GCF_003217475.1 - 20 region(s)

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Location: 188,583 - 209,446 nt. (total: 20,864 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DFR67_RS00965: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

DFR67_RS00985: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000678.5	0.45	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002216.3	0.45	terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0000189.4	0.37	PKS	3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole	Xenorhabdus bovienii SS-2004
BGC0000709.5	0.35	saccharide	neomycin	Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0001610.5	0.34	other (other)	gougerotin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0000120.5	0.32	PKS	patulin	Penicillium expansum
BGC0001687.3	0.31	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0002387.2	0.31	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0001228.5	0.31	NRPS	retimycin A	Salinispora arenicola CNT005
BGC0001594.3	0.31	other (other)	fischerindole L	Fischerella muscicola UTEX 1829

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000678.5	0.45	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002216.3	0.45	terpene	HEx-tc1 terpene	Trichoderma virens Gv29-8
BGC0000189.4	0.37	PKS	3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole	Xenorhabdus bovienii SS-2004
BGC0000709.5	0.35	saccharide	neomycin	Streptomyces fradiae ATCC 10745 = DSM 40063
BGC0001610.5	0.34	other (other)	gougerotin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0000120.5	0.32	PKS	patulin	Penicillium expansum
BGC0001687.3	0.31	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12
BGC0002387.2	0.31	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0001228.5	0.31	NRPS	retimycin A	Salinispora arenicola CNT005
BGC0001594.3	0.31	other (other)	fischerindole L	Fischerella muscicola UTEX 1829

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Chain length	Initial cyclisations	Functional groups
sesquiterpene	C15	C1-C6	none
diterpene	C20	C1-C6	none
diterpene	C20	C1-C7 + C6-C10	none
sesterterpene	C25	C1-C7 + C6-C10	none

Genes with terpene domains:

DFR67_RS00950: TS_UbiA

Domain 1 (2 - 283): UbiA type terpene synthase

Reactions:: FPP → sesquiterpene_C1-C6; GGPP → diterpene_C1-C6; GGPP → diterpene_C1-C7/C6-C10; GFPP → sesterterpene_C1-C7/C6-C10

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

Additional weak hits (4):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.97 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.18 out of 21.55

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_QJSP01000001.1 - Region 2 - terpene

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Location: 376,516 - 397,649 nt. (total: 21,134 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

DFR67_RS01895: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Ligases: ligase

DFR67_RS01830: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000656.5	0.42	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002578.2	0.42	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000563.4	0.41	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.41	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000595.3	0.37	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000656.5	0.42	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002578.2	0.42	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000563.4	0.41	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.41	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000595.3	0.37	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

DFR67_RS01840: Lycopene_cycl

Domain 1 (7 - 357): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.26 out of 18.57

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description

NZ_QJSP01000002.1 - Region 1 - NRPS

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Location: 336,937 - 394,831 nt. (total: 57,895 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DFR67_RS04380: nucleotide sugar dehydrogenase

smcogs: SMCOG1152: nucleotide sugar dehydrogenase

DFR67_RS04390: dihydropteridine reductase

smcogs: SMCOG1159: dihydropteridine reductase

Transferases: glycosyltransferase

DFR67_RS04370: sugar transferase

smcogs: SMCOG1146: sugar transferase

DFR67_RS04415: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

DFR67_RS04480: sugar transferase

smcogs: SMCOG1146: sugar transferase

DFR67_RS04520: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Lyases: cyclase dehydratase

DFR67_RS04425: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

DFR67_RS04430: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

DFR67_RS04470: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

DFR67_RS04475: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: ligase

DFR67_RS04440: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001166.5	0.67	NRPS	HC-toxin	Alternaria jesenskae
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001166.5	0.67	NRPS	HC-toxin	Alternaria jesenskae
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.24 out of 27.55

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.61 out of 20.97

Confidence: medium

Additional weak hits (11):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.96 out of 21.55

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.91 out of 27.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.16 out of 29.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.85 out of 30.25

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.13 out of 24.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.58 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.36 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.93 out of 29.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.35 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.98 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 336936 - 394831:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - Thr - Leu - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DFR67_RS04440: X - X - Thr - Leu - X

Search NORINE for peptide: strict or relaxed

AMP-binding (468..857): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LQQAFDASIFELVIMLAGESNLYGPAEATVMATG
Nearest Stachelhaus code(s):: D-Ph-Lac GAFVMAGVCK (59% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1497..1894): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LACHFDVSVFEASQVFAGESNMYGITETTVHLTQ
Nearest Stachelhaus code(s):: Ser DVWSVAMVHK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (2573..2972): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSAHFDFSVWEGNQLFGGEVNMYGITETTVHASV
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (3597..3990): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LAVYFDAHLIEPFSATGGEVNFYGPTEATIAATV
Nearest Stachelhaus code(s):: Leu DAILLGGIAK (65% 8Å match); Leu or Phe DAIMLGGIAK (59% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (5168..5545): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LPAAFDASILEWFAFVGGETNLYGPTETTVLGTA
Nearest Stachelhaus code(s):: Arg DALFFGLVDK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor
CcpA	Catabolite control protein A
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_QJSP01000003.1 - Region 1 - T3PKS,terpene

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Location: 107,778 - 161,795 nt. (total: 54,018 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

DFR67_RS05595: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

DFR67_RS05700: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

DFR67_RS05720: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: glycosyltransferase sulfhydrylase transketolase

DFR67_RS05535: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

DFR67_RS05600: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

DFR67_RS05640: transketolase

smcogs: SMCOG1204: transketolase

Ligases: synthase synthetase

DFR67_RS05605: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

DFR67_RS05695: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

DFR67_RS05710: pseudouridine synthase

smcogs: SMCOG1279: pseudouridine synthase

Translocases: permease

DFR67_RS05670: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

DFR67_RS05715: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.3	0.23	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0002362.3	0.23	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0000665.5	0.22	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000666.5	0.20	terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0000679.5	0.20	terpene	diazepinomicin	Micromonospora sp. M42
BGC0000637.3	0.19	terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.3	0.19	terpene	carotenoid	Dietzia sp. CQ4
BGC0001962.3	0.19	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001848.4	0.18	other (other)	diazaquinomycin H, diazaquinomycin J	Micromonospora sp. B006
BGC0002403.2	0.18	PKS	β-Diketones	Hordeum vulgare subsp. vulgare

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000650.3	0.56	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000644.3	0.53	terpene	carotenoid	Dietzia sp. CQ4
BGC0000637.3	0.53	terpene	carotenoid	Corynebacterium glutamicum
BGC0001962.3	0.51	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002403.2	0.49	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0001456.3	0.48	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.48	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.48	terpene	carotenoid	Streptomyces avermitilis
BGC0002309.2	0.47	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001757.3	0.47	other (other)	rhabduscin	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

DFR67_RS05695: PT_FPPS_like

Domain 1 (59 - 364): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

DFR67_RS05705: PT_phytoene_like

Domain 1 (28 - 300): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.45 out of 25.88

Confidence: medium

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 28.54 out of 32.93

Confidence: medium

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 30.10 out of 32.38

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.81 out of 18.57

Confidence: medium

Additional weak hits (11):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.27 out of 18.57

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.82 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.11 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.91 out of 21.55

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.18 out of 30.97

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.97 out of 21.55

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.93 out of 27.04

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.27 out of 26.85

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.45 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CsoR	Copper-responsive repressor
PsrA	Oleic acid responsive regulator
RicR	Copper-responsive regulator
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_QJSP01000004.1 - Region 1 - T1PKS

Download region SVG

Location: 35,109 - 80,268 nt. (total: 45,160 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DFR67_RS07545: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS07610: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: acylase transferase

DFR67_RS07595: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

DFR67_RS07600: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

DFR67_RS07625: putative esterase

smcogs: SMCOG1104: putative esterase

DFR67_RS07630: putative esterase

smcogs: SMCOG1104: putative esterase

Ligases: ligase

DFR67_RS07605: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

Additional weak hits (11):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.51 out of 30.22

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.47 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.14 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.87 out of 27.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.04 out of 32.93

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.10 out of 28.14

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.70 out of 39.62

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.35 out of 27.18

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.10 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 35108 - 80268:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DFR67_RS07600: pk

PKS_AT (693..995): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 58.3%; Malonyl-CoA: 54.2%

minowa: fatty_acid

Prediction, score:

fatty_acid: 178.3
Methylmalonyl-CoA: 82.4
Methoxymalonyl-CoA: 67.3
Malonyl-CoA: 61.8
Propionyl-CoA: 56.0
Isobutyryl-CoA: 55.0
trans-1,2-CPDA: 44.3
Ethylmalonyl-CoA: 42.9
2-Methylbutyryl-CoA: 38.1
Acetyl-CoA: 28.9
Benzoyl-CoA: 26.6
CHC-CoA: 26.2
inactive: 19.5
3-Methylbutyryl-CoA: 0.0

DFR67_RS07605: NH2

CAL_domain (56..516): NH2

minowa: NH2

Prediction, score:

NH2: 53.6
Acetyl-CoA: 27.1
AHBA: 9.4
shikimic_acid: 2.4
fatty_acid: 0.0

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein

NZ_QJSP01000005.1 - Region 1 - NRP-metallophore,NRPS,lanthipeptide-class-ii

BGC0002110.3 (QKV49893.1):

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Location: 35,406 - 105,450 nt. (total: 70,045 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

DFR67_RS09520: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

DFR67_RS09615: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

DFR67_RS09625: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

DFR67_RS09650: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: formyltransferase methyltransferase

DFR67_RS09485: methyltransferase

smcogs: SMCOG1089: methyltransferase

DFR67_RS09645: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Hydrolases: dehalogenase hydrolase

DFR67_RS09620: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

DFR67_RS09715: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Lyases: cyclase

DFR67_RS09505: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

DFR67_RS09515: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: ligase

DFR67_RS09640: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DFR67_RS09670: carboxylate-amine ligase

smcogs: SMCOG1165: carboxylate-amine ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.83	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.81	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.80	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.79	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.77	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.76	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.75	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.74	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.73	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.71	NRPS	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.72	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for DFR67_RS09505

DFR67_RS09500

Leader:

MIDKSISLAEEIDEQHFDGVAYGA

Core:

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

Core with dehydrations:

CysDhbDhbNDhbFDhbLDhaDFLGNDGGWCysDhbLDhbKEDhaQNNCysQ

antiSMASH-DB 4.0 matches for DFR67_RS09500

100.0%

NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28205_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide

Lanthipeptides: BH683_RS28205_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

30

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

30

80.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

C+TNTF+LSDFLGN GGWCTLTKE Q NC

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNC

29

80.0%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLTKE Q NC

1

CTTNTFSLSDALGNHGGWCTLTKECQANC

29

with 102 more sequence matches

Only the first 10 are displayed here.

80.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLTKE Q NC

1

CTTNTFSLSDALGNSGGWCTLTKECQPNC

29

80.0%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLTKE Q NC

1

CTTNTFSLSDALGNHGGWCTLTKECQPNC

29

80.0%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLTKE Q NC

1

CTTNTFSLSDSLGNHGGWCTLTKECQPNC

29

80.0%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD+LGN GGWCTLTKE Q NC

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNC

29

80.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTFTLSD+LGN GGWCTLTKE Q +C

1

CTTNTFTLSDYLGNKGGWCTLTKECQRSC

29

76.7%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLT E Q NC

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNC

29

76.7%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD +GN GGWCTLTKE Q NC

1

CTTNTFSLSDAVGNHGGWCTLTKECQPNC

29

76.7%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

30

CTTNTFTLS+ LGN GGWCTLT E Q NC+

1

CTTNTFTLSNVLGNQGGWCTLTVECQPNCK

30

76.7%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTFTLS++LGN+GGWCTLTKE Q +C

1

CTTNTFTLSNYLGNNGGWCTLTKECQRSC

29

73.3%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD L N GGWCTLT E Q NC

1

CTTNTFSLSDALTNTGGWCTLTVECQPNC

29

MIBiG 4.0 matches for DFR67_RS09500

76.7%

Lanthipeptide: birimositide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LS+ LGN+GGWCTLTKE Q NC

1

CTTNTFSLSNALGNNGGWCTLTKECQPNC

29

36.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FTLSDFLGNDGGWCTLTKESQNNC

29

+ +S LGN G +CTLT E +C

4

YNISCRLGNKGAYCTLTVECMPSC

27

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTKESQNNC

29

CTL+KE Q NC

28

CTLSKECQPNC

38

DFR67_RS30760

Leader:

MAVDKAGRYDESELIALNETEAAGG

Core:

THPTTISLASALSVALCPTFKCTGVDGGCG

Core with dehydrations:

DhbHPDhbDhbIDhaLADhaALDhaVALCysPDhbFKCysDhbGVDGGCysG

antiSMASH-DB 4.0 matches for DFR67_RS30760

100.0%

NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28810_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide

Lanthipeptides: BH683_RS28810_lanthipeptide

1

THPTTISLASALSVALCPTFKCTGVDGGCG

30

THPTTISLASALSVALCPTFKCTGVDGGCG

1

THPTTISLASALSVALCPTFKCTGVDGGCG

30

40.6%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

T P T ++ A+SV LCPT KCT

7

TTPATPTIVVAISVGLCPTTKCT

29

40.0%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

4

TTISLASALSVALCPTFKCTGVDGGCG

30

T+I A S A+CPT C+ GG G

3

TSIPCAVMASTAICPTLVCSNKCGGRG

29

with 64 more sequence matches

Only the first 10 are displayed here.

38.2%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

THPTTISLASALSVALCPTFKCTGVDGGC

29

THPTTI +S+A+CPT C C

7

THPTTI---IPVSLAVCPTTTCRSFSSPC

32

37.5%

NZ_CP036019.1and 7 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide

Lanthipeptides: EXW52_RS27190_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

T P T ++ A+SV LCPT +CT

7

TTPATPTIVVAISVGLCPTNRCT

29

37.5%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

T P T ++ +SV LCPT KCT

7

TTPATPTIVVGISVGLCPTTKCT

29

36.7%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

4

TTISLASALSVALCPTFKCT

23

TT+ A A S+ALCPT C+

2

TTVPCAVAASIALCPTLACS

21

36.7%

NZ_CP040417.1and 2 others:

NZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptideNZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptide

Lanthipeptides: FE328_RS05340_lanthipeptide

4

TTISLASALSVALCPTFKCTGVDGGCG

30

T+I +S A+CPT C+ GG G

3

TSIPCTVMVSAAVCPTLVCSNKCGGRG

29

36.7%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

THP+T+ +S+ALCPT +C+

1

THPSTLI---PISIALCPTTRCS

20

33.3%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27195_lanthipeptide

Lanthipeptides: EXW52_RS27195_lanthipeptide

1

THPTTISLASALSVALCPT

19

T P T ++ A+SV LCPT

7

TTPATPTIVVAISVGLCPT

25

33.3%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

12

LSVALCPTFKCTG

24

LS+ALCPT KCT

9

LSIALCPTAKCTS

21

33.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

T P I +S+A CPT KCT

4

TVPCGIGSTITISIAYCPTSKCT

26

31.6%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

THPTTISLASALSVALCPTFKCTGVDGGCG

30

+HPTT ++ +S CPT KC V C

9

SHPTT-TVTIPISAWGCPTTKCASVVEPCN

37

MIBiG 4.0 matches for DFR67_RS30760

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

8

LASALSVALCPTFKCT

23

+A +S A CPT KCT

19

VAVGVSAAFCPTTKCT

34

20.6%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

13

SVALCPTFKCTGVDGGCG

30

S++LC TG GC

3

SISLCTPGCKTGALMGCN

20

20.0%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

10

SALSVALC

17

S+LSV LC

13

SSLSVVLC

20

with 1 more sequence matches

20.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

16

LCPTFKCT

23

CPT KCT

16

FCPTTKCT

23

Lanthipeptide(s) for DFR67_RS09515

DFR67_RS09500

Leader:

MIDKSISLAEEIDEQHFDGVAYGA

Core:

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

Core with dehydrations:

CysDhbDhbNDhbFDhbLDhaDFLGNDGGWCysDhbLDhbKEDhaQNNCysQ

antiSMASH-DB 4.0 matches for DFR67_RS09500

100.0%

NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28205_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide

Lanthipeptides: BH683_RS28205_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

30

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

30

80.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

C+TNTF+LSDFLGN GGWCTLTKE Q NC

1

CSTNTFSLSDFLGNQGGWCTLTKECQPNC

29

80.0%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLTKE Q NC

1

CTTNTFSLSDALGNHGGWCTLTKECQANC

29

with 102 more sequence matches

Only the first 10 are displayed here.

80.0%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLTKE Q NC

1

CTTNTFSLSDALGNSGGWCTLTKECQPNC

29

80.0%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLTKE Q NC

1

CTTNTFSLSDALGNHGGWCTLTKECQPNC

29

80.0%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLTKE Q NC

1

CTTNTFSLSDSLGNHGGWCTLTKECQPNC

29

80.0%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD+LGN GGWCTLTKE Q NC

1

CTTNTFSLSDWLGNQGGWCTLTKECQPNC

29

80.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTFTLSD+LGN GGWCTLTKE Q +C

1

CTTNTFTLSDYLGNKGGWCTLTKECQRSC

29

76.7%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD LGN GGWCTLT E Q NC

1

CTTNTFSLSDVLGNTGGWCTLTVECQPNC

29

76.7%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD +GN GGWCTLTKE Q NC

1

CTTNTFSLSDAVGNHGGWCTLTKECQPNC

29

76.7%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNCQ

30

CTTNTFTLS+ LGN GGWCTLT E Q NC+

1

CTTNTFTLSNVLGNQGGWCTLTVECQPNCK

30

76.7%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTFTLS++LGN+GGWCTLTKE Q +C

1

CTTNTFTLSNYLGNNGGWCTLTKECQRSC

29

73.3%

NZ_JAASAG010000001.1and 1 other:

NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide

Lanthipeptides: HCC61_RS30395_lanthipeptide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LSD L N GGWCTLT E Q NC

1

CTTNTFSLSDALTNTGGWCTLTVECQPNC

29

MIBiG 4.0 matches for DFR67_RS09500

76.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CTTNTFTLSDFLGNDGGWCTLTKESQNNC

29

CTTNTF+LS+ LGN+GGWCTLTKE Q NC

1

CTTNTFSLSNALGNNGGWCTLTKECQPNC

29

36.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FTLSDFLGNDGGWCTLTKESQNNC

29

+ +S LGN G +CTLT E +C

4

YNISCRLGNKGAYCTLTVECMPSC

27

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTLTKESQNNC

29

CTL+KE Q NC

28

CTLSKECQPNC

38

DFR67_RS30760

Leader:

MAVDKAGRYDESELIALNETEAAGG

Core:

THPTTISLASALSVALCPTFKCTGVDGGCG

Core with dehydrations:

DhbHPDhbDhbIDhaLADhaALDhaVALCysPDhbFKCysDhbGVDGGCysG

antiSMASH-DB 4.0 matches for DFR67_RS30760

100.0%

NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28810_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide

Lanthipeptides: BH683_RS28810_lanthipeptide

1

THPTTISLASALSVALCPTFKCTGVDGGCG

30

THPTTISLASALSVALCPTFKCTGVDGGCG

1

THPTTISLASALSVALCPTFKCTGVDGGCG

30

40.6%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

T P T ++ A+SV LCPT KCT

7

TTPATPTIVVAISVGLCPTTKCT

29

40.0%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

4

TTISLASALSVALCPTFKCTGVDGGCG

30

T+I A S A+CPT C+ GG G

3

TSIPCAVMASTAICPTLVCSNKCGGRG

29

with 64 more sequence matches

Only the first 10 are displayed here.

38.2%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

THPTTISLASALSVALCPTFKCTGVDGGC

29

THPTTI +S+A+CPT C C

7

THPTTI---IPVSLAVCPTTTCRSFSSPC

32

37.5%

NZ_CP036019.1and 7 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide

Lanthipeptides: EXW52_RS27190_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

T P T ++ A+SV LCPT +CT

7

TTPATPTIVVAISVGLCPTNRCT

29

37.5%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

T P T ++ +SV LCPT KCT

7

TTPATPTIVVGISVGLCPTTKCT

29

36.7%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

4

TTISLASALSVALCPTFKCT

23

TT+ A A S+ALCPT C+

2

TTVPCAVAASIALCPTLACS

21

36.7%

NZ_CP040417.1and 2 others:

NZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptideNZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptide

Lanthipeptides: FE328_RS05340_lanthipeptide

4

TTISLASALSVALCPTFKCTGVDGGCG

30

T+I +S A+CPT C+ GG G

3

TSIPCTVMVSAAVCPTLVCSNKCGGRG

29

36.7%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

THP+T+ +S+ALCPT +C+

1

THPSTLI---PISIALCPTTRCS

20

33.3%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27195_lanthipeptide

Lanthipeptides: EXW52_RS27195_lanthipeptide

1

THPTTISLASALSVALCPT

19

T P T ++ A+SV LCPT

7

TTPATPTIVVAISVGLCPT

25

33.3%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

12

LSVALCPTFKCTG

24

LS+ALCPT KCT

9

LSIALCPTAKCTS

21

33.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

1

THPTTISLASALSVALCPTFKCT

23

T P I +S+A CPT KCT

4

TVPCGIGSTITISIAYCPTSKCT

26

31.6%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

THPTTISLASALSVALCPTFKCTGVDGGCG

30

+HPTT ++ +S CPT KC V C

9

SHPTT-TVTIPISAWGCPTTKCASVVEPCN

37

MIBiG 4.0 matches for DFR67_RS30760

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

8

LASALSVALCPTFKCT

23

+A +S A CPT KCT

19

VAVGVSAAFCPTTKCT

34

20.6%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

13

SVALCPTFKCTGVDGGCG

30

S++LC TG GC

3

SISLCTPGCKTGALMGCN

20

20.0%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

10

SALSVALC

17

S+LSV LC

13

SSLSVVLC

20

with 1 more sequence matches

20.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

16

LCPTFKCT

23

CPT KCT

16

FCPTTKCT

23

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.67 out of 26.33

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.21 out of 28.19

Confidence: medium

Additional weak hits (13):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.72 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.21 out of 32.74

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.20 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.74 out of 30.22

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.10 out of 26.12

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.61 out of 26.85

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.44 out of 30.22

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.22 out of 27.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.75 out of 32.93

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.33 out of 24.78

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.13 out of 25.88

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.85 out of 26.12

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.56 out of 27.18

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

Lanthipeptides

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Core peptide predictions

DFR67_RS09500 - Class II

Cleavage pHMM score: -3.70

RODEO score: 0

Monoisotopic mass: 3153.4 Da

Molecular weight: 3155.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3173.4 Da N = 1; 3191.4 Da N = 2; 3209.4 Da N = 3; 3227.5 Da N = 4; 3245.5 Da N = 5

DFR67_RS30760 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 2762.4 Da

Molecular weight: 2764.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2782.2 Da N = 1; 2800.2 Da N = 2; 2818.2 Da N = 3; 2836.2 Da N = 4; 2854.3 Da N = 5

DFR67_RS09500 - Class II

Cleavage pHMM score: -3.70

RODEO score: 0

Monoisotopic mass: 3153.4 Da

Molecular weight: 3155.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3173.4 Da N = 1; 3191.4 Da N = 2; 3209.4 Da N = 3; 3227.5 Da N = 4; 3245.5 Da N = 5

DFR67_RS30760 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 2762.4 Da

Molecular weight: 2764.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2782.2 Da N = 1; 2800.2 Da N = 2; 2818.2 Da N = 3; 2836.2 Da N = 4; 2854.3 Da N = 5

Predicted core structure(s)

For candidate cluster 1, location 35405 - 105450:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 50421 - 105450:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DFR67_RS09640: X - X - X

AMP-binding (482..871): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FQASFDASIFELVCVVGGDFNSYGPTETTVVVTM
Nearest Stachelhaus code(s):: Leu DALLVGAVVK (62% 8Å match); Trp DAWSVGSVCK (59% 8Å match); Lys DAEDIGSVVK (56% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1533..1913): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LERTFDMAIGEALIGVGGERNGYGPTEATDIATV
Nearest Stachelhaus code(s):: Leu or Ile DMGWMGGVIK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (2568..2952): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LERTFDMAIGESLIGVGGERNGYGPTEATDIATV
Nearest Stachelhaus code(s):: Leu or Ile DMGWMGGVIK (44% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_QJSP01000005.1 - Region 2 - NRP-metallophore,NRPS

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Location: 326,346 - 369,189 nt. (total: 42,844 nt) Show pHMM detection rules used

Region on contig edge.

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

DFR67_RS10805: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS10825: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS10870: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: acetyltransferase

DFR67_RS10810: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Ligases: ligase

DFR67_RS10865: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DFR67_RS10885: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DFR67_RS10900: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.65	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.62	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.61	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.67	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001833.4	0.65	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (9):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.90 out of 30.22

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.84 out of 21.84

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.61 out of 30.97

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.73 out of 36.53

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.03 out of 25.88

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.70 out of 36.53

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.54 out of 29.38

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.99 out of 27.55

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.49 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 326345 - 369189:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Orn - Ser - D-OH-Orn)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DFR67_RS10865: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (38..444): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SASLFAMRSPGGSVRVGGAQQSFGMAEGLTTFTG
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

DFR67_RS10885: Orn - Ser - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (1350..1764): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: MNHTFDASWEQWDVSLGGEFNLYGPTEYTINALG
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (79% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (2438..2855): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFCSGEHNLYGPTEAAIDVTF
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3532..3949): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: MNHVFDMSWEEWNVLLGGEYNLYGPTEYTINALG
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

DFR67_RS10900: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (453..799): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWGTFDVSVPESNFMLAGELNIYGPTEAGEVMYY
Nearest Stachelhaus code(s):: Ala DVYNMAIVYK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein

NZ_QJSP01000006.1 - Region 1 - arylpolyene

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Location: 106,041 - 147,204 nt. (total: 41,164 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

DFR67_RS11520: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

DFR67_RS11535: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

DFR67_RS11600: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

DFR67_RS11625: nucleotide sugar dehydrogenase

smcogs: SMCOG1152: nucleotide sugar dehydrogenase

DFR67_RS11635: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: kinase

DFR67_RS11640: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: hydrolase

DFR67_RS11655: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: dehydratase

DFR67_RS11665: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

DFR67_RS11565: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000820.5	0.50	other (other)	physostigmine	Streptomyces griseofuscus
BGC0000779.3	0.48	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0001774.5	0.45	other (other)	spicamycin	Streptomyces fimbriatus
BGC0000647.3	0.45	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000707.5	0.43	saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000645.3	0.42	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000868.5	0.42	other (other)	teichuronic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0000813.3	0.42	other (other)	K-252a	Nonomuraea longicatena
BGC0000898.5	0.42	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000820.5	0.50	other (other)	physostigmine	Streptomyces griseofuscus
BGC0000779.3	0.48	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0001774.5	0.45	other (other)	spicamycin	Streptomyces fimbriatus
BGC0000647.3	0.45	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000707.5	0.43	saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000645.3	0.42	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000868.5	0.42	other (other)	teichuronic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0000813.3	0.42	other (other)	K-252a	Nonomuraea longicatena
BGC0000898.5	0.42	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.07 out of 23.79

Confidence: medium

Additional weak hits (5):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.10 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.97 out of 29.38

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.39 out of 35.63

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism

NZ_QJSP01000007.1 - Region 1 - NAPAA,NRP-metallophore,NRPS

Download region SVG

Location: 20,754 - 116,422 nt. (total: 95,669 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NAPAA: (AMP-binding and TIGR02353)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

DFR67_RS12780: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

DFR67_RS12845: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

DFR67_RS12915: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

DFR67_RS12935: dioxygenase, TauD/TfdA

smcogs: SMCOG1121: dioxygenase, TauD/TfdA

DFR67_RS12940: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

DFR67_RS12985: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase phosphorylase transferase

DFR67_RS12760: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

DFR67_RS12850: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

DFR67_RS13025: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: deformylase esterase hydrolase

DFR67_RS12670: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

DFR67_RS12770: thioesterase

smcogs: SMCOG1004: thioesterase

DFR67_RS12945: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: dehydratase

DFR67_RS13030: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

DFR67_RS13035: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: isomerase

DFR67_RS12805: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

DFR67_RS12650: carboxylate-amine ligase

smcogs: SMCOG1165: carboxylate-amine ligase

DFR67_RS12740: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DFR67_RS12750: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DFR67_RS12765: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

DFR67_RS12785: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

DFR67_RS12810: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DFR67_RS12950: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DFR67_RS12975: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Translocases: permease

DFR67_RS12700: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.94	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.93	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.93	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.93	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.91	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.88	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.83	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.83	NRPS	epichloenin A	Epichloe festucae
BGC0002276.2	0.79	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002071.2	0.72	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.77	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001027.5	0.67	NRPS, PKS	nocobactin NA, nocobactin NA 10152B	Nocardia farcinica IFM 10152
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.66	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.29 out of 26.85

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.23 out of 23.79

Confidence: medium

Additional weak hits (13):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.70 out of 26.33

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.33 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.60 out of 30.25

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.40 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.87 out of 36.53

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.79 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.04 out of 39.62

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.43 out of 36.53

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.08 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.89 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.03 out of 35.63

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.62 out of 23.43

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 20753 - 116422:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Cys) + (Me-ohmal) + (Leu) + (D-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 20753 - 87078:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys) + (Me-ohmal) + (Leu) + (D-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 82621 - 116422:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DFR67_RS12740: X

AMP-binding (465..902): X

nrpys: N6-ohLys

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: lys (Lys)

Stachelhaus prediction details:

Stachelhaus sequence:: YDHWFDASWQPGDTALGGEYNCYGPTETTVEAVV
Nearest Stachelhaus code(s):: N6-ohLys DAQDAGCVEK (100% 8Å match); Lys DAQDAGCVEK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

DFR67_RS12750: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (494..884): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: HGFSFDASLFECHMPIGGERNNYGPTEAVVAATH
Nearest Stachelhaus code(s):: N6-ohLys DALHPGHVCK (76% 8Å match); Leu DALHSGAVAK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

DFR67_RS12760: mmal

PKS_AT (100..402): mmal

ATSignature: Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 66.7%; Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 103.3
Ethylmalonyl-CoA: 87.9
Methoxymalonyl-CoA: 83.1
Malonyl-CoA: 53.1
Propionyl-CoA: 51.5
trans-1,2-CPDA: 46.0
CHC-CoA: 38.5
2-Methylbutyryl-CoA: 37.6
Isobutyryl-CoA: 28.5
Benzoyl-CoA: 21.6
fatty_acid: 16.7
Acetyl-CoA: 13.7
3-Methylbutyryl-CoA: 13.6
inactive: 8.9

DFR67_RS12785: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (557..953): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDLSFDLSIYDGACFLGGDAGLGGTTETAIHATI
Nearest Stachelhaus code(s):: Ser DLYNLGLIHK (85% 8Å match); Lys DMYNFGLIHK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

DFR67_RS12810: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (40..445): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: NLSLFPLACPGGALQVGGAQQVFGMAEGLICYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVLCK (88% 8Å match); Sal TLPAQGVICK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

DFR67_RS12950: X

AMP-binding (7..382): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FAELFDASCEELSTIFGGEWNTYGPTEATVVACA
Nearest Stachelhaus code(s):: Lys DAEDIGTVVK (71% 8Å match); Gln or Tyr DAESVGTVVK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
RutR	Regulator of the pyrimidine and purine metabolism

NZ_QJSP01000009.1 - Region 1 - terpene

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Location: 1 - 18,973 nt. (total: 18,973 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DFR67_RS15615: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS15640: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

DFR67_RS15670: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Ligases: synthetase

DFR67_RS15645: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.59	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.58	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.55	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.55	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000649.3	0.55	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000648.3	0.50	terpene	carotenoid	Myxococcus xanthus
BGC0000645.3	0.47	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000650.3	0.47	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000677.5	0.46	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000644.3	0.44	terpene	carotenoid	Dietzia sp. CQ4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.59	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.58	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.55	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.55	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000649.3	0.55	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000648.3	0.50	terpene	carotenoid	Myxococcus xanthus
BGC0000645.3	0.47	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000650.3	0.47	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000677.5	0.46	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000644.3	0.44	terpene	carotenoid	Dietzia sp. CQ4

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

DFR67_RS15630: PT_phytoene_like

Domain 1 (7 - 295): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

DFR67_RS15645: PT_FPPS_like

Domain 1 (46 - 357): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 26.01 out of 29.65

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.50 out of 20.47

Confidence: medium

Additional weak hits (6):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.63 out of 25.88

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.38 out of 31.73

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.21 out of 20.97

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.39 out of 24.78

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.01 out of 39.62

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.32 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
LexA variant 1	Repressor of DNA damage response
VqsM	Regulator of quorum-sensing signalling systems

NZ_QJSP01000009.1 - Region 2 - azole-containing-RiPP

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Location: 128,721 - 151,998 nt. (total: 23,278 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DFR67_RS16240: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

DFR67_RS16245: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Lyases: hydratase

DFR67_RS16285: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase

DFR67_RS16255: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.57	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002128.3	0.57	other (other)	5-dimethylallylindole-3-acetonitrile	Streptomyces coelicolor A3(2)
BGC0001870.3	0.46	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002476.2	0.46	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0000947.5	0.45	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002073.3	0.45	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002494.3	0.44	NRPS	vibriobactin	Vibrio cholerae
BGC0000410.5	0.44	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0002682.2	0.44	other (other)	aerobactin	Vibrio mimicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.57	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002128.3	0.57	other (other)	5-dimethylallylindole-3-acetonitrile	Streptomyces coelicolor A3(2)
BGC0001870.3	0.46	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002476.2	0.46	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0000947.5	0.45	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002073.3	0.45	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002494.3	0.44	NRPS	vibriobactin	Vibrio cholerae
BGC0000410.5	0.44	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0002682.2	0.44	other (other)	aerobactin	Vibrio mimicus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.00 out of 29.38

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.09 out of 26.33

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.69 out of 29.38

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.10 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 26.44 out of 28.19

Confidence: strong

Additional weak hits (18):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.50 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.13 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.04 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.35 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.87 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.44 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.33 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.48 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.08 out of 29.38

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.00 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.11 out of 29.38

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.64 out of 27.18

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.52 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.21 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.00 out of 28.19

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.36 out of 27.18

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

Core peptide predictions

No core peptides found.

NZ_QJSP01000010.1 - Region 1 - RiPP-like

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Location: 199,503 - 210,309 nt. (total: 10,807 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

DFR67_RS17955: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Lyases: hydratase

DFR67_RS17960: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002196.2	0.28	PKS	clavatol	Penicillium crustosum
BGC0001882.3	0.27	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0002542.2	0.25	NRPS, PKS	apratoxin A	Moorena bouillonii bAprat14
BGC0000243.4	0.24	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001941.3	0.24	PKS	Fulvuthiacene A, Fulvuthiacene B	Myxococcus fulvus
BGC0001281.3	0.23	PKS	ustilagic acid	Ustilago maydis 521
BGC0001945.3	0.23	NRPS	chloromyxamide	Myxococcus sp.
BGC0001095.5	0.23	NRPS	fengycin	Bacillus velezensis FZB42
BGC0000173.5	0.21	PKS	isobongkrekic acid, bongkrekic acid	Burkholderia gladioli
BGC0001032.3	0.20	NRPS, PKS	oocydin A	Serratia plymuthica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002196.2	0.28	PKS	clavatol	Penicillium crustosum
BGC0001882.3	0.27	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0002542.2	0.25	NRPS, PKS	apratoxin A	Moorena bouillonii bAprat14
BGC0000243.4	0.24	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0001941.3	0.24	PKS	Fulvuthiacene A, Fulvuthiacene B	Myxococcus fulvus
BGC0001281.3	0.23	PKS	ustilagic acid	Ustilago maydis 521
BGC0001945.3	0.23	NRPS	chloromyxamide	Myxococcus sp.
BGC0001095.5	0.23	NRPS	fengycin	Bacillus velezensis FZB42
BGC0000173.5	0.21	PKS	isobongkrekic acid, bongkrekic acid	Burkholderia gladioli
BGC0001032.3	0.20	NRPS, PKS	oocydin A	Serratia plymuthica

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.74 out of 30.22

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_QJSP01000011.1 - Region 1 - betalactone

Download region SVG

Location: 88,651 - 117,869 nt. (total: 29,219 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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MIBiG comparison

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DFR67_RS18780: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS18790: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

DFR67_RS18800: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

DFR67_RS18880: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

DFR67_RS18885: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

DFR67_RS18890: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Ligases: ligase synthase

DFR67_RS18825: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

DFR67_RS18860: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000706.3	0.44	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001928.2	0.43	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000649.3	0.42	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002518.3	0.42	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0000671.3	0.41	terpene	momilactone B	Oryza sativa Japonica Group
BGC0000204.5	0.41	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001440.5	0.41	other (other)	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0000686.3	0.40	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001895.4	0.39	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000706.3	0.44	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0001928.2	0.43	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000649.3	0.42	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002518.3	0.42	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0000671.3	0.41	terpene	momilactone B	Oryza sativa Japonica Group
BGC0000204.5	0.41	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001440.5	0.41	other (other)	cystargolide A, cystargolide B	Kitasatospora cystarginea
BGC0000686.3	0.40	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001895.4	0.39	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.76 out of 21.84

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.36 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

Additional weak hits (9):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.32 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.30 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.67 out of 29.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.93 out of 28.14

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.49 out of 20.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.26 out of 31.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.13 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.90 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
MexT	Global virulence regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_QJSP01000013.1 - Region 1 - NRPS

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Location: 1 - 39,771 nt. (total: 39,771 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

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KnownClusterBlast

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase electron transfer oxidoreductase

DFR67_RS20725: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS20840: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

DFR67_RS20845: flavodoxin

smcogs: SMCOG1134: flavodoxin

Transferases: acyltransferase

DFR67_RS20710: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: esterase peptidase

DFR67_RS20720: putative esterase

smcogs: SMCOG1104: putative esterase

DFR67_RS20825: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (5):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.06 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.74 out of 30.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.13 out of 26.33

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 20.07 out of 22.40

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 36.53

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 39771:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - Leu - Leu - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DFR67_RS20710: Ser - Leu - Leu - X

Search NORINE for peptide: strict or relaxed

AMP-binding (502..907): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFTSGEHNLYGPTEAAVDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1578..1971): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FEQAFDASVLEMFVIIGGEFNAYGPTEATVAATI
Nearest Stachelhaus code(s):: Leu DALFVGAVAK (71% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (2641..3048): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LEQAFDASILELFIAVGGELNAYGPTETTVVSLM
Nearest Stachelhaus code(s):: Leu DALFAGAVMK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (3726..4122): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VELAFDASVLEMFIAVGGEYNVYGPTETTIITTS
Nearest Stachelhaus code(s):: Ile DAWFLGNIIK (62% 8Å match); n-oxoDec DGLTCGVIIK (50% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description

NZ_QJSP01000014.1 - Region 1 - ectoine

Download region SVG

Location: 112,951 - 123,349 nt. (total: 10,399 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

DFR67_RS22150: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000856.3	0.72	other (other)	ectoine	Methylophaga thalassica
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0002052.3	0.69	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.69	other (other)	ectoine	Streptomyces anulatus
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.60	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.55	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000856.3	0.72	other (other)	ectoine	Methylophaga thalassica
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0002052.3	0.69	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.69	other (other)	ectoine	Streptomyces anulatus
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.60	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.55	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.18 out of 20.47

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

Additional weak hits (5):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.16 out of 29.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.25 out of 30.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.72 out of 29.25

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.30 out of 32.93

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.89 out of 27.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
VqsM	Regulator of quorum-sensing signalling systems

NZ_QJSP01000015.1 - Region 1 - RiPP-like

Download region SVG

Location: 82,224 - 93,126 nt. (total: 10,903 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

DFR67_RS22845: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000254.5	0.26	PKS	oxytetracycline	Streptomyces rimosus
BGC0000209.5	0.22	PKS	chlortetracycline	Kitasatospora aureofaciens
BGC0001156.5	0.22	terpene	platencin	Streptomyces platensis
BGC0000216.5	0.20	PKS	dactylocycline A	Dactylosporangium sp. SC14051
BGC0002440.3	0.19	NRPS	longicatenamide B, longicatenamide C, longicatenamide A, longicatenamide D	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000254.5	0.26	PKS	oxytetracycline	Streptomyces rimosus
BGC0000209.5	0.22	PKS	chlortetracycline	Kitasatospora aureofaciens
BGC0001156.5	0.22	terpene	platencin	Streptomyces platensis
BGC0000216.5	0.20	PKS	dactylocycline A	Dactylosporangium sp. SC14051
BGC0002440.3	0.19	NRPS	longicatenamide B, longicatenamide C, longicatenamide A, longicatenamide D	Streptomyces sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.52 out of 29.38

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.77 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_QJSP01000016.1 - Region 1 - arylpolyene

Download region SVG

Location: 36,406 - 77,590 nt. (total: 41,185 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

DFR67_RS23400: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DFR67_RS23425: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

DFR67_RS23430: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

DFR67_RS23460: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: cyclase

DFR67_RS23355: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: synthase

DFR67_RS23360: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport

DFR67_RS23445: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001223.5	0.45	other (other)	hydroxysporine	uncultured bacterium
BGC0001224.5	0.45	other (other)	reductasporine	uncultured bacterium
BGC0000844.5	0.44	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0001605.3	0.44	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002347.3	0.43	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0001335.5	0.42	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0001483.4	0.42	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.56	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001223.5	0.45	other (other)	hydroxysporine	uncultured bacterium
BGC0001224.5	0.45	other (other)	reductasporine	uncultured bacterium
BGC0000844.5	0.44	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0001605.3	0.44	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002347.3	0.43	other (other)	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus caeruleus WH1-2216-6
BGC0001335.5	0.42	other (other)	borregomycin A, borregomycin B, borregomycin C, borregomycin D	uncultured bacterium
BGC0001483.4	0.42	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.86 out of 25.31

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.78 out of 29.72

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.50 out of 20.47

Confidence: medium

Additional weak hits (9):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.15 out of 27.78

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.38 out of 21.55

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 39.62

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.52 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.73 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.62 out of 30.25

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.54 out of 33.14

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.00 out of 32.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.55 out of 35.63

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CatR	H2O2-responsive repressor
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_QJSP01000018.1 - Region 1 - NRPS,redox-cofactor

Download region SVG

Location: 25,981 - 110,957 nt. (total: 84,977 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DFR67_RS24440: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

DFR67_RS24485: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

DFR67_RS24460: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: dehydratase

DFR67_RS24490: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

Ligases: ligase synthase

DFR67_RS24535: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

DFR67_RS24580: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

DFR67_RS24590: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Translocases: permease

DFR67_RS24410: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.42	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.40	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.39	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.37	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	0.37	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001128.4	0.35	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.35	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.35	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.34	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.33	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.72	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.71	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	0.69	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.68	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.52 out of 19.26

Confidence: medium

Additional weak hits (9):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.64 out of 18.57

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.32 out of 26.33

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.46 out of 24.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.54 out of 32.93

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.97 out of 24.78

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.80 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.40 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

RREFinder

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 25980 - 110957:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Ser - Val - X - X - Ser - X - Ser - D-X - D-Gln)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 37045 - 110957:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Ser - Val - X - X - Ser - X - Ser - D-X - D-Gln)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

DFR67_RS24580: Ser - Val - X - X - Ser - X - Ser - X - Gln

Search NORINE for peptide: strict or relaxed

AMP-binding (472..872): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: QWVTFDVSVWESSFLVAGEENLYGPTEFTVHATY
Nearest Stachelhaus code(s):: Ser DVYSLALVHK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (2016..2411): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LEQAFDASVLELFIVVGGEFNGYGPTETTCFADI
Nearest Stachelhaus code(s):: Val DAFFVGGTFK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (3202..3616): X

nrpys: Hse

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VWYSFDLTQKNTNLVAGGEVNSYGPTEASDVTAA
Nearest Stachelhaus code(s):: Hse DLKNVGSDVK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4294..4691): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FEQAFDASILELFVVAGGEYNGYGPTETTIMTNI
Nearest Stachelhaus code(s):: Val DALFVGLVAK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (5464..5865): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEHNLYGPTEAAVDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (6532..6923): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LDVAFDTSVGEAVMVVGGDRNAYGPTESTVIVTI
Nearest Stachelhaus code(s):: Ala DVWVVAAVIK (59% 8Å match); Trp DVGMVGAVAK (53% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (7591..8010): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: QWITFDLSVWEWTFLCIGEHNLYGPTEAAVSVTH
Nearest Stachelhaus code(s):: Thr DLWQLGLVHK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (8673..9075): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LEMAFDASIFEMFVAVAGDFNLYGPSEATIWSTS
Nearest Stachelhaus code(s):: Ph-Ser or Phe DAFTVAAIWK (65% 8Å match); Thr DMFCAGLIWK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (10235..10652): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: QWMTFDASVWEAQFFSGGEVNLYGPTEVTVDATS
Nearest Stachelhaus code(s):: Gln DAWQFGLVDK (68% 8Å match)
Stachelhaus code match:: 100% (strong)

RRE predictions

: RRE type: Mycofactocin_RRE; Location: 12 - 92; Score: 97.9

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
MexT	Global virulence regulator
RpoN	Regulator of nitrogen assimilation and virulence

NZ_QJSP01000020.1 - Region 1 - betalactone

Download region SVG

Location: 63,720 - 92,863 nt. (total: 29,144 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

DFR67_RS25695: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS25745: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

DFR67_RS25750: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

DFR67_RS25755: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS25770: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

DFR67_RS25775: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

DFR67_RS25780: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

DFR67_RS25785: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

DFR67_RS25790: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: carboxylase

DFR67_RS25760: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase

DFR67_RS25740: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

DFR67_RS25715: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

DFR67_RS25735: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001850.4	0.50	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000204.5	0.48	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002284.3	0.48	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000888.5	0.48	other (other)	bacilysin	Bacillus sp. CS93
BGC0000243.4	0.47	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000261.5	0.46	PKS	R1128	Streptomyces sp. R1128
BGC0002493.3	0.45	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000189.4	0.45	PKS	3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001850.4	0.50	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000204.5	0.48	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002284.3	0.48	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000888.5	0.48	other (other)	bacilysin	Bacillus sp. CS93
BGC0000243.4	0.47	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0000261.5	0.46	PKS	R1128	Streptomyces sp. R1128
BGC0002493.3	0.45	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0000189.4	0.45	PKS	3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (8):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.30 out of 20.97

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.26 out of 26.85

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.07 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.34 out of 36.54

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.97 out of 21.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.20 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.09 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_QJSP01000045.1 - Region 1 - NRPS