LOCUS       NZ_QGHB01000015        25489 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Lentzea atacamensis strain DSM 45480 Ga0215650_115, whole genome
            shotgun sequence.
ACCESSION   NZ_QGHB01000015
VERSION     NZ_QGHB01000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Lentzea atacamensis
  ORGANISM  Lentzea atacamensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 211570)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 211570)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Expected Final Version            :: No
            Genome Coverage                   :: 90.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003148865.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:35:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,333
            CDSs (total)                      :: 9,254
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 79
            rRNAs                             :: 6, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 6 (5S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 32 of 144
            Pseudo Genes (incomplete)         :: 121 of 144
            Pseudo Genes (internal stop)      :: 2 of 144
            Pseudo Genes (multiple problems)  :: 11 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:50:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 54496
            Orig. end                         :: 79985
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QGHB01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25489
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25489
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25489
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15489](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15489
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            66..818
                     /locus_tag="C8D88_RS38385"
                     /old_locus_tag="C8D88_11552"
     CDS             66..818
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103977.1"
                     /locus_tag="C8D88_RS38385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11552"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_109640928.1"
                     /transl_table=11
                     /translation="MTYTPSTQHTSVPAPRGVPDRHINAVRQATDVLYEVVEELDQAAV
                     RGQSLLPGWTRGHVLTHLARNADALVNLLTWARTGVEHQAYTSRTDRDADIEEGSRRLL
                     QLIKADLDSACLRFDAACRDMPAHAWRSEVIAPSGTTIAASVVPLFRLREVWIHLVDLN
                     CGVGFDDLPAEFVAELLDDAVKQFEGRVDPFSIEVDLPEGGQRIWTVSGPASRSSVSGS
                     ASAVLGWLTGRTDGTGLRGELPELPDWI"
     gene            complement(<866..1825)
                     /locus_tag="C8D88_RS38390"
                     /old_locus_tag="C8D88_11553"
                     /pseudo=""
     CDS             complement(<866..1825)
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013884.5"
                     /locus_tag="C8D88_RS38390"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11553"
                     /product="acyltransferase family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIPAQRHKPRTARRVSWDVLRVVAIGCVLLHHATLTSVSSHPDLG
                     PLPFRFPMSMGASTLMVVSAFFACASLDSGKPGQFLWRRLARLLPAYMAAVLLTYAVQR
                     WIAPEGWSQLDGRDVVYNLLLVNQWFPDVDIVDFAYWTVPVQIAAFIAGAVLVKHMRGK
                     KLRFFLWALIVTPLLLRPLLDHSHTLFVIYNGFALHRAQLFAAGIAIWLWHKHRMSTPH
                     LVALLTATLVAQAIHTTEYGSTLGFAVLLLLVCAAAAGPDWVFFAPVARPVTWLAGISY
                     GVYLVHQQIGTVVMDRMHAVGLRSWWLLAGFLTSAVVLG"
     misc_feature    complement(1901..1917)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.6"
                     /tool="antismash"
     gene            1965..2642
                     /locus_tag="C8D88_RS38395"
                     /old_locus_tag="C8D88_11554"
     CDS             1965..2642
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005448922.1"
                     /locus_tag="C8D88_RS38395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11554"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_109640929.1"
                     /transl_table=11
                     /translation="MDVLENYTGHVEPDGPAARRTLDALTITKISVGPMDNNAYLLVCR
                     STNEALLIDAANDYERLSDLLGHIPNRPRLRTIVTTHQHADHWQALGALAGAHGSNTVA
                     HELDASVLPVPPDVLVDHGDTINVGEVPLSIIHLRGHTPGSIAVLYDDPAGHPHLFTGD
                     SLFPGGPGRTTSPDNFASLMADLEERVFGKLPDDTWFYPGHGDDSTLGVERPKLAEWRA
                     RGW"
     gene            2783..3352
                     /locus_tag="C8D88_RS46365"
     CDS             2783..3352
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025107.5"
                     /locus_tag="C8D88_RS46365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_146231810.1"
                     /transl_table=11
                     /translation="MSIEAIAWALNSAPIPTNRKDSSSLAVVLIGLANHADPFGRNSFP
                     SVATLTRYTRLSERTVRTTLDRLHALRLIKPSDPDILAAHIKRADRRPQGWDLAMCDEV
                     HVSHLAEQDGVQSTRHEVQSTTRRGASTAPDPSLNRPRNRPAPSAPGRRSAASATLVTP
                     IRCRLGSSGSTRTEPARRCARAATQR"
     gene            3572..4198
                     /locus_tag="C8D88_RS38405"
                     /old_locus_tag="C8D88_11555"
     CDS             3572..4198
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022388.5"
                     /locus_tag="C8D88_RS38405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11555"
                     /product="DUF2637 domain-containing protein"
                     /protein_id="WP_146231811.1"
                     /transl_table=11
                     /translation="MNEPTIWIKRTCVVAVAAVAAVAAVVSFDHMRALASDAGEGWKAW
                     ILPISVDGMLVSASLVMLARKRAGQPVGALAWIGLILGLLVSLAANVAAAEPTLVGRLV
                     AAWPPVALGLSYELLLTLIRETSTVHEPADQQVVAAQPVVHEHLVPLPQAPPKRSRKLL
                     QDYLNEAREHLGPDVNVTPAWVREVTSCSRGLSSKIAASLKTGMQ"
     misc_feature    complement(3584..3597)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     gene            4436..6310
                     /locus_tag="C8D88_RS46370"
                     /old_locus_tag="C8D88_11556"
     CDS             4436..6310
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS46370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_11556"
                     /product="hypothetical protein"
                     /protein_id="WP_146231812.1"
                     /transl_table=11
                     /translation="MRDGMLRTRWIMVGLCIGLIFSLYLATIDVGTVRGWWHLIPSVTA
                     IMLAVALAWIGYQPDLKKSALGKPHPKQPRLEDVEAAAQYVKDKYGDDAIRYFQNALLD
                     LASYLVRVDQELSIDGRDLSTTTTLTFRYELHDDRPENSHDENISDEDDSLTKSVDVTK
                     ITKNDRKSILVPIVTARKGHLFDKFAARSSSGAKVNLISQYEIRGLLATAIQALFTQHL
                     TQADGNRASLTPDQEHGLRDVMNDVLINAACFVGNTPSRPDTSFKLVDSRSETLADIDH
                     KLSQWPLLFSKDVRSKITRICRVLTYNYLIVAEMTQPEQGNFIVSYEHMVTSDLMRTKR
                     EELLRARFGLDPVTIDLPVSRAFQADSFHLQIQAPPGQYVFDHHLEELGSRNKMEQDSF
                     ENAQPIRPYMRLYHEEGRSIAHLYVRRQGAHPHTQLSTATSSPHVTAPSFKSVIRFREI
                     PPGSISGIALVSLMTSILIMFFTFARSPFNPTGTFQGAPALILALPAFVAAALGRGVDG
                     RGLARSSLTVSIALGIVVLNSLLSVVFYILNAVNSLPGNVTVTLSFLPQTTLVSTNGLW
                     LTLGLWSTATTIFIYKEKRAQTNYYLNMLTRSAVDNEKKDIQNEREAI"
     misc_feature    4502..4504
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4739..4741
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5261..5263
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5282..5284
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5588..5590
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5846..5848
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6322..6972
                     /locus_tag="C8D88_RS38410"
                     /old_locus_tag="C8D88_11557"
     CDS             6322..6972
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS38410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_11557"
                     /product="hypothetical protein"
                     /protein_id="WP_146231813.1"
                     /transl_table=11
                     /translation="MSAEQFHWLPRFKRRHQENQQREATPQAPPDPDWSEGRAVFRMPE
                     TTDEELDLMRAIHSEDERKMFNVALTEVLEELGDPGMRQERLQRARQFDQKNARRILAR
                     AANAYRSKRLTQQQFKDEYLRKSILFAPIPDGSQLPIVVEGEAGYPIAPVFSSLQALQD
                     EFGPDQEYIEGIGQAYLDFQIRRRCNLLLDRGKSHAVTLPPTSQIESDASINA"
     misc_feature    6472..6474
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6478..6480
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6736..6738
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6925..6927
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7319..8575
                     /locus_tag="C8D88_RS38415"
                     /old_locus_tag="C8D88_11558"
     CDS             7319..8575
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006238938.1"
                     /locus_tag="C8D88_RS38415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11558"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_233440145.1"
                     /transl_table=11
                     /translation="MLFRPSAKGYLGWEELSDEGQVAVDETHVGRRVREIRSFRGMSLT
                     ATAQLAGMAPSYLSMIERGLRPVNQRATLEALANALRVSPAELTGKPYAPTDAASEEAH
                     GHIFEVEDAMTAWRIGEVPDAPARPWQQVSAELDLLNLTLRPNADYAAQGALMPSLIRD
                     LLVAASDPKRRTAALVGLIATYKAVAYFAHDLGVAGLPVLAVERMREAAEELDDPVWLS
                     YAAYQRAQLISGTNRSRQYDLAVQTAQVPGARVEVHGLAHLTAALACASRGDADAAQTH
                     LTEATALADRIEPDVSPWMQTNFGRTNVGIWKVSIGLELGAGAKVREIASTVRPGGVSK
                     SRQAQFWIDVGRGLLTERKHRDQGLAALLEAEKLAPQKVRNNVFVRESVAGLLAQARRE
                     AGGRDLRGLAYRVGVAPSG"
     misc_feature    complement(8589..8603)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.3"
                     /tool="antismash"
     gene            8925..9110
                     /locus_tag="C8D88_RS46375"
     CDS             8925..9110
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS46375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_146231814.1"
                     /transl_table=11
                     /translation="MSLPNADPARSPGGSGALESLATDPGWLAARDQLAASIRATSLPT
                     YGGQARLRVAARQEDR"
     gene            9107..9316
                     /locus_tag="C8D88_RS38420"
                     /old_locus_tag="C8D88_11559"
     CDS             9107..9316
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS38420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_11559"
                     /product="hypothetical protein"
                     /protein_id="WP_109640933.1"
                     /transl_table=11
                     /translation="MSGHVWWTSPLDDLTHAIGDSAGPGDGTVDTECGRVLDIVKAGKS
                     PSGSFCDDCLQKVGTKVDDSSRWR"
     gene            9322..9630
                     /locus_tag="C8D88_RS38425"
                     /old_locus_tag="C8D88_11560"
     CDS             9322..9630
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS38425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_11560"
                     /product="hypothetical protein"
                     /protein_id="WP_146231815.1"
                     /transl_table=11
                     /translation="MAAQHAYREGNQWGMTVPELLEDAVAEGRPLHLEWSEDGTTWDWP
                     GNNFDTIEMPVITPEMLAATTPEPMPDADADTDELATATDVLQVDQSWWFTGPAGPR"
     gene            9742..9915
                     /locus_tag="C8D88_RS38430"
                     /old_locus_tag="C8D88_11561"
     CDS             9742..9915
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS38430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_11561"
                     /product="hypothetical protein"
                     /protein_id="WP_211337673.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.1e-06, bitscore:
                     22.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIMIDEPIAADDLFALEHLEFITDVPADAAMNPCTNGTDDGCD
                     PTCASACVTGGV"
     gene            10001..13069
                     /locus_tag="C8D88_RS38435"
                     /old_locus_tag="C8D88_11562"
     CDS             10001..13069
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="C8D88_RS38435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11562"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_109640935.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.6e-184,
                     bitscore: 605.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1e-08,
                     bitscore: 29.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-30, bitscore:
                     100.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRHADHKPLYRHTGVALLRAAATPLSSAPDQWPDLTDIASCRAWL
                     DQMWARDGLAAAVRQASPSLADRIDDIRAGHAMSGKQVRSATVSAVRYVLRSIGRPTPF
                     GLFAGVAPVTLAPVGRVELRAGHRAAARVDAQWLADIITRAEACPQLLERLHVTVNDLA
                     VRRGDRLELPQGTDRARVLCTSAILAAWQAAATPMRFGDLIDNLANDFTTDRLKVRDSI
                     TALLVRPGFLLTSLRAPFTITDPFTHVLTVLHDANAGEVPEIADLLRELDAVHAKLRHH
                     NAPTTSGAEQHEARAALISHMRKLSAAGRTPIAADLLLDNTVELPIKVAQEMAAAASAL
                     LRTTRHPAGDPAWREYQAEFTDRYGVGTLVPLLEVVSPDAGLGYPARFHGSLRSAPAIA
                     LGQRDERLLAMAWQAIANGSHEIVLSHNDVAALIDPDLDERYIPPHVELAARVHCASVD
                     ALNRGEFTLTVAPARSAGTLTSRFTPMATGSGLAEAYRALPAATEGALRAQLSFGPKFV
                     PAENVCRVPAYLDHVIPLGEHRSHDDPATQIPLEDLAVCATRDRLFLVSRSRRRVVEPQ
                     VFHALALDKQPHPLARFLAELPRAFSASWYQFDWGPHVTLPVLPRVRYGRTVLSPAQWR
                     LSTNDLPPEGTGPQGWRELLATWRTRWNCPEVVELRDADRTLRLSLDEPVHATLLHNHL
                     VKHGQAILYEATDVADYGWIDGHAHEIALPLVTTRPTAPVPLRGPLPEVTNQHEQLPGD
                     PSATWLTAKIHTHPERIDGILTTRLPQLLKALPEGTAWWFVRYHSRHETDHLRLRLRPT
                     AEHYAACTIAVGEWAQRVRQAGLITEVRFASYQPEIGRYGHGAALEAAEDVFAADSRLV
                     AAMLRALPAKSVNPTALAVANMVGIVRGLFGTPADAADWLINRTAPAVTIARDILDEAM
                     RISVDQTALRQLPGWMEPVEQAWQARAEALTAYHGYLHSGTDVDINSALESLLHMHHNR
                     VIGINPDHERLCKRLTRHAALAWRAMHQGGDSQ"
     misc_feature    10343..10345
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10469..10717
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_C8D88_RS38435_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.40E-09"
                     /identifier="RREFam001.1"
                     /label="C8D88_RS38435"
                     /locus_tag="C8D88_RS38435"
                     /protein_end="239"
                     /protein_start="156"
                     /score="29.5"
                     /tool="antismash"
                     /translation="VTVNDLAVRRGDRLELPQGTDRARVLCTSAILAAWQAAATPMRFG
                     DLIDNLANDFTTDRLKVRDSITALLVRPGFLLTSLRAP"
     gene            13066..15489
                     /gene="fxlM"
                     /locus_tag="C8D88_RS48880"
                     /old_locus_tag="C8D88_11563"
     CDS             13066..15489
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="C8D88_RS48880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11563"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_233440146.1"
                     /sec_met_domain="LANC_like (E-value: 5.9e-45, bitscore:
                     147.2, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 1.1e-44, bitscore: 146.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTTSPAAPPQHDPTPAWGQSLSYGAAGTALLHVAQARVGLNGW
                     PAARQWVAAMTRSPLAAHPDACLFNGAPAVAFVLRATGNPAYARSLHTLDTHISRLTRH
                     RLDAAHQRIDDGLPARLREFDLINGLTGIGTYLLHAGHDGLLRNVLSYLVRLVCEPITV
                     DGEQLPAWWTCNEPADRPCPQWPGGHANLSIAHGVTGPLALLATAKISGIIVPAHTKAI
                     ENVCAVLDRWQLGTRTTPWWPGTISLHEWHTGTTSQIGPQRPSWCYGTPGVTRAQQLAG
                     VALGDHQRQRAAENALASCITDQQQLDRLDGASLCHGWAGLVQTVRRAADDAGPGSELA
                     TLLPQLHRDFQQHLRDHRPPAGDGLLEGATGVALALYSATEPTFRWDACLLLAAPDRNT
                     EHERNGMTTTETQPEDLRNRMVDHIVENSQAISAEVERVLRTVPRHPFVPDASIEDAYA
                     NRAITIKPGPSGGRPASCISVPTVVAMMLNQLDARPGQRVLEIGAGTGWNAALLAELVG
                     ETGHVSTIDIHSDVTEHAQRALAATGYDRVHIITGDGALGDPENGPFDRIIVTVGPWDL
                     PPAWFDQLAPGGRLVVPLTWRGQTRSVAFVNDNGVLRATDSQLCGFIPMIGDGQNGEQK
                     GEIAEDVLLYWDPDQSVDLDALQGVLDTPASTAWSGTSIVAMESTDLIWPLVTAVEPGT
                     VRFCAGNDAVDAGLAKPAFRYSSVALVEGESLAYMTLKNPEPDAQDKRWELGAIGHGPA
                     GEQLAERLCTVIRAWGEDRAAQPTIAAYRAGTPDDALITGQVIDKQFIRLVVSR"
     gene            15946..17556
                     /locus_tag="C8D88_RS38450"
                     /old_locus_tag="C8D88_11564"
     CDS             15946..17556
                     /EC_number="2.1.1.72"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0009007 - site-specific
                     DNA-methyltransferase (adenine-specific) activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020228555.1"
                     /locus_tag="C8D88_RS38450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11564"
                     /product="type I restriction-modification system subunit M"
                     /protein_id="WP_211337674.1"
                     /transl_table=11
                     /translation="MTTELAWSTTAEDRKKEQERAELHRVIWKIAHDLRGSVDGWDFKA
                     YVLGTLFYRFISENLTAYLNVAERRAGNEDFDYRYLSDADAELGREETVKEKGFFILPQ
                     DLFANVRERASKDENLNETLTRVFTNIEASAIGTASENDIKGLFADLDVNSGKLGPTVA
                     KRNEKLVKLLDAIGSLNFGNGEFNENTIDLFGDAYEYLMQMYASSAGKSGGEYYTPQEV
                     SELLARITVVGKTEVNKVYDPACGSGALLLKFKKVLPDGVRQGYFGQEINLTTYNLCRI
                     NMFLHDIPYEKFDIAHGDTLIDPHHWDDEPFEAIVSNPPYSTRWEGDSNPLLINDERYA
                     PAGVLAPKSKADLAFTMHMLSWLAVNGTAAIVEFPGVLYRGGAEQKIRKYLIDNNYVDT
                     VIQLPPDLFFGVTIATCIIVLKKSKIDDQVLFIDASAEFMRHGNKNKLTVGHQAKILEA
                     FTRREAIDHFAALVDYETIRDNKYNIAVSSYVAAEDTREAVDIKALNTEIARIVARQAE
                     LRTQIDAIVGDLESDDATV"
     gene            17543..18352
                     /locus_tag="C8D88_RS38455"
                     /old_locus_tag="C8D88_11565"
     CDS             17543..18352
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS38455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_11565"
                     /product="hypothetical protein"
                     /protein_id="WP_146231816.1"
                     /transl_table=11
                     /translation="MRLSELLSKAPANEEAQVERFLSARLAWGKHKTIEVGKVAINFKC
                     KTCDDVRTFMSGDKLSCLGVGDRVVSIDACLKCPVCGAAIEAWFLVVSRDELDGPAPTV
                     RLERYVDNRRGMATRVGVGAGDFDDLLERAQLAYEVKLGAGSMVYLRKIFEAITKQVAD
                     IAGIPTTGSNGGRKPFRSLLQEVDEQHHIIPPAFSSDGYKLFSELSEIVHGDSSDEMAL
                     QKYHPCRSLVIGIIQNVASDQEMKQAIDKLGWNIGKLNVPANGVTAS"
     misc_feature    17561..17563
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17858..17860
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18349..19008
                     /locus_tag="C8D88_RS38460"
                     /old_locus_tag="C8D88_11566"
     CDS             18349..19008
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013579.5"
                     /locus_tag="C8D88_RS38460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11566"
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_109640937.1"
                     /transl_table=11
                     /translation="MSEIERLLAEHCPDGIEVKKLGEIGTFIRGRRFTKADMVKEGIPC
                     IHYGEIYTEYGVSARTTVSYVREDLRSQLRYAQPRDVIIAGVGETVEDVGKAVAWIGEG
                     EVAIHDDSFLFRSELNPTYVSYYFQTSTFNVEKEQHVARAKVKRLSSSGLSRVTIPVPP
                     PEVQNEIVRILDSMTELLAELQIELQAELQARTRQYEHYRDQLLTSKRERMSGGRP"
     misc_feature    complement(19238..19252)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.9"
                     /tool="antismash"
     misc_feature    19311..19320
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.35"
                     /tool="antismash"
     gene            19341..19583
                     /locus_tag="C8D88_RS49880"
     CDS             19341..19583
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013579.5"
                     /locus_tag="C8D88_RS49880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="restriction endonuclease subunit S"
                     /protein_id="WP_211337675.1"
                     /transl_table=11
                     /translation="MLEIAPGENSHSNLNARKMKDYTIAVPSPQEQKRIVSILDRLDSL
                     VNKIQSIFLLRLRPAERSMSTTVTSCSRLRSGWRE"
     misc_feature    complement(19362..19377)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.6"
                     /tool="antismash"
     gene            19576..22635
                     /locus_tag="C8D88_RS38470"
                     /old_locus_tag="C8D88_11567"
     CDS             19576..22635
                     /EC_number="3.1.21.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0009035 - type I site-specific
                     deoxyribonuclease activity [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00348.1"
                     /locus_tag="C8D88_RS38470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11567"
                     /product="type I restriction endonuclease subunit R"
                     /protein_id="WP_211337676.1"
                     /transl_table=11
                     /translation="MSKDDGVEAPDSALRYEPIAVSDEATVVATYEPDSGNDQGYQSEA
                     ELEAKFIEMLRQQAYEPLHITSSADLEVNLRRQLELLNSVVFSDDEWKWFFSKKISSKN
                     EGIVEKTARIQEDPIQILARDDGTSKNIKLIDKSNIHANRLQVINQYEAVGEGAGATRK
                     HRYDVTILVNGLPLVHIELKRRGVPLKEAFNQINRYQRESFWADAGLYEYVQLFVISNG
                     THTKYYANTTRARKVAESEGGRRRRKQTSNSFEFTSWWTDAENRRIGDLTAFTRTFFSK
                     HALLNVLTKYCVFDVSRTLLVMRPYQIVAAERILRRMVSSAKATGRKAGGYIWHTTGSG
                     KTLTSFKTAQLASKMEGIDKVLFVVDRKDLDYQTMLEYNRFEKDSVNGSRSTAELKRQL
                     QDHNASIIVTTIQKLSRFIEQNKGHEITKGRVVLIFDECHRSQFGDMGTAVRKAFRRSY
                     LFGFTGTPIFPQNAGGSTKDITEKIFGDRLHSYTIVDAINDGNVLPFRVSYQNTVRAAD
                     DVEDKQVAGIDTEEVLRHPERIRKIVAYVLDHFDTKTMRTKGYSLGEKRVRGFNSMLAT
                     ASIPALKIYYDEFARQQGERAAADPSYQRLKIATIFSYAVNEDEEVGGILDDEAMDADQ
                     LDGSSRDFLERAISDYNAAFGTTYDTSAAKFENYYKDLARRVKDREVDLVIVVNMFLTG
                     FDATTLNTLWVDKNLKSHGLIQAFSRTNRILNSVKAYGNIVCFRNLEKAVDDALVLFGN
                     SEANGVVLLKPYTYYHATYVSLVGQLVEQCPPGTEPRGEAQEKAFVVLFGRILKLRNIL
                     TSFDEFTHDGSLSQRQLQNYTSVYNALWERHRKRNTSEKESILDDVVFEIELIKQVEVN
                     IDYILVLVQRWRDEGQAMTGGEAKMPLRAIEDAIDASPSLRNKKDLIMDFVDSMSVTGE
                     VNDDWRVFVTQRREAELAEIINAERLQPEQTKSFIEAAFRDGAIATHGTAITQFLPPVS
                     RFAKDNNLGAKKERVIAKLTEYFERFSKLS"
     misc_feature    22863..22877
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            23102..23773
                     /locus_tag="C8D88_RS38475"
                     /old_locus_tag="C8D88_11569"
     CDS             23102..23773
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS38475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_11569"
                     /product="hypothetical protein"
                     /protein_id="WP_109640939.1"
                     /transl_table=11
                     /translation="MCSTTLITAAQVTKEFDEVYLPLARKAKNAEHRRWPHELMYQEVD
                     PRVQNMLRIGGADQLAGAVRAKKAMACLLYASSVPLGTAEQHLMRHNLGNEAVGAIRAM
                     ASRTRGLTPAVMRVLAFLHPEIATGDLAERTMVRLELGIPAELVELGMVLGAELTRAQY
                     LSLLQAGITSPDEVEASDATSLANCLTVSEARATQLQALLHERVRQSNESFAPLLPPPT
                     E"
     misc_feature    complement(23107..23121)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            complement(23870..25417)
                     /locus_tag="C8D88_RS38480"
                     /old_locus_tag="C8D88_11570"
     CDS             complement(23870..25417)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015397.5"
                     /locus_tag="C8D88_RS38480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_11570"
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_170155266.1"
                     /transl_table=11
                     /translation="MTRGWNVYGLIRYLMGPGSTEQSAHTDQHVFATWDSRPEVHQPEQ
                     LGTDRFDVGALVAALRAPAALAGVPKRRPREDGWPGTVSRVPKGPVWQCSLRNHPDDPL
                     LTDEQWAEVVADVLHRTGIAEHDDPGGCRWVAIRHAPDHVHIAAVLVRQDTGELVHPHR
                     NYDFRRVKEACNAAEDRYGLTSTGAADRTATPRPTRAENKKASRLHAAGQRRTDVAIRN
                     KLRRQVSSAAAAARSWDEFLEYLALANATVRVRQGHHGRILGYSVTDASDPACRTASGD
                     PLYFAGGKLGPDLTYLKLMIRWKSEETTVPASVQGIVDEVVLPARERMRLRGPLNKTEF
                     GQEALQGIAHATGDMLLALVVVADADRVALLIDAWETYARAGRVPEQILPRRWAAVSRD
                     LRTAANQLIRASVRNPARQRATPCQFIALLIAVGALVAEIAAWHEVHQRHVAARHARAT
                     HGMLVQIAAGQTNHMESSVLASPTAATSKLRRELAKRPPVRALPGHRSAYPKSGRAH"
     misc_feature    complement(24683..24685)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 agcaggcttt actcctaggc tggtcacttc gatcagagcc tcaacgtcgg ggagaggcag
       61 cacacatgac ctacacgccg tccacgcagc acacctccgt accggcaccg cgaggagtgc
      121 cggaccggca catcaacgcg gtgcgccagg cgacggacgt gctgtacgag gtcgtcgagg
      181 agctggacca ggccgccgtg cgcggtcaga gcctgctgcc cggatggacc cgcggacacg
      241 tcctcaccca cctcgcgcgc aacgcggacg cgctggtgaa cctgctcacc tgggcgcgaa
      301 ccggggtcga gcaccaggcc tacacgtcac gcacggaccg cgacgcggac atcgaggagg
      361 gctcgcggcg gctcctgcag ctgatcaagg ccgatctcga ctcagcgtgc ctgcgcttcg
      421 acgccgcgtg ccgcgacatg ccggcgcacg cgtggcgttc cgaggtcatc gcacccagcg
      481 gcaccacgat cgcggcgtcg gtcgtgccgt tgttccggct gcgcgaggtc tggatccacc
      541 tcgtcgacct gaactgcggc gtcgggttcg acgacctgcc cgcggagttc gtggcggagt
      601 tgctcgacga cgccgtgaag cagttcgagg gcagggtcga cccgttcagc atcgaggtcg
      661 acctgccgga gggcggtcag cgcatctgga ccgtcagcgg cccggccagc cgcagctcgg
      721 tcagcgggtc cgccagcgcc gtcctgggct ggctgaccgg caggaccgac ggcaccggcc
      781 tgcgcggtga gctgccggag ctgcccgact ggatctgagt cagcaaccgg tacgcgggcc
      841 gctcgacgaa cttcgtcatc agccagccca gcaccacggc cgaggtgagg aacccggcga
      901 gcagccacca ggaccgcagc ccaacggcgt gcatgcggtc catcaccacg gtgccgatct
      961 gctggtgcac gaggtacacc ccgtacgaga tgccggcgag ccaggtgacg ggcctggcga
     1021 ccggcgcgaa gaacacccag tcggggccgg ccgccgcggc gcacaccagg agtagcagaa
     1081 cagcgaagcc gagcgtcgaa ccgtactcgg tcgtgtgaat cgcctgagcc accaacgtgg
     1141 cggtgaggag cgcgaccagg tgcggggtgc tcatccggtg cttgtgccac agccagatcg
     1201 cgattccggc ggcgaacagc tgcgcccggt gcagcgcgaa accgttgtag atcacgaaga
     1261 gcgtgtgcga gtggtcgagc aacggccgca gcagcagcgg cgtgacgatg agcgcccaca
     1321 ggaagaaccg gagcttcttg ccgcgcatgt gtttcacgag cacggccccg gcgatgaacg
     1381 ccgcgatctg caccggcacg gtccagtacg cgaagtcgac gatgtcgacg tcggggaacc
     1441 actggttgac cagcagcagg ttgtagacga cgtctctgcc gtcgagctgg ctccacccct
     1501 cgggtgcgat ccaccgctgc acggcatatg tcagcagcac ggccgccatg tacgccggca
     1561 gcaggcgcgc gagtcttctc cacaggaact gccccggctt gccgctgtcg agcgaggcgc
     1621 aggcgaagaa ggccgagacg accatcaacg tgctggcgcc catcgacatc gggaagcgga
     1681 acggcagcgg cccgaggtcg gggtggctgc tgacgctggt gagcgtggcg tggtggagca
     1741 gcacacaccc gatggcgacg acccggagga cgtcccagct gaccctgcgg gccgtccggg
     1801 gcttgtgccg ttgcgctgga atcacgagag gcggggacct gtccgtttgg tgctttcgga
     1861 gtaatcggcg ggtcggcggt gatcctttac taccctatga gtgcgacctg tatgcaacct
     1921 gaaggtgtgc gttgcaccgc ttcgagcgac taccgtctgc caccgtggac gtactcgaga
     1981 actacaccgg acacgtcgag ccggacggcc ccgcggcccg ccgcaccctg gacgcgctga
     2041 ccatcacgaa gatctccgtc ggaccgatgg acaacaacgc ctacctgctt gtttgccggt
     2101 ccacgaacga ggcgttgctc atcgacgcgg ccaacgacta cgagcgcctg tccgacctgc
     2161 tcggccacat cccgaaccgc ccccgcctgc gcacgatcgt gacaacccac cagcacgccg
     2221 atcactggca ggcgctgggc gccctggccg gcgcccacgg ttcgaacacc gtcgcccacg
     2281 agctcgacgc ctccgtcctc ccggtcccgc cggacgtcct ggtggaccac ggcgacacca
     2341 tcaacgtggg cgaagtccct ctctcgatca tccacctgcg cggccacacc cccggctcga
     2401 tcgccgtcct ctacgacgac ccggccggcc acccgcacct cttcaccgga gattcactct
     2461 ttccgggtgg tcctgggcgg acaacaagtc cagacaactt cgccagcctg atggccgacc
     2521 tggaagagcg cgtcttcggc aaactgcccg acgacacgtg gttctaccca ggtcacggcg
     2581 acgactcgac cctcggcgtc gagcgtccga agctcgccga atggcgcgcg cgaggctggt
     2641 gagcttggcc gaacggggcc gcctaccgac gacgtaggcg gccccgttcg ctgttccagc
     2701 agcggaacgg ggcctcgatc ggacgtggag gtccgaccgt gcgcacatcg tgccgcatga
     2761 ccctcatcac ggcggtgacg ccgtgagcat cgaagcgatc gcgtgggcgc tgaacagcgc
     2821 cccgatcccg accaatcgca aggactcaag ctcactcgca gtagtcctca tcggcctcgc
     2881 caaccacgct gacccgttcg ggcgaaattc gttcccctcg gtcgcgacgc tgacccgcta
     2941 cacccgtctg tccgagcgaa ccgtgcgcac gacccttgat cgtcttcacg cgttgcgcct
     3001 gatcaagccg tcagacccgg acatcctggc cgcccacatc aagcgcgccg accgccgtcc
     3061 gcagggctgg gacctcgcga tgtgtgacga ggtgcacgtc tcgcacctcg ctgagcagga
     3121 cggggtgcaa tcaacgcgcc acgaggtgca atcaacgacg cgacggggtg caagcactgc
     3181 acccgatcct tcccttaacc gtccgaggaa ccgccccgcg ccgagcgcgc ccggtcggcg
     3241 gtctgcggcg agtgcgacgc tcgtgactcc gatccggtgt cggctcgggt catctggctc
     3301 gacgaggacc gaacccgctc gtcgctgtgc ccgcgctgcc acccagcggt gatgtcgcga
     3361 tgagccgcgt tcacctctcc tactccgagc cggtctcacg gatccaccca cgcggctgga
     3421 cttctccgga gcgctgctac gagtcccgcg ctgcggcgga gaaactgcgc gacgcgacca
     3481 acttcctgtc cggcccggat gcagctcgac gccgcacctg gaacttcacc ccgtgcacct
     3541 gctcagagcc tcggcaggat cagtggctgt cgtgaacgaa ccgacgatct ggatcaagcg
     3601 aacgtgcgtc gtcgccgtcg ctgcagtcgc agcggtggcc gccgtcgtct cgttcgatca
     3661 catgcgggcg ctcgcttcag atgccggtga aggttggaag gcgtggatcc tgccgatctc
     3721 ggtcgacggc atgctcgtct cggcgtcctt ggtgatgctg gcccggaagc gggccggcca
     3781 gccggtcggc gcgctcgctt ggatcggtct catcctcggt ctgctggtgt cgctggctgc
     3841 gaacgtcgca gccgccgaac cgacgctggt cggccgtctc gtggcagcct ggccgcctgt
     3901 ggctctcggc ctgtcctatg aactcttgct gaccttgatt cgcgagacct caaccgttca
     3961 tgaacccgct gaccagcagg ttgtagcagc acagccggtc gttcatgaac acctcgttcc
     4021 cctccctcaa gctcctccca agcgctcgcg gaagttgcta caggactacc tcaacgaggc
     4081 tcgtgaacac ctgggtccgg acgtgaacgt cacccctgca tgggttcgcg aagtcactag
     4141 ctgctcgcgc ggcctctctt cgaagatcgc cgcaagtctc aagacaggga tgcagtgatg
     4201 gcttcgatgc cgctccacga gaggcgggcg ccgaggggtc accatccagc gtccgcagtt
     4261 gcgctgacat aagttcgcgt gatcatggaa tatgcattac ccattcggcg tactgcgact
     4321 acaagtcgta acacatcgcc taatcctttc gatggccatg acacaacgtt agtggagatt
     4381 gatcagcagg cgcagtcgat gtgcgaccat cgtcgctcag gcttgagggg acaccgtgcg
     4441 agacgggatg ctacgtacga ggtggatcat ggttggccta tgcatcgggc tgatcttctc
     4501 gttatacctc gcaactattg acgtcggcac cgtccgtggc tggtggcatc ttattccaag
     4561 cgtgaccgca ataatgcttg cagtagccct tgcctggatc ggctatcagc ctgacctcaa
     4621 gaaaagcgca cttggcaaac cacacccaaa acagcctcgc ctcgaagacg tcgaagctgc
     4681 agcacagtac gttaaggaca agtatggcga tgacgccata cgatacttcc agaacgcctt
     4741 acttgatctg gcgagttacc tagtccgcgt agatcaggaa ctgtcaatcg acggccgaga
     4801 tctctctacc acaacaactc ttacattcag atacgaactg cacgacgatc gacccgaaaa
     4861 tagtcacgac gagaacatct ccgacgaaga cgacagtctc acaaaatccg ttgatgtcac
     4921 gaaaatcaca aagaatgaca gaaagtcgat actagtgccg atcgttacgg caagaaaggg
     4981 ccaccttttt gacaagtttg ccgcacgctc aagcagtggc gctaaggtaa acctgatttc
     5041 ccaatacgag atccgcggcc tcctagcgac cgcgatacag gccctattca cgcagcatct
     5101 aacacaagcc gacggtaacc gcgcaagcct cacaccagat caggaacatg gcctgcgcga
     5161 cgtgatgaac gatgttctca tcaacgccgc atgctttgtc ggcaatacgc cgtcgcgtcc
     5221 agatacctca ttcaagctgg tcgatagccg aagtgaaacc ttagctgata ttgaccacaa
     5281 attatcccag tggccactac tgttcagcaa ggatgtacgg agcaagatta cgagaatttg
     5341 ccgcgtacta acctacaact acctcatagt ggccgaaatg acccagcccg agcagggaaa
     5401 tttcatagtt tcttacgaac acatggtgac gtccgacctc atgcgaacca agcgagaaga
     5461 acttcttcga gccaggtttg gactcgaccc ggtcacaatc gacttgccag tatctcgcgc
     5521 ctttcaagca gacagctttc atttgcagat acaggcacca ccagggcaat atgtatttga
     5581 tcaccactta gaagagcttg gctcgagaaa taagatggaa caggacagct tcgagaacgc
     5641 tcagcctatc cgcccctata tgcgcctcta ccatgaagaa ggccgctcta ttgcccacct
     5701 ctacgtgaga aggcaaggag ctcacccgca cacccaattg tcgacggcca cgagctctcc
     5761 gcacgtcacc gcgccaagct tcaagtccgt aattagattc cgggaaattc cacccggctc
     5821 aatctccgga atcgcactcg tgtcgttaat gaccagcatt ctgatcatgt tcttcacatt
     5881 tgcacgttcg ccgtttaacc ccactggcac attccaagga gcgccagcat tgatccttgc
     5941 tctgcctgcg ttcgtcgccg cagcactcgg acgcggtgtc gacggccgag gccttgcacg
     6001 atcttcgctc actgtatcga tcgcgctagg catcgtggtg ctcaactcgc tactttcagt
     6061 agtgttctac atactcaacg cagtaaacag tctgccagga aacgtaaccg taacactttc
     6121 tttccttcct cagactactc tggtaagcac aaacgggctt tggttgacac tcgggctctg
     6181 gtcaacggcc accacgatat tcatctataa ggagaagagg gcacagacaa actattacct
     6241 caacatgctg acacgatccg cagtcgacaa tgagaaaaag gacattcaaa acgagaggga
     6301 agcaatttaa tgatcttccc catgtctgca gaacagtttc actggctgcc tcgattcaaa
     6361 agacgccacc aagagaacca gcagagggaa gcgacaccac aagcgccgcc tgacccggac
     6421 tggtccgagg ggcgagctgt tttcaggatg cccgagacca ccgatgaaga gttagactta
     6481 atgcgggcca tccactccga agatgagcgc aagatgttta acgtcgcctt gacagaggta
     6541 ctggaagagc tcggcgatcc aggaatgcgc caagaacgac tacagcgggc tcggcagttt
     6601 gaccagaaga acgcccgcag aattcttgcc agggcagcga acgcttatcg cagcaagagg
     6661 ttgactcagc agcagttcaa agacgagtac ttgcggaagt ccatactgtt tgcacccata
     6721 cccgacggta gtcagttacc aatagtcgtg gaaggggagg ccggctatcc gatcgcgcca
     6781 gtcttctcct cactccaagc actgcaagac gaattcggcc cagatcagga gtatatcgag
     6841 ggcatcggcc aggcatacct tgatttccaa atcagaaggc gttgcaatct acttctcgat
     6901 aggggtaagt cacacgccgt gaccttaccg ccgacctctc agatcgaatc tgacgcatcg
     6961 attaacgcat gactaaccga aattccatta ataccctgtc tcttcaaccg gcttaccacc
     7021 agtccgggca caatcaaggg cacgagcgca ctctctatac acacgtgcgg acacctcggt
     7081 cgtgctggac aagctgtccg ataccaacac gtacggcccg cgcgtccgct tctcctgtgt
     7141 gtacagaccc gctcgtggtg ttcgctggcc actccgagtg cgagacgaag gtcactgcct
     7201 agggttgccg cagtccgtga aatcttacga cagcggtctg atgatcacga tggggacgtt
     7261 tagagcaccg accgtggctg atactcggcg gagggcagct agcctgacgt tacgagaggt
     7321 gctgttccgg ccatcggcca aggggtacct cggctgggaa gaactctccg acgaggggca
     7381 ggtggcggtg gacgagacgc acgtcggccg gcgggtccgt gagatccgtt cgttccgggg
     7441 aatgagtctg accgcgacag cgcagctggc gggcatggca ccgagctacc tgagcatgat
     7501 cgagcggggc ctgcggccgg tgaaccaacg ggcgacgctg gaggctctgg ccaacgcact
     7561 gcgcgtgtcg ccggccgagc tgaccggcaa gccctacgcg ccgaccgacg cggcctccga
     7621 agaggcccac ggccacatct tcgaggtcga agacgccatg accgcgtggc ggatcggcga
     7681 ggtgcccgac gcgccggcgc ggccgtggca gcaggtgagc gccgagctgg acctgctcaa
     7741 cctcacgctg cggcccaacg ccgactacgc cgcccagggc gcgttgatgc cttcgctgat
     7801 ccgggacctg ctggtcgccg cgagcgaccc gaagcggcgt acggctgcac tggtgggact
     7861 catcgcgacc tacaaggcgg tggcctactt cgcccacgac ctcggcgtgg ccgggctgcc
     7921 tgtgctggca gtggaacgaa tgcgcgaggc cgcagaagaa ctcgacgatc cggtctggct
     7981 gtcttatgcc gcctaccagc gcgcgcagct gatcagtggc accaaccgat ctcgccagta
     8041 cgacctcgcc gtgcagaccg cgcaggttcc tggtgcacgg gtggaggttc acggcctcgc
     8101 gcacctcacc gcggccctgg cgtgcgcgtc gcggggagac gccgacgccg cccagaccca
     8161 cctgaccgag gccacggcgc tcgcggatcg gatcgagccg gacgtcagcc cgtggatgca
     8221 gaccaacttc ggccgcacca acgtcggcat ctggaaggtc tccatcggcc tggagctcgg
     8281 cgcgggcgcg aaggtccgcg agatcgcctc caccgtgcga ccaggcggtg tgtccaagtc
     8341 gcgtcaggcc cagttctgga tcgacgtcgg ccgcggcctg ctgaccgagc gcaagcaccg
     8401 tgatcaaggc ctcgccgcac ttctggaggc agagaagctg gctccgcaga aggttcgcaa
     8461 caacgtcttc gtccgcgaat cggtggcagg cttgctcgct caagcccggc gcgaggccgg
     8521 cggccgcgac cttcgcggcc tggcatacag ggtcggcgta gccccatccg ggtgatccac
     8581 gccgcccatt cacaagttgt gaaatagcga tctagggtcc cacctagcgt cactttccag
     8641 atacgggagg tgacgccagg tgggactttt gctgttgacg aggttgcggc atcaggtcgc
     8701 gccagtcctc gccttccgtt cgcacgctgc ggtgtcacgg ccggttgctc cccgacgctc
     8761 cggccgtgac accgcgccca ccgcatcctg cgcccttctc gacgccgaca ccgtgctgat
     8821 ctggtcggcc cttccagcgc agagtcatac gagcagcgag ccacattctc cttcctcggg
     8881 aatgcgggtc gctgtcgcgc cgtacgtgaa cggagacgcc gaccatgtcc ttgcccaacg
     8941 ccgatcccgc tcgatcgcct ggtggcagtg gggcactcga atcgctcgcc accgatccgg
     9001 gctggctggc cgcccgtgac cagcttgctg cgtcgatccg cgcaaccagc ctgccgacct
     9061 acggcgggca ggctcgcctt cgcgttgctg cgcgccagga ggaccggtga gcggccacgt
     9121 ctggtggacc tcgccgctgg acgacctgac ccacgcgatc ggggacagcg ccggccctgg
     9181 cgacggcacg gtagacaccg agtgcggccg ggtgctcgac atcgtgaagg cgggcaagtc
     9241 cccgagcggc agcttctgcg acgactgcct gcagaaggtc gggacgaagg tagacgacag
     9301 cagccgctgg cggtgagcgc cgtggcagct cagcacgcct accgcgaggg caaccaatgg
     9361 ggcatgacgg ttcccgaact gctggaggac gccgtcgccg aaggacgacc cctgcacctg
     9421 gagtggagcg aggacggcac cacgtgggat tggcccggca acaacttcga caccatcgag
     9481 atgcccgtca tcacccccga aatgctcgcg gccacaacgc cagagccgat gcccgacgcg
     9541 gacgccgata cagatgaact ggccaccgcg accgacgtcc tgcaggtcga ccagagctgg
     9601 tggttcaccg gcccagcggg gccgcgatga cttccgggag ctcacccatg agtccacccg
     9661 gcaagccctg gctgaatgcc attgtcccac aacgctttcc agccaggttg atgttgaacc
     9721 accgaacaaa caggggatga catgtcattg atcatgatcg acgagcccat cgccgcagac
     9781 gatctgttcg cgttggagca cttggagttc atcaccgatg tcccggctga cgccgcgatg
     9841 aacccgtgca ccaacggaac cgacgacggc tgcgacccga cctgcgcatc agcgtgcgta
     9901 accggaggcg tgtgacacca gcagttcccg atgcgcctcg ggggctaggc ggttctggtc
     9961 cccgaggcac tcattctcgt tgtcacatct ggaggaacgg atgcgtcacg ctgaccacaa
    10021 gccgctgtat cggcacactg gagtcgcgct gctgcgagcc gcggctacgc cgctgagcag
    10081 cgctcccgac cagtggcccg acctgaccga catcgcttcc tgccgggcat ggcttgacca
    10141 gatgtgggca cgcgacggtt tggccgcggc tgtgcggcag gccagcccgt cgctggccga
    10201 ccgcatcgac gacatccgcg ccgggcacgc catgtccggc aaacaggttc gcagcgccac
    10261 cgtgtccgcc gtgcgctacg tgctgcgcag catcggacgg cccacgccct tcgggctgtt
    10321 cgccggcgtt gctcccgtga cgttagcccc ggtcgggcgt gtcgagctac gagcggggca
    10381 ccgggccgcg gcacgggtcg acgcgcagtg gctggccgac atcatcacgc gagccgaagc
    10441 ctgcccacag ctgctggaac gactgcacgt cacggtcaac gacctcgcgg tgcgccgagg
    10501 tgaccggctg gagctcccgc agggaacgga ccgggcgagg gtgctgtgca cctccgcgat
    10561 cctcgccgcg tggcaggccg ccgcgactcc gatgcggttc ggcgacctca tcgacaatct
    10621 ggccaacgac ttcaccaccg accgcctcaa ggtccgcgac agcatcaccg ctctactcgt
    10681 gcgtccggga ttcctgctga caagcctccg cgcgccgttc accatcaccg acccgttcac
    10741 ccatgtgctg accgtcttgc acgacgcaaa cgccggcgaa gtgcccgaga tcgcagacct
    10801 gctgcgcgag cttgacgcgg tgcacgccaa gctgcggcac cacaacgccc ccacgacctc
    10861 gggtgccgag cagcacgagg cccgcgcagc attgatcagc catatgcgca agctatccgc
    10921 ggcaggacga acgcccatcg ccgcagatct gttgctggat aacacagtcg agctgccgat
    10981 caaggtcgcg caggagatgg cagcagccgc gagtgcacta ctgcgcacca cccgccaccc
    11041 cgccggtgac ccggcctggc gcgagtatca ggccgagttc actgaccgtt acggcgttgg
    11101 cacacttgtg ccgctactcg aggtcgtgtc gcccgatgcc ggcctcgggt atccggcacg
    11161 cttccacggc agcctgcgct ccgctcccgc cattgcgctc gggcaacgcg atgaacggct
    11221 gctggcaatg gcgtggcagg caatagccaa cggcagccac gaaattgtct tgtcccacaa
    11281 cgacgtcgct gcgctcatcg acccggacct cgacgagcgt tacattccgc cgcacgtcga
    11341 gctggccgcg cgcgtgcact gcgccagcgt ggacgcgctg aaccggggcg aattcacgct
    11401 caccgtcgca cccgcccgct cagcaggaac actcaccagc cggttcaccc cgatggccac
    11461 tgggtccggt ctcgctgagg cctaccgggc gcttcccgct gcgactgagg gtgcgctgcg
    11521 cgcgcagttg agcttcggcc cgaagttcgt gcccgccgag aacgtctgcc gggtgcccgc
    11581 ctacctcgat cacgtgatcc cgcttggcga gcaccgcagc cacgacgacc ccgcgaccca
    11641 gatcccgctg gaggacctgg ccgtctgtgc aacccgtgac cggctcttcc tggtcagccg
    11701 ctcacggcgt cgggtggtcg agccgcaggt gttccacgcc ctcgccctgg acaagcagcc
    11761 gcatccgctg gcgcggttcc tggccgagct gccgcgcgca ttcagcgcct cctggtacca
    11821 gttcgactgg ggtccgcatg tgaccctgcc ggtgttgcct cgggtgcgct acggccgcac
    11881 agtgctgtcc ccagcgcagt ggcgtctgtc caccaacgac ctgccgccag agggcactgg
    11941 cccgcagggc tggcgcgagc tgctcgccac ctggcggacg cgctggaact gtccggaggt
    12001 ggtggaactg cgcgatgccg accgcacact gcggctgagt ctcgacgagc ccgtccatgc
    12061 cacgctcctg cataaccacc tcgtcaagca cggccaggcc atcctctacg aagccaccga
    12121 cgtggccgac tacggctgga tcgacggcca tgcacacgag atcgcgctgc cgctggtcac
    12181 cacccgtcca accgcccctg tcccgttgcg cggtccgcta cccgaggtaa ccaaccagca
    12241 cgaacaactc cccggcgatc ccagcgccac ctggctcacc gcgaagatcc acacccaccc
    12301 ggagcgtatc gacggcatcc tcacgacgcg cctgccgcag ctgctcaagg cccttcccga
    12361 gggcaccgcc tggtggttcg tgcgatacca cagccgacac gaaaccgatc acctgcggct
    12421 acgtctgcga cccacagccg agcactacgc tgcgtgcacg atcgcggtag gggaatgggc
    12481 gcagagggtg cggcaggcag gtttgatcac ggaggttcgg ttcgcctctt accagcctga
    12541 gatcggccgc tacgggcacg gcgcggcgtt ggaagcggcc gaggacgtct tcgccgccga
    12601 ctcgcggttg gtcgccgcca tgctccgtgc cctgcccgcc aagtcggtca accccaccgc
    12661 gctggccgtg gcgaacatgg tcggcatcgt ccgcggactt ttcggcacac ccgccgacgc
    12721 ggccgactgg ttgatcaacc gcacagcgcc cgccgtcacc atcgcacgag acatcctcga
    12781 cgaggcaatg cggatctcgg ttgaccagac cgcgctacgg cagctgcctg gctggatgga
    12841 accggtcgag caggcctggc aggcccgcgc cgaggcgttg actgcctacc acgggtatct
    12901 gcactccggc accgacgtcg acatcaactc cgcactggag tcgctgctgc acatgcacca
    12961 caaccgggtc atcggcatca atcccgacca cgagcgcctc tgcaagcgcc tcaccaggca
    13021 tgccgcgttg gcctggcggg caatgcacca aggtggcgat tctcaatgac gtcaacaacc
    13081 tcacccgccg cgccgccgca gcacgatccc actcccgcat ggggacagtc gctgtcctac
    13141 ggcgcggccg ggaccgcgct gctgcacgtc gcccaggctc gcgtcggcct caacggctgg
    13201 ccagccgcac gccagtgggt cgcggcaatg actcgcagcc cactcgccgc ccaccccgac
    13261 gcgtgtctat tcaacggcgc gcccgccgtc gcgttcgtgc tgcgcgccac gggaaatcct
    13321 gcctatgctc gctcgctgca cacactcgac acgcacatct cacgcctgac gcggcatcgc
    13381 ctcgacgcgg cgcaccagcg catcgacgac ggcctccctg cacgtctgcg cgagttcgat
    13441 ctgatcaacg gactgaccgg gatcgggacc tacctactgc acgccggcca cgacgggctt
    13501 ctgcgcaacg tgctctccta cctcgtgcgg ctggtgtgcg agccgatcac ggtcgacggc
    13561 gagcagctgc ccgcttggtg gacctgcaac gaacccgccg atcgtccctg cccgcagtgg
    13621 cctggcggac atgccaacct gtcaatcgct catggcgtca ccggaccgct ggccttgctg
    13681 gcgaccgcca agatcagcgg gatcatagtg cccgcgcaca ccaaggcaat cgagaacgtc
    13741 tgcgcggtgc tcgaccgctg gcagctcggc acccgcacca caccgtggtg gccgggcacc
    13801 atcagcctgc acgagtggca cacgggcacc accagccaga ttggtccgca gaggccgtcg
    13861 tggtgctacg gcacacccgg cgtcacccgc gcacagcagc tcgcgggtgt cgccctcggc
    13921 gaccaccagc ggcagcgcgc cgccgagaac gcgctcgcct cgtgcataac cgaccagcag
    13981 cagctcgatc ggctcgacgg cgcgtcgctg tgtcacggct gggccggact ggtccagact
    14041 gtccgccgcg ccgcggacga cgctgggccc ggcagcgaac tcgccacgct cctgccgcag
    14101 ctgcacagag acttccaaca gcacctgcgc gatcaccggc caccggccgg ggacggcctg
    14161 ctggagggcg cgaccggagt cgcgctggcc ctgtactcgg cgaccgagcc cacgttccgc
    14221 tgggacgcat gcctgctcct cgccgcacct gaccggaata ctgaacacga gaggaacggg
    14281 atgactacca cggaaaccca gcccgaagac ctgcgcaacc ggatggtcga ccacatcgtg
    14341 gagaacagcc aagcgatatc ggccgaggtc gagcgggtcc tgcgcacggt tccccgccac
    14401 ccgttcgtgc cggacgcaag catcgaggat gcctacgcta accgggccat caccatcaag
    14461 cctggccctt ctggaggcag gcccgccagc tgtatctccg tgcccacagt cgtcgcaatg
    14521 atgctcaacc agctcgatgc ccgtcctggc cagcgcgtcc tggagatcgg cgccggcacc
    14581 ggctggaacg ccgccctgct cgccgaactc gtcggcgaga ccggccacgt cagcacgatc
    14641 gacatccatt cagacgtcac cgagcacgcc caacgagcac tcgccgcgac cggttacgac
    14701 cgcgtgcaca tcatcaccgg agacggtgcg ctcggcgacc ccgagaacgg cccgttcgac
    14761 cgcatcatcg tcaccgtcgg tccctgggac ctgcccccgg cctggttcga ccagctcgcc
    14821 cccggcggcc ggctcgtcgt cccgctgacc tggcgtggtc agacccgcag cgtcgcgttc
    14881 gtcaacgaca acggcgtgct gcgcgccacc gacagccagc tgtgcggctt catcccgatg
    14941 atcggcgacg gccagaacgg cgagcagaaa ggcgagatcg ccgaggacgt cctgttgtac
    15001 tgggaccctg accagtccgt ggatctcgat gccctgcaag gggttctgga cacccctgcg
    15061 agcaccgcgt ggtccggcac gtcgatcgtg gccatggagt ccaccgacct catctggcca
    15121 ctggtcaccg cagttgagcc ggggacggtg cgcttctgtg ccggaaacga cgccgtcgac
    15181 gctggactgg ccaagcccgc cttccgctac agcagcgtcg ccctcgtcga gggcgaatcg
    15241 ttggcgtaca tgacgttgaa gaaccccgaa cccgacgcgc aggacaagcg ctgggaactc
    15301 ggagcgatcg gccacggccc tgctggagag cagctcgccg aacggctgtg caccgtgatc
    15361 cgtgcctggg gcgaggatcg cgccgctcag cccaccatcg ccgcctaccg cgcgggaaca
    15421 ccggacgacg cgctcatcac tggtcaagtg atcgacaagc agttcatccg gctggtcgtc
    15481 tcacgctgat cgcccatcgg tcccatccgt accgatattg gccccgtctc ctgccggaca
    15541 ccgtcggcag gagatgggcg ctccaggccg taaaacgcag cgaagaactc ggcgcgggtt
    15601 cgaagcgcca gggtcggtgc tgtactcctg cggctcgtat cgcgtgcgat ccgtcaacct
    15661 agggtgggtc gaagatagct acgatgccga cgatcggccg cacgacgacc tcgccgtcga
    15721 ccacgacgct tagacttgtc gatgacagca acttgcatcc ctgagttgcg tctgccttcg
    15781 tcgcgagagg ggcactgacc tgctaaggaa cctcgaactc gggatcgtca tgtgtcggcg
    15841 gccacgggct gagttgtggc gacctagcgc cacgttggca cgtttcaagc acgctctgcc
    15901 cgaggtaaca cgagatgctg ttgggctctg gtaagacttc accctgtgac gacagagctg
    15961 gcctggagca ccactgctga ggaccgcaag aaggagcagg agcgcgccga actccatcga
    16021 gtgatctgga agatcgctca cgacctgcgc ggaagcgtgg acggctggga cttcaaggcc
    16081 tacgtgctag gcacgctgtt ctaccgattc atctcggaga acctgacggc ttaccttaac
    16141 gtggccgagc gccgagcagg caacgaggac ttcgattacc gctacctgtc cgatgccgac
    16201 gccgagctcg gacgcgaaga gacggttaag gagaagggct tcttcatcct gccccaggac
    16261 ctcttcgcga acgtgcggga gcgggccagc aaggacgaga acctcaacga gactctgacg
    16321 cgggttttca ccaacatcga agccagcgcg atcggcaccg cttccgagaa cgacatcaag
    16381 ggccttttcg ccgacctcga cgtgaacagc ggaaagctcg gccccaccgt cgcgaagcgc
    16441 aacgaaaagc tggttaagct tctcgacgca atcgggtcgc tgaacttcgg caacggcgag
    16501 ttcaacgaga acaccattga cctgttcggc gacgcgtatg agtacctgat gcagatgtac
    16561 gcgtcctcag ccggcaagtc tggcggggag tactacacac cgcaggaggt ctccgagctg
    16621 ctcgctagga ttacggtggt cggcaagacc gaggtaaaca aggtatacga ccccgcctgc
    16681 ggctcgggtg cgctgttgtt gaagttcaaa aaggtgctgc ccgatggagt ccggcagggc
    16741 tacttcggtc aggagatcaa cctgaccacg tacaacctgt gccggattaa catgtttctg
    16801 cacgacattc cgtatgagaa gttcgacatc gcccacggtg acacgctgat cgacccgcac
    16861 cattgggatg acgagccgtt cgaggcaatc gtctccaacc cgccttactc cacgcgctgg
    16921 gaaggtgact cgaacccgct gctgatcaac gacgagcggt acgcacctgc cggtgtgctg
    16981 gcaccgaaat cgaaggctga ccttgcgttc acgatgcaca tgctgtcgtg gctggcggtc
    17041 aatggaacgg ccgcgatcgt cgagttcccc ggtgtgctct accgcggcgg tgcggagcag
    17101 aagatccgta agtacctcat cgacaacaac tacgtcgaca ccgtcatcca gctcccaccg
    17161 gacctcttct tcggagtcac gatcgcgacc tgcatcatcg tattgaagaa gtcgaagatc
    17221 gatgatcaag tgctctttat cgacgcctcg gccgagttca tgcgtcacgg caataaaaac
    17281 aagctcaccg tcggccacca agcgaagatt ctggaggcgt tcacgcgccg ggaggccatc
    17341 gaccacttcg cggctctggt cgactacgag accatccgcg acaacaagta caacatcgcg
    17401 gtcagttcgt acgtcgcggc cgaggacacc cgcgaagcgg tcgatatcaa ggcgttgaac
    17461 accgaaattg ctcggatagt cgcccgtcaa gccgagctgc gcacccaaat cgacgctatt
    17521 gtcggcgacc tggaatccga cgatgcgact gtctgaattg ttatccaaag cccctgccaa
    17581 cgaggaagcg caggtcgagc gcttccttag cgcccgcctg gcctggggca agcataagac
    17641 gatcgaggtc ggcaaggtcg caatcaactt caagtgcaaa acctgcgacg acgttcgaac
    17701 gttcatgtcg ggcgacaagc tgtcctgcct cggcgttggt gatcgcgtag tgagcatcga
    17761 cgcgtgtctc aaatgcccag tctgcggagc tgccatagaa gcctggtttc tcgtagtttc
    17821 cagggatgaa ctggacggac cggcaccgac cgttcggtta gagcgctatg tagacaaccg
    17881 gcgcggcatg gcgactcggg ttggagtcgg cgccggtgat ttcgatgacc tgctggagcg
    17941 tgcgcaactc gcttacgagg taaagctcgg tgcggggtcc atggtttacc ttcggaagat
    18001 ctttgaagcg atcaccaagc aggtcgccga tattgcaggc ataccaacta caggaagcaa
    18061 cggtggtcgc aagccgttcc gaagcctcct tcaagaggtc gatgagcagc atcacatcat
    18121 tcccccggcg ttctccagtg atggatataa gttgttcagc gagctgagtg agatcgtcca
    18181 cggagattca agtgacgaaa tggccctgca gaagtaccat ccatgccgaa gcttggtcat
    18241 tggaatcatc cagaatgtcg ccagtgatca ggagatgaag caggcaatcg ataaactcgg
    18301 atggaatatt ggcaagctga atgttcccgc gaatggtgtg acggcgtcat gagtgagatc
    18361 gaaaggctgc ttgccgagca ttgcccggat ggcattgagg tcaaaaagct cggcgagatc
    18421 ggtaccttta tccgtggacg gcgcttcacc aaggccgaca tggtcaagga aggaatcccc
    18481 tgtatccact acggggagat ttacacagaa tacggtgtgt ctgcgcgcac taccgtttcg
    18541 tatgtgaggg aggacctgcg tagtcagttg cgctacgccc agccgcggga cgtgattatt
    18601 gccggcgtcg gagagacggt tgaggatgtg ggtaaggccg tggcatggat cggcgaaggg
    18661 gaagtcgcga tccacgatga ctcgtttctt ttccggagcg agctcaaccc gacctacgtc
    18721 tcctactact tccagaccag cacctttaat gttgagaaag agcagcatgt cgcccgcgca
    18781 aaggtgaaga ggctctccag tagcgggctg agcagagtta ccatcccggt tcctccgcct
    18841 gaggttcaga acgaaatcgt acggatcctt gattcgatga ccgagctgct agccgagctg
    18901 caaatcgagc tgcaagccga gctgcaagcg cgaacccgcc agtacgagca ctaccgcgac
    18961 caactcctca cgtcgaagag ggagagaatg tcaggtggac gaccttgatt gaaatctctc
    19021 tgaaggtcac ttctgccggc acaccgctca ccagccatcc cgagtactac ggcgccgata
    19081 tcccgtggtc gcacgcagga cgtcgactac aaggtggtcg agtggatcgg cgtgaccatc
    19141 gctgaggcgg ggccaaagaa ttcttcgaca aagtggattc ccgcaaactg tgtgatcgtg
    19201 gctatgtacg gcgcaactgc agcgaaggtt gcgatcaatg ggatcgctct gactaccaat
    19261 caggcttgct acaacctgga gattgactcg acccaggcga gcgcgcctca tgttttttgc
    19321 tggttgcgta acgaattcct gtgcttgaaa tcgccccggg ggagaacagt cattccaatc
    19381 tgaatgcacg aaagatgaag gattacacga tcgcggtccc gtcaccgcaa gagcagaagc
    19441 ggattgtgtc gatcctggac aggcttgatt cactcgtgaa taaaattcaa tcgatctttc
    19501 tattgagatt gaggcccgcc gaaagaagca tgagcactac cgtgacaagt tgttcacgtt
    19561 tgaggagtgg gtggcgtgag taaggatgac ggtgtggagg caccggactc ggcgttgcgg
    19621 tacgagccga tcgcggtgag cgacgaggct acggtagtcg cgacatacga accggacagc
    19681 ggcaacgatc agggttacca gtccgaggcg gagcttgagg ccaagttcat cgagatgctg
    19741 cggcagcagg cctacgagcc tcttcacatc acatcgtcgg ctgacctgga agttaatctt
    19801 cgtcgccagt tggaactgtt gaacagcgtg gtcttcagtg acgacgagtg gaaatggttc
    19861 ttttccaaaa agatttcctc gaagaatgaa ggcatcgttg agaagacagc gcgcatccag
    19921 gaggatccga tccagatcct cgcgcgtgac gacgggacga gcaagaacat caagctgatc
    19981 gacaagtcga acatccatgc caaccgactg caggtgatca accagtacga ggcggttggt
    20041 gagggtgccg gggcaactcg caagcaccgc tatgacgtga cgatcctggt aaacgggctg
    20101 ccactggtgc atatagagct gaagcggcgc ggcgtgccct tgaaggaggc attcaaccag
    20161 atcaaccgct accagcggga gtcgttctgg gccgatgccg gactgtacga gtacgtccag
    20221 ctattcgtga tctccaacgg cacgcacact aagtactacg ccaacacgac tcgtgcccgg
    20281 aaggttgctg agtctgaggg cggcaggcgt aggcggaagc agacatcgaa ctcgttcgag
    20341 ttcacctcgt ggtggaccga tgcggagaat cgacgcatcg gcgacctcac cgcgttcacg
    20401 cggacgttct tctccaagca cgcgctgcta aacgtgttga cgaagtactg cgtcttcgac
    20461 gtctcccgca cgctgctggt gatgcggcct taccagatcg tggcagctga gcgcatcctg
    20521 cggcgaatgg tgtcctcggc gaaggcgacc ggacggaagg ccggcggcta catctggcac
    20581 accaccgggt ccgggaagac actgacatcg ttcaagactg cgcagctcgc gtcgaagatg
    20641 gagggtattg acaaggttct cttcgtagtg gaccgcaagg acctcgacta ccagacgatg
    20701 ctggagtaca accgcttcga aaaggactcg gtaaacgggt cgcgctcgac tgccgagctc
    20761 aagcggcaac tccaggacca caacgcctcg atcatcgtca ccacgatcca gaagctgtcg
    20821 cggttcattg agcagaacaa aggccacgag atcaccaagg gtcgcgtggt gttgatcttc
    20881 gacgagtgcc accggagcca gttcggggac atggggaccg cggtccgcaa ggcgttccgc
    20941 cgctcctacc tcttcgggtt caccggcacc ccgatcttcc cgcagaacgc cggtgggtca
    21001 acaaaggaca ttaccgagaa gattttcggc gaccgactgc acagctacac gatcgtggat
    21061 gctatcaacg acggaaacgt gctgcccttc cgcgtttcct accaaaacac cgtgcgggca
    21121 gcggacgatg tcgaagataa gcaggtcgcc gggatcgaca ccgaagaagt gctgcgccat
    21181 cccgagcgaa tccggaagat cgtggcgtat gtcctcgacc acttcgatac caagaccatg
    21241 cgcacaaagg ggtacagcct gggtgagaag cgggtccgcg gcttcaactc gatgttggcg
    21301 accgcgtcga tccctgcgtt gaaaatctat tatgacgagt tcgctcggca gcagggcgag
    21361 cgtgcggcag ccgacccgtc gtaccagcgg ctgaagatcg ccacgatctt cagctacgcg
    21421 gtcaacgagg acgaggaggt tggcggcatt ctcgatgacg aggcgatgga cgcggatcag
    21481 ctcgatggct cctcccgcga cttcctcgaa cgcgcgatca gcgactacaa cgccgccttc
    21541 ggcacgacgt acgacacctc ggcggcgaag ttcgagaatt actacaagga cctcgcgcgt
    21601 cgagtgaagg atcgtgaggt cgacctggtc atcgtggtca atatgttcct gactgggttc
    21661 gacgcaacaa cactgaacac gctgtgggtg gacaagaacc tgaagtccca cggactgatc
    21721 caagcgttct cccgcaccaa ccggatcctc aactcggtca aggcctatgg caacatcgtc
    21781 tgcttccgca atctggagaa ggccgtcgac gatgccctgg tgcttttcgg caactccgag
    21841 gccaacggag tggtgctgct caagccgtac acctactacc acgccacgta cgtcagtctg
    21901 gttgggcaac tcgtggagca gtgcccgccc ggaaccgagc cacgtgggga ggctcaggag
    21961 aaggcgttcg tcgtgctgtt cggtcggatc ctcaaactgc gcaacatcct gacctccttc
    22021 gacgagttca ctcacgacgg gtcgctgtcg caaaggcaac tgcagaacta cacgagcgtc
    22081 tacaacgcac tgtgggagcg gcatcgcaag cggaacacca gcgagaagga gtcgatcctc
    22141 gacgacgtcg tcttcgagat cgagctcatc aaacaggttg aggtcaacat cgactacatc
    22201 ctggtgctag tgcagaggtg gcgtgatgag ggccaggcca tgactggcgg agaagccaag
    22261 atgccgctgc gcgccatcga ggatgccatc gatgccagcc catcgctgcg gaacaaaaag
    22321 gacctgatca tggacttcgt cgactccatg tcagtcaccg gcgaggtcaa cgacgactgg
    22381 cgcgtcttcg tcacccagcg acgagaagct gaactcgctg agatcatcaa cgccgagcgc
    22441 cttcagcccg agcagacgaa gtcgttcatt gaagcggcct tccgcgacgg cgcgatcgca
    22501 acccacggaa cggcgatcac ccagttcctg ccaccggttt cgcgctttgc aaaggacaac
    22561 aacctcggcg ccaagaaaga gcgcgtcatc gcgaagctga ccgagtactt cgagcgcttc
    22621 tccaagttga gctgagaggc accgccatct cgggtcacca ggcctttcct gtccgaccgc
    22681 ttccatccgg ccgcagccgg gtcacccaca ggccgcttgc tgttctgctc gacctgcgcc
    22741 cagcccgctg cccagacggg tggcgcgacg agacgatcgc gccatgtgaa gtctgtgtcg
    22801 cccgtgatcg acagctgggc tcgcgccgga gcaggcgcca tggctgtcgg ccgccagaag
    22861 tgatcaacat cgtcggtggc acaagccggg taagcgatgt gggccttacc gtcgtgcgcg
    22921 cgactgcacg gagcttggca tgactgtgag tgtgccgacg aagcctgcac cgggcgcctt
    22981 gaggaggtcg tcacgctggc ttccgagcag gtgaagatcc ggctggccgg acctgctcgc
    23041 cagattggat gatcactagc cggaatgtcg tcgacggcga cccgcggccg catgttgcgg
    23101 catgtgctcg acgacgctga tcaccgccgc tcaggtgacc aaggagtttg acgaggtcta
    23161 cctcccgttg gccagaaagg ccaagaacgc agaacatcga cgatggccgc acgagttgat
    23221 gtaccaggaa gtcgatccgc gcgtgcagaa catgctgcgc atcggcggcg ccgatcagct
    23281 cgctggtgca gttcgggcga agaaggccat ggcgtgcctg ctgtacgcga gcagtgtgcc
    23341 cctcggcacg gcggaacaac acctcatgcg acacaacctc ggcaacgaag ccgtcggcgc
    23401 gatccgtgcc atggccagcc gcacgcgcgg cctgacaccg gccgtcatgc gggtgctcgc
    23461 gttcctgcac ccggagatcg caacgggcga cttggctgag cggaccatgg tgcgtctcga
    23521 actcggcata ccggctgagc tcgttgagct cggcatggtt ctcggcgccg agctgacacg
    23581 ggcgcagtac ctctcactgc tgcaggctgg cataacgagc cccgatgagg tcgaggccag
    23641 cgacgcaacg agcctggcga actgcctcac cgtctccgaa gccagggcca cccaactcca
    23701 ggccctcctg cacgaacgtg tgcggcaaag caacgagtcg ttcgcgccct tgctaccacc
    23761 gcccactgag taacacgagc atcggcgtcc agtgtggcaa ccggcggaat tcgtccagcc
    23821 acattcggct ccagcccgga gttctgggag acggtggtgg acgagcccgt cagtgcgcgc
    23881 gaccgctctt cggataggcc gatcgatggc ccgggagcgc tcgtaccggc ggccgcttgg
    23941 ccagttctcg acgcagtttt gacgtcgcgg cggttggcga cgccagaact gatgattcca
    24001 tgtggttcgt ttgccctgcc gcaatttgaa ccagcatgcc gtgggttgcc cgagcatgtc
    24061 gggctgccac atggcgctga tgcacctcgt gccacgccgc aatctcggcg acgagcgctc
    24121 ccaccgctat caagagcgcg atgaactggc agggcgtggc ccgttggcgt gctggattac
    24181 gcacactcgc tctgatcagt tggttggcag ctgtacgcag atcgcgcgac accgctgccc
    24241 accgccgcgg caggatctgc tcgggtacgc ggccggcacg cgcgtatgtc tcccatgcgt
    24301 cgatcagcag tgccactcga tccgcatccg cgacaacgac gagagccaac aacatgtcgc
    24361 ctgtcgcgtg agcgatgccc tgcagagctt cctgtccgaa ctcggtcttg ttcaatggtc
    24421 cgcggagccg catccgctca cgtgcaggca gcaccacctc atcgacgatc ccctgcaccg
    24481 aagcgggcac ggtcgtctcc tccgatttcc acctgatcat gagcttcaag taggtgagat
    24541 ccggaccgag ctttcctccg gcgaagtaca gcggatcacc cgacgcggtc cggcacgccg
    24601 ggtcggaggc gtccgtgacc gagtagccga ggatccggcc gtggtgacct tggcggacgc
    24661 gtacggtcgc attggccaac gctaagtact ccaggaactc gtcccagctc cgcgcggcgg
    24721 cagcagcact ggagacctgg cgacgcagct tgttgcgaat cgcgacgtcc gtccgcctct
    24781 ggccagcggc atggagtctg gacgccttct tgttctcagc gcgagtagga cgaggtgtcg
    24841 ccgtccggtc ggcggcaccg gtgcttgtga ggccataccg gtcctcggcc gcgttgcacg
    24901 cctccttcac tcgccggaag tcgtagttgc ggtgtgggtg cacaagttcg ccggtgtctt
    24961 gtcgaaccag cactgcggcg atgtgcacgt ggtcaggcgc atgacggatc gcaacccatc
    25021 ggcagccgcc tggatcatcg tgctcagcga tcccggtgcg gtgcagcacg tccgccacaa
    25081 cctctgccca ctgctcgtcc gtcagcagag gatcgtcagg atggttacgc aacgagcact
    25141 gccagacagg acctttcgga actcggctga cagtgcctgg ccagccgtcc tcacgcggac
    25201 gccgtttcgg caccccggcg agcgccgcag gtgcccgaag agctgcgacc aaggcaccga
    25261 cgtcgaaccg gtcggttccg agttgctcgg gctggtgcac ctcgggacga ctgtcccacg
    25321 tcgcgaagac gtgctgatcc gtgtgcgctg actgctcggt gcttcctggt cccatcaggt
    25381 agcggataag gccgtagacg ttccagccgc gcgtcacctt tccaatcatg tcgactcgaa
    25441 gcgatcgacg atgcgtgcca ggagtgcatc gacagcggac aagcgctca
//
