LOCUS       NZ_QJSP01000020        29144 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Williamsia limnetica strain DSM 45521 Ga0244495_120, whole genome
            shotgun sequence.
ACCESSION   NZ_QJSP01000020
VERSION     NZ_QJSP01000020.1
KEYWORDS    WGS; RefSeq.
SOURCE      Williamsia limnetica
  ORGANISM  Williamsia limnetica
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Williamsia.
REFERENCE   1  (bases 1 to 112436)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 112436)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JUN-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Expected Final Version            :: No
            Genome Coverage                   :: 169.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003217475.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 01:29:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,026
            CDSs (total)                      :: 5,970
            Genes (coding)                    :: 5,910
            CDSs (with protein)               :: 5,910
            Genes (RNA)                       :: 56
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3 (5S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 17 of 60
            Pseudo Genes (incomplete)         :: 43 of 60
            Pseudo Genes (internal stop)      :: 7 of 60
            Pseudo Genes (multiple problems)  :: 7 of 60
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:55:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 63719
            Orig. end                         :: 92863
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QJSP01000020.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..29144
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..29144
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..29144
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:19144]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..19144
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(<434..823)
                     /locus_tag="DFR67_RS25670"
                     /old_locus_tag="DFR67_12064"
                     /pseudo=""
     CDS             complement(<434..823)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005194128.1"
                     /locus_tag="DFR67_RS25670"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12064"
                     /product="DUF5318 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQRQVVDYALQRKSRLAEVYSGRTGVAEVCDASPYLLRAAKFHGR
                     PSATRCPICRKEQVTIVSWVFGEKLGQVSGSARTTEEILHLAVSQEEFSVHVVEVCRTC
                     SWNHLVQSYVSGLPPRPRVRRSRRVA"
     misc_feature    complement(930..941)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.3"
                     /tool="antismash"
     gene            1054..1695
                     /locus_tag="DFR67_RS25675"
                     /old_locus_tag="DFR67_12065"
     CDS             1054..1695
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1278: PadR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106975.1"
                     /locus_tag="DFR67_RS25675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12065"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_110472311.1"
                     /transl_table=11
                     /translation="MLELAVLGLLLESPMHGYELRKRLTGLLGAFRAFSYGSLYPSLRR
                     MQADGLIAEDAAPTGTLKRRARRVYALTPKGRERFAELVADTGPQNYTDDGFGVHLAFF
                     SRTPAEARMRILEGRRRQVEERREGLREAVGRSNRTVDRYTKQLHQLSLESSEREVRWL
                     NELIAAEGSERVEDPTAVSRNPGPLPTETVHAEPETTSVTPHKEGEPDHG"
     gene            1688..2788
                     /locus_tag="DFR67_RS25680"
                     /old_locus_tag="DFR67_12066"
     CDS             1688..2788
                     /EC_number="5.5.1.4"
                     /GO_function="GO:0004512 - inositol-3-phosphate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006021 - inositol biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106974.1"
                     /locus_tag="DFR67_RS25680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12066"
                     /product="inositol-3-phosphate synthase"
                     /protein_id="WP_084837771.1"
                     /transl_table=11
                     /translation="MGDNTNSVRVAIVGVGNCASSLVQGVQYYQDADENAVVPGLMHVK
                     FGQYHVRDVQFVAAFDVDAKKVGFDLSDAIFSSENNTIKIADVPPTGVTVQRGHTLDGL
                     GKYYRETITEADGEGADVVQTLKDAKVDVLVSYLPVGSEQADKFYAQCAIDANVAFVNA
                     LPVFIASDPVWAKKFADAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVTLDRTYQLNV
                     GGNMDFKNMLERERLESKKVSKTQAVTSNLTGSLSGKIDDKNVHIGPSDHVAWLDDRKW
                     AYVRLEGRAFGDVPLSLEYKLEVWDSPNSAGIIIDAVRAAKIAKDRGIGGPILPASAYL
                     MKSPPEQLADDVARTQLEAFIVGADA"
     gene            2911..3330
                     /locus_tag="DFR67_RS25685"
                     /old_locus_tag="DFR67_12067"
     CDS             2911..3330
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009680738.1"
                     /locus_tag="DFR67_RS25685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12067"
                     /product="SgcJ/EcaC family oxidoreductase"
                     /protein_id="WP_110472312.1"
                     /transl_table=11
                     /translation="MTQNSAATTPKTSDLNSIRAIIEDVQAGFNRNDADLMNVHLAEDA
                     IIVNARGVRLTGRPAIDEATREGLAAGFLRDATAYYQLTDIALLAPDVITAGKNAWSTQ
                     QDFEVGNPPEMNALYIFIRRSGRWLIWRRQNTLIA"
     gene            3437..3847
                     /locus_tag="DFR67_RS25690"
                     /old_locus_tag="DFR67_12068"
     CDS             3437..3847
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DFR67_RS25690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DFR67_12068"
                     /product="hypothetical protein"
                     /protein_id="WP_110472313.1"
                     /transl_table=11
                     /translation="MSGRFKSLVAGVAVAATIGVGGGLAVGTAPATAVTVRETQGIWVI
                     TLTHEETVAAAQVGAGNVINAVLGNDHWRVTLDSDSKYAGGSYYRPDKGRTWSNVTGQQ
                     VISEAAAHRNGYVVLGVFPDNPDMPLWVAQAW"
     gene            complement(3878..4624)
                     /locus_tag="DFR67_RS25695"
                     /old_locus_tag="DFR67_12069"
     CDS             complement(3878..4624)
                     /NRPS_PKS="Domain: PKS_KR (3-176). E-value: 8.3e-14. Score:
                     43.8. Matches aSDomain:
                     nrpspksdomains_DFR67_RS25695_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011560019.1"
                     /locus_tag="DFR67_RS25695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12069"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_110472314.1"
                     /sec_met_domain="adh_short (E-value: 7.9e-33, bitscore:
                     106.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.1e-33, bitscore:
                     108.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRVALVTGANRGLGAATALALAERKIKVVAASRGGAGEVVDDIV
                     QSGGEAIAVQMDVADLSSIEDARVAVLAGIRQEWDAGTINVLVNNAGVGLFAPLGDITA
                     EDFDATFAVNVRGPLFVTQAFLPHLSDGASIVNVSSSLSRHVSPATSVYAASKKALEAL
                     TRSLALELGPRGIRINSIAPGPTATDFNGGAMRDSEAMRAALSGQTALGRVGDPTDIAD
                     AISALVSHELRWATGERIEISGGVLL"
     aSDomain        complement(4097..4615)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS25695_PKS_KR.1"
                     /evalue="8.30E-14"
                     /label="DFR67_RS25695_PKS_KR.1"
                     /locus_tag="DFR67_RS25695"
                     /protein_end="176"
                     /protein_start="3"
                     /score="43.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGANRGLGAATALALAERKIKVVAASRGGAGEVVDDIVQSG
                     GEAIAVQMDVADLSSIEDARVAVLAGIRQEWDAGTINVLVNNAGVGLFAPLGDITAEDF
                     DATFAVNVRGPLFVTQAFLPHLSDGASIVNVSSSLSRHVSPATSVYAASKKALEALTRS
                     LALELGPRGI"
     CDS_motif       complement(4535..4609)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DFR67_RS25695_0001"
                     /evalue="1.30E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="DFR67_RS25695"
                     /protein_end="30"
                     /protein_start="5"
                     /score="14.7"
                     /tool="antismash"
                     /translation="LVTGANRGLGAATALALAERKIKVV"
     gene            4714..5292
                     /locus_tag="DFR67_RS25700"
                     /old_locus_tag="DFR67_12070"
     CDS             4714..5292
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011560018.1"
                     /locus_tag="DFR67_RS25700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12070"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_110472315.1"
                     /transl_table=11
                     /translation="MARDAEATRERILAAATDEFAAHGYAGGRVERIATKAQSNVRMIY
                     AYYGGKSGLFDAALAEALRRMAEDVPPRPDDLAGWAGDVFDHHQRFPEILRLSMWAQLE
                     RPEATAEPSEVYRNKALAVATAAAQPLSAVDVLVFIYAIAQAWQLSPQGLTGLDENPGS
                     GHDIAARRQSVVTAVERMLQAQSMNGSNE"
     gene            5343..6029
                     /locus_tag="DFR67_RS25705"
                     /old_locus_tag="DFR67_12071"
     CDS             5343..6029
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019512394.1"
                     /locus_tag="DFR67_RS25705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12071"
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_170135283.1"
                     /transl_table=11
                     /translation="MSRSVEQWAAQLQQLDRSEWLAFLDSNSGLPGPRANTSLATALAH
                     LADPGMVDQLLASDDEYQMLCGAVCLGAQVVDPEVRAKLRVLAVDERWRVREGVVIGIQ
                     EAADTDLPAVQSVVLDWAGDPEPLMARAAAAAICEPRLLRSPEAAAIAIDVCRHATAVL
                     VALPGTARRSAAARSLRQSLGYCWSVAVAADPTALAEFKALDNTDPDVEWIVRTNLKKK
                     RLARLL"
     gene            6195..6590
                     /locus_tag="DFR67_RS25710"
                     /old_locus_tag="DFR67_12072"
     CDS             6195..6590
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010844880.1"
                     /locus_tag="DFR67_RS25710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12072"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_110472354.1"
                     /transl_table=11
                     /translation="MRTEDNDSVVIGGGQIAGTAALTVVTVERDQLVIVTVQGSVDVLT
                     APQLSEAVDNALTGEPRGLIIDLSTTEFLASAGMSALVAAHEAIAPAGKLGVVADGPST
                     ARPIRLVGLDQTLTLYPTLEDAIGAMT"
     misc_feature    6637..6652
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.26"
                     /tool="antismash"
     misc_feature    6673..6687
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            6697..7734
                     /locus_tag="DFR67_RS25715"
                     /old_locus_tag="DFR67_12073"
     CDS             6697..7734
                     /EC_number="2.3.1.180"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018158683.1"
                     /locus_tag="DFR67_RS25715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12073"
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="WP_110472355.1"
                     /sec_met_domain="fabH (E-value: 6.8e-104, bitscore: 340.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAHIATAPPVAHAALLGLGVYRPRRVVPNSELVDQIDSTDEWIR
                     SRSGIESRRWAGADETIVSMSVAAAADALAASGLAADQIDAVVLATSSQMVLGPSAGAV
                     VATELGMHDTAAYDISAGCAGFCYALGNAAGLVRAGQARHVLVIGVERLSDLLDPTDRT
                     CAFIFADGAGAVVVGPSDSEGIGPTAWGSDGSQTDAIKQDKDFQEYFAEVAVAADGGAA
                     AERPYIRMKGQAVFRWAATFLDKAGRDVLDKSGLTVDDLDAFIPHQANSRITDALIRVL
                     HMPDSVAVARDIVETGNTSAASIPMAMEQVIRSGQARPGDTAMLLGFGAGLAYAGQVVR
                     LPAIV"
     gene            complement(7768..8496)
                     /locus_tag="DFR67_RS25720"
                     /old_locus_tag="DFR67_12074"
     CDS             complement(7768..8496)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004826 - phenylalanine-tRNA ligase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015448.4"
                     /locus_tag="DFR67_RS25720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12074"
                     /product="phenylalanine--tRNA ligase beta subunit-related
                     protein"
                     /protein_id="WP_211325163.1"
                     /transl_table=11
                     /translation="MSDFDVLSRAGVDEAVFDLRPDYRALLIAVDGLVPGPSDDTSEAL
                     LQEAEESARLALAQYPVEELPHMASWREAYRAFGAKPQRTRNSAEALLRRAESGLPRVN
                     RLTDVYNAISVIHQIPLGGEDLGRYRGAPRLIRADGSEQFDTTAAGEDVTEHPTAGEVV
                     WCDDIGVTCRRWNWRQGRRTQLNDATTTALFILDALDPMTDDELHLVGDELVRNLLPLG
                     PEVQTHRRLIVAGRGAANDE"
     gene            complement(8647..8865)
                     /locus_tag="DFR67_RS25725"
                     /old_locus_tag="DFR67_12075"
     CDS             complement(8647..8865)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020105898.1"
                     /locus_tag="DFR67_RS25725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12075"
                     /product="hypothetical protein"
                     /protein_id="WP_084837773.1"
                     /transl_table=11
                     /translation="MATEYYDTNADGIVDTALTDTDGDGIANYEEYDTDGDGMADEMHE
                     DANNDGYIDTVHVDTDGDGYYDTTVVG"
     gene            complement(9054..9800)
                     /locus_tag="DFR67_RS25730"
                     /old_locus_tag="DFR67_12076"
     CDS             complement(9054..9800)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106973.1"
                     /locus_tag="DFR67_RS25730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12076"
                     /product="FCD domain-containing protein"
                     /protein_id="WP_110472317.1"
                     /transl_table=11
                     /translation="MTAEDTVGPRIRGQKMSAKIANVIADQILTGGIVVGQRLPTEKEM
                     VAEHGVARTTVREALRLLESRDLVTIKSGIGGGPVAKRPELESLGNTMKLFLQIDSANI
                     SDVIDVRLMLEPIVARAAAENVTDEQIEVMQTALDRMREDPGDYANFQENNAVFQRCVY
                     EAAGNPALKIVMETLWLLVRDAEPNEHPMATRLAAVEMQQDVLDAMRARDAAATAKTMS
                     AFNEESAKYYRRRLADIISQPVHWQL"
     misc_feature    9944..9962
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.07"
                     /tool="antismash"
     misc_feature    complement(9948..9966)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.34"
                     /tool="antismash"
     gene            10001..11677
                     /locus_tag="DFR67_RS25735"
                     /old_locus_tag="DFR67_12077"
     CDS             10001..11677
                     /NRPS_PKS="Domain: AMP-binding (30-442). E-value: 1.4e-84.
                     Score: 276.0. Matches aSDomain:
                     nrpspksdomains_DFR67_RS25735_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106972.1"
                     /locus_tag="DFR67_RS25735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12077"
                     /product="AMP-binding protein"
                     /protein_id="WP_110472318.1"
                     /sec_met_domain="AMP-binding (E-value: 6.4e-94, bitscore:
                     307.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPTRPPKPELAQSFRDGGHWTDHPIGHFLTRAAQRYPMATAVAD
                     GDRRLTFADIDLQATRLAAALRARGVTADDVVSFQLPNCAEAVIVFQAVMKLGAVANPI
                     VPIYRSRELRFILGQSRAKVVFIAAELRGVDVDEMYRDLAAELPDLEWIISLGETSAGG
                     LAVTWADLMDSVSTQMVNQTRAIAPPAADDVCLLLYTSGTTADPKGALHSHNTLVYENR
                     SMIDWFSLNETDVIFNPSPVTHVTGINCALILPFVLGAPVVLQDAWDPAVALQRIVDEH
                     CSFMIFSTPFLRGLLDVSESTGTPTPSIRYIVCGGADIPDALTAAATDRLGTVVRMYGA
                     TEGPSVSTADRWDPLYLRISTDGRPMGPTELVVAGGNGGLAQVGEVGEIMWRGPDTFLG
                     YLESALNAAAFTADGFFRTGDLGRFDSSGAIHIVGRIKDIINRSGEKISAHDVENQLSE
                     HPAVVEVAVVAGPDPRTGERGCAFVVTRDHSDLTLGEVHSFLLEREIAVQKIPESVFVV
                     DSLPKTASGKVQKFALRDWTRDRDALPPQMATMTFAATHEK"
     aSDomain        10091..11326
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS25735_AMP-binding.1"
                     /evalue="1.40E-84"
                     /label="DFR67_RS25735_AMP-binding.1"
                     /locus_tag="DFR67_RS25735"
                     /protein_end="442"
                     /protein_start="30"
                     /score="276.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="TRAAQRYPMATAVADGDRRLTFADIDLQATRLAAALRARGVTADD
                     VVSFQLPNCAEAVIVFQAVMKLGAVANPIVPIYRSRELRFILGQSRAKVVFIAAELRGV
                     DVDEMYRDLAAELPDLEWIISLGETSAGGLAVTWADLMDSVSTQMVNQTRAIAPPAADD
                     VCLLLYTSGTTADPKGALHSHNTLVYENRSMIDWFSLNETDVIFNPSPVTHVTGINCAL
                     ILPFVLGAPVVLQDAWDPAVALQRIVDEHCSFMIFSTPFLRGLLDVSESTGTPTPSIRY
                     IVCGGADIPDALTAAATDRLGTVVRMYGATEGPSVSTADRWDPLYLRISTDGRPMGPTE
                     LVVAGGNGGLAQVGEVGEIMWRGPDTFLGYLESALNAAAFTADGFFRTGDLGRFDSSGA
                     IHIVGRIKDIINR"
     CDS_motif       10589..10642
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DFR67_RS25735_0001"
                     /evalue="1.50E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="DFR67_RS25735"
                     /protein_end="214"
                     /protein_start="196"
                     /score="17.7"
                     /tool="antismash"
                     /translation="LLYTSGTTADPKGALHSH"
     gene            11685..12467
                     /locus_tag="DFR67_RS25740"
                     /old_locus_tag="DFR67_12078"
     CDS             11685..12467
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (15-248). E-value: 1.6e-47. Score:
                     153.8. Matches aSDomain:
                     nrpspksdomains_DFR67_RS25740_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011598797.1"
                     /locus_tag="DFR67_RS25740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12078"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_110472319.1"
                     /transl_table=11
                     /translation="MTVQTPGIEHLVVTEPEPGIALVELARGKVNAIDTQMYDEIAEVF
                     DTLSDNQDIRAIVLTGRGRIFCAGNDLGSFRVMDAVSGDVEMRGVRRALFGLYDCALPV
                     IAAINGPALGSGLALASLSDIVVASDRATFGLPEMGVGVLGGGRFTARMLPQQAMRRMF
                     FTAEPVDAQTLRSWGAPLDVVPHDDLLEVAMSRARVIAAKSRYALTLAKQSLNGCEDVD
                     LKRGYELEQTFTVRLSEHPDSKKAVEARIAEMTKGKKS"
     aSDomain        11730..12428
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS25740_ECH.1"
                     /evalue="1.60E-47"
                     /label="DFR67_RS25740_ECH.1"
                     /locus_tag="DFR67_RS25740"
                     /protein_end="248"
                     /protein_start="15"
                     /score="153.8"
                     /tool="antismash"
                     /translation="PEPGIALVELARGKVNAIDTQMYDEIAEVFDTLSDNQDIRAIVLT
                     GRGRIFCAGNDLGSFRVMDAVSGDVEMRGVRRALFGLYDCALPVIAAINGPALGSGLAL
                     ASLSDIVVASDRATFGLPEMGVGVLGGGRFTARMLPQQAMRRMFFTAEPVDAQTLRSWG
                     APLDVVPHDDLLEVAMSRARVIAAKSRYALTLAKQSLNGCEDVDLKRGYELEQTFTVRL
                     SEHPDSKKAVE"
     gene            12464..13699
                     /locus_tag="DFR67_RS25745"
                     /old_locus_tag="DFR67_12079"
     CDS             12464..13699
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106970.1"
                     /locus_tag="DFR67_RS25745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12079"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_110472320.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.1e-10, bitscore:
                     34.9, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.2e-23, bitscore:
                     74.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 8.2e-22, bitscore:
                     70.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTPGSSGSAAAQVIDVDAFSEKCVAWLDEHLDRRETGSSVAAD
                     PNYAIFHNHTHDEERALIDAARAWQRKRVDAGFGAITWGPEWGGAGLTASHERVYVGLE
                     RQYNTPDRHETVLVTVELVAPTLHVLGTEDQKKQFVEPFLRTDLLCCQLFSEPGAGSDL
                     AGLSTKAVRSGDTWRINGQKVWSSGAQFSEWGLLIARTDTSVAKHRGMTAFMVPMDAPG
                     VDVRPIRQSSGGSTFNEVFLTDVELPDTMRVGAEGDGWKVALTTLGFERNSSAGIVSAG
                     GNSADLVRLAKSLGITDDPLVRQQLADAAIYERASALMVARYAEREQSGAVPGVEGSIG
                     KLVWTQNLKRIGDAAASFLGPKILADTGESNTFAWTEHLLGAPGYRIAGGSDEIQRNII
                     GERGLGLPREPR"
     gene            13710..14765
                     /locus_tag="DFR67_RS25750"
                     /old_locus_tag="DFR67_12080"
     CDS             13710..14765
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011598795.1"
                     /locus_tag="DFR67_RS25750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12080"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_110472321.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.2e-13, bitscore:
                     43.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.1e-32, bitscore:
                     104.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLELTVEQRDLESSLRSSLSRTAAGDDVWGSLLEMGLTEVPFPE
                     NYGGAGFTLKDTAVVMAELGRSLGNAPYFSSVILAGFTLLHAASDAARAQHLPAIADGS
                     VTAALVTGYPFATTSITATGGADNTIVLDGAQEAVVAGADADLLVVVAEGPSGPELAII
                     DGNVSGVVRTARESLDFTRPLARIEFTGALAHRIGGDNLAAGLVKAQAIAITALAAEQV
                     GAARACLEMSVDYAKTRQQFGRAIGSFQSIKHRLTDMLVAIELAEAAVLDAAEADTRSD
                     GELVVAAATARVLASRAATFAAEESVQIHGGIGFTWEHPLHRYFRRAKTSELLFGNTAV
                     HADTVAAALVN"
     gene            complement(14865..15704)
                     /locus_tag="DFR67_RS25755"
                     /old_locus_tag="DFR67_12081"
     CDS             complement(14865..15704)
                     /NRPS_PKS="Domain: PKS_KR (8-186). E-value: 7.8e-08. Score:
                     24.4. Matches aSDomain:
                     nrpspksdomains_DFR67_RS25755_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106968.1"
                     /locus_tag="DFR67_RS25755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12081"
                     /product="mycofactocin-coupled SDR family oxidoreductase"
                     /protein_id="WP_110472322.1"
                     /transl_table=11
                     /translation="MGGRFEGKVAFITGAARGQGRSHAIRLAEEGADIIAVDICRPIES
                     VTPFYELAEPTDLAETVRLVEALDRRIVAREVDVRDLTALTGALADGVAALGGLDIVLA
                     NAGIFISHDADGMPEEAWRDVLDINLTGVFFTAHAAIPHLKKRGGGVILLTSSTAGMQG
                     YANAPHYTASKHGVVGLMKSLAQELGPYGIRVNTVHPTGVDTPMIQNERTWGLFSPDDP
                     NPTRDAAAEAMKVTNLLPVPWIDPRDVSNLVAWLASDEARYVTASQYSVDAGAVNKP"
     aSDomain        complement(15147..15680)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS25755_PKS_KR.1"
                     /evalue="7.80E-08"
                     /label="DFR67_RS25755_PKS_KR.1"
                     /locus_tag="DFR67_RS25755"
                     /protein_end="186"
                     /protein_start="8"
                     /score="24.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAFITGAARGQGRSHAIRLAEEGADIIAVDICRPIESVTPFYELA
                     EPTDLAETVRLVEALDRRIVAREVDVRDLTALTGALADGVAALGGLDIVLANAGIFISH
                     DADGMPEEAWRDVLDINLTGVFFTAHAAIPHLKKRGGGVILLTSSTAGMQGYANAPHYT
                     ASKHGVVGLMKSLAQ"
     gene            complement(15761..19144)
                     /locus_tag="DFR67_RS25760"
                     /old_locus_tag="DFR67_12082"
     CDS             complement(15761..19144)
                     /EC_number="6.4.1.1"
                     /GO_function="GO:0004736 - pyruvate carboxylase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0009374 - biotin binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006090 - pyruvate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019664283.1"
                     /locus_tag="DFR67_RS25760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12082"
                     /product="pyruvate carboxylase"
                     /protein_id="WP_110472323.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 8.9e-10,
                     bitscore: 31.1, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="HMGL-like (E-value: 1.6e-31, bitscore:
                     102.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSKVLVANRGEIAVRAFRAAVELGASTVAVFPYEDRNSAHRAKA
                     FEAYQIGDVGHPVRAYLSVSEIIAAAKRSGADAVYPGYGFLSENAGLAAACEAEGIVFV
                     GPSAQILELTGDKSQAIAAARAAGLPVLASSEPSDDVDTLVEAAAEMRFPLFVKAVAGG
                     GGRGMRRVADPALLRESIEAASREAKTAFGDGTVFLEQAVVDPRHIEVQILADATGDVI
                     HLYERDCSLQRRHQKVVEVAPAPGLDPELRQRICADAVKFARHIGYTCAGTVEFLLDPY
                     GNYVFIEMNPRIQVEHTVTEEITDVDLVGSQLRIASGETLADLGLTQDSIEIHGAAMQC
                     RITTEDPTDGFRPDTGRVTAYRTPGGSGVRLDGSVGVGSEIGSHFDSMLVKLTCRGRDF
                     ATACARSRRAIAEFRVRGVATNIPFLQAVLDNPDFLAWNVTTTFIEEHPELLTQNVSAD
                     RGTKILRYLADITVNRPHGERPSSVYAIDKLPTIDVGARPEPGSRDRLLRLGPDGFATD
                     LRAASALAVTDTTFRDAHQSLLATRVRTRDLVTVAPHVARMTPQLLSVEAWGGATYDVA
                     LRFLHEDPWERLAALRAEMPNICLQMLLRGRNTVGYTAYPDQVTHAFVREATDTGVDIF
                     RVFDALNNIEQMRPAIDAVRETGTAVAEVAMSYTGDLADPRETLYTLDYYLRLAEQMVE
                     AGAHILAIKDMAGLLRPAAAATLVSALRSRFDLPVHLHTHDTPGGQLATYYAAWQAGVD
                     AVDGASAALAGTTSQPALSAIVAATDHTDRATGLDLAAVCDLEPYWAAVRSAYAPFESG
                     LPAPTGRVYTHEIPGGQLSNLRQQADALGLAHRFEDIEAAYAGADRILGRLIKVTPSSK
                     VVGDLALSLVGADATATDFEADPSGYDIPASVIDFLRGELGEPAGGWPEPLRSRALAGR
                     AEPRAIVPLTEADTSALGAGSRERREALNRLLFPGPTTEFESHRDSYGDTSQLSTNQYF
                     YGLRQDEEHRVQLEKGVELLIGLEAISDPDANGMRNVLCILNGQLRPVQVRDRSIETTA
                     RAAEKADRGDPGHLPAPFTGVVTLSVKEGDTVAQGESVGSIEAMKMEATITATKAGVVT
                     RVPISRGAQVDGGDLLLVVG"
     misc_feature    19351..19368
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.97"
                     /tool="antismash"
     gene            19405..21144
                     /locus_tag="DFR67_RS25765"
                     /old_locus_tag="DFR67_12083"
     CDS             19405..21144
                     /GO_function="GO:0016772 - transferase activity,
                     transferring phosphorus-containing groups [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004020491.1"
                     /locus_tag="DFR67_RS25765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12083"
                     /product="PEP-utilizing enzyme"
                     /protein_id="WP_110472324.1"
                     /transl_table=11
                     /translation="MTNEQNADTWITDWEYSERYPVYTRANAGEVLPDPSSPLNVSLVW
                     NKGLNIGWREGYVEHLGTHLASELDEVMPETLGNFGGYHFTNFSATELNGARLPGMTVP
                     EWNRLWVGDHPDLPDYVEKPGHANAELTARLAEKSAWALTTDEFPEAEQTKRRADQARA
                     NRPDLSTLSDQQLVDHARSFVPDLIFCYAYHPVTTTLSTVGPAVAGALLASIGEADKLG
                     DLLSGLGGVDSAAPSFALWDMGRLVASSEELTSLFDNGLATLLDSVDASGSPDAKQFRT
                     DFDDFLYKYGSRAPNEWDIRSDSWESKPVLALLAINGMRLSPDSSNPELIRERNETKRI
                     ALTAELAAKMPDEATRQSFLDAAKSITRFMPWRERTKTACVKVMGEMRTALYELGHRMV
                     ARGVMEDHHDVTMLLADELDAFAADPESFTETIAQRREQYLALFDLEPPFFLFEPLPLS
                     QWPKRTEHKAEIAVPGDSLAGVSGAPGVSRGRARILHDPYEAEHLEEGDIIIAPQTDPA
                     WTPLFDFAGGVVVNVGSTITHSSIVCRELGIPCAVSVQDATARIPDGAMIEVDGNTGTV
                     TVL"
     gene            21144..22091
                     /locus_tag="DFR67_RS25770"
                     /old_locus_tag="DFR67_12084"
     CDS             21144..22091
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106965.1"
                     /locus_tag="DFR67_RS25770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12084"
                     /product="TIGR03619 family F420-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_110472325.1"
                     /transl_table=11
                     /translation="MVEIGLTLPQLGEHVDAAAIRAFSTSAEELGFASLWVQEHLFYPE
                     ANESIYGGRHTTSVHPAYRSVLGATELMAFVAACTEKAMIGSSILVAGYHRPVELAQRL
                     STLDVLSGGRLVAGLGAGWSDEEHGQMDVDPRTRGRRMSELVNAVQACWGPDPVEFSGE
                     FFSIPRSVIRPKPLQQPHPPLLSGLRSAAGLARTAALFDIWNPSSGTAEALQEQLDTMA
                     GLRAGDAAPVRLFLRSYLQRPTDAVGSGGHGIEGVRGDLRTAVEAGAEQFIVEINFWDE
                     MRSTQDWADAPARLASLLETAEELSTDISKASVL"
     gene            22088..23194
                     /locus_tag="DFR67_RS25775"
                     /old_locus_tag="DFR67_12085"
     CDS             22088..23194
                     /NRPS_PKS="Domain: PKS_ER (11-362). E-value: 6.3e-20.
                     Score: 63.4. Matches aSDomain:
                     nrpspksdomains_DFR67_RS25775_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018180736.1"
                     /locus_tag="DFR67_RS25775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12085"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_110472326.1"
                     /sec_met_domain="ADH_N (E-value: 2e-34, bitscore: 110.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.1e-34, bitscore:
                     112.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAAVFDGNSPSLTIEDIPRPEPRRGEILLKVTACGVCHTDLHVL
                     KSEVKFPVPAVLGHEVSGVVEQTGEGVDNVAVGDRVVCSFIMPCGDCRHCVSGKEDLCE
                     KFFAHNRLNGTLYDGETRLGREDGTPLAMYSMGGLAEYCVVPASDAFKVPEGVGLGEVS
                     ILGCSSFTALGAINNADLVLGDRIAVIAAGGVGSSIVQFAAASGVSQIIAIDIDDEKLK
                     AVAALGATHTINSRDTDVVAEVKALTDGHGVDVAFEALGNKHTFATALDVLDDGGRAVV
                     VGIAPAGSVGEIDLARLVRRKLEIHGSYGAKARTDMPALLRLVSAGIVEPERVITRRYT
                     LDQVDEAYQALARGEIIGRAIIEMEPSE"
     aSDomain        22121..23173
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS25775_PKS_ER.1"
                     /evalue="6.30E-20"
                     /label="DFR67_RS25775_PKS_ER.1"
                     /locus_tag="DFR67_RS25775"
                     /protein_end="362"
                     /protein_start="11"
                     /score="63.4"
                     /tool="antismash"
                     /translation="SLTIEDIPRPEPRRGEILLKVTACGVCHTDLHVLKSEVKFPVPAV
                     LGHEVSGVVEQTGEGVDNVAVGDRVVCSFIMPCGDCRHCVSGKEDLCEKFFAHNRLNGT
                     LYDGETRLGREDGTPLAMYSMGGLAEYCVVPASDAFKVPEGVGLGEVSILGCSSFTALG
                     AINNADLVLGDRIAVIAAGGVGSSIVQFAAASGVSQIIAIDIDDEKLKAVAALGATHTI
                     NSRDTDVVAEVKALTDGHGVDVAFEALGNKHTFATALDVLDDGGRAVVVGIAPAGSVGE
                     IDLARLVRRKLEIHGSYGAKARTDMPALLRLVSAGIVEPERVITRRYTLDQVDEAYQAL
                     ARGEIIGRAII"
     gene            23191..23970
                     /locus_tag="DFR67_RS25780"
                     /old_locus_tag="DFR67_12086"
     CDS             23191..23970
                     /NRPS_PKS="Domain: PKS_KR (9-165). E-value: 2.4e-07. Score:
                     22.8. Matches aSDomain:
                     nrpspksdomains_DFR67_RS25780_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106963.1"
                     /locus_tag="DFR67_RS25780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12086"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_110472327.1"
                     /transl_table=11
                     /translation="MSEAPAEGLVAVVTGAASGIGRAAVEIILERGGKVVAFDTTPESL
                     DWLAGNPNAMPFVGDVTYDVDNRAAIELAEESFGRLDALILNAGVPASGSIETLDMEVF
                     DRSINVNLRAVALGVRESIPAFRRSGGGSVVITASATAMGGEPNRWPYAAAKAGVVNLA
                     RSFAIDLANDKIRVNTVCPGPISTGMTKRIEENTPERYQSLASMVPLQRWGTAREVGEV
                     IAFLASPLASFVTGASIPVDGGATCGSGQTIPIPAPA"
     aSDomain        23218..23685
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS25780_PKS_KR.1"
                     /evalue="2.40E-07"
                     /label="DFR67_RS25780_PKS_KR.1"
                     /locus_tag="DFR67_RS25780"
                     /protein_end="165"
                     /protein_start="9"
                     /score="22.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAASGIGRAAVEIILERGGKVVAFDTTPESLDWLAGNPNA
                     MPFVGDVTYDVDNRAAIELAEESFGRLDALILNAGVPASGSIETLDMEVFDRSINVNLR
                     AVALGVRESIPAFRRSGGGSVVITASATAMGGEPNRWPYAAAKAGVVNLARS"
     CDS_motif       23233..23271
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DFR67_RS25780_0001"
                     /evalue="2.60E-02"
                     /label="PKSI-ER_m5"
                     /locus_tag="DFR67_RS25780"
                     /protein_end="27"
                     /protein_start="14"
                     /score="7.4"
                     /tool="antismash"
                     /translation="GAASGIGRAAVEI"
     gene            complement(24058..25104)
                     /locus_tag="DFR67_RS25785"
                     /old_locus_tag="DFR67_12087"
     CDS             complement(24058..25104)
                     /NRPS_PKS="Domain: PKS_ER (24-267). E-value: 6.4e-09.
                     Score: 27.3. Matches aSDomain:
                     nrpspksdomains_DFR67_RS25785_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106961.1"
                     /locus_tag="DFR67_RS25785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12087"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_110472356.1"
                     /sec_met_domain="ADH_N (E-value: 1.5e-24, bitscore: 78.8,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.4e-24, bitscore:
                     79.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSAVESKFVHMIAPEVAETVVEAEPGPAPDGVVVDIGFCGICAT
                     DTHGYASAALPPAVFGHEWMGTVSAVGADVTTVEVGQRVVAGVGPACGICAQCRAGHAS
                     NCDLAFAEANGITDDAPTHGGFATKLKVSARRAIPVLDELSDEEAALMEPATVTFHAVR
                     RAQLRFGSTVVVQGAGPIGLLTAQHARTGGAGRLIISEPSAPRRAAATALGFTDVVEPA
                     DLPGMLADATNGLGADVLFECTGVAALLQPSAELVRRGGTLALLGYPGTDSSVSYGDWQ
                     SRELTVIGSLAYSHEDFAATMRLIADGRIDVKSLHTGTIGLGELVAMFRELDSGTSEHA
                     KVLVDPRR"
     aSDomain        complement(24304..25032)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS25785_PKS_ER.1"
                     /evalue="6.40E-09"
                     /label="DFR67_RS25785_PKS_ER.1"
                     /locus_tag="DFR67_RS25785"
                     /protein_end="267"
                     /protein_start="24"
                     /score="27.3"
                     /tool="antismash"
                     /translation="EPGPAPDGVVVDIGFCGICATDTHGYASAALPPAVFGHEWMGTVS
                     AVGADVTTVEVGQRVVAGVGPACGICAQCRAGHASNCDLAFAEANGITDDAPTHGGFAT
                     KLKVSARRAIPVLDELSDEEAALMEPATVTFHAVRRAQLRFGSTVVVQGAGPIGLLTAQ
                     HARTGGAGRLIISEPSAPRRAAATALGFTDVVEPADLPGMLADATNGLGADVLFECTGV
                     AALLQPSAELVRRGGTLALLG"
     gene            complement(25113..26081)
                     /locus_tag="DFR67_RS25790"
                     /old_locus_tag="DFR67_12088"
     CDS             complement(25113..26081)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004020497.1"
                     /locus_tag="DFR67_RS25790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12088"
                     /product="TIGR03621 family F420-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_110472328.1"
                     /transl_table=11
                     /translation="MTKKPFRFAAQVYRANTGQEWRDVAHKVEDMGYSALHVSDHYIGP
                     GPALDPTGHRPVTMAPITSMAVAAEVTDTLKVGCRMFCTSYHEPVVLAKEAATLAMFAP
                     DRIEIGLGAGWLGSEYDAMGIDFPSAGLRVDRLEETVELITQYLAGDEIKVDGTFVKAH
                     SFAPLPVPEITPPIMIGGGARRVLTLAGRTADIVSINFNNRSGVLGSDSVLTSTVEETH
                     KKLGWVRDGAGDRVDGIELETGAYFVAIEGQTDVTEEALIERTGFSRDELRAFPHALVG
                     SVDDICEQLEQRREEFGFSYFTIGDRAYEQFAPIVERMTGK"
     gene            complement(26111..26953)
                     /locus_tag="DFR67_RS25795"
                     /old_locus_tag="DFR67_12089"
     CDS             complement(26111..26953)
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020106959.1"
                     /locus_tag="DFR67_RS25795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12089"
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="WP_245938162.1"
                     /transl_table=11
                     /translation="MEVTPAQRILSLSHLSAIGVPPPQFIDNAAFGGFDAVGLRVAQTA
                     QDRGFQLRAGSALLRETKTALSDNGMRVLDVEVVKLHPGSSRADWSAVLEAGAELDASH
                     LLVTVLDDDYSRATDNFAELAELSGEYGLRSCLEPMVFSSVRDMTAAAKFVLDARGSDA
                     GVLVDALHFSRAGSQWSELDAIAPDLMPYCQLCDAPTDAPAADHNAAITEARTDRLAPG
                     TGALPLVELLRRLPATAAVSVEAPSARSVTDPRGWTADLGRAAREVLKAAALAPSPAS"
     gene            complement(27043..28167)
                     /locus_tag="DFR67_RS25800"
                     /old_locus_tag="DFR67_12090"
     CDS             complement(27043..28167)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1205: ABC
                     transporter, carbohydrate uptake"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024799.4"
                     /locus_tag="DFR67_RS25800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_12090"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_110472329.1"
                     /transl_table=11
                     /translation="MKTTRWTKAFVAVVAASMFATACSSSDDGGSGQAADVSGAQAVAD
                     QYEAAPAGLVLDTPLSKAPVAGKYVISIETPQPISSAKNDAIQQAADLLGWRYQRITMG
                     TDAEAAGKAIDQAIALKPDAIHMSGTPLSMVAKQIESAKAAGIPVIADSVSGEPIPGVI
                     STSLDGDGQVQEWGKMVASQVVAESEGKANVAIFTITDYPILNIFTDAFTAQMKAQCPD
                     CKVELVNQQVADLGTKTPQSVVSTLQRDPNINYAVFSFGDLVLGVDAALRGAGLQDQVT
                     FAGQTPTPDNLKSLKDGDNSVWVGFPVQILGWRVIDMLARQFNGDDLAPADAAFLPTQL
                     LNAENIDSAVIDADTGYWVGVADYQDQFKALWLK"
     misc_feature    28207..28222
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.2"
                     /tool="antismash"
     misc_feature    28215..28235
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.09"
                     /tool="antismash"
ORIGIN
        1 gggatctctt cgatcgggac gtcggtacgg ttgccctccg gcggcacgat cttcgcgatc
       61 tcgccgccgc gcgaatcgac caccgtcgcg atctggctct gcttgatgtc gccgggtgcg
      121 ggcacggaca ggtctgcgta ggtgaacagg aacactgccg ccatcaccag gacgaacccc
      181 ggcagcaatg cgccgccgag gccgatgatc caggcgatga ccttgtggat gcgtcgcttc
      241 ttctggaccg gggtccggcc agccgaagcg ggacgtccgc cgtcgtgctc cgaggtccaa
      301 ctggacctgt tcggtccgtc agggccactg ttcacagata cttctccata ccttcggtac
      361 ccagtacttc cgggccaccg gcgatgtcca cttgcgcgga cccaccggct gaattgtttg
      421 ccacgcgtcc accggccacc cggcgactac gtcgcacgcg tggccgtggc ggcagtccag
      481 atacgtacga ctggaccaaa tggttccagc tacacgtccg gcacacctcc accacatgta
      541 ccgagaactc ctcctggctc actgccaggt gcaggatctc ctcggtcgtc cgggctgatc
      601 ccgacacctg cccgagtttc tcgccgaaca cccacgacac gatggtgacc tgctcttttc
      661 tgcagatcgg gcaccgcgtg gcggacggtc gaccgtgaaa cttggccgca cgcagcagat
      721 aggggctggc gtcgcagact tcggcgaccc cggtacgtcc ggagtacacc tcggccagcc
      781 gagacttgcg ctgtaacgcg tagtccacca cctgtcgctg caatcgcact cgtcaagagt
      841 acgtggcacg gcgaaaccca tgtctgcggt tgtccgaccg gacgcccggt tcggcacggt
      901 ccacggaggt catctcagcg ctgtgtggcg gaaacgtttc cgatcaccgc agttcagacg
      961 cagtttccga cccggttata tcggcgcgat acattcgggt gtactgtttg gcacacaggt
     1021 ttctgcaaca cgttgaatgg aggtgtaatc ccgatgctcg aactcgcagt actcggcttg
     1081 ctcctcgagt ccccgatgca cggctatgag ttgcgtaagc ggctcaccgg tctgctcggg
     1141 gcgttccggg cgttttcgta tggatcgctg tacccgtcgc tgcgacgtat gcaggccgac
     1201 ggtttgatcg ctgaggatgc ggcccccacg ggaacgctca aacgacgcgc tcgtcgcgtc
     1261 tatgcgctga cccccaaggg tcgtgaacgg ttcgcagaac tggtcgcgga cacgggtcct
     1321 cagaactaca ccgacgacgg cttcggagtg catctcgcat tcttcagccg gacccccgca
     1381 gaggcgcgga tgcgcattct cgagggtcgt cgccggcagg tggaagagcg ccgcgaaggt
     1441 ctccgtgaag cagttggacg ctcgaaccgc acagtcgatc gctacacgaa gcagctccat
     1501 caactgagtc tcgaatccag tgaacgtgaa gtccgctggc tcaacgagct catcgccgcc
     1561 gagggatcgg agcgagtcga ggacccgaca gcagtgtcga gaaaccccgg cccacttccg
     1621 accgagacgg tccatgcaga acccgaaaca acctcagtta caccacacaa agaaggggaa
     1681 cccgaccatg ggtgacaaca ccaattcagt tcgcgtggcg attgttggcg tgggaaactg
     1741 cgcctcatcc ctggtccagg gcgtgcagta ctaccaggat gccgatgaga acgcagtcgt
     1801 tcccggcctc atgcacgtga agttcggcca gtaccacgtt cgcgacgtgc agttcgtcgc
     1861 cgcgttcgac gtggatgcca agaaggtcgg attcgacctc tccgacgcca tcttctccag
     1921 cgagaacaac accatcaaga tcgctgacgt gccgccgacc ggggtcaccg tccagcgtgg
     1981 gcacaccctc gacggactcg gcaagtacta ccgcgagacc atcaccgagg ccgatggcga
     2041 gggcgccgac gtcgtccaga ccctgaagga cgccaaggtc gatgtgctcg tctcgtacct
     2101 gcccgtcgga tccgagcagg ccgacaagtt ctacgcgcag tgcgccatcg acgcgaacgt
     2161 cgcgttcgtc aacgcactcc cggtcttcat cgccagcgac cccgtgtggg ccaagaagtt
     2221 cgccgacgcc ggcgtgccga tcgtcggaga cgacatcaag agccaggtcg gtgccaccat
     2281 cacccaccgc gtcatggcaa agctgttcga agaccgcggc gtcaccctgg accgcactta
     2341 ccagctgaac gtcggcggca acatggactt caagaacatg ctcgagcgtg agcgtctgga
     2401 gtccaagaag gtctccaaga cccaggccgt gacgtccaac ctgaccggtt cgctgtcggg
     2461 caagatcgac gacaagaacg tgcacatcgg cccgtccgat cacgtcgcat ggctcgacga
     2521 ccgcaagtgg gcctacgtcc gcctcgaagg ccgcgccttc ggcgacgtgc cgctgagcct
     2581 cgagtacaag ctcgaggtct gggactcccc caactcggcc ggcatcatca tcgacgccgt
     2641 gcgtgcagcc aagatcgcca aggaccgtgg catcggtgga cccatcctcc ccgcctcggc
     2701 ctacctgatg aagagcccgc ccgagcagct cgccgacgac gtcgcgcgca cccagctcga
     2761 agcctttatc gtcggcgcag acgcctgatc tgatctagac gttccacacc aagagccgca
     2821 cacctgcaaa ggtgtgcggc tcttggcatt cgagggtgta gaactcccgg ccattgactt
     2881 caagtcaact tgaggtccta cgctcctgcg atgacccaga actcagcagc gacgacgccg
     2941 aagacgtctg acctcaacag catccgagca atcatcgaag acgtacaggc cggattcaat
     3001 cgcaacgacg ccgacctcat gaacgttcac ttggccgagg acgccatcat cgtgaacgcc
     3061 cgcggtgtga ggctcacggg gcgtccggcc atcgacgagg cgacacgcga gggtctggcc
     3121 gcaggtttcc tgcgcgatgc caccgcgtat taccaactca ccgacattgc actgctggcc
     3181 cccgacgtca tcacggccgg caagaacgct tggtcgaccc agcaggattt cgaggtaggg
     3241 aacccgccgg aaatgaatgc gctctacatc ttcatccgcc gatcaggccg ttggctgatc
     3301 tggcgtcggc agaacacctt gatcgcgtga gtttcagcga ccactgtgac ggtgaaggtc
     3361 aagcaacgca gggccgagcc gatactcgca gtatctattt gctatcgtaa tctcacactt
     3421 caggggagga actttgatga gtggtcgatt caagagcttg gttgccggtg ttgctgtcgc
     3481 cgcgacgatc ggcgtgggtg gcggcctggc ggtgggcaca gcgccggcca cggccgtgac
     3541 cgtgcgggaa actcagggga tctgggtcat cacgctcaca catgaggaga cggtggccgc
     3601 cgcccaggtc ggtgcgggca atgtgatcaa tgccgtgctg ggcaacgacc actggcgggt
     3661 gacgttggac agcgattcca aatacgcagg cggtagttac taccgaccgg acaaaggccg
     3721 cacgtggagc aatgtcaccg gccaacaggt gatctccgaa gccgccgccc accggaacgg
     3781 gtacgtggtg ctcggagtgt tcccagacaa cccggacatg cctttgtggg tcgcgcaagc
     3841 ctggtaagtc cgccccgcac gccccgcgcg tgcgcagtca caacaacaca ccgccggaaa
     3901 tctcgatgcg ctcacccgtc gcccagcgga gctcatgaga gacgagggct gagatcgcgt
     3961 cggcgatgtc agtcgggtcg cccacgcgcc cgagagcggt ctgtccggag agtgccgcgc
     4021 gcatggcttc gctgtcgcgc atggctccac cgttgaagtc ggtcgcggtc gggccggggg
     4081 cgatcgaatt gatccgaatg cctcgcggcc ccagttcgag agcaaggctg cgggtcagcg
     4141 cttcgagggc cttcttcgac gccgcataga cggaggtcgc cgggctgacg tgtcgactga
     4201 gcgaactcga cacgttcacg atgcttgccc cgtccgacag gtggggcaag aaggcttgcg
     4261 tgacgaacag tggaccacgg acgttgaccg cgaaggtggc gtcgaagtct tccgccgtga
     4321 tgtcgccgag cggcgcgaac aggcccaccc cggcgttgtt gaccagcacg ttgatggtgc
     4381 ctgcgtccca ttcctgtctg atgccggcga gcacagcgac gcgagcgtcc tcgatcgagg
     4441 agaggtcggc cacatccatc tggaccgcga tcgcctcgcc gcccgattgg acgatgtcgt
     4501 ccacgacctc gcctgcaccg cctcgagagg ccgcgacgac tttgatcttg cgctcggcca
     4561 aagccagtgc ggtggctgct ccgagtccgc ggttggcgcc tgtcactagg gctacacggg
     4621 tcatgacgcc tcctggtcag ttaagtaaat ggatacttac ttgtaaggta gccctgacag
     4681 caaaacccgt caattcaaag caggagaaag acgatggccc gcgacgccga agccaccaga
     4741 gagcggatcc tcgctgctgc caccgacgag ttcgccgcac acggatatgc gggtgggcgg
     4801 gtcgagcgga tcgccaccaa ggcgcagagc aacgttcgga tgatctacgc gtactacggc
     4861 ggcaagagcg gtctgttcga tgcagctctg gcggaggcgt tgcgccgcat ggccgaggac
     4921 gtcccaccgc gccccgatga ccttgccggc tgggccggtg acgtgttcga ccatcatcag
     4981 cgcttccccg aaatactccg gctgagtatg tgggctcagc tcgagcggcc cgaggccacc
     5041 gctgagccga gcgaggtcta tcggaacaag gcgctcgccg tcgcaacggc cgcggcgcaa
     5101 ccgttgtcgg ccgtcgacgt cctggtcttc atctacgcca tcgcgcaggc ctggcagctc
     5161 tcaccacagg gactcaccgg actcgatgag aatccaggca gcggtcatga catcgccgct
     5221 cgccggcaat cggtcgtcac cgctgtcgag cggatgctgc aagctcaatc gatgaacgga
     5281 agcaacgaat agcggggcga cctcgtgacc tctcgccgac gaccagcccg tattctgccg
     5341 atgtgtcgag gtcggtagag cagtgggcag cacagttgca gcaactggac cgcagcgagt
     5401 ggctcgcgtt tctggactcg aactcgggcc tacctggccc gcgagcaaac acatcattgg
     5461 ccaccgcatt ggcgcacctc gccgatccgg gcatggttga tcaacttctg gcaagcgatg
     5521 acgaatacca gatgctctgc ggcgctgtct gtctgggcgc gcaggtcgtc gaccctgagg
     5581 tgcgggcgaa gctccgggta ctcgctgtcg atgaacggtg gcgggttcgc gaaggcgtgg
     5641 tgatcggcat ccaagaagca gccgacaccg atctacccgc cgtgcagtcg gtcgtactgg
     5701 actgggccgg cgacccagaa cccctgatgg cccgcgctgc cgccgcggcc atatgcgaac
     5761 cgcggctgct gcgctcacct gaggcagccg ccattgccat cgacgtatgt cggcacgcga
     5821 cggcggtatt ggtcgcccta cccggcaccg cgcggcgctc cgcggcagca cggtctctgc
     5881 gtcaaagcct cggatattgc tggagcgttg cagtggccgc cgacccgaca gcactggccg
     5941 agttcaaggc cctcgacaac acagacccgg acgtcgagtg gatcgtccgg accaacctca
     6001 agaagaagcg actggcccga ctcctctgac ctgggcggaa ggccgctcgg gacctgagca
     6061 cggtcagcca taacacggct catggagctc atgacaagat ggaccgtgcc ggtagaaacg
     6121 atgccgcctt cgctcgcggt ggcattcatt gcccgggcgg tgacctgtag acaactgtga
     6181 agggaagccc gcctgtgcgc acagaagaca acgactccgt cgtcatcggc ggtgggcaga
     6241 tcgccggcac tgcagcgttg accgtggtga ccgtcgaacg tgaccaactg gtcatcgtga
     6301 cagtgcaggg cagcgtcgat gtcctgaccg caccgcagct gtccgaggca gtcgacaacg
     6361 ctctcaccgg cgaaccacga ggcctgatca tcgacctgtc gaccaccgaa ttcctggcct
     6421 ccgcgggcat gtctgcgctg gtcgcagcgc acgaggcgat cgccccggcc ggcaagctcg
     6481 gagtcgtggc agacggccca tccaccgcgc gaccgatccg cctggtcggt ctcgaccaga
     6541 cactgaccct ctaccccacc ctcgaggacg ccatcggggc catgacctga tcgcgcacac
     6601 atagggtcgc gcagtaacca gggacgggtc gttgcgtgga ccaattggtt catgttagat
     6661 cgaagagatc cgatcaacta tgtcgacaag gaacccgtgc cagcacacat cgctactgct
     6721 ccacccgtcg cccatgccgc acttctaggc ctcggggtgt accggccacg tcgtgttgta
     6781 cccaactcag aactggtcga ccagatcgac tccactgacg aatggatccg gtcgcgttct
     6841 ggcatcgagt ctcgtcggtg ggccggggcc gacgagacaa tcgtctcgat gagcgtggcc
     6901 gctgccgccg atgcgcttgc cgcgtccggc ttggccgccg atcagatcga cgcggttgtt
     6961 ctcgcgacgt cctcgcagat ggtgctggga ccgtctgccg gagcggtcgt cgcaacggaa
     7021 ctggggatgc atgacaccgc cgcctacgac atctctgcag gctgcgccgg attctgttac
     7081 gccctgggca acgcagcagg ccttgtacgg gcaggccagg cgcggcatgt gctggtgatc
     7141 ggggtggagc ggttgtccga ccttctcgat cccaccgaca ggacctgcgc gttcatcttt
     7201 gccgatggcg caggtgcggt tgtggtgggc ccatcggact cagagggtat cggtccgacc
     7261 gcatggggtt ccgatggaag tcaaaccgat gcgatcaagc aggacaaaga ctttcaagag
     7321 tacttcgctg aggtcgcggt tgccgcggac ggtggtgcag cagcggagcg tccgtatatc
     7381 cgcatgaagg gccaggccgt attccgttgg gctgcgacct ttttggacaa ggcgggacgg
     7441 gacgtcctgg acaagtccgg cctcactgtc gatgacctgg acgcgttcat accgcatcag
     7501 gccaacagtc gtatcactga cgccctgatc cgggtgctgc atatgcccga ctcggtcgcg
     7561 gtcgctcggg acatcgtcga gaccggcaac accagcgcag catcgatccc catggcgatg
     7621 gaacaggtca tccgttccgg ccaggcccgg cctggagaca ccgcaatgct gctcggtttc
     7681 ggagcggggt tggcttacgc cgggcaggtc gtccgactgc ctgcgatcgt ctagcgaaag
     7741 ggtcccgacc agcgccgtag gcatcgctca ttcgtcgttc gcagcacccc tgccggcaac
     7801 gatgagtcgt cgatgcgtct gcacctcggg ccccagcggt agaaggttgc gaacgagttc
     7861 atccccaacc aggtgcagtt cgtcgtcggt catcgggtcg agcgcatcga gaatgaacaa
     7921 cgcagtggtc gtggcgtcgt tcaattgggt acgccgacct tgacgccagt tccaccgccg
     7981 gcaggtcacg ccgatgtcgt cgcaccacac cacctcaccg gcggtggggt gttcggtcac
     8041 gtcttcgccg gcggcggtgg tgtcgaactg ctcgctgcca tctgcgcgga tcagccgagg
     8101 ggcgccgcga tagcggccca gatcctcacc cccgagcggg atctgatgga tgaccgagat
     8161 cgcgttgtag acgtcggtca gccggttcac gcgcggcagc ccggactcgg cacgccggag
     8221 caacgcctcc gcgctgttac gggtgcgctg gggttttgct ccgaacgcgc gatacgcctc
     8281 acgccaggaa gccatgtgcg gcaactcttc caccggatac tgggccaggg cgagacgcgc
     8341 ggactcctcc gcctcctgca gcaacgcttc actcgtgtcg tcactgggac cggggaccaa
     8401 tccatcaacc gcgatcaaca gggcgcggta gtccgggcgc agatcgaaga ccgcctcgtc
     8461 gacgccggcc ctgctcaaca cgtcaaagtc gctcataatg ttcatccttc ggcggagtca
     8521 gttgcgttgc cgagcatatc cctcggacta ccgcgcatct gtcgtcgccg ggggtccgat
     8581 caacgacgaa gacccaccgg gagtcggtgg gtcttcgtct cgtcaggggt agtgcccggc
     8641 ttcggatcag ccgacgaccg tggtgtcgta gtaaccgtcc ccgtcggtgt cgacatgcac
     8701 ggtgtcgatg tagccgtcgt tgttggcgtc ctcatgcatc tcgtcggcca tgccgtcgcc
     8761 gtcggtgtcg tactcctcgt agttcgcgat gccgtcacca tcggtgtcgg tgagtgccgt
     8821 gtcgacgatt ccgtcggcgt tggtgtcgta gtactcggtg gccatgatgt tctcctcgct
     8881 ggtgtgtggc tttcggggat aggagtgacc cacaccggcg aatgttccct gcacgctgcg
     8941 aggtcagccg aacgctcgac acgcgcatct caccctgaaa accggccaac aaaagaggcc
     9001 ggagggtaaa tacccctcgt cgagccgcta cgtaccggtt ttcagggcag gccctacagc
     9061 tgccagtgca ccggctggga gatgatgtcc gccagccgcc tgcggtagta cttggccgac
     9121 tcctcattga acgcgctcat cgtcttcgcg gtcgccgcgg cgtcacgagc acgcatcgca
     9181 tcgaggacgt cctgctgcat ctccaccgcg gccagcctgg tggccatcgg atgctcattg
     9241 ggttcggcgt cgcgcaccag taaccacagc gtctccatga cgatcttcag tgcgggattg
     9301 ccggccgcct cgtacacgca ccgctgaaag accgcgttgt tctcctggaa gttcgcgtag
     9361 tcgcccggat cttcacgcat cctgtcgagc gcggtctgca tgacctcgat ctgctcgtcc
     9421 gtgacgttct ccgcggcagc gcgggccacg atgggctcca gcatcaaccg gacgtcgatc
     9481 acgtcgctga tgttggcgct gtcgatctgc aggaacagct tcatcgtgtt ccccagcgat
     9541 tcgagctcgg gccgcttggc gaccgggcca ccgccgatgc cggacttgat ggtcaccagg
     9601 tcccgactct cgagcagacg cagcgcctcg cggaccgtcg tgcgggcgac cccgtgctcg
     9661 gccaccatct ctttctcggt cggaagccgc tgaccgacca cgatgccgcc ggtgaggatc
     9721 tgatccgcga tgacgttcgc gattttcgcg gacatcttct gtccgcgtat acgcggccct
     9781 actgtgtctt ctgcggtcat atctccccca tggcgatcag ctggcgctgt gtggtcacca
     9841 gcgcgttcgg ctcgtacgct gacaacactt ccagcgttct ggcattgcgc ccaacagtac
     9901 ccatccgaac tgtgacgtgg atcaagtctg tacatagtta gcgaaattag atactgtagc
     9961 caatgtcagc aaagtaccca gcgcggcaca ggaggtagcg atgttgccaa cgcggccacc
    10021 gaaacccgaa ctggcacaat catttcgcga cggcggacac tggaccgatc acccgatcgg
    10081 ccactttctg acccgtgcag cccagcgcta tccgatggcg accgcggtgg ccgacggcga
    10141 ccgccggctc acgttcgccg acatcgacct gcaggcaacc cggctggcgg ctgctctgcg
    10201 cgcccgcggg gtcaccgcgg acgacgtggt gtcctttcag cttcccaact gcgccgaggc
    10261 cgtcatcgtc ttccaggccg tcatgaagct gggcgccgtc gccaacccaa ttgtgccgat
    10321 ctaccggtca cgggagttgc ggttcatcct cggccagtcg cgtgccaaag tcgtgttcat
    10381 tgccgccgaa ctccgcggtg tcgacgtcga cgagatgtat cgggacctcg ccgcagaact
    10441 tccggacctc gaatggatca tctcgctcgg agagacctcg gccggcggtc tcgccgtcac
    10501 ctgggccgac ctcatggact cggtcagtac ccagatggtc aaccagacaa gggccatcgc
    10561 gccgccggca gctgacgacg tctgcctgct gctgtacacc tccggcacca ccgcagatcc
    10621 caaaggggcc ctgcacagtc acaacaccct ggtctacgag aaccggtcga tgatcgactg
    10681 gttcagcctc aacgagaccg acgtgatctt caacccctca cccgtcacgc atgtcaccgg
    10741 catcaactgc gcattgatcc tccccttcgt actcggcgca cccgttgtcc tgcaggacgc
    10801 ctgggatcca gcggtcgcac tccagcgcat cgtcgacgag cattgcagct tcatgatctt
    10861 ctccaccccg tttctgcgtg ggctgctcga tgtctccgaa tcaaccggca cacccacacc
    10921 ctcgatccgg tacatcgttt gtggcggcgc cgacatcccg gacgcactca ccgcagcagc
    10981 caccgatcgt ctcgggacgg tggtgcggat gtatggcgcc accgagggtc cgtcggtcag
    11041 taccgccgat cgctgggacc ctctctacct ccggatcagc accgacggac ggccgatggg
    11101 cccgaccgaa ttggtggtgg caggtggtaa cggcggtctc gcacaggtcg gcgaggtcgg
    11161 cgagatcatg tggcgtggcc cggacacctt tctcggctac ctcgagtccg ctctcaacgc
    11221 agcggctttc actgctgacg gattcttccg gaccggcgat ctcggccggt tcgacagcag
    11281 cggcgcaatc cacatcgtcg gtcggatcaa ggacatcatc aaccggtcgg gcgagaagat
    11341 cagtgcccac gatgtcgaga atcagctcag cgaacacccc gctgtcgtcg aggtcgctgt
    11401 cgtcgccggc ccggaccctc gaaccggtga acgcggatgt gcgttcgtgg tgacccgcga
    11461 tcacagcgac ctcacgctcg gagaagtcca ctcatttctt ctcgaacgcg agatcgccgt
    11521 ccaaaagatc ccggagagcg ttttcgtcgt cgattcgctg ccgaagacgg ccagcggcaa
    11581 ggtacagaag ttcgcactgc gcgactggac ccgcgaccgg gatgctcttc caccgcagat
    11641 ggcgacgatg acgttcgccg caacacacga gaaatagggg ccgaatgact gttcagacgc
    11701 ctggcatcga acacctcgtc gtcaccgagc cggaaccggg tatcgcactc gtcgagctgg
    11761 cccgcggcaa ggtgaacgcg atcgacaccc agatgtacga cgagatcgca gaagtattcg
    11821 acacgttgtc cgacaaccag gacatccgtg ccatcgtgct caccggccgc ggccggatct
    11881 tctgtgcggg caatgatctc ggaagcttcc gggtgatgga tgcggtcagt ggcgacgtcg
    11941 agatgcgcgg cgtgcgacgc gcgctcttcg gcctctacga ctgtgcgcta cccgtcatcg
    12001 cagccatcaa cgggccggcg ctcggcagcg gacttgccct ggcatctctc agcgacatcg
    12061 tggtcgcctc cgaccgggcc acgttcggtc tgccggagat gggagtcggt gtgctcggcg
    12121 gcggccgctt caccgccaga atgcttccgc aacaggcgat gcgccggatg ttcttcaccg
    12181 ccgaacccgt cgatgcccag accctgagaa gctggggtgc gccgctcgac gtggtacctc
    12241 acgacgacct tctcgaggtc gcgatgtcgc gggcgcgcgt catcgccgcg aagagccgat
    12301 acgcactgac cctggcaaag caatcattga acgggtgcga agacgtcgac ctcaaacgcg
    12361 gctacgaact cgaacagacc ttcaccgtgc gactgtccga gcaccccgac tccaagaagg
    12421 cagtcgaggc ccggatcgcg gagatgacga aaggaaagaa gtcatgacgc cgacacccgg
    12481 atccagcgga tcagctgcag cacaggtcat cgacgtcgac gcgttctcag agaagtgcgt
    12541 cgcatggctc gacgagcacc tcgaccggcg tgagaccgga tcgtcggttg ctgcagaccc
    12601 gaactacgcg atcttccaca accacaccca cgacgaggaa cgtgccctga tcgacgctgc
    12661 ccgcgcttgg cagcggaaga gggtcgacgc cggcttcggt gccatcacct ggggtccgga
    12721 atggggtggc gcaggactga ccgccagcca cgaacgggtg tacgtcggtc tcgagcggca
    12781 gtacaacacg cccgaccggc acgagaccgt gctcgtcacc gtcgaattgg tggcccccac
    12841 cctccacgtc ctgggcaccg aggatcagaa aaagcagttc gtcgaaccct tcctgcggac
    12901 cgatctcctc tgctgtcagc tgttctcgga gccgggcgcc ggatccgatc tcgccggtct
    12961 gtcgaccaaa gcagtcaggt ccggcgacac ctggcggatc aacgggcaga aggtctggag
    13021 ttcgggagcg cagttctccg agtggggcct gctcatcgcc cgcaccgaca cctccgtggc
    13081 caaacaccgc ggaatgacgg ccttcatggt gccgatggac gcgcccgggg tcgatgtgcg
    13141 acccattcgg cagagttccg gcgggtcgac attcaacgag gtcttcctca ccgacgtcga
    13201 actgccggac acgatgcggg tcggtgccga aggcgatggt tggaaggtgg cgctcacaac
    13261 gcttggcttc gaacgtaatt caagcgcagg catcgtcagc gcgggcggca acagcgccga
    13321 tctggtgcga ctcgccaaga gtttgggcat caccgacgat ccgctggtac gacaacagct
    13381 ggcagacgcc gcgatctacg agcgcgcctc ggcactgatg gtggctcgtt acgccgagcg
    13441 cgagcagtcg ggggccgttc cgggagtgga gggttcgatc ggcaaactcg tctggaccca
    13501 gaacctcaag cgcatcggcg atgccgccgc gtcgttcctc ggcccgaaga tcctcgcgga
    13561 caccggagaa tcgaatacct tcgcctggac cgaacatctc ctgggcgcgc ccggctaccg
    13621 catcgcgggt ggctccgacg agatccagcg aaacatcatc ggcgaacgcg ggctcggact
    13681 gccccgcgaa ccacgttagg agtgcggcaa tgcctctcga attgactgtc gaacaacgcg
    13741 atctcgaatc aagtctccgg tcgtcgctgt cgcggaccgc agcaggcgac gatgtctggg
    13801 gttccctgct ggagatgggt ttgaccgagg tcccattccc ggagaactac ggtggcgccg
    13861 gattcacctt gaaggacacc gcggtggtga tggccgaatt gggtcgatca ctcggcaacg
    13921 ctccatactt ctcctcggtg atcctggccg gcttcacgct gctgcacgcc gcgtcggatg
    13981 ccgcccgagc acagcatctg ccggctatcg cagacggcag cgtgacggcc gctctcgtga
    14041 ccggttaccc gtttgcgaca acgtcgatca cggcgaccgg tggtgccgac aacacgatcg
    14101 ttctcgacgg ggcgcaggaa gccgtggttg ccggggcgga cgctgacctg ctggttgtgg
    14161 tcgccgaggg accgtccggc ccggagctgg cgatcatcga cggcaatgtc agcggtgtgg
    14221 tccgcacagc acgggagtcc ctcgacttca cgaggccgct cgcgcggatc gagttcacgg
    14281 gtgcactggc ccatcgcatc ggcggcgaca acctcgccgc aggtctcgtg aaggcgcagg
    14341 ccatcgcgat caccgcactc gccgccgaac aggtgggcgc agcgcgcgcc tgcctggaga
    14401 tgtccgtcga ctacgccaag acccggcaac agttcggtcg tgccatcggg tcattccagt
    14461 cgatcaaaca ccggctcacc gacatgctcg tggcgatcga actcgccgag gccgcggtac
    14521 tcgatgccgc cgaggccgac acccgcagtg acggtgagct ggtggtcgct gccgcgacgg
    14581 cccgtgttct cgcctcacgg gccgcgacgt tcgcggccga ggagtccgtg cagatccacg
    14641 gcggtatcgg attcacctgg gaacatccgc tgcacaggta cttccgccgg gccaagacga
    14701 gcgaactgct cttcggcaac accgcggtcc acgcggatac agttgctgcc gcgctcgtga
    14761 actgaaccaa acgatccacc tatacgaaga cgagccacct gtaggtggct cgtcttcgta
    14821 tttccggctc gtttgtgcag tgcagcagca acgtcagtgc gcgatcacgg cttgttgacc
    14881 gcgcccgcat cgacggagta ctgcgaggcc gtcacgtagc gcgcctcgtc ggaggccagc
    14941 caggccacga ggttgctgac gtcgcgtggg tcgatccacg gcaccgggag gaggttggtc
    15001 accttcatgg cctcggcggc ggcatcgcgg gtgggattcg gatcatccgg cgagaacaat
    15061 ccccaggtcc gctcgttctg gatcatcggg gtgtccacac cggtcgggtg aaccgtgttg
    15121 acccggatgc cataggggcc gagttcctgc gcgagactct tcatcaaccc gacgacgcca
    15181 tgcttactcg ccgtgtagtg cggcgcgttc gcgtagccct gcattccggc agtggaactg
    15241 gtcagcaaga tgacaccgcc tccccgcttc ttgaggtgcg ggatggcagc gtgcgcagtg
    15301 aagaagacgc cggtcaaatt gatgtcgagg acgtcgcgcc acgcctcttc gggcatcccg
    15361 tcggcgtcgt gactgatgaa gatacccgcg ttggccaaca cgatatccag cccgcccagc
    15421 gccgcaacgc cgtcggcaag agcaccggtc agcgccgtga ggtcgcggac gtcgacctcg
    15481 cgcgccacga tccgcctgtc cagagcctcg accaggcgca cggtctcagc caggtcggtg
    15541 ggctccgcca actcatagaa aggcgtcacg ctctcgatcg gccgacagat gtcgaccgcg
    15601 atgatgtccg caccctcttc ggcgagacgg atggcgtgtg aacgcccctg cccgcgtgca
    15661 gctcccgtga tgaaggcgac tttgccctcg aaacgaccac ccatgtgttc tcactcctca
    15721 tatttgcgtt tacaaacgtt ggcaatcgac tgatgactgt tcagccgacg acgagcagca
    15781 gatctccgcc gtcgacctgg gcgccccggc tgatcggaac cctggtgaca acccccgctt
    15841 tggtggcggt gatggtcgct tccatcttca tggcctcgat cgaacccacc gactcaccct
    15901 gggcgacggt gtcgccttcc ttcaccgaca gcgtcaccac accggtgaac ggcgccggca
    15961 agtggccggg atcgccacgg tcggccttct ccgcagctcg tgcggtcgtc tcgatactgc
    16021 ggtcccgcac ttggacgggc cgcaactgtc cattgaggat gcacaagacg ttacgcatgc
    16081 cgttggcgtc cgggtcggag atcgcctcga ggccgatgag cagttccaca cccttctcga
    16141 gctggacccg gtgctcttcg tcctggcgca gaccgtagaa gtactgattg gtcgacagct
    16201 gcgacgtgtc gccgtagctg tctcgatgcg actcgaattc cgttgtcggg ccggggaaca
    16261 gtaaccgatt cagggcttcc cgccgttcgc gcgatccggc gccgagtgcc gaggtgtccg
    16321 cctcggtcag cggaacgatg gcacgcggct ccgcgcgacc ggcgagtgca cgcgagcgca
    16381 gtggttcagg ccagccgccg gctggttcgc cgagctcacc acgcaggaag tcgatcaccg
    16441 acgcggggat gtcgtagccg gagggatccg cctcgaagtc cgtcgccgtg gcgtcggcac
    16501 ctaccagcga cagagccaga tctccgacga ccttcgacga cggggtcacc ttgatcaacc
    16561 ggccaaggat ccggtcagcg cctgcgtaag ccgcctcgat gtcctcgaag cggtgggcca
    16621 gcccgagggc gtcggcctgc tgccgcaggt tggacagttg gcctcccggg atctcgtggg
    16681 tgtagacccg cccggtgggt gccggcagtc cggactcgaa tggcgcgtac gccgatcgca
    16741 ctgccgccca gtagggttcg aggtcacaca ccgcggcgag gtcgagtccg gtcgcacggt
    16801 cggtgtgatc ggtcgcggcg acgatcgccg acagcgcggg ctggctcgtg gtgccggcga
    16861 gtgcagcact ggcgccatcg acggcgtcga cgccggcctg ccaggccgcg tagtaggtcg
    16921 cgagctgtcc gcccggcgtg tcatgggtgt gcaggtgcac cgggagatcg aagcgcgaac
    16981 gcagcgcgct gacgagcgtt gcggccgccg ccgggcgcag cagcccggcc atgtccttga
    17041 tggccaagat gtgtgcgccc gcctcgacca tctgttccgc gagccgcagg tagtagtcca
    17101 gggtgtacag cgtctcccgc ggatcggcga gatcgccggt gtacgacatc gccacctcgg
    17161 cgaccgccgt gccggtctct cggacggcgt cgatggccgg tcgcatctgt tcgatgttgt
    17221 tgagtgcgtc gaagacccgg aagatgtcga ctccggtgtc ggttgcctcg cggacgaacg
    17281 cgtgggtgac ctgatcgggg tacgcggtgt acccgacggt attgcggccg cgaagcagca
    17341 tctgcaggca gatgttcggc atctcggcgc gcagcgcggc gaggcgctcc cacggatcct
    17401 cgtgcaggaa gcgcagggcg acgtcgtacg tcgcaccgcc ccaggcctcg acggacagca
    17461 gttgcggggt catgcgcgca acgtgcggtg cgacggtgac caggtcgcgc gtacgcaccc
    17521 gggtagccaa cagcgactga tgcgcgtccc ggaacgtcgt gtcggtgacg gccagcgcgg
    17581 acgcggcgcg caggtcggtt gcgaatccgt ccggacccag ccggagcagc cgatcacggg
    17641 atcctggttc cggccgggca ccgacatcga tggtgggcaa cttgtcgatg gcgtagaccg
    17701 acgacggtcg ctcgccgtgc ggccgattga cggtgatgtc tgccaggtat cgaaggatct
    17761 tggtgccacg gtcggcagag acgttctgcg tcaacagctc cgggtgttct tcgatgaacg
    17821 tcgtcgtgac gttccaggcg aggaagtcgg gattgtcgag aaccgcctgc aggaacggga
    17881 tgttcgtcgc gactccgcgg acgcggaatt cggcgattgc gcgtcgagac cgggcacagg
    17941 ccgtggcgaa gtcgcgcccg cggcaggtga gtttcaccag catcgagtcg aagtgcgagc
    18001 cgatctccga gcccacgccg acgctgccgt ccaggcgaac cccggacccg cctggggtgc
    18061 ggtaggcggt cacccgcccg gtgtcgggcc ggaagccgtc ggtcgggtct tcggtggtga
    18121 tgcggcactg catcgcagcg ccgtggattt cgatcgagtc ctgggtcagg ccgaggtccg
    18181 cgagcgtctc accggaggcg atccgcagct gcgaacccac cagatccacg tcggtgatct
    18241 cctcggtgac ggtgtgctcc acctggatgc gtgggttcat ctcgatgaac acgtaattgc
    18301 cgtacggatc gagaaggaac tcgacggtac cggcgcaggt gtacccgatg tgccgggcga
    18361 acttcaccgc gtcggcgcag atgcgttgac gcagttcggg atccagtccc ggcgcaggtg
    18421 cgacctccac caccttctgg tgccggcgct gcagggagca gtcccgctcg tacagatgga
    18481 tcacgtcgcc ggtggcgtcg gcgaggatct gtacctcgat gtggcgaggg tcgacgaccg
    18541 cctgctcgag aaataccgtg ccgtcaccga acgcggtctt cgcctcacgc gaggccgcct
    18601 cgatcgattc gcgcaatagc gccgggtcgg cgacgcggcg catcccgcgt ccaccaccac
    18661 cggcgacagc tttgacgaac agtgggaagc gcatctcggc ggccgcctcc accagcgtgt
    18721 ccacgtcgtc ggacggttca gacgacgcga gcaccgggag cccggcagcg cgagcggcgg
    18781 cgatggcctg ggacttgtcg ccggtcaatt cgaggatctg ggccgacgga ccgacgaaca
    18841 cgatgccctc ggcctcgcag gcggctgcca ggcccgcgtt ctccgagagg aatccatacc
    18901 ccgggtacac cgcgtcggca cccgagcgtt tggctgccgc gatgatctcg gagaccgaca
    18961 gatacgcacg caccggatgc cccacgtcgc cgatctgata agcctcgaaa gccttcgcgc
    19021 ggtgcgccga gttgcgatcc tcatacggga agaccgcgac ggttgatgct cccagttcga
    19081 ctgcagcgcg aaatgcgcgg accgcgatct ctccgcggtt ggcgacgagg actttcgaga
    19141 acatggcgtt cctccgggtt gcgagtcagg gcggaatggc aaaaacgcct cgcggggccg
    19201 gcgaggcgtg gagcaggggg tgtgagctga gtctcccaca ttgaagcaca acttactaga
    19261 tgggccataa agttactcga cgcgcgcatc ccgcaagaaa agaacgccaa cttgctgcgc
    19321 aatatctctg tacatgtttc tattgtgccg atgtttctat agtgtgactt gaaatacagt
    19381 ccgacagcac ctcgaggagg actcgtgacg aacgagcaga acgccgatac ctggatcacc
    19441 gactgggagt acagcgagcg gtaccccgtc tacacgcgag ccaacgcagg cgaggtgctc
    19501 ccggacccgt cgagtcccct gaatgtgagc ctcgtctgga acaagggcct caacatcggc
    19561 tggcgtgagg gctacgtcga acacctcggt acgcacctgg catcggaact cgacgaggtg
    19621 atgcccgaaa cgctcggcaa cttcggtggg taccacttca cgaacttctc ggcgaccgaa
    19681 ctcaacggtg cccgcctacc gggcatgacc gtgccggagt ggaaccggct gtgggtcggt
    19741 gaccatccgg acctgccgga ctacgtggag aagcccggcc acgccaacgc cgagctcacc
    19801 gcacggctgg cagagaagag cgcctgggcg ctgaccaccg acgagttccc ggaagccgag
    19861 cagaccaagc gccgtgccga ccaggcccgt gcgaaccggc ccgacctgag cacactgagt
    19921 gatcagcagt tggtcgatca cgcccggtcg ttcgtccccg acctgatctt ctgctacgcc
    19981 taccacccgg tcaccaccac gctgtcgacg gtcggacctg cggtcgcggg cgcactgctg
    20041 gcctcgatcg gcgaggccga caaactcggc gacctgctga gcgggctcgg cggcgtcgac
    20101 tcggctgctc cgtcgttcgc actgtgggac atgggccgtc tggttgcgag ctccgaggag
    20161 ttgacctcgt tgttcgacaa cggactggcc accctgctcg actccgtgga cgccagcggg
    20221 tctcccgatg caaaacagtt ccggaccgac ttcgatgact tcctctacaa gtacggctcg
    20281 cgcgcaccca acgagtggga catccgttcg gacagctggg aatccaagcc cgttctggcc
    20341 ctgctcgcga tcaacgggat gcggctgagc cccgactcgt cgaaccccga gctgatccgg
    20401 gagcgcaacg agaccaagcg gatcgccctg actgcagaac tcgccgccaa gatgcccgat
    20461 gaggcgactc ggcagagctt cctcgacgca gccaagtcga tcacgcggtt catgccgtgg
    20521 cgtgaacgga ccaagactgc ctgtgtcaag gtgatgggcg agatgcgcac tgccctctac
    20581 gaattgggcc accgaatggt cgcccgcggg gtgatggaag accatcacga cgtcacgatg
    20641 ctgctcgccg acgagctcga cgccttcgca gccgaccccg agtccttcac ggagaccatc
    20701 gcgcagcggc gcgagcagta tctcgcgctc ttcgacctgg agccaccgtt cttcctgttc
    20761 gagccgcttc cgctgtcgca gtggccgaag cgcaccgagc acaaagcgga gatcgctgtt
    20821 cccggcgact cgcttgccgg tgtctccggg gcgcccgggg tcagtcgtgg tcgcgcccgg
    20881 atcttgcatg atccctacga ggccgaacac ctggaagaag gcgacatcat cattgcgccg
    20941 cagacagatc cggcctggac gcctctgttc gactttgccg gtggcgtcgt ggtcaacgtg
    21001 ggctcgacca tcacgcactc gtccatcgtc tgccgggaac tgggcatccc ctgcgccgtc
    21061 tcggtacagg acgccacagc gcgcatcccc gacggtgcga tgatcgaggt cgacggcaac
    21121 accggaacag tgacggtcct ctagtggtcg agatcggtct gaccctcccc cagctcggcg
    21181 aacacgtcga cgccgcggcc atccgggcgt tctcgacctc ggctgaggaa ctcggcttcg
    21241 cgagcctgtg ggtgcaggaa cacttgttct atccggaggc gaacgagtcg atctacggcg
    21301 gccggcacac caccagcgtc caccccgcgt atcgctcggt gctcggggcg accgagctga
    21361 tggcctttgt cgccgcctgt accgagaagg cgatgatcgg cagcagtatc ctcgtcgccg
    21421 gctaccaccg tcccgttgaa ttggcacaac gcctttcaac actggatgtc ttgtccggcg
    21481 gtcgactcgt cgcgggtctc ggagcggggt ggtcggacga ggagcacggc cagatggacg
    21541 tcgacccgcg cacgcggggc cgacggatga gcgagctcgt caacgccgtg caagcgtgct
    21601 ggggtcctga cccggtcgag ttctccggag agttcttttc catcccgcgg tcggtgatcc
    21661 gtcccaagcc actgcagcag ccgcacccac cgctgctgtc cggactacgg tcggcggccg
    21721 gattggcccg caccgcagca ttgttcgaca tctggaaccc cagcagcggt accgccgagg
    21781 ccttgcagga gcagctcgac acgatggcag gtctacgtgc cggcgacgcg gcaccggtcc
    21841 gactcttcct gcgctcatac ctgcaacgtc ccaccgatgc cgtcggctcc ggcggacacg
    21901 gcatcgaggg tgtccgcggc gacctgcgga ccgcagtcga ggcaggggcc gagcagttca
    21961 tcgtggagat aaacttctgg gacgagatgc gatccaccca ggactgggcg gatgcgccgg
    22021 cccggctggc ctcgctactc gagaccgccg aagaactctc gaccgacatt tcgaaagcga
    22081 gtgtgttgtg aaggcagcag tattcgacgg caacagcccg tcgctgacga tcgaagacat
    22141 cccccggccc gagccgcggc gcggcgagat cctgttgaag gtcaccgcct gcggtgtctg
    22201 ccacaccgat ctccacgtgc tcaagtccga ggtgaagttc ccggtcccgg cggtactcgg
    22261 tcatgaggtg tccggtgtgg tcgagcagac cggcgagggc gtggacaacg tcgccgtcgg
    22321 tgaccgcgtc gtctgcagct tcatcatgcc gtgcggcgat tgccggcatt gcgtcagcgg
    22381 caaagaggat ctctgcgaaa agttcttcgc acacaaccga ttgaacggca ctctctacga
    22441 cggagagacc cgcctgggcc gcgaagacgg cacgccgctg gccatgtact cgatgggcgg
    22501 actggccgaa tactgcgtcg tgccggcgtc tgacgccttc aaggttccgg agggagtcgg
    22561 gctcggtgag gtctcgatcc tcggttgcag ctcgttcacc gcactcggtg cgatcaacaa
    22621 cgccgatctg gtgctgggcg accggatcgc ggtgatcgca gctggtgggg tcggatcgtc
    22681 catcgtgcag ttcgcggccg cgtccggtgt ctcacagatc atcgcgatcg acatcgacga
    22741 cgagaagctc aaggccgtgg cagcgctggg tgccacccac acgatcaact cgcgggacac
    22801 cgatgtggtc gccgaggtga aggccctcac cgacggccac ggagtcgacg tcgccttcga
    22861 ggccctcggc aacaagcaca ccttcgccac cgcgctggac gttctcgacg acggcggccg
    22921 cgctgtggtg gtcggcatcg cacccgcggg cagcgtcggt gagatcgacc tggcccgtct
    22981 ggtaaggcgc aagctggaga tccacggttc gtatggcgcc aaggctcgta ccgacatgcc
    23041 cgcgctgctt cggttggtgt ccgccgggat cgtggagccc gagcgcgtca tcacccgcag
    23101 atacacgctg gatcaggtcg acgaggccta ccaggcgctt gcccgcggtg agatcatcgg
    23161 ccgcgcgatc atcgagatgg aaccatcaga gtgagtgagg caccggcgga gggcctcgtt
    23221 gccgtcgtga ccggcgcggc ctccggcatc ggccgcgccg cggtcgagat catcctggaa
    23281 cgtggtggga aagtcgtcgc attcgacacc accccggagt cgttggactg gctcgcaggg
    23341 aacccgaacg caatgccgtt cgtcggcgac gtcacctacg acgtcgacaa ccgcgccgcc
    23401 atcgagctgg ccgaagagtc gttcggccgg ctcgacgccc tgatcctgaa tgccggcgta
    23461 ccggcctccg gttccatcga gaccctcgat atggaggtct tcgaccgttc gatcaacgtc
    23521 aacctgcgcg ccgtcgcgct gggtgtacgg gagtcgattc cggctttccg acgcagtggg
    23581 ggcggctcgg tggtcatcac cgcctcggcg accgcgatgg gtggtgaacc caatcgttgg
    23641 ccctacgcgg ccgccaaggc cggcgtcgtg aatctcgcgc ggtcgttcgc gatcgacctg
    23701 gcgaacgaca agatacgggt caacaccgtg tgccctggcc cgatcagcac cgggatgacc
    23761 aagcgcatcg aggagaacac cccggagcgg tatcagtcgc tcgcgtcgat ggttcccctg
    23821 caacgatggg gcaccgcgcg tgaggtcggt gaggtcatcg ccttcctggc ctcaccgttg
    23881 gcatcgtttg tcaccggcgc atcgataccc gtcgacggcg gggcgacctg cggcagtggg
    23941 cagaccatcc cgatccctgc acccgcctga cccgcaaacg ctccacatat gcgaagacgc
    24001 accacatatt tgtggtgcgt cttcgtattt ctggagcgtt tgcgggttgg gctgggacta
    24061 gcggcgaggg tcgaccaaga ccttggcgtg ttcgctggta cccgaatcga gctccctgaa
    24121 catcgccacc agctcgccga gcccaatggt gccggtgtgc agcgacttca cgtcgatacg
    24181 tccgtcggcg atcagcctca tggtggcggc gaagtcctcg tgggagtacg cgagcgatcc
    24241 gatgacggtc agttcgcgac tctgccaatc cccataactc acagacgaat cggtgcccgg
    24301 atagccgagc aacgcgagcg tcccgccgcg ccgcaccagt tccgccgagg gctgcagcag
    24361 agctgcgacc ccggtgcatt cgaacaacac gtccgcgccc aacccgttcg tggcgtcggc
    24421 aagcatcccg ggcaggtcgg ccggctcgac cacatcggtg aagccgaggg cggtggccgc
    24481 ggcccggcgc ggggccgacg gttcgctgat gatgagcctg cccgccccac cggtgcgtgc
    24541 gtgttgtgcg gtgagcaagc cgatcggtcc tgcgccttgg acgacgacgg tcgacccgaa
    24601 ccggagctga gcccgccgga ccgcgtgaaa cgtcaccgtc gccggttcca tcagcgccgc
    24661 ttcttcgtcg gacagctcgt cgagcacggg aatcgctcgc cgggcagaca ctttcagctt
    24721 ggtcgcgaaa ccaccatggg tgggcgcatc gtcggtgatg ccgttggcct ccgcgaacgc
    24781 cagatcacag ttggaggcgt gacctgcgcg gcactgggca cagataccgc acgcagggcc
    24841 gacaccggca accacgcgtt gcccgacctc caccgtcgtg acgtcggcgc cgaccgcgct
    24901 gacggtgccc atccattcat gtccgaacac cgcaggtggc agggcggccg acgcgtaccc
    24961 gtgggtgtcg gtggcacaga tgccgcagaa tccgatgtcg acgaccacac cgtcaggcgc
    25021 cggcccgggc tcggcctcga caacggtctc cgcgacctcg ggcgcgatca tgtgaacgaa
    25081 cttgctctcc actgcagatg tcatgcgtgt catcactttc cggtcatgcg ctcgacgatg
    25141 ggcgcgaatt gttcgtaagc tcggtcgccg atggtgaagt aggagaagcc gaactcttcc
    25201 cgccgctgtt cgagctgctc gcagatgtca tcgaccgacc cgacgagcgc gtggggaaaa
    25261 gctcgcagct cgtcgcgaga gaatcccgtg cgctcgatca gcgcctcctc ggttacgtcg
    25321 gtctgccctt cgatggccac gaaataggcg cccgtctcga gttcgatgcc gtccacccgg
    25381 tctcccgcgc cgtcgcgcac ccagcccagc ttcttgtgtg tctcttcgac ggtcgaggtg
    25441 agcacgctgt ccgaacccag cacacccgaa cggttgttga aattgatact gacgatgtcg
    25501 gcggttctgc ctgccaacgt cagcactcgc cgcgcgccgc cgccgatcat gatcggcggc
    25561 gtgatctcgg gcaccggcaa cggcgcgaag ctgtgcgcct tgacgaacgt gccgtcgacc
    25621 ttgatctcgt ccccggccag gtactgggtg atcagctcga cggtttcttc gagtcggtcc
    25681 acccgcagac ctgccgacgg gaagtcgatg cccatcgcgt cgtattcaga gccgagccag
    25741 cctgcgccga gcccgatctc gattcggtct ggtgcgaaca tcgcaagagt cgcagcctct
    25801 ttcgccagca ccaccggttc gtggtagctg gtgcagaaca tgcggcaacc taccttcaac
    25861 gtgtcggtga cctctgcggc gacggccatg ctcgtgatcg gtgccatcgt caccggacga
    25921 tgcccggtcg ggtcgagcgc tgggcccggc ccgatgtagt gatcggacac gtgcagggct
    25981 gaatagccca tgtcttcgac cttgtgcgcg acgtcgcgcc attcctgtcc ggtgtttgcc
    26041 cgatagacct gggcagcgaa cctgaagggt ttcttagtca tgactacagt ttctcattca
    26101 tcgtcgattt tcacgaggcc gggctcggtg cgagtgccgc cgccttcagc acctcacgcg
    26161 cggcccggcc gaggtcggca gtccatccac gcgggtcggt gacggaccgg gcggacggtg
    26221 cctccacact gaccgccgca gtcgccggca accggcgtag cagttcgacc aggggcaatg
    26281 cccccgttcc tggagcgagg cgatcggttc gggcctccgt gatcgccgcg ttgtgatccg
    26341 cggcgggtgc gtccgtgggc gcatcacaga gctggcagta cggcatcagg tcgggggcga
    26401 tggcatcgag ctcactccac tgcgaacccg cacgagagaa atgcagtgcg tcgacgagca
    26461 ctccggcatc cgaaccgcgc gcgtcgagaa cgaacttcgc tgcagccgtc atgtcgcgaa
    26521 ccgacgagaa caccatgggc tccaaacagg atctgagtcc gtactcgccg gacaactccg
    26581 ccaactcggc aaagttgtct gtggcccgcg aatagtcgtc atcgagaacg gtcaccagga
    26641 gatggctcgc gtcgagttcg gcgcccgcct cgagcaccgc cgaccaatct gcccgcgagc
    26701 tccccggatg cagtttgacc acctcgacat cgagcacccg catcccgttg tcggacaggg
    26761 cggtcttggt ctcgcgcagg agcgccgacc ccgcacggag ctgaaaccca cggtcctgcg
    26821 ccgtctgcgc cacccgtagg ccgacagcgt cgaaaccgcc gaatgcggcg ttgtcgatga
    26881 actgcggtgg cggcacgccg atcgccgaca ggtgcgagag ggacaatatg cgttgcgctg
    26941 gagtgacttc cacccttact ccgatctggt tgccgcctga gatgacactg cccgggcggt
    27001 cgtgctcggg cccgggcagt gtcactcatg gggtgttgat tcctacttga gccacagggc
    27061 cttgaactga tcttggtagt ccgcgacacc tacccagtag cccgtgtcgg cgtcgatgac
    27121 ggccgagtcg atgttctccg cattgagcag ctgtgtcggg aggaacgccg cgtccgccgg
    27181 agcgaggtcg tccccattga actggcgggc cagcatgtcg atgacacgcc atccgagaat
    27241 ctggaccggg aatccgaccc acacgctgtt gtcgccgtcc ttgagcgatt tcaggttgtc
    27301 gggagtgggg gtctgacccg cgaaggtcac ctgatcctgc agtcccgcgc cgcgcagggc
    27361 ggcgtcgacg ccgagcacga ggtctccgaa ggagaacacc gcgtagttga tgttcggatc
    27421 acgctgcagc gtactgacga cgctctgcgg ggtcttggtg ccgaggtcgg cgacctgctg
    27481 gttgacgagt tcgaccttgc agtcggggca ctgagccttc atctgcgcgg tgaacgcgtc
    27541 ggtgaagatg ttcaggatcg ggtagtcggt gatggtgaag atggcgacgt tggccttgcc
    27601 ttcggactcg gcgaccacct ggctggcgac catcttgccc cactcctgca cctgcccgtc
    27661 tccgtccagc gacgtcgaga tgacgcctgg gatcggttca ccggacacac tgtcggcgat
    27721 caccgggatg ccggccgcct tggcggattc gatctgcttg gcgaccatcg acaggggggt
    27781 accggacatg tggatggcat cgggcttgag cgcgatcgcc tggtcgattg ccttgcctgc
    27841 ggcctcggca tcggtgccca tggtgatgcg ctggtaccgc caacccagca gatcggccgc
    27901 ctgctggatg gcgtcgttct tggcactgga aataggctgc ggcgtctcga tgctgatgac
    27961 gtacttgccg gcgacgggag ccttgctcag cggggtgtcg aggacgagac cggcaggcgc
    28021 cgcttcgtac tggtctgcca ctgcctgcgc gccggagacg tcggccgcct ggccgctgcc
    28081 gccgtcgtcg gagctgctac acgctgtcgc gaacatactc gcggcgacaa cggcgacgaa
    28141 cgcctttgtc catctggtgg tcttcactgg gattcctctc gggggtggct tgagcgccgt
    28201 ggactgaacg aaaattgttg tcgggaaaac tatttgagcc agagcttctc gaactgctcc
    28261 tggtagtcgg caacaccgat gtagaaaccg gtgtcgggat cgagtactgc ggagtcgatg
    28321 ttgttcttgt tcaacaactg cgtcggcagg aaggcgtcat cggcgggttg cagggagtcg
    28381 ccgttgaact gacgcgcgag catgtcgaga acacgccagc cgatgatctg gatcgggaat
    28441 ccgacccaca cgctgtcgtc accgtctttg agcgacttca ggttctcggg cgacgggctc
    28501 tgtccggcga accggacctg gtcctgtagg cctgctcccc gcaacgcagc gtcgacaccg
    28561 aggacgaggt cgccgaacga gaagaccgcc cagttgatgg aggggtcgcg ctgcagcgtg
    28621 ctgaccacac tctgcggggt cttggtaccg aggtcggtga cctgctgatt gaccatctgg
    28681 gtcttgcacc cagggcacag ggtctcgagc tgcgccttga acgcatcggt gaagatgttc
    28741 aggatcgagt aatcggtgat cgtgaagatg gcgatgttcg cgttgccgtc actgtccgcg
    28801 acgacctgac tcgccaccat cttgccccac tcctgcacct gggcgatgcc atcgatggag
    28861 gtggagatga cacccgggac cggctcgtcg cccacactgt cggcgatgac aggaatgcct
    28921 gccgccttgg cggattcgat ctgcttgctc agcatcgcga gcggggtacc tgcgatgtgg
    28981 atggcgtccg gcttcagggc gatggcctgg tccatggcct tcggtgcggc ctcggcatcg
    29041 gtgtccatca ggatgcgctg atagcgccag cccagcacgt ccgccgcctg cgcgatggcg
    29101 tcgtccttcg cgaccgcgat cggctgaggc gtctcgatac tgat
//
