LOCUS       NZ_QGHB01000007        22595 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Lentzea atacamensis strain DSM 45480 Ga0215650_107, whole genome
            shotgun sequence.
ACCESSION   NZ_QGHB01000007
VERSION     NZ_QGHB01000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Lentzea atacamensis
  ORGANISM  Lentzea atacamensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Lentzea.
REFERENCE   1  (bases 1 to 442485)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 442485)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2018) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.10.1
            Expected Final Version            :: No
            Genome Coverage                   :: 90.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003148865.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 16:35:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,333
            CDSs (total)                      :: 9,254
            Genes (coding)                    :: 9,110
            CDSs (with protein)               :: 9,110
            Genes (RNA)                       :: 79
            rRNAs                             :: 6, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (16S, 23S)
            partial rRNAs                     :: 6 (5S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 32 of 144
            Pseudo Genes (incomplete)         :: 121 of 144
            Pseudo Genes (internal stop)      :: 2 of 144
            Pseudo Genes (multiple problems)  :: 11 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:50:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 394044
            Orig. end                         :: 416639
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            QGHB01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22595
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22595
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22595
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12595](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12595)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(441..455)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            980..1774
                     /locus_tag="C8D88_RS27080"
                     /old_locus_tag="C8D88_107386"
     CDS             980..1774
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (4-170). E-value: 4.7e-15. Score:
                     47.9. Matches aSDomain:
                     nrpspksdomains_C8D88_RS27080_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005459438.1"
                     /locus_tag="C8D88_RS27080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107386"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_211337476.1"
                     /transl_table=11
                     /translation="MNALAVVTGASSGIGYELAKVFADNGFDVVVVAEDERIDEAAAQL
                     RLRSGGVHVEPVIADLRTFEGVESLVARVRAMGRPVDVLAVNAGVGVGGDFLRDTSLGD
                     NLEVVDLNVRSAVHLAHRLIGDMVDRKEGKVLFTSSVAATAPGPFHSVYAASKAFLASF
                     AQGLREELRDTGVSVTTLMPGPTDTEFFDRAGMQDTKVATGDKDDPAQVAQQGFDALMK
                     GDDHVVAGSLMNKVQAIAGKVAPDPVKAKMMRTMTEPGSADS"
     aSDomain        992..1489
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_C8D88_RS27080_PKS_KR.1"
                     /evalue="4.70E-15"
                     /label="C8D88_RS27080_PKS_KR.1"
                     /locus_tag="C8D88_RS27080"
                     /protein_end="170"
                     /protein_start="4"
                     /score="47.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="AVVTGASSGIGYELAKVFADNGFDVVVVAEDERIDEAAAQLRLRS
                     GGVHVEPVIADLRTFEGVESLVARVRAMGRPVDVLAVNAGVGVGGDFLRDTSLGDNLEV
                     VDLNVRSAVHLAHRLIGDMVDRKEGKVLFTSSVAATAPGPFHSVYAASKAFLASFAQGL
                     REE"
     CDS_motif       1385..1474
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_C8D88_RS27080_0001"
                     /evalue="1.30E-04"
                     /label="PKSI-KR_m4"
                     /locus_tag="C8D88_RS27080"
                     /protein_end="165"
                     /protein_start="135"
                     /score="14.5"
                     /tool="antismash"
                     /translation="LFTSSVAATAPGPFHSVYAASKAFLASFAQ"
     gene            1791..1982
                     /locus_tag="C8D88_RS27085"
                     /old_locus_tag="C8D88_107387"
     CDS             1791..1982
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226108.1"
                     /locus_tag="C8D88_RS27085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107387"
                     /product="DUF2795 domain-containing protein"
                     /protein_id="WP_109638638.1"
                     /transl_table=11
                     /translation="MSQSNPIQIQKYLSGVDYPVSKRQLLEKARDNGAGQDVLTALEKL
                     PEREYNGPNAVSAEVSGA"
     gene            1979..2455
                     /locus_tag="C8D88_RS27090"
                     /old_locus_tag="C8D88_107388"
     CDS             1979..2455
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005443971.1"
                     /locus_tag="C8D88_RS27090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107388"
                     /product="DUF1360 domain-containing protein"
                     /protein_id="WP_109638639.1"
                     /transl_table=11
                     /translation="MRRIWQAYGEGRPLPGYLLAIGTYAALAGVVSAVGRLTGVRLPER
                     FSLGDTALVGVATHKASRLLTKEAVTSPLRAPFTRYEEPAGHAELKESPRSDDPARHAI
                     GELLTCPFCAGVWIASGLTAGLVFAPRVTRLVATALTAVAASDTLNLVYDKLKS"
     gene            complement(2450..3007)
                     /locus_tag="C8D88_RS27095"
                     /old_locus_tag="C8D88_107389"
     CDS             complement(2450..3007)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS27095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_107389"
                     /product="hypothetical protein"
                     /protein_id="WP_109638640.1"
                     /transl_table=11
                     /translation="MRNDRALHPRGVQLTGELTGTEPFPAAATVTARLSKGAGTGPGKP
                     DVLGLALRVPTASGDWDLLLSSTGTGQRTRLLPKFVRHWRDARLGTLAPYRYRDELLWF
                     MAVPDDGELPGRFTLHVSGRDAEWRRIADVTLHHEKPVTTPVAFDPVLNRPPEMEMAPH
                     WLAVLREQAYHGSRRGRHQPES"
     gene            3114..3782
                     /locus_tag="C8D88_RS27100"
                     /old_locus_tag="C8D88_107390"
     CDS             3114..3782
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015785511.1"
                     /locus_tag="C8D88_RS27100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107390"
                     /product="HemK2/MTQ2 family protein methyltransferase"
                     /protein_id="WP_109638717.1"
                     /transl_table=11
                     /translation="MRLLRAPGVYAPQDDTALLVEAMHAAAIPVGARVLDVGTGSGALA
                     IAAIRAGAAEVTGVDVSRRAVWTARVNAALRRMPLRVRLGNALEVVADEQFDLVLANPP
                     YVPAAGSCAARGPARAWDAGLDGRQLLDPLCARMFGLLAPGGVLLMVHSALCGVDTTLR
                     QLRDNGLKASIVQRRRVPFGPVMNGRIGFLERHGLIEPGQRHEELVVIRGDRPERSQPA
                     "
     gene            3751..3993
                     /locus_tag="C8D88_RS27105"
                     /old_locus_tag="C8D88_107391"
     CDS             3751..3993
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983838.1"
                     /locus_tag="C8D88_RS27105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107391"
                     /product="CDGSH iron-sulfur domain-containing protein"
                     /protein_id="WP_109638641.1"
                     /transl_table=11
                     /translation="MTGQNAPNRRERRVTVVPNGPVLVEGPVELVTEDGVTHTSDRFVV
                     AVCACRRSKRYPFCDTSHRRRVRSDDSSAAHDDSR"
     gene            complement(3915..4937)
                     /locus_tag="C8D88_RS27110"
                     /old_locus_tag="C8D88_107392"
     CDS             complement(3915..4937)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003063226.1"
                     /locus_tag="C8D88_RS27110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107392"
                     /product="iron-containing redox enzyme family protein"
                     /protein_id="WP_109638642.1"
                     /transl_table=11
                     /translation="MTSSTSGYENVVKLPSPRGPLSETVIDTLGGPPNGRSIPYTDADP
                     YGEDLTIALHVLYELHYCGFDGVHEAWEWDPELLKLRAHAETAFLAALRSDVDGGDDLD
                     AALDALLVEHLPGSGVSHHLRDHGTWDEMREYFAHRSVYHHKEADPHAWVIPRLRGTAK
                     AALVAVEFDEFGGGRADRMHSRLYADLLEGAGMSSDYLHYLDDVPAPAIAIVNMMSLFG
                     LHRSLRGALVGHFAAAEITTAPSAIRLAQALERLEADPRCVEFFTEHIEADAVHEQIMR
                     RDVIGSLLEQEPKLRADVVFGIQATELLEARLADHLLSSWAADESSLRTRLRWLVSQNG
                     "
     gene            complement(4912..5889)
                     /locus_tag="C8D88_RS27115"
                     /old_locus_tag="C8D88_107393"
     CDS             complement(4912..5889)
                     /GO_function="GO:0016879 - ligase activity, forming
                     carbon-nitrogen bonds [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1165: carboxylate-amine ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR02050.1"
                     /locus_tag="C8D88_RS27115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107393"
                     /product="YbdK family carboxylate-amine ligase"
                     /protein_id="WP_233439853.1"
                     /transl_table=11
                     /translation="MPQCADTVGVEEEFLLVDTASGRTAVRADAVLARVQDTDLTKFHA
                     ELASTQVEAATGPCTSVAELGQALRQARAMLAKAAEEAGLGLVSRGTPVKPSLQPIVSH
                     DNPRFRRVLDTYAGVVEHYEACGCHVHVGVPDRETGVRVLNHLRPWLPTLLALSANSAG
                     NGYASWRMVEQSRFPGSGVAPVFADAAGYDAHVARMVACGTLVDRAQSFWLARLSPKLP
                     TVEFRVADAAATVEDAMLQAALSRALVHTAVVADEPRPVRDDVCAAAVWAASRYGLDGA
                     GVDPWRECRVPATALLEALLEHVTPALAERGELELVHDLVDQRV"
     gene            complement(5873..6304)
                     /locus_tag="C8D88_RS27120"
                     /old_locus_tag="C8D88_107394"
     CDS             complement(5873..6304)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802001.1"
                     /locus_tag="C8D88_RS27120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107394"
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_109638644.1"
                     /transl_table=11
                     /translation="MVDVSTRTRVQQAALVVAAVFALVGVLGFIPGITTNYDQMTFAGH
                     ESGAMLLGIFMVSILHNIVHLLFGVAGFLAARSAAGARAFLIGGGAIYLVLWLYGLVID
                     KTSSANFVPLNTADDWLHFVLGLGMIGLGVALGRRAAVR"
     misc_feature    6350..6366
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.3"
                     /tool="antismash"
     misc_feature    complement(6371..6387)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 24.11"
                     /tool="antismash"
     gene            6398..6790
                     /locus_tag="C8D88_RS27125"
                     /old_locus_tag="C8D88_107395"
     CDS             6398..6790
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680782.1"
                     /locus_tag="C8D88_RS27125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107395"
                     /product="hypothetical protein"
                     /protein_id="WP_109638645.1"
                     /transl_table=11
                     /translation="MDEVTIQALGKLSAALETTERARGHLYSFHQLTGTADFMLDDAVA
                     LLRQAGHHEHADRVQGELLGRNVLPGRWTFEIVEEYDDTYYECFREVERAARDALADGR
                     RHDLEARLKQERQRLSAAVSYKSRPR"
     gene            complement(6806..9694)
                     /locus_tag="C8D88_RS27130"
                     /old_locus_tag="C8D88_107396"
     CDS             complement(6806..9694)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015804021.1"
                     /locus_tag="C8D88_RS27130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107396"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_109638646.1"
                     /transl_table=11
                     /translation="MQTRAPHVVGRDREVTALVEALDRTRAGRGGAIFLTGEAGIGKSR
                     LARYAAGHAYDAGVRVLKGRGTSIGPMVPFRPIAEALLALFRGEPPDDSALGPYKPVLG
                     TLIPEWHDHRSTTESVVVLAEAVLRLLASVARKTPCLLVLEDLHDADAETLAVIEYLAD
                     NLEDQPVLLLATIRTEPGNALELIHRIAQRGAAAQLDLRRLTRAEVERMTAACLESERI
                     PAELCARLWTDSAGNPFLVEELLHGMVSSGLLVSGARGWQVLGELKLPVPAAFVRSVAH
                     RIDRLGPQGREVLSIAAVLGHRFPLSVVQRVTGTGDRALLSHLHAGVAAQLVTPDEPAP
                     DWYAFRHPLTADALLAQLTPTERAELSRRAADAVEDLHPGLTGDWCPLVAKLRFDAGSP
                     AEAGLLFAEAGERALGNGAAGSAVTLLDRAQRLLTGEARADVLDSLLPALAETGEFERA
                     FELEREIADLSGLDGPRRAKLHTRLARVAYLAGRFTDGVEQVRAARSLLGAGAPDELTA
                     QLDVNSAYLTLNIPSADRIESAACLARKAADAAARAELPVVACEAWQLLGIIAREQDLD
                     EANRCFDKARALADAHQMPIQHIYALVRLAGNDWLASGCTAALGRVRDEACRAGAITVA
                     YNVDAIMALQHVLTGAYETAGEQIDSCLQATARLQFHALTRYLLMVKATLAAHRGNRQE
                     TDDATARFEEVAKGGAQEIPLCHGLARAFCALLEEDHALAAQELDAAEAKESQNPTTFH
                     LSGTHGIRVLLAVLDGRFGWSDYEVLAKSSAAGMRWNRQFAGLARAVLLGRDGRGAEAL
                     EAFESAQEAAALYPMARHLGLRLIAREASAWGDPVTWLRTAEEYFHEAGIPAVASACRG
                     LLRQAGAPVQQRRSGTDQVPKQLRGHGVTVREFEVFVLLADRMGNKAIGTRLHISPRTV
                     EKHVASLIAKTGQPDRESLSAYAAAVSYKSVR"
     gene            complement(9800..9988)
                     /locus_tag="C8D88_RS27135"
                     /old_locus_tag="C8D88_107397"
     CDS             complement(9800..9988)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS27135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_107397"
                     /product="hypothetical protein"
                     /protein_id="WP_109638647.1"
                     /transl_table=11
                     /translation="MNESLHRPAALPEPVEHVIGEMELAPKSSAGARARALAGLTLAAG
                     AFASLTPALSDTTVSVV"
     gene            complement(10001..12595)
                     /locus_tag="C8D88_RS27140"
                     /old_locus_tag="C8D88_107398"
     CDS             complement(10001..12595)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103770.1"
                     /locus_tag="C8D88_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107398"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_233439842.1"
                     /sec_met_domain="DUF4135 (E-value: 2.1e-103, bitscore:
                     341.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2e-17, bitscore: 57.7,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPVETSTSESWTAAFAHALRPLIDAARTEVAPPFDASFAEQLG
                     RRLVAIAARTLVLELHKARGTLAGDTGAQRFTSFTRTLDLPALFARYPVLARLLAQACE
                     QAVSAHHELSSRFTRDRPEIVRAIFGGRDPGTLASIETGRGDAHQQGRTVAVLTFESGD
                     RLVYRPRPVGLHEHFSAQLDWLSTRTGISFRSPRLLVRDGYGWLEFVSYEPCADVAGVA
                     EFYRRLGALLALLYAVDGTDMHYENLIACGDQPVLVDVETLFHPTPATSDDPAALALAR
                     SVHRTALLPHVLLGDNGVADVSGVGGDHGVLSPLNVVDWADAGTDRMRLVRRPRESSGA
                     SNRPVLGGVPAEPADYQDSLMAGFRAGYDAIVTGRDELLRLVRACADDEVRFVARATRQ
                     YAVLLDESTHPSVLADAMDRDLAFGVLVIDDPLLDRLVPFEVTDLWHGDVPLFTCRPSS
                     RDLWTTSGLRLPGMLPEPGLHAVERKIAAMSEVDRHDQQWVIAASLASRPRPVSHHSGG
                     ALPGHVAAVDPDPARLLVAACGIADQILAHAVTGRDRVNWLGLELVDDRHWTVQPLGAG
                     LSNGYTGVALFLAELGALTGAARYVDFARDAVRPLRSLLSSFAASPGLVAAVGGGFHGL
                     GGICYGLARLTPLLGLDPGLLSTAVSLMPLEDSSFSVVDGVAGSLAAMLAVGTPESLAL
                     ADHYASVLRGAICRANGFARGHAGIGWALRRYAATVCDESIDVAGQTFLESDAIDPTDT
                     GWCSGLAGAAMASDDDRLCTVLASREPLRDMSLCHGELGVVEALSARHPGAATRRTALL
                     LGALDEHGARCATPGGVPSPGLLTGLAGIGHGLLRQGFPVPSILLLEPVANR"
     CDS             complement(12592..12693)
                     /gene="allorf_406636_406737"
                     /locus_tag="allorf_406636_406737"
                     /protein_id="allorf_406636_406737"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRSPIFRSRPESSAESGGSAPMCSPHARARFCR"
     CDS_motif       complement(12640..12693)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRSPIFRSRPESSAESGG"
                     /locus_tag="allorf_406636_406737_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12592..12639)
                     /prepeptide="core"
                     /locus_tag="allorf_406636_406737_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.30"
                     /molecular_weight="1653.9"
                     /monoisotopic_mass="1652.8"
                     /core_sequence="SAPMCSPHARARFCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRSPIFRSRPESSAESGG"
                     /leader_location="[12639:12693](-)"
     gene            12751..13806
                     /locus_tag="C8D88_RS27145"
                     /old_locus_tag="C8D88_107399"
     CDS             12751..13806
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="C8D88_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107399"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_109638649.1"
                     /transl_table=11
                     /translation="MREFGELLRTHRIRVGLTQQQLADFAMVSVRAIRDLECGRTRSPR
                     AETVRLLADGLRLDDDSRANLREAGGRPAGPVSVAPPAPSSAIVGREAEQAALLDLFAD
                     GGRLVTITGVSGVGKTRLALEVVGALHFRLGWSVTWLPSSRTPQIDDGQDTVLVTDHLP
                     DTALLDRHPRLRVIVTSLAPAGIAGEHVFPLAPLADEAAVRLLVMNVRRVRPGFRQEAG
                     NSAALMGLVRELDGLPSALEFAAGWFMVYSPQHLLERLRTNPLDPTSAHLRDSLRLSLS
                     TLDEEERAALTRMAGRGEGQDDHVTRALSVRGLVRRAGRRYEVLNLVRAAVLEPVSGPH
                     SAGGVALTWPC"
     gene            complement(13803..14375)
                     /locus_tag="C8D88_RS27150"
                     /old_locus_tag="C8D88_107400"
     CDS             complement(13803..14375)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006801 - superoxide metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013672680.1"
                     /locus_tag="C8D88_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107400"
                     /product="superoxide dismutase family protein"
                     /protein_id="WP_109638650.1"
                     /transl_table=11
                     /translation="MRTTVAALVGAALLTGATACSGETPAAPAVKPVAETEVAGPAASG
                     DQPKGITYDVKRIPLGAKLSTGSSVAGGRTTVELKVSGLQPDTKYGSHVHTKPCGAKPA
                     DSGPHYQNEKDPVAPSVDPKYANAQNEIWLDFTTDAQGAATATATVNWEFRKGEANAVI
                     IHATHSSTEHGKAGTAGDRLACLTAQF"
     misc_feature    complement(14370..14385)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.35"
                     /tool="antismash"
     gene            complement(14389..16782)
                     /locus_tag="C8D88_RS27155"
                     /old_locus_tag="C8D88_107401"
     CDS             complement(14389..16782)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_107401"
                     /product="hypothetical protein"
                     /protein_id="WP_109638651.1"
                     /transl_table=11
                     /translation="MSPRTLELRIHGVNNTPPDAMLALPDHAVEQFRGDRFGSFWRPKP
                     DKVAELPPVHAGRVPGGVRREAYSWGGMARSSPGVPGSGVPSVLANALGRIGWALLLPF
                     GLANVAYWSRRLPDDSMPATRRMVWWNAGRGAASTRLFGLGLTVLLVLAVCEVAIDVYA
                     IQCSLPGTTCKRLPEFMDLLGDPARHVRVLAASAVPVLLLFGLLALTSLSRSRYEMATM
                     RRTPVRRPGVMLSRSSMWEGSPRIRRLTRLHLAAGCCVVTLVTSAQQLQHAFFLVLTVF
                     AAGLLAVVVGRVVVTATDCPDVPSTEKGGLWSWLLVVAAVLVLVVHGFGLYGFAPVFEG
                     PLWLASWGPPVVTVALLGSVLAAWSWRRNDAKGPLALLVLFVAFMVATYWFPLAWIGAV
                     VAGGVLAWRARPRSGDEWQAWRGAGPGVLLGLSLTTSVMLAAVLVLTFRGWVGTGLRVP
                     SFYSWFSAAFAVALVPLVLLVIAQALALLSRLTKPALLDDEADVLVVRVRHVVAVTHRA
                     ENVVGVLSTLGVLALILTCYLTFASPSWTGWWGVTWVVGKGDWVTGLAGVAVISSFVGA
                     GMLTNRRPLGLLWDLMCFLPRTAHPFAPPCYAERAVPEIADRTREFLDESPDNRVVLSA
                     HSLGAVLAVAALYALPEGYLERTQLLTYGVQLRPYFGRIFPELLGPAVLGTPEVRAGAM
                     FSRDPWRRSPGATPDRGLSTLLGASWINLWRRTDYLGFPVHGWESNPLDRRASETNGSP
                     DKVETHGGYHLCAAYQDAFRDLVSIDLNRSPDGGRGGGGNLERS"
     gene            16901..18778
                     /locus_tag="C8D88_RS27160"
                     /old_locus_tag="C8D88_107402"
     CDS             16901..18778
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015531.5"
                     /locus_tag="C8D88_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107402"
                     /product="S41 family peptidase"
                     /protein_id="WP_109638652.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 2.4e-13, bitscore:
                     44.7, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTAHPNVANSVGLAEFLATAGSLTLAQRKLIVDQALILLEQNY
                     AHLPLKVAMHAVNPVQRLRVLRARLERQTDATAEPEWQFHRELSSTFHSVRDLHTNYLL
                     PAPFAGKIAFLPFQLERCFDADGTEQYLVARTVAGFDGIAVGAEVTHWNGTPISRAVAL
                     NGAIFAGSNTAANLARGLESLTLRPLVIQLPPDEDWVVVTYRNENGASEDIRVDWQVTD
                     NLPPMTDTDSLSPAAAAQGVDLDSDEKARAKKLLHAPKVVQAEAAGGAVAMSSQDVPTT
                     MPGVFRARPVTTPSGEFGHLRIFTFSVDDPDAFLKEFVRLAALLPQNGLIVDVRDNGGG
                     HIFASEFLLQTMTPRRIEPEPVQFLSTPLNLRICRRHADDPTGQIDLGPWFPSLDSSTE
                     TGQAFSCAHTITPVAGANAVGQTYHGPVVLITDARCYSATDIFAAGWADHDLGPILGVD
                     DNTGAGGANVWTHGLLMTLLKIPAPGDTESPYKSLPNKANMRVSIRRTLRVGKLAGTPV
                     EDLGVRPTHQHKVTRADLLQGNVDLLAKAGSLLAALPVRRLGVAVAGTTVSLDTVNLDR
                     VDIYVDGRPATSLDVTDGAHTATLSATGNEVRVEGFADGQLVAARKVTG"
     gene            complement(18832..19401)
                     /locus_tag="C8D88_RS27165"
                     /old_locus_tag="C8D88_107403"
     CDS             complement(18832..19401)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_107403"
                     /product="hypothetical protein"
                     /protein_id="WP_146231663.1"
                     /transl_table=11
                     /translation="MRKVMAAALAGAALLGLAGTASASTDYPWPPKDVTPVHKTKAELQ
                     KQADEFSARQEKTYPRAFRGAQNVEPGPWGGEAAGVFDGMQYMGNTVTFTYKGQDVTTY
                     TQVNAPGMHEWSPKEYCEKYATCTSTVSDHKGGVTVFSKDERFGIVEARNFRPNGEVVW
                     VQSWTQGTEAQLGALATDRAFTFTKK"
     gene            complement(19496..19753)
                     /locus_tag="C8D88_RS27170"
                     /old_locus_tag="C8D88_107404"
     CDS             complement(19496..19753)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C8D88_RS27170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="C8D88_107404"
                     /product="hypothetical protein"
                     /protein_id="WP_146231664.1"
                     /transl_table=11
                     /translation="MITQVNAPGFVSDSPEEFCAQTTCTGTVSDNQGGVIVFSEDDSYD
                     DRSAHNFRPNGEVVFTQGSRQDDPALLGAVASDRAYTFTR"
     misc_feature    complement(19736..19751)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     CDS             complement(19750..19926)
                     /gene="allorf_413794_413970"
                     /locus_tag="allorf_413794_413970"
                     /protein_id="allorf_413794_413970"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MALAGRGCNQPAVRERVSPRKRELTDGIHMRKAMAAALTGLALAG
                     LAGTARSRVCGPV"
     CDS_motif       complement(19816..19926)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MALAGRGCNQPAVRERVSPRKRELTDGIHMRKAMAAA"
                     /locus_tag="allorf_413794_413970_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(19750..19815)
                     /prepeptide="core"
                     /locus_tag="allorf_413794_413970_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.70"
                     /molecular_weight="1929.3"
                     /monoisotopic_mass="1928.1"
                     /core_sequence="LTGLALAGLAGTARSRVCGPV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALAGRGCNQPAVRERVSPRKRELTDGIHMRKAMAAA"
                     /leader_location="[19815:19926](-)"
                     /alternative_weights="1947.3"
                     /alternative_weights="1965.3"
     gene            complement(19917..20843)
                     /locus_tag="C8D88_RS27175"
                     /old_locus_tag="C8D88_107405"
     CDS             complement(19917..20843)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="C8D88_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="C8D88_107405"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_170155076.1"
                     /transl_table=11
                     /translation="MFGHLGVSPELSALYELLVTGGSRTTAEIGVAPELLTRLHELGVV
                     RHLPGDVWQAVAPDLAVEALIAAREEQNRRARADVGPLMELYLRNRDEEQADNAFVEVV
                     SGLGAVRELWNTLLNGAREEVCVLDQPPYVTPLGEHVALEDATRQRDVKWRVVYDRSAV
                     DLPGRVTEIIELVAAGERARVTPTLPFKLAVIDTHAAVLPVANGDVVDKVLLIRPSALL
                     DVLRSTFELYWDKGIPFSPGGIYAAAADVDPNLLGLLAAGLTDESIARQLGLAPRTVQR
                     RVRQLMDRCGAQTRFQAGVQAMRRGWL"
     CDS             20851..21030
                     /gene="allorf_414895_415074"
                     /locus_tag="allorf_414895_415074"
                     /protein_id="allorf_414895_415074"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCAIQRNTPVVNTSVSLFGRLKNCLRRSAAAYGPRHLRSRFRTLT
                     PSTACGGPVWKDLS"
     CDS_motif       20851..20949
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MCAIQRNTPVVNTSVSLFGRLKNCLRRSAAAYG"
                     /locus_tag="allorf_414895_415074_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       20950..21030
                     /prepeptide="core"
                     /locus_tag="allorf_414895_415074_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.50"
                     /molecular_weight="2831.2"
                     /monoisotopic_mass="2829.6"
                     /core_sequence="PRHLRSRFRTLTPSTACGGPVWKDLS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCAIQRNTPVVNTSVSLFGRLKNCLRRSAAAYG"
                     /leader_location="[20850:20949](+)"
                     /alternative_weights="2849.3"
                     /alternative_weights="2867.3"
                     /alternative_weights="2885.3"
                     /alternative_weights="2903.3"
                     /alternative_weights="2921.3"
ORIGIN
        1 cgagccgtcg ggctggatca cgtcgacctt gcccttgccc tgctgacccg ccactgcctc
       61 gaccggaacg accagcgcct gcgccgactt gccggtggtg acctcgatcg acgcgctggc
      121 gccgttgatc atctgcacgt ccgccggtcc ggtgcacacg atgcgcaggc ccgtggagga
      181 gctcggctgc tgcggctgtt ccggctgctt gggctgttcg ggctgcttgg gctggtccgt
      241 cggcgggttc ttggtgtccg gggtcggcgt gggcttctcc gggatggtgc cctgcggcag
      301 cgcggcgatg gtgccgagca cggtgcacgg gaacgggccg ggcccgttct tgatctgcac
      361 ggtgacgtcg gtcagcgcgc cgctgatctt gtacgcctgg gcgccgtcga tgtcgcccac
      421 gatcgcgtag ccgacgtgct tggccgacgc gatcggcatg cccgccgtca ccgtcgcctt
      481 gtcgtcgacg agcctgccgc cgaacgtggc accggccggg atctcgacgt agttcggcgc
      541 cccgtccttc cacaccgtcg cgaccctggt gggcttggtc ggagtgccgt tgggcgcctg
      601 caggtcgaag taccgcacct gaccggcgac cggcgcgacg agcccgaacg tcgggttcat
      661 ctcgaccttg ccggagatgc tgagcttggt ggtgaggtcc tgcctggtcg gcttgacctt
      721 ggtcatcgtc gtgccgcgcg gcgccagctc cgggttggtc ttctccggac ctgacggact
      781 gcacgccgcc acggcgaccg tgaccagcgc gcacagcggc gcgagaacga ttttgcgcac
      841 gaatgtcccc catgtcgttt cgaccaacct accgataagg acacccgaag agacggggag
      901 gttgcatcgg actttcggcc gatgccgcat cgacctggtg gccacgggta tccgggtggt
      961 gaccggaagg agaggacctg tgaatgcgct tgccgtggtg accggtgcgt cgagtggaat
     1021 aggttacgag ctcgcgaaag ttttcgcgga caacggcttc gacgtggtgg tcgtggctga
     1081 ggacgaaagg atcgacgagg cggccgcgca actgaggctg cgcagtggcg gtgtgcacgt
     1141 cgaaccggtg atcgccgacc tgcggacctt cgagggcgtg gagtcgctcg tcgcgcgtgt
     1201 tcgcgcgatg ggacgcccgg tcgacgtgct cgcggtgaac gcgggcgtcg gcgtcggcgg
     1261 tgacttcctg cgcgacacct cgctcggcga caacctggag gtcgtggacc tgaacgtgcg
     1321 ctcggccgtg cacctggccc atcggctgat cggcgacatg gtggaccgca aggagggcaa
     1381 ggtgctcttc acgtcctcgg tggccgcgac cgcgcccggc ccgttccact cggtctacgc
     1441 ggcctcgaag gcgtttctgg cgtcgttcgc gcaggggctg agggaagagc tgcgtgatac
     1501 cggggtctcc gtgacgacgc tcatgccggg accgaccgac accgagttct tcgaccgtgc
     1561 gggcatgcag gacaccaagg tcgctacggg ggacaaggac gaccccgcgc aggtcgccca
     1621 gcagggcttc gacgcgctga tgaagggtga cgaccacgtg gttgcgggct cgttgatgaa
     1681 caaggtccag gcgatcgccg ggaaggtcgc accggacccg gtgaaggcga agatgatgcg
     1741 cacgatgaca gagcctggtt cggccgactc ctgatgggta ctcgcgcgcc atgagccaat
     1801 cgaatcccat tcagatccag aagtacctct ccggcgtgga ctacccggtg agcaagcggc
     1861 agctgctgga gaaggcccgc gacaacgggg ccggtcagga cgtcctgacc gcgctcgaga
     1921 agctgccgga acgcgagtac aacggcccga acgccgtcag cgcggaggtt tccggagcgt
     1981 gaggcggatc tggcaggcgt acggcgaggg caggccgctg cccggctacc tcctcgccat
     2041 cggcacatac gcggctctgg ccggcgtcgt atcggcggtc gggcgcctca cgggcgtccg
     2101 gctgcccgaa cggttctcgc tgggcgacac ggcgctcgtc ggtgtcgcga cgcacaaggc
     2161 gagccggttg ctcaccaaag aggcggtgac gagcccgctg cgggctccgt tcacccgtta
     2221 cgaggaaccg gcggggcacg cggaactcaa ggagtcgccc cggtcggacg atccggcgcg
     2281 gcacgcgatc ggtgagctgc tcacgtgccc gttctgcgcc ggcgtgtgga tcgcgagcgg
     2341 gctcaccgcg ggtctcgtgt tcgcgccacg ggtcacgcgg ctggtggcga cggcgctcac
     2401 ggccgtcgcg gcgtccgaca cgctgaacct cgtgtacgac aagctgaagt catgactccg
     2461 gctggtggcg gccgcgccgg ctcccgtggt aggcctgctc ccgcagcacg gcgagccagt
     2521 gcggcgccat ctccatctcc ggcggccggt tgagcacggg gtcgaacgcc accggggtcg
     2581 tcaccggctt ctcgtgatgg agcgtcacgt ccgcgattcg gcgccactcg gcgtccctgc
     2641 ccgacacgtg gagcgtgaac cggccgggca gttcgccgtc gtccggcacg gccatgaacc
     2701 acagcagctc gtcgcggtac cggtagggcg ccagcgtgcc gagcctggcg tcccgccagt
     2761 gccgcacgaa cttcggcagc aagcgcgtcc gctggccggt gccggtgctg gacagcagca
     2821 ggtcccagtc accggacgcg gtcggcaccc gcaacgcgag gccgagcacg tccggttttc
     2881 ccggtccggt gcccgctccc ttggacaggc gcgcggtcac ggtggccgcc gcgggaaacg
     2941 gttcggtgcc ggtcagctca ccggtcagct ggacgccgcg cggatgcagc gcgcggtcgt
     3001 tcctcacccg ggcgatcagg cggaaaacag tggacagcac atcccggtgt acccgtggga
     3061 aacaccggga aacgcggtgt ttcaaggtct taccgcgagc cgattcccgg atggtgaggc
     3121 tgctgagagc accgggcgtg tacgcgcccc aggacgacac cgcgcttctc gtcgaggcca
     3181 tgcacgccgc ggcgatcccg gtgggcgcgc gtgtgctgga cgtcggcacc ggcagcggag
     3241 cgctggcgat cgcggcgatc cgcgcgggag ccgccgaagt gaccggtgtg gacgtgtcgc
     3301 ggcgcgcggt gtggacggcg cgggtcaacg cggcgctgcg gcggatgccg ttgcgcgtgc
     3361 ggctcggcaa cgcgctggag gtcgtggcgg acgagcagtt cgacctggtg ctcgccaacc
     3421 cgccgtacgt gccggccgcc ggttcctgtg cggcgcgcgg gcccgcgcgg gcgtgggacg
     3481 cggggctgga cggacgacag ctgctggacc cgttgtgcgc caggatgttc ggccttctgg
     3541 cgccgggcgg cgtgctgctg atggttcatt ccgcactgtg cggagtggac acgacgttgc
     3601 ggcagttgcg ggacaacggc ctgaaggcct cgatcgtgca acgccgccgg gtgccgttcg
     3661 ggcccgtcat gaacggcagg atcggcttcc tggagcggca cggcctgatc gagccgggcc
     3721 agcggcacga ggaactggtg gtgatccgcg gtgacaggcc agaacgctcc caaccggcgt
     3781 gagcgcaggg tgacggtggt gccgaacggg ccggtgctcg tcgagggacc ggtcgagctc
     3841 gtcaccgagg acggcgtgac gcacaccagc gaccggttcg tggtcgcggt gtgcgcgtgc
     3901 cgccgcagca agcgctaccc gttctgcgac accagccatc gcaggcgcgt gcgcagcgac
     3961 gactcgtcgg cggcccacga cgacagcagg tgatcggcga ggcgtgcttc gagcagttcc
     4021 gtcgcctgga tgccgaacac cacgtcggcg cgcagcttcg gctcctgctc cagcagcgag
     4081 ccgatgacgt cacgccgcat gatctgctcg tgcacggcgt cggcctcgat gtgctcggtg
     4141 aagaactcga cgcagcgcgg gtcggcctcc aggcgttcga gcgcctgggc caggcggatc
     4201 gcgctcgggg cggtggtgat ctccgcggcg gcgaagtggc cgaccagcgc gccgcgcaac
     4261 gaccggtgca ggccgaagag cgacatcatg ttgacgatcg cgattgccgg tgccggcacg
     4321 tcgtcgaggt agtgcaggta gtccgaggac ataccggcgc cctcgagcag gtcggcgtag
     4381 aggcgggagt gcatccggtc ggcccggccg ccgccgaact cgtcgaactc caccgcgacc
     4441 agtgccgcct tcgccgtgcc gcgcagcctc gggatcaccc acgcgtgcgg gtcggcctcc
     4501 ttgtggtggt acaccgagcg atgcgcgaag tactcgcgca tctcgtccca ggtcccgtgg
     4561 tcccgcaggt gatgtgacac cccgctgccg gggaggtgct cgaccagcaa cgcgtccagc
     4621 gccgcgtcga ggtcgtcccc gccgtccaca tcggaccgca acgccgccag gaacgccgtt
     4681 tcggcatggg cgcggagctt cagcagctcc ggatcccact cccaggcctc gtgcacgccg
     4741 tcgaaaccgc agtagtgcag ctcgtacagc acgtgcaggg cgatggtgag gtcctcgccg
     4801 tacgggtcgg cgtcggtgta cgggatcgaa cggccgttcg gcggaccgcc caaggtgtcg
     4861 atgacggtct cggacagcgg cccgcggggc gagggaagct tcaccacgtt ctcatacccg
     4921 ctggtcgacg aggtcatgca cgagctcgag ctcgccacgt tccgccaacg ccggtgtgac
     4981 atgctccagc agtgcctcca gcagcgctgt cgcgggcacc cggcactccc gccacggatc
     5041 cacccccgcg ccgtccaagc cgtaccggga agccgcccag acggccgctg cgcacacgtc
     5101 gtcacgcacc gggcgtggtt catcggccac gaccgccgtg tgcacgagag cgcgagacag
     5161 agccgcttgc agcatcgcgt cctcgacggt ggccgccgcg tccgccacgc ggaactccac
     5221 ggtgggcagc ttcggggaca gccgggcgag ccagaacgac tgggcgcggt ccaccagggt
     5281 gccgcacgcg accatgcggg cgacgtgcgc gtcgtagccg gcggcgtccg cgaacaccgg
     5341 ggccaccccg gaaccgggaa agcgggactg ctcgaccatg cgccagctcg cgtagccgtt
     5401 gccggcggag ttcgccgaca gcgccagcaa cgtcggcagc cacggccgga ggtggttgag
     5461 gacgcgcacc ccggtctccc ggtcgggcac gccgacgtgc acgtggcagc cgcaggcctc
     5521 gtagtgctcg acgacacccg cgtaggtgtc gagaacccgg cggaaccgcg ggttgtcgtg
     5581 cgacacgatc ggctgcagcg acggtttcac cggcgtgcca cgggaaacca gcccgaggcc
     5641 ggcctcctcg gccgccttcg cgagcatcgc acgcgcctgc cggagcgcct ggcccagctc
     5701 ggcgacgctc gtgcacggac cggtcgccgc ctccacctgc gtgctcgcga gctcggcgtg
     5761 gaacttcgtc aggtccgtgt cctgcacgcg cgccagcacg gcgtccgccc gtaccgcggt
     5821 acgtccggac gccgtgtcga cgagcaggaa ctcttcttct acgccaacgg tgtcagcgca
     5881 ctgcggcacg ccggccaagc gcgactccca atccgatcat gccgagaccg aggacgaagt
     5941 gcagccagtc gtccgcggtg ttgagcggca cgaagttggc ggagctggtc ttgtcgatca
     6001 cgagtccgta cagccacagc acgaggtaga tcgcgccgcc gccgatcagg aaggctcgcg
     6061 caccggcggc cgagcgtgcg gccaggaagc ccgcgacgcc gaacagcaag tgcacgatgt
     6121 tgtgcagaat cgacaccatg aagatcccga gcagcatggc accggactca tgaccggcga
     6181 aggtcatctg gtcgtagttc gtggtgatgc ccgggatgaa gcccagcact ccgacgagtg
     6241 cgaacacggc cgcgacgacc agggctgcct gctggacccg cgtgcgggtg gagacgtcga
     6301 ccatcgaact cacctcgtgg tttggtcgtg aacgtggtcg atcgacgggc tacccggcgg
     6361 gggtagacgc aaaccctcgg cgggtattcg tgtcggcatg gacgaggtaa cgatccaggc
     6421 gctcggcaag ctcagcgcgg ccctggagac caccgaacgg gcacgcggcc acctctactc
     6481 gttccaccag ctcaccggca cggcggactt catgctcgac gatgcggtcg cgctgctgcg
     6541 ccaggccggc caccacgagc acgcggaccg cgtgcagggg gagctgctcg gcaggaacgt
     6601 gctgccggga cggtggacct tcgagatcgt cgaggagtac gacgacacgt actacgagtg
     6661 cttccgcgag gtcgagcgcg ccgccaggga cgccttggcg gacggcaggc gccacgacct
     6721 cgaagcgcgc ctcaaacagg aacgtcagcg gctcagcgcg gccgtgtcct acaagtctcg
     6781 tccgcgatag tcgcgtccga gaggctcatc gaacggactt gtaggacacg gccgccgcgt
     6841 acgccgacaa ggactcccgg tccggctgac ccgtcttcgc gatgagcgag gcgacgtgct
     6901 tctccaccgt gcgcggcgag atgtgcaggc gggtgccgat ggccttgttg cccatccggt
     6961 cggcgagcag cacgaagacc tcgaactcgc ggaccgtcac accgtgcccg cgcagctgtt
     7021 tcggcacctg gtccgtgccg ctgcggcgtt gctgcaccgg cgcgcccgcc tgccgcagca
     7081 ggccccggca cgccgacgcc accgccggga tccccgcctc gtggaagtac tcctccgcgg
     7141 tgcgcagcca cgtcaccgga tcaccccacg ccgaggcctc ccgcgcgatc agccgcagtc
     7201 ccagatgccg tgccatgggg tagagggcag cggcctcctg ggcgctctcg aacgcttcca
     7261 gcgcttcggc gcccctgccg tcgcggccga gcaggacggc gcgggcgagg ccggcgaact
     7321 ggcggttcca gcgcatgccg gcggcactcg acttcgccag cacctcgtag tcggaccagc
     7381 cgaagcggcc gtccagcacc gcgaggagca cccggatgcc gtgcgtgccg gagaggtgga
     7441 acgtggtggg gttctgcgac tccttcgcct cggcggcgtc gagctcctgc gccgccagcg
     7501 cgtggtcctc ttcgagcagg gcgcagaacg cgcgcgcaag cccgtggcac agcgggattt
     7561 cctgcgcgcc gcccttcgcc acctcctcga acctcgcggt ggcgtcgtcg gtctcctgcc
     7621 ggttgccgcg gtgcgcggcg agcgttgcct tcaccatcag cagatagcgg gtcagcgcgt
     7681 ggaactgcag ccgcgcggtg gcctgcaggc agctgtcgat ctgctcaccg gccgtctcgt
     7741 aggcgccggt cagcacgtgt tgcaacgcca tgatggcgtc gacgttgtac gccacggtga
     7801 tcgcgcccgc ccggcacgcc tcgtcgcgca cccggccgag cgccgccgtg cagccggacg
     7861 cgagccagtc gttgcccgcc aggcgaacca gcgcgtagat gtgctggatc ggcatctggt
     7921 gcgcgtccgc gagcgcgcgg gccttgtcga agcacctgtt ggcctcgtcg aggtcctgct
     7981 cgcgcgcgat gatgccgagc agctgccacg cctcgcacgc caccaccgga agctccgccc
     8041 gtgccgccgc gtccgccgcc ttcctggcga ggcacgcagc ggactcgatc cggtcggcgc
     8101 tcgggatgtt cagcgtgagg tacgcagagt tgacgtccag ctgggcggtc agctcgtccg
     8161 gcgccccggc gccgagcagt gagcgggcgg cgcggacctg ttccactccg tcggtgaacc
     8221 tgcccgccag gtaggcgacc cgcgcgagtc gtgtgtggag cttcgcgcgg cgcggcccgt
     8281 ccaggccgct gagatccgcg atctccctct ccagctcgaa ggcgcgttcg aactcgcccg
     8341 tctccgccag cgcgggcagg agactgtcga gcacgtcggc gcgcgcctca ccggtgagca
     8401 gccgctgcgc ccggtcgagc aacgtgacgg ccgaccccgc cgcgccgttg cccagcgcgc
     8461 gctcaccggc ctcggcgaac agcagtcccg cctcggcagg cgatccggcg tcgaacctga
     8521 gcttcgcgac gagcgggcac cagtcgccgg tcaggccggg gtgcagatcc tcgaccgcgt
     8581 ccgccgcacg cctggacagt tccgcacgtt cggtgggcgt gagctgggcg agcaacgcgt
     8641 ccgcggtgag cggatggcgg aacgcgtacc agtccggtgc gggctcgtcg ggtgtcacga
     8701 gctgcgcggc gaccccggcg tgcagatgac tcagcagcgc ccggtcgccg gtgccggtca
     8761 cccgctgcac caccgagagc gggaaccggt ggcccagcac cgcggcgatg gacagcacct
     8821 cacggccctg cggccccagc cggtcgatgc ggtgggcgac gctgcggacg aacgccgccg
     8881 gcaccggcag cttgagctcg ccgagcacct gccagccccg cgcgccggag acgagcaggc
     8941 cactgctcac catgccgtgc agcagttcct cgacgaggaa cgggtttccg gcgctgtccg
     9001 tccacaagcg agcgcacagc tccgccggga tccgctcgct ctccaggcag gcagcggtca
     9061 tccgctcgac ctccgcccgc gtcagcctgc gcaggtccag ctgggccgcc gcgccgcgct
     9121 gcgcgatccg gtggatcagc tccagcgcgt tgcccggctc ggtgcggatc gtggcgagca
     9181 gcagaaccgg ctggtcctcc aggttgtccg ccaggtactc gatgaccgcg agcgtctcgg
     9241 cgtcggcgtc gtgcaggtcc tccagcacca gcaggcacgg ggtcttgcgc gcgacgctcg
     9301 ccagcagcct gagcaccgcc tccgccagca ccaccacgga ttcggttgtg gaccggtggt
     9361 cgtgccactc cgggatcagc gtgcccagca ccggtttgta ggggccgagc gcggagtcgt
     9421 cgggcggttc accgcggaac agggcgagca gggcttcggc gatcgggcgg aacggcacca
     9481 tcgggccgat gctcgtgccg cgacccttga gcactctgac gcccgcgtcg taggcgtggc
     9541 cggcggcgta ccgggcgagc cgcgacttgc cgataccggc ctcgccggtc aggaagatcg
     9601 cgccaccccg gccggcgcgt gtgcgatcga gtgcctccac gagagccgtg acctctcgat
     9661 ctcggccgac cacgtggggc gctcgggtct gcatggctgg accttaacgg cctcgtgagg
     9721 ccgtccggat cggctgctca ggcgtaattc cggggcaatg gggccgggca ccgcccggcc
     9781 cctccaccgg tttcgggcct cacaccacgc tgacggtcgt gtccgacagc gcgggggtga
     9841 gggacgcgaa ggcacccgcc gcgagtgtca gtccggccag ggctcgggct ctcgcaccgg
     9901 cggacgactt cggcgcgagc tccatttccc cgatcacgtg ctcgaccggc tctggcaggg
     9961 cggccgggcg gtgcagggac tcgttcatcg gatgtactcc tcatcggttg gcgacaggtt
    10021 cgagcagcag gatcgagggc accggaaacc cttggcgcag caggccgtgg ccgatgccgg
    10081 ccaggccggt gagcaggccc ggtgacggaa cgccgccggg ggtggcgcag cgggcgccgt
    10141 gttcgtccag tgctcccagc aacagcgccg tgcggcgggt cgcggcgccg gggtggcggg
    10201 cggaaagcgc ttcgacgacg ccgagttcgc cgtggcagag actcatgtcc cgcaacggct
    10261 ccctggacgc gagcacggtg cacaggcggt cgtcgtcgct tgccatggcg gcgccggcca
    10321 ggccggagca ccagcctgtg tcggtggggt cgatggcgtc gctctccagg aaggtttgtc
    10381 ctgccacatc aattgactcg tcacaaaccg ttgccgcgta acgccgcaga gcccatccga
    10441 ttcccgcatg gccgcgggcg aacccattcg cccggcaaat cgcgccacgt agaaccgatg
    10501 cgtagtgatc ggccagagcc agcgactccg gcgtgcccac ggcgagcatc gcggcgaggg
    10561 atcccgcgac accgtccacc acgctgaacg acgagtcctc caacggcatc aacgacaccg
    10621 ctgtcgaaag caggccgggg tcgaggccga gcaacggcgt caggcgcgcc aggccgtagc
    10681 agatcccgcc caggccgtgg aacccgccgc ccaccgccgc gaccagcccg ggcgacgcgg
    10741 cgaaggagga gagcaacgac cgcaacgggc ggacggcgtc ccgcgcgaag tcgacgtacc
    10801 gggcggcgcc ggtcagcgca cccagttcgg cgaggaacag tgcgacacct gtgtagccgt
    10861 tggacaaacc agcgccgagc ggctgcacgg tccagtgtcg gtcgtcgacc agctcgagcc
    10921 ccagccagtt cacccggtcc cggcccgtca cggcgtgcgc gaggatctgg tccgcgatcc
    10981 cgcacgcggc caccaggagc cgcgccggat cggggtccac cgcggcgacg tggccgggca
    11041 gtgcgccgcc gctgtgatgg gacaccggcc gcggccggga cgccagcgac gccgcgatca
    11101 cccactgctg gtcgtgccgg tcgacctcgc tcatcgccgc gatcttgcgt tcgacggcgt
    11161 gcagcccggg ctccggcagc atccccggca gccggagccc ggacgtggtc cacaggtcgc
    11221 gcgacgacgg ccggcacgtg aacagcggca cgtcaccgtg ccacaggtcg gtgacctcga
    11281 acggcaccag ccggtcgagc aacgggtcgt cgatgaccag cacgccgaac gccagatcgc
    11341 ggtccatcgc gtcggcgagc acgctcggat gggtcgactc gtccagcaac acggcgtact
    11401 gacgggtcgc acgcgccacg aaccgcacct cgtcgtcggc acacgcgcga accagccgca
    11461 gcagctcgtc cctgcccgtc acgatcgcgt cgtagcccgc gcggaacccg gccatcagcg
    11521 agtcctggta gtcggctggc tcggcgggca caccacccag caccggccgg ttcgacgccc
    11581 ctgacgactc acgaggacgc cgcacgagcc gcatccggtc cgttccggcg tcggcccagt
    11641 cgacgacgtt caacggcgac aacacgccgt ggtcgccgcc cacaccggac acgtccgcga
    11701 cgccgttgtc gcccagcagc acgtggggga gcagcgccgt gcggtgcacg gacctggcca
    11761 gcgccagcgc ggccggatcg tcggacgtcg ccggcgtcgg gtggaacagc gtctcgacgt
    11821 ccaccagcac cggctggtcg ccacacgcga tgaggttctc gtagtgcatg tccgtgccgt
    11881 cgaccgcgta gagcagggcc agcaacgccc ccagtcgccg gtagaactcc gccacgccgg
    11941 ccacgtccgc gcacggctcg taactcacga actccagcca cccgtagccg tcgcggacga
    12001 gcagccgcgg cgagcggaag ctgattcccg ttcgcgtgga aagccagtcg agctgggcgg
    12061 agaagtgctc gtgcaacccg accgggcgcg gccggtagac cagccggtcc ccggactcga
    12121 aggtcagcac cgcgaccgtg cggccctgct ggtgcgcgtc gcccctgccc gtctcgatcg
    12181 acgccagcgt gccgggatcc cgcccgccga agatcgcccg cacgatctcc gggcgatcac
    12241 gggtgaagcg cgacgacagc tcgtgatggg cggaaacggc ctgttcgcag gcctgcgcga
    12301 gcaaccgcgc cagcaccggg tacctggcga acaacgccgg caggtccaag gtccgcgtga
    12361 aggaggtgaa ccgctgcgcg ccggtgtccc cggccagggt gccacgtgcc ttgtgcagct
    12421 ccagcaccag cgtgcgggcc gcgatcgcca ccaggcggcg gccgagctgc tcggcgaacg
    12481 aggcgtcgaa cggcggcgcg acctcggtgc gggcggcgtc gatcagcggg cgcaacgcgt
    12541 gggcgaaagc cgccgtccag ctctcgctgg tgctggtctc caccggtgag gtcaccggca
    12601 gaacctcgca cgcgcgtgcg gagagcacat gggggccgag cccccagatt ctgcgctgga
    12661 ctccgggcgg gacctgaata tgggggaccg caccccatgt tccgccgctc cacccgcctc
    12721 cagactcggg gaccgaggga gggatcgggc atgagggagt tcggggaact actgcgcacg
    12781 caccgcatcc gggtcgggct cacccagcag cagctggccg acttcgcgat ggtgagcgtg
    12841 cgggccatcc gcgacctgga gtgcggccgc acgaggtcac cgcgcgccga gacggtgcgc
    12901 ctgctcgcgg acgggctccg gctggacgac gacagccgcg cgaacctgcg ggaagccggt
    12961 ggccggccgg cgggaccggt gtcggtggcg ccgcccgcgc cgtcgtcggc gatcgtgggc
    13021 cgcgaggcgg agcaggccgc gctgctcgac ctgttcgccg acggagggcg cctggtcacg
    13081 atcacgggtg tcagcggggt cggcaagacg cggctcgcgc tggaggtggt gggtgcgctg
    13141 cacttccggc tcggctggtc ggtgacctgg ctgccgtcct cgcgcacacc gcagatcgac
    13201 gacggccagg acaccgtgct cgtcaccgac cacctccccg acacggcgtt gctggaccgc
    13261 cacccgaggc tgcgggtcat cgtcacctcg ctggcaccgg ccgggatcgc gggtgagcac
    13321 gtcttcccgc tggcgccact ggccgacgag gccgcggtgc ggctgctggt gatgaacgtg
    13381 cggcgggtgc ggccggggtt ccggcaggag gccgggaact ccgcggcgct gatgggcctc
    13441 gtgcgggagc tcgacgggtt gccgtccgcg ctggagttcg ccgccgggtg gttcatggtc
    13501 tactcgccgc agcacctgct ggagcggctg cgcaccaacc cgctcgaccc gacctccgca
    13561 cacctgcgcg actcgctgcg gctgtcgctg tccacattgg acgaggagga gcgcgccgcg
    13621 ctgacgcgga tggccggccg gggtgaaggg caggacgacc acgtcacgcg cgcgctgagc
    13681 gtgcgtggac tggttcgccg cgccggacgc cggtacgagg tgctcaacct cgtgcgcgcg
    13741 gcggtgctgg aaccggtgtc agggccacat tccgcggggg gtgtggccct gacctggcct
    13801 tgttagaact gcgccgtgag gcacgcgagg cggtcgccgg cggtgcccgc cttgccgtgc
    13861 tcggtgctgg agtgcgtggc gtggatgatg acggcgttcg cctcgccctt gcggaactcc
    13921 cagttcaccg tggccgtggc ggtcgcggca ccctgcgcgt cggtggtgaa gtcgagccag
    13981 atctcgttct gcgcgttggc gtacttggga tccacgctcg gcgcgaccgg gtccttctcg
    14041 ttctggtagt gcggaccgga gtcggcgggc ttggcgccgc acggcttggt gtgcacgtgc
    14101 gagccgtact tcgtgtccgg ctgcaggccg gacaccttca gctcgaccgt cgtccgtcca
    14161 cccgcgacgg aagagccggt ggagagcttg gcgcccaacg ggatccgctt gacgtcgtag
    14221 gtgatgccct tcggctggtc accggacgcg gccgggccgg cgacctcggt ctcggccacc
    14281 ggcttgacgg cgggagcggc gggggtctcg ccggaacagg cggtcgcacc ggtgagcagg
    14341 gcggcaccca cgagggccgc gacggtcgtg cgcatggttc tccttgtgtc agctgcgttc
    14401 caggttccca cccccaccac gtccaccatc gggtgaccgg ttcagatcaa tcgagacgag
    14461 gtcgcggaac gcgtcttgat aggccgcgca caggtgatag ccgccgtgag tctccacttt
    14521 gtccggagac ccgttcgtct cgctcgcgcg gcggtcgagc gggttggact cccagccgtg
    14581 caccgggaaa ccgaggtagt cggtgcggcg ccacaggttg atccagctcg cgccgaggag
    14641 cgtgctcagc ccgcgatccg gtgtggcacc gggactccgc cgccacgggt cgcgcgagaa
    14701 catcgcgccc gcacgcactt ccggtgtgcc gagcacggcc gggccgagca gctccgggaa
    14761 gatccgcccg aagtacggcc gcagctgcac gccgtaggtc agcagctgcg tgcgttcgag
    14821 gtacccctcc ggcaacgcgt acagcgccgc gaccgccagc acggcgccca ggctgtgcgc
    14881 ggacagcacc acccggttgt ccggcgactc gtccaggaac tcgcgggtcc ggtcggcgat
    14941 ctccggcacc gcgcgttccg cgtagcaggg cggcgcgaac ggatgcgcgg tgcgcggcag
    15001 gaagcacatc aggtcccaca gcaggccgag cggacgccgg ttggtcagca tgccggcgcc
    15061 gacgaacgag ctgatcaccg cgactccggc gagcccggtg acccagtcgc ccttgcccac
    15121 cacccacgtg acgccccacc accccgtcca ggacggcgag gcgaacgtca ggtagcacgt
    15181 gaggatcaac gcgagcacac cgagcgtcga cagcacaccg acgacgttct cggcccggtg
    15241 cgtgacggcg acgacgtgcc gcacccgcac gacgagcacg tcggcctcgt cgtcgagcag
    15301 ggcgggcttg gtcagccgcg acaacaacgc cagcgcctgc gcgatcacca acagcaccag
    15361 cggaaccagt gccaccgcga aggccgcgct gaaccacgag tagaacgacg gaacccgcag
    15421 tcccgtcccc acccagccgc ggaacgtcag caccagcacc gccgccagca tcaccgacgt
    15481 ggtcagcgac aaccccagca gcacaccggg tccggcgccg cgccaggcct gccactcgtc
    15541 gccggaccgc ggccgcgcgc gccacgcgag caccccgccg gccaccacgg cgccgatcca
    15601 ggcgagcggg aaccagtaag tggcaaccat gaacgccacg aacagcacga gcagcgccaa
    15661 cgggcccttg gcgtcgttgc gccgccacga ccatgccgcc agcaccgagc cgagcagcgc
    15721 caccgtgacg accggcggtc cccacgaggc cagccagagc ggcccttcga aaacgggtgc
    15781 gaacccgtag agcccgaacc cgtgcaccac caggacgagc acggccgcga ccaccagcag
    15841 ccacgaccac aggccgccct tctcggtcga cggcacgtcc gggcagtccg tcgctgtcac
    15901 gaccacccgg cccacgacca ccgccagcag accggccgcg aacacggtga gcaccaggaa
    15961 gaacgcgtgc tgtagttgct gggcgctcgt caccagcgtg accacgcaac acccggccgc
    16021 gaggtgcagc cgggtgagcc tgcggatccg cgggctgccc tcccacatcg acgaccggct
    16081 gagcatcacg cccggccgcc gcaccggcgt gcgccgcatc gtcgccatct cgtacctgct
    16141 gcgcgacaac gaggtcagcg ccagcaggcc gaagagcagc aacaccggca cggccgacgc
    16201 ggcgagcacc ctgacgtgcc gcgcgggatc gccgagcagg tccatgaact ccggcagccg
    16261 cttgcaggtg gtgcccggca acgagcactg gatcgcgtac acgtcgatcg cgacctcgca
    16321 caccgcgagc accagcagca ccgtgagccc gagcccgaac agccgcgtgc tggcggcacc
    16381 acgcccggcg ttccaccaca ccatccgcct ggtcgccggc atcgagtcgt cgggaagtct
    16441 gcgggaccag taggcgacgt tcgcgagccc gaacggcagc agcaacgccc atccgatgcg
    16501 ccccaacgcg ttcgcgagca cggacggcac cccgctgccc ggcacgcccg ggctgctgcg
    16561 cgccatgccg ccccacgagt acgcctcgcg acgcacgccg ccgggcaccc gtccggcgtg
    16621 caccggtggc agttcggcga ccttgtccgg cttcggccgc cagaagctgc cgaaccgatc
    16681 tccccggaac tgttcgacgg cgtggtcggg aagggccagc atcgcgtccg ggggcgtgtt
    16741 gttgaccccg tggatgcgca gttcgagggt gcgtggactc atcgccggcc tccctttact
    16801 ccagttgtcg tcctgtcagc tgctccggtt agcggccgaa cgggtgaaaa aggtgtatcc
    16861 aggcgccctg gaaagcctct acttggcaag gaggcgcacc atgaccacaa ccgctcaccc
    16921 gaacgtcgca aactccgtcg gactcgccga gttcctggcc accgcgggca gtctcaccct
    16981 ggcgcagcgc aagctcatcg tcgaccaggc gctgatcctg ctggaacaga actacgcgca
    17041 cctgccgttg aaagtcgcca tgcacgcggt gaaccccgtg caaagactca gggtcctgag
    17101 agccagactc gaacggcaga ccgacgccac ggcggagccc gagtggcagt tccaccgcga
    17161 gctgtcgagc accttccact cggtgcgcga cctgcacacg aactacctcc tgcccgcgcc
    17221 gttcgcgggc aagatcgcct tcctgccgtt ccagctggag cgctgcttcg acgcggacgg
    17281 caccgagcag tacctcgtcg cccgcacggt cgccggtttc gacggtatcg cggtgggcgc
    17341 cgaggtcacg cactggaacg gcacgccgat ctctcgcgcg gtcgcgttga acggcgcgat
    17401 cttcgcgggc agcaacaccg cggcgaacct cgcccgcggc ctggagtcgc tcacgttgcg
    17461 ccccttggtg atccagctcc cgcccgacga ggactgggtc gtcgtgacgt atcgcaacga
    17521 gaacggcgcg tccgaggaca tccgcgtcga ctggcaggtg accgacaacc tgcccccgat
    17581 gaccgacacc gactcgctgt caccggccgc ggccgcgcag ggcgtcgacc tggactccga
    17641 cgagaaggcc cgcgcgaaga agttgttgca cgcccccaag gtcgtgcagg ccgaggccgc
    17701 cggtggtgcc gtcgcgatgt cctcgcagga cgtccccacg accatgcccg gcgtgttccg
    17761 cgcccgcccg gtcaccacgc cgtccggcga gttcggccac ctgcggatct tcaccttcag
    17821 cgtcgacgac ccggacgcgt tcctcaagga gttcgtgcgg ctcgcggctt tgctgccgca
    17881 gaacgggctc atcgtcgacg tgcgcgacaa cggaggcggc cacatcttcg cctcggagtt
    17941 cctgctgcag acgatgacgc cgcggcgcat cgagccggaa ccggtgcagt tcctgagcac
    18001 gccgctgaac ctgcggatct gccgccgcca cgcggacgat ccgaccggcc agatcgacct
    18061 cggcccgtgg ttcccatcgc tggactcgtc gaccgagacc gggcaggcgt tctcctgcgc
    18121 ccacaccatc acgccggtcg ccggcgcgaa cgccgtgggc cagacctacc acggcccggt
    18181 ggtgctgatc accgacgcgc ggtgctactc cgcgaccgac atcttcgccg cgggctgggc
    18241 cgaccacgac ctcggcccga tcctcggcgt ggacgacaac accggtgcgg gcggcgcgaa
    18301 cgtgtggacg cacggactgc tgatgacgct gctgaagatt ccggcgccgg gcgacaccga
    18361 gtcgccgtac aagtccttgc ccaacaaggc gaacatgcgc gtctcgatcc gccgcacgtt
    18421 gcgcgtgggc aagctcgccg gcacgccggt ggaggacctc ggcgtgcggc cgacgcacca
    18481 gcacaaggtg acgcgggcgg atctgttgca gggcaacgtc gatctgctgg cgaaggcggg
    18541 ctcgctgctc gccgcgctgc cggtgcggcg gctgggagtg gcggtcgcgg ggacgaccgt
    18601 ctcgctggac accgtgaacc tcgaccgggt cgacatctac gtcgacggcc gcccggccac
    18661 ctcgctggac gtgaccgacg gcgcgcacac cgcgacgttg agcgcgaccg ggaacgaggt
    18721 gcgggtcgag ggcttcgcgg acgggcagct ggtggccgcg cgcaaggtca ccggttgaaa
    18781 gagcgggcgc tgccggtgac tccacgaccg gcagcgcccg ctcctgttgt gctacttctt
    18841 ggtgaacgtg aaggcgcggt cggtggccag agcccccagc tgtgcctcgg tgccctgcgt
    18901 ccagctctga acccagacca cctcaccgtt cgggcggaag ttgcgggctt ccacgatgcc
    18961 gaaccgctcg tccttgctga agacggtcac gccacccttg tggtcgctca cggtgctggt
    19021 gcacgtggcg tacttctcgc agtactcctt cggcgaccac tcgtgcatgc ccggtgcgtt
    19081 gacctgcgtg tacgtcgtga cgtcctggcc cttgtaggtg aacgtcacgg tgttgcccat
    19141 gtactgcatg ccgtcgaaca cgcctgccgc ctcgccgccc cacgggcccg gctcgacgtt
    19201 ctgcgcgccc cggaaggcgc gcgggtaggt cttctcctgc cgtgcgctga actcgtcggc
    19261 ctgcttctgc agttccgcct tggtcttgtg aacgggcgtg acgtccttcg gcggccacgg
    19321 gtagtccgtg gaggcggacg cggtgcccgc gagaccgagg agtgcagcgc ctgccagggc
    19381 agccgccatt accttgcgca ttgatccccc actagcgagt ttgtgcttgc gcagtaggag
    19441 acgccgcaag atcaccagag gttgcacgcg acttttcgtg ttctcacaac ggtgtttaac
    19501 gtgtgaacgt gtaggcgcgg tcggaggcca ccgctcccag cagggccggg tcgtcctgcc
    19561 gggacccctg ggtgaagacc acttcgccgt tcgggcggaa gttgtgcgcc gacctgtcgt
    19621 cgtaactgtc gtcctcggag aagacgatca cgccaccctg gttgtcgctg accgtgccgg
    19681 tgcacgtggt ctgcgcgcag aactcctcag gcgagtcgct gacgaagccg ggtgcgttga
    19741 cctgtgtgat cacactggcc cacacaccct gctccgcgcc gtgcccgcga gtccggcgag
    19801 tgccaggccc gtcagggcag ccgccattgc cttgcgcatg tggatcccat ctgtgagttc
    19861 tcgcttgcgc ggagagacac gctctcggac ggccggctgg ttgcaccctc gtccggctaa
    19921 agccaacctc gccgcatcgc ctgaacaccc gcctggaacc gggtctgcgc accgcaccgg
    19981 tccatcagct gccgcacccg ccgctgcacg gtccgcggcg cgagcccgag ctgccgcgcg
    20041 atcgactcgt cggtcagccc ggcggcgagc agcccgagca ggttcgggtc cacatcggcc
    20101 gcggcggcgt agatccctcc cggactgaac gggatcccct tgtcccagta cagctcgaac
    20161 gtcgaccgca gcacgtccag cagggccgag ggacggatca gcagcacctt gtcgaccacg
    20221 tcgccgttcg cgaccggcag caccgcggcg tgggtgtcga tcacggcgag cttgaacggc
    20281 agcgtcggcg tgacgcgggc acgttcgccg gccgcgacca gttcgatgat ctcggtgacg
    20341 cggccgggca ggtccaccgc ggaccggtcg tagacgacgc gccacttcac gtcgcgctgg
    20401 cgggtcgcgt cctcgagcgc gacgtgctcg cccagcgggg tcacgtacgg tggctggtcg
    20461 agcacgcaca cctcctcgcg ggcgccgttg agcagcgtgt tccacagttc gcggacggcg
    20521 ccgagcccgc tcacgacctc gacgaacgcg ttgtcggcct gctcctcgtc gcggttgcgc
    20581 aggtagagct ccatcagcgg gccgacgtcg gcgcgggccc tgcggttctg ctcctcacgg
    20641 gccgcgatga gcgcctccac ggcgaggtcg ggcgcgacag cctgccacac gtcgcccggc
    20701 aggtggcgga ccacgccgag ctcgtgcagc cgcgtgagca gctctggggc gacgccgatc
    20761 tcggcggtgg tacggctgcc tcccgttacc agcagctcgt atagggcaga tagctccggc
    20821 gagacgccca gatgtccgaa cacggccaca ttgtgcgcca ttcagcgcaa cacccctgtc
    20881 gtgaacacgt cagtgtcgtt attcggccgt cttaaaaact gtttaaggcg gtccgccgct
    20941 gcttacggtc ctcggcacct ccgcagccgg ttcagaaccc tgacgccctc cacggcatgc
    21001 ggtggccctg tgtggaagga cctctcgtga acggattgcg acgcacgagt ctgtgcgccg
    21061 cggcagtttc cgccgccgtg ctcagcgttg tctcaccagt caacgccgct ccctcccagg
    21121 ttcagtccca gccggactcg acccaggtga accgcccctt cgagcggctg atcgtcggct
    21181 acaagccggg caccgccgaa gcctcgtccg actccgctgc ctcggacgat gtgaagaaca
    21241 agggcaagtc gctgcaccgc cgcatggcga gtggtgcggt cgtcgtcgac ctcggctcga
    21301 agacctcgaa cgccgactcg accatccagg ccttcaaggc cgaccccgat gtcgcctacg
    21361 tcgagccgga cctgctgatg cagccgttcg ccgacccgaa cgacaccgac tactcccggc
    21421 agtgggacct gttcgaggcc accgcgggca tgaacgtgcc cggcgcgtgg tccagcacca
    21481 ccggcgcggg cgtgaccgtc gccgtgatcg acaccggtta cgtcgcgcac agcgacctct
    21541 cggcccgggt cgtcgcgggg tacgacttcg tgtcggacgc cacgcgtgcc cgtgacaaca
    21601 acggtcgtga ctccaaccct gccgacgagg gcgactgggt cgctcgcggc gagtgcggca
    21661 ccgacgccaa cggcaacccg gtgcccgccg ccgaccaggg ctcgtcctgg cacggcacgc
    21721 acgtggccgg caccatcgcc gcgtccacga acaacgccaa gggcatcgcg ggcatcgcct
    21781 acgacgccaa gatccagccg ttgcgcgtgc tcgccaagtg cggtggcgcg acctcggaca
    21841 tcgccgacgc gatcacctgg gcgtccggcg gcacggtgag cggtgtcccc gcgaacgcca
    21901 cgcccgccaa ggtcatcaac atgtcgctgg gcggtcagtc gtcctgctcg acgacctacc
    21961 agaacgcgat caacggcgcg atcaaccgcg gcaccaccgt ggtcgtcgcg gccggcaact
    22021 cgaacatgaa cgtcgccaac ttcaccccgg cgaactgcag cggcgtcatc accgtcgccg
    22081 cgtcgtcccg tgagggcaac aaggcgttct actcgaactt cggcacccgc atcgacatcg
    22141 cggcgcccgg cggggagacc cgtcgcggca ccgacacccc cggcacgatc accacgccgg
    22201 agaacggcat ctggtcgacg ctgaacgccg gcaccaccac ccccggtgcc gagaactaca
    22261 agccgtacca gggcacgtcg atggccgccc cgcacatcgc gggcctcgcg gcactgctgg
    22321 tggcgaagaa gccgtcactc acgcccgccc agatcaagga cctgatcaag acgaacgccc
    22381 gtgccctgcc gggtacgtgc tccggtggct gcggtgccgg cctggccgac gccaccaaga
    22441 ccgtgaacgc cgtcgacacg actccgccgc cctccggtgg cctggagaac acgaccgacg
    22501 tccccatcac ggacatgggc accgtcacgt cctcgatcag ctccacggtg acgggcaacg
    22561 cgtcctccac caccaaggtc ggcgtggaca tcgtc
//
