggcgt actggagggc aaagagtgtg
     5701 acgcgcagtt cgcggactcc gcgcaggatc gggaagccct tccatgaagt gacgtcatat
     5761 ccgtatgcac gggtgtactg ctcgtattcg gccgtgctga cgtgtgcgaa cagatcgcga
     5821 ccggcggctg tggaggtcag gtcccattcc ggggggccga tggcgcagcg ttcgaggtca
     5881 aggagatgag gggtgccatc cggggtgacg gcgaggttgc cgatccaggc gtcaccgtgg
     5941 atcacgcagt gtggtctgcc ctgaggcagg tgctcccatt cgacgtggag tcggcggagg
     6001 tgtgcgcgca gccagtcctg ctcggcggtg tcgatgatgt cggcggctgc cgcggtggcg
     6061 atgcgggcgt caagtcgtac gaacgggtcg agtggaccga tgatcccggt ggtggggggc
     6121 tggagggagt gcaggcggcg gagtacggac gcggtctcag cgggggtgcc gcgcctgtgc
     6181 gggggcagtt cgtgccagta ggtgatgctg tggccgcgga cctcgaccgg ctgctcgaca
     6241 tccagtggtc gcaccgcagg caggccgaca tccgagagcc agcgggcgac agcgatctcc
     6301 ttgcgggcgg cagcctgctg gccgggtctg gcaatacggg cgacgacttc gccgggaagc
     6361 cgccagacgg cgttctctcc gaggcggatc ggctcccccg gctcaaccgg caggccgagc
     6421 cgaccggatg cctcacggag gatggacaga ctgcgttctc gtgcctgggc gatgctcacg
     6481 cttgggtcac ggccacgacg atgcgctccc gaagatggtc gaccgccgcg ttcccctggt
     6541 gcgggtctgc gagctggtga agtacgcgca tatcgtctgc ggccctccgg gaccgcagcc
     6601 ggccgatttc ggccagcgcc gtggttccga cgactgacgc ttcctcaggg tcacctgtcg
     6661 ccatcagcac agtggcgatc ctgccgcggg atagggcccg ggagcggacg acgttcgagg
     6721 tgtggccgtc gactgcggtc tgcaggcggg tgacggcctc cttcgcgggg ccgccgtaca
     6781 gcgcgatgtc gcagagagcg tgcccggtgt cgccgtggtg ctgagcgtgg tcgtagaagt
     6841 tcatccatac cgggatcggc tctcggccgg ggtcatggtg tgcccaggcg tcgtccgagg
     6901 cgccgacggc ggcgagggtg tcctggaggc ggcccatctt cgcgagtccg cgggcgcacg
     6961 cgttgtacag ccaggcacgc tccacgggca ggagccgatc ggcgcgagcc agacccagct
     7021 cggcgtaggt cagccccaac tgcaagttgc cgcaccaggt ctcctgacgg gagcgccagg
     7081 agagggcgtg ggcgcgcaag ccccagtttc ctgcttcctc ggcacaggtg gtcgccaatg
     7141 acaagacctt gcgcgcgtcg tcgtgggcat aggagtcgaa agccgctgca ccgatcacca
     7201 ccgcaagtag cccgacagcg gtgagcaatt ggggacgcaa cgacgaggtg cagcgtctgt
     7261 ccagaagcct caccgcccat cccagctggg cgatggcagc gtcccggacg atgccgcctc
     7321 cgccgtagcg cccgtccagc cccttcaggg cagctgcggc tgcgtgaacg tggtccacgt
     7381 cctctgaccg gacttcctcg ggaagaggac tgcgccccag tgactcgacc agcgccagca
     7441 tggttccagg ggtcagtgct gccacgccac cagcgccaat aaaggttcgt cggtccacag
     7501 gcagctcgct tccgaacggc ggaaccccca tcatgcgccc gatcccggcg gtagcaaaag
     7561 ccggggctga gaccgtgcct ggccggggac tgttcgccag cagctcaccg gccccaagca
     7621 gttcctcgac agagatgccc aggaccttgg caatggaggg tagccaccga gtagggcgaa
     7681 cgcgtcccgt ctcccagcgg tagagcgcgc tgcggtccac actgcccggc actgtgccgt
     7741 tggccgcgct attgagcaga gtcacgaact cggttgtggt ccagcctctc gcagcgcgtt
     7801 cggctcggat gcgtgccccg agagcctggc ggggtgtcgg tccgttggcg ggcgggacgc
     7861 tgtcctcgga aggcatggca atcaccagac ccgagcgagg cggacgcata ccggccgccg
     7921 gcccatgccg acgtcgagag cttccggagc gttcgcgagg acgcgagcga cgccaggagc
     7981 cgaggtgtcg cagcagtgcg cgaactgggc agggagccgc cctaagagtg tgccctgcat
     8041 cttcgtcatg cccaatgctc caccgtgcct acacgtgcat acacatctgc atacgtccgt
     8101 acagcagcca acacagtcgg aggggcggtt aggtactgcc aggtggccgg gtctaccggc
     8161 atccgtcagt cgagaggccc gccagccatg accagcccca tctgcgcgcc cgtggtgccg
     8221 cctgcgccag ctgagcctac gtgtgcagtg atccacgtgc ggcccatttg cggtgatcgg
     8281 cccgatcggg catggactga tccgcccgca cccgcctcag ggcgtaatgg cgtgattaca
     8341 ctccggcgcg gccggcgccg gatctacctc ggcccgcgat gcggtgacca accaacagat
     8401 gcattgcagg aaggactttc tccatgactg acgtgaccgc cgaccctgat cgggccgctc
     8461 aactgcgcga ccagatcgtc gataccctca tcgcggacgg cacgatcgtc tcgaaaccgg
     8521 tcgagaccgc gatgcgtgcg gtcccccggc accagttcgc cccggacgcg tccatggacg
     8581 aggtgtacag cgcctacaac gccgtgttca ccaagaagga cgagcacggg gtcatcatga
     8641 gttcggtgtc ggcaccgcag atccaggcga tgatgctgga gcaggccggg atcgagccgg
     8701 gcatgcgggt gctggaggtc ggctcgggcg gatacaacgc ggccttgatc gccgagctgg
     8761 tgggtgcttc cggcgaggtg acgacggtcg acatcgaccc tgaggtcacg gatcgggctg
     8821 ctcgtctgct ggcgggcgcc ggctacaccc gtgtccgtgt ggtctgcgcg gacgccacgg
     8881 acggtgttcc cgcgtacggc ctgtacgaca ggatcgtggt gacggccggt gcctgggaca
     8941 tcccgccggc ctgggtgtcc cagctgaccg ccggcgggcg gctggtagtg ccgctgcgga
     9001 tgcgggggct gacccggtcg atcgccttcg accgcgccgg tgaccacctg accagcgtct
     9061 cggcgcaggt gtgcgggttc gtgccgatgc agggcgcggg cgcgcaccgt gaggagttgc
     9121 tgctggtcac cggtacgggc gagatcgggc tgcgcttcga cgacggactg cccgcagacc
     9181 ccagccgcct ggacaacgcg gtgcgcacgc cgcgggcgga gacctggagc ggcgtgctga
     9241 tcgggcggca ggagccgttc gacacgctcc agctgtacct ggccacggtc ctggacggct
     9301 tctgcatcat ggccgtcgac ccggatctgg ataccggtct ggtggcgccg gcgaacaggt
     9361 ggttctgcat ggccgccgtc gacggcggca gtttcgccta cgtcaccacc cgccgcactg
     9421 ccgacgaggc gtcggtcgag ttcggcgtgc atgccctcgg gcccgacgcc gtcgcgctcg
     9481 ccgagcgcgt cgccgagcag atccgcacct gggaacggga gcgccgcagc ggccccggcc
     9541 cggtgatccg cgtctacccg gccgacaccc ccgatgacca gctgcccgac gggcgggtca
     9601 tcgacaagca gcactgccgg atctccatct cctggcctgc ggcgaccgcc gcctaggcca
     9661 ggcgtcctgc accacccacc gagaagaaga acaggagagt gatcgagatg gcggacaccc
     9721 gcgtctcggg cggcgccacg gcgctggccg agcggcccgc tgccgacggc gccttcgccg
     9781 acgagttctc gctcgacgtg agggtcgtcg tcgccgccca tcccaacggc aagctcgcgt
     9841 gctccacgag tgacggctgc ggctcctcct gcagcggaag cgcctgcacc agcttcaccg
     9901 acgacccggt ctgacgggtc cgacgccggt ggtgtgccgg gcggtccccg cccggcacac
     9961 caccggtacc cggcagcacg cgttcccagg ggaggggccg atggcatcga gttcaccgct
    10021 gcgctaccgg tggcggggcg gcgcgatact gcgcgccacc accgatccgg gggacctggg
    10081 tctgcccggt gatctggacc tgtgcggcga cgccggcgcg gcgcgggccc ggggatggct
    10141 aggccaggtg tggcggcgcg aggacgtccg cgacgccctg agcgcggcca gccccgtcct
    10201 gtgccgccag gtcgacgccg tcctggccga cgcgtcctgc ggggcacggc agctgcgccg
    10261 gaccgtgctc tcggtcgcct cctacctgct gcgctggcag cgccgcccca cgcctttcgc
    10321 cctgttcgcc ggcgtcgccg ccgcgcggat cggctccgtg ccccgtgcct cctggggaac
    10381 cgggcacacc gcgttcgtgc ggcccgacgc ggagtggctg gcggatgtca tcgggtgcct
    10441 ggagcagcat cccgacctgc tgcgccggct gccggtggtc gtcaacgacg cggggcggat
    10501 gcgcgggggc cgcttcgtgg tcccgggggc gccagcggat gggcgtgccc acctgctcgc
    10561 ccccctggag gtctcggtcg gtgtgacccg accggtctgc gcggtgctgg acgctgcccg
    10621 ggccccgatc ccgtacgacg acctgcgctc cctgctcgta agccggttcc ccgccgctgc
    10681 gccgcagcag gtcgactccg tgctgcgcgg gctgatcact cagaacatgc tgatcaccag
    10741 cctgtggccg ccgatgaccc acctggacgg cctggggcac ctgtgccggg agctcgaagc
    10801 cgccggggcc gagacggtcg gggcggtcgc ggacctggtg cgcaggctgt atgagatccg
    10861 cgacggactc gccgaccagg acccgacggc tgcgtggtcg gcccgtgccg ggctgatcga
    10921 gcggatgaac gcggtcagca cggtcacgcc ggtgccactg atcgtcgaca ccgccctgga
    10981 ctgcgacata gagatccccg agcaggtggt ccaggaggcg caggaggcgg cctgcgtcat
    11041 gtaccggctc accccgcagc cgttcgggta ccagcagtgg cgcgattacc accgcgcgtt
    11101 ccgcgcccgg tacgggaccg gcgcgctggt ccccgtcctg gacctggtcg ccgacagcgg
    11161 cctcggcctg cccgccgact accagggcgc cgcgctgggc cgcccgcccc ggcaggtgac
    11221 cgagcgcgac gagaagctcc tcgccctgat ccagcaggcc ctgctggagc ggcgcgagga
    11281 gatcgtcctg accaaggagg tgattgcgga cctggccctc ggccaggacg ctgagctgat
    11341 ccccgtgccg agggtcgaga tcgcggtcga gatccacgcc gcctccctgg aagccctcgc
    11401 gcggggggcg ttccgcctgg tggtgaccgg ggcgccgcgg ccgggagcca gcatggccgg
    11461 ccgcttcacc cacctgctgc ccgaaccgga ccaggccgcg gtcgccgcca cctacgagac
    11521 cgccgacccc ggggtggtcg ccgcgcagtt gtcgttcgcg ccgaggcgcc gccgcaccga
    11581 gaacatcatc cgcacccggc aggtcctgcc ccacgtcatc ccggtcagcg agcaccgcgc
    11641 cgataccgac ggcgtgatcg gtcttgcgga cctggcggtc accgcggacg cccgcgcctt
    11701 ccagctcgtg cagatgtcca ccgggcgcct cgtggaaccg cgggtcgcgc acgcgctgga
    11761 ggccggtgtg cacacccctg ccctggcccg gttcctcgca gagatcacca ccgcccggtc
    11821 ggccgcctac aagggcttcg acttcggagc ggccgtccat ctgccctacc tgccgcgggt
    11881 gcgctaccgc agcaccgtgc tctcccctgc ccgctggatg ctcagatccc aggacctgcc
    11941 cagccacggt gccgcaacca ccgagtggga caaggcgctt acggcgtggc ggggcaggct
    12001 gcgggtacct gagcgggtga cggtcgtcga cgacgaccag cggctcccgc tggacctcga
    12061 ccactcgctg caccggatga tgctgcgccg cagcctggat gccgccggac gcctcgaact
    12121 gggcgaggca ccggctcccg acgcggtggc ctggctcggc cgcccccacg aactgctcct
    12181 gcccctgacc ctggagacgc ctctcgcccc cagacggcca accgggccgc tccgccgcgt
    12241 cgcgggcgac gccgcccaac tgccggggcg cggccaggtg ctggcggtgc atctgtcagc
    12301 ccatccggcc cgctacgacg agatcctcac ccaccacctg ccgagctggc tcgaccccgc
    12361 cgagcggtgg tggttccggc gccaccgcga cctggcccgc ccggacgccg accagtacct
    12421 cgccctctac ctgtcgctgc cccacccgga cgcgtacggg caggtcgcgc ggcgcgtcag
    12481 cgactgggcg gccgaactgc gccgccgaca cctggcctcc cacctggccc tggccaccta
    12541 cgagccccag acgggacgct acggccacgg cgcggcgatg gacgccgcgc acatcgtgtt
    12601 cgtcgcggac tccgccgcgg cgctcgccca gatccgcctg gccgaaaagg ctggagtccc
    12661 agcgcaggca ctggcagcgg ccggcatggt cgacctcgcc gcccgcttcg ccgcctcccc
    12721 cacgcagggc ctgcactggc tggtggagaa cctgccccgc gagcacggcc cgctggacca
    12781 ggctctgcgt gaccagaccc tggccctcgc ggacccgtac gaaccgtccg ccggcgtgcg
    12841 ggagctgccc ggcggcggcg acctggcagc cgcatggcag acccgggcat cggccctggc
    12901 cgcctaccgg gagcatctga aggtcgagcg cgacccgctg accgtccttc ggtccctcct
    12961 gcaccagcac cacgtgcgct ccctcagcgt cgatccggac gacgaacgcg ccaccggccg
    13021 tctggtcagg gcgtgcgcgc tgcgccacac ctctcgccgg gatggcgtcc gatgagcacg
    13081 ccgccccggc cgcccgccgc cccggccgac ctggtggagc tgttcgccgc ggccctggac
    13141 cggcccgcac caccaccgcc gcacgaacct tggcaggcgc actccctcgc cgagggcgcc
    13201 gccgggatcg ccctgctcca cctccaacgc gcctacaccg gccacggaac ctggcagcag
    13261 gcgcacgcct ggatcacgac cgcagccagc ggcgacatca gcgccgccga caacaccggt
    13321 ctgttcctcg gcgtgcccgc cctcgccttt ctgctgcacg ccgccaccgg ctccccagcc
    13381 cgctacgagg agtccctggc cacgctcgac ctccacgtcg ccgccctcgc ccggcgccgc
    13441 agcgccgccg ccctcgcccg catcacccga ggccaactcc cggcgttcgc cgagtacgac
    13501 atcttctacg gcctcaccgg catcggcgcc tatctgctgc gccgcgaccc ggtcggcacc
    13561 gcgctggagc aggtcctgga ctatctcgtc gcgctcaccc gcccgctgcg ggccgacggc
    13621 caccaactgc ccggctggtg ggtcgcccat gacccgcacg gccgaatgtc ctcccgctac
    13681 gccggggggc atggcaacct cggcgccgcc cacggaatca ccggcgtcct tctgctcttg
    13741 agccaggccg cgcgccgccg cgtcaccgtc gccggtcagc tcgacgccat cgccgccctg
    13801 tgcgcctggc tgacggcatg gagacaggag gggacgagcg ggccatggtg gccggagcac
    13861 ctgtcgccgg ccgacctgcg caccgggacg acgcaccaat ccggacccgg ccgcccgagc
    13921 tggtgctacg gcacccccgg catcgcccgc gccggtcagc tcgccgccat cgcactccat
    13981 gaccaccagc tccaacgcga gttcgaggac gcgctcaccg cctgcgtcca tgaccccgcg
    14041 cagctggacc agatcaccga caccggcctg tgccacggct gggcgggcct gtaccagacg
    14101 gtgtggcgtg cgtcccgcga cgctctcacc ccagccctgc gcgcacgcct gcccggcctg
    14161 gccaaagcgc tggctcgcca cgcccgccca ggcaccgccg gtcccggctt cctcgacggc
    14221 gacgcgggga ccgccctcgc cctgaccacg gccgccaacg acgcggcacc gacctgcgga
    14281 tgggacgcat gcctgctgat cgactgacct cgcccccggc cgtgccgtcg gcccggctac
    14341 cggccggcgt cccggagacg gcgcgggccg tccgggaggt cctggccggt accccgcttg
    14401 gtgaagccgc tctccgggcg gacctggacc cggccgaact ggcaacggcc gtcgagctct
    14461 tcacgaccgc cggccgccga gcgctcgccg agcagcacgg cgcccacagc cggtggacgc
    14521 agctctacct ggagttcacc cactgggcga gcgcggaaaa gacggccgcc gagcacctgg
    14581 caccgctgct gcacaccgcg cagcggcagg gcgatctcac cggctggtgg ttcatccgca
    14641 agcacccctg ctggaggctg cgcctgcgaa cctcccacga cgccgcgaag gccagcgtgc
    14701 cggctgcgct ggacggcctc gtcactgcgg ggcatctgcg gcgctggtgg ccgggcatca
    14761 tctacgaggc ggagacaccg gccttcggcg gcggcgccgc catgacggtc gcccacgagc
    14821 tgttcaccgc ggacagcacc ggcatcctgg ccctgacccg ccgcggtgac cgtgcgctcg
    14881 gccgtcgcga gctgtccgtc ctgctgtgca cgacgctgat gcgcgccgcc gccctggagt
    14941 ggtacgagca gggcgacgcc tggcaccgcg tcagcgagga ccgccccctt ccctccgatg
    15001 tcccgccgga ccggctccag gagctggccg ggaacatcgc cacgctcctg cgcgccgact
    15061 tcgcccccga cggcccgctg tggggccccg gcggaccggc ggagttcgcc gccgactggg
    15121 ccggcgcctt ccgccgagcg ggacaggacc tcggggcagc ggcccgcacc gggacgctgg
    15181 agcgcggact gcgccacgtc ctggcgtacc acgtgatctt ccactggaac cgcctcggcc
    15241 tgccgctgca cacccagagc gtcctgtcgt gggcggcccg cgccgcgata ctcgacgcgc
    15301 ccgcctcccc cgcccctccg gcaccgggcc ccggactcca gcgggagggc acatgaccgg
    15361 gtcggagcac cgccggccgg gcagcgagct gccggatgcg gcccgccggg tggtcgcccg
    15421 gtttccgctg gtgtcccgcc cccgcctgac ctgccccgac ctggcgacgc ggatcggcga
    15481 agtgcgcgag cacgccctcg ccgccgagca ggatccggac ccggctgccc ggcgacaccg
    15541 ggcctgcgcc gcctggaacc tggcagcgct gatcgccgcg gactgcggca tgcccgccta
    15601 cgccgcgcag ctgtgcgagc agcagttcca cctcttgcgc gcctcctggc cgacgaccgg
    15661 cccggcctcg atcgcctccc tccagccgct ggtcaacctc gcccggctca cccaccgtgc
    15721 cggggacccg tacggcgcat atcaggcgct gctcggcctg gacgaagccg tgaaccacgg
    15781 cggaagcgtc ccggtagcag gcatgcctgt gcccttcgac gccttcgccg cgaccgatcg
    15841 ggaccgaagc caggccgcgg agtggctgcg gatcctcgtc cgccaggacg gtccccgctt
    15901 cctggccgcc gccggccggt gggacaccgc cgctgaacgc accatgctcg acggccccga
    15961 cggcgggcgg ctacgcgaag gccgccaagt ccacgtgatc gcccacctgc tcaccggacg
    16021 cacccgcacc gcgctcgcgc tcctggagat cagcctggtc aacaagccgt gggaagaagc
    16081 cgtcgcggag tgcctgcaca cgctcgcact gctgctcgac gagcacctca cccgccggga
    16141 cgccgaacgg ctgctggccg cgttccacgc cctccgggaa ccggtacccc gtccggacac
    16201 cggcgccttc cggacccggc tcggcctggc cgtggccgac ctcatggccg gcccatgccc
    16261 gcagcaggca gacctgctgc acggcgagct gatccgagac gcccagggca gcgacgacgc
    16321 cttcaccgcc cgggacctcc tgggccaccc cggggcacgc ggacggatga ctcccggcga
    16381 agccggcacg ctcaccctca tggtgagcaa cgccggcctc gaccacggct cgatcccgca
    16441 gccgctgctc ggcctactgc ggacagcgac ccagagagcc gagaccgtcc tcacccgggt
    16501 ccttgcccgt gggtctagcc cccggccccc gccgggaggg ggcggccagg aactccggtg
    16561 cgggtgggga tgcgtttctg ggaagatatg tgggccctca cggcatgatc ccagcccgac
    16621 ccctcgcaca ggagactccc gacatggcgt tgccgcaggg acctctcgat caccgctacc
    16681 gaggcgagca ccccgtccgc accctcgcct atctgctcca ccaggaccgg ggacggctgg
    16741 cgctggccgt gctcgcgttc ctgatcaagc acagcccgac ctggctcacc ccgctgatca
    16801 ccgccaatgt catcgatgtc gtggtgcagc accggcccat cacccagctg tggctgggcg
    16861 ccgggctgct gctggtgatg ctggtgctca actatccgtt ccagctggtc tacatccgct
    16921 gctggtacgg cagcgcccgc cggatgggca cccggatgcg gaccgcgctc tgccaccgga
    16981 tgcagcagct ctccatcggc taccactccc gggtgagcgc cggggtgctc cagaccaagg
    17041 tgatccgcga tgtggagagc gtcgagcagg cgttccagca gaccggcgac ctggggctgt
    17101 cggcgctggc cacgctcacc ggggcgctgg tggtgatcgg ggtgcgggcg cccgcgttcc
    17161 tgccggtctt cctggtggtg gtgccggccg cgtcggcgct ggtgatgtgg ctgcgcgggc
    17221 ggctgcgcgc atacaacgag tcgttccggc aggaggtgga gcagctctcg tcgcgggtga
    17281 gcgagatgac caccctgata ccgatcaccc gggcgcacgg cctggagcac accgcgctgc
    17341 gccgggtgga cggcaccctg cggcaggtgc tgacggcggg tctgcggctg gaccggctca
    17401 atgggcagtt cggggcgctg gcctggatca tgctcaatgc gctgggggtg ggctgcctgg
    17461 ccggctccgc gctggccgcg tactacggct ggctggccgt cacccccggc gatgtggtga
    17521 tgctcagcgc gtacttctcc gccctgacgg cggcggtgac cacgctgatg gggctgaccc
    17581 cggtgatcag caagggcctg gagtcggtgc ggtccgcggg cgaggtgctg gaggcgccgg
    17641 acctggagca gaacgcgggc aaggcccagg tggccgaggt gcgcggccgg gtggacttcc
    17701 agggcgtcgg ctatgcgtac gacgacgcgg agcggcattc ggtgcgggac ttcaccctct
    17761 cggtgcggcc cggcgagacc atcgccctgg tcggcgcctc gggcgcgggc aagtccacgg
    17821 cgctcaacct ggtgaccggc ttcctgcggc ccaccgaggg ccggatcctg ctggacggcg
    17881 ccgacatgga gtccctggac ctgcgtagct accggcggtt cctgtcggtg gtgccgcagg
    17941 agtcgatcct cttcgagggc accatccggg agaacgtcac ctacgggatg tcggatgtct
    18001 ccgaggagcg ggtacgggcg gcgctgcgcg acgccaatgc gctggagttc atcgagcggc
    18061 tgccgaccgg gctgggcacg gtggtcggcg agcgcggggc ccggctgtcg ggcggtcaga
    18121 agcagcggct ggccatcgcg cgggcgctga tccgggaccc ccgggtgctg gtgctggacg
    18181 aggccacctc ggcgctggac tcgcactccg aggcgctggt gcagcaggcg ctgtcccggc
    18241 tggtgcgcgg ccgtacggtc ttcgtggtgg cgcaccggct ctccaccatc cgcagcgccg
    18301 accggatcgt ggtgatgcac gacggccgga tcaccgaggt cggcacccat gagcagttgc
    18361 tgcgcagcgg cggggcgtat gcggggctcc aggcggcgca gtccgcctga tcgcggtgct
    18421 cagccgccga cctggaggag cacctgcgcc gtgtcggggt tgcccgaaac ggacacctgg
    18481 ccggtgacgg ggtagccggt gggtagcagc acgcccgtcc agcgggccac cccggtgctc
    18541 ggctcctcca ggccgcacat ccgcgacgcg cccagccacc cggtggaggt ctcggcccgc
    18601 agcgccaggc cgttggcctc catcgacgcg tccagcgtgg cgcgcgggac gcggtaggcg
    18661 aggtgcagcg gcaccttggc gccgccggcg ccaccggggt cggcgaggta gtggacgtcg
    18721 acggcgccgg cgggcagccg cactccgtac cgggcggtgg ccgagtccag gctctcggtg
    18781 ctgccggggc aggcccgcgc atcggtgccg tccggggcgg agagctgccg gtagagcagg
    18841 gtgccgacca ccgccgccag ggcgaccggc aggccgatca ccaccagcgg gccgagccag
    18901 cgcggcccgg ggccgggtgc ggccggctcc ggggcgggcg gggtgaggtc gatgaccgcc
    18961 tcggtgtcct gcggcccggc cccgcccatg tcgccggtca tgcccatcgc gcgcccctcg
    19021 ccgtccgacc ggcctgcggc cgggtgcgtc ccgatgctac tgacgcggcg gtgcgtcaga
    19081 gcagtgcgtc agaacgggcc ccgtaccgcc cgcagcaccg cgtcggccat gccgcgctcg
    19141 ccgcgctcat tggggtgggc gggcgcggcg ggggcagccg gggagagcgg ctcgatccag
    19201 cggaccgcct cggcggtgca ggcgtcgtgg cccagcgacg gcgtccaggt gtccacatag
    19261 cgcgccccgg ccgcctcggc ccgctgccgc agctcggtgt tgagccgctg ctcctcgtcg
    19321 tgcagaaagg cgacgtcccc ggcggccagc cccagctgcg aggggcacgc cgccccggac
    19381 tccggcacca gcgccgggta gcccaccacg aagacccggg ccagcggcgc ccgctgccgg
    19441 acctccgcca gcccggccgc cagccgccgc ccggccgtct gcacccgctg ccccagctca
    19501 tcgtggccgg aggcggtgta gaagtccttg cagggcgcgt caccggacgg cgctgcggac
    19561 cggtccaggc cgagggagcg cagcaccccc gcctggacgc agcggctgag cagggcgaca
    19621 aaccccacgt cattgccgcc gatgctgagc gtcaccagcc gggtccgggt ggacagcgcg
    19681 gcgagctgcg gcgggttgac accgtcggag gtggactgcg gggcggcgag gttggcggtg
    19741 gtggcgccgc tgcaactgac gtcgcggaag tcccggccgg tcaggcccag cgccttggcg
    19801 accagcgacg gatagttgcg gtcggagcgg tcgcagccca gcggggtgcc cgcctgggtg
    19861 gggatgcgcg gcccggaggt gtaggagtcg ccgagcgccg cataggggcc tgcggacgag
    19921 ccgctgccgg ggctcggcgc ggtggtggcc accggtacgg gggcgggctt ggcggggccc
    19981 gcctgggagc cgccgccgcc ggagcaggcg gcggtgagca gcagcgctcc ggtcgcggcc
    20041 agggcgccgg cggcggtccg caggtccttc ttctgcatcg gcgggctccc cgggggtcgg
    20101 gtcagggcgt gcgacggccc tctcctcgaa ccgtacgagc gtgcaacgtc cggcgcccgc
    20161 cggaggactc ccggcgggcg ccgtcggggg gacggcggga cggccgccgg gtcagtccgc
    20221 gccgtgctcc tgctcggcca ggaactcctc gaagcgccgc cccagctcgt cggcggacgg
    20281 cagctcggcc tgctcggcga gcaggctctc ccggctctcc gcgccggcca cggcgtcgta
    20341 ctggctctcc aggccacgga tggcggtggg cagctcgccg tcggtctggg ccagctgctc
    20401 gtcgatgtcc gcgcggacct cggtgacccg ctcgcgcagc tcggtaccgg gcagcaccag
    20461 gccggtcgcc gactgcaccg cctccagcac cgcgaccgcc gccgccggat aggccgaccg
    20521 ggcgacatag tgcgggacgt ggacggcgaa gccgagcaca tcgtggcccg cctccgcgag
    20581 tcggtactcc agcagcccct gggcgctgcc gggcacctgt gcctgctcga accagcgggg
    20641 gtgggcggcg gccaggtcga gccggttgcc gtgcggggtc aggcccaccg ggcgggtgtg
    20701 cggcacgccc atcgggatgc cgtggaagtc caccgcgagc cgcaccccga agcgggcgac
    20761 cagcccgcgt acggccgccg cgaaccgctc ccactcgaca tccggctcgg ggccgctcag
    20821 cagcaggaac ggcgtaccgg ccgcgtcgtg caccaggtgc agcaggatct ccggcggctc
    20881 gtacgccgac cagcggtcgc ggtcgaaggt catcgggggc cggcgtgccc ggtagtccac
    20941 cagccggtcg tggtcgaagc gggccaccac ctgcggctcg ccgtgctcca gcaggtgctc
    21001 caccacctgg gcgccggcct cgccggcgtc catgaagccc ccgaggtggt acagcaggac
    21061 cagcccgggc gactcggcgg cggtggcggc caccgcctcc acgccctccc gctccaggtc
    21121 gtacagagcc tccggatcac gcaccgtgca cccaattcct tccgtcccgg acgggtgccc
    21181 ggcgccatgc gcgcgggaac cctctctcgg gacacctcag cgtcacgggc ggccaccgca
    21241 ttcccctgcc cggccacctg gtccgtcccc gccgggattc cggcaaacgc gctggccaga
    21301 gggtgtgccc gggcggccgg ggccactggt cggtgcgcgg cggaatccgc gcgcccctct
    21361 cggcgtgccg agggatgacg cacggcccgc ggccctgtat cgtcctctcg ctgcccggct
    21421 tcgcacggcc gtggccagcc cctccccgca ccttgccttc atctggccgc ctgcttcctt
    21481 tcgcgcaccc gttcctgcct cggccatctc gcggacacac actgtcccct cccgctcccc
    21541 ccgccgggcc catgcgatcc gtcgccgacc ccggcatgcg ccgcacgccg caggggccgc
    21601 cgcaccgatc cgccaggccg gtgccggacc gcacctgcgc ggcggggcga ccgtccactc
    21661 cgcctcctcg ccgaaggacc gaaggcccgt gcccgtctcc gtcaccctca ccggccgcat
    21721 ggtgcggctg gagccgctca ccgagcggca cgccccggcc ctggccgccg ccgcggccga
    21781 ggaccgcacg gcgtatgcct tcacacccgt gccgcacgga ctgaaggccg cccgcgcgta
    21841 tgtcgcggcg gccctggccg accaggccgc cgggctcgcc atgcccttcg ccaccgtccg
    21901 ggtgtccgac gggctggtgg tcggctccac ccggttcgcc gagctggact actggcaggg
    21961 cccggtgctc tggccgcccg tgccgcgcgg cccgctgggc gacccgtacg ccgccgtgcc
    22021 cgacgccgcc gagatcggcg gcacctggct ctccgcccgc gcgcagggca ccgggatcaa
    22081 caccgaggcc aagctgctga tgctgcggca tgccttcgag acctgggggg tccgccggat
    22141 ctcgctccgc gccgacgccc gcaatctgcg ctcccgggcc gccatcgagc ggctgggcgc
    22201 ggtctgcgag ggcgtccgcc gggcccacac ccggggcctt gacgggctgg tccgggggac
    22261 ggccttctac tcgatcctgg acgaggagtg gccggccgta cgggacatca tcgagctgcg
    22321 gatcgcggcg gccgactccc caagcgcccc ggaccgcccg ctgaccgccg atcccggcct
    22381 gatcccggcc tgatcccggc ctgacctccg ccgcgcccga cctccgttct tcgggtacgg
    22441 cacactccgc cccggccagg gcgactacct gatccaccct ggccgggcac acccctccgc
    22501 cgtgcgcggg gacctgtcgg cggtgcccct ggcggagtac ccgggcgtgc cgggccgagc
    22561 cggacgcctt ggaggaccac cgggaggacg ggaccggcga ctagctacgg ccccgccgcc
    22621 gggtggcacc ggcggtcggc gagcgcggca ctggcggcgg actggctgcg ccgccgagtc
    22681 agggggcctc gggcagcccg aggaagtcgg ccatctcctc caccgcatgg gcgaagaacg
    22741 ggtccgccgg gtcggcggag ccgaccagat ggccgaagag ttcaaagctg accatgccga
    22801 agagctgcgt ccaggcgatc aggccgcgcg ccatgtcgga ggggcgcagc tcgcctccga
    22861 gctgcgcggc caggccggtc agctggtcgg cgagctgccc ggtggggacc cgggcggcgg
    22921 tctgcgggcc gggcccggcg gcgcgcacca cggcgaccag gaccagggcg accctggccg
    22981 ccgggccgat ggtggcctgc ggcgcctggt agccgggcac cggggtgccg tacaccagcg
    23041 cgtactcatg ggggtgctcg cgtgcccagt cccgtacggc gtggcagagg gcccgccagc
    23101 gggcgcggtg gtcgccgggc ggggcggcgg cgaccgctgc ctcggtccgc tcgcccaggg
    23161 cgttgtacgc gtcgatgatc agcgcggtca gcagttcgtc gcggctcggg aagtaccggt
    23221 agagcgcgga cgagaccatg cccagctcgc gggcgacggc gcgtagcgag agtcgctggg
    23281 cgccctcggc ggcgagctgc cggcgggcct cctccttgat ctccagggtg agttcctcgc
    23341 gggcccgctg ccgggcggta cggatggcgg ccatgggcgc agtctgccag agatcggagc
    23401 gtcgcacgca ttcgagagca ctgctcttga caacgctcgg agccgggtgc cactctcagg
    23461 gcagacgaaa cgagagcact gctctcggaa gtcgccgaaa ccatccaaag ggagcccgag
    23521 atgtccgacg ccaccacccc ccggcccgtc cgctatgtga tgccgaccac cgccctgggc
    23581 cgcctggccg gtgacctcac caaccgcctg gtggccgcgc tgaccagggc cgggctcagc
    23641 gtctggggct cccgggtgct ggcggtgcgc ggacgcagca gcggcgagtg gcgcaccacc
    23701 ccggtcaacc tgctgaccca ccagggcgag cgctatctgg tcgcgccgcg cggccacacc
    23761 cagtgggtgc gcaacatccg cgtctccggc ggcggggagc tgcggctggg ccgccgcgcc
    23821 gagcccttcc gggtggcgga gctggccgac accgagaagc ctgcggtgct gcgggcctac
    23881 ctccggcgct ggaagttcga ggtcggcgtc ttcttcgacg gcatcggccc ggacgcctcg
    23941 gacgccgagc tgctgcgtat cgcccccggc tacccggtct tccgggtcct cgaccgctga
    24001 agacccgctg aaccggacac ccggcgggca cctggcggac acccggcggg cagcggtcag
    24061 ggccggcccc cgcacggcgg ggaccggccc tggcgtcgct cagccggcct cggcgacccg
    24121 aggctcctcg gagaactcca tctccggcgg cgcggtgcgg aacatcccgg tcagataggc
    24181 caggtaggcc accccgagcc cgagccagat cagccccagc accagggcct tgccgtccag
    24241 gtgggccagc agccagaggt ccaccacggc cccgatcgcg ggcgcggcca catggcggag
    24301 cgcgccgagg tcgcggcccg cgcggcgttc gcggacgaag gtggcgatga cgctcacatt
    24361 gacgaaggtg aaggcggtga aggcgccgaa gttgatgaag gaggtggagg tggccacatt
    24421 gagccgcagc gcgatcagcc cgaccgcgcc ggtcagcagg atgttgaagg ccggggtccg
    24481 gaagcggggg tgcacatagc cgaacagctt gcgcggcagg acggagtcac ggcccatggc
    24541 gaagagcagc cgggaggtgc tggcctgggc ggcgatcccg gaggagaact gggcgaccac
    24601 caggcccgcg aggaagatcg aggagaagag gtcgccgccg atggtcttgg cgatctcgaa
    24661 ggcggccgag tccgggtcgg agaaggtgct gccggggtgg accagctggg tggcgtatgc
    24721 gacgccgacg aagatgccgc cgccgatcag cgcgatcagc atgatggcgc gcgggatggt
    24781 gcggcgcggg ttgacggtct cctcggtgag cgtggtgacc gcgtcgaagc cgaggaagga
    24841 gtaggccgcg atggcggcgc cggccgagat gcccgcgaag gtggtggcgc tgttggcgaa
    24901 cggtgtgccg ctgaccaccg ccccggctcc gccgaggtgg aagacatggc gcagcgagag
    24961 cagtacgaag atcgcgatga ccaggatctg gaagaccatg agcaggtcgt tgacccgctc
    25021 ggcggtcttg atccccagca ggttgagcac ggtggtgagg accacgaagg ccaggatcca
    25081 ggtccagaag gggaccccgg ggaactgggc ctggaggtag gccccgccga tcagccagat
    25141 gaccatcggc aggaagaagt agtccagcag ggtggcccag ccgaccagga agcccacccg
    25201 ggagtcgatg gaccgccgga cgtaggtgta cgcggagccg gccaccgggt ggaaggcggc
    25261 catccgtccg tagctgtggg cggtgaagat catcgccgcc agcgccagca gataggcggt
    25321 gggggtcgcg ccatgggtga tgtcggccac cacgcc
//
