LOCUS       NZ_QJSP01000009        23278 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Williamsia limnetica strain DSM 45521 Ga0244495_109, whole genome
            shotgun sequence.
ACCESSION   NZ_QJSP01000009
VERSION     NZ_QJSP01000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Williamsia limnetica
  ORGANISM  Williamsia limnetica
            Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
            Nocardiaceae; Williamsia.
REFERENCE   1  (bases 1 to 311394)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 311394)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JUN-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Expected Final Version            :: No
            Genome Coverage                   :: 169.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003217475.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 01:29:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,026
            CDSs (total)                      :: 5,970
            Genes (coding)                    :: 5,910
            CDSs (with protein)               :: 5,910
            Genes (RNA)                       :: 56
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3 (5S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 60
            CDSs (without protein)            :: 60
            Pseudo Genes (ambiguous residues) :: 0 of 60
            Pseudo Genes (frameshifted)       :: 17 of 60
            Pseudo Genes (incomplete)         :: 43 of 60
            Pseudo Genes (internal stop)      :: 7 of 60
            Pseudo Genes (multiple problems)  :: 7 of 60
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:55:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 128720
            Orig. end                         :: 151998
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QJSP01000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23278
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="2"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23278
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23278
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13278]"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13278
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    450..464
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.64"
                     /tool="antismash"
     misc_feature    complement(550..564)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     misc_feature    complement(730..743)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.09"
                     /tool="antismash"
     gene            complement(2337..3440)
                     /locus_tag="DFR67_RS16185"
                     /old_locus_tag="DFR67_109117"
     CDS             complement(2337..3440)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017856.4"
                     /locus_tag="DFR67_RS16185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109117"
                     /product="FUSC family protein"
                     /protein_id="WP_158539971.1"
                     /transl_table=11
                     /translation="MTSRWARRATVFLAPATWLQRAATQRGMERAALIQAIKASVAALI
                     AWVLAAEVFDFSQPFLAPWSAVFIVAATVYRSVRSAAQQLAASFIAVILASAATEFIPW
                     DLAALFIAVLLGLLVGQWRYFGDSGTWIGITALLILTSASVEESALIDRLIETAIGAAI
                     GIAVNATIAPPVHQLDAADAIRRVADDLADVLDHMGTAALSDDRQSFDSGMRARAAVVL
                     VRDAERAVALDRESRRLNPRVRAGGIGSSDWDAKLSALRHAWSHVEELGKTLQATRQES
                     GPFEKQTRRCLAEMFGHLAELVLKSSDDAASQTDVEQAADAARQSLHAVEHILEATDSV
                     TISSVARLVTITAPARHVIRELSSRSA"
     gene            3703..3882
                     /locus_tag="DFR67_RS16190"
                     /old_locus_tag="DFR67_109118"
     CDS             3703..3882
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DFR67_RS16190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DFR67_109118"
                     /product="hypothetical protein"
                     /protein_id="WP_110470534.1"
                     /transl_table=11
                     /translation="MEIVAFVVIAVVVIAVVFLLPRTKKTQQPKDNQPHLQHEHRTGRA
                     RALRDRLRSKTPPH"
     gene            complement(3903..4688)
                     /locus_tag="DFR67_RS16195"
                     /old_locus_tag="DFR67_109119"
     CDS             complement(3903..4688)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014928032.1"
                     /locus_tag="DFR67_RS16195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109119"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_110470535.1"
                     /transl_table=11
                     /translation="MCDDNTELQGCDLQVGYRGGSVINDLNVQITKGTLTALVGPNGSG
                     KSTLLMTLARVLLPRRGEVRLHGTPISAQRSTAVARALAVLPQTAIAPTGLRVRELVEQ
                     GRFPRLGTFARLSRTDDEAMHHAMALAGVESLADRRLDSLSGGERQRAWIAMVLAQDTD
                     ILLLDEPTTYLDIRHQIDLMELLVDLVRVHGKTVVVVLHDLNQAARYCDRIVALRGGEI
                     IADGRPATVVTADLLRSVFDVRARITADPVAGRPMFTAE"
     gene            complement(4669..5664)
                     /locus_tag="DFR67_RS16200"
                     /old_locus_tag="DFR67_109120"
     CDS             complement(4669..5664)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013219.4"
                     /locus_tag="DFR67_RS16200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109120"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_110470536.1"
                     /transl_table=11
                     /translation="MRRSVVLLIGGATILCGLIVAHLLVGRSELGMGDTLRALSGSSAV
                     RSHETIVFRYRLPRVLVGIGAGALLALSGALLQAVMRNPLAEPGTAGVGSGAALGVVVS
                     LILFPGNDFATAAALIGAVACGAMLFLVGRRSLAVAGILIGAVLGAVTSLLLVVDGKPM
                     GVVLRWLIGSLNARTQADWDSLWPWVLALTAAGLFLAPAANVLSLGDIAATGLGARPSH
                     TRFALLAIAVIAAATAIAAAGAVAFVGLMAPHAARALVGADHRDLIPVSVVFGAICLSG
                     ADLVAFSITLDLPGAGPAVSGLPVGALTALLGAPYLIWLVRREHHVRRQH"
     gene            complement(5661..6683)
                     /locus_tag="DFR67_RS16205"
                     /old_locus_tag="DFR67_109121"
     CDS             complement(5661..6683)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013219.4"
                     /locus_tag="DFR67_RS16205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109121"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_110470537.1"
                     /transl_table=11
                     /translation="MITIINSRERTRYGSRTPTLVVAGLLAAGAVLAASLCLGDPTLTP
                     AQALSALLDPSAPLHPNVFDARLPRTLLGLLGGAALALAGILMQDAMQNRIAGPEILGV
                     SSGAAVVLTAVTVCALPVPLAGLPYVALGGALATGTVVIAAVGRTRDSTQVLLIGSAAS
                     AMASGLVIALVSLGTEGNIPLLFRYLLGSLSDRGWPHLSVVMPWLMVAIPVAYLLRHRV
                     AALALGDDVAAGLGINVVRSRVLALVCAAVLAAVVASVCGPVAYVALLAPHLSRWALQT
                     TSSRRVFWLTPIVGATLLAAADLVSRTVLYPIEIPVGITTTLIGVPALLYSLHRQESSR
                     "
     misc_feature    6666..6681
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.5"
                     /tool="antismash"
     misc_feature    complement(6666..6684)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.13"
                     /tool="antismash"
     misc_feature    complement(6668..6681)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 19.04"
                     /tool="antismash"
     misc_feature    complement(6668..6682)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.52"
                     /tool="antismash"
     misc_feature    6669..6682
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 18.35"
                     /tool="antismash"
     misc_feature    complement(6669..6684)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: strong, score: 27.0"
                     /tool="antismash"
     misc_feature    6674..6690
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.21"
                     /tool="antismash"
     gene            6716..7651
                     /locus_tag="DFR67_RS16210"
                     /old_locus_tag="DFR67_109122"
     CDS             6716..7651
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013648.4"
                     /locus_tag="DFR67_RS16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109122"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_110470538.1"
                     /transl_table=11
                     /translation="MRKFTTSSRFQRTAVAVSTLAVLTTTACAGGDSDSGTGAISVTDA
                     TGATVSLDGPVDRIACLTMICVDALKEVGITPVAYREDLATDDRFFGPDAGMRKITGGF
                     GEENVEDIALSEPDLVIGLAGVQDGLRVAVEESAPLYLVDPASWQQSVDFLRTVGQVTG
                     KESEATAAADAFTEKVDAAKQSRSDLTTLSMYGEPGSLGVDSVGTPVGSLLAEVSRYPW
                     ASGTDAFATVSVEQIASVNPDVIFAQAFSAGSDSEPLSVRLAANPVWPTISAAENDRVV
                     EVEADVWATGRGTVSLGIVLDVVMAELGPA"
     misc_feature    7656..7671
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.87"
                     /tool="antismash"
     misc_feature    7656..7674
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.44"
                     /tool="antismash"
     misc_feature    complement(7658..7671)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.33"
                     /tool="antismash"
     misc_feature    complement(7658..7672)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 26.44"
                     /tool="antismash"
     misc_feature    7659..7672
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.48"
                     /tool="antismash"
     misc_feature    complement(7659..7674)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 25.69"
                     /tool="antismash"
     misc_feature    complement(7743..7757)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.0"
                     /tool="antismash"
     misc_feature    7747..7762
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.08"
                     /tool="antismash"
     gene            7757..7882
                     /gene="amiA"
                     /locus_tag="DFR67_RS31145"
                     /old_locus_tag="DFR67_109123"
     CDS             7757..7882
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: protein motif:HMM:NF040714.1"
                     /locus_tag="DFR67_RS31145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109123"
                     /product="streptamidine family RiPP"
                     /protein_id="WP_245937989.1"
                     /transl_table=11
                     /translation="MIDNEFFRPIQAPVTLATHSAGHSNALVENPFDDVQDTDAE"
     gene            7972..8667
                     /locus_tag="DFR67_RS30540"
                     /old_locus_tag="DFR67_109124"
     CDS             7972..8667
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DFR67_RS30540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DFR67_109124"
                     /product="hypothetical protein"
                     /protein_id="WP_158539972.1"
                     /transl_table=11
                     /translation="MHLSPNTSIYRARNGYVLRTADDRHYELTLPDREVDELLDVLGGN
                     GVPESTDVSAVVAALVDSGDVVVRATLPTVAVHGSGRIAEKVVNMLSSSIIRSTDQADV
                     VCHLSDDEVDPEAIGQVDLACYRDGISQVITPRAVAPGDVIGRRRACNLHRDRIPSQYR
                     PVGGRRLDSPEHPVSDRAAELIAHLIVDEIGRRGVAADERSHYLLTVVDLRTLTSVRRP
                     VLPIPSAPQ"
     gene            8664..10004
                     /locus_tag="DFR67_RS16220"
                     /old_locus_tag="DFR67_109125"
     CDS             8664..10004
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014215.4"
                     /locus_tag="DFR67_RS16220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109125"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_158539973.1"
                     /transl_table=11
                     /translation="MISELVRVGDTALRTLVALPATRPHAVLVLRTPYDADQHVDEARQ
                     WTLRGVAMVVQDVRGRYGSSGRFRPYENEGSDGLATVEWVRRQCWGRAPIILYGTSYAA
                     HCAVETAIAAASSDMDVVDGVSVAVPALGLGESARNVDGSFQLESRVGWWLEHGEGQRS
                     PGTAIPDGALSTLPVVDIGARVNPPIEAWHRVLRAARRDAERATSTALLRCPLLAIGGT
                     ADWFAQDTIDLWSSWGGPSALVIGPWDHGLRNSGRARHMQSWIADVVAGEAPSGAQVHG
                     LPAGIRRYAQWPSSETRIHLKGGHFRSDPSTPFPSLAFGVDIGRPARRPDCLLVDFEHR
                     ASVVVGSPTVRIVSSHGHHQWSAVLAVRRRDGRLEQLAHGTSPRPDIRLTPVSTHLEPG
                     ETMAVIISAHSFPRHPRDLQVGDDPLTGTTMRTTDREVHGVFVELPA"
     gene            10001..11362
                     /locus_tag="DFR67_RS16225"
                     /old_locus_tag="DFR67_109126"
     CDS             10001..11362
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="DFR67_RS16225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109126"
                     /product="YcaO-like family protein"
                     /protein_id="WP_211325083.1"
                     /sec_met_domain="YcaO (E-value: 2.6e-53, bitscore: 175.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGPAILTAEDLVDPYAGIIRALHPVERLDGMPDRYVGLTAEIAD
                     TRAHGNWPSDLVSLGTTFADDAGARIAAIGEAVERYCGNHVPVGLVRASARELQASGVR
                     HLGPAQLNFFAPWQLQTPGFPFSQFTDDTSVVWAKGSGDDGLPTLVPASFVYLNWRTGG
                     RQREPWLHHLNYAGIATGAGLEDAATRGLLELVERDSLSLWWHLNLPARGIALESVPGL
                     IDDLGDTRLRCHLLELPAFFGVPVVAAVIHDPELGIVAGGFSAKLDPAATARKAVLEAL
                     HSWVFTRGLTDADGWVFASMEAGVLSRGLYLDHRADRSYLTGAGARSEHIRDLGAQAQV
                     WLDPRTQQALLSRFTEPASTIGVGEMPTGDIGTLHARLREAGHHVVVCDITTPDVALTP
                     LRVARVCAGGLIPNAPAAFPYFGLARWREVAQAAAVAGDPDDPESLLLIPPPSL"
     gene            11359..12585
                     /locus_tag="DFR67_RS16230"
                     /old_locus_tag="DFR67_109127"
     CDS             11359..12585
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="DFR67_RS16230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109127"
                     /product="MFS transporter"
                     /protein_id="WP_110470541.1"
                     /transl_table=11
                     /translation="MNPFRTFVLARSICWAGNAVTLVALPLFVYQQGGSALLTGVAFAV
                     ESMPYLLFGLFAGATADRFDRKRILVVSQILSAVILSTIPLAAVTGIASIAHVLVVGFA
                     VSTLFVYYDAATFGVVPALVGRDGIADATALLVTTGTVIGIAGPLLGGIAASALSPAGA
                     IAIDAGCYVVAALITATVAVPASTGAADADRRVWQQISEGLQYIWRQPVIRMLTLVGIG
                     VSMANGVVVGLMVVVGVRRLGLDDGDARLGALYAATALGAFLISLVSAHIQRRMGTGKI
                     TLVGIGVAASAMLVWAHTTSFAASLLILVAYQAANTMVVVNGIVVRQSITPDHLQSRVN
                     TTARMIAMGGTPFGATLGGAVAEVAGAGVALSIGAAALVLAVAGGLHAGVGRLPLLAEL
                     SAGAHGKGE"
     gene            complement(12535..13278)
                     /locus_tag="DFR67_RS16235"
                     /old_locus_tag="DFR67_109128"
     CDS             complement(12535..13278)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03605.1"
                     /locus_tag="DFR67_RS16235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109128"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_110470542.1"
                     /sec_met_domain="PF00881 (E-value: 1.5e-16, bitscore: 55.0,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTQFSSRIDRVQRIHQALSDNAPDPSMSTALSDSTGSVSLRAPG
                     DEPTLPLGRALLERRSRYVFGSLRHLELSTLLRWALGPQRTVTTGERTAHTLDIHPSAG
                     GLNSMTVHVVALEPIDDIASAIYTFDPARHRLIQRRTGDIRTAFGECLVQAEFAQRASV
                     CLVLAGEMTATLVKYSERHYRTVHVDAGVAAAHLYLVGEALELSCCAISGFYDDRVADV
                     LSLDDTQIPLLAFAVGARRELGEQR"
     misc_feature    complement(13234..13251)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     misc_feature    13290..13305
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    complement(13293..13308)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            13511..15001
                     /gene="styD"
                     /locus_tag="DFR67_RS16240"
                     /old_locus_tag="DFR67_109129"
     CDS             13511..15001
                     /EC_number="1.2.1.39"
                     /GO_function="GO:0008957 - phenylacetaldehyde dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042207 - styrene catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="styD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016882275.1"
                     /locus_tag="DFR67_RS16240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109129"
                     /product="phenylacetaldehyde dehydrogenase StyD"
                     /protein_id="WP_110470543.1"
                     /sec_met_domain="Aldedh (E-value: 1.6e-177, bitscore:
                     584.8, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVQDSLIAGGGLPDETPTELFVAGTWRQSSDGSSFTDLNPATE
                     EVLAEVSAATASDVDEAVRAARAQLGGEWGSMPGVMRGKILNKVADLIERDADALATLE
                     SLDIGKPLGQPAMLDIPNAAATFRHFAGWADKITGQTIPTAGYFGQQTHSYTVREPVGV
                     IGAIVPWNTPLMIAAWKLAPALAAGNTVVVKPSEDAPLSILHLAKLLQESGIPDGVVSV
                     VPGLGDVAGDALVRHPDVDKISFTGSPRVGRLIAKIAADTFKRTTLELGGKSPQIILAD
                     ADVEAAINGTAMGLFFNQGEVCAAGTRVLVHRSLYSQVVDGLAAAASAQVLGDPREAAT
                     TMGALVNAKQRDSVLAYIEAGKRDGARVVAGGHRHGDKGFFVQPTIFADASNDMTIARE
                     EIFGPVGTVIPFDDVDEAIRIANDTEYGLAASIWTRDVSYAHRLAAQVRAGAVWVNGWA
                     AIDPALPWGGMKSSGTGRELGWAGIEANTEEKVVTVVL"
     gene            15030..16142
                     /locus_tag="DFR67_RS16245"
                     /old_locus_tag="DFR67_109130"
     CDS             15030..16142
                     /EC_number="1.1.99.36"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (22-293). E-value: 2.1e-11.
                     Score: 35.4. Matches aSDomain:
                     nrpspksdomains_DFR67_RS16245_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007238300.1"
                     /locus_tag="DFR67_RS16245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109130"
                     /product="NDMA-dependent alcohol dehydrogenase"
                     /protein_id="WP_110470544.1"
                     /sec_met_domain="ADH_N (E-value: 1.5e-25, bitscore: 83.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.8e-18, bitscore:
                     59.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTQAAVLWEPGQDWQIEELILDDPKYGEVKVELAASGLCHSDEH
                     VRDGSVPVGLLPFIGGHEGAGVVTQIGPGVTSLEVGDHVSLAFIPACGRCRECANGQSS
                     ICDLGAHLLEGYQVSDGTARHHVRGKDAGIQCLLGTFAPHTVVNEASCVKITKDIPLDK
                     AALVGCGVTTGWGSSVYAAGVGAGETVVILGMGGIGCGAVQGAALAGARHVVVVDPSSF
                     KREQAKIFGATHTAADIDEALILVNELTWGHLADKVLITVDVARGELIAPAMSLVAKGG
                     VCVQVSVGNVADIDTKLSLFDLTAMRKTLKGAWFGNANIRFDIPHLLRLYMEGQLKLDE
                     MITREYTLDQVNDGYEAMRRAENVRGLIRY"
     aSDomain        15096..15908
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS16245_PKS_ER.1"
                     /evalue="2.10E-11"
                     /label="DFR67_RS16245_PKS_ER.1"
                     /locus_tag="DFR67_RS16245"
                     /protein_end="293"
                     /protein_start="22"
                     /score="35.4"
                     /tool="antismash"
                     /translation="DDPKYGEVKVELAASGLCHSDEHVRDGSVPVGLLPFIGGHEGAGV
                     VTQIGPGVTSLEVGDHVSLAFIPACGRCRECANGQSSICDLGAHLLEGYQVSDGTARHH
                     VRGKDAGIQCLLGTFAPHTVVNEASCVKITKDIPLDKAALVGCGVTTGWGSSVYAAGVG
                     AGETVVILGMGGIGCGAVQGAALAGARHVVVVDPSSFKREQAKIFGATHTAADIDEALI
                     LVNELTWGHLADKVLITVDVARGELIAPAMSLVAKGGVCVQVSVGNVAD"
     gene            complement(16216..17181)
                     /locus_tag="DFR67_RS16250"
                     /old_locus_tag="DFR67_109131"
     CDS             complement(16216..17181)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014361420.1"
                     /locus_tag="DFR67_RS16250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109131"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_211325084.1"
                     /transl_table=11
                     /translation="MPQSESIDQVTPDGITTAPPHDRVGFDEWREAISSAFVPLDASPD
                     HRPGDFSGALSSITVGDLQLAEVLGDCSHVRRSVATIRRADPGVIKVGLQLHGHSTVQQ
                     NGRHATLAPGDLAIYDTSVEYGLHLTDSFDMLVAVIPRQALRVADRELTDATARTITTT
                     TGAGALLGPLLLSLRSNHQGSSAATPLIEDAVADIVSAVVRSSAPVDALGSGQTVLLSA
                     RAYIEAHLGDPTLCPTAVASHHHVSVRYLQKLFAYDGLSVAGFIRQRRLERCRRDLADR
                     TQSHRSVGSICATNGLVDASHFSRLFKQTYGVSPRHYREA"
     gene            complement(17190..18503)
                     /gene="paaK"
                     /locus_tag="DFR67_RS16255"
                     /old_locus_tag="DFR67_109132"
     CDS             complement(17190..18503)
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (75-340). E-value: 1.5e-22.
                     Score: 71.6. Matches aSDomain:
                     nrpspksdomains_DFR67_RS16255_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014361421.1"
                     /locus_tag="DFR67_RS16255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109132"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_110470545.1"
                     /sec_met_domain="AMP-binding (E-value: 1.2e-26, bitscore:
                     87.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVLSNTPTAPGDDIEFATRDRISTLQLQRLQWSLKHAYDNVPH
                     YRTAFDAAGVHPTDLKDLSDLAGFPFTAKADLRENYPFGMLAVPQDKVSRIHASSGTTG
                     RPTVVGYTSNDISNWADLVARSLRAAGVRPADKVHVAYGYGLFTGGLGAHYGAERLGCT
                     VIPMSGGMTDRQIQLIEDFEPDAIMVTPSYMLTIVDAMIKKGIDPATTSLRTGVFGAEP
                     WTEEMRKEIETSLNMDAVDIYGLSEVMGPGVAMECVETKDGLHIWEDHFYPEIIDPETG
                     AVLPDGEEGELVFTSLSKEAMPIIRYRTKDLTRLLPGTARTMRRMKKVTGRTDDMIILR
                     GVNLFPTQIEELILTVPALSPQFQCVLERAGRMDNLIVKVEARPGVLSDQHAAASMALQ
                     TLIKNRIGVTVTVDIVGPEGIERSVGKAKRLIDKRPKI"
     CDS_motif       complement(17454..17516)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DFR67_RS16255_0001"
                     /evalue="1.20E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="DFR67_RS16255"
                     /protein_end="350"
                     /protein_start="329"
                     /score="11.7"
                     /tool="antismash"
                     /translation="TGRTDDMIILRGVNLFPTQIE"
     aSDomain        complement(17484..18278)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS16255_AMP-binding.1"
                     /evalue="1.50E-22"
                     /label="DFR67_RS16255_AMP-binding.1"
                     /locus_tag="DFR67_RS16255"
                     /protein_end="340"
                     /protein_start="75"
                     /score="71.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DLRENYPFGMLAVPQDKVSRIHASSGTTGRPTVVGYTSNDISNWA
                     DLVARSLRAAGVRPADKVHVAYGYGLFTGGLGAHYGAERLGCTVIPMSGGMTDRQIQLI
                     EDFEPDAIMVTPSYMLTIVDAMIKKGIDPATTSLRTGVFGAEPWTEEMRKEIETSLNMD
                     AVDIYGLSEVMGPGVAMECVETKDGLHIWEDHFYPEIIDPETGAVLPDGEEGELVFTSL
                     SKEAMPIIRYRTKDLTRLLPGTARTMRRMKKVTGRTDDMIILR"
     gene            complement(18533..19633)
                     /gene="paaE"
                     /locus_tag="DFR67_RS16260"
                     /old_locus_tag="DFR67_109133"
     CDS             complement(18533..19633)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaE"
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006369759.1"
                     /locus_tag="DFR67_RS16260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109133"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaE"
                     /protein_id="WP_110470546.1"
                     /transl_table=11
                     /translation="MTATAEPAVSPTSKRTKPFHTLTVADVEPLCDDAVAVRFDVPDAL
                     ADEFVFGAGQSLTLSRTVDGVEHRRSYSICAPVGSPPRVGVREVTDGLFSSWLVHEVQP
                     GDRVDVQGPTGNFVADPDAGGRHVLIAAGSGITPMLSIAGSMLANPEAEVTLLYGNRRS
                     RSVMFSEDIADLKDEYGSRFDVIHVLSREPREVELFSGRLDAQRLRAILDTLVPIADID
                     DFWLCGPFGMVNDAQDVLADLGVPKSAVHHELFYVDDVPPPLEKHREPGITGPSSEVTI
                     TLDGRAVSGTLPRDESILDAGEQLRSDLPFACKGGVCGTCRAKVTGGEVDMRRNYALED
                     SEVDSGFVLTCQTYPVSDTVTVDFDA"
     gene            complement(19635..20144)
                     /gene="paaD"
                     /locus_tag="DFR67_RS16265"
                     /old_locus_tag="DFR67_109134"
     CDS             complement(19635..20144)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009475633.1"
                     /locus_tag="DFR67_RS16265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109134"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaD"
                     /protein_id="WP_110470547.1"
                     /transl_table=11
                     /translation="MTTAHMTSPRTIAASVLDPEMPLLTLDDLGVLRDVEVTDDGGVVV
                     TITPTYSGCPAMATMRDDIEHKLLDHGYSRVEIVTRLSPAWSSDWISDEGRRKLSDTGY
                     SLPGPAPTRSSGPVPLTLTATPRVIDCPRCGSRNTHLKSEFGATLCKAQYHCLDCLEPF
                     DHVKEI"
     gene            complement(20146..21063)
                     /gene="paaC"
                     /locus_tag="DFR67_RS16270"
                     /old_locus_tag="DFR67_109135"
     CDS             complement(20146..21063)
                     /EC_number="1.14.13.149"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005250777.1"
                     /locus_tag="DFR67_RS16270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109135"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaC"
                     /protein_id="WP_110470548.1"
                     /transl_table=11
                     /translation="MIDHDNAYEGLVDEDSHGQWAFGTSFDDPLAGVDTTVPDDVDLTA
                     LAAYCLMLGDDALISSQRLAQWSTRAPELEEEVALANVGLDLLGQARLLLARAAAADPA
                     VVPYISDTSPVPSEDALAFFRDESDFRNVRLCEIGNGDFAKTQVRLLLFTTWRLAVFDR
                     LRTSRDPVLAAVASKGVKELTYHRDYAARWVVTLGCGTDESKRRITDALERVFPYIDEL
                     FLPTDDEIALAAVSVAVDPRDAREEFDSVIAHVLHAAELEAPGNRNVGTIGGRGGRRGI
                     HTEAMGHLIAELQSVARAHPEGVW"
     gene            complement(21075..21437)
                     /gene="paaB"
                     /locus_tag="DFR67_RS16275"
                     /old_locus_tag="DFR67_109136"
     CDS             complement(21075..21437)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019662811.1"
                     /locus_tag="DFR67_RS16275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109136"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaB"
                     /protein_id="WP_110470549.1"
                     /transl_table=11
                     /translation="MSEQSAEGGHGAVPIEDVPVEPKKSAVKADWPLFEVFLRGKRGLN
                     HVHVGSLHAADNEMALRHARDVYTRRNEGVSIWVVASNSIIASSPSERDPFFAPSGDKV
                     YRHPTFYDIPDDVPHM"
     gene            complement(21434..22396)
                     /gene="paaA"
                     /locus_tag="DFR67_RS16280"
                     /old_locus_tag="DFR67_109137"
     CDS             complement(21434..22396)
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="paaA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008712389.1"
                     /locus_tag="DFR67_RS16280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109137"
                     /product="1,2-phenylacetyl-CoA epoxidase subunit PaaA"
                     /protein_id="WP_110470550.1"
                     /transl_table=11
                     /translation="MNTSHDISGAPEEALLQEFDHTIDAGQRVEPRDWMPDGYRKTLIR
                     QIAQHAHSEIIGMQPEGNWLTRAPSLRRKAILMAKVQDEAGHGLYLYSAAETLGADRSD
                     LTEKLIEGKQKYSSIFNYPTLTYADVGTIGWLVDGAAICNQVPLCRSSFGPYARAMIRV
                     CKEESFHQRQGFELLTKMMRGTDEQRAMVQESVNRWWWPALMMFGPPDDESPNTEQSMK
                     WGIKRHTNDELRQRFVDMSIPQAKALGVTFPDPDLKWNANRKSHDFGEPDWSEFLAVVK
                     GNGTSNIERIANRRAAHEDGAWVREAAMAFAARDKKAAS"
     misc_feature    complement(22454..22468)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.1"
                     /tool="antismash"
     misc_feature    22458..22472
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.36"
                     /tool="antismash"
     gene            complement(22479..23258)
                     /locus_tag="DFR67_RS16285"
                     /old_locus_tag="DFR67_109138"
     CDS             complement(22479..23258)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (6-250). E-value: 5.8e-50. Score:
                     161.8. Matches aSDomain:
                     nrpspksdomains_DFR67_RS16285_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006369753.1"
                     /locus_tag="DFR67_RS16285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DFR67_109138"
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_110470551.1"
                     /transl_table=11
                     /translation="MTAVLNTTDGLATITLARPAAHNALDVATKLALLDAVTTAAKDPS
                     VRAVLITAEGKNFCVGQDLSEHVSALEADPTTAMDTVAEHYNPLIAAIADIEVPVVVAI
                     PGACVGAGFGIALAADIRVAGTKTTFATAFTGIALASDSGLSHALVDALGSSRAAGLML
                     LGDRVTADQALDWGLVHRVVADEDVLTTAHTLATTLAAGPTAAYREVKSLVAASVGGPA
                     ESLERERAAQQRLGTTADHKAAVDAFLAKKKPAFTGR"
     aSDomain        complement(22509..23240)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DFR67_RS16285_ECH.1"
                     /evalue="5.80E-50"
                     /label="DFR67_RS16285_ECH.1"
                     /locus_tag="DFR67_RS16285"
                     /protein_end="250"
                     /protein_start="6"
                     /score="161.8"
                     /tool="antismash"
                     /translation="TTDGLATITLARPAAHNALDVATKLALLDAVTTAAKDPSVRAVLI
                     TAEGKNFCVGQDLSEHVSALEADPTTAMDTVAEHYNPLIAAIADIEVPVVVAIPGACVG
                     AGFGIALAADIRVAGTKTTFATAFTGIALASDSGLSHALVDALGSSRAAGLMLLGDRVT
                     ADQALDWGLVHRVVADEDVLTTAHTLATTLAAGPTAAYREVKSLVAASVGGPAESLERE
                     RAAQQRLGTTADHKAAVDAFLA"
ORIGIN
        1 gtggaatcca gcggcacgag aggattggtt tcgggatagt aggcggccgc gcaacctcgc
       61 ggcgtcgcgt actcgactat gcggaacgac ggtgcgcacc gaatgttgtc atcgtcgtcc
      121 caccgggagg tgatgtcgac gatgtcgcca tcgcgatgac cgagggccgc tatgtcctct
      181 cggtgcatga agatgaccct ccttccgccc tctatgcccc ggtaccggtc gctgagtccg
      241 tagatggtcg tattgaactg atcatgactg cgcagtgtct gcaagatcag atgatttgcg
      301 ggaacctgca acacctcgat cggtgagacg acgaattcgc cccggccaga ctccgtttcg
      361 aagctgcggg tatcccgggg cgggtggggg aggatgaagc cacccggtct gcggacattc
      421 acctcgtagc catcacagcc gggcacgacc cgcgagatgt gggcgcggat ggtgcggtag
      481 tcctcgcgca tctcggccca gtcgatgcca tgacggtcgc ccagggtggc ctgtgcgata
      541 ccggtgacga tcgcgacctc tgatcgcagg tgcggacttg ccggtgcaag cggtccgcgg
      601 gaggcgtgta ccgaacacgt cgagtcctcg acggtgacga actggggtcc gctcgcctgc
      661 acgtctttct ccgtgcggcc cagcgtcggc aggatgagag cggtgtcgcc gcacacgaga
      721 tggccccggt tgatcttcgt cgagatctgc accgtcatcc gggcgttccg aagcgcctcg
      781 aaggtgacat cactgtcggg tgtggcctgg gcgaagttgc cgccgagacc cagaaagaag
      841 tgggccttcc cgtcgcgcaa cgctcggatc gaatcgacgg tgtcgaggcc gtgttcgcgc
      901 ggtggatcga aggcgaactc gcgctgcagt gagtcgagaa agtgctgcgg cggcctttcc
      961 cagatgccca tggtgcggtc accctgcacg ttggagtgcc cgcgaatggg gaacagaccg
     1021 gcgccgcgct tgccgatatt gccctgtgcc agtgcgatat tcgtgacttc tttgatggtg
     1081 gccaccgcgt tgcggtgctg ggtcagcccc atcgcccaac agaaaaccgt ggctttcgag
     1141 tcacgcagga gctcggctgc atctgtgatc tgctgacggg tcagaccggt cgtcgatgtc
     1201 acgacgtccc agtccaccgc ccgcacgtgc tcgcgccagg cctcgaaacc ggtggtgtgg
     1261 gagtcgatga agtcgtggtc cagcgcgtcc cactcgacaa gcaacgatcc cagggcctgg
     1321 aacagtgcga ggtcgccgtt gagagcgatc ggcaagaaca tgtcggtcag gtcagttccc
     1381 ggtcccacca tccctcgcgg ggtctgcggg ttcttgaagt tcaccaaccc ggcttcacgg
     1441 agggggttga tggccaggat cgtcgcgccg ttctgtttcg ccttctccag ggccgagagc
     1501 atccgcggat gattggtacc cggattctga ccggcgatga tgatgagttc ggcgttgtag
     1561 acgtcgtcga gagtgacact ggccttgccg atcccgatgg attcctggag ggctatcgag
     1621 gtcgattcat ggcacatgtt ggaacagtcg ggcatgttgt tggtgccgaa cgcgcgggcg
     1681 aacagctggt agacgaaggc agactcattc gaggcccggc ccgaggtata gaagatcgcc
     1741 tcatcaggtg tggcaaggcc gttgagttcg tgggcgatga gtgaaaacgc ctcatcccac
     1801 gcgatgggtt cgtagtgggt gccgccggga cgtttgatca tcgggtgggt gatgcgaccc
     1861 tgttgaccaa gccagtgctc ggtgtggctg tccagatcgg cgatgctgtg agccgcgaag
     1921 aaccctggcg tggcccgggt ggtcgtcgct tcttccgcca cggccttcgc accgttctcg
     1981 cagaactcag cggtgtgccg atgaccgggg tccggatcgg gccacgcgca gctcatgcaa
     2041 tcgaaaccct cggcctggtt cagcttcagc agtgttttcg cggtgcgaac cgtacccatg
     2101 tgtcccagcg ctcttttcat cgagacggcc acggcggtcg ctcctgccgc gtggctcttg
     2161 ggtcgctcga tgtcgagctg gtcgaggtcg cgctcgttgt tgccgttctt ctcaggccgc
     2221 tcgttgttgc cgttcttctc aggcatggtg ccctttcgtg tgccgcacgc tcgcggccgc
     2281 cgatcgatca tcctcgtaca gcatttctac ccaactatgt ccggcctcaa gcctcctcac
     2341 gcagaccgcg atgacagttc ccgaatgacg tggcgggccg gagcggtgat ggtgacgagc
     2401 ctggcgaccg agctgatggt caccgagtcg gtggcttcga ggatgtgttc aacggcgtgc
     2461 agactctgcc gggcggcatc ggccgcctgc tcgacatcgg tctggctcgc cgcatcgtcg
     2521 gaactcttca gaaccagctc ggccagatgc ccgaacatct ccgccagaca ccgtcgcgtc
     2581 tgtttctcga acggacccga ctcttgccga gtggcttgca aggtcttacc cagttcctcc
     2641 acgtgcgacc aggcgtgtcg caaggccgac aatttcgcgt cccagtcgga ggacccgatg
     2701 ccgccggctc ggacccgggg gttgagacgc ctgctttcac gatcgagcgc cacggctcgc
     2761 tcggcgtcac ggaccagcac gacggccgct cgcgcccgca taccggaatc gaaggattgc
     2821 cggtcgtcgc tgagcgctgc tgtgcccatg tgatcgagca cgtcggccag gtcgtcggcg
     2881 acccgccgaa tggcatcggc agcatcgagt tgatgaaccg gcggcgcaat cgtcgcattg
     2941 actgcgatgc cgatggccgc accgatcgcg gtctcgatga gcctgtcgat caacgcggat
     3001 tcctccacag aagccgacgt caggatcagc agggcggtga tgccgatcca cgtgccgctg
     3061 tcaccgaagt aacgccactg gccgaccagc agcccgagga gcactgcaat gaaaagggca
     3121 gcaagatccc aggggatgaa ttcggttgcc gcgctggcca agatgaccgc gatgaacgat
     3181 gctgccagct gctgggcggc ggaacggacc gatcggtaga cggtggcggc gacgatgaag
     3241 acagcggacc acggcgccag gaacggctgc gagaagtcga agacctcggc agcgagtacc
     3301 caggcgatca aggcggcgac gctcgccttg atcgcttgta tcagcgccgc acgctccatg
     3361 ccgcgctgcg tggccgctcg ctgtaaccat gtcgcgggcg cgaggaatac ggtggcgcgg
     3421 cgcgcccatc tgctggtcac cgcgaggagt gaaacgccga gcacagatcc ttccgaggga
     3481 gtggggggcg ggcggcgccc ggcctgctcg atgaacccgg acgcctcgcc gaaccgaccg
     3541 ccgcggcagt tactccggcg tacagcagcg gtacccatct gaccggagag caaacccgcg
     3601 agggcggtgt ttctccaacc cagacagtgg ctatccgact agaacaccga tctccagaat
     3661 cgggtcggca ccacagcaac aggatcgagg gtcgcagcac tcatggaaat cgtcgcattc
     3721 gtcgtgatcg ccgtcgttgt gatcgccgtg gtctttctct tgccccgcac gaaaaagacg
     3781 cagcagccga aggacaatca accgcacctg cagcacgagc accgcaccgg acgggcgcgg
     3841 gcactgcgcg atcggctccg ctccaagacg cccccacatt gaccggttgt tgccggtgct
     3901 gatcactcgg cagtgaacat cggtcgtccg gccacggggt cagcggtgat gcgggcgcgg
     3961 acgtcgaaga ccgatcgcaa cagatccgcg gtcaccaccg tggcgggtcg tccgtcggcg
     4021 atgatctcgc caccacggag cgccacgatg cggtcgcagt agcgcgcggc ctgattgaga
     4081 tcgtgcagaa ccaccacgac ggtcttgcca tgcacgcgga ccaggtcgac cagcaattcc
     4141 atgagatcga tctggtgacg gatatcgagg tacgtggtcg gttcgtcgag cagaaggatg
     4201 tccgtgtctt gagcaagcac cattgctatc caggcacgct gtcgttcgcc acccgacaga
     4261 gagtccagtc ggcggtcggc caatgactcg acacccgcaa gggccatggc atggtgcatc
     4321 gcctcgtcat cggttcggct caaccgcgca aaggtaccca gccggggaaa tcggccctgc
     4381 tctaccagtt cgcgcacccg cagaccagtc ggtgcgatgg cggtctgagg tagtacggcc
     4441 aacgcacgag ccacagcggt cgatcgctgt gccgagatgg gtgtcccgtg taagcggacc
     4501 tcgccgcgcc gggggagaag cactcgtgcc agggtcatca ggagggtgga ctttccagac
     4561 ccgttggggc cgacgagggc agtcagtgtg cccttggtga tctgcacgtt cagatcgttg
     4621 atcacagacc cgccgcggta tcccacctgt aggtcgcaac cctgcagttc agtgttgtcg
     4681 tcgcacatga tgctcccttc ggaccagcca gatgaggtac ggcgcgccga gtaacgccgt
     4741 gagcgcgccg accgggaggc cgctcactgc ggggccggca ccgggtagat cgagggtgat
     4801 actgaaagcc accagatcgg cgcccgagag acagatcgcg ccgaacacga cgctgaccgg
     4861 gatcaggtcg cggtgatccg cgcccaccag tgcgcgcgct gcgtgtggag ccatcagccc
     4921 gacgaaggcg accgcaccag ctgctgcaat ggccgtcgcg gcggcgatca cggcaatcgc
     4981 caagagtgcg aacctcgtat ggctgggccg cgcccccaga cctgtggccg cgatgtcacc
     5041 gaggctcagg acatttgctg cgggcgccaa gaacaaccct gccgcagtga gggcaagtac
     5101 ccaaggccac agagaatccc agtctgcttg ggtacgggcg ttcagggaac cgatcagcca
     5161 acgcagcacc acgcccatcg gcttcccgtc gacaaccagg agtagtgagg tcaccgcacc
     5221 gagtacggcg ccgatcagaa tcccggcgac ggcgagggac cgtcggccga ccaggaacag
     5281 catcgcgccg caggcgactg cgccgatcag ggcagcagcg gttgcgaaat cgttgcccgg
     5341 aaacaggatg agcgacacca ccaccccgag ggcggccccg gaaccgaccc ccgccgtccc
     5401 tggttctgcc agtgggttgc gcatcaccgc ctgtagcagc gcacccgaca gtgccaggag
     5461 tgcccccgcc ccgattccca ccagcactcg cggcagtcgg tacctgaaca cgatcgtctc
     5521 gtgcgagcgg actgcggagg aaccggacag tgctcggagg gtgtcgccca tgccgagttc
     5581 ggaacggccc acgaggagat gcgcgacgat gagtccacac aaaatcgtgg cgccgccgat
     5641 gaggagaacc accgaccgtc tcaccgggaa gactcttggc ggtgcaggga atacaacagc
     5701 gccggtaccc cgatcaaggt ggtggtgatg ccgacgggaa tttcaatggg gtacagcact
     5761 gttcgtgaga cgaggtcggc ggctgcaaga agtgtcgcgc cgacgatcgg ggtcagccag
     5821 aagacacggc gagagctcgt ggtctgtagc gcccaccggc tcaggtgtgg ggcgagcagc
     5881 gccacgtagg cgacggggcc gcagaccgac gccacgacag ccgccagcac cgctgcgcac
     5941 accagagcca ggacccgcga tcggacgaca ttgatcccca ggccggcggc gacgtcgtcg
     6001 ccgagggcca gcgccgccac ccgatgtctc aggagatagg ccacggggat ggcaaccatc
     6061 aaccagggca tcacaactga gagatgaggc catccacggt cgctgaggct gccgagcaga
     6121 taccggaaca agagcgggat gttgccttcg gtaccgaggc tgacgagggc gatgacgagg
     6181 ccggacgcca tggcgctcgc ggcggacccg atcagcaaca cctgcgtgct gtcccgggta
     6241 cgcccgacgg ccgcgatgac cactgttccc gtggcaagag cgccgccgag cgccacatat
     6301 ggtagtcccg cgaggggcac aggcaacgcg cacaccgtca ctgcggtgag aaccaccgcg
     6361 gcacccgacg acacacccag gatctccgga ccagcgatcc ggttctgcat tgcgtcctgc
     6421 atcaagatcc cggcgagggc gagtgcggca cctccgagca gccccagaag tgttcgtggg
     6481 agtcgcgcgt cgaagacgtt cgggtgtagt ggcgctgagg ggtccagcaa cgccgaaagc
     6541 gcctgcgcgg gagtcaaagt cggatctccg agacacagcg acgccgcgag cacggcgccg
     6601 gccgcgagga gcccggcgac cacgagcgtc ggtgtgcgcg aaccgtaccg cgttcgctcc
     6661 cggctgttga taatggttat catttcgcat tacatcattc tgcaagggag atcgaatgcg
     6721 caagttcacg acttcatcca ggtttcagcg gacggcggtg gccgtctcga cgttggcggt
     6781 tctcacgaca acggcgtgcg caggaggcga ctccgactcg ggtaccggcg ccatctcggt
     6841 gaccgatgca acgggcgcga ctgtgtcgtt ggacggacct gtcgatcgga tcgcctgcct
     6901 gacgatgatt tgtgtcgacg ccctcaagga ggtcgggata acgccggtcg cgtatcgcga
     6961 ggatctggcg accgacgacc gattcttcgg accagatgcc gggatgcgga agatcaccgg
     7021 tggtttcggt gaagagaacg tcgaagacat tgcgctgtcc gagcccgatc tcgtgatcgg
     7081 cttggcgggc gttcaggacg gcctacgggt ggcagtggaa gaatctgcgc cgctctacct
     7141 ggtcgatccg gcctcgtggc agcagtccgt cgacttcctg cgcacggtcg gtcaggtcac
     7201 cggtaaggag tccgaggcca cagcggcggc ggacgcgttc acggagaagg tagacgccgc
     7261 gaagcagagc agatctgacc tcacgacgtt gtcgatgtac ggcgagccgg ggagcctggg
     7321 cgtcgactct gtcggcacgc cggtggggtc actgctcgcc gaggtcagca ggtacccctg
     7381 ggcttccgga acggacgctt ttgcaacggt gtccgtcgag cagatcgcgt ctgtgaatcc
     7441 cgacgtgatc ttcgcgcagg ccttttccgc gggctctgat tcagagccgc tctcggtgcg
     7501 gctcgcggcc aaccctgtgt ggccgaccat ctcggcggct gagaacgatc gggtggtcga
     7561 ggtggaggcg gacgtgtggg ccaccgggcg cggcaccgtg tccttgggca tcgtgctcga
     7621 tgtggtgatg gcagaactcg gacccgcctg acactattga aaatgattgt catttggttt
     7681 accgtgggaa ccgcttggta ccaagagtcc gattcggctg tctgcagctg aattcaactg
     7741 caataaaagg agattcatga tcgacaatga gttcttccgt cccatccagg cgcctgtcac
     7801 gctggcgacc cactcggccg gacacagcaa cgccctcgtg gaaaacccgt tcgacgatgt
     7861 ccaggacacc gacgccgagt agttctcggg tcttctgacc cgtcaatgcc cgcatgccac
     7921 gcaagccgca cagcttgcgt ggcatgcggg gccgcaacga gaagcgagac cgtgcactta
     7981 tcaccgaaca cctcgatcta tcgagcccgc aatggctatg tactgcgcac tgccgacgac
     8041 cgacattacg aactgaccct gcccgaccgt gaggtcgacg agctgctcga cgtgctcggc
     8101 gggaatgggg taccagaatc gactgatgtg tccgcggtgg tggccgcgtt ggtcgactcc
     8161 ggggacgtcg tggtgcgcgc gactctgccg accgtggcgg tgcacggatc tggtcgcatc
     8221 gcggagaagg tcgtaaatat gttgagtagc agcataatac gcagtaccga ccaggcggac
     8281 gtcgtttgtc acctcagtga cgacgaggtc gaccccgagg cgatcgggca ggtggatctg
     8341 gcgtgttacc gggatgggat cagtcaggtg atcacgccgc gggccgtcgc tcccggcgac
     8401 gtcatcggtc gccgccgcgc gtgcaacctc caccgcgacc ggattccgtc gcagtatcgt
     8461 cccgtcggcg gccgacgact cgattcgccg gagcacccgg tgtccgatcg cgcggccgag
     8521 ctgatcgcac acctgatagt cgacgagatc ggtcgccgcg gcgtcgcggc ggacgagcgg
     8581 tcgcactacc tgctgaccgt tgtggacctg cgaacgctga cgtcggtccg gcggccggtg
     8641 ttgccgattc cttctgcgcc acagtgatat cagagctcgt tcgggtcggc gacaccgcgc
     8701 tacgaacact cgtcgcgctg ccggctaccc gcccgcacgc cgtcctggtg cttcgtacgc
     8761 cctacgatgc agaccagcac gtggacgaag cgcgtcagtg gacgctgcga ggtgtggcga
     8821 tggtcgtgca agatgtccgc ggacgatacg ggtcgtccgg gcgcttccgt ccgtatgaga
     8881 acgaaggctc cgacgggctg gcgactgtgg aatgggtgcg ccgccagtgc tggggtcgcg
     8941 cgcccatcat cctctacggc acatcgtatg ccgcccactg cgcggtcgag accgccatcg
     9001 ccgcagccag ttccgacatg gacgtggtgg acggggtctc ggtggccgtt cccgcgctcg
     9061 gactcggcga gagcgcacgc aacgtcgatg gatccttcca gctcgaatcc cgcgtcgggt
     9121 ggtggctcga acacggcgag ggacagcggt caccgggaac agcgatcccg gacggtgcgc
     9181 tctcgacctt gcccgtggtc gacatcgggg ctcgggtcaa tccaccgatc gaggcgtggc
     9241 acagggtctt gcgggcggcc cgtcgagacg ccgaacgcgc cacgagcact gcactactgc
     9301 ggtgtccgct gctcgcgatc ggcggtaccg ccgactggtt cgcgcaggac accatcgacc
     9361 tctggtcatc gtggggtggg ccttctgccc tcgtcatcgg cccctgggac cacggtttgc
     9421 ggaactcggg ccgcgctcga cacatgcagt cgtggattgc cgatgtggtc gccggtgaag
     9481 cgccgagcgg tgcgcaggtc cacggtctgc ctgcggggat tcgacgatat gcgcagtggc
     9541 cgtcgagcga gacgcggatc cacctgaagg gcggtcattt ccgtagcgat ccctcgacac
     9601 cctttccctc tttggcattc ggcgtcgaca tcgggcgtcc ggcccgcagg cccgactgcc
     9661 tgctggtgga cttcgaacac cgcgcatcgg tcgtagtcgg gagcccgacc gtccgaatag
     9721 tgagctcgca cggccaccat caatggtcgg cagtgctcgc ggtccgccgc cgcgacggac
     9781 ggctcgaaca gctcgcccac gggacatcgc cgcggccgga cattcgtctg accccggtat
     9841 ccacccatct cgaaccagga gagaccatgg ccgtgatcat ctcggcgcac tcgttcccgc
     9901 ggcatccgcg cgatctgcag gtgggcgatg accctctcac cggaaccacc atgcggacga
     9961 ccgaccgcga ggtccacggc gtgttcgtgg agctcccggc gtgagcggcc cggcgatcct
    10021 gacggccgaa gacctcgtcg atccgtatgc cggcatcatc cgagcgctgc accccgtcga
    10081 gcgtctggac ggtatgcccg atcgttacgt cggcctgacc gccgagatcg cagacaccag
    10141 ggcacatggc aattggccca gtgacctggt gtcgctcggc accacattcg ccgacgacgc
    10201 gggtgctcgc atcgctgcca tcggagaggc cgtggagcgc tactgcggaa accatgtgcc
    10261 tgtgggcctt gtgcgcgcca gcgcccgcga actgcaggct tccggggtcc gccatctcgg
    10321 gcccgcgcag ctgaacttct tcgcaccctg gcagctacag acgccggggt tccccttctc
    10381 gcagttcacc gacgacacgt cggtggtgtg ggcgaaggga tccggtgacg atgggctacc
    10441 gacgctggtg ccggcgtcgt tcgtgtacct caactggagg accggtgggc gacaacgcga
    10501 accgtggctg caccatctca actatgcggg gatcgccacc ggagcgggtc tcgaggacgc
    10561 ggcgacccgt ggcctgctcg aactggtcga acgggattcc ctgtcgctgt ggtggcatct
    10621 gaacctgcct gcccgtggga tcgccctcga gagtgttccg ggcttgatcg atgacctcgg
    10681 cgacacccga ctgcgttgcc acctactcga actgcccgcc ttcttcgggg tgccggtagt
    10741 cgccgcggtg atccacgacc ccgaactggg aatcgtggcc ggcggcttct ccgcgaaact
    10801 cgacccggcg gcgacagccc gaaaggcggt cttggaggca ctgcacagct gggtcttcac
    10861 ccgggggctg acggacgccg acggctgggt gttcgcctcc atggaagccg gcgtcctctc
    10921 gagaggcctg tatctcgatc atcgagcgga tcggagctac ctcacgggcg ccggtgcgcg
    10981 cagcgaacac attcgcgacc tgggcgctca ggcccaggtg tggctcgacc cgcgaaccca
    11041 gcaggccctg ctgtcgcgtt tcaccgagcc ggcctccacc atcggcgtcg gggagatgcc
    11101 gaccggggac atcgggacct tgcatgcccg attgcgcgag gccgggcatc acgtcgtcgt
    11161 ttgcgacatc accacgccgg acgtcgcatt gaccccgttg cgggtcgccc gcgtgtgcgc
    11221 cggtggactc atcccgaatg cgcctgccgc atttccgtat ttcggactcg cgcggtggcg
    11281 agaggtcgca caggcggcgg cggtggccgg tgatcccgac gatcccgagt ctctactcct
    11341 gataccccca ccgagcctgt gaatcctttc cgcaccttcg tacttgcccg atccatctgc
    11401 tgggcaggga atgcggtcac cctggtcgcg ttgcccttgt tcgtctacca gcagggtggg
    11461 tcagcgctcc tgaccggggt ggcgttcgcg gtcgagtcga tgccctatct gctgttcggg
    11521 ctttttgccg gcgcaacggc cgatcgattc gatcgcaaga gaatcctggt ggtgtcgcag
    11581 attctcagcg cggtcatcct gtcgacgatc ccgctcgcag ctgtcacggg gatcgcctcg
    11641 attgcccatg tgctggtggt ggggtttgcg gtctccacgt tgttcgtcta ctacgatgcg
    11701 gcaaccttcg gagtggtgcc cgcgcttgtc ggccgtgacg gcatagccga tgccacagcc
    11761 cttttggtca cgacaggaac cgtcatagga atcgcgggac ccttgctggg tggtatcgcc
    11821 gcttcggcct tgagcccggc cggcgccatc gcgatcgacg cgggctgtta cgtcgtcgcg
    11881 gcgctgatca ccgctacggt cgctgtacct gcgagtaccg gggcagcgga cgccgaccgg
    11941 cgagtgtggc aacagatctc cgaaggcctg cagtacatct ggcgccagcc ggtgatcagg
    12001 atgctgactc tggtcggaat cggggtgagc atggccaatg gggtcgtggt cgggctgatg
    12061 gtggtggttg gtgtccggcg gctcggactc gacgacggtg atgcacgcct gggtgcgctc
    12121 tacgcggcga ctgcgctcgg agccttcctg atcagtctcg tcagtgcaca tatccagcgg
    12181 cgcatgggca ccgggaagat cacgctcgtc gggataggag tggctgcgag tgcgatgctg
    12241 gtgtgggcgc acaccacgtc ctttgcagca tccttgctga tccttgtcgc ataccaggcc
    12301 gccaacacga tggtcgtggt caacgggatc gttgtgcggc aatcgatcac cccggatcat
    12361 ctgcagtccc gggtgaacac gacagcccgg atgatcgcca tgggcggcac cccgttcggt
    12421 gccacactcg gtggagcggt cgccgaggtg gccggtgccg gcgtggcact gtcgataggc
    12481 gcagcggcac tcgtgctggc ggtcgccggc ggcctgcacg ccggcgtggg gcgcttaccg
    12541 ttgctcgccg agctctcggc gggcgcccac ggcaaaggcg agtaagggaa tctgggtgtc
    12601 gtccagcgac aggacgtcgg cgactcgatc gtcgtagaag ccggagatcg cgcagcagga
    12661 gagttcgagg gcctcaccca ccagatagag gtgtgctgca gccaccccgg cgtcgacatg
    12721 cactgtccga tagtgtctct cggagtactt caccagcgtc gcggtcattt ctccggcgag
    12781 gacgaggcac accgaggcgc gttgcgcgaa ctcggcttgc acgaggcact caccgaaagc
    12841 ggtgcggatg tcgcccgtcc tacgctgaat gagccggtgc cgggccgggt cgaacgtgta
    12901 gatggccgaa gcgatgtcgt cgatgggttc caacgccacg acgtggactg tcatcgagtt
    12961 caggccaccc gcgctcggat ggatatcgag ggtgtgtgct gttcgctcgc cggtggtcac
    13021 cgtgcgttgc ggccccaggg cccatcgcaa caaggtggac aactcgagat gtcggagcga
    13081 gccgaagacg taccgtgaac gacgctccag cagtgcccgg cccaggggaa gcgtcggttc
    13141 atcaccgggc gccctgagag ataccgatcc ggtgctgtcg ctcagggctg tcgacatgct
    13201 gggatcaggg gcgttgtcag agagcgcctg gtgtatccgc tgtacacgat cgattcgcga
    13261 agagaactgc gtggtcatct cggaagtata acgacaatca ttgtcgataa tggttcgtcg
    13321 aggtcgttgg tcgacgcgaa gtggcgcctc tctcgagaac tttcggtgcg cgcatcgtca
    13381 acgatccatg cgcggatgtg caagtatccc aggtcacatt tatccatgct ggtcacagta
    13441 ggcaaaacgt gagaatgcct gaccagaccg ccgcaggcga gtcggcctgg caccagacga
    13501 taggacaatc atgaccgcag tacaggattc gttgatcgca ggcgggggtc tgccggacga
    13561 aacccccact gaactcttcg tcgccggcac atggcggcag tcgtccgacg ggtcgagctt
    13621 caccgacctg aacccggcga cagaagaagt gctggcagag gtgtcggccg ccactgcatc
    13681 cgacgtggat gaagcagtcc gcgctgcacg cgcccagctc ggcggagagt gggggtcgat
    13741 gcccggcgtg atgcgcggga agatcctgaa caaggtggct gacctcatcg agcgggacgc
    13801 cgatgcgctg gccacccttg aatcactcga catcggtaag cctctcggac agccggcgat
    13861 gctcgacatc ccgaacgccg cggcaacgtt ccgacacttc gccggctggg ccgacaagat
    13921 caccggccag acgatcccga ccgcagggta tttcggccag cagacgcact cttacacggt
    13981 gcgtgagccg gtcggtgtca tcggcgcgat cgtcccgtgg aacaccccgc tgatgatcgc
    14041 ggcgtggaag ctcgcgcccg cactggcagc gggcaacaca gtggtcgtga agccgtctga
    14101 ggatgcgccg ctgtcgatcc tgcacctggc gaagctgttg caggagtcag gtattcccga
    14161 cggtgtggtc agtgttgtac ccgggctggg tgatgtggcc ggcgatgctc tggtcaggca
    14221 ccccgatgtc gacaagatca gtttcaccgg cagtccgcgg gtgggcaggc tcatcgccaa
    14281 gatcgccgcc gacacgttca aacgcaccac cctggaactc ggtggcaaat cgccgcagat
    14341 cattctcgcc gacgccgacg tggaggccgc catcaacggg acggcgatgg ggttgttctt
    14401 caaccagggc gaggtgtgcg ctgcgggcac ccgcgtactg gtccatcgct cgctgtattc
    14461 gcaggtggtc gacggcctcg ccgccgcagc gtcggcgcag gtcctcggcg acccccgcga
    14521 ggcggcgacc acgatggggg cactggtcaa cgccaagcaa cgtgattcgg tactcgccta
    14581 catcgaggcg ggtaaacgcg atggcgcccg ggtggttgcg ggtggtcaca ggcatggcga
    14641 caaaggcttc ttcgtccaac ccacgatctt cgccgatgcg agcaatgaca tgaccatcgc
    14701 acgcgaagag atcttcggtc ccgtgggcac cgtcatcccg ttcgatgacg tggatgaggc
    14761 gatccgtatt gccaacgaca ccgagtacgg actcgcagcc agcatctgga cgcgcgatgt
    14821 gtcgtacgcc cacagactcg ccgcacaggt ccgcgcgggg gcggtctggg tcaacggttg
    14881 ggcggcgatt gatccagctc tgccctgggg cggaatgaaa tcaagcggca ccggccggga
    14941 actcggctgg gccggtatcg aagcgaacac cgaagaaaaa gttgtcaccg tcgtcctgtg
    15001 acgaccggaa ctgtagatag ggagtagata tgaagactca ggcagcggtg ctctgggagc
    15061 ccggacaaga ctggcagata gaggaactga tcctggacga tccgaaatac ggcgaggtga
    15121 aggtcgagct cgccgcctcc ggtttgtgcc actccgacga acacgtccgc gatggcagtg
    15181 tgccggtggg tctcttgccg ttcatcggtg gccacgaagg agcgggtgtc gtcacacaga
    15241 tcggtcccgg cgtgaccagc ctcgaggtcg gcgaccacgt atcgctggcc ttcattcctg
    15301 cgtgcggccg gtgccgcgag tgcgccaacg ggcagtccag catctgtgat ctcggtgctc
    15361 atctgctcga gggctaccag gtgtccgatg gcacggcgag acaccacgtt cgcgggaagg
    15421 acgctggaat ccagtgtctg ctcggaacat tcgcaccgca cacagttgtg aatgaagcgt
    15481 cctgcgtaaa gatcaccaaa gacattccgc tcgacaaggc cgctctggtc ggctgcggtg
    15541 tcaccaccgg ttggggttcg tcggtctacg cagcgggtgt cggtgcgggt gagacagtgg
    15601 tgatcctggg aatgggcggt atcggctgcg gtgctgtgca gggcgcagcg ctcgcgggcg
    15661 cccggcacgt ggtcgtcgtc gacccgtcgt cgttcaaacg ggagcaggcc aagatcttcg
    15721 gtgcgacgca cacggcggcg gacatcgatg aggcgctgat cctggtgaac gagctgacct
    15781 ggggtcacct tgccgacaag gtcctgatca ctgttgatgt cgcgcgtgga gagctcatcg
    15841 cgcctgcgat gagcctggtg gcgaagggcg gtgtgtgcgt acaggtctcg gtcggcaacg
    15901 ttgccgacat cgatacgaag ttgagcctgt tcgatctgac ggcgatgcgt aaaacgctca
    15961 agggcgcctg gttcggcaat gccaacatcc gtttcgacat cccgcacttg ctgcggctgt
    16021 acatggaggg ccagctcaag ctggacgaaa tgatcacccg tgagtacacc ctcgaccagg
    16081 tcaacgacgg atacgaggcc atgcggcggg ccgaaaatgt ccgcggactg atccgctact
    16141 gacataccgg taccgacgat tcgccctcct tccgttgcgt agggagggcg attcgtcgcc
    16201 ggcccgcgag cgcgctcagg cctcgcgata atggcgcggc gacacgccgt acgtctgttt
    16261 gaagagccga gagaagtgcg aagcgtcaac caggccattg gtggcgcaga tcgagcccac
    16321 actgcggtgg ctctgtgtcc ggtcggcaag atcgcgtcta catcgttcga gccgacgttg
    16381 ccggatgaag cctgccaccg acagcccatc gtaggcgaag agtttctgca ggtagcgcac
    16441 cgatacgtga tggtgggatg cgaccgcggt tgggcacagg gtggggtccc cgagatgcgc
    16501 ctcgatgtac gcgcgggcgc tgaggagcac tgtctgtccg gatcccaacg cgtcgacagg
    16561 cgccgacgac ctgaccaccg cgctcacgat gtcggcgacc gcatcttcga tcagcggcgt
    16621 tgccgcactc gacccttgat ggttcgagcg taacgacaac aagagcgggc ccagcagagc
    16681 gcccgcccct gtggtggtgg tgatggtcct tgcggtggcg tccgtcagtt cccggtcggc
    16741 gacgcgcagc gcctggcgcg ggatgacggc gacgagcatg tcgaatgaat cggtcaggtg
    16801 caaaccgtat tcgacgctgg tgtcgtagat cgccagatca cccggagcga gcgtggcatg
    16861 ccgaccattc tgctgtacgg tgctgtggcc atgcagttgc agtcccacct tgatgacgcc
    16921 cgggtccgcg cggcggatgg tggccaccga gcgacggaca tgtgaacagt caccgagaac
    16981 ctcagccagt tggagatcac cgacggtgat cgagctcaac gcccccgaga agtcgcctgg
    17041 ccggtggtcg ggtgaggcgt cgagaggtac gaacgccgac gaaatcgctt cgcgccattc
    17101 atcgaaaccc acccgatcat ggggcggggc ggtcgtgatc ccgtcagggg tcacctggtc
    17161 gatcgattcc gactgcggca tacggctcct cagatcttgg gcctcttgtc gatcaggcgt
    17221 ttggctttac cgacggagcg ttcgatgcct tccgggccga cgatgtccac agtgaccgtg
    17281 acgcctatcc ggttcttgat caaggtctgt agcgccatcg acgcggcggc atgctggtcc
    17341 gagagcaccc cgggccgggc ctcgaccttc acgatgaggt tgtccatccg cccggcgcgt
    17401 tcgagcacac actggaactg tggtgagagc gcaggaacgg tcaggatcag ctcttcgatc
    17461 tgggtgggga agaggttcac cccacgcagg atgatcatgt cgtcggtgcg gccggtgact
    17521 ttcttcattc gccgcatggt gcgcgcggtg cccggtagca gacgggtcag gtccttggtc
    17581 cggtaacgga tgatcggcat ggcttctttg gacagcgagg tgaacacgag ctcaccctcc
    17641 tcgccgtcgg ggaggaccgc accggtctcc gggtcgatga tctccgggta gaaatgatcc
    17701 tcccagatgt gtaggccgtc cttggtttcg acacattcca tcgccacccc cgggcccatc
    17761 acctccgaca ggccatagat gtcgaccgcg tccatgttca gcgaggtctc gatctccttg
    17821 cgcatctcct cggtccaggg ctcggccccg aagaccccgg tccgcagtga tgtcgtggcc
    17881 gggtcgatgc ctttcttgat catcgcgtcg acgatggtga gcatgtagga cggtgtcacc
    17941 atgatcgcgt cgggttcgaa atcctcgatg agctggatct ggcggtcggt catccccccg
    18001 gacatcggga tcaccgtgca gccgagccgt tcggcgccgt agtgcgcgcc gagtccgccg
    18061 gtgaacaggc cgtagccgta ggccacgtgc accttgtcgg ccgggcggac cccggccgcc
    18121 cgaaggctgc gtgcgaccag gtcggcccag ttgctgatgt cgttcgatgt gtagccgacc
    18181 acggtgggcc gcccggtggt gccggacgat gcgtggattc gggagacctt gtcctgcggc
    18241 accgcgagca tcccgaacgg gtagttttcc cgcaggtcgg ccttcgccgt gaacgggaaa
    18301 ccagcgaggt cgctgagatc cttgagatcg gtggggtgca cgccggcggc gtcgaacgcc
    18361 gtccggtagt gcggcacgtt gtcgtaggcg tgcttcagcg accactgcag gcgctgcagc
    18421 tggagtgtgg atatccggtc ccgcgttgcg aattcgatgt cgtcgccggg tgcggtcgga
    18481 gtattcgaga ggacgctggt catgggtttc tccagtggtg gtgcgtaagg tgtcaggcgt
    18541 cgaaatcgac ggtgacggtg tcgctgacgg ggtaggtctg gcaggtgagt acgaagccgg
    18601 aatcgacctc ggaatcctcg agggcgtagt tgcgacgcat gtcgacctcg ccgccggtga
    18661 ccttggcgcg gcaggtcccg cacacgccgc ctttgcaggc gaacggaaga tcggaccgga
    18721 gttgttctcc ggcatcgaga atggactcgt cccgggggag ggttccgctg accgctcgac
    18781 cgtcgagggt gatcgtcacc tcgctgctcg gcccggtgat cccgggttca cgatgcttct
    18841 cgagaggtgg gggcacgtcg tcgacgtaga acagctcgtg gtggaccgcg ctcttgggga
    18901 cgccgaggtc ggcgaggacg tcctgcgcgt cgttcaccat tccaaatggt ccgcataacc
    18961 agaagtcgtc gatgtcggcg atggggacga gggtgtcgag gatcgcgcgc aggcgctgcg
    19021 catcgaggcg gccgctgaac agttcgactt ctcgaggttc gcgggacagc acgtggatca
    19081 cgtcgaagcg ggagccgtac tcgtctttga ggtcggcgat gtcttcggag aacatcaccg
    19141 agcggctgcg gcgattgccg tacagcaggg tcacctccgc ttccgggttg gcgagcatag
    19201 aaccggcgat ggagagcata ggcgtgatgc ctgacccggc agcgatgagg acatgccggc
    19261 cacccgcgtc gggatcggcg acgaagtttc ccgtgggccc ttgcacgtcg acgcggtcgc
    19321 ccggctgcac ctcgtggacg agccaggacg agaacagccc gtcggtgacc tcccggacac
    19381 cgacccgggg cgggctgccg accggtgcgc agatcgagta cgagcggcgg tgctccacac
    19441 cgtcgaccgt gcggctgagt gtcagtgact ggccggcgcc gaagacgaac tcgtccgcga
    19501 gagcgtccgg gacgtcgaat cgcacggcga ccgcgtcgtc gcagagcggt tcgacgtcgg
    19561 cgacggtcaa cgtgtgaaac ggcttggtgc gtttgctcgt cggggagact gccggctcgg
    19621 cggtggctgt catgtcagat ttccttcacg tgatcgaacg gttcgaggca atcgagacag
    19681 tggtattggg ctttgcacag tgtcgcgccg aactccgact tcagatgtgt gttccgtgag
    19741 ccgcatcgcg ggcagtcaat gacgcggggc gtagcggtca aggtcagcgg taccgggccc
    19801 gacgatcggg tgggtgctgg tccgggcagc gagtaacccg tgtcggacag tttccggcgg
    19861 ccttcgtcgg agatccagtc ggaactccag gccggcgaca accgcgtcac gatctcaaca
    19921 cgcgaatagc cgtggtcgag cagcttgtgc tcgatgtcgt cgcgcatcgt cgccatggcc
    19981 gggcagcccg aatacgtggg ggtgatcgtc acgaccacgc cgccgtcgtc ggtcacttcg
    20041 acatcgcgta gcactccgag gtcgtccagg gtcagcagcg gcatctccgg gtcgaggacc
    20101 gaggccgcaa tcgtacgcgg agaggtcatg tgcgctgtcg tcacgtcacc acacgccttc
    20161 cggatgtgcc cgtgcgacgc tctgcaattc ggcgatcaag tggcccatgg cctcggtgtg
    20221 gatcccgcga cgtccgccgc ggccaccgat cgttccgacg ttgcggttgc ctggtgcctc
    20281 cagctcggcc gcatgcagca cgtgcgcaat cacggaatcg aactcctccc tggcatcacg
    20341 cggatcgacg gcgaccgaga ccgccgcgag ggcgatctca tcgtcggttg gcaggaacaa
    20401 ttcgtcgatg tacggaaaga cccgctcgag ggcatcggtg attcgtcgtt tggattcatc
    20461 tgtgccacaa cccaaagtga cgacccaccg cgcagcgtag tcgcggtgat aggtcagttc
    20521 tttgacgccc ttcgatgcga cggcggccag gaccgggtca cgtgatgtcc gtagccgatc
    20581 gaagacggcc agtcgccagg tggtgaagag aagtagccgg acctgggtct tggcgaagtc
    20641 tccgttgccg atctcgcaca gccggacgtt gcggaagtcg ctttcgtcgc gaaagaaagc
    20701 cagggcgtct tcggacggca ccggcgaggt gtcggagatg tacggcacca cagcgggatc
    20761 cgcggcggcg gcgcgagcga gaagcaggcg cgcctgtccc aggagatcga ggcccacgtt
    20821 cgcgagtgcc acctcttctt cgagttccgg tgcgcgagtg ctccactgcg cgagccgctg
    20881 ggaactgatc agggcgtcgt cgccgagcat caggcagtac gccgccaggg cggtcagatc
    20941 gacgtcgtcg gggacggtgg tgtcgacgcc ggcaagcgga tcgtcgaagc tggtgccgaa
    21001 ggcccactgt ccgtgagagt cttcgtcgac cagcccttca taggcgttgt cgtggtcaat
    21061 cattgggcca ggcctcacat gtggggaacg tcgtcgggga tgtcgtagaa cgtcgggtgg
    21121 cgatacacct tgtcaccgct tggggcgaag aatggatccc tttctgacgg actggaggcg
    21181 atgatcgagt tggaggcgac cacccagatg ctgacaccct cgttgcggcg ggtgtagacg
    21241 tcgcgggcgt gccgtagcgc catctcgttg tcagctgcgt gcaatgagcc cacatggacg
    21301 tggttgaggc cgcgcttacc acggaggaag acctcgaaca gcggccaatc agccttcacg
    21361 gcagactttt tcggctcgac cggaacatct tcgatcggga cggcaccgtg gccgccttcg
    21421 gcgctctgtt cactcatgat gctgctttct tgtctcgcgc cgcgaatgcc atcgcggctt
    21481 ctcgaaccca ggcgccgtcc tcgtgtgcgg cgcggcgatt ggcgatacgt tcgatgttgg
    21541 aggtgccgtt ccccttgacg acggccagga actcgctcca atcgggctcg ccgaagtcgt
    21601 gcgatttccg gttcgcgttc cacttcaggt cgggatcggg aaaggtgacg ccaagagctt
    21661 tcgcctgcgg gatgctcatg tcgacaaacc gttggcgcag ttcgtcgttg gtgtgacgtt
    21721 tgatgcccca cttcatcgac tgctcggtgt tcggggactc gtcgtccggg gggccgaaca
    21781 tcatcaatgc cggccaccac cagcggttga ccgattcctg caccatggcg cgctgctcgt
    21841 cggtgccgcg catcattttg gtcagcagtt cgaaaccttg gcgctgatgg aacgactcct
    21901 ccttgcacac gcggatcatg gcgcgtgcgt agggtccgaa cgagctgcgg cacaaaggaa
    21961 cctggttgca gatggccgcc ccgtccacca gccagccgat ggtgccgacg tcggcgtacg
    22021 tcagggttgg gtagttgaag atcgaggagt acttctgctt gccctcgatc agcttctcgg
    22081 tgaggtcgga acggtcggcg ccgagcgtct cggccgcgga gtagaggtac aggccgtggc
    22141 cggcctcgtc ctgcactttg gccataagga tcgccttgcg gcgcagcgag ggggcgcggg
    22201 tgagccagtt gccttcgggc tgcatgccga tgatctcgga gtgcgcgtgc tgcgcgatct
    22261 gccggatcag ggtcttgcgg tagccgtcgg gcatccaatc acggggttcc actcgttgcc
    22321 cggcatcgat ggtgtggtcg aactcctgca gcagtgcctc ttcgggcgct ccggaaatgt
    22381 cgtgtgaggt gttcatacgt cctgccttag taaccgaatg atcggttggt atttagtatc
    22441 cacgaaagtg acccggaaca caagatccgg gcggaagatc agcggccggt gaaagccggc
    22501 ttcttcttgg ccaggaatgc gtcgaccgct gccttgtggt cggccgtcgt gccgaggcgc
    22561 tgctgggctg cgcgctcgcg ttcgagcgac tcggccggcc ctcccacgga ggctgcgacc
    22621 agcgacttca cctcgcgata ggcggccgtg ggaccggccg cgagtgtggt tgccagggtg
    22681 tgcgcggtcg tgaggacgtc ctcgtctgcg accacccgat ggaccagacc ccagtccagc
    22741 gcctgatcgg ccgtgacgcg gtctccgagc agcatcaatc cggctgcccg gctgctgccc
    22801 agtgcgtcga cgagagcatg actcaggccg gagtcgcttg ccagcgcgat cccggtgaag
    22861 gctgtcgcaa aagtggtctt cgtgccggcg acgcgtatgt ctgcggcgag ggcgatgccg
    22921 aaaccagcgc cgacgcaggc acccgggatc gcgacgacga ccggcacctc gatgtcggcg
    22981 atggccgcga tcagtgggtt gtagtgttcg gcgacggtgt ccatcgcggt ggtggggtcc
    23041 gcctccagtg cgctgacatg ctcggacaga tcctgtccga cgcagaagtt cttaccttcc
    23101 gcggtgatca ggaccgcccg gaccgagggg tcctttgcgg cagtcgtcac cgcgtccagg
    23161 agagcgagtt ttgtggcgac gtccagcgcg ttgtgcgcgg ccgggcgggc cagggtgatg
    23221 gtcgccagac cgtcggtggt gttcagtaca gcagtcatga tgtgacctca tcccaggt
//
