LOCUS       NZ_CP068988            24414 bp    DNA     circular CON 16-APR-2024
DEFINITION  Bacillus paralicheniformis strain SUBG0010 chromosome, complete
            genome.
ACCESSION   NZ_CP068988
VERSION     NZ_CP068988.1
KEYWORDS    RefSeq.
SOURCE      Bacillus paralicheniformis
  ORGANISM  Bacillus paralicheniformis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4317835)
  AUTHORS   Bhatt,H.D., Bhatt,P.P., Patel,J.H. and Thaker,V.S.
  TITLE     Characterization of Bacillus species
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4317835)
  AUTHORS   Bhatt,H.D., Bhatt,P.P., Patel,J.H. and Thaker,V.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JAN-2021) Department of Biosciences, Saurashtra
            University, University Road, Rajkot, Gujarat 360005, India
REFERENCE   3  (bases 1 to 4317835)
  AUTHORS   Bhatt,H.D., Patel,J.H. and Thaker,V.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAY-2018) Biosciences, Saurashtra University,
            Kalawadroad, Rajkot, Guajarat 360 005, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JUN-2019
            Assembly Method                   :: CLC NGS Cell v. 11.0
            Assembly Name                     :: PMBP_Rhizobaci_2
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: NZ_CP023665
            Genome Coverage                   :: 75.0x
            Sequencing Technology             :: IonTorrent
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003171815.2-RS_2024_04_16
            Annotation Date                   :: 04/16/2024 07:39:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,350
            CDSs (total)                      :: 4,240
            Genes (coding)                    :: 4,181
            CDSs (with protein)               :: 4,181
            Genes (RNA)                       :: 110
            rRNAs                             :: 8, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 59
            CDSs (without protein)            :: 59
            Pseudo Genes (ambiguous residues) :: 0 of 59
            Pseudo Genes (frameshifted)       :: 30 of 59
            Pseudo Genes (incomplete)         :: 44 of 59
            Pseudo Genes (internal stop)      :: 10 of 59
            Pseudo Genes (multiple problems)  :: 20 of 59
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:25:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 220506
            Orig. end                         :: 244920
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP068988.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24414
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24414
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24414
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14414](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14414
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(233..1114)
                     /locus_tag="DI291_RS01265"
                     /old_locus_tag="DI291_01270"
     CDS             complement(233..1114)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011197485.1"
                     /locus_tag="DI291_RS01265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01270"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023857689.1"
                     /transl_table=11
                     /translation="MDNVIELRHVHKSFDGFQLKDFSMNVKKGFVTGFIGGNGVGKSTT
                     IKLIMNLLQPDSGTITVFGLNYKEHEKEIKQRIGFVFDSNIFYEHLTLTEMKDIVKRSY
                     VNWDEQVFNDYVNTFNLPLTKKIKTFSKGMMMKASLAVALSHHAELIIMDEPTAGLDPI
                     FRRELLEILHQLMQDGDKTIFFSTHITTDLDKIADYITFIHKGEHIFTKDFYEIEEQYA
                     IVKGGMELLDRETEQEFIAVRKSTHGFEALTANKSRTENIFGDMVLIEKPTLEDIMFYT
                     KKGAKEHVQLNT"
     gene            complement(1114..1491)
                     /locus_tag="DI291_RS01270"
                     /old_locus_tag="DI291_01275"
     CDS             complement(1114..1491)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178459.1"
                     /locus_tag="DI291_RS01270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01275"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_023857690.1"
                     /transl_table=11
                     /translation="MKIIISNRSKQPIYEQIYTQIKDHILADELKPGQPLPSMRQLAKD
                     LNVSLITSKRAYEELEKNAFIYSVVGKGSFVSDQNNEMMKEGKMKAIEEQLTAAIKNSK
                     DIGVPLTELKDLLTILYQEEE"
     gene            1651..2007
                     /locus_tag="DI291_RS01275"
                     /old_locus_tag="DI291_01280"
     CDS             1651..2007
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419638.1"
                     /locus_tag="DI291_RS01275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01280"
                     /product="DUF4870 domain-containing protein"
                     /protein_id="WP_025810874.1"
                     /transl_table=11
                     /translation="MDEEPSKKAIFSVQLMLGISLILGVIPPLIMFLISRKKDLYYGES
                     SRKALNFHLTIFPLFVIGSFLPSWVKYVILAIETLIIMYAIIRIAFQKPYYYPAIPYIK
                     SKDENIEKRYSHVK"
     gene            1997..2731
                     /locus_tag="DI291_RS01280"
                     /old_locus_tag="DI291_01285"
     CDS             1997..2731
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019419639.1"
                     /locus_tag="DI291_RS01280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01285"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_128823296.1"
                     /transl_table=11
                     /translation="MSNNMLTIGQLAKRTGVSIRTLRYYDKIGLLIPTDYKEGGHRLYS
                     LDELSRLQQIQSLKFIGFSLKDIADLLKSQFIEEQQLSYSISFKKRELISEQERIRQTI
                     DQLDHMKTIISGYEKVDIKLFSFIIHSILFEEENFNEYSQAKGSIHNFRSSERANLDKE
                     YFSLFMDLKELIANETNPESDEALKFIKQLVDISNRTLLKIDTAEIESTVQYNEPNILN
                     PFTEEERAFLKNAFAYMSKLQE"
     gene            2822..3316
                     /locus_tag="DI291_RS01285"
                     /old_locus_tag="DI291_01290"
     CDS             2822..3316
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018410.4"
                     /locus_tag="DI291_RS01285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01290"
                     /product="small multi-drug export protein"
                     /protein_id="WP_025810873.1"
                     /transl_table=11
                     /translation="MVQEIFQRVEEVNIIYQFIAVFIIGFVPFLEAFVAVPIGILLGLP
                     FILVVLVGATANWLSVMAVIVFSSFVRSWFSKKEKNNTDHYINRRFQKAKSYFNKYGVP
                     GISLLGPIIGTNHIGALVCIIAKANKKRIIVWQTVSIVMWAAGTGVLLIFGVDIYNNIK
                     N"
     gene            3728..4030
                     /locus_tag="DI291_RS01290"
                     /old_locus_tag="DI291_01295"
     CDS             3728..4030
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_003097670.1"
                     /locus_tag="DI291_RS01290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01295"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_025810872.1"
                     /transl_table=11
                     /translation="MEPIEVFKALSNESRLQILQWLKEPDRHFEPHEGIDMNTIGVCVS
                     QITDKLKMTQSTASQYLAILLRAGLIKAERIGKYTYYKRDEEAIRKLADFLKTEI"
     gene            4172..5353
                     /locus_tag="DI291_RS01295"
                     /old_locus_tag="DI291_01300"
     CDS             4172..5353
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178463.1"
                     /locus_tag="DI291_RS01295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01300"
                     /product="MFS transporter"
                     /protein_id="WP_035337443.1"
                     /transl_table=11
                     /translation="MFSAWKIYILAIISFLVGTSEYIISGILDQIAQTLGITLAAAGQL
                     ITIFSLVYAVFTPVLMALTASMDRRKLMMYALALFVIGNILAFTLPGYGWFVAARVIMA
                     LGAGMVVVTALTIAAKIAPAGKQGSAIATVVMGFTASLIIGVPLGRMTAEALGWKSVFG
                     GIALLGFIAMIVIFLILPHTEGDKPVPLLQQLSLLKNRKVAMGLSITFFWLGGYSVAYT
                     YLSPYLLTVSGISGNLLSGFLLIFGIASLVGSKFGGYSTDKWGVPFTLVGGMALHIIAL
                     ILLSLVTHSYVGVLLILILWSFAAWSTGPTQQYHLATLEPELSGVLLGINQSMMQFAMA
                     VGAGIGGVFVEKISLASITWFGALEVTIAIVAVLVTFSSHYKRKAGPVREISS"
     gene            complement(5491..6015)
                     /locus_tag="DI291_RS01300"
                     /old_locus_tag="DI291_01305"
     CDS             complement(5491..6015)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018669996.1"
                     /locus_tag="DI291_RS01300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01305"
                     /product="DinB family protein"
                     /protein_id="WP_039073112.1"
                     /transl_table=11
                     /translation="MNFQLEEAIEILERTPQTLSQLLTGLSSPWISCNEGEDTWNAFDV
                     VGHLIEGEKNNWLPRIKLIVTKGATEPFPPFDRFSQLNQNDGKTMEQLLNEFADIRRAN
                     LKTLQQIIDPETDFEQTGMHPEFGIVKLREQISTWVAHDLTHISQIARVLAKRYQDDVG
                     PWRAYLRILAD"
     gene            complement(6522..6875)
                     /locus_tag="DI291_RS01305"
                     /old_locus_tag="DI291_0005"
     CDS             complement(6522..6875)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178466.1"
                     /locus_tag="DI291_RS01305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_0005"
                     /product="DinB family protein"
                     /protein_id="WP_205802181.1"
                     /transl_table=11
                     /translation="MLNYLLTGLSTDWISCNEGEDTLNTFDVVGHLIEGEKNIPRIEII
                     MTKGETKAIPPFNRIDQMQQNAGKPIEQLLSEFVELRRQNLKNLRHVIDKETDFEQAEE
                     HPEFCYPKLERSN"
     gene            7490..7627
                     /locus_tag="DI291_RS01310"
                     /old_locus_tag="DI291_0010"
     CDS             7490..7627
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="DI291_RS01310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_0010"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_006639978.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.3e-09, bitscore:
                     35.1, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKFDDFDLNVKQASEKDVVKPEVGSRYLCTPGSCWKWVCFTTTA
                     "
     misc_feature    complement(7533..7548)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
     misc_feature    complement(7766..7780)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.18"
                     /tool="antismash"
     gene            8145..9935
                     /locus_tag="DI291_RS01320"
                     /old_locus_tag="DI291_0020"
     CDS             8145..9935
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006639979.1"
                     /locus_tag="DI291_RS01320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_0020"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_052252276.1"
                     /transl_table=11
                     /translation="MQSIKKNLTLLCKTIKMIFNITGRNFYFVVILTIGTSLTSVVSVL
                     LFQQLLNAIELKKSLLEEICIMLFIYLGFNLFSEWLNNISSYFNDKLRLLLEYKINFLL
                     IEKSSLLSMRDFENSDIYNKLTRLENEVGYRPFQTFQALLGIISACVTIISSSIILLLW
                     KPYLIIILFLLPFLSLFYYLKIAQENFKIHFERSNSEREAWYISYLMTHDFSFKEIRMY
                     GLRNYFLNRFWRLKQRFRDQDNGINKKKMIYGFIFNTIQDICMGVVVFIAVISAFTGKL
                     LIGNVATYIKSISMVQSNSQSLINSIYQLYESNLYMELLDEFLNLEIETVDSNKIKINS
                     IDEIEFRNVSFSYDGSKNSLENVSFRIKKGDLLAIIGVNGSGKSTILKLICGLYTNYSG
                     EILINGIELKRIDHESYRKCISVLFQDYLKYEFTLGDNVSVGDTSNMNDSEKINKTLEM
                     ANVTFLKDGNKSYQLNSQLGNWFDDGTQLSGGQWQKIAIARSYYREASLFLLDEPSSAL
                     DAISEKHIFESFFKLATNEISIFITHKVEIAKHAGEILVINNGAVEGIGNHSDLIRNCD
                     VYRSLYEKDQIDSNSSMVSN"
     gene            10001..11314
                     /locus_tag="DI291_RS01325"
                     /old_locus_tag="DI291_0025"
     CDS             10001..11314
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="DI291_RS01325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_0025"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_039073114.1"
                     /sec_met_domain="LANC_like (E-value: 2.8e-68, bitscore:
                     228.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDSIRTKTSIRDIASRIADISYVETESKRNELNYRNAGEITQTL
                     SPMTLSHGYPSLCILFSNLGVTDNENCWIEYSNRYVQQIVNLINERGIFGASLFSGTAG
                     IAFSIRIASMRGLYYSKLQKSLDRFLYDQLDEILTNLNFKTNYEMFDYDVMEGLAGIAN
                     YLFIIENDPTSEKYLKKILTYFVSLSGYKEFSGEKIPNWHIKNEFLFSDSEKETYKNGI
                     LNVGLSHGIPGPLIILSKAYKRGILVKGHLEAIKRIAYDLVKLKNQYDNNWGGMIDVQQ
                     YFNQECPLRLPTRSAWCYGTPGTAFSLLTAAEALNDRELSEIAKQAMKDLIGNEQKIFS
                     PSFCHGYAGISYLYKRFYEKTGVQEFDNESKRLKSKTQEFFDFLNPFGYCDIEIKDNYK
                     LKLNSIGLLQGVAGILLSLLSFEENSPSIWNVAFLLDD"
     gene            11337..14414
                     /locus_tag="DI291_RS01330"
                     /old_locus_tag="DI291_01315"
     CDS             11337..14414
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="DI291_RS01330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01315"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_191456882.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.8e-114,
                     bitscore: 378.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.4e-11,
                     bitscore: 42.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.4e-28, bitscore:
                     96.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSYFKPISKYMLRVPLHPNSLIERFYDIEKSIGAIKNDTFLCEQ
                     LLVASENIYKTLLNKDFSTLSKKKKRNLIASLGNYINRAATRTTPFGLFTGVGILDLKK
                     TEVSKPSKINIKKNSRIDAEWLFKLIKKIEVEHFYDLKFKMNTASYRKGNRLHIPYNLD
                     GKTVEINVHYSKPLMLIEKLCIKEHVSFKKMVRALQERYPKRDVDDLVAYVKTLIEKEF
                     IISEIRPPLCNTNLLTYTINKLSKIPFLYEKYGKPLSEVDVLIGKYNDAPIGQGTKNYL
                     TIQEKLRCMHSFTNEKHLQVDTKLDLEGVYINERDIKNINKCITLLMKFASEIEDSKSY
                     KNIFEEYRLKFIEKFGTYVEVPIADVLDEVNGIGALTSYSRPKNRFAQDTPVTTEEHNL
                     WKRYFMNKYLAAVENKHPIIITDEEINKLNMKVDEKRLPSSLELNFIIRKNNNGENLLY
                     LGPNIGSSAAGKTFGRFSYLGDEFSEVLDEVGRELKESEIDQVELCFVPSNIRMANVTR
                     INTPREYNLSMFTNSYNPNNELTLADILVGCDNEKFYLKNKRNGRLLNISGMNMLNLSS
                     SSNIIRLLSDISLNQYLEWSNTPWGVYYKEFIHIPEIRYENIILSNEKWSLQNLRGQFE
                     RTPKIEEFMAEFQKFRRVYSVPDNVYFQFADNRILLDLSRKTNLNLLYKNLFKFPSTAL
                     EKAEAGNPAITLGEEYFSAEAVIPFVLKEEYRDNKSKKEFFNGSIYQQVSYPPFKEWLF
                     LKLYGPEDRQDELIEYMKYFISTQLDRSVYDKFFYMRYNDPKPHIRLRFRSIEPNNLQI
                     IYDKLSEYIIELQKMSIIYEVTINTYFPEINRYGGSVLIKDAENLFYHDSLVVMEILKV
                     MKQNSLSQEQVGVISLLHYLIDFGLSFENQLNYLQLNLKNSDIHKKEFKQEKFDFINEL
                     DSYNNWEKAKKREDLKQIIDILEYRSKSINVYREHINRSNKHTSDFINIMGSIIHLHFN
                     RLFEIDRDFENKLYVYAYQTLYGQRVRRKMLHLQEL"
     aSDomain        11769..12026
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DI291_RS01330_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.60E-13"
                     /identifier="RREFam001.1"
                     /label="DI291_RS01330"
                     /locus_tag="DI291_RS01330"
                     /protein_end="230"
                     /protein_start="144"
                     /score="42.2"
                     /tool="antismash"
                     /translation="MNTASYRKGNRLHIPYNLDGKTVEINVHYSKPLMLIEKLCIKEHV
                     SFKKMVRALQERYPKRDVDDLVAYVKTLIEKEFIISEIRPP"
     gene            14540..15244
                     /locus_tag="DI291_RS01335"
                     /old_locus_tag="DI291_01320"
     CDS             14540..15244
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006639982.1"
                     /locus_tag="DI291_RS01335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01320"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_023857699.1"
                     /transl_table=11
                     /translation="MNNEYILQTRHLTKKYKKSTILNGVSINVRKNTVYGLLGPNGAGK
                     STTLKIISGLLKQTSGEVIFNGNQWTRKDLIYIGSLIENAPLYGNLTAIENLEVINTIL
                     GLPKERIQEVLQVVGLTNTGSKKVMNFSMGMKQRLGIALAILNRPKLLILDEPTNGLDP
                     IGIQELRELMASFPKQGMTVLLSSHLLSEVEHLADDIGIISNGILGYEGKYHSYDNLEN
                     LFTDVVRKHRAQ"
     gene            15256..16014
                     /locus_tag="DI291_RS01340"
                     /old_locus_tag="DI291_01325"
     CDS             15256..16014
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03732.1"
                     /locus_tag="DI291_RS01340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01325"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_026580431.1"
                     /transl_table=11
                     /translation="MYLYLKSEMIKTKRTMIRKMLLVIPLICSILALGFNFLGGPDIVR
                     LSVETIINHWGILWLSVFVALSTGLLNNLEKKSTNFKTIIGLPIDLQKKEISRVLFTTG
                     LMGLGSLLLIIFIILTSLLVNTSPYLVSLSSCILAVTLMFIASLWQIPFCLWLSRKTNL
                     FITLLLNSMLNLNLGSVFAPTGDWWFVPYSWHLRVQMPLTKLHSNGIPLPQNDELLSYS
                     VIPTALVLSLTFFFILTLITVRSFNKLEVK"
     gene            16014..16781
                     /locus_tag="DI291_RS01345"
                     /old_locus_tag="DI291_01330"
     CDS             16014..16781
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03733.1"
                     /locus_tag="DI291_RS01345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01330"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_023857701.1"
                     /transl_table=11
                     /translation="MLQFYRCFLGECKKRKRSIFSLLHLSIPLVLSGVLVMYFLFRNVP
                     VGPEASYIIFFELIGVGTPVIISIICGLVADSENEAGHFQNILGLIQSRTVSFTSQTTM
                     MIFSYFAAMFLTISIYTLALKHLIGVGEVNFTLYYLTGIIFAGTSIFQYFFYQFVGYNY
                     GIGMCSICGFGGVIIAALCLTTIGDKIWWLLPWAWANRFGEYVMDYLKMTGVKPVGNST
                     LVMGGYSFLIMTTGIILLSIVWINRWSGKKTND"
     misc_feature    16787..16801
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 17.11"
                     /tool="antismash"
     gene            16795..17463
                     /locus_tag="DI291_RS01350"
                     /old_locus_tag="DI291_01335"
     CDS             16795..17463
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016937907.1"
                     /locus_tag="DI291_RS01350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01335"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023857702.1"
                     /transl_table=11
                     /translation="MAKILAVDDDAAILRLVRKMLSIKKHEVTTLQSIKDITIEELNKY
                     NLILLDVMMPDEDGFKICEKIRSLIDIPIIFMTAKSDESSIIKGLSIGGDDYIVKPFSI
                     HEVNARIEAHLRREARPKKDTKSVFIDGDILIDLEAKKVMVKGEEVNFTKTQYKICELL
                     ALHKGKIFSKEDIYESVYSIESDSQISTVVEHIRVIRKKIAQFNLAPISTVWGVGYIWE
                     "
     gene            17454..18812
                     /locus_tag="DI291_RS01355"
                     /old_locus_tag="DI291_01340"
     CDS             17454..18812
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="DI291_RS01355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01340"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_023857703.1"
                     /transl_table=11
                     /translation="MGIKNTLSVYFIKWITKLGFAGLFILTLNIGFVTWGINHHFFLPA
                     NEPIKKAEKIQSKVENANYIDPSIIPPELDYTIFNKQTNKIVKSNMSSRNKQRSIEAYL
                     HPSKDRMSSFIRYDSRYESILIHYSLKIQFANIELRKVFPNPGVWISVFSILIYCVYLV
                     WNIRSFSRIIVQENQKLIQVARKIKERDLNIEFPRVRFNEYKDVMGAMESLSEALVKSI
                     QKEIEITNSKSEQISYLIHDIKIPLTVIKGNIELLETMGDEDAKENFSDIMNSIQQIEG
                     YIQEVIDINLDNKQDNTNMEEVSVTDFLCKLEAEVKSLGNNIIVEDWTHKEATSLYIDV
                     ILLIRAINNIVLNGIERTPPHEKVQMIVKQDKDRIQFVIIDQGPGFSEEALKKGTELFY
                     TENFGRTNNSHYGLGLTFTEKVIKQHNGRMKLRNNANNSGEVLVELPILSRKG"
     gene            complement(18930..20666)
                     /locus_tag="DI291_RS01360"
                     /old_locus_tag="DI291_01345"
     CDS             complement(18930..20666)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178468.1"
                     /locus_tag="DI291_RS01360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01345"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_039073116.1"
                     /transl_table=11
                     /translation="MKTENNNSMKPFFTMILTSGVPRLALTVGLAASLVTTLVGLSIPL
                     LTREMVDGFSVNSINLALAGILALVFIVQAVCDGFSTYFLSYAGQKVVASLRERMWFKL
                     LRLPVRYFDEKTSGETVSRVVNDTGIIESLISDHFPQFVSGIITIVGSVIILLIMDWKM
                     TLLMLISVPITTFIMIPLGMKMQRISKTLQDETASFTGHVQQTLSEIRLMKASNAEHTE
                     KTKGLSGISKLFQYGLKEARIFALVSPFMHLVIMIVIVAIIGYGGIRVSEGTMSAGSLI
                     AFLLYLFQIIFPITSFTMFFTQLQKAKGATERIIEILHTEEEEGQEGLEMDISNLPIRV
                     ENVSFSYGDDEPVLREVSFDVDPGQMIAFVGPSGGGKTTMFGLLERFYEPDSGVINIGE
                     TPVNKLSMKSWRSQIGYVSQDSPMMSGTIRENLCYGLDYADSIDDPELWKVAEMAYADT
                     FIKQFPEQLDTEVGERGVKLSGGQRQRIAIARAFLRDPKILMMDEATASLDSQSEAIVQ
                     QALARLMEGRTTFVIAHRLSTIVNADQIIFIEKGEITGRGRHHELIASHALYREFAERQ
                     LT"
     misc_feature    complement(20763..20779)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 23.1"
                     /tool="antismash"
     gene            20862..21506
                     /locus_tag="DI291_RS01365"
                     /old_locus_tag="DI291_01350"
     CDS             20862..21506
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178469.1"
                     /locus_tag="DI291_RS01365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01350"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_095292716.1"
                     /transl_table=11
                     /translation="MTINIKVYSDYVCPFCFLGKDQFEKAIEGKDVEVEWLPFELRPRP
                     SEQLDPLNDPSKLAMWDGAIKPRIEAWGVNMKLPNVSPHPYTDLAHEGYHFAKEHGKAK
                     AYNDRVYQAFFQEDQNIGDIEVLTALAKEAGLDEQAFKEALSSRTYQDVQRKALQHAYE
                     EAGITAVPTFIIGNERIAGAAAREVFEQVIEKESKQKPAAGLQCDLDGNNC"
     gene            21580..21999
                     /locus_tag="DI291_RS01370"
                     /old_locus_tag="DI291_01355"
     CDS             21580..21999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003178471.1"
                     /locus_tag="DI291_RS01370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01355"
                     /product="hypothetical protein"
                     /protein_id="WP_128823291.1"
                     /transl_table=11
                     /translation="MTLHHFIAADQELPLGSFLDQTEEGLISIDELDQGYEMIKTKFSK
                     PFVYEATGCLHRPGNGIRALFSYINSNIADGEDIEVYSCWDGEEDREKDDRLDFFIDRK
                     ALQLGKHVKLDKKKYMDGISDMFYFEERQLVKIRK"
     gene            22247..23386
                     /locus_tag="DI291_RS01375"
                     /old_locus_tag="DI291_01365"
     CDS             22247..23386
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006639994.1"
                     /locus_tag="DI291_RS01375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DI291_01365"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_128823286.1"
                     /transl_table=11
                     /translation="MNDLFDEIRDESINIGGIDGYKFGSLKEILRNKRFVFLGESSHCV
                     KEYIEAKASLIKYLHQELGFRILAFESELGDCSMGNYLSEELSAKENMSGSIGKVWQNE
                     FMLDLFEYMKETQQRQPLHLTGVDVQQSMDKHFSSYMRSHLTGDLRKTFVTFDTRTNEM
                     LDKDYMLKRRFRKTVEEIERIGQGLIRELEKQTFPSAMLRDVVLQTMKNRLNYFKANFT
                     KGFSKLFEYRDELMAKNLEFLSQHVYPDEKFIIWAHNLHIKKQSSVNRFSPYRSFVENL
                     PEFMKEDSFVIGLYAGEGRMGDNQGGDHPIKKVNKKHMEWLLSNSPHPNFFIPCASKWG
                     EKKWKAFEGGGLRISFKPVQQYDGVLFFKKVTPAVVNVE"
     misc_feature    complement(23523..23538)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.25"
                     /tool="antismash"
     gene            23583..23720
                     /locus_tag="DI291_RS01380"
                     /old_locus_tag="DI291_01370"
     CDS             23583..23720
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DI291_RS01380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DI291_01370"
                     /product="hypothetical protein"
                     /protein_id="WP_179289535.1"
                     /transl_table=11
                     /translation="MDVLTFGKVVYQDIHEKICSADEEGNPVPEMPEMVVEEKYEELQR
                     "
ORIGIN
        1 agatgtaaag agaacgacga caatatactt tgaactgaca atttcctttc gtgtataagg
       61 caaagaattg agaagcatat gtatagaaga cttttcatct attgacatgg tattcataaa
      121 aatagcaata ctaaatgcaa ttccaaccca gatgggggaa gcatctaatg ttaaataaac
      181 acataacccc aaaaataaaa ctgccaatgt ttttttctgc aagacaatgt ccttacgtat
      241 taagttgaac atgctcttta gctcctttct tcgtataaaa cataatatct tccagagtcg
      301 gtttttcaat taacaccata tccccaaaaa tgttttctgt tcgtgattta ttcgcagtca
      361 atgcttcaaa tccatgagtt gattttcgaa ccgctataaa ctcctgttcg gtttcccggt
      421 ccaacaactc catgccgcct tttacaattg catattgttc ttcaatctcg taaaagtcct
      481 ttgtaaagat atgctctcct ttatgaatga acgtgatata atctgcaatc ttatctaaat
      541 cagttgttat atgagttgaa aaaaagatcg tcttatcccc atcttgcatg agctgatgca
      601 agatttccaa cagctcacgg cggaaaatcg ggtccagtcc ggccgtcggt tcatccataa
      661 taattagttc cgcatgatgg gacaaagcga cggctaatga tgctttcatc atcatccctt
      721 ttgagaacgt cttgattttt ttagtgagcg gcaagttaaa tgtgttcaca taatcattga
      781 atacttgttc atcccaattg acataggatc ttttcacaat atctttcatt tcagtcaatg
      841 ttaaatgttc ataaaatatg ttcgaatcaa atacaaagcc aattcgttgt ttgatttctt
      901 tctcatgctc cttgtaattc aagccaaata ccgtaatcgt tccgctgtca ggctgcaata
      961 agttcatgat cagtttaatc gttgtcgatt tccccacgcc atttccgccg ataaatccgg
     1021 tgacaaaacc tttttttaca ttcattgaaa agtcctttag ttgaaaacca tcgaacgatt
     1081 tatgaacatg ccggagttca attacattgt ccatcattct tcctcctgat ataaaatggt
     1141 aagcaaatct tttaattctg taaggggaac gccaatgtct ttgctgtttt ttatcgctgc
     1201 tgtcaactgc tcttcaattg ctttcatttt tccttctttc atcatttcgt tattctgatc
     1261 tgatacaaaa gagcctttcc cgactacgga ataaatgaag gcattcttct caagttcttc
     1321 ataggcgcgc tttgacgtaa taaggctgac atttagatct tttgccaatt ggcgcataga
     1381 aggcagcggc tgtccaggct tcaattcatc ggcaagaata tgatccttaa tttgggtgta
     1441 aatttgttca taaatgggtt gctttgaacg attcgaaatt ataattttca tttcaaaacc
     1501 tcttttattt atacacaata tatacaatat gtacaatata cacaaaaatt gcctgaatgg
     1561 caacgatttt ttgtactgaa attttcttga tactctactc acgtcacctt ttacacttat
     1621 attgaagaat agataggaaa ggtgactaaa atggatgaag agccatcaaa aaaagcaatc
     1681 ttttcagtac aattaatgct tggaatttca cttattcttg gtgttatacc tccccttatt
     1741 atgtttttaa tttcaagaaa gaaagactta tattacggtg aatcaagtcg caaagcactt
     1801 aactttcatt tgacgatttt cccattgttt gtaattggta gttttctgcc ttcatgggtt
     1861 aagtacgtta tattggctat agaaacatta ataatcatgt atgctattat tcgaatagct
     1921 tttcaaaaac catattatta tccagccatt ccttacatta aaagtaaaga tgaaaatata
     1981 gaaaagaggt attcgcatgt caaataatat gttgacaatc ggacaattgg ctaaacgaac
     2041 aggagtttct ataagaacac ttaggtatta cgataaaatt ggtttgctaa taccaaccga
     2101 ctacaaagaa ggaggacacc gactttatag ccttgatgaa ctctcacgtt tacaacaaat
     2161 acaatctctt aaattcatag gcttttcact taaagacatc gcagatttat taaaatcgca
     2221 atttatagaa gaacagcaac ttagctattc aatttcattc aaaaaaagag aacttatttc
     2281 agaacaagaa agaattcgtc aaacgattga tcagttggat catatgaaaa ctattatctc
     2341 agggtatgaa aaggtagata taaaattatt cagctttatt attcactcta ttctttttga
     2401 agaggaaaat tttaatgaat atagtcaagc taaaggttct attcacaatt ttagaagcag
     2461 tgaaagagct aatttagata aagagtactt ttcattgttt atggatttga aggaacttat
     2521 agcaaacgaa acaaatcctg aatccgatga agcattaaaa tttatcaaac agttggtaga
     2581 tatttctaac agaacgttat taaagattga tacagcagaa atagaatcaa cggttcaata
     2641 taatgaacct aatatactca atcccttcac ggaagaagaa agagcctttc ttaaaaatgc
     2701 ttttgcttat atgtcaaagt tacaagaatg attaattgaa aaagagtaca cccaatggct
     2761 aaagaaaaaa attggcgctc ccactttctg tgtataaagc ttatttacgg aggttttagt
     2821 tttggttcaa gaaattttcc aaagggtaga agaagtcaat attatttatc aatttatagc
     2881 agtatttata attggatttg tgcctttcct tgaggctttc gtagctgtac caatcggaat
     2941 acttttaggc ctaccattta ttctcgtagt tttagtgggg gctaccgcta actggctgtc
     3001 tgttatggct gtaatagtat tttcttcttt tgtgagatct tggttttcca aaaaagaaaa
     3061 gaataacact gatcattaca ttaacagacg ttttcaaaaa gcaaagtcat acttcaataa
     3121 gtacggagtt cccgggatct cacttttggg tcctataata ggaacaaatc acattggagc
     3181 attggtatgt ataatagcga aagcaaataa aaaaaggatc atcgtttggc aaactgtcag
     3241 tatagttatg tgggctgcgg gaactggagt tctgttaatt ttcggagttg atatctacaa
     3301 taatataaag aactagaata tactcaatac accaaatttt ataattctcg atttggaaga
     3361 gggtatcgct ttttgttaga catattatct tatccttcac tccgtccaaa gtgtggtgct
     3421 attgcaaact tatataagta tggcaactaa caattatttt tcgatctacc aacgtatgcg
     3481 tgttggtatt catgtcaaac gccaacggta aaaaggtagg gaatgtgtcg ttcaggaagt
     3541 aaaaattacc gttgtatcat cacatgttat gagtgagttt ataaagaaat atatgttgct
     3601 gtcttttcca aaaagcaatg gtggaagttt ttttaatcct ctttcacaat atttcaatta
     3661 cccgaagaaa aaataaacgg gcatataaca tattgacaat ttgcgatatg aagatataat
     3721 gattggtatg gaacctattg aagttttcaa agctttatca aatgaatcaa ggctgcaaat
     3781 tttgcaatgg ctgaaggagc ctgatcgtca ttttgaaccc catgaaggga ttgatatgaa
     3841 cacaatcggg gtatgtgtca gccaaatcac agacaaattg aaaatgacgc aatcaacggc
     3901 ttctcaatat ctcgctattc ttttaagagc cggcttgatt aaggcggaac gaatcggaaa
     3961 gtatacgtac tacaaaagag acgaagaggc catcagaaag cttgctgact ttcttaaaac
     4021 agagatatga gcattcaaaa aataaacatc tctagatgat gtttattttt acaccataca
     4081 tatcgacata ttccgatgtg tttatttttt gatttacata tcgttatttc gtgatatgta
     4141 aatgtataaa acgaagaagg agcgaacgat gatgtttagt gcttggaaaa tttatatttt
     4201 agcgatcatc agttttttgg tagggacctc agagtacatt atttccggga ttttggatca
     4261 gatcgcccaa acactcggaa taactttagc tgccgcgggc cagctgatta cgatcttttc
     4321 acttgtgtat gcagttttca caccggttct catggcgttg acggcaagta tggataggcg
     4381 caagttaatg atgtatgctc tcgctttgtt tgtgatcgga aatattctgg cctttaccct
     4441 gcctggctat ggttggtttg ttgcagcgcg ggtcattatg gcattggggg caggcatggt
     4501 tgtggtcacg gcattaacga ttgccgccaa aatcgctccg gcgggtaagc agggcagtgc
     4561 aattgctaca gtggtcatgg ggtttaccgc ttctctgatc ataggtgttc cactcggaag
     4621 aatgacggca gaagcattag gctggaagtc tgtatttgga ggaattgctt tactgggatt
     4681 catcgcaatg attgttatat tcttaatctt gccgcatacc gaaggcgata agcctgttcc
     4741 tttgcttcaa cagctttctc ttttaaagaa ccggaaagta gcaatggggt tatcaatcac
     4801 ttttttctgg ctcggagggt attccgttgc atatacttat ctgtctcctt accttctgac
     4861 cgtttcaggg ataagcggca atttgcttag cggctttttg cttatatttg gaatcgccag
     4921 cttggttgga tcgaagtttg gcggatatag caccgataaa tggggcgttc cttttacact
     4981 cgttggcggg atggcgctgc atatcatcgc actgatttta ctgtcgcttg tcacccattc
     5041 ctatgtcgga gtactgttga ttctcatatt atggtcgttt gccgcatggt ctaccggccc
     5101 gacacagcaa tatcacttag cgacgctcga accggaattg tcaggtgtat tgctcggcat
     5161 caatcaatcg atgatgcaat tcgccatggc cgtaggtgca ggcatcggag gagtttttgt
     5221 ggaaaaaata tcgctcgctt ctattacatg gtttggggca ttggaggtta cgattgcgat
     5281 tgtcgctgtt ttggtgactt tcagttcgca ttacaaacgg aaagcaggac ctgtaagaga
     5341 aatcagctca taatacgttg ccttgattgg tgttgaagat tcaatgggtt cattcctcat
     5401 atcttacttg tttttttcga agtctggcag gtagtgttga gccgaaaaat ctaacacccg
     5461 cccgttgtaa aacgagcggg tgttttttat ttagtccgct aaaatccgca aataagccct
     5521 ccaagggccg acatcatcct gataccgttt cgccagcact cttgcaattt gcgagatgtg
     5581 agtaaggtcg tgggcaaccc atgtcgagat ctgttctctc agtttgacga ttccaaactc
     5641 agggtgcatc cccgtttgtt cgaagtcggt ttcaggatca atgatctgct gtaatgtttt
     5701 cagattcgcc cgtctgatat ctgcaaactc gttaagcaac tgttccatcg tttttccgtc
     5761 gttttgattc aactggctga agcggtcgaa cggcggaaaa ggttccgttg ctccttttgt
     5821 cacgatcaat ttgatgcgcg gtaaccaatt gtttttttct ccttcaatca gatggccgac
     5881 gacatcaaag gcgttccacg tgtcttcgcc ttcattgcag ctgatccagg gacttgataa
     5941 tccggtcagc agctgactca gcgtttgtgg tgtgcgctcc aggatttcga ttgcttcctc
     6001 gagttgaaag ttcatgtggg tgacctcctt tgcaatttga gataaaagga tgagatagga
     6061 ctgacgtgtt ttacatttat tttaattgaa tagttggaag tattcaccca atcaagaaac
     6121 tctaaacagg ctaaaatact ttcatttata tttttataaa cctgagtttt aaagacttcc
     6181 catgggtgga catccaggtt cgatcttatt tggatagctt ctttatcttt aaaacacttt
     6241 atttctgtaa atgattcgac agaagccatg aacatccata taggataata accgacatgc
     6301 cgacgatcag atacaacgga gtattttgta aggttagaag cttgtgaatg aactctctaa
     6361 tttgatcgtt caagttttgg ataacaaaat taacttacgt tgaagtacca atagcggatg
     6421 ttttagatga agttaatgga attggtgctt taacatctta tagtaggcct aaaaatagat
     6481 ttgctcaaga tactccggta acaactgaag aacataacct tctaatttga tcgttcaagt
     6541 tttggataac aaaattcagg gtgctcctcc gcttgttcga aatcagtctc tttatcaatg
     6601 acatgccgta aattcttcag gttctgacgg cggagttcca caaactcgct taataattgt
     6661 tcaataggtt ttccagcatt ttgctgcatc tgatcgatgc ggttgaatgg cggaatagct
     6721 ttggtttccc cttttgtcat aattatttca atccgcggga tatttttttc tccttcaatc
     6781 aggtgaccga caacatcaaa ggtattcaaa gtgtcttcgc cttcattgca gctgatccaa
     6841 tcagtcgata atccggtcag caaataattc agcatttttg gcgtgcgttc caagatttct
     6901 atattaaaaa ttcatatttg tgtatccaga taatgaagtg gggaattatt taatgtgata
     6961 ttacattttg ttttgattca ttggtttagt tacggctgat gctttatgtg tagaagagat
     7021 gatgaattta caaattcctt taaataaaaa ctcataactt tgatggattc aaagacagca
     7081 tacccttgaa aattaaaact ataccttcgg taacgtcaaa gaatgacagc agaaattaac
     7141 ctgcatacta gtaacacttt accatcactg aggagcaagt tctcgcctag tatgaaataa
     7201 tctgagagta ataaagttgt atccaaaaac ctcattgccc ttttgctttt gatcgaaata
     7261 aggaaagagt gtttttgata tgagcataaa atattagata cctggtatgg aaaataaacc
     7321 attaaatggg cgaaatatca aaaaaatata aaaaattgat aaaatcttga tattttttta
     7381 atattatcga aattgcaaaa ccaatatcat atagaaaatc cggttcaaaa ggtttaattg
     7441 agctttatgt acttctgaaa atatggttct tgacaggagg tgactgataa tgccaaagtt
     7501 tgatgatttc gacttaaatg tgaaacaagc aagtgaaaaa gatgtggtta agccagaggt
     7561 tggaagcaga tatttatgca ccccaggatc ttgttggaaa tgggtttgct tcacaacgac
     7621 tgcttaaaga gttaaagtga ggtaattttc aatcaacgtt ataggaggga gtacatagtt
     7681 tttgagacac cctttagatc tacatcatta attaaaccat tggaagaata tgagataaag
     7741 gttttgcaaa ttatctaata gagatttttt aaattgaaaa atttagaaag ggagagattg
     7801 aaattgccaa aatttgatga ttttgattta aacgtaaaac aagcaagtga aaaagatgta
     7861 gtcaaaccgg aagtcggaag tagatattta tgtaccccag gatcttgttg gaagtgggtt
     7921 tgcttcacaa caactgcgta atatattgtt ctaattaaaa gctgaattgt tcgtcttagg
     7981 gctttagcgc ttaactgcta gcctaagaaa taataggtta agtgctagag tccttttaat
     8041 ctatacataa ttttgggatg aaaggaactg catacagaaa aatgatgagt cttaaaattt
     8101 gtataataaa ttgctaacaa aaaaaataaa acggaatgat aataatgcaa agtattaaga
     8161 agaatctaac gcttttgtgc aagacgatta agatgatttt taatataact ggtagaaatt
     8221 tttattttgt agtaatcctt acaattggaa cttctttgac ttcagtcgta tctgtcttat
     8281 tgtttcaaca gctattgaat gcaattgagt taaaaaagag cttgcttgaa gaaatatgta
     8341 ttatgttatt tatctatttg ggatttaatt tgttttctga gtggttgaat aatatatcgt
     8401 cttattttaa tgataagttg cggcttctac ttgaatataa aataaacttt ctgcttatcg
     8461 aaaaaagtag cttgctctca atgagggatt ttgagaattc agatatatat aataaactta
     8521 cacgcttgga aaatgaagtt ggatataggc cctttcaaac ttttcaggcc ttgttgggaa
     8581 ttatttcagc atgtgtaact atcatatctt catcgattat tttgctatta tggaaaccat
     8641 acctaataat aatcctcttt ttactcccgt ttttatcttt gttttattac ttaaaaattg
     8701 cacaagagaa ctttaagatt cactttgaaa gaagtaattc agaaagagaa gcctggtaca
     8761 tcagctattt gatgacgcac gatttttctt ttaaagaaat aagaatgtat ggtttgagaa
     8821 actatttttt aaaccggttt tggaggctta aacaacgctt tagagaccaa gataatggta
     8881 ttaataaaaa gaaaatgata tatggattta tttttaatac gattcaagat atttgcatgg
     8941 gtgttgttgt tttcattgct gtaattagtg catttacagg aaaattatta ataggtaatg
     9001 tagcaactta tattaaatcg attagtatgg ttcaatctaa tagtcaatca ttaataaata
     9061 gcatttatca gttgtatgag agtaacttat acatggaact actagatgag tttttaaatc
     9121 ttgaaataga aacagtagat tctaataaaa ttaagataaa ttctattgat gagattgaat
     9181 ttagaaatgt ttcattcagt tatgatggaa gtaaaaattc cttagagaat gtatcttttc
     9241 gtatcaaaaa gggagattta cttgcgatta tcggcgtcaa tggatcagga aaaagtacca
     9301 tactcaaatt aatctgcgga ttatacacta attatagtgg tgaaatttta attaatggta
     9361 tagagcttaa aagaattgac catgaatctt atagaaaatg tatatctgtc ctctttcaag
     9421 attatttaaa gtatgaattt acacttggag acaatgtttc tgtgggggat acttcaaata
     9481 tgaatgattc ggaaaaaata aataaaacat tggaaatggc aaatgtcact tttttaaagg
     9541 atgggaataa atcatatcaa ttaaactctc aactgggcaa ttggtttgat gatggaacac
     9601 aattatcagg aggtcaatgg cagaagatag caattgcaag atcttactat agggaagcat
     9661 ctttattttt gttagatgaa ccaagttcag ccctagatgc aatttccgag aaacatatat
     9721 tcgaaagttt ctttaaattg gctactaatg aaattagcat ctttatcact cataaggtag
     9781 aaattgcaaa acatgcaggg gaaattttgg tgattaataa tggtgcagtc gaagggattg
     9841 gaaatcattc ggacctcatc aggaactgtg atgtgtaccg cagtttatat gaaaaagatc
     9901 aaattgatag caactcttct atggttagta attaatgagt gtaagcttca gttcaagaag
     9961 gctgtttttt aaaggcttta attggggagg ttagatcaat atgttggata gcataagaac
    10021 caaaactagt attcgggata ttgcttcacg aattgccgac atatcgtacg tagaaacgga
    10081 gtcgaaaaga aatgaactaa attatcgtaa tgcaggagag attacacaaa cactgtctcc
    10141 aatgactctt agccatggtt atccttcttt atgcatattg tttagtaatt tgggagtaac
    10201 tgataatgag aattgctgga tagagtattc caataggtat gtccagcaga ttgttaattt
    10261 aataaatgag agaggaatat ttggagcttc attattttca gggactgcgg gaattgcatt
    10321 ttcgataaga atagctagta tgcgggggct ttactattct aaattacaaa agtctttaga
    10381 tcgttttttg tacgaccaac tagatgaaat actaaccaat ttaaacttta agacgaacta
    10441 tgagatgttt gactatgatg tcatggaagg attagcagga atcgcaaatt atcttttcat
    10501 catagaaaat gatccaacaa gtgaaaagta tttaaaaaaa atcttgacct attttgtttc
    10561 tttatctggt tataaggaat tttcaggtga aaaaataccc aattggcaca taaaaaatga
    10621 gtttttattt tcagatagtg aaaaagaaac ctataagaac ggaatattga atgtaggttt
    10681 gtcacatgga attcctggcc ctttaattat tttaagtaag gcttataaaa gagggattct
    10741 tgtaaaaggg catttggaag ctataaaaag aatagcctat gatttagtaa aactcaaaaa
    10801 ccagtatgac aataattggg gggggatgat agacgtacaa caatatttta accaagaatg
    10861 tccacttcgt ctaccgacac gttcagcttg gtgctatgga acacctggaa cagctttttc
    10921 gttattgact gccgctgaag cattaaatga tagggaactt tccgagattg caaaacaagc
    10981 catgaaggat ctaatcggaa atgaacagaa aatcttttcg ccttcctttt gtcatggtta
    11041 tgctggtata tcgtatcttt ataaaagatt ttatgaaaaa acgggtgtgc aggagtttga
    11101 taatgaatca aagcgcttaa aatcaaagac ccaagaattt tttgattttt taaatccctt
    11161 cggttattgc gatattgaaa ttaaggataa ctataaattg aaacttaatt caatagggct
    11221 tttacaaggt gttgcgggaa tattgctttc ccttctatct tttgaagaga acagtccttc
    11281 gatatggaat gttgcctttt tattagatga ctaatttgaa gaaaggaaag agtattatga
    11341 caagttattt taaacctata agtaaatata tgcttagagt accgttacat ccgaactcat
    11401 taattgaaag attttatgac atcgaaaaaa gtataggggc gataaagaac gatacatttt
    11461 tatgcgaaca gcttttggta gcaagcgaaa atatttataa aacgttatta aataaagatt
    11521 tctctacatt atctaagaaa aagaagagaa acctgattgc ttccctggga aactacatta
    11581 atagagctgc gactagaacc actccttttg gtttatttac aggagttgga atactcgatc
    11641 tgaagaagac tgaggtgtcc aagccttcaa aaatcaatat taaaaagaac agtcgtattg
    11701 atgcagaatg gttatttaaa cttatcaaaa agatagaagt agagcatttt tatgacttaa
    11761 agtttaaaat gaacacagca tcttatcgta aaggtaatcg cctacatatt ccttataact
    11821 tggatggaaa gacagtagaa atcaatgttc attacagtaa gcccttaatg cttattgaga
    11881 agctatgtat aaaagaacat gtaagtttca aaaaaatggt tcgggcatta caagaaagat
    11941 atccgaaaag ggatgttgac gatcttgtag cctatgtaaa aaccttgatt gaaaaagaat
    12001 ttattatttc tgaaataaga cctccccttt gtaatacgaa tcttctaact tacacaatta
    12061 ataaattgtc aaaaatacct tttttatacg agaaatacgg taaaccactc agtgaagtgg
    12121 atgtgctgat tggaaagtat aatgatgctc ctatcggcca gggaactaaa aattatttaa
    12181 caatccaaga aaaattaagg tgcatgcatt cttttacaaa tgaaaaacat ttacaagtag
    12241 atacaaaatt agatttagaa ggagtttata taaatgagag agatatcaag aatatcaata
    12301 aatgtattac attattaatg aaatttgctt ctgaaattga agactctaaa agctataaaa
    12361 atatttttga agaatatcgc ttaaagttta ttgagaagtt tggaacttac gttgaagtac
    12421 caatagcgga tgttttagat gaagttaatg gaattggtgc tttaacatct tatagtaggc
    12481 ctaaaaatag atttgctcaa gatactccgg taacaactga agaacataac ctttggaaaa
    12541 gatattttat gaataagtat ttagctgctg ttgaaaataa gcatcctatt atcataacag
    12601 atgaagaaat taacaagtta aatatgaagg tagacgagaa aaggttaccg agttctctcg
    12661 aattaaattt tatcataaga aaaaataata acggagaaaa tcttctttat ttgggaccca
    12721 atataggttc atctgctgct gggaaaacat ttggaagatt tagttatttg ggcgatgaat
    12781 tttctgaagt gttggacgaa gtaggcagag agttaaaaga aagtgaaatc gatcaagtgg
    12841 agctgtgttt tgttccatca aacattagaa tggcgaatgt tacccgtatc aatacaccga
    12901 gagagtataa cctttcaatg tttactaatt catataatcc gaacaatgaa ttaacattag
    12961 ctgatattct tgttggatgt gacaatgaaa agttttattt gaaaaataaa cggaatggaa
    13021 gattgctgaa tatatcagga atgaatatgc tcaatctgag ctcttcaagc aatatcattc
    13081 gattattgag cgatatctcc ttaaatcagt atttagaatg gagtaatact ccatggggtg
    13141 tatattataa agaatttatt catataccag aaattcgata tgaaaatatt attctctcaa
    13201 atgagaaatg gagtttacaa aatctgcgag ggcagtttga aagaacccca aaaattgaag
    13261 aatttatggc ggagttccaa aagttcagaa gagtttattc agtcccggat aatgtttatt
    13321 ttcaatttgc tgataatcga attttattgg atttatcaag aaaaactaac ctcaacttgt
    13381 tgtataagaa tttattcaag tttccaagta ctgctttaga gaaagcagag gctggaaacc
    13441 ccgctattac cttaggtgag gaatatttct cagcagaggc ggtaattcct tttgttctaa
    13501 aagaggaata cagagacaat aagagtaaga aagaattctt taatggaagt atatatcagc
    13561 aggttagcta tcctcctttt aaagaatggc tgtttttaaa actctatggc cctgaagacc
    13621 gccaagatga attaatagaa tacatgaaat acttcatttc aacacaactg gataggagtg
    13681 tttatgataa gtttttttat atgagataca atgacccaaa acctcatata agattgaggt
    13741 ttcgttcaat agaaccaaac aatcttcaga ttatttacga caagctgagt gagtacataa
    13801 ttgaattaca aaaaatgagc atcatttatg aagtaaccat caatacttat ttccctgaaa
    13861 tcaacaggta tggtgggtcg gtgctgataa aggatgctga aaatttattc taccatgata
    13921 gcttagttgt gatggaaatt cttaaagtca tgaaacaaaa tagtctgagc caagaacaag
    13981 ttggagtgat ttccttactt cactacttga ttgactttgg attatctttt gaaaatcaat
    14041 taaattactt gcagctaaac ttaaaaaaca gtgacattca taaaaaggaa ttcaaacaag
    14101 aaaagtttga tttcatcaat gaactagatt cttataacaa ttgggaaaag gctaaaaaaa
    14161 gagaagacct aaaacaaatt attgatatcc tagaatatag gagcaaaagt attaatgtct
    14221 atagagaaca tattaacaga agcaataaac atacgagtga tttcattaac attatgggga
    14281 gcatcattca cttgcatttt aataggttgt ttgagattga ccgcgatttc gaaaataaac
    14341 tatatgttta cgcataccaa acattatatg gccagagagt tcgaagaaaa atgcttcatt
    14401 tacaggaact ttaaaaaaca tcttaaacag atggttgaac agattaactg atcaatcatc
    14461 tgtttttttc gatattgatg gagtcttgat tttttattgc taaactccat ttataaagac
    14521 gaaaaggagt tatttgaaga tgaataatga gtatatcttg caaacgaggc acttaaccaa
    14581 aaaatacaaa aaatcgacca ttttaaacgg tgtatcaatt aatgtaagaa agaacactgt
    14641 ttacggcctt ttgggtccca acggggcagg taagtcaacg acgctaaaaa taatatccgg
    14701 tttgctcaaa caaacatcag gagaggtaat ttttaatgga aatcagtgga caaggaaaga
    14761 tttgatttat atcggatctt taattgaaaa tgctccgctt tatgggaatt taactgctat
    14821 agaaaatctt gaggtgataa atacgattct tggcctgcca aaagagcgaa ttcaggaggt
    14881 tcttcaagtt gttgggttaa caaatacggg aagtaaaaaa gtgatgaatt tttctatggg
    14941 aatgaaacaa cgacttggca ttgcccttgc cattttgaat cgtcccaagc tattaatttt
    15001 agatgagcct actaatggat tggatcctat tgggattcaa gaattaagag aattgatggc
    15061 ttcatttccg aagcagggaa tgaccgttct tttatccagc cacttgttat cggaagttga
    15121 acatttagct gatgatatcg gcattatcag caatggaata ctcggttatg aaggtaaata
    15181 tcattcatat gataacttag aaaatctatt tacagatgtt gtacgaaagc atagagccca
    15241 ataggaggtt accgaatgta tttatattta aaatcagaaa tgataaaaac aaaaagaaca
    15301 atgattagaa aaatgttgtt ggtgataccc ctaatatgtt ccattcttgc actaggtttt
    15361 aattttctag gcggcccgga tatcgtaagg ctgagtgtag aaacgatcat taatcattgg
    15421 ggaatattat ggctatccgt gttcgtagcc ctttccactg ggcttttaaa taatctcgaa
    15481 aaaaaatcga cgaattttaa aacgattatt ggcttaccaa tagatcttca aaaaaaggaa
    15541 ataagcagag ttttatttac aactggatta atggggctag ggtctcttct gttaataatt
    15601 tttataatcc taacaagttt gctggttaat acaagtccat atttggtttc actttcttct
    15661 tgtattttag cggttacctt aatgtttata gcttcactat ggcagatccc gttttgcttg
    15721 tggctttcta gaaaaacgaa tctttttatc accttactgt tgaatagcat gcttaattta
    15781 aatttaggtt cagtttttgc tcctacggga gattggtggt ttgttccata cagctggcat
    15841 ttaagagtgc aaatgccttt aacgaagcta cactctaatg gaatcccttt gccgcaaaat
    15901 gatgaacttc tgagctattc agttattccg actgctcttg ttttaagcct tacatttttt
    15961 ttcatactga cattgattac tgttaggtct tttaataaac ttgaggtgaa ataatgctgc
    16021 aattttatag atgttttctt ggagaatgta aaaaaagaaa gcgaagtata ttttcattat
    16081 tacacttaag cattccgctc gttttatctg gtgttttggt gatgtacttc ttattcagga
    16141 atgtacccgt aggtccggaa gcaagctata tcattttttt cgaattaata ggagtaggta
    16201 caccggtcat catttcgatt atttgtggtc tggtggccga ttctgaaaac gaggcaggcc
    16261 attttcaaaa tatacttgga ttaattcaga gcagaaccgt ttcattcaca agtcaaacaa
    16321 caatgatgat attctcttat tttgctgcga tgtttttaac gatatcaatc tataccctag
    16381 ctctgaagca cctgattgga gtaggtgaag ttaactttac tctctactat ttaacaggta
    16441 taatttttgc aggaacttcc atctttcaat atttcttcta tcaattcgtt ggttataatt
    16501 atgggatagg aatgtgcagt atatgtgggt ttggaggagt gattatcgca gctctgtgct
    16561 tgaccacaat aggagataaa atctggtggc tcctgccttg ggcttgggca aaccgattcg
    16621 gtgaatatgt aatggattat ttgaaaatga caggtgtaaa accggttgga aattctacac
    16681 ttgtaatggg aggttattct tttttaatta tgacaacagg aataattctt ctaagtatcg
    16741 tttggataaa taggtggtcc ggaaaaaaaa caaacgatta aagggtggtt caatttggcc
    16801 aaaatcttgg cggttgatga tgacgctgca attctaagac tggtcaggaa aatgttgagt
    16861 ataaaaaaac atgaggttac aactttgcaa agtattaaag atatcacgat agaggagtta
    16921 aataaatata atctcatttt attagatgtc atgatgccag atgaagatgg atttaaaata
    16981 tgtgagaaga ttagatcttt aattgatata ccgatcatct ttatgactgc caaaagtgat
    17041 gaatcttcaa taattaaagg tttatccatt ggcggagatg attatattgt aaagccattc
    17101 agcattcatg aagtgaatgc acgtattgag gcccatttaa ggcgggaagc aaggccgaaa
    17161 aaggatacaa aaagtgtatt tatcgatggt gacatcctta ttgatttgga agcaaaaaaa
    17221 gtaatggtga aaggggagga agtaaacttt actaaaactc aatacaaaat ttgtgaactg
    17281 ctcgcattac acaaggggaa aatcttttcc aaagaagata tttatgagtc tgtctattca
    17341 atagaaagcg attctcaaat ttcaacggtt gttgaacata tcagagtgat aaggaaaaaa
    17401 attgcccagt tcaatttagc ccctatcagt acggtctggg gtgtagggta tatatgggaa
    17461 taaagaatac gttatcggtt tattttatta aatggattac aaaattaggt tttgcaggtt
    17521 tgtttatttt gaccctgaat attggattcg tgacttgggg aattaatcat cattttttcc
    17581 ttccggcaaa tgaaccgata aaaaaagcgg aaaaaataca gagtaaagtt gaaaatgcca
    17641 attatattga tcccagcatc attcctccag aactggatta tactattttt aataagcaaa
    17701 caaacaaaat tgtaaagagt aatatgagtt ccagaaataa acaaagatca atagaagctt
    17761 atctgcatcc tagtaaggat agaatgagct cttttataag atatgacagt cgatatgaaa
    17821 gcattttgat tcattatagc ttgaaaatcc agtttgcaaa tattgaatta agaaaggtat
    17881 ttccgaaccc tggcgtatgg atatcagttt tttcaatttt aatttattgt gtttatttag
    17941 tttggaatat aagaagtttt tctcgaatta ttgtccaaga aaaccaaaag cttatccaag
    18001 tagcccgtaa aataaaagaa agagacttaa atatcgaatt tccgcgagtt cgatttaatg
    18061 agtacaaaga tgtaatgggc gcaatggaga gtttatcgga agcacttgtt aaatccattc
    18121 agaaggaaat tgagattacc aattcaaagt cagaacagat cagttattta atccacgata
    18181 taaaaattcc actgactgtg ataaaaggga atatagaact tttggagaca atgggagatg
    18241 aggatgctaa ggaaaatttt agcgacatta tgaattctat acagcagatt gaaggataca
    18301 ttcaggaagt tatcgatatc aacctggaca acaaacaaga caatacgaat atggaagaag
    18361 tatctgtaac cgatttcttg tgcaagctgg aagccgaagt taaaagcttg ggtaataata
    18421 tcattgtcga agattggaca cataaagagg ctactagcct ttatatagac gtaatcctgc
    18481 ttattcgagc aataaataat attgtattaa acggaataga aagaacgccg ccgcatgaaa
    18541 aagtgcaaat gatcgtcaag caggataaag accgtattca atttgttatc atcgatcaag
    18601 gaccaggttt ttcggaagaa gctctaaaaa aaggtactga gcttttttac actgaaaact
    18661 ttggacggac taataacagc cattatggat taggattaac gtttaccgaa aaggtaatca
    18721 agcagcataa tggaagaatg aagcttagaa ataatgccaa caactctggg gaggtactgg
    18781 tagaattacc gattctatcg agaaagggat aatacaaaag ataagttcat tttaatgact
    18841 aaaagagaat acttgacagt ttttgtgtga aattttaatt ttaaagtgtc ccgaatcctc
    18901 gttcgggaca cccttttata tttttgagac tatgtcagct gccgctcagc aaactcacga
    18961 tacagcgcat gcgaagcaat cagctcgtgg tgccgccccc gccctgtgat ctcgcctttt
    19021 tcgataaata taatttggtc cgcgttcacg attgtcgata gccggtgggc gatgacgaag
    19081 gtggtacggc cttccatgag gcgggcaagc gcctgctgga cgatggcttc tgattggctg
    19141 tcgaggctgg ctgtcgcttc gtccatcatt aaaatttttg ggtcacgcag aaaggcgcga
    19201 gcgatggcga tccgctgtct ttgtccgccg gacagcttga cgccgcgttc gccgacttcc
    19261 gtatcaagct gctctggaaa ttgtttaata aatgtgtcgg cataagccat ttccgcgact
    19321 ttccacagtt ctggatcgtc aatgctgtcg gcgtagtcca agccatagca taagttctca
    19381 cggatggtgc cggacatcat cgggctgtct tgagatacgt agccgatctg gctgcgccac
    19441 gatttcatcg acagcttgtt gaccggtgtt tccccgatat taatgacccc tgagtccggt
    19501 tcgtaaaatc gttccaagag gccgaacatc gtcgtttttc cgccgccgct cggaccgaca
    19561 aatgcaatca tctgcccggg atcgacgtca aaagatacct cccgcaagac aggctcgtca
    19621 tcgccataag agaaagatac attctcgacg cgtatcggca gattggagat gtccatttca
    19681 agtccttcct ggccctcttc ctcttcagta tgcaaaatct cgatgatccg ctctgttgcc
    19741 ccttttgctt tttgcagctg agtgaaaaac attgtgaacg atgtgatcgg gaagatgatt
    19801 tgaaacagat aaagcaaaaa ggcgatcagt gaacctgccg acatcgtccc ctcagagacg
    19861 cggatgccgc cgtagccgat gatggcgacg atcacaatca taatgacaag gtgcataaac
    19921 ggggagacaa gcgcaaatat acgggcttcc ttgagtccgt attgaaagag cttcgaaatg
    19981 cctgatagcc ctttcgtttt ttctgtatgc tcggcgtttg atgctttcat taatctgatt
    20041 tcgcttaatg tctgctggac atgtccggtg aaggaagctg tttcatcctg cagcgttttg
    20101 gagatgcgct gcattttcat gccgagcggg atcatgatga aggtcgtgat cggaacggag
    20161 atcagcatga gcagtgtcat tttccaatcc atgatcagca aaatgatcac cgatccgaca
    20221 atggtgatga tgccggaaac aaactgcgga aaatggtcgg aaatcaagct ttcaataatg
    20281 ccggtgtcat tgacaacacg gctgacggtt tcaccgctcg tcttttcgtc aaagtagcgg
    20341 acaggcaggc gcagcagctt gaaccacata cgctcgcgca gggaagcgac cactttttgc
    20401 ccggcatagg aaagaaaata ggtcgaaaac ccgtcgcaga ccgcttgaac aataaaaacg
    20461 agcgcaagga ttcccgctaa ggccagattg atcgaattga cggaaaagcc gtcaaccatt
    20521 tcccttgtca acagtggaat ggacaggccg accaatgtag tgacgaggct tgcggccaaa
    20581 ccgacggtta aagccagcct gggtacgccg gatgtgagaa tcatggtgaa aaacggtttc
    20641 atgctattgt tgttttctgt tttcatttga taaactcctt atcgatataa tgtcaaagaa
    20701 gtggatggcg caagctgtaa ctcatcatat tacgatataa acagcagaaa gttcccgatc
    20761 attgccgatt ttaacttcat gctaaaaaga ttgacaggag agataattgt aactattatt
    20821 gttacataaa gttgattgaa tgatatgaaa ggaagaaaaa catgacgata aatattaaag
    20881 tatattccga ttatgtctgt ccattctgtt ttctcggaaa agaccaattc gaaaaagcga
    20941 tcgaaggcaa agatgtggaa gtcgagtggc tgccattcga actgaggccg cgcccatcgg
    21001 agcagcttga tccgttaaat gatccatcaa aattggcaat gtgggacggc gccattaagc
    21061 cgcgaatcga ggcttggggc gtcaacatga agctgccaaa cgtctcaccg catccttata
    21121 cagatttggc tcatgaaggc tatcactttg caaaagaaca cggtaaagcg aaagcgtata
    21181 atgaccgggt ttatcaagcg tttttccagg aagatcaaaa tattggcgac atcgaggtat
    21241 taacagcgct ggctaaagaa gccggactgg atgagcaggc ttttaaagaa gctttaagct
    21301 ccagaacata tcaggacgtg cagcggaagg cgctccaaca cgcttacgaa gaagcaggca
    21361 ttacggccgt tccgacattt atcattggca atgaacggat cgccggggcc gctgcgaggg
    21421 aagtgtttga acaggtgatt gagaaagaaa gcaaacaaaa gcctgcagcc ggcttgcagt
    21481 gcgaccttga cggaaataac tgctgagcag gaaaaatgag cgatttgaag aaccctttaa
    21541 tagggttctt ttttataccg gaaagaagag ggaagacagt tgacactcca tcattttatt
    21601 gcagccgatc aggagcttcc gctggggagt ttcctggatc aaacagaaga aggtttgatt
    21661 agcatcgatg agcttgatca agggtacgaa atgatcaaaa caaaattcag caagccgttt
    21721 gtgtatgagg caaccggctg cttgcataga cccggaaatg gtataagagc gctattcagc
    21781 tatatcaatt caaatattgc cgatggcgaa gatattgaag tttactcttg ctgggacggt
    21841 gaggaagaca gagaaaaaga cgaccgctta gactttttta ttgatcgaaa ggctcttcag
    21901 ctgggcaagc atgtcaagct ggataaaaag aaatatatgg atggaatttc cgacatgttt
    21961 tattttgagg agcggcagct ggtcaagatt cgtaaataaa acatttgctg gcgcagggtt
    22021 ttcacacctt tttccggccg gttcatttag atgttcaatc agtgcacgcg cattgtcata
    22081 gctcacaggc taagtacgat taaggatgca gatctcatat tagtgctaaa agacggagag
    22141 attcaagaga tgggcaacca tttacaattg attcgcaacc aagggtttta caccaaattg
    22201 taccattcaa acaatgacca agcgattgtg ggaggaggct aaaacagtga atgatttatt
    22261 tgatgaaata agagatgagt cgattaatat tggggggatt gatggttaca aattcggctc
    22321 cttaaaagag atattgcgaa ataaaagatt tgtatttctt ggtgaaagca gccattgcgt
    22381 caaagaatat attgaggcga aggcaagctt gatcaaatat ctgcatcagg aattaggatt
    22441 tcgtattctt gctttcgaaa gtgaattggg agattgcagc atgggaaatt atctttcaga
    22501 agaacttagt gccaaagaaa atatgtccgg ttccatcggg aaagtttggc aaaacgaatt
    22561 tatgcttgat ttgtttgagt atatgaagga aactcaacag cggcagcctt tgcatttaac
    22621 aggcgttgat gttcagcaga gcatggataa gcacttttcc tcctacatgc gttcgcattt
    22681 gacaggggat ctcaggaaaa cgtttgtaac atttgatacg cgtacaaatg agatgctcga
    22741 taaagattat atgttaaagc ggcgttttag gaaaacagta gaagaaattg aaagaatagg
    22801 ccaaggactg ataagggagc ttgaaaaaca gactttcccc tctgctatgc ttcgtgatgt
    22861 cgtgttacag acgatgaaaa acagactcaa ttattttaag gcgaatttta caaaaggttt
    22921 ttcaaaattg tttgaatatc gtgatgaatt aatggcgaag aatcttgaat ttttatctca
    22981 gcatgtttat cctgatgaga aatttatcat ttgggctcac aaccttcaca tcaaaaaaca
    23041 aagcagcgtc aatcggtttt caccatatcg atcatttgta gaaaaccttc cggaatttat
    23101 gaaagaggac agttttgtta ttggtcttta cgcgggagaa ggaagaatgg gtgacaacca
    23161 aggaggcgat catcctatca aaaaagttaa caaaaagcac atggagtggc tgctcagcaa
    23221 ttcaccccat cccaattttt ttataccatg tgcttcaaag tggggggaaa aaaagtggaa
    23281 ggcttttgag ggaggaggct tgcgtatttc tttcaagccg gttcaacagt atgacggagt
    23341 tttattcttt aaaaaagtaa ccccagcagt tgttaatgtt gaataggatg ttgacgggtt
    23401 aagcataacc tctaaggtga agatctctgc ttataggaat tttttgttgg gaaaagaact
    23461 ttttcgttat attaaattgc tggtggcggc caaagggagg aaaactgaaa gctgtttttt
    23521 tggttttcaa tggtaaatgg gattattgca tggagtgcac aagtcagacc cagggtaatt
    23581 tcatggacgt attaactttt ggtaaagtcg tttatcagga catccatgaa aagatatgtt
    23641 cggcagatga ggaagggaat cctgttcccg agatgccgga gatggtggtt gaggagaaat
    23701 atgaagaact ccaaaggtaa actggtaacg cgttcacagt ttcttgagag gaagatcttc
    23761 aacaaatcat gataaaggga tggccgaagg cttttttcac agctggatcg ccttgaagac
    23821 gatctgaaag ccattcgtta aaagagggag ggtatattga tgacgacgtt tcctgagcat
    23881 ttcatataac cgcgtaatcg cggacctcct catcaagttt ttctataacc attaaaaaga
    23941 ggaggtttat atacatgcgt acagaacagg aaatcatcga tttggtgctg aaggtcgcac
    24001 gggaggacga ccgcgttaga gcggtcggca tgaacggttc gcggacgaat ccgaatgttc
    24061 cgaaagaccc ttttcgcgat tatgatatgg tctatgttgt aacagatatg cagtcttttc
    24121 ttgatgagcc gggctgggtt gacgtttttg gggagcggat catcatgcag acgccggaag
    24181 cgatggagct gtttccgaat gagcttggca accgcttttc ttatttgatg ttatttactg
    24241 acggcagccg cattgatttg attcttgtgc ctcttgaaga aaagctggaa tactgccggg
    24301 aagacggatt aaccgtgatc ctactcgata aggatcagga tctgcccgtt atcccgccgc
    24361 cgacggatcg ggaatattgg gtgcaaaaac cgtccccgca atgcttcgcc gact
//
